Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.67391947
We report here on the high detection rate of the Bcl 10 protein found in 86 % of Hodgkin ' s disease samples and on the significance regarding its complex role among the Bcl 2 family of proteins : Bcl 10 is known to heterodimerize with Bcl 2 ( an anti apoptosis protein ) and with Bax , a potent inducer of cell death . 0.67391947^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.62638191
In an acquired immune deficiency syndrome related neoplasm , Kaposi ' s sarcoma , the spindle shaped tumor cells also overexpressed Bcl xL compared with Bcl 2 . 0.62638191^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Identification of immunosuppressant induced apoptosis in a murine B cell line and its prevention by bcl 10 but not bcl 2 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We have recently cloned a member of the bcl 2 family , bcl 10 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The alternatively spliced bcl 10 gene , bcl Xs , which interferes with the action of bcl 2 , was not expressed . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
HgCl 2 also induced members of the bcl family , bcl 2 and bclx , genes that protect against apoptosis and oxidant injury . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
A physiologic role for Bcl 2 and Bcl 10 in neuron survival has been shown . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In Rat1a fibroblasts , activated Akt did not alter Bcl 2 or Bcl 10 ( L ) expression but inhibited Ced3 / ICE like activity . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The human Bcl 2 family member Bak induces apoptosis in mammalian cells which is counteracted by the Bcl 10 ( L ) protein . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In addition , activated K ras up regulates bcl 2 but has no effect on bax or bcl 10 expression . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The Bcl 2 family members analyzed were Bcl 2 , Bcl 10 , Bax , Bad , Bak , A 1 , and Mcl 1 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
None of the cytokines tested caused a change in the levels of expression of Bcl 2 , Bax , Bcl 10 , or Bak proteins . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Another bcl 2 related gene , bcl 10 , was previously reported to generate two transcripts in human cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
CD40L up regulated bcl 10 ( L ) mRNA but not bcl 2 in CLL cells within 3 6 h in culture . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Expression of bcl 2 family members ( bax , bcl 10 ) was modulated by fotemustine , etoposide and cisplatin . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In contrast , HGF did not affect the expression of the apoptosis suppressors Bcl 2 and Bcl 10 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Also , Bcl 2 , Bcl 10 , Bak , Bad and p 53 were increased in AD brains . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In contrast , giant cells show only weak positivity for bcl 2 and moderate positivity for bcl 10 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Here , we show by Western blotting that human neutrophils do not express Bcl 2 or Bcl 10 but constitutively express Bax . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Finally , TS1alphabeta survival is independent of Bcl 2 , Bcl 10 , or Bax . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Both pathways were fully blocked by Bcl 2 or Bcl 10 ( L ) . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Quiescent memory B cells in human peripheral blood co express bcl 2 and bcl 10 ( L ) anti apoptotic proteins at high levels . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Cytokines also mediated an NO dependent , sustained increase in myocyte expression of the Bcl 2 homologs Bak and Bcl 10 ( L ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 10 and Bcl 2 immunoreactivity in postnatal mouse barrel fields . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Mutation of threonine 169 did not affect the binding of Bax to Bax , Bcl 2 , or Bcl 10 ( L ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Interestingly , Bcl 2 , Mcl 1 and Bcl 10 ( L ) cumulative expressions were inversely correlated with apoptotic response . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 or Bcl 10 ( L ) had no significant effect on CDK 4 kinase activity in both cell lines . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Only in type 2 cells can apoptosis be blocked by overexpressed Bcl 2 or Bcl 10 ( L ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 10 ( L ) , a member of the Bcl 2 family , inhibits many pathways of apoptosis when overexpressed in the cell cytosol . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
TGF beta dose dependently increased the expression of Bcl 2 and Bad and decreased the expression of Bcl 10 ( L ) in U 937 cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 , Bcl 10 , and p 53 were not affected by the addition of IL 6 and / or IFN alpha . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Contrary to expected observations , no changes in Bcl 2 and Bcl 10 ( L ) protein levels were observed . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
