| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| It shares a conserved domain , BH 3 , with other pro apoptotic proteins , Bax , Bak , Bid , and Hrk , and certain anti apoptosis proteins such as Bcl 2 and Bcl xL . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Deletion of BH 4 rendered Bcl 2 ( and Bcl xL ) inactive but did not impair either Bcl 2 homodimerization or ability to bind to Bax or five other pro apoptotic relatives ( Bak , Bad , Bik , Bid or Bim ) . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Surface plasmon resonance was used to examine the kinetics of dimerization as a function of pH between the anti apoptotic protein Bcl XL ( applied in the mobile phase ) and three other members of the Bcl 2 family : Bcl 2 , Bax , and Bid ( immobilized on biosensor chips ) . ^^^ In all cases , the relative affinity of dimerization was substantially increased at pH 4 . 0 compared to pH 7 . 0 7 . 4 , ranging from a approximately 10 fold enhancement for Bcl XL / Bcl XL homodimers to > 60 fold for Bcl XL / Bid heterodimers . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Caspase cleaved BID targets mitochondria and is required for cytochrome c release , while BCL XL prevents this release but not tumor necrosis factor R1 / Fas death . `` BH 3 domain only ' ' members of the BCL 2 family including the pro apoptotic molecule BID represent candidates to connect with proximal signal transduction . ^^^ In the presence of BCL XL / BCL 2 , TNFalpha still induced BID cleavage and p 15 BID became an integral mitochondrial membrane protein . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Bcl xL can inhibit the effect of Bid by interacting directly with Bax . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Furthermore , we modeled a complex of BCL XL and BID by aligning the BID and BAK BH 3 motifs in the known BCL XL BAK BH 3 complex . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Secondary structure and fold predictions suggest that BID has a high degree of alpha helical content and structural similarity to Bcl 10 ( L ) , which itself is highly similar to bacterial pore forming toxins . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Interestingly , the L35A Bid mutant is as effective as t ( c ) Bid in inducing apoptosis and binding Bcl 10 ( L ) . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| We also show by Western blot that Bcl xL , caspase 9 , caspase 8 , and Bid are processed by caspase 3 in injected wild type mice but that this processing does not occur in caspase 3 / mice . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Caspases are known to cleave Bid , a proapoptotic family member , as well as Bcl 2 and Bcl 10 ( L ) , two prosurvival family members , which activate their cytotoxic activity resulting in the release of cytochrome c from mitochondria . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| However , unlike the caspase cleavage products of cellular Bcl 2 , Bcl 10 ( L ) , and Bid , which are potent inducers of apoptosis , the cleavage product of gammaHV 68 Bcl 2 lacked proapoptotic activity . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| It is found that the most likely structural model of BID is built on the structure of Bcl 10 ( L ) . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Biochemical characterization indicates that this occurs via mechanisms that may include 1 ) activation of the phosphatidylinositol 3 kinase / protein kinase B pathway , resulting in phosphorylation and blockade of the proapoptotic functions of BAD ; 2 ) up regulation of the antiapoptotic protein Bcl xL ; and 3 ) inhibition of the cleavage of BH 3 interacting domain death agonist ( BID ) . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| The dependence on Bid , and thus on the mitochondrial cytochrome c release , of hepatocyte apoptosis induced by the death receptors also renders it sensitive to the inhibitory regulation by the anti apoptosis members of the Bcl 2 family proteins , such as Bcl 2 and Bcl xL . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Expression of Bcl 10 ( L ) and Bid decreased significantly in the cadmium treated cells , although no apparent change in Bcl 2 and Bax expression was found . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Overexpression of Bcl 10 ( L ) prevented the processing of caspase 8 as well as caspase 9 , 6 and Bid in response to drugs , but was less effective in CD 95 induced apoptosis . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| The release of cytochrome c can be influenced by different Bcl 2 family member proteins , including , but not limited to , Bax , Bid , Bcl 2 , and Bcl 10 ( L ) . ^^^ Bax and Bid potentiate cytochrome c release , whereas Bcl 2 and Bcl 10 ( L ) antagonize this event . