Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.84206122
Coimmunoprecipitation studies demonstrate that Bcl xL associates with cytochrome C . 0.84206122^^^ Cytochrome C binds directly and specifically to Bcl xL and not to the proapoptotic Bcl xs protein . 0.59751211^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Overexpression of Bcl 10 ( L ) inhibits Ara C induced mitochondrial loss of cytochrome c and other perturbations that activate the molecular cascade of apoptosis . ^^^ These findings indicate that Bcl 10 ( L ) inhibits HIDAC induced preapoptotic mitochondrial perturbations , which prevent the accumulation of cytochrome c in the cytosol , thereby preserving caspase 3 in the inactive zymogen state and checking the molecular cascade of apoptosis . . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Release of cytochrome c and decrease of cytochrome c oxidase in Bax expressing yeast cells , and prevention of these effects by coexpression of Bcl xL . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Bcl xL has activity independent of cytochrome c release . ^^^ In the present report , we use microinjection techniques to investigate the relationship between cytochrome c release , induction of apoptosis , and Bcl xL activity in intact cells . ^^^ Although MCF7F cells are insensitive to cytochrome c microinjection , they rapidly undergo apoptosis in a caspase dependent manner in response to either tumor necrosis factor or anti Fas plus cycloheximide , and these deaths are strongly inhibited by Bcl xL expression . ^^^ Furthermore , microinjection of cytochrome c does not overcome these antiapoptotic effects of Bcl xL . ^^^ Importantly , the ability of Bcl xL to inhibit cell death in the cytochrome c insensitive MCF7F cells can not be due solely to inhibition of cytochrome c release from mitochondria . . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Human IAP like protein regulates programmed cell death downstream of Bcl xL and cytochrome c . ^^^ Redistribution of cytochrome c from mitochondria , an early event in apoptosis , was not blocked by overexpression of hILP but was inhibited by Bcl xL . ^^^ In contrast , hILP , but not Bcl xL , inhibited apoptosis induced by microinjection of cytochrome c . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
The apoptosis inhibitors Bcl 2 or Bcl xL prevent the efflux of cytochrome c from mitochondria . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
In addition , Bcl xL prevented the change in cytochrome c immunolocalization induced by anti Fas or TNF alpha treatment . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
The results further demonstrate that multidrug resistant cells exhibit a block in the release of mitochondrial cytochrome c into the cytosol and that this effect is dependent on overexpression of Bcl xL . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
In contrast , Taxol treatment ( 500 nM for 24 h ) triggered the molecular cascade of apoptosis , represented by the cytosolic increase of cytochrome c and poly ( ADP ribose ) polymerase or the DNA fragmentation factor cleavage activity of caspase 3 in HL 60 / neo cells as well as in HL 60 / Bcl xLdelta and HL 60 / Bcl 2delta cells , but not in their counterparts overexpressing full length Bcl 2 and Bcl xL . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
DP cells before IL 3 depletion led to increased levels of Bcl XL , prevented reduction of Psim and the release of mitochondrial cytochrome c , and suppressed apoptosis . ^^^ DP cells ; that 5 Abl TK activation , probably via upregulation of Bcl XL , prevents loss of Psim and blocks the release of cytochrome c from mitochondria ; and that neither of these mitochondrial events is sufficient for commitment to apoptosis . . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Caspase cleaved BID targets mitochondria and is required for cytochrome c release , while BCL XL prevents this release but not tumor necrosis factor R1 / Fas death . `` BH 3 domain only ' ' members of the BCL 2 family including the pro apoptotic molecule BID represent candidates to connect with proximal signal transduction . ^^^ However , BCL XL / BCL 2 prevented the release of cytochrome c , yet other aspects of mitochondrial dysfunction still transpired and cells died nonetheless . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Overexpression of Bcl 2 and Bcl XL suppressed caspase activation , mitochondrial cytochrome c release , Deltapsi suppression , and apoptosis and cell death induced by GraB , GraK , or perforin . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Bax induced caspase activation and apoptosis via cytochrome c release from mitochondria is inhibitable by Bcl xL . ^^^ In contrast , Bcl xL was capable of preventing cytochrome c release while also significantly inhibiting cell death . ^^^ It would therefore appear that the mitochondrial release of factors such as cytochrome c represents a critical step in committing a cell to death , and this release is independent of permeability transition and caspase activation but is inhibited by Bcl xL . . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Nonetheless , there were no significant alterations in levels of immunoreactive Bcl 2 , Bcl 10 ( L ) , Bax , Bad , and Bak , nor any evidence of cytochrome c release into cytosol and dissipation of delta ( psi ) m . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
We find that ( 1 ) Bax ( delta ) is as efficient as full length Bax in promoting cytochrome c release , but Bcl 10 ( L ) delta has remarkably reduced rescuing ability compared to full length Bcl 10 ( L ) ; ( 2 ) full length Bcl 10 ( L ) protein acts by relocalizing Bax from the mitochondrial fraction to the soluble cytosolic fraction ; ( 3 ) Bax undergoes N terminal cleavage when expressed in yeast , which is prevented by coexpression of Bcl 10 ( L ) , suggesting that Bcl 10 ( L ) may mask the cleavage site of Bax through a direct physical interaction of the two proteins . . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
The anti apoptotic members of this family , such as Bcl 2 and Bcl XL , prevent apoptosis either by sequestering proforms of death driving cysteine proteases called caspases ( a complex called the apoptosome ) or by preventing the release of mitochondrial apoptogenic factors such as cytochrome c and AIF ( apoptosis inducing factor ) into the cytoplasm . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
METHODS : Primary bovine glomerular endothelial cells were stimulated with TNF alpha or LPS , and apoptotic cell death was investigated by DNA fragmentation analysis , morphological studies , measurement of cytochrome c efflux and mitochondrial permeability transition , Bak , Bad , Bax , Bcl 2 , Bcl xL protein expression , and caspase 3 like protease activity . ^^^ Mechanistically , TNF alpha induced cell death was preceded by an efflux of mitochondrial cytochrome c into the cytosol and , subsequently , by a marked increase in the proapoptotic protein Bak and a decrease in the anti apoptotic Bcl xL protein content . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
The cytochrome c releasing activity was not blocked by caspase inhibition , but was antagonized by Bcl 2 or Bcl xL . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Bax and Bak allow cytochrome c to pass through VDAC out of liposomes , but passage is prevented by Bcl 10 ( L ) . ^^^ In agreement with this , VDAC 1 deficient mitochondria from a mutant yeast did not exhibit a Bax / Bak induced loss in membrane potential and cytochrome c release , both of which were inhibited by Bcl 10 ( L ) . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Exposure of undifferentiated U 937 cells to 50 microM etoposide for 6 h , that triggers apoptosis in 80 % cells , activates procaspase 2L , 3 and 8 , induces the mitochondrial release of cytochrome c and decreases Mcl 1 expression without modifying Bcl 2 , Bcl xL and Bax protein levels . ^^^ Exposure of TPA differentiated U 937 cells to 0 . 8 microg / ml cycloheximide for 24 h , that triggers apoptosis in 50 % cells , activates procaspase 2L , 3 and 8 , induces the mitochondrial release of cytochrome c and decreases Bcl xL expression without modifying Bcl 2 , Mcl 1 and Bax protein levels . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
The expression of the mitochondrial factors Bcl 2 , Bcl 10 , and Bax was determined because each has been implicated in the regulation or release of cytochrome c at the level of the mitochondria . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Overexpression of Bcl 2 or Bcl 10 ( L ) inhibited TG induced loss in mitochondrial membrane potential , release of cytochrome c , and activation of caspase 3 and JNK . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
The anti apoptotic members Bcl 2 and Bcl xL may also control caspase activation independently of cytochrome c relocalisation or may inhibit a positive feedback mechanism [ 4 ] [ 5 ] [ 6 ] [ 7 ] . ^^^ We found that Bcl 2 and Bcl xL set a threshold in the amount of cytochrome c required to activate caspases , even in soluble extracts lacking mitochondria . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Loop ' domain deletional mutant of Bcl xL is as effective as p29Bcl xL in inhibiting radiation induced cytosolic accumulation of cytochrome c ( cyt c ) , caspase 3 activity , and apoptosis . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Bak BH 3 peptides antagonize Bcl xL function and induce apoptosis through cytochrome c independent activation of caspases . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Western blots detected accumulation of the tumor suppressor protein p 53 , relocation of cytochrome c , and expression of the antiapoptotic protein Bcl 10 ( L ) . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Then we determined whether Bcl 2 , Bax , Bcl xL and Bcl xS , which regulate the release of cytochrome c from mitochondria , were altered in the ischemia tolerant CA 1 region . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Similarly , decreased Bax expression during STS treatment , coupled with overexpression of the antiapoptotic Bcl 10 ( L ) and inability to translocate cytochrome c to the cytosol , provided a mechanism for the insensitivity of PC 3 cells . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