However , it is unknown whether Bcl 2 or Bcl 10 ( L ) have to homodimerize to protect cells from apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Expression of prosurvival Bcl 10 ( L ) or Bcl 2 proteins blocked the induction of Hrk . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In contrast , Bcl 2 , Bcl 10 ( L ) , and Bax levels were not affected by bisindolylmaleimide . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Opposing actions of STAT 1 and STAT 3 on the Bcl 2 and Bcl 10 promoters . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
When coexpressed with Bcl 2 or Bcl 10 ( L ) , the apoptotic effect of HIV 1 Vpr became markedly attenuated . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 10 ( L ) , an antiapoptotic Bcl 2 family member , is postulated to function at multiple stages in the cell death pathway . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
First , western blot analysis shows that Bcl 10 ( L ) rather than Bcl 2 is overexpressed in primary adenocarcinoma of colon . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We found that the proviability protein Bcl 10 ( L ) , but not Bcl 2 , was induced by both p 210 ( Bcr / Abl ) and STAT 5 1 * 6 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We conclude that TGF beta 1 induced cell death is independent of p 53 and inhibited by Bcl 2 , with no effect on Bcl 10 ( L ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Apoptosis was coupled with decreased expression of bcl 10 ( L ) and bcl 2 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In addition , apoptosis inhibitors Bcl 2 and Bcl 10 ( L ) were highly expressed in KMS 12 BM cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
After PDT , expression of Bcl 2 , Bcl 10 ( L ) , Bax , and Bak was also examined in cell lysates by Western blot analysis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Messenger RNA expression levels of c myc , p 21 , bax , bcl 2 , and bcl 10 were not changed by the treatment with troglitazone . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Levels of Bcl 2 were elevated in 3 of 10 cell lines , and only marginal differences were observed for Bcl 10 ( L ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Apo 2L induced apoptosis was significantly inhibited in HL 60 cells that overexpressed Bcl 2 or Bcl 10 ( L ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
These findings are correlated with modulations in bax , bcl 2 , bcl 10 ( L ) and p 21 protein levels . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In Hashimoto ' s thyroiditis an impairment of Bcl 2 and Bcl 10 anitapoptotic genes on thyrocytes has also been detected . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Expression of Bcl 2 , Bcl 10 , and Bax proteins in cultured fibroblasts was studied by Western blotting . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Transfection with Bcl 10 ( L ) or Bcl 2 led to protection against SAL mediated PC 12 cell death . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Both treatments led to rapid apoptosis associated with downregulation of Bcl 10 ( L ) and Bcl 2 , two antiapoptotic proteins . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Western blot analyses showed up regulation of Bcl 2 but not of Bcl 10 ( L ) by 24 h after the transfer of E2F 1 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In both B and T lymphocytes , treatment of the cells with VA Qu FrF was associated with decreased levels of Bcl 2 and Bcl 10 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The expression of other members of the Bcl 2 family such as Bax , Bcl 10 ( L ) and Bak were not affected . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Overexpression of Bcl 2 or Bcl 10 ( L ) inhibits TRAIL induced DeltaPsi ( m ) and apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In contrast , fumonisin B ( 1 ) had no effect on expression of bcl 2 family genes ( bax , bcl 2 , and bcl 10 ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
No relationship was found between AI and labeling indices of Bcl 2 , Bcl 10 , Bax , p 53 , APO . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In the mammary gland Bcl 10 is the most abundant cell survival factor from the Bcl 2 family . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 10 , a member of the Bcl 2 family , is known to act as a regulator of apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Also , we have measured the levels of Bcl 2 , Bcl 10 , and Bax in 20 cases of T ALL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The regulation of apoptosis by Bcl 2 , bcl 10 ( L ) , Bcl 2alpha and Bax in chronic liver disease ] . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
However , BALF 1 failed to inhibit the cellular BCL 2 family member , BCL 10 ( L ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We observed no detectable changes in the steady state levels of Bcl 2 , Bcl 10 ( L ) , and Bax . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 , Bcl 10 ( L ) , Bax and p 53 protein expression was revealed by Western blotting . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Similarly , levels of antiapoptotic proteins Bcl 2 and Bcl 10 ( L ) in mitochondrial fraction were decreased . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
