| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| JNK phosphorylates BAD at threonine 201 , thereby inhibiting BAD association with the antiapoptotic molecule BCL 10 ( L ) . ^^^ |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| Moreover , Bcl xL rescued WEHI 231 cells from apoptosis induced by the JNK inhibitor . ^^^ |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| We examined the role of Bcl 2 and Bcl 10 ( L ) in the regulation of cytosolic Ca ( 2+ ) , nitric oxide production ( NO ) , c Jun NH ( 2 ) terminal kinase ( JNK ) activation , and apoptosis in Jurkat T cells . ^^^ Overexpression of Bcl 2 or Bcl 10 ( L ) inhibited TG induced loss in mitochondrial membrane potential , release of cytochrome c , and activation of caspase 3 and JNK . ^^^ |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| Because microtubule inhibitors activate JNK , we sought to determine whether JNK was responsible for Bcl 2 / Bcl 10 ( L ) phosphorylation in KB 3 cells treated with vinblastine . ^^^ Stable expression of the JNK scaffold protein JIP 1 blocked vinblastine induced phosphorylation of c Jun and ATF 2 , but did not affect Bcl 2 / Bcl 10 ( L ) phosphorylation , confirming a bifurcation in JNK signaling involving both nuclear and non nuclear substrates . ^^^ These results provide evidence for a direct role of the JNK pathway in apoptotic regulation through Bcl 2 / Bcl 10 ( L ) phosphorylation . . ^^^ |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| CSF 1 maintained NF kappaB activation and increased the expression of bcl 2 and bcl 10 ( L ) mRNA , but had no effect on JNK activation . ^^^ In contrast , OPGL enhanced both NF kappaB and JNK kinase activation and increased the expression of c src , but not bcl 2 and bcl 10 ( L ) mRNA . ^^^ |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| The activation of JNK and MAPK kinase , which regulate these transcription factors , was reduced in Bcl 10 ( L ) transfected cells . ^^^ Overall , our results demonstrate that Bcl 10 ( L ) inhibits TNF signaling at an early step common to induction of activation of apoptosis , NF kappaB , AP 1 , MAPK , and JNK . . ^^^ |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| The p 54 isoform of c jun N terminal kinase stress activated kinase ( JNK SAPK ) coimmunoprecipitated with Akt from me 5 macrophages , and treatment of me 5 cells with the specific phosphatidylinositol 3 kinase inhibitor LY 294002 decreased cell survival , Akt and JNK kinase activities , ets 2 phosphorylation , and Bcl 10 mRNA expression . ^^^ |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| Synergistic potentiation of STI 571 mediated lethality by PD 184352 was associated with multiple perturbations in signaling and apoptotic regulatory pathways , including caspase dependent down regulation of Bcr Abl and Bcl 2 ; caspase independent down regulation of Bcl 10 ( L ) and Mcl 1 ; activation of JNK , p 38 MAPK , and p 34 ( cdc 2 ) ; and diminished phosphorylation of Stat 5 and CREB . ^^^ |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| Expression of Akt did not alter the levels of Bax , Bcl 2 , Bcl 10 ( L ) , or phosphorylated JNK under the conditions used , suggesting that there were alternative mechanisms for Akt in the suppression of Bax translocation . ^^^ |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| Here , we show that hTid 1 represses NF kappaB activity induced by Tax as well as other activators such as tumor necrosis factor alpha ( TNFalpha ) and Bcl 10 . hTid 1 specifically suppresses serine phosphorylation of IkappaBalpha by activated IkappaB kinase beta ( IKKbeta ) , but the activities of other serine kinases including p 38 , ERK 2 , and JNK 1 are not affected . ^^^ |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| A CARMA 1 mutant , defective for Bcl 10 binding , had a dominant negative ( DN ) effect on TCR induced NF kappa B activation and IL 2 production and on the c Jun NH ( 2 ) terminal kinase ( Jnk ) pathway when the TCR was coengaged with CD 28 . ^^^ |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| Although the c Jun N terminal kinase ( JNK ) has been proposed to mediate the phosphorylation of Bcl 2 / Bcl 10 ( L ) the mechanisms linking the modification of these proteins and the release of cytochrome c remain to be