Pubmed abstracts for Protein-Protein Interaction search result :


Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.98575235
These experiments demonstrate that Bcl XL associates with caspase 9 and Apaf 1 , and show that Bcl XL inhibits the maturation of caspase 9 mediated by Apaf 1 , a process that is evolutionarily conserved from nematodes to humans . . 0.98575235^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
Caspase 9 , Bcl XL , and Apaf 1 form a ternary complex . ^^^ An equivalent ternary complex was found to be present in mammalian cells involving Apaf 1 , the mammalian death protease caspase 9 , and Bcl XL , an anti apoptotic member of the Bcl 2 family . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
Thus , Diva represents a novel type of proapoptotic Bcl 2 homologue that promotes apoptosis independently of the BH 3 region through direct binding to Apaf 1 , thus preventing Bcl XL from binding to the caspase 9 regulator Apaf 1 . . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
We also show by Western blot that Bcl xL , caspase 9 , caspase 8 , and Bid are processed by caspase 3 in injected wild type mice but that this processing does not occur in caspase 3 / mice . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
Overexpression of F1Aalpha induces apoptosis in mammalian cells , and co expression of Bcl XL or the dominant negative mutants of either FADD or caspase 9 blocks this effect . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
Bcl xL inhibited processing of caspase 9 , Ac DEVD MCA cleavage activity and DNA fragmentation induced by RA / BMP 4 treatment . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
Apoptosis was attenuated in both conditions in stable transfected cells expressing antiapoptotic proteins Bclx ( L ) and catalytically inactive caspase 9 , and in both scenarios inactive caspase 9 became complexed with caspase 7 . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
Previous reports have suggested at least two distinct mechanisms : Bcl 2 and Bcl xL may inhibit either the formation of the cytochrome c / Apaf 1 / caspase 9 apoptosome complex ( by preventing cytochrome c release from mitochondria ) or the function of this apoptosome ( through a direct interaction of Bcl 2 or Bcl xL with Apaf 1 ) . ^^^ These observations , together with previous results obtained with Bcl 2 , argue that Bcl xL and Bcl 2 can not block the apoptosome mediated activation of caspase 9 . . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
Caspase 9 is autoprocessed by the Apaf 1 / cytochrome c pathway and acts at an early point in this cascade , whereas Bcl xL , an antiapoptotic member of the Bcl 2 family , prevents activation of caspases in vitro . ^^^ Little is known , however , about the relation between caspase 9 and Bcl xL during development of the mammalian nervous system . ^^^ We show that Bcl xL protects against caspase 9 and / or caspase 3 dependent apoptosis in the caudal portion of the ventral hindbrain , anterior horn cells , and dorsal root ganglia neurons of the normal mouse embryos and against caspase 9 / caspase 3 independent apoptosis in the dorsal region of the nervous system including the dorsal spinal cord . ^^^ Furthermore , we demonstrate that Bcl xL blocks cytochrome c release from mitochondria , causing activation of caspase 9 in anterior horn cells and dorsal root ganglia neurons in mouse embryos at embryonic day 11 . 5 . . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
Overexpression of Bcl 10 ( L ) prevented the processing of caspase 8 as well as caspase 9 , 6 and Bid in response to drugs , but was less effective in CD 95 induced apoptosis . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
Despite its lack of response to caspase inhibitors and Bcl 10 ( L ) , we show that this form of cell death is driven by an alternative caspase 9 activity that is Apaf 1 independent . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
Bcl 10 ( L ) caspase 9 interactions in the developing nervous system : evidence for multiple death pathways . ^^^ Targeted disruption of bcl 10 ( L ) , an antiapoptotic bcl 2 gene family member , causes massive death of immature neurons in the developing nervous system whereas disruption of caspase 9 , a proapoptotic caspase gene family member , leads to decreased neuronal apoptosis and neurodevelopmental abnormalities . ^^^ To determine whether Bcl 10 ( L ) and Caspase 9 interact in an obligate pathway of neuronal apoptosis , bcl x / caspase 9 double homozygous mutants were generated . ^^^ The increased apoptosis of immature neurons observed in Bcl 10 ( L ) deficient embryos was completely prevented by concomitant Caspase 9 deficiency . ^^^ In contrast , bcl 10 ( / ) / caspase 9 ( / ) embryonic mice exhibited an expanded ventricular zone and neuronal malformations identical to that observed in mice lacking only Caspase 9 . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