With YCU N 861 cells , ATRA also caused a decrease in Bcl 2 and Bcl 10 ( L ) and an increase in Bax . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 10 ( L ) is an antiapoptotic member of the Bcl 2 family and is universally expressed in human melanoma . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The expression of Bax , Bcl 2 , Bak , and Bcl 10 ( L ) was analyzed by immunoblotting . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The effect may involve Bcl 2 but not Bcl 10 ( L ) expression . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The levels of the antiapoptotic Bcl 2 and Bcl 10 ( L ) proteins were also inhibited . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We observed no detectable change in the steady state levels of Bax , Bcl 2 , and Bcl 10 ( L ) following raloxifene treatment . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bim ( L ) , although unable to activate Bax , can directly inhibit Bcl 2 or Bcl 10 ( L ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Parthenolide did not alter the expression of Bcl 2 or Bcl 10 ( L ) proteins during apoptosis in hepatoma cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
On the other hand , the expression of bcl 2 and bcl 10 ( L ) mRNA was enhanced in AT2KO mice but attenuated in AT1aKO mice . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Corticosterone differentially regulates bax , bcl 2 and bcl 10 mRNA levels in the rat hippocampus . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
These proteins include the death antagonists Bcl 2 and Bcl 10 ( L ) , and death agonists Bax and Bad . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 and Bcl 10 ( L ) are representative anti apoptosis proteins reported to be capable of suppressing Fas mediated apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Inhibiting NF kappa B signaling by expressing 1 kappa B alpha M significantly reduced expression of Bcl 10 ( L ) and Bcl 2 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 and Bcl 10 ( L ) ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Endothelial cells incubated with IL 8 had higher levels of Bcl 10 ( L ) : Bcl 10 ( S ) and Bcl 2 : Bax ratios . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Furthermore , antiapoptotic proteins Bcl 2 and Bcl 10 were expressed more consistently in CD 34 ( + ) cells than in total MNC . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
All cell lines express high levels of cyclin E , c Myc , Bcl 2 , Bax , Bcl 10 ( L ) , and Mcl 1 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 and Bcl 10 ( L ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
METHODS : We performed Northern blot analysis for bax , bcl 10 ( L ) and bcl 2 at both temperatures . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 10 ( L ) is a pro survival member of the Bcl 2 family that plays an important role in apoptosis regulation . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Immunoprecipitation studies revealed that Nbk interacts with Bcl 10 ( L ) and Bcl 2 but not with Bax . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Treatment with RAs caused the level of Bcl 10 protein decreased , while the levels of Bcl 2 and Bcl xS remained unchanged . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The latter include Bcl 2 , Bcl 10 ( L ) , Mcl 1 , NF ( K ) B , survivin , livin , and ML IAP . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Furthermore , overexpression of Bcl 2 or Bcl 10 ( L ) also inhibits RRM induced apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
While Bcl 2 , Bcl 10 ( L , ) , and Bax were not affected , Mcl 1 was induced by IL 6 in human esophageal carcinoma cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The expression of Bcl 2 and Bcl 10 ( L ) , two anti apoptotic proteins , decreased at 24 h after hypoxia . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The overexpression of Bcl 10 ( L ) or Bcl 2 strongly inhibited calicheamicin induced apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Fibrotic liver also showed downregulation of Bcl 2 and Bcl 10 ( L ) expression and upregulation of Bad expression . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
BNIP3L protein can interact with antiapoptotic proteins , such as Bcl 2 , Bcl 10 ( L ) , E1B19K , which promotes apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 10 ( L ) overexpression also rescues this maturation induced Bcl 2 expression . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In parallel , p 53 can release pro apoptotic Bcl 2 proteins sequestered by Bcl 10 ( L ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
It was preceded by a decrease of anti apoptotic Bcl 2 and BclX ( L ) gene transcripts . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Furthermore , pro apoptotic Bax was overexpressed while anti apoptotic Bcl 2 and Bcl 10 ( L ) were suppressed . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 , Bcl 10 ( L ) , PKC alpha , PKC beta , and PKC delta were detected by Western blotting . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
They reduced the expression of Bax and Bcl 2 proteins , but not Bcl 10 ( L ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 10 is a member of the Bcl 2 family of proteins that are key regulators of apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
A modest increase in survival , not attributable to Bcl 2 or Bcl 10 ( L ) , was also observed with IL 10 treatment . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bak expression in S . pombe is lethal and this lethality is rescued by co expression of bcl 2 or bcl 10 ( L ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Triptolide also decreased Mcl 1 but not Bcl 2 and Bcl 10 ( L ) levels . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
PUMA interacts with anti apoptotic Bcl 2 and Bcl 10 ( L ) and is dependent on Bax to induce apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