elucidated . ^^^ Taken together , JNK dependent phosphorylation of mitochondrial proteins including , but not limited to , Bcl 2 / Bcl 10 ( L ) may represent a potential of the modulation of mitochondrial function during apoptosis . . ^^^ |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| Malt 1 operates downstream of Bcl 10 , controls the catalytic activity of the canonical IKK complex , and regulates the signaling of Jnk and p 38 MAP kinases . ^^^ |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| We found a specific increase in phosphorylation of c Jun N terminal kinase ( JNK ) accompanied by neurite extension in MN9D / Bcl 2 but not in MN9D / Bcl 10 ( L ) cells . ^^^ Consequently , neurite extension in MN9D / Bcl 2 but not in MN9D / Bcl 10 ( L ) cells was suppressed by treatment with SP 600125 , a specific inhibitor of JNK . ^^^ |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| Since CD3 / CD28 induced activation of JNK is not affected by the decline of Bcl 10 , degradation of Bcl 10 selectively terminates IKK / NF kappa B signaling in response to TCR stimulation . ^^^ |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| To understand which JNK mediated pathway may be involved , a number of JNK target proteins were examined , including the transcription factor , c Jun , and the apoptotic regulatory proteins Bcl 10 ( L ) and Bim . ^^^ |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| Western blot analysis was used to evaluate the level of ICAD , ERK / p ERK , JNK / p JNK , and Bcl 10 ( L ) / Bax expression . ^^^ |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| Induction of Bcl 10 activity caused rapid activation of nuclear factor kappaB ( NF kappaB ) and c Jun N terminal kinase ( JNK ) , but not activation of extracellular signal regulated kinase ( ERK ) or p 38 mitogen activated protein ( MAP ) kinases . ^^^ |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| JNK inhibition resulted in decreased expression of CSF 1R ( c fms ) and Bcl 10 ( L ) mRNA in mature macrophages and repressed CSF 1 dependent differentiation of bone marrow cells to macrophages . ^^^ |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| For instance , the cell signaling pathways inhibited by curcumin alone include NF kappaB , AP 1 , STAT 3 , Akt , Bcl 2 , Bcl 10 ( L ) , caspases , PARP , IKK , EGFR , HER 2 , JNK , MAPK , COX 2 , and 5 LOX . ^^^ |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| In addition , Bcl 2 and Bcl xL suppressed PEITC induced apoptosis , but failed to protect cells from death induced by overexpression of activated JNK 1 . ^^^ These results suggest that Bcl 2 and Bcl xL are upstream of JNK . ^^^ |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| Here we demonstrate that methylmethane sulfonate ( MMS ) induced activation of JNK is inhibited by overexpression of the anti apoptotic protein Bcl xL , but not by caspase inhibitors CrmA and p 35 . ^^^ By contrast , UV induced JNK activity is insensitive to Bcl xL . ^^^ The results demonstrate that treatment with MMS is associated with an increase in tyrosine phosphorylation of related adhesion focal tyrosine kinase ( RAFTK ) / proline rich tyrosine kinase 2 ( PYK 2 ) , an upstream effector of JNK and that this phosphorylation is inhibited by overexpression of Bcl xL . ^^^ Hence , treatment of Bcl xL cells with sodium vanadate , a tyrosine phosphatase inhibitor , restores MMS induced activation of RAFTK and JNK . ^^^ These findings indicate that RAFTK dependent induction of JNK in response to MMS is sensitive to Bcl xL , but not to CrmA and p 35 , by a mechanism that inhibits tyrosine phosphorylation and thereby activation of RAFTK . ^^^ |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| Moreover , the caspase inhibitor zVAD fluoromethylketone as well as expression of bcl 2 or bcl xL inhibited cortical neuron apoptosis induced by arsenite or by constitutive activation of JNK or p 38 . ^^^ |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| As targets for participation in apoptosis , Bcl 2 and Bcl xl were phosphorylated in response to JNK activation by taxol or UV ; this was prevented by E 2 . ^^^ |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| The survival genes Bcl 2 , Bcl XL , and survivin act independently and downstream of ERK and