Cell death is blocked by a dominant negative form of caspase 9 and Bcl 10 ( L ) consistent with a pathway that involves mitochondria . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
Furthermore we observed cleavage of both caspase 9 and caspase 8 after overexpression of p 53 and found that p 53 dependent apoptosis was inhibited by either cellular ( c Flip s , Bcl 10 ( L ) ) or pharmacological inhibitors of caspase 8 or caspase 9 respectively . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
The catalytically active , but not the inactive , forms of hFEM 2 induced caspase dependent apoptosis , which was blocked by Bcl XL or a dominant negative mutant of caspase 9 . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
Finally , examination of other factors , such as bcl 2 , bcl xl , caspase 3 , and caspase 9 , demonstrated significant changes that were correlated with oxLDL treatment and ILK overexpression . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
Bcl 10 ( L ) prevented oxygen deprivation induced cell death by inhibiting the release of cytochrome c and caspase 9 activation . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
EGCG also caused a decrease in the Bcl 2 and Bcl 10 ( L ) proteins , an increase in the Bax protein , and activation of caspase 9 , suggesting that EGCG induces apoptosis via a mitochondrial pathway . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
Targeted gene disruptions of members of the bcl 2 and caspase gene families have demonstrated particularly significant roles for bcl 10 , bax , caspase 9 and caspase 3 in mammalian brain development . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
De novo ceramide regulates the alternative splicing of caspase 9 and Bcl 10 in A 549 lung adenocarcinoma cells . ^^^ Previous studies have demonstrated that several splice variants are derived from both the caspase 9 and Bcl 10 genes in which the Bcl 10 splice variant , Bcl 10 ( L ) and the caspase 9 splice variant , caspase 9b , inhibit apoptosis in contrast to the pro apoptotic splice variants , Bcl 10 ( s ) and caspase 9 . ^^^ In this study , the regulation of the alternative processing of pre mRNA of both caspase 9 and Bcl 10 ( L ) was examined in response to ceramide . ^^^ Treatment of A 549 lung adenocarcinoma cells with cell permeable ceramide , D e C ( 6 ) ceramide , down regulated the levels of Bcl 10 ( L ) and caspase 9b mRNA and immunoreactive protein with a concomitant increase in the mRNA and immunoreactive protein levels of Bcl 10 ( s ) and caspase 9 in a dose and time dependent manner . ^^^ A role for endogenous ceramide in regulating the alternative splicing of caspase 9 and Bcl 10 was demonstrated using the chemotherapeutic agent , gemcitabine . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
Bcl 10 ( L ) protected cells from nitric oxide induced apoptosis during hypoxia by preventing the release of cytochrome c , caspase 9 activation , and by maintaining a mitochondrial membrane potential . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
Rat1a cells exposed to hyperoxia underwent apoptosis characterized by the release of cytochrome c , activation of caspase 9 , and nuclear fragmentation that was prevented by the overexpression of Bcl 10 ( L . ) Murine embryonic fibroblasts from bax ( / ) bak ( / ) mice were resistant to hyperoxia induced cell death . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
The antiapoptotic protein Bcl 10 ( L ) prevented the anoxia induced cell death by inhibiting the release of cytochrome c and caspase 9 activation . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
In contrast , chelator mediated cell death was blocked in cells microinjected with Bcl XL and completely inhibited in cells microinjected with a dominant negative caspase 9 expression vector . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
Furthermore , the increase of p 21 ( Cip1 / Waf1 ) , phosphorylation of Bcl 2 and Bcl 10 ( L ) , activation of caspase 9 and caspase 3 may be the molecular mechanism through which NCTD induces apoptosis . . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
Tumor cells with constitutive activation of CK 2 exhibit a high Bcl 10 ( L ) / tBID ratio and fail to activate caspase 9 or undergo apoptosis in response to Apo2L / TRAIL . ^^^ Conversely , reduction of the Bcl 10 ( L ) / tBID ratio by inhibition of CK 2 renders such cancer cells sensitive to Apo2L / TRAIL induced activation of caspase 9 and apoptosis . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
The apoptosis triggered by H 6 was accompanied by up regulation of Bcl 10 ( S ) , accumulation of cytosolic cytochrome c and activation of caspase cascade ( caspase 9 and 3 ) . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
BCR ligation activated mitochondrial apoptotic pathways including down regulation of Bcl 10 ( L ) , dissipation of mitochondrial transmembrane potential , release of cytochrome c , and activation of caspase 9 . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