In conclusion , dexamethasone inhibits the induction of apoptosis in astrocytoma cells , probably via an up regulation of Bcl 10 ( L ) , which could prevent cytochrome c release from mitochondria and subsequent caspase activation . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Here we investigated the biochemical role of the conserved N terminal homology domain ( BH 4 ) of Bcl 10 ( L ) , which has been shown to be essential for inhibition of apoptosis , with respect to the regulation of mitochondrial membrane permeability and found that BH 4 was required for Bcl 10 ( L ) to prevent cytochrome c release and Deltapsi loss . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Early release of mitochondrial cytochrome c and expression of mitochondrial epitope 7A6 with a porphyrin derived photosensitizer : Bcl 2 and Bcl xL overexpression do not prevent early mitochondrial events but still depress caspase activity . ^^^ Enforced overexpression of Bcl 2 or Bcl xL prevented cytochrome c release and 7A6 expression produced by ultraviolet B light treatment , but did not prevent cytochrome c release or 7A6 expression elicited by verteporfin photosensitization . ^^^ This observation indicates that cells overexpressing Bcl 2 or Bcl xL exhibit resistance to caspase activation even after the appearance of cytochrome c in the cytosol . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Overexpression of the anti apoptotic proteins Bcl 2 or Bcl XL that blocked loss of the mitochondrial membrane potential and cytochrome c release from mitochondria conferred resistance to BetA at the level of mitochondrial dysfunction , protease activation and nuclear fragmentation . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Considering the function of PBR in cholesterol uptake and intramitochondrial movement , we propose that decreased PBR expression may lead to reduced levels of mitochondrial membrane cholesterol , which , together with the ability of Bcl 10 ( L ) and Bax to form ion channels , produces breaks in the outer membranes allowing the exit of cytochrome c , thus triggering apoptosis . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Overexpression of Bcl xL blocked various aspects of paclitaxel mediated apoptosis , including caspase 3 activation , degradation of poly ( ADP ribose ) polymerase ( PARP ) , loss of mitochondrial membrane potential ( Delta Psim ) , and release of cytochrome c . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Apoptosis , activation of caspases , and cytochrome c release were blocked by Bcl 10 ( L ) overexpression in Jurkat T cells , suggesting a critical role for mitochondria in ELL 12 triggered cell death . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
The earliest event induced by drug exposure was increase in Bad protein levels , followed by Bcl 2 down regulation , cytochrome c release , and Bcl xL and Bax up regulation . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Overexpression of Bcl 10 ( L ) blocked cytochrome c release , caspase 3 activation , and apoptosis in ara C treated cells . ^^^ By contrast , CDDO induced release of cytochrome c , and activation of caspase 3 were diminished only in part by Bcl 10 ( L ) . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Bcl 10 ( L ) cooperates with Z VAD fmk by blocking the Type 2 pathway at the level of cytochrome c release . ^^^ Surprisingly , although Bcl 10 ( L ) was able to block cytochrome c release , it was unable to block mitochondrial depolarization , suggesting that these are separate events . ^^^ Bcl xL inhibits cytochrome c release but not mitochondrial depolarization during the activation of multiple death pathways by tumor necrosis factor alpha . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
These results indicate that Bax promotes apoptosis regardless of ceramide formation and that Bcl 2 or Bcl xL prevents ceramide formation by repressing neutral sphingomyelinase as well as ceramide induced cytochrome c release . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
We have recently shown that some of these proteins , such as Bcl 10 ( L ) , Bax , and Bak , directly modulate the mitochondrial voltage dependent anion channel ( VDAC ) and thus regulate apoptogenic cytochrome c release and potential loss . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Caspases are known to cleave Bid , a proapoptotic family member , as well as Bcl 2 and Bcl 10 ( L ) , two prosurvival family members , which activate their cytotoxic activity resulting in the release of cytochrome c from mitochondria . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Previous reports have suggested at least two distinct mechanisms : Bcl 2 and Bcl xL may inhibit either the formation of the cytochrome c / Apaf 1 / caspase 9 apoptosome complex ( by preventing cytochrome c release from mitochondria ) or the function of this apoptosome ( through a direct interaction of Bcl 2 or Bcl xL with Apaf 1 ) . ^^^ At low concentrations ( 50 nM ) , Bcl xL was able to block the release of cytochrome c from mitochondria . ^^^ However , although Bcl xL did associate with Apaf 1 , it was unable to inhibit caspase activation induced by the addition of cytochrome c , even at much higher concentrations ( 1 5 microM ) . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Tumour necrosis factor alpha ( TNF alpha ) and lipopolysaccharide ( LPS ) induced apoptosis of bovine glomerular endothelial cells is now recognized as an important part in the pathogenesis of glomerulonephritis characterized by early mitochondrial cytochrome c release , mitochondrial permeability transition , Bak protein upregulation , Bcl 10 ( L ) protein downregulation and caspase 3 activation . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
After the death stimuli , Bcl 2 and Bcl 10 ( L ) precluded the release of the Apaf 1 cofactor cytochrome c from mitochondria and the formation of larger Apaf 1 complexes , which are steps that presage apoptosis . ^^^ However , neither Bcl 2 nor Bcl 10 ( L ) could prevent the in vitro activation of Apaf 1 induced by the addition of exogenous cytochrome c . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
We have previously shown that Bax and Bak open the voltage dependent anion channel ( VDAC ) allowing cytochrome c to pass through the channel , and Bcl xL closes the channel . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Amelioration of the leakage of cytochrome c and apoptosis requires not only the increase of Bcl 10 ( l ) / Bax ratio , but also the release of Bcl 10 ( l ) from Bax at the membrane . . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
We also found that hGsn and its C terminal half but not mGsn could prevent apoptotic mitochondrial changes such as Apsi loss and cytochrome c release in isolated mitochondria to a similar extent as Bcl xL , indicating that hGsn targets the mitochondria to prevent apoptosis via its C terminal half . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
The release of cytochrome c can be influenced by different Bcl 2 family member proteins , including , but not limited to , Bax , Bid , Bcl 2 , and Bcl 10 ( L ) . ^^^ Bax and Bid potentiate cytochrome c release , whereas Bcl 2 and Bcl 10 ( L ) antagonize this event . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
The dependence on Bid , and thus on the mitochondrial cytochrome c release , of hepatocyte apoptosis induced by the death receptors also renders it sensitive to the inhibitory regulation by the anti apoptosis members of the Bcl 2 family proteins , such as Bcl 2 and Bcl xL . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
A detailed study on bcl 2 superfamily gene expression shows that TGF beta produces a decrease in the messenger RNA ( mRNA ) and protein levels of bcl 10 ( L ) , an antiapoptotic member of this family , capable of preventing cytochrome c release . ^^^ We conclude that PI 3 kinase mediates the survival effect of EGF on TGF beta induced death by acting upstream from the mitochondrial changes , i . e . , preventing bcl 10 ( L ) down regulation , cytochrome c release , and activation of caspase 3 . . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Caspase 9 is autoprocessed by the Apaf 1 / cytochrome c pathway and acts at an early point in this cascade , whereas Bcl xL , an antiapoptotic member of the Bcl 2 family , prevents activation of caspases in vitro . ^^^ Furthermore , we demonstrate that Bcl xL blocks cytochrome c release from mitochondria , causing activation of caspase 9 in anterior horn cells and dorsal root ganglia neurons in mouse embryos at embryonic day 11 . 5 . . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Importantly , the early release of cytochrome c from mitochondria closely correlates with the degradation of Bcl 2 and Bcl xL and a decrease in the ratios of Bcl 2 and Bcl xL to Bax during STA . ^^^ These findings suggest that the degradation of Bcl 2 and Bcl xL may favor Bax to induce cytochrome c release from mitochondria , which subsequently activates downstream caspases in STA . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
C5a blockade in the sepsis model almost completely inhibited caspase 3 , 6 , and 9 activation , significantly preserved cytochrome c in the mitochondrial fraction , and restored Bcl 10 ( L ) expression . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
These data indicate that AMD induces cytochrome c release from mitochondria , triggering apoptosis through an iodine independent mechanism , and that this process is not mediated by modulation of p 53 , Bcl 2 , Bcl XL , or Bax protein expression and does not involve the generation of free radicals . . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Overexpression of the anti apoptotic proteins Bcl 2 or Bcl 10 ( L ) that blocked loss of the mitochondrial membrane potential and cytochrome c release from mitochondria also conferred resistance to BetA . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Western blots detected accumulation of the tumor suppressor protein p 53 , relocation of cytochrome c to the cytosol , and expression of the anti apoptotic protein Bcl xL . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Second , we show that commitment and postmitochondrial execution of BCR mediated apoptosis are not dependent on caspase activation by demonstrating that such apoptotic signaling does not induce release of cytochrome c from the mitochondria or activation of effector caspases , as evidenced by poly ( ADP ribose ) polymerase or Bcl 10 ( L ) cleavage . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