JNK to decrease the survival of TNF alpha treated RT 101 cells . ^^^ |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| Sequential analyses were made following ethanol exposure on these two postnatal days , with assessments of NTFs nerve growth factor ( NGF ) , brain derived neurotrophic factor ( BDNF ) , neurotrophin 3 ( NT 3 ) , and neurotrophin 4 ( NT 4 ) ; apoptosis related proteins Bcl 2 , Bcl xl , Bax , Akt and c jun N terminal kinase ( JNK ) ; antioxidants superoxide dismutase , glutathione reductase and catalase ; and ROS . ^^^ |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| Further studies with the inhibitor of Jun kinase ( JNK ) and phosphorylation null mutant of Bcl xL reveal the augmentative role of JNK mediated Bcl xL phosphorylation in apoptosis of prostate cancer cells . ^^^ |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| These data suggest that P regulates apoptosis or survival through augmentation of JNK signaling and altered TNFR 1 expression , whereas E mainly affects the expression of BCL xL , TNFR 1 , and ERalpha . . ^^^ |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| These events were associated with Bcl 2 cleavage , Bax , Bak , and Bad accumulation , mitochondrial translocation of Bax , abrogation of Mcl 1 , Bcl xL , and XIAP upregulation , and a marked induction of JNK and p 53 . ^^^ |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| Ectopic expression of Bcl 2 or Bcl xL but not dominant negative caspase 8 blocked UCN 01 / L744832 mediated mitochondrial dysfunction and apoptosis but did not prevent activation of p 34 ( cdc 2 ) and JNK or inactivation of MEK / ERK and Akt . ^^^ |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| Internally , validated inhibitors of JNK , ERK , p 38 ( MAPK ) , or CDK 1 failed to inhibit vinblastine induced phosphorylation of Bcl xL or Bcl 2 . ^^^ In vitro , Bcl xL and Bcl 2 were poor substrates relative to c Jun and ATF 2 for active recombinant JNK 1 . ^^^ |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| The expression of Bcl XL , Bcl 2 , and XIAP significantly decreased , and activation of JNK was prolonged for up to 6 h in infected cells treated with TNF alpha . ^^^ The expression of Bcl XL , Bcl 2 and XIAP and activation of JNK were affected by ad IkappaB SR transduction , implying a role in the NF kappaB regulated cell survival signaling in human chondrocytes . . ^^^ |
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| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| In contrast , a gradual and persistent increase in p 38 and JNK MAPKs as well as in caspase 3 and the Bax to Bcl xl ratio may contribute in the initiation of apoptosis and progression of heart failure . ^^^ |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| RESULTS : SP 600125 at 10 microM drastically inhibited JNK phosphorylation but had little effect on CD 40 mediated p 38 phosphorylation and expression of the NF kappaB dependent genes c Myc and bcl xL . ^^^ |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| The p65 / RelA subunit of NFkappaB may influence cell death , in part by activation of NFkappaB anti apoptotic target genes including 10 linked inhibitor of apoptosis ( XIAP ) , A 20 , bcl xL and inhibition of sustained activation of c Jun N terminal kinase ( JNK ) . ^^^ |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Our results indicated that combined treatment led to an increased apoptotic cell death in U 937 cells , which is correlated with the phosphorylation of the 5 Jun sarcoma virus 17 oncogene homolog ( c JUN ) NH ( 2 ) terminal kinase protein ( JNK ) , the activation of caspases , the increase in B cell leukemia / lymphoma 2 ( Bcl 2 ) associated 10 protein ( Bax ) , the decrease in Bcl xL protein ( Bcl XL ) levels , the loss of mitochondria membrane potential and the release of cytochrome c . ^^^ |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| In persistently infected cells at 50h . p . i . , PI3K / Akt , JNK , p 38 MAPK and Bcl 2 were phosphorylated and the protein levels of Bcl 2 and Bcl xL were increased . ^^^ These results indicated that at least four proteins , Akt , JNK , Bcl 2 and Bcl xL , are necessary for survival of persistently SARS CoV infected cells . . ^^^ |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|