Constitutive overexpression of bcl xL in NIH3T3 cells protected the UV induced apoptosis by preventing the loss of mitochondrial membrane potential and the activation of caspase 9 . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
We detected a decrease in the expression of bcl 2 and bcl 10 ( L ) , two antiapoptotic proteins that decrease mitochondrial membrane permeability , an increase in cytochrome c immunoreactivity in the cytosolic fraction , and an activation of caspase 9 in brain regions which show apoptotic neurodegeneration following percussion brain trauma in 7 day old rats . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
Furthermore , it is believed that the apoptosis of osteoclast precursors may be involved in the activation of caspase 9 and that M CSF may promote their survival through Bcl 10 ( L ) induced inhibition of caspase 9 activation . . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
Apaf 1 , Bcl xL , cytochrome c , and caspase 9 form the critical elements for cerebral vascular protection by erythropoietin . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
Apoptotic process of Caki 2 cells was associated with the changes of Bcl 2 , Bcl XL , caspase 9 , caspase 3 , caspase 7 proteins as well as mitochondria transmembrane potential ( DeltaPsim ) loss . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
Screening potential mediators of DN IkappaB and TNF induced apoptosis shows that caspase 3 , caspase 9 , poly ( ADP ribose ) polymerase , and Bax are activated , whereas levels of Bcl XL , cIAP 1 , and TRAF 6 were reduced . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
This review focuses on novel strategies to induce apoptosis in glioma cells by transduction with adenoviral vectors carrying a variety of apoptosis related genes , including Fas ligand , Fas , FADD , caspase 8 , p 53 , p33ING1 , p73alpha , Bax , Apaf 1 , caspase 9 , IkappaBdN , caspase 3 , Bcl 2 , and Bcl 10 ( L ) . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
The overexpression of Bcl xL also prevented the activation of caspase 9 and 3 . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
Bcl xL and caspase 2 also declined significantly ; caspase 9 activity rose . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
Here we show that codelivery of DNA encoding inhibitors of apoptosis ( BCL xL , BCL 2 , XIAP , dominant negative caspase 9 , or dominant negative caspase 8 ) with DNA encoding model antigens prolongs the survival of transduced DCs . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
CONCLUSION : Decreased proapoptotic Bcl 10 ( S ) and increased antiapoptotic Bcl 10 ( L ) , as well as decreased downstream proapoptotic caspase 9 expression , during liver ischemia after treatment with rATG , all favor cell survival . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
Bcl 10 ( L ) expression delays , but does not totally block , the release of mitochondrial cytochrome c ( cyt c ) in these cells in response to TNFalpha induced apoptosis and caspase 9 is processed prior to mitochondrial cyt c release under these circumstances . ^^^ A caspase 9 specific inhibitor was more effective in delaying the progression of apoptosis in the FL5 . 12 Bcl 10 ( L ) cells than was an inhibitor specific to caspase 3 . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
In particular , CD26 / DPPIV presence is associated with increased susceptibility to the mitochondrial pathway of apoptosis , documented by enhanced cleavage of poly ( ADP ribose ) polymerase ( PARP ) , caspase 3 and caspase 9 , Bcl xl , and Apaf 1 , as well as increased expression of death receptor 5 ( DR 5 ) . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
Reduced beta cell apoptosis resulted from elevated Bcl 2 and Bcl 10 ( L ) activity and diminished caspase 9 activity , indicating a novel role for a mitochondrial dependent pathway of beta cell death . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
Indeed , cytochrome c was not released to the cytosol ; Bax and caspase 9 and 3 were not involved ; overexpressed Bcl xL did not block the death ; and the mitochondrial ultrastructure was not changed . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
In addition , ectopic expression of mitochondrial antiapoptotic Bcl 2 , Bcl 10 ( L ) , or inactive caspase 9 short form suppressed DeltaTau 1 toxicity . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
Evidence supporting the involvement of K+ efflux , the apoptosome ( caspase 9 , apoptosis activating factor 1 , APAF 1 , and Bcl xL ) , caspase 3 , c jun kinase , and p 53 in the p75NTR cell death pathway is discussed and regulatory roles for the p75NTR ectodomain and death domain are proposed . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