LBH 589 down regulated Bcl 2 and particularly Bcl 10 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The Bcl 2 homolog , Bak , promotes apoptosis and binds anti apoptotic family members including Bcl 2 and Bcl xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl xs is a dominant negative repressor of Bcl 2 and Bcl xL , both of which inhibit apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
No marked difference with regard to bcl 2 and bcl xL expression was observed between normal breast epithelium and cancer tissue . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Additionally , like Yama and LAP 3 , Mch 2 functions downstream of the death inhibitors Bcl 2 , Bcl xL , and CrmA . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Here we describe the crystal and solution structures of a Bcl 2 family member , Bcl xL ( ref . 2 ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Like Bcl 2 , the related protein Bcl xL but not Bcl xS was able to suppress kB dependent transcription . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The expression level of bcl 2 , bcl xL , Ich 1L remains unchanged in treated and untreated cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Regulation of lymphoid apoptosis by Bcl 2 and Bcl XL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Protein levels of Bcl 2 and Bcl xL did not significantly vary as a function of growth factor stimulation . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl xL , an antiapoptotic member of the Bcl 2 family , inhibits programmed cell death in a broad variety of cell types . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The apoptosis inhibitors Bcl 2 or Bcl xL prevent the efflux of cytochrome c from mitochondria . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In addition , anti apoptotic members of the Bcl 2 family ( Bcl xL and Bcl 2 ) were not correlated with apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The Bcl 2 family member Bcl xL has often been correlated with apoptosis resistance . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl xL , but not bcl 2 and bax mRNA , was highly inducible within 3 h after stimulation . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
This process is blocked by the anti apoptotic proteins Bcl 2 and Bcl xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The function of BAX is countered by BCL 2 and BCL XL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Cellular protein BNIP 3 ( previously NIP 3 ) interacts with E1B 19K , BCL 2 , BCL xL , and EBV BHRF 1 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
There was no statistically significant change in the expression of Bax , Bcl xl , Bcl 2 , or p 53 following androgen withdrawal . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In addition , cells overexpressing bcl 2 or bcl xL proteins were as sensitive to 1 , 2 naphthoquinones as were control cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In addition , Go 6976 did not alter protein levels and subcellular distribution of the anti apoptotic molecules Bcl 2 and Bcl xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
AIDS KS cells expressed fas , bcl 2 , and bcl xL genes but lacked fasL and bax gene expression . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl xL , a member of the bcl 2 family of proteins is required for the survival of neurons early in development . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
IL 7 also delayed the decreases in the levels of c Myc , Bcl 2 , and Bcl xL that occur upon loss of 5 Abl kinase activity . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 , bcl xL , bcl xS , and bax levels were unaffected by CBFbeta SMMHC . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
IFN alpha / beta did not raise the levels of Bcl 2 or Bcl XL in T cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The Bax conformational change is prevented by Bcl 2 and Bcl xL but not by caspase inhibitors . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
This inactivated BAD is held by the 14 3 3 protein , freeing BCL XL and BCL 2 to promote survival . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We detected transcripts for the anti apoptotic genes bcl 2 , bcl xL , and hsp 70 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
BA enhances the levels of BAX and BCL 2 proteins but does not alter the levels of BCL xS or BCL xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The expression of Bcl 2 , Bcl xL , or Bax was largely unaffected . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The cytochrome c releasing activity was not blocked by caspase inhibition , but was antagonized by Bcl 2 or Bcl xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The levels of Bcl 2 , Bcl xL , and Bax were not altered by cisplatin treatment and mitogen rescue . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The Bcl 2 family members , Bcl 2 , Bcl xl , and Bax , appear not to be involved in this process . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
BACKGROUND : Bcl xL is the predominant anti apoptotic Bcl 2 family member in the liver . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl XL and bcl 2 expression in squamous epithelial carcinomas of the head neck ] . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Anti apoptotic proteins of the Bcl 2 family , notably Mcl 1 and Bcl XL , may be involved in mediating the response to E2F 1 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Western blot analysis demonstrated that neither p 53 nor Bcl 2 , Bcl XL and Bax protein expression changed during anoikis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