However , stable expression of Bcl 2 and Bcl xL did suppress these apoptotic events , including the release of cytochrome c from mitochondria , which was observed in drug treated H 460 cells . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Unlike Bcl 10 ( L ) , DeltaN61Bcl 10 ( L ) and DeltaN76Bcl 10 ( L ) caused the release of cytochrome c from mitochondria in vivo and in vitro . ^^^ Furthermore , only DeltaN61Bcl 10 ( L ) and DeltaN76Bcl 10 ( L ) , but not Bcl 10 ( L ) , formed pores large enough to release cytochrome c and to destabilize planar lipid bilayer membranes through reduction of pore line tension . ^^^ Pro apoptotic cleavage products of Bcl xL form cytochrome c conducting pores in pure lipid membranes . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Traveling mitochondrial waves are prevented by Bcl 10 ( L ) , involve permeability transition pore ( PTP ) opening , and yield cytochrome c release , caspase activation and nuclear apoptosis . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
In this study , we demonstrate that IFN gamma induces apoptosis in WEHI 279 mouse B cells and IL 7 dependent mouse pre B cells by disrupting mitochondrial membrane potential and cytochrome c release via down regulation of Bcl 2 and Bcl 10 ( L ) . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Moreover , expression of Bcl 10 ( L ) mutated at sites of SAPK phosphorylation ( Thr 47 , 115 ) was more effective than wild type Bcl 10 ( L ) in abrogating TPA induced cytochrome c release and apoptosis . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Neural precursor cell apoptosis was also unaffected by targeted disruptions of Bclx and Bcl 2 , and unlike neurotrophic factor deprivation induced neuronal apoptosis , was not associated with a detectable loss of cytochrome c from mitochondria . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
These data provide evidence that the apoptosis induced by VCD in ovarian small preantral follicles of rats is associated with increased expression of Bad protein , redistribution of Bcl 10 ( L ) protein and cytochrome c from the mitochondria to the cytosolic compartment , and an increase in the Bax / Bcl 10 ( L ) ratio in the mitochondria . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
However , events downstream of mitochondria , such as release of cytochrome c , only occur in the vector transfected MCF 7 Fas cells , and no in vivo caspase 8 activity can be detected in the Bcl 10 ( L ) expressing cells . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Furthermore , cytochrome c remained localized to the mitochondrial fraction of Ltx treated JY / bcl 2 and JY / bcl xL cells , whereas its presence in the cytoplasmic fraction of JY / gen cells suggests an uncoupling of electron transport . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Bcl 10 ( L ) prevented oxygen deprivation induced cell death by inhibiting the release of cytochrome c and caspase 9 activation . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Bcl 10 ( L ) prevented tBid induced cytochrome c release and depolarization . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Over expression of the anti apoptotic Bcl xL protein had no effect on Dlk / ZIP kinase induced membrane blebbing , but potently inhibited Dlk / ZIP kinase induced cytochrome c release and transition of cells to late stage apoptosis . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Curcumin ( diferuloylmethane ) induces apoptosis through activation of caspase 8 , BID cleavage and cytochrome c release : its suppression by ectopic expression of Bcl 2 and Bcl xl . ^^^ Curcumin treatment also induced BID cleavage and mitochondrial cytochrome c release in neo cells but not in Bcl 2 and Bcl xl transfected cells . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
It also is demonstrated that WISP 1 can prevent cells from undergoing apoptosis following DNA damage through inhibition of the mitochondrial release of cytochrome c and up regulation of antiapoptotic Bcl 10 ( L ) . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Activation of caspases occurs downstream from radical oxygen species production , Bcl xL down regulation , and early cytochrome C release in apoptosis induced by transforming growth factor beta in rat fetal hepatocytes . ^^^ TGF beta 1 mediates radical oxygen species ( ROS ) production that precedes bcl xL down regulation , loss of mitochondrial transmembrane potential , release of cytochrome c , and activation of caspase 3 ( Herrera et al . , FASEB J 2001 ; 15 : 741 751 ) . ^^^ Our results show that TGF beta 1 activates at least caspase 3 , 8 , and 9 in rat fetal hepatocytes , which are not required for ROS production , glutathione depletion , bcl xL down regulation , and initial cytochrome c release . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Moreover , Bid cleavage precedes the initial cytochrome c release , whereas the late , amplified cytochrome c release coincides with changes in levels of Bcl 2 , Bcl 10 ( L ) , and reduction of mitochondrial membrane potential . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Partial inhibition of cytochrome c release by Bcl 10 ( L ) significantly reduced chelerythrine induced apoptosis . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
In a immunohistochemical study , stainings for 8 hydroxy deoxyguanosine ( 8 OH dG ) , 4 hydroxy nonenal ( 4 HNE ) , Mn SOD , Bcl 2 , cytochrome c , DNase 1 and Bcl 10 L showed a pronounced granular distribution in the cytochrome c oxidase ( COX ) negative ragged red fibers ( RRFs ) . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
The markers selected include several biochemical parameters ( downregulation of the antiapoptotic bclX ( L ) gene , caspase 3 activation , and cytochrome C release from mitochondria ) , and flow cytometry determinations ( analysis of the size of the nuclei , chromatin complexity , and DNA integrity ) . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Bcl 2 overexpression was associated with inhibition of caspase 3 activation after reperfusion and increased baseline levels of cytoplasmic cytochrome c , caspase 3 , and a reduction of Bcl 10 ( L ) production . ^^^ Extensive overproduction of Bcl 2 is associated with a compensatory increase of baseline levels of cytoplasmic cytochrome c and caspase 3 , and a deletion of Bcl 10 ( L ) . . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
The involvement of the mitochondria pathway was studied by monitoring cytochrome c release and using H 460 cells stable in overexpressing Bcl 2 or Bcl 10 ( L ) . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Bcl 10 ( L ) protected cells from nitric oxide induced apoptosis during hypoxia by preventing the release of cytochrome c , caspase 9 activation , and by maintaining a mitochondrial membrane potential . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
It inhibits hypoxia induced caspase 3 activation , mitochondrial cytochrome c release , downregulation of Bcl 2 and Bcl 10 ( L ) , upregulation of hypoxia inducible factor ( HIF ) 1 alpha , and loss of mitochondrial transmembrane potential in human leukemia HL 60 cell line . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Rat1a cells exposed to hyperoxia underwent apoptosis characterized by the release of cytochrome c , activation of caspase 9 , and nuclear fragmentation that was prevented by the overexpression of Bcl 10 ( L . ) Murine embryonic fibroblasts from bax ( / ) bak ( / ) mice were resistant to hyperoxia induced cell death . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
The antiapoptotic protein Bcl 10 ( L ) prevented the anoxia induced cell death by inhibiting the release of cytochrome c and caspase 9 activation . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Bcl 10 ( L ) transfected cells showed a remarkable resistance staurosporine induced cytochrome c release and associated apoptotic changes and survived for up to 15 days in 1 microm staurosporine . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Importantly , Bcl 2 and Bcl 10 ( L ) inhibited the release of both cytochrome c and Smac from mitochondria . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Both Bcl 10 ( L ) and calyculin A prevented Bax translocation and cytochrome c release . ^^^ Bcl 10 ( L ) is generally thought to heterodimerize with Bax to prevent cytochrome c release and yet they remain in different cellular compartments , suggesting that their heterodimerization at the mitochondria is not the primary mechanism of Bcl 10 ( L ) mediated protection . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Since no consistent differences in Bcl 2 , Bcl 10 ( L ) or Bax expression were seen in the STS and radiation resistant neuroblastomas , it suggests that a unique mitochondrial signaling factor ( s ) is responsible for the defect in cytochrome c release in this sub group of tumors . . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Bryostatin 1 increases 1 beta D arabinofuranosylcytosine induced cytochrome c release and apoptosis in human leukemia cells ectopically expressing Bcl 10 ( L ) . ^^^ Coadministration of bryostatin 1 with ara C resulted in enhanced cytosolic release of cytochrome c and Smac / DIABLO , procaspase 3 and 9 activation , loss of mitochondrial membrane potential ( Deltapsi ( m ) ) , poly ( ADP ribosyl ) phosphorylase degradation , apoptosis , and loss of clonogenic survival in U937 / Bcl 10 ( L ) cells , although effects were not as marked as in empty vector control cells . ^^^ In contrast , ectopic expression of Bcl 10 ( L ) blocked cytochrome c redistribution as well as all other events involved in ara C / bryostatin 1 mediated apoptosis . ^^^ Finally , the F ( 0 ) F ( 1 ) ATPase inhibitor oligomycin effectively blocked cytochrome c release as well as loss of Deltapsi ( m ) and apoptosis in U937 / Bcl 10 ( L ) cells . ^^^ Together , these findings support the concept that bryostatin 1 potentiates ara C lethality in human leukemia cells ectopically expressing Bcl 10 ( L ) by diminishing the capacity of this antiapoptotic protein to antagonize cytochrome c release . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Radioresistant clonal lines 1F2 , 2C6 and 32D Bcl xl showed significant decreases in mitochondrial membrane permeability , cytochrome C release , caspase 3 and poly ( adenosine diphosphate ribose ) polymerase ( PARP ) activation at 6 12 h , and in apoptosis at 24 h . ^^^ Since the nuclear to cytoplasm events preceding the release of cytochrome C were similar in all cell lines , and increased expression of either the SOD 2 or the BCL2L1 transgene provided radiation protection , we conclude that events at the level of the mitochondria are critically involved in radiation induced apoptosis . . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NF kappaB mediated up regulation of Bcl 10 ( S ) and Bax contributes to cytochrome c release in cyanide induced apoptosis . ^^^ Up regulation of pro apoptotic Bcl 10 ( S ) and Bax contributed to cyanide induced cytochrome c release , because SN 50 and a specific Bax antisense oligodeoxynucleotide significantly reduced release of cytochrome c from mitochondria as shown by western blot analysis . ^^^ It was concluded that NF kappaB mediated up regulation of Bcl 10 ( S ) and Bax is involved in regulating cytochrome c release in cyanide induced apoptosis . . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Intracisternal administration of aluminum into rabbit brain induces cytochrome c release , decreases levels of the anti apoptotic proteins Bcl 2 and Bcl 10 ( L ) , increases levels of the pro apoptotic Bax , activates caspase 3 , and causes DNA fragmentation as measured by the TUNEL assay . ^^^ Pretreatment for 14 days with 7 mm of lithium carbonate in drinking water prevents aluminum induced translocation of cytochrome c , and up regulates Bcl 2 and Bcl 10 ( L , ) down regulates Bax , abolishes caspase 3 activity and reduces DNA damage . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
These results demonstrate that the cytotoxic effect of L canavanine on Jurkat T cells is attributable to the induced apoptosis and that L canavanine induced apoptosis is mediated by a cytochrome c independent caspase 3 activation pathway that can be interrupted by Bcl 2 or Bcl xL . . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Mitochondrial markers cytochrome c and Bcl 10 ( L ) are upregulated in both Plp mutants but levels of expression are different between mutants , suggesting that apoptosis in these two Plp mutants follows different pathways . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
DEX increases the expression of anti apoptotic Bcl 2 and Bcl 10 ( L ) proteins , decreases the expression of pro apoptotic Bax and inhibits Bad translocation thereby preventing the release of cytochrome c , the activation of caspases , and cell death . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Bcl XL protects BimEL induced Bax conformational change and cytochrome C release independent of interacting with Bax or BimEL . ^^^ Moreover , the Bcl XL mutant ( mt 1 ) , which is unable to interact with Bax and BimEL , blocks Bax conformational change and cytochrome c release induced by BimEL in intact cells and isolated mitochondria . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
CD 40 ligation and TNF alpha prevented release of cytochrome c and activation of caspase 3 , which could not be explained by effects on the expression of Bcl 2 , Bcl 10 ( L ) or Bax . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Peptides derived from BH 3 domains of Bcl 2 family members : a comparative analysis of inhibition of Bcl 2 , Bcl 10 ( L ) and Bax oligomerization , induction of cytochrome c release , and activation of cell death . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
The apoptosis triggered by H 6 was accompanied by up regulation of Bcl 10 ( S ) , accumulation of cytosolic cytochrome c and activation of caspase cascade ( caspase 9 and 3 ) . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
This might be related to decreased Bcl xL expression and increased bax expression , which is subsequently followed by cytochrome c release and caspase activation and also by microglia mediated inflammatory responses via the NFkappaB and mitogen activated protein kinase pathways . . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Pyruvate significantly increased the ratio of Bcl Xl ( antiapoptotic molecule ) / Bax ( proapoptotic molecule ) , prevented the release of cytochrome c from mitochondria , and decreased the fragmentation of caspase 3 and poly ( ADP ribose ) polymerase ( DNA repair enzyme ) . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Treatment with tea polyphenols or the major tea component epigallocatechin 3 gallate blocked expression of the hyper , but not hypophosphorylated Bcl 10 ( L ) in mitochondria , accompanied by cytochrome c release , caspase activation , and apoptosis . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
BCR ligation activated mitochondrial apoptotic pathways including down regulation of Bcl 10 ( L ) , dissipation of mitochondrial transmembrane potential , release of cytochrome c , and activation of caspase 9 . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
In both cell types , apoptosis correlated with decreased levels of bcl 10 ( L ) , release of cytochrome c from the mitochondria and activation of caspase 3 . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
In contrast , cytochrome c release from the mitochondria involves dynamic changes in Bcl 2 family proteins ( e . g . up regulation of Bak , Bcl 2 , and Bcl 10 ( L ) ) , opening of permeability transition pore , and loss of mitochondrial membrane potential . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
The release of cytochrome c is the central gate in turning on / off apoptosis , and is regulated by the interaction of proapoptotic proteins , including Bid , Bax and Bak , and antiapoptotic proteins including Bcl 2 and Bcl 10 ( L ) , and a specific class of inhibitors of apoptosis proteins ( IAPs ) including Akt , survivin , and heat shock proteins . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Moreover , by modification of anti apoptotic members of the Bcl 2 family ( e . g . upregulation of Bcl 10 ( L ) ) BCR / ABL provides a cytoplasmic ' umbrella ' protecting mitochondria from the ' rain ' of apoptotic signals coming from the damaged DNA in the nucleus , thus preventing release of cytochrome c and activation of caspases . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
The release of cytochrome c can be influenced by different Bcl 2 family member proteins , including Bax , Bid , Bcl 2 , and Bcl 10 ( L ) . ^^^ Bax and Bid potentiate cytochrome c release , whereas Bcl 2 and Bcl 10 ( L ) antagonize this event . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
We detected a decrease in the expression of bcl 2 and bcl 10 ( L ) , two antiapoptotic proteins that decrease mitochondrial membrane permeability , an increase in cytochrome c immunoreactivity in the cytosolic fraction , and an activation of caspase 9 in brain regions which show apoptotic neurodegeneration following percussion brain trauma in 7 day old rats . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Whereas IL 4 and PPARgamma ligands failed to induce cleavage of Bid and release of cytochrome c from mitochondria , they caused translocation of the proapoptotic protein Bax from cytoplasm to mitochondria with a concomitant decrease in the Bcl 10 ( L ) level . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Over expression of Bcl xl inhibits apoptotic changes induced by Etoposide including cytochrome c release , caspase 3 activation and DNA fragmentation . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Expression of Bcl 10 ( S ) in Xenopus oocytes induces BH 3 dependent and caspase dependent cytochrome c release and apoptosis . ^^^ The results showed that expression of Bcl 10 ( S ) in oocytes induces oocyte death by a caspase dependent mechanism , which includes BH 3 dependent cytochrome c release and is inhibited by co expression of the anti apoptotic proteins Bcl 2 and Bcl 10 ( L ) . ^^^ These findings suggest that Bcl 10 ( S ) induces apoptosis in Xenopus oocytes mainly by its presence in the mitochondria , where it induces BH 3 and caspase dependent release of cytochrome c , which leads to oocyte death . . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Apoptosis involved the mitochondrial pathway with decreased levels of Bcl 2 and Bcl 10 ( L ) protein , release of cytochrome c , and increased caspase 3 activity . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Mouse uterine epithelial apoptosis is associated with expression of mitochondrial voltage dependent anion channels , release of cytochrome C from mitochondria , and the ratio of Bax to Bcl 2 or Bcl 10 . ^^^ In addition , the apoptotic index showed good correlation with the release of cytochrome c from mitochondria , activation of caspase 3 , which was immunohistochemically detected only in the epithelium , and the mRNA and protein ratios of Bax : Bcl 2 and Bax : Bcl 10 in the uterus . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
The molecular mechanisms underlying the initiation and control of the release of cytochrome c during mitochondrion dependent apoptosis are thought to involve the phosphorylation of mitochondrial Bcl 2 and Bcl 10 ( L ) . ^^^ Although the c Jun N terminal kinase ( JNK ) has been proposed to mediate the phosphorylation of Bcl 2 / Bcl 10 ( L ) the mechanisms linking the modification of these proteins and the release of cytochrome c remain to be elucidated . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
When Bcl XL was overexpressed normal state 3 respiration and mitochondrial morphology were maintained and cytochrome c release was inhibited in the face of glucose deprivation stress . . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Apaf 1 , Bcl xL , cytochrome c , and caspase 9 form the critical elements for cerebral vascular protection by erythropoietin . ^^^ Endothelial cell injury was evaluated by trypan blue , DNA fragmentation , membrane phosphatidylserine exposure , apoptotic protease activating factor 1 ( Apaf 1 ) , and Bcl XL expression , mitochondrial membrane potential , cytochrome c release , and cysteine protease activity . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