In addition , the apoptotic process involves activation of caspase 9 , a decrease of Bcl 2 as well as Bcl XL levels , and an increase of Bax levels . . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
The underlying mechanism of action of SAH mediated inhibition of BCL XL ( and / or BCL 2 ) cell survival appears to be due to loss of mitochondrial integrity as reflected in enhanced cytochrome c release leading to the activation of caspase 9 and finally caspase 3 . . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
Anti apoptotic Bcl 2 and Bcl XL , pro apoptotic Bax , caspase 3 and caspase 9 expression and activation were analysed using Western immunoblots and densitometry . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
In contrast , the lack of mitochondrial transmembrane potential transition , release of cytochrome c and absence of caspase 9 and PARP cleavage showed a strong correlation with Bcl xL expression . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
Apoptosis was associated with mitochondrial membrane depolarization and activation of caspase 9 and 3 but proceeded despite over expression of Bcl XL a known correlate of relapsed and chemorefractory myeloma . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
Furthermore , we showed that release of mitochondrial cytochrome c , cleavage of caspase 9 and PARP during apoptosis in T . vaginalis treated RAW264 . 7 cells were considerably diminished by transfection with overexpressed Bcl 10 ( L ) , and overexpressed Bcl 10 ( L ) could inhibit T . vaginalis induced apoptosis in RAW264 . 7 cells . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
When grown in coculture with endothelial cells and exposed to LPS in coculture but harvested independently , pericytes showed decreased levels of p 11 and p 17 and increased levels of Bcl xL , an antiapoptotic protein that protects the integrity of mitochondria , and prevents cytochrome c release and subsequent caspase 9 activation . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
Inhibition of caspase 9 after combination treatment blunted neither JNK1 / 2 / 3 activation nor the enhanced expression of BAD and BAX , but did block caspase 3 cleavage , reduced expression of BCL XL and inhibition of ERK1 / 2 activity . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
In addition , release of cytochrome c from mitochondria , down expression of Bcl 2 and Bcl 10 ( L ) , up regulation of Bax , and caspase 9 activities were observed in SM treated A 549 cells . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
Knockdown of Bcl xL and administration of TRAIL significantly synergized in dissipation of mitochondrial membrane potential , release of cytochrome c , activation of caspase 9 and 3 and , consequently , apoptotic cell death . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
Taken together , it is suggested that caseamembrin C induced apoptosis is predominantly through the activation of intrinsic apoptosis pathways by causing the down regulation of Bcl 2 and Bcl xL expression , up regulation of Mcl 1S protein and activation of caspase 9 and caspase 3 . . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
Interestingly , we find that single inhibitors of caspase activation , such as BCL XL or dominant negative mutants of FADD and caspase 9 , protect cancer cells against antigen specific CTL in vitro . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
The antiapoptotic proteins , Bcl 2 and Bcl xl , were downregulated by GSP , whereas the expression of the pro apoptotic protein , Bax , and the levels of cytochrome c release , Apaf 1 , caspase 9 , and cleaved caspase 3 ( p 19 and p 17 ) were markedly increased in JB 6 C141 cells . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
Attenuating erbB signals in cultured neonatal rat cardiomyocytes by the erbB 2 antagonist tyrphostin AG 825 , by the erbB1 / 4 antagonist AG 1478 or by antisense induced lowering of erbB 2 receptors resulted in an augmented Bcl xS / Bcl xL ratio , mitochondrial release of cytochrome c , activation of caspase 9 and caspase 3 , and nucleosome sized DNA fragmentation . ^^^ A similar DNA fragmentation and caspase 3 activation was induced by TNF alpha , but without Bcl xS / Bcl xL increase , cytochrome c release or caspase 9 activation . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
Immunoblot analysis of Bax , Bcl 2 , Bcl xL , and caspase 9 were performed . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
To characterize the mechanisms of apoptosis induction by proteasome inhibitors , we examined levels of Bcl 2 protein family members ( Bik / NBK , Bax , Bak , Bcl 2 , and Bcl XL ) , release of cytochrome c , and activation of caspase 9 and 3 in human colon cancer cell lines DLD 1 , LOVO , SW 620 , and HCT 116 ; human lung cancer cell line H 1299 ; and human ovarian cancer cell line SKOV 3 after they were treated with bortezomib . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