IRS 2 but not IRS 3 binds to Bcl 2 , and IRS 1 associates with Bcl XL but not with Bax or Bik . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Consistent with that observation , anti CD3 / CD40L did not enhance the antiapoptotic proteins Bcl 2 and Bcl xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
However , neither the presence of proapoptotic Bax nor antiapoptotic Bcl 2 or Bcl XL affected tBid degradation . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 , Bcl xL , Bad , Bak , and Bax levels were not altered by either treatment . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Western blot assessed caspase 3 , caspase 8 , Bcl 2 , and Bcl XL protein expression . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We immunohistochemically examined the protein expression of Bcl 2 , Bcl XL , Mcl 1 , and Bax . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Other members of the Bcl 2 family ( Bag 1 , Bak , Bax , and Bcl xL ) were not altered in expression . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The cascade is also anti apoptotic by modulation of Bcl 2 , Bcl xL and BAD function . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Suppression of expression of bcl 2 and bcl xL genes using antisense oligonucleotides : a new approach to cancer therapy ] . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Furthermore , quercetin markedly inhibited the expression of anti apoptotic protein Bcl 2 but hardly influenced Bcl XL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Concomitantly , there were significant decreases in the anti death genes Bcl 2 and Bcl XL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 and Bcl XL prevent neuronal apoptosis during development , neurodegenerative disease , and trauma . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Moreover , Bcl XL , but not Bcl 2 protein expression are reduced . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
With respect to apoptosis induction , decreased levels of the apoptosis blocking proteins Bcl 2 and Bcl xL were also observed . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
During these cultures , the expression of Bcl 2 was suppressed by N 17 , 694F , or Delta p 85 , and that of Bcl XL by N 17 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
However , in HCa 1 , the application of a priming dose increased radiation induced Bcl XL and Bcl XS , but not Bcl 2 or Bax . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The bcl xl form , similar to bcl 2 , inhibits apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
However , Bcl 2 , Bcl XL , and Bad all remained unchanged in wogonin and fisetin treated HL 60 cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Changes in the apoptosis related proteins , bcl 2 , bcl xL , and bax were analyzed by Western blotting . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Both cell lines express almost the same levels of FADD , RIP , c FLIP , FAP 1 , Bax , Bcl 2 and Bcl XL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The gene expression of Bax , Bcl 2 and Bcl xL was analysed by Northern blotting . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 and Bcl XL protein levels were decreased in IFN alpha 2b treated rats . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl xL is a well characterized death suppressing molecule of the Bcl 2 family . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Induction of bcl xL may explain the observed redundancy in lymphomagenesis between transgenic EBNA 1 and bcl 2 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
IL 6 rescues the hyporesponsiveness of c Rel deficient B cells independent of Bcl xL , Mcl 1 , and Bcl 2 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Similarly , the levels of Bcl 2 , Bax and Bcl xL were unchanged in imexon treated cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The Bcl 2 family member Bcl xL has been demonstrated to provide resistance to chemotherapeutic agents including CBDCA . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl xL , a close homolog of Bcl 2 , is an important regulator of apoptosis and is overexpressed in human cancer . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
No or only minor changes in Bcl 2 , Bcl XL and Bax levels were observed . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Under the same conditions GM CSF up regulated production of BAX as well as Bcl 2 , Bcl XL , survivin , and XIAP . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Yeast strains were generated expressing nematode ced 9 , human bcl 2 , or chicken bcl xl genes . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
No changes were noted in the expression of mRNAs encoding Bcl 2 , Bcl xL , Bax , caspase 8 , caspase 3 , or GAPDH . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Mitochondrion harbors both antiapoptotic ( Bcl 2 , Bcl XL ) and apoptotic factors ( Smac / Diablo , Apaf 1 , cytochrome c ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
These inhibitors were found to be Mcl 1 and Bcl xL , two antiapoptotic members of the Bcl 2 family . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Antiapoptotic Bcl 2 protein levels were not changed by DDN , but the expression of Bcl xL was decreased . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Moreover , Bcl 2 and Bcl xL protect neurons from apoptosis , while Bax and Bcl xS may act as proapototic proteins . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