In contrast , when cytochrome c release from mitochondria is inhibited by overexpression of the anti apoptotic proteins B cell lymphoma / leukemia ( Bcl ) 2 or Bcl 10 ( L ) , nitrosylated cytochrome c is found in the mitochondria . ^^^ These data suggest that during apoptosis , cytochrome c is nitrosylated in mitochondria and then rapidly released into the cytoplasm in the absence of Bcl 2 or Bcl 10 ( L ) overexpression . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
The improved methodology could generate a large quantity of rhVDAC 1 with correct folding in terms of the secondary structure , with full biological activities in mediating cytochrome c release and in interaction with Bcl 10 ( L ) . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
OBJECTIVE : To investigate the effects of anti apoptosis gene ( bcl 10 ( L ) ) , cytochrome c and caspase 3 activity on chemoresistance in cisplatin resistant human ovarian cancer cell lines ( A2780 / DDP , COC1 / DDP ) . ^^^ METHODS : The expression of bcl 10 ( L ) cisplatin treated cytochrome c and caspase 3 activity were monitored by RT PCR and Western blot in cisplatin resistant ( A2780 / DDP , COC1 / DDP ) and cisplatin sensitive ( A 2780 , COC 1 ) cell lines . ^^^ RESULTS : The expression of bcl 10 ( L ) in A2780 / DDP and COC1 / DDP was significantly higher than that in A 2780 and COC 1 cells , whereas the expression of cytochrome c , caspase 3 activity and apoptotic rates of A2780 / DDP and COC1 / DDP were significantly reduced more than those of A 2780 and COC 1 after having been treated by cisplatin ( P < 0 . 05 ) . ^^^ CONCLUSION : The overexpression of anti apoptotic gene bcl 10 ( L ) , which downregulates cytochrome c and decreases caspase 3 activity , may be related to cisplatin resistance in human ovarian cancer cell lines . . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Moreover , the expression of cytochrome C , caspases 3 and 8 and PARP genes was increased after treatment and the gradual reduction of Bcl XL protein was observed , which indicate that the apoptotic signals were induced after treatment by troglitazone . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Curcumin induces apoptosis in U 937 cells via a mechanism that appears to involve down regulation of the anti apoptotic Bcl xL , and IAP proteins , release of cytochrome c , and activation of caspase 3 . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Bcl 10 ( L ) expression prevents the release of mitochondrial Cytochrome c and apoptosis , but not Bax translocation . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
The cell death was not suppressed by exogenous His PTD Bcl 10 ( L ) at all , suggesting involvement of a Bcl 10 ( L ) resistant pathway for cytochrome c release . . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Mitochondrion harbors both antiapoptotic ( Bcl 2 , Bcl XL ) and apoptotic factors ( Smac / Diablo , Apaf 1 , cytochrome c ) . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Bcl xL was able to block cytochrome c release and apoptosis but failed to prevent mitochondrial fragmentation . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Molecular mechanisms of curcumin induced cytotoxicity : induction of apoptosis through generation of reactive oxygen species , down regulation of Bcl XL and IAP , the release of cytochrome c and inhibition of Akt . ^^^ Curcumin causes dose dependent apoptosis and DNA fragmentation of Caki cells , which is preceded by the sequential dephosphorylation of Akt , down regulation of the anti apoptotic Bcl 2 , Bcl XL and IAP proteins , release of cytochrome c and activation of caspase 3 . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Apoptosis was associated with the down regulation of bcl 2 family members bcl 10 ( L ) and bfl / A1 , and the activation of caspase 3 , that mediates bcl 2 cleavage , resulting in the release of cytochrome c from the mitochondria . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
With a serial of Western blot analysis , it is revealed that gossypol induced cell cycle arrest is involved in P 21 up regulation and cyclin D 1 down regulation ; gossypol induced apoptosis triggers down regulation of anti apoptosis Bcl 2 members : Bcl 10 ( L ) , Bag 1 and Mcl 1 , up regulation of pro apoptosis Bcl 2 member Bak , activation of caspase 3 , 6 , 7 , 8 , and 9 , up regulation of Apaf 1 , release of cytochrome c ( cyto c ) from mitochondria , and activation of both DFF 45 and PARP . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Induction of apoptosis by hydroxydibenzoylmethane through coordinative modulation of cyclin D 3 , Bcl 10 ( L ) , and Bax , release of cytochrome c , and sequential activation of caspases in human colorectal carcinoma cells . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
The protein contents of cytochrome c , procaspase 3 , caspase 3 , Bcl 10 ( L ) , and Bax were analyzed by Western blot and quantified by densitometry . ^^^ CONCLUSIONS : DLPC , at a dose contained in PPC , reproduces the antiapoptotic actions of PPC through a reduction in cytosolic cytochrome c concentration and caspase 3 activity , possibly in association with up regulation of Bcl 10 ( L ) expression . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Scavenging of mitochondrial superoxide anions by NO prevents the downregulation of bcl 10 ( L ) , the depolarization of the mitochondrial membrane potential , the cytochrome c release and finally the activation of caspase 3 . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Withdrawal of IL 3 caused down regulation of Bcl xL , resulting in a drop in mitochondrial membrane transition potential followed by the release of cytochrome c and endonuclease G from mitochondria . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Forced expression of Apaf 1 restored the competence to complete the cytochrome c induced apoptotic program and this effect was prevented by overexpression of Bcl 10 ( L ) . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Bcl 10 ( L ) expression delays , but does not totally block , the release of mitochondrial cytochrome c ( cyt c ) in these cells in response to TNFalpha induced apoptosis and caspase 9 is processed prior to mitochondrial cyt c release under these circumstances . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Coexposure to CD95L and SS prevents the CD95L evoked processing of caspases 2 , 3 , 8 and 9 , the release of cytochrome c from mitochondria , and the loss of BCL 10 ( L ) protein . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
As ( 2 ) O ( 3 ) induced apoptosis was associated with reduced deltapsi ( m ) , enhanced generation of intracellular ROS , decreased levels of intracellular GSH , release of cytochrome c and AIF from the mitochondria , activation of caspases , down regulation of Bcl 2 and Bcl 10 ( L ) , and up regulation of Bax expression . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
However , overexpression of bcl 10 ( L ) inhibits cytochrome c release from mitochondria . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Treatment of cells with tetrandrine caused the upregulation of p 53 , downregulation of Bcl 10 ( L ) , cleavage of Bid and Bax , and release of cytochrome c , which were accompanied by activation of caspases 9 , 3 and 8 . ^^^ These findings and data showing the early release of cytochrome c , cleavage of Bid and downregulation of Bcl 10 ( L ) suggest that the mitochondrial pathway is primarily involved in tetrandrine induced apoptosis . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Bcl 2 and Bcl xL overexpression inhibits cytochrome c release , activation of multiple caspases , and virus release following coxsackievirus B 3 infection . ^^^ Enforced Bcl 2 and Bcl xL expression markedly reduced release of cytochrome c , presentation of the mitochondrial epitope 7A6 , and depressed caspase activation following infection . ^^^ In comparison , cell death using TRAIL ligand caused caspase 8 processing prior to cytochrome c release and executioner caspases and cell death was only partially rescued by Bcl 2 and Bcl xL overexpression . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Overexpression of Bcl 2 and Bcl XL or N acetyl DEVD aldehyde treatment not only prevented the mitochondrial membrane potential decrease , but also protected cells from the apoptosis directly induced by cytochrome c electroloading . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
The intrinsic pathway is regulated by Bax and Bcl XL and involves Bax induced mitochondrial dysfunction and release of cytochrome c as antecedent events leading to caspase 3 activation . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Increased expression of Bcl 2 and Bax , but not of Bcl 10 , occurs in the penumbra at the time when Bax translocates from the cytosol to the mitochondria , cytochrome c is released to the cytoplasm and active caspase 3 is expressed . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
GDNF also protects against aluminum induced apoptosis but by upregulation of Bcl 10 ( L ) , thereby preventing the binding of cytochrome c to Apaf 1 . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
A PUMA BH 3 peptide can induce Bax conformational change , cytochrome c release , and reduction in the mitochondrial membrane potential ( DeltaPsi ( m ) ) in isolated K 562 mitochondria and can be inhibited by Bcl XL . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Antiapoptotic family proteins such as Bcl 2 and Bcl 10 ( L ) function , at least in part , by binding proapoptotic members such as Bax and Bak and thereby preventing release of apoptotic proteins , including cytochrome c , from the mitochondria . `` BH 3 only ' ' members of the family disrupt this interaction by binding , via their BH 3 domain , to a hydrophobic pocket on the surface of the antiapoptotic members . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
It has previously been shown that the BH 4 domain of Bcl 2 / Bcl xL is essential for the prevention of apoptotic mitochondrial changes , including the release of cytochrome c and apoptotic cell death . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