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| However , caspase activation mediates cleavage of Bid and Bcl xL that could originate an amplification loop on the mitochondrial events . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Moreover , Bid cleavage precedes the initial cytochrome c release , whereas the late , amplified cytochrome c release coincides with changes in levels of Bcl 2 , Bcl 10 ( L ) , and reduction of mitochondrial membrane potential . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Curcumin ( diferuloylmethane ) induces apoptosis through activation of caspase 8 , BID cleavage and cytochrome c release : its suppression by ectopic expression of Bcl 2 and Bcl xl . ^^^ Curcumin treatment also induced BID cleavage and mitochondrial cytochrome c release in neo cells but not in Bcl 2 and Bcl xl transfected cells . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Dynamics of expression of apoptosis regulatory proteins Bid , Bcl 2 , Bcl 10 , Bax and Bak during development of murine nervous system . ^^^ We have used immunohistochemistry and immunoblotting to examine the expression of Bid and four other Bcl 2 family proteins ( Bcl 2 , Bcl 10 , Bax and Bak ) in the developing and adult murine central nervous system ( CNS ) . ^^^ Among the Bcl 2 family proteins only Bid and Bcl XL continue to be expressed at high levels in the adult brain . . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Ectopic expression of Bcl 2 and Bcl xL inhibits apoptosis induced by TNF related apoptosis inducing ligand ( TRAIL ) through suppression of caspases 8 , 7 , and 3 and BID cleavage in human acute myelogenous leukemia cell line HL 60 . ^^^ TRAIL also induced cleavage of BID , which was also abolished by Bcl 2 and Bcl xL . ^^^ Overall , these results indicate that TRAIL induced apoptosis involves activation of caspase 8 , caspase 7 , caspase 3 , and BID cleavage , and Bcl 2 and Bcl xL prevents TRAIL induced apoptosis by abrogating caspase activation and BID cleavage . . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| This channel forming activity requires an interaction between cut Bid and Bax , and is inhibited by Bcl 10 ( L ) . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| In vitro both ubiquitous calpains cleaved recombinant Bcl 2 , Bid , and Bcl 10 ( L ) at single sites truncating their N terminal regions . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Four molecules of the Bd 2 family ( BID , Bcl 2 , Bax , Bcl 10 ( L ) ) have been reported to be deaved during apoptosis , as has a cellular inhibitor of apoptosis ( XIAP ) . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| We observed no detectable changes in the steady state levels of Bcl 10 ( L ) , Bax , and Bid , although TNF suppresses Bcl 2 expression . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| The phosphorylation state of antiapoptotic ( Bcl 2 , Bcl 10 ( L ) ) and proapoptotic ( BAD , Bid , Bik ) Bcl 2 proteins regulates their cellular activity and , therefore , cell survival and cell death . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| The levels of anti apoptotic proteins Bcl 2 and Bcl 10 ( L ) were increased , and the cellular levels of pro apoptotic proteins Bid and Bax were reduced . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| The release of cytochrome c is the central gate in turning on / off apoptosis , and is regulated by the interaction of proapoptotic proteins , including Bid , Bax and Bak , and antiapoptotic proteins including Bcl 2 and Bcl 10 ( L ) , and a specific class of inhibitors of apoptosis proteins ( IAPs ) including Akt , survivin , and heat shock proteins . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Bcl 2 members can either be anti ( Bcl 2 , Bcl 10 ( L ) , Bcl w ) or pro apoptotic ( Bax , Bak , Bid , Bad , Bcl 10 ( S ) ) . ^^^ The expression of the pro apoptotic members Bax , Bak , Bid , and Bcl 10 ( S ) was significantly ( P < 0 . 05 ) decreased after TPN . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| The release of cytochrome c can be influenced by different Bcl 2 family member proteins , including Bax , Bid , Bcl 2 , and Bcl 10 ( L ) . ^^^ Bax and Bid potentiate cytochrome c release , whereas Bcl 2 and Bcl 10 ( L ) antagonize this event . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Whereas IL 4 and PPARgamma ligands failed to induce cleavage of Bid and release of cytochrome c from mitochondria , they caused translocation of the proapoptotic protein Bax from cytoplasm to mitochondria with a concomitant decrease in the Bcl 10 ( L ) level . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| We did not observe a protective effect of Bcl 10 ( L ) or Bcl 2 against the cytotoxic activity of TRAIL , even though TRAIL induced cleavage of BID . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| However , SK BR 3 breast tumour cells exhibiting increased expression level of Bcl 10 ( L ) were resistant to TRAIL , though upon exposure to TRAIL , caspase 8 and Bid were activated . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Bcl xL did not inhibit the early activation of caspase 8 ( < 4 h ) but inhibited cleavage of Bid , suggesting that Bid is cleaved downstream of the mitochondria , independent of caspase 8 . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| It was revealed that LIGHT treatment resulted in down regulation of anti apoptosis Bcl 2 family member : Bcl 2 , Bcl 10 ( L ) , Bag 1 , and Mcl 1 ; up regulation of pro apoptosis Bcl 2 family member : Bak and Ser ( 112 ) phosphor Bad ; down regulation of pro apoptosis Bcl 2 member Bax ; the other pro apoptosis member Bid remains unaltered . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Antisense oligonucleotide inhibition of Bcl xL and Bid expression in liver regulates responses in a mouse model of Fas induced fulminant hepatitis . ^^^ In the present study , we have examined the roles played by the Bcl 2 family members Bcl xL and Bid in regulating this response . ^^^ To do this , we have developed chemically modified 2 ' O ( 2 methoxy ) ethyl antisense inhibitors of both Bid and Bcl xL expression . ^^^ Simultaneous dosing of mice with Bcl xL and Bid targeting antisense oligonucleotides resulted in an inhibition of expression of both targeted proteins and protection of the animals from Fas mediated apoptosis . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Treatment of cells with tetrandrine caused the upregulation of p 53 , downregulation of Bcl 10 ( L ) , cleavage of Bid and Bax , and release of cytochrome c , which were accompanied by activation of caspases 9 , 3 and 8 . ^^^ These findings and data showing the early release of cytochrome c , cleavage of Bid and downregulation of Bcl 10 ( L ) suggest that the mitochondrial pathway is primarily involved in tetrandrine induced apoptosis . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| TUNEL staining revealed that the apoptotic cells were primarily hepatocytes . mRNA levels of all NF kappaB induced activators ( Fas , bid ) and inhibitors ( A 1 , BCl xl , cIAP 2 ) of both apoptotic pathways were significantly increased in liver tissue of BD donors versus non BD controls . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Interestingly , we found that the elevated expression of FLIP , Bcl 10 ( L ) and IAP in parallel with a downregulation of FADD and Bid was common for the resistant cell lines . ^^^ Consequently , stable overexpression of XIAP , Bcl 10 ( L ) or dominant negative FADD in sensitive cells significantly reduced the death receptor mediated apoptosis while the overexpression of Bid rendered the resistant cells sensitive . . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| This family of proteins now includes both anti apoptotic molecules such as Bcl 2 and Bcl 10 ( L ) , and pro apoptotic molecules such as Bax , Bak , Bid , and Bad . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Coadministration of tumor necrosis factor ( TNF ) related apoptosis inducing ligand ( TRAIL ) or TNF alpha substantially increased MEK inhibitors ( e . g . , PD 184352 or U 0126 ) / UCN 01 induced mitochondrial dysfunction , activation of procaspase 8 and Bid , and apoptosis in Bcl 2 and Bcl xL overexpressing cells but not in those in which the extrinsic pathway was interrupted . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Paclitaxel down regulated the expression of Bcl 10 ( L ) , Mcl 1 , and cellular inhibitor of apoptosis protein 1 antiapoptotic proteins and up regulated Bid and Apaf 1 . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Caspase 8 and Bid were cleaved in Colo 357 cells exposed to gemcitabine , and there was no correlation with either Bcl xL or with Bax expression . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| We further demonstrated that such a sensitive effect could be offset by Bcl xL , as Bid or tBid induced apoptosis was completely blocked by the over expression of Bcl xL . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Here , we report on the membrane insertion properties of different segments from antiapoptotic Bcl 10 ( L ) and proapoptotic Bax and Bid , that correspond to defined alpha helices in the structure of their soluble forms . ^^^ Surprisingly , the amphipathic helices alpha 6 of Bcl 10 ( L ) and Bax and alpha 7 of Bid do insert in membranes only as part of the alpha 5 alpha6 ( Bcl 10 ( L ) and Bax ) or alpha 6 alpha7 ( Bid ) hairpins but not when assayed individually . ^^^ Membrane insertion fragments of Bcl xL , Bax , and Bid . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| MATERIALS AND METHODS : The combined immunohistochemical expression levels of the proteins bax , bak , bad , bid , bcl 2 and bcl xl were evaluated by cluster and discriminant analysis . ^^^ RESULTS : Cluster analysis produced : a ) a low expression ( 69 / 79 cases ) and a high expression pro apoptotic cluster ( 10 / 79 cases ) for the combined expression levels of the pro apoptotic proteins bax , bak , bad and bid and b ) a low expression ( 37 / 76 cases ) and a high expression antiapoptotic cluster ( 39 / 76 cases ) for the combined expression levels of anti apoptotic proteins bcl 2 and bcl xl . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| The expression of Bcl 10 ( L ) protected MLEC against H / R induced cell death by blocking Bax and Bid translocation and inhibiting mitochondrial cytochrome c release . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Combined exposure to flavopiridol and HA 14 1 was associated with down regulation of Mcl 1 and Bcl xL , Bid cleavage , and mitochondrial translocation of Bax . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Here we showed that , besides the specific cleavage and activation of Bid by caspase 8 and caspase 3 , TRAIL induced apoptosis in Jurkat T cells required the specific cleavage of Mcl 1 at Asp 127 and Asp 157 by caspase 3 , while other prototypic antiapoptotic factors such as Bcl 2 or Bcl 10 ( L ) seemed not to be affected . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Inhibition of apoptosis closely correlated with sequestration of Bax , Bid and BAD in the mitochondrial inner membrane , increased Bcl 2 and Bcl 10 ( L ) , and inability to process p 21 Bid . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Specifically , we observe that Abeta significantly reduces expression of antiapoptotic Bcl w and Bcl 10 ( L ) , mildly affects expression of bim , Bcl 2 , and bax , but does not alter expression of bak , bad , bik , bid , or BNIP3 . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| B [ a ] P , B [ a ] P 7 , 8 DHD and BPDE 1 induced an accumulation and phosphorylation of p 53 , while the Bcl 2 proteins Bcl xl , Bad and Bid were down regulated . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Interestingly , apoptotic +SA cells showed a paradoxical decrease in mitochondrial levels of pro apoptotic proteins Bid , Bax , and Bad , and a corresponding increase in mitochondrial levels of anti apoptotic proteins , Bcl 2 and Bcl xL , suggesting that mitochondrial membrane stability and integrity might actually be enhanced for a limited period of time following acute tocotrienol exposure . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Indeed , bortezomib induced increases of Bik and / or Bim in multiple cell lines but not notably of two other BH 3 only proteins ( Puma and Bid ) nor other family members ( Bax , Bak , Bcl 2 , and Bcl xL ) . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| DNA fragmentation was accompanied by the following phenomena : elevation in the level of hemeoxygenase 1 protein and thioredoxin reductase mRNA ; repression of Mn superoxide dismutase and catalase mRNAs ; release of cytochrome c from mitochondria into the cytosol ; activation of caspases 8 , 9 and 3 ; decrease in the level of Bcl 2 , Bcl XL and Bid protein ; increase in the level of Bad protein . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Our gene expression profile data indicate that Zeocin treatment induces an initial release of cytochrome c , the down regulation of Bcl 10 ( L ) , ENDOG , DAXX and MDM 2 , and the up regulation of CASP and BID . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Meanwhile , Bcl xL was upregulated , and Bid activation or translocation , or conformational changes of Bax were not identified . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Proteins for Western blot analysis included Fas associated death domain ( FADD ) and caspase 8 for extrinsic pathway , as well as Bcl 2 , Bcl XL , Bax , Bad , Bid , Akt , p Akt , and caspase 9 for intrinsic pathway . ^^^ Levels of FADD , Bax , Bad , and Bid were substantially increased in the TA induced myopathy group , whereas Bcl 2 , Bcl XL , Akt , p Akt , and caspase 9 did not change between control and myopathy groups . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Bax , Bcl 2 , Bcl XL , Bid , cytochrome c and PKCd were detected by Western blotting . ^^^ A decreased expression of Bid was noted , although no significant changes in Bax , Bcl 2 and Bcl XL expression were observed after the combined treatment . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| TRAIL induced caspase 8 activation , Bid processing , drop of DeltaPsi ( m ) , and poly ADP ribose polymerase ( PARP ) cleavage but not in caspase 9 activation , and these events were inhibited in HER2 / PI3K / Akt suppressed BT 474 cells , which on the other hand exhibited downregulation of Bcl xL and increased response to mitomycin C . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| The results showed that Bcl 2 family molecules , such as Bid , Bak , and Bax , are involved in the parthenolide induced apoptosis and that the defective expression of Bcl 10 ( L ) might contribute to the higher parthenolide sensitivity in the SCK cells than in the other adenomatous cholangiocarcinoma cells . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Moreover , berberine induced the activation of caspase 8 and 3 , and caused the cleavage of poly ADP ribose polymerase ( PARP ) and the cytochrome c release , whereas the expression of Bid and anti apoptosis factor Bcl XL were decreased markedly . ^^^ These findings supported the fact that the inhibitors of caspases , DEVD FMK , IETD FMK and VAD FMK , prevented apoptosis and restored the expression of Bcl XL , Bcl 2 and Bid . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Up regulation of Bad and p 21 ; down regulation of Bcl 2 , Bcl XL , Bid , p 53 , and fatty acid synthase ; and cleavage of Bax were found in HMDB treated A 431 cells . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Chi square analysis revealed no association between expression of Bcl 2 , Bcl XL , Bad , Bak , Bid or p 53 proteins and response to vinorelbine therapy . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| In order to analyse the relationships between regulation of apoptosis and homologous recombination ( HR ) , we overexpressed proapoptotic Bax or only BH 3 Bid proteins or antiapoptotic Bcl 2 or Bcl XL , in hamster CHO cells or in SV 40 transformed human fibroblasts . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| After treatment with oridonin for 48 hr , the percentage of disruption of delta psi m gradually increased in a dose dependent manner along with marked changes of cell apoptosis , and necrotic cells increased remarkably after the cells were treated with oridonin for 72 hr ; Western blotting showed cleavage of the caspase 3 zymogen protein ( 32 kDa ) with the appearance of its 20 kDa subunit when apoptosis occurred ; expression of Bcl 2 and Bcl XL was downregulated remarkably while expression of Bax and Bid was upregulated concurrently after the cells were treated with oridonin for 24 hr . ^^^ We therefore conclude that oridonin has significant antiproliferation effects on HPB ALL cells by induction of apoptosis as well as directly causing cell necrosis and that oridonin induced apoptosis on HPB ALL cells is mainly related to the disruption of delta psi m and activation of caspase 3 as well as downregulation of anti apoptotic protein Bcl 2 , Bcl XL , and upregulation of pro apoptotic proteins Bax and Bid . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| These studies confirmed that a region of 16 residues of the BID BH 3 peptide is responsible for its strong binding to BCL w and BCL 10 ( L ) . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| These responses on UVB and / or sanguinarine treatments were associated with ( a ) decrease in Bcl 2 and Bcl 10 ( L ) and ( b ) increase in Bax , Bid , and Bak protein levels . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemistry was employed to examine the expression of the antiapoptotic proteins Bcl 2 and Bcl XL and the proapoptotic proteins Bad , Bak , Bax , Bid , Bim , and p 53 in 21 cases of gastric cancer . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Among proapoptotic proteins , Bax expression was activated in H ( 2 ) S treated cells but not Bid , and the antiapoptotic proteins Bcl 10 ( L ) and Bcl 2 did not show any activation in pancreatic acinar cell apoptosis . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| There was no evidence that calpain cleaved Bcl 2 family member proteins that regulate mitochondrial membrane permeability including Bcl 2 , Bcl xl , Bad , Bak , Bid , or Bim . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Statistically significant differences between epithelial and sarcomatoid tumours were observed for Bid ( p < 0 . 001 ) , Bad ( p = 0 . 012 ) and Bcl XL ( p = 0 . 03 ) . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Combined treatments increased the activation of caspases and Bid , and the inactivation of the anti apoptotic proteins XIAP , Bcl 10 , RIP , and survivin , thereby increasing the pro to anti apoptotic protein ratio . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| In these models , both SAHA and m carboxycinnamic acid bis hydroxamide induced growth arrest and caspase mediated apoptosis and increased p 21 protein levels , retinoblastoma hypophosphorylation , BH 3 interacting domain death agonist cleavage , Bax up regulation , down regulation of Bcl 2 , A 1 , and Bcl 10 ( L ) expression , and cleavage of poly ( ADP ribose ) polymerase and caspase 8 , 9 , 3 , 7 , and 2 . ^^^ |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55957 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|