No change was detected in Bcl 2 , Bax , or Bcl xL proteins . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bax and Bcl xL proteins were not changed , although Bcl 2 proteins increased with troglitazone . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Heme oxygenase 1 , Bcl 2 and Bcl xl were not increased in ABO incompatible grafts at any time point . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In the present study , we have examined the roles played by the Bcl 2 family members Bcl xL and Bid in regulating this response . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 and Bcl xL expression were inhibited in a dose dependent fashion . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Enforced expression of PIM 2 ( 34 kDa ) kinase does not appear to regulate expression of BCL 2 , BCL xL , BIM , or BAX proteins . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 , Bcl w , A1 / Bfl 1 , and Boo / Diva failed to show the same capacity for binding to BBR as Bcl XL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The antiapoptotic effect was mediated by Bcl 2 expression but not by Bcl xL expression . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Defects in the mitochrondrial intrinsic pathway result from imbalances in expression levels of Bcl 2 , Bcl XL and Mcl 1 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Expression of Bcl 2 , Bcl xL , and Bax in JPX 9 cells was assessed with Western blot analysis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We have generated mouse ES cells that constitutively express Bcl XL , an antiapoptotic protein of Bcl 2 family . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
There were no significant changes in Bcl 2 , Bcl xl , and Bax protein expression after troglitazone treatment . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
While the levels of Bcl 2 and Bcl xL were relatively unchanged , these compounds induced a marked reduction in Mcl 1 level . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Expression of Bcl 2 mRNA and protein was down regulated , with no change in Bax or Bcl XL protein production . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The antiapoptotic Bcl 2 and Bcl xL proteins were downregulated , whereas the proapoptotic Bax was upregulated . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
They mimic normal beta selection by up regulating germline TCR Calpha transcripts , CD 2 , and Bcl xL and down regulating Bcl 2 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
TCDD did not cause significant changes in the relative gene expression of caspase 8 , Bcl 2 and Bcl xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Both ASA and indomethacin reduced the protein levels of Bcl 2 and Bcl xl , but upregulated those of Bax and Bcl xs . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
This process may involve up regulation of p27Kip1 and down regulation of cyclin A , Bcl 2 , and Bcl xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Similarly there was no change in expression of the majority of antiapoptotic genes ( bcl 2 , bcl xL , bcl w , NfkappaB ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Moreover , we showed that NCTD downregulated the expression of Bcl 2 in Ca 9 22 and Bcl XL in SAS . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Coincidently , Bcl 2 but not Bcl xL expression decreased , and caspase 3 was activated . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bad , however , bound tightly to Bcl 2 , Bcl xL , and Bcl w but only weakly to A 1 and not to Mcl 1 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The expression of Bcl 2 , Bcl xL and ICAD was reduced time dependently , whereas the expression of Bax was increased . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The increase in survival was associated with an increase in expression of mRNA of bcl xl but not bcl 2 and bax ex vivo . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
There was a decrease in the expression of anti apoptotic Bcl 2 and Bcl xL proteins , whereas pro apoptotic Bax was increased . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 and Bcl XL proteins were decreased by asiatic acid treatment . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Western blot analyses revealed that CT induced an elevation of bcl xL but not bcl 2 or proapoptotic factors bax , bak , and bad . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Immunoblot analysis of Bax , Bcl 2 , Bcl xL , and caspase 9 were performed . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The levels of apoptosis related proteins Bcl 2 , Bax , and Bcl XL were not modulated by boswellic acid acetate . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 or Bcl XL inhibited both these events . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In the heart , this cytosolic HSP 60 complexes with Bax , Bak and Bcl XL , but not with Bcl 2 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Overexpression of Bcl 2 or Bcl xL provided substantial protection of Ramos B and Jurkat T cells against zinc induced apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