However , these thialysine induced apoptotic events were significantly abrogated by an ectopic expression of Bcl xL , which is known to block mitochondrial cytochrome c release . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Indeed , cytochrome c was not released to the cytosol ; Bax and caspase 9 and 3 were not involved ; overexpressed Bcl xL did not block the death ; and the mitochondrial ultrastructure was not changed . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
We detected several signs of an early apoptosis : lowering of Bcl xL expression , decrease of the mitochondrial and plasma membrane potential , the cytochrome c release into the cytoplasm , and the unmasking of the mitochondrial antigen 7A6 . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Bcl 10 ( L ) and / or mutated p 53 inhibit the apoptotic process by preventing the mitochondrial release of cytochrome c and / or activation of execution caspases . ^^^ Bcl 10 ( L ) significantly decreased the p 53 induced cytochrome c release , but not the apoptin triggered one . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
The underlying mechanism of action of SAH mediated inhibition of BCL XL ( and / or BCL 2 ) cell survival appears to be due to loss of mitochondrial integrity as reflected in enhanced cytochrome c release leading to the activation of caspase 9 and finally caspase 3 . . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
In addition , we discovered that transient expression of Bcl 2 , unlike its pro survival homolog Bcl 10 ( L ) , can lead to the release of cytochrome c from mitochondria and that the resulting cell death can be inhibited by caspase and calpain inhibitors . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
The propensity of mitochondria to undergo permeability transition in the presence of a Ca2+ overload was determined along with distribution of various apoptotic regulators ( AIF , Smac 2 , Bax , cytochrome c , Bcl XL , Bfl 1 , and caspase 2 ) between mitochondria and cytoplasmic fractions . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Additional unique oncogenic signals occur in pretumorigenic CD 45 ( / ) p 56 ( lck F505Y ) thymocytes in which p56lck kinase activity is 2 to 3 fold higher relative to p 56 ( lck F505Y ) : inhibition of DNA repair , inhibition of DNA damage induced Bcl XL deamidation , Bax conformational change and mitochondrial translocation , cytochrome c release , and the apoptotic caspase execution cascade . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
In contrast , the lack of mitochondrial transmembrane potential transition , release of cytochrome c and absence of caspase 9 and PARP cleavage showed a strong correlation with Bcl xL expression . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Within the first category , certain proteins ( e . g . , BCL 2 , BCL xL ) act to preserve mitochondrial integrity by preventing loss of mitochondrial membrane potential and / or release of pro apoptotic proteins such as cytochrome C into the cytosol . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Bcl 2 and Bcl xL antagonize apoptosis by blocking the release of caspase activators such as cytochrome c from mitochondria . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
K 562 R and LAMA R cells that were markedly resistant to induction of mitochondrial dysfunction ( e . g . loss of mitochondrial membrane potential , Bax translocation , cytochrome c , and apoptosis inducing factor release ) and apoptosis by imatinib mesylate exhibited a pronounced reduction in expression of Bcr / Abl , Bcl 10 ( L ) , and STAT 5 but a striking increase in levels of activated Lyn . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Bcl XL and Ku 70 protected the cells by inhibiting the release of cytochrome c , Smac ( second mitochondria derived activator of caspase ) and apoptosis inducing factor ( AIF ) , and the activation of caspases 9 , 8 and 3 triggered by curcumin . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Furthermore , we showed that release of mitochondrial cytochrome c , cleavage of caspase 9 and PARP during apoptosis in T . vaginalis treated RAW264 . 7 cells were considerably diminished by transfection with overexpressed Bcl 10 ( L ) , and overexpressed Bcl 10 ( L ) could inhibit T . vaginalis induced apoptosis in RAW264 . 7 cells . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
When grown in coculture with endothelial cells and exposed to LPS in coculture but harvested independently , pericytes showed decreased levels of p 11 and p 17 and increased levels of Bcl xL , an antiapoptotic protein that protects the integrity of mitochondria , and prevents cytochrome c release and subsequent caspase 9 activation . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
The apoptosis was associated with release of cytochrome c from the mitochondria and caspase activation , and was blocked by caspase inhibitors and the anti apoptotic proteins Bcl 2 , and Bcl 10 ( L ) , suggesting a role for mitochondrial pore formation . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Possibly as an adaptive response , total protein and mRNA levels of cytochrome c and of the anti apoptotic Bcl 2 family member , Bcl xl , increased . ^^^ The gene encoding cytochrome c carries the cAMP response element ( CRE ) , and the gene encoding Bcl xl carries both the CRE and NFkappaB response elements . ^^^ The inability of etoposide to trigger apoptosis in preconditioned cells was most likely because of prosurvival signaling by CREB and NFkappaB , which included up regulation of cytochrome c and Bcl xl . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
In addition , release of cytochrome c from mitochondria , down expression of Bcl 2 and Bcl 10 ( L ) , up regulation of Bax , and caspase 9 activities were observed in SM treated A 549 cells . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Knockdown of Bcl xL and administration of TRAIL significantly synergized in dissipation of mitochondrial membrane potential , release of cytochrome c , activation of caspase 9 and 3 and , consequently , apoptotic cell death . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Activation of different initiator and effector caspases , Bax and Bcl xL expression , mitochondrial cytochrome c release and activation of PKB / Akt were analyzed by use of synthetic caspase substrates and Western blotting , respectively . ^^^ In addition , cytochrome c release from mitochondria was efficiently repressed , which was associated with upregulation of Bcl xL by dexamethasone and activation of PKB / Akt by insulin . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Analysis of cytochrome c release also confirmed that in Bcl 2 or Bcl 10 ( L ) expressing cells apoptosis could be detected by terminal deoxynucleotidyl transferase mediated dUTP nick end labelling ( TUNEL ) assay before any evidence of mitochondrial membrane perturbation . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
The selective COX 2 inhibitor , NS 398 , potentiated the 2 , 2 ' , 4 , 6 , 6 ' PeCB induced mitochondrial apoptotic pathway involved in Bcl xL attenuation , cytochrome c release and the subsequent activation of caspase 3 . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
In addition , SM caused release of cytochrome c , downregulation of anti apoptotic Bcl 2 and Bcl xL , increase of caspase 3 activity , and DNA fragmentation . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Bcl 2 and Bcl XL inhibit apoptosis by binding to proapoptotic proteins such as Bax , thereby preventing chemotherapy induced or radiation induced release of cytochrome c from mitochondria and subsequent activation of the caspase protease cascade . ^^^ Peptides were quantitatively examined for their ability to inhibit Bax / Bcl 2 and Bax / Bcl XL heterodimerization in vitro and to promote cytochrome c release from mitochondria isolated from Jurkat , HL 60 , U 937 , and PC 3 cells . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Furthermore , Bcl xL co transfection significantly reduced the release of cytochrome c induced by galig expression , suggesting a common pathway between the cytotoxic activity of galig and the anti apoptotic activity of Bcl xL . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
The expression of Bcl 10 ( L ) protected MLEC against H / R induced cell death by blocking Bax and Bid translocation and inhibiting mitochondrial cytochrome c release . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
The apoptosis induced by hTid 1 ( S ) was accompanied by mitochondrial cytochrome C release and caspase activation and blocked by stable overexpression of Bcl 10 ( L ) . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
As expected ( ) gossypol induced complete cytochrome c release from mitochondria , increased caspases 3 and 9 activity , and caused apoptotic death without affecting protein levels of Bcl 2 , Bcl 10 ( L ) , Bax , and Bak . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Additionally , ( ) gossypol was more efficient than etoposide at inducing caspase 3 activation and phosphatidylserine externalization in the setting of Bcl 2 or Bcl 10 ( L ) overexpression . ( ) Gossypol induced apoptosis was associated with Bak activation and release of cytochrome c from mitochondria , suggesting a mitochondrial mediated apoptotic mechanism . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Curcumin induced release of cytochrome c , Second mitochondria derived activator of caspase ( Smac ) and apoptosis inducing factor ( AIF ) was also blocked in Bax / cells and reintroduction of Bax , downregulation of the antiapoptotic protein Bcl XL by antisense DNA as well as the overexpression of Smac , highly sensitized the Bax / cells toward curcumin induced apoptosis . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
The Bcl 2 family protein Bcl 10 ( L ) suppressed cytochrome c release as well as processing of procaspases 3 , 8 , and 9 in E 73 treated cells . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
As2O3 induced cell death coincides with cytochrome c release , facilitates mitochondrial permeability transition and is sensitive to inhibition by Bcl 10 ( L ) , indicating that cell demise is regulated through the mitochondrial apoptosis pathway . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