Here we used embryonic fibroblasts derived from mice deficient in the multidomain proapoptotic members of the Bcl 2 family ( Bax and Bak ) and the apoptotic components of the apoptosome ( Apaf 1 and caspase 9 ) to unravel the cascade of events by which Bcl 10 ( S ) promotes apoptosis . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
Both caused apoptosis by increasing the protein expression of Bax and Bcl xs while decreasing Bcl 2 and Bcl 10 ( L ) , releasing apoptogenic cytochrome c , and augmenting the activity of caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
Combining the Bcl 10 ( L ) siRNA with TRAIL protein treatment resulted in an increase in the percentage of apoptotic cells and increased cleavage of caspase 8 , caspase 9 , caspase 3 and PARP . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
In this study , we show that UPR gene expression is induced in cells treated with ER stress agents in the presence or absence of murine caspase 12 or human caspase 4 expression and in cells that overexpress Bcl 10 ( L ) or a dominant negative caspase 9 . ^^^ We further demonstrate that ER stress induced apoptosis is a caspase dependent process that does not require the expression of caspase 12 or caspase 4 but can be inhibited by overexpression of Bcl 10 ( L ) or a dominant negative caspase 9 . ^^^ Additionally , treatment of human and murine cells with ER stress agents led to the cleavage of the caspase 4 fluorogenic substrate , LEVD 7 amino 4 trifluoromethylcoumarin , in the presence or absence of caspase 12 or caspase 4 expression , whereas Bcl 10 ( L ) or a dominant negative caspase 9 overexpression inhibited LEVD 7 amino 4 trifluoromethylcoumarin cleavage . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
Proteins for Western blot analysis included Fas associated death domain ( FADD ) and caspase 8 for extrinsic pathway , as well as Bcl 2 , Bcl XL , Bax , Bad , Bid , Akt , p Akt , and caspase 9 for intrinsic pathway . ^^^ Levels of FADD , Bax , Bad , and Bid were substantially increased in the TA induced myopathy group , whereas Bcl 2 , Bcl XL , Akt , p Akt , and caspase 9 did not change between control and myopathy groups . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
We evaluated the levels of Bax , Bcl xL , Bcl 2 and cytochrome c expression by Western blot analysis , and caspase 9 and 3 activities were determined in a colorimetric assay . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
ZD 1839 inhibited the phosphorylation of Akt , and enhanced TRAIL induced apoptosis via activation of caspase 3 and caspase 9 , and inactivation of Bcl xL . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
TRAIL induced caspase 8 activation , Bid processing , drop of DeltaPsi ( m ) , and poly ADP ribose polymerase ( PARP ) cleavage but not in caspase 9 activation , and these events were inhibited in HER2 / PI3K / Akt suppressed BT 474 cells , which on the other hand exhibited downregulation of Bcl xL and increased response to mitomycin C . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
Ellipticine increased the expression of Bax , but decreased the level of Bcl 2 , Bcl XL and 10 linked inhibitor of apoptosis protein ( XIAP ) , and subsequently triggered the mitochondrial apoptotic pathway ( release of cytochrome c , and activation of caspase 9 and 3 ) . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
Lastly , we show that NF kappaB inhibits c Myc induced activation of caspase 9 and caspase 3 through up regulation of the antiapoptotic target genes Bcl 10 ( L ) and 10 linked inhibitor of apoptosis ( XIAP ) . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
Resistance of Bcl xL overexpressing cells to taxanes correlated with the failure to activate caspase 9 . 2 Methoxyantimycin A 3 , a chemical inhibitor of Bcl xL , sensitized Bcl xL overexpressing cells to paclitaxel and docetaxel , which suggests the drugs that inhibit Bcl xL activity can be used as sensitizers to taxanes . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
The decrease of Bcl 2 and Bcl XL along with this oxidative stress caused release of mitochondrial cytochrome c into the cytosol and subsequent induction of pro caspase 9 processing . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
Apoptosis by I3C involves downregulation antiapoptotic gene products , including Bcl 2 , Bcl xL , survivin , inhibitor of apoptosis protein ( IAP ) , 10 chromosome linked IAP ( XIAP ) , and Fas associated death domain protein like interleukin 1 beta converting enzyme inhibitory protein ( FLIP ) ; upregulation of proapoptotic protein Bax ; release of micochondrial cytochrome C ; and activation of caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
Similarly , immunoreactivity for the apoptotic signals Fas , Fas ligand , Bax , Bcl 10 , caspase 8 , caspase 9 and caspase 3 was absent from the NBM of AD and control brains . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NaBt treatment results in a marked down regulation of Bcl xL expression , mitochondrial membrane depolarization , cytochrome c release from mitochondria , activation of caspase 9 and 3 and apoptosis induction . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