REG Ialpha protein promoted Akt phosphorylation and enhanced Bcl xL and Bcl 2 expression in LoVo cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In addition , increased expression of Bcl 2 and Bcl xL and resistance to apoptosis upon serum withdrawal were found . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The expression levels of Mcl 1 and Bcl XL but not those of Bcl 2 , Bax , and Bak were suppressed by TSA or SK 7041 treatment . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
This correlated with expression of TNF , IkappaBalpha , Bcl 2 , Bcl xl , COX 2 and IL 6 , all regulated by NF kappaB . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NPD 1 also upregulates the anti apoptotic proteins Bcl 2 and Bcl xL and decreases pro apoptotic Bax and Bad expression . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In addition , the up regulation of bax , and the down regulation of bcl 2 and bcl xL , was observed . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Expression of the Bcl 2 family proteins , Bcl xL and Bag 1 , was increased in CCL 2 treated myocytes subjected to hypoxia . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
SCF up regulated the anti apoptotic genes , bcl 2 and bcl xL in an NFkappaB dependent manner . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Of note , the BH 3 domain of LASU 1 interacted with Mcl 1 but not with Bcl 2 or Bcl Xl . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
All of the four mouse MM cell lines examined expressed Bax , Bcl xL , c Myc , and caspase 3 but not Bcl 2 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We also show that overexpression of GABAAR alpha 1 causes apoptosis , which is blocked by the coexpression of Bcl 2 or Bcl XL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The aim of our study was to estimate the expression of the Bcl xL gene , a member of Bcl 2 family , in NSCLC patients . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
This activation of caspase 2 was also observed in cells protected from heat shock induced apoptosis by Bcl 2 or Bcl xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
After treatment with IDN 5109 , Bcl 2 and Bcl XL were down regulated , Bax was up regulated , and caspase 3 was activated . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
PS 341 activated the BH 3 only proteins Bik and Bim and down regulated Bcl 2 and Bcl xL mRNA and protein expression . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Expression of anti apoptosis protein BcL XL and BcL 2 in BMC were determined by immunohistochemistry . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Renal function , structure , and immunohistochemistry for Bcl 2 , Bcl XL , and Bax were analyzed . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl xL , an anti apoptotic member of the Bcl 2 family , was selected for confirmation by western blot analysis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Matrine did not alter the level of bcl 2 and bcl xL as well as bax . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Expression of Bcl 2 , Bcl XL and Bax proteins was investigated using immunohistochemistry . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Tyr / Phe restriction also inhibits Bcl 2 and Met restriction inhibits Bcl XL in mitochondria . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Western blot analysis showed that Matrigel induced the expression of bcl 2 , bcl xL , p 63 , and DeltaNp 63 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
At least two family members , Bcl xs and Bax , act in opposition to Bcl 2 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Signalling through Fas / APO 1 did not down regulate Bcl 2 or induce its antagonists Bax and Bcl xS . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
No changes in Bcl 2 , Bak , or Bcl xS were found after p 53 expression . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Detection of apoptosis and regulating proteins Bcl 2 and Bcl Xs in developing kidney of human embryos 2 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Host pancreatic RT PCR showed 235 bp or 250 bp bcl 2 and 181 bp bcl xS gene products . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
HSpin 1 bound to Bcl 2 and apoptosis regulator Bcl 10 ( Bcl xL ) , but not to proapoptotic members such as Bcl 2 associated 10 protein and Bcl 2 homologous antagonist killer , in cells treated with TNF alpha . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In order to test a hypothesis that the expression of bcl 10 gene promotes apoptosis by antagonizing the function of bcl 2 gene product , time course of the expression of bcl 10 was investigated using the dexamethasone treated rat thymocytes which were undergoing apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Similarly , the expression of bcl 2 , bcl 10 , bax and IL 1 beta converting enzyme did not correlate with susceptibility to anti IgM induced PCD . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 10 and Bcl 2 inhibit TNF and Fas induced apoptosis and activation of phospholipase A 2 in breast carcinoma cells . ^^^ These cDNAs encoded for Bcl 2 and Bcl 10 . ^^^ Expression of either bcl 2 or bcl 10 in these cells rendered them completely resistant to lysis induced by either TNF or Fas . ^^^ Activation of PLA 2 was completely blocked whereas activation of NF kappa B was unaffected by overexpression of either bcl 10 or bcl 2 . ^^^ These data suggest an involvement of PLA 2 in both TNF and Fas mediated cytotoxicity and a novel mechanism of action for bcl 2 and bcl 10 , i . e . inhibition of arachidonic acid metabolism , by which they may , in addition of apoptosis , modulate inflammation . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Primitive human hematopoietic precursors express Bcl 10 but not Bcl 2 . ^^^ To better understand the maintenance of long term survival in the hematopoietic stem cell population , we evaluated the expression patterns of Bcl 2 and Bcl 10 in primitive hematopoietic precursor populations . ^^^ Our data show that the most primitive hematopoietic precursors express Bcl 10 but not Bcl 2 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In this report , we have demonstrated that the signal mediated by CD40L acts upon bcl 10 , a bcl 2 homologue . bcl 10 expression is strongly enhanced by CD 40 receptor engagement , while there is little or no induction by sIg cross linking . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
To begin to investigate this possibility , we have cloned and characterized the murine bcl 10 gene , whose human counterpart displays striking homology to bcl 2 . ^^^ In addition , the bulk of the bcl xL product localizes to the periphery of mitochondria as assessed by a bcl xL tag expression system , suggesting that both Bcl 2 and Bcl xL proteins prevent cell death by a similar mechanism . bcl xL is the most abundant bcl 10 mRNA species expressed in embryonic and adult tissues . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 and its relatives bcl 10 and bax encode intracellular membrane bound proteins that share homology in three domains with a wider family of viral and cellular proteins . ^^^ The Bcl 2 and Bcl 10 proteins enhance the survival of lymphocytes and other cell types but do not promote their proliferation . ^^^ High levels of Bax or of a smaller Bcl 10 variant antagonize the survival function of Bcl 2 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Expression of Bcl 2 , Bcl 10 , and Bax after T cell activation and IL 2 withdrawal . ^^^ Bcl 2 , bcl 10 , and bax genes code for proteins that affect the susceptibility of cells to apoptosis . ^^^ In general , the expression of bcl 2 or bcl 10 inhibits apoptosis while bax promotes apoptosis . ^^^ Bcl 2 and Bax proteins vary coordinately , but Bcl 10 varies independently : Bcl 2 and Bax are higher in splenic T cells than in thymocytes , and their levels increase even more after T cell activation . ^^^ When CTLL 2 cells or activated T cells are starved of IL ( IL 2 ) , the level of Bcl 10 but not Bcl 2 protein drops before the onset of apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 10 protein , which is related to Bcl 2 , is present essentially in the nervous system and the immune system , under 2 different forms : Bcl XL , like Bcl 2 , is able to prevent apoptotic death of cultured lymphocytes ; in contrast , Bcl XS , which differs from the former one by a deletion of 63 amino acids in the region of greatest homology between Bcl XL and Bcl 2 , is unable to prevent this apoptotic death and even counteracts the protective effect of Bcl 2 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
There are no cytokine related changes in Bcl 2 , Bax , or Bcl 10 protein levels that could account for the modulation of G 1 arrest versus apoptosis by growth factors . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We found constitutive Bcl 2 and Bcl 10 expression , which remained unaltered after sIg cross linking , in both resistant and sensitive cells . ^^^ This and other experiments suggest that constitutive expression of Bcl 2 or Bcl 10 alone is not sufficient to protect from activation induced cell death in B cells . ^^^ We therefore propose a potential role of the novel bcl 2 gene family members bcl 10 and bax in surface IgM triggered apoptosis . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The proto oncogene bcl 2 , isolated from the t ( 14 ; 18 ) chromosomal breakpoint in follicular B lymphoma , and a bcl 2 related gene bcl 10 ( ref . 4 ) prevent apoptotic cell death induced by various treatments . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The expression of bcl 10 protein , a bcl 2 related protein present in cortical thymocytes , activated lymphocytes , and plasma cells of reactive lymph nodes , was investigated in 44 cases of Hodgkin ' s disease ( HD ) in parallel with bcl 2 and Epstein Barr virus ( EBV ) status . ^^^ Of interest , 100 % of the EBV positive samples were positive for bcl 10 , whereas only 38 % of these cases were bcl 2 positive . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Discordant expression of Bcl 10 and Bcl 2 by keratinocytes in vitro and psoriatic keratinocytes in vivo . ^^^ In this report , we examined the expression of proteins associated with promoting ( Fas ) or preventing ( Bcl 2 , Bcl 10 , CD 40 ) apoptosis in the normal , psoriatic , and malignant keratinocyte . ^^^ Only faint Bcl 2 staining was detected in cultured keratinocytes exposed to IFN gamma and TPA compared with the prominent expression of Bcl 10 . ^^^ In contrast , malignant keratinocytes in basal cell carcinomas expressed high levels of Bcl 2 , but minimal Bcl 10 , and no Fas . ^^^ The overexpression of Bcl 10 in psoriasis , or Bcl 2 in basal cell carcinomas , may contribute to the longevity of these cells by blocking the normal apoptotic process involved in the terminal differentiation program of epidermal keratinocytes . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Since bcl 2 appears dispensable for neuronal survival , we