CONCLUSIONS : Because of NF kappaB inhibition with the combination of SN 38 and TNF , the expression of BCL XL ( both the protein [ Western blot analysis ] and the mRNA [ reverse transcriptase polymerase chain reaction analysis ] ) was down regulated , cytochrome c was released into the cytoplasm , caspase 3 was activated ( Western blot analysis ) , and , consequently , apoptosis was triggered . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Phospho ser 15 p 53 physically interacted with Bcl 2 and Bcl xL in mitochondria and its translocation into mitochondria preceded cytochrome c release and mitochondrial membrane potential ( MMP ) reduction . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
The antiapoptotic proteins , Bcl 2 and Bcl xl , were downregulated by GSP , whereas the expression of the pro apoptotic protein , Bax , and the levels of cytochrome c release , Apaf 1 , caspase 9 , and cleaved caspase 3 ( p 19 and p 17 ) were markedly increased in JB 6 C141 cells . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
In KNS 62 Bcl xL clones , release of cytochrome c and loss of mitochondrial transmembrane potential were suppressed . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Attenuating erbB signals in cultured neonatal rat cardiomyocytes by the erbB 2 antagonist tyrphostin AG 825 , by the erbB1 / 4 antagonist AG 1478 or by antisense induced lowering of erbB 2 receptors resulted in an augmented Bcl xS / Bcl xL ratio , mitochondrial release of cytochrome c , activation of caspase 9 and caspase 3 , and nucleosome sized DNA fragmentation . ^^^ A similar DNA fragmentation and caspase 3 activation was induced by TNF alpha , but without Bcl xS / Bcl xL increase , cytochrome c release or caspase 9 activation . ^^^ A BH 4 domain containing HIV TAT fusion protein added to cardiomyocytes under attenuated erbB signaling lowered the enhanced Bcl xS / Bcl xL ratio , the cytochrome c release , the caspase 3 activation and the DNA fragmentation , while apoptosis was not modified by the fusion protein in TNF alpha treated cardiomyocytes . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
MX 3350 1 decreased the levels of antiapoptotic Bcl 2 and Bcl XL , increased proapoptotic Bax , induced mitochondrial membrane permeabilization ( MMP ) , and cytochrome c release from mitochondria to cytosol . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
To characterize the mechanisms of apoptosis induction by proteasome inhibitors , we examined levels of Bcl 2 protein family members ( Bik / NBK , Bax , Bak , Bcl 2 , and Bcl XL ) , release of cytochrome c , and activation of caspase 9 and 3 in human colon cancer cell lines DLD 1 , LOVO , SW 620 , and HCT 116 ; human lung cancer cell line H 1299 ; and human ovarian cancer cell line SKOV 3 after they were treated with bortezomib . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
We discovered that there was high expression in the lens equatorial epithelium ( the region of the lens in which differentiation is initiated ) of pro apoptotic molecules such as Bax and Bcl 10 ( S ) and release of cytochrome c from mitochondria . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
DNA fragmentation was accompanied by the following phenomena : elevation in the level of hemeoxygenase 1 protein and thioredoxin reductase mRNA ; repression of Mn superoxide dismutase and catalase mRNAs ; release of cytochrome c from mitochondria into the cytosol ; activation of caspases 8 , 9 and 3 ; decrease in the level of Bcl 2 , Bcl XL and Bid protein ; increase in the level of Bad protein . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Increased ARTS in turn leads to a decrease of Bcl 2 and Bcl xL protein levels , cytochrome c release from mitochondria and apoptosis . . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Our gene expression profile data indicate that Zeocin treatment induces an initial release of cytochrome c , the down regulation of Bcl 10 ( L ) , ENDOG , DAXX and MDM 2 , and the up regulation of CASP and BID . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Bcl 10 ( S ) , a proapoptotic member of the Bcl 2 protein family , is localized in the mitochondria and induces apoptosis in a caspase and BH 3 dependent manner by a mechanism involving cytochrome c release . ^^^ The way in which Bcl 10 ( S ) induces caspase activation and cytochrome c release , as well as the relationship between Bcl 10 ( S ) and other proapoptotic members of the Bcl 2 family , is not known . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Accordingly , risedronate suppressed the phosphorylation of ERK 1 / 2 , a downstream survival signaling kinase of Ras , affected the intracellular distribution of Bcl xL , and induced the mitochondrial membrane depolarization , cytochrome c release , activated caspase cascade and DNA fragmentation . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
In order to understand the molecular alterations leading to heterogeneous cisplatin sensitivity and apoptosis inducibility in NSCLC cells , we analyzed various apoptotic pathways , including the activation of caspase 8 , 9 and 3 , the release of cytochrome c from mitochondria and the expression levels of pro and anti apoptotic proteins such as Bax , Bad , Bcl 2 , Bcl xL , Fas and p 53 using heterogeneously apoptosis sensitive cells ( Ma 10 , Ma 31 and Ma 46 ) . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Molecular events of apoptosis including degradation of chromosomal DNA , decrease in the level of Bcl xL , the disruption of mitochondrial membrane , cytosolic release of cytochrome c and activation of caspase 3 were elucidated . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Both caused apoptosis by increasing the protein expression of Bax and Bcl xs while decreasing Bcl 2 and Bcl 10 ( L ) , releasing apoptogenic cytochrome c , and augmenting the activity of caspase 9 and caspase 3 . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
These events were associated with : ( a ) reduced levels of the anti apoptotic protein Bcl 10 ( L ) , ( b ) the translocation of cytochrome c from the mitochondria to the cytosol , ( c ) the cleavage of pro caspase 9 and pro caspase 3 . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Furthermore , the release of cytochrome c but not Smac from mitochondria was induced by Bcl 10 ( L ) siRNA alone , and this release was dramatically amplified by combining the Bcl 10 ( L ) siRNA and TRAIL protein treatment . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Polyglutamine expanded ataxin 7 Q 75 promoted the release of apoptogenic cytochrome c and Smac from mitochondria , which was preceded by the downregulation of Bcl 10 ( L ) protein and upregulation of Bax protein expression in cultured cerebellar neurons . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Thus , the introduction of HBx into Hep3B cells induces apoptosis and sensitizes Hep3B cells to TNFalpha mediated cell killing , and these processes may accomplish through inhibiting Bcl xL expression and subsequently promoting cytochrome c release from mitochondria . . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
In heart transplantation , overexpression of Bcl xL inhibited Bax translocation from the cytosol to the mitochondria , resulting in decreased cytochrome c release from the mitochondria ; it also significantly decreased cardiac cell apoptosis and improved graft survival rate after long cold preservation , followed by warm reperfusion . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
We evaluated the levels of Bax , Bcl xL , Bcl 2 and cytochrome c expression by Western blot analysis , and caspase 9 and 3 activities were determined in a colorimetric assay . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Bax , Bcl 2 , Bcl XL , Bid , cytochrome c and PKCd were detected by Western blotting . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Molecular dissection revealed that Bcl 10 ( L ) inhibited the translocation of Bax to the mitochondria , decreased the generation of intracellular reactive oxygen species , reduced the mitochondrial transmembrane potential ( deltapsi ( m ) ) , decreased the release of cytochrome c , decreased the cleavage of poly ( ADP ribose ) polymerase , and eventually inhibited apoptotic cell death . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Ellipticine increased the expression of Bax , but decreased the level of Bcl 2 , Bcl XL and 10 linked inhibitor of apoptosis protein ( XIAP ) , and subsequently triggered the mitochondrial apoptotic pathway ( release of cytochrome c , and activation of caspase 9 and 3 ) . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
The release of cytochrome c and Bcl 10 ( L ) was detected by Western blot . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
The decrease of Bcl 2 and Bcl XL along with this oxidative stress caused release of mitochondrial cytochrome c into the cytosol and subsequent induction of pro caspase 9 processing . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Apoptosis by I3C involves downregulation antiapoptotic gene products , including Bcl 2 , Bcl xL , survivin , inhibitor of apoptosis protein ( IAP ) , 10 chromosome linked IAP ( XIAP ) , and Fas associated death domain protein like interleukin 1 beta converting enzyme inhibitory protein ( FLIP ) ; upregulation of proapoptotic protein Bax ; release of micochondrial cytochrome C ; and activation of caspase 9 and caspase 3 . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
In contrast , IFNgamma pretreatment prevented Bcl xL gene up expression in TNFalpha stimulated cells and allowed cytochrome c release . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NaBt treatment results in a marked down regulation of Bcl xL expression , mitochondrial membrane depolarization , cytochrome c release from mitochondria , activation of caspase 9 and 3 and apoptosis induction . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Ataxin 3 Q 79 promoted mitochondrial release of cytochrome c and Smac , which was preceded by the upregulation of Bax protein and downregulation of Bcl 10 ( L ) protein expression . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