We found that the intrinsic pathway is activated early on during anesthesia exposure ( within two hours ) , as measured by the down regulation of bcl 10 ( L ) , up regulation of cytochrome c and the activation of caspase 9 in 7 day old rats ( the peak of synaptogenesis ) , but remains inactivated in 14 day old rats ( the end of synaptogenesis ) . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
The number of apoptotic cells in lung sections was determined by a TUNEL method . mRNAs for Fas , FasL and caspase 8 , and for Bad , Bax , Bcl w , Bcl xL and caspase 9 , for the FasL and the mitochondrial cytochrome c pathways of apoptosis , respectively , and mRNA for the effector caspase 3 were quantified in lung tissues by RT PCR . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
The increased levels of active caspase 9 correlated with Bax / Bcl 2 and Bcl 10 ( L ) expression suggesting that the apoptotic mitochondrion dependent pathway is involved in decidual regression during pregnancy progression . . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
Expression of Smad 7 and Bcl 10 ( L ) , but not viral FLIP , was shown to prevent TGF beta induced apoptosis , indicating an exclusive requirement of the activation of Smad signaling pathway and mitochondrial dysfunction followed by activation of caspase 9 . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
In addition , chalcone also triggered the mitochondrial apoptotic signaling by increasing the amount of Bax and Bak and reducing the level of Bcl 2 and Bcl 10 ( L ) , and subsequently activated caspase 9 in MCF 7 and MDA MB 231 cells . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
Characterization of cell clones stably transfected with short form caspase 9 : apoptotic resistance and Bcl XL expression . ^^^ In the cytosol , they expressed dominant negative caspase 9 , and at the mitochondria they up regulated Bcl XL . . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
Ad COX 1 / PGIS transfection was found to reduce the adriamycin stimulated activities of caspase 3 and caspase 9 , inhibit adriamycin induced release of cytochrome c , elevate the expression of Bcl 10 ( L ) , and suppress the activation and translocation of nuclear factor kappaB ( NF kappaB ) in adriamycin treated renal tubular cells . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
The down regulation of the cyclin A , Bcl 2 , and Bcl 10 ( L ) expression with the simultaneous up regulation of the p 21 and Bax expression , and caspase 9 activation was observed in ECSC after bufalin treatment . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
Moreover , over expression of Bcl 2 or Bcl xL and expression of dominant negative caspase 9 partially reduced Ukrain induced apoptosis pointing to Bcl 2 controlled mitochondrial signalling events . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
Apoptosis induced by each TM was associated with a significant ( approximately 400 % ) increase in caspase 8 activity , but no change in caspase 9 activity , and Western analyses revealed a marked up regulation of Fas ( approximately 500 % ) and FADD ( approximately 300 % ) with no change in expression of Bax , Bcl 2 , or Bcl xL . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
Both PUNI and EA provoked the same effects on Caco 2 cells : down regulation of cyclins A and B 1 and upregulation of cyclin E , cell cycle arrest in S phase , induction of apoptosis via intrinsic pathway ( FAS independent , caspase 8 independent ) through bcl XL down regulation with mitochondrial release of cytochrome c into the cytosol , activation of initiator caspase 9 and effector caspase 3 . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
Examples of prominent CARD proteins are caspase 9 and Apaf 1 , which are involved in the intrinsic death pathway ; BCL 10 and CARD 11 , which mediate antigen receptor induced NF kappaB activation ; and receptor interacting protein ( RIP ) like interacting caspase like apoptosis regulatory protein kinase ( RICK ) and the nucleotide binding oligomerization domain ( NOD ) proteins , which induce NF kappaB activation in response to intracellular bacterial peptidoglycan . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
Furthermore , PAF inhibited etoposide induced increases in caspase 3 , caspase 8 , and caspase 9 activities , as well as cell death . p50 / p65 heterodimer increased the mRNA expression of Bcl 2 and Bcl xL and decreased etoposide induced caspase activities and cell death . ^^^
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
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Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA
Interacting proteins: P55211 and Q07817 Pubmed SVM Score :0.0
NA