We found that the intrinsic pathway is activated early on during anesthesia exposure ( within two hours ) , as measured by the down regulation of bcl 10 ( L ) , up regulation of cytochrome c and the activation of caspase 9 in 7 day old rats ( the peak of synaptogenesis ) , but remains inactivated in 14 day old rats ( the end of synaptogenesis ) . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
The number of apoptotic cells in lung sections was determined by a TUNEL method . mRNAs for Fas , FasL and caspase 8 , and for Bad , Bax , Bcl w , Bcl xL and caspase 9 , for the FasL and the mitochondrial cytochrome c pathways of apoptosis , respectively , and mRNA for the effector caspase 3 were quantified in lung tissues by RT PCR . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Moreover , berberine induced the activation of caspase 8 and 3 , and caused the cleavage of poly ADP ribose polymerase ( PARP ) and the cytochrome c release , whereas the expression of Bid and anti apoptosis factor Bcl XL were decreased markedly . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Furthermore , we show that this occurs through inhibition of nitric oxide induced release of cytochrome c from mitochondria and by blocking both the nitric oxide induced suppression of the antiapoptotic protein , Bcl xL , and the phosphorylation of Akt . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Coadministration of flavopiridol with HDAC inhibitors synergistically potentiated mitochondrial damage ( cytochrome c , second mitochondria derived activator of caspases / direct IAP binding protein with low pI , and apoptosis inducing factor release ) , caspase activation , poly ( ADP ribose ) polymerase degradation , and cell death in both wild type and Bcl 2 or Bcl 10 ( L ) overexpressing cells and induced a pronounced loss of clonogenicity . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Tetrandrine treatment led to significant release of cytochrome c and downregulation of Bcl 10 ( L ) accompanied by caspase 3 activation , and ultimately , DNA fragmentation . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Coimmunoprecipitation experiments were designed to study Bcl XL / Bim heterodimerization , and Western blots to study cytochrome c release . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
HDAC inhibitors enhance the apoptosis inducing potential of TRAIL in leukemia cells ( HL 60 , Jurkat , K 562 , and U 937 ) through multiple mechanisms ; up regulation of DR 4 , DR 5 , Bak , Bax , Bim , Noxa and PUMA , down regulation of IAPs , Mcl 1 , Bcl 2 , Bcl XL and cFLIP , release of mitochondrial proteins ( cytochrome c , Smac / DIABLO and Omi / Htr2 ) to the cytosol , induction of p21WAF1 / CIP1 and p27KIP1 , activation of caspase 3 and cleavage of poly ( ADP ribose ) polymerase ( PARP ) . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Melatonin induced neuroprotection was mediated , at least in part , via the inhibition of mitochondria dependent apoptotic pathway since melatonin caused an up regulation of the anti apoptotic protein , bcl 10 ( L ) , reduction in anesthesia induced cytochrome c release into the cytoplasm and a decrease in anesthesia induced activation of caspase 3 , an important step in the activation of DNAses and the formation of the apoptotic bodies . . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
A preparation of mitochondria heated at 43 degrees C released cytochrome c in association with Bak oligomerization , and Bcl xL prevented these events . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
The levels of adenine nucleotide translocator , voltage anion dependent channel , Bax , Bcl 2 , Bcl xL , AIF and Smac / Diablo , were similar in both cell lines , whereas cytochrome c content was divided by three in the resistant cells . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Ad COX 1 / PGIS transfection was found to reduce the adriamycin stimulated activities of caspase 3 and caspase 9 , inhibit adriamycin induced release of cytochrome c , elevate the expression of Bcl 10 ( L ) , and suppress the activation and translocation of nuclear factor kappaB ( NF kappaB ) in adriamycin treated renal tubular cells . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Apoptosis was accompanied by cytochrome c release to the cytoplasm and Bax translocation to the mitochondria , while the levels of the anti apoptotic proteins Bcl 2 and Bcl xL remained unchanged . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Both PUNI and EA provoked the same effects on Caco 2 cells : down regulation of cyclins A and B 1 and upregulation of cyclin E , cell cycle arrest in S phase , induction of apoptosis via intrinsic pathway ( FAS independent , caspase 8 independent ) through bcl XL down regulation with mitochondrial release of cytochrome c into the cytosol , activation of initiator caspase 9 and effector caspase 3 . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
The mitochondrial translocation of Bcl XS and its interaction with the pore forming voltage dependent anion channel ( VDAC ) correlates with the redistribution of cytochrome c and the cleavage of Poly ( ADP ribose ) polymerase . ^^^ Pathological relevance is demonstrated by the cytotoxic synergism between HAL and the Alzheimer disease related peptide beta amyloid ( 1 40 ) , which correlates with Bcl XS expression and its interaction with VDAC , and with cytosolic cytochrome c translocation . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
However , the HaBC 18 induced apoptosis was abrogated by an ectopic overexpression of Bcl xL , which is known to block mitochondrial cytochrome c release . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Death promoting Bcl 2 family members , such as Bax , can promote cytochrome c release and fragmentation of the mitochondrial network , whereas apoptosis inhibitory members , such as Bcl 2 and Bcl xL , can antagonize these events . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Cell death was associated with a decrease and increase in Bcl 10 ( L ) and Bax expression , respectively , as well as release of cytochrome c and translocation of apoptosis inducing factor . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
RESULTS : Our results indicated that combined treatment led to an increased apoptotic cell death in U 937 cells , which is correlated with the phosphorylation of the 5 Jun sarcoma virus 17 oncogene homolog ( c JUN ) NH ( 2 ) terminal kinase protein ( JNK ) , the activation of caspases , the increase in B cell leukemia / lymphoma 2 ( Bcl 2 ) associated 10 protein ( Bax ) , the decrease in Bcl xL protein ( Bcl XL ) levels , the loss of mitochondria membrane potential and the release of cytochrome c . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
RESULTS : Cotreatment of Bcr / abl ( + ) cells with minimally toxic concentrations of DMAG and PD 184352 resulted in synergistic induction of mitochondrial injury ( cytochrome c release and Bax conformational change ) , events associated with the pronounced and sustained inactivation of ERK1 / 2 accompanied by down regulation of Bcl 10 ( L ) . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
The protein expressions of Bcl XL , Bcl 2 , Bax , cytochrome c and AIF were studied by Western blotting . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
In rat primary neurons and human postmitotic neuronal cells , the Abeta peptide induced a dose dependent neuronal death , reduced the levels of the anti apoptotic protein Bcl XL , enhanced the cytosolic release of cytochrome c , and elicited the intracellular accumulation and secretion of Abeta 42 oligomers . ^^^ The kappaB decoy also inhibited the Abeta induced release of cytochrome c , restored the levels of Bcl XL , and prevented intraneuronal accumulation and secretion of Abeta 42 . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
DFMO inhibits several of the molecular events of apoptosis that follow simulated ischemia , such as the release of cytochrome c from mitochondria , caspase activation , downregulation of Bcl xL , and DNA fragmentation . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Bcl xL is an anti apoptotic protein that inhibits apoptosis by preventing release of cytochrome c , a recognised pathway to cell death . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Levels of Beclin 1 , Bcl 10 ( L ) and cytochrome c , and the cleavage of poly ( ADP ribose ) polymerase ( PARP ) were assayed by using Western blots . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Inhibition of the intrinsic apoptosis pathway was suggested by decreases in the proapoptotic protein Bax and mitochondrial cytochrome c release , and an increase in the antiapoptotic protein Bcl 10 ( L ) . ^^^ Injected antibodies to FGF 1 and FGF 2 had no effect on DNA synthesis , but both increased Bcl 10 ( L ) content and decreased cytochrome c release and cleaved caspase 7 protein expression . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
A large amount of Adv Casp 8 ( MOI of 50 ) induced apoptosis significantly in HCC cells and resulted in downregulation of c FLIP ( in SK Hep 1 , HLE , and HepG 2 cells ) , XIAP , survivin , and Bcl xL ( in HLE cells ) and dynamic release of cytochrome c and Smac from the mitochondria into the cytosol . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Bcl 2 , Bcl 10 ( L ) ) proteins that regulate mitochondrial outer membrane integrity , cytochrome c release and caspase activation . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
The protein expression ratio of Bcl xL / Bax and Bcl 2 / Bax was down regulated and uncarinic acid E induced apoptosis involves the initial phase mediated by the balance among Bcl xL , Bcl 2 and Bax proteins , resulting in cytochrome c release from the mitochondria . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
AMR induced apoptosis was accompanied by redistribution of cytochrome c from mitochondria to cytosol as well as down regulation of Bcl 2 and Bcl 10 ( L ) proteins in a dose dependent manner . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
Truncated Atg 5 translocated from the cytosol to mitochondria , associated with the anti apoptotic molecule Bcl xL and triggered cytochrome c release and caspase activation . ^^^
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: P99999 and Q07817	Pubmed	SVM Score :0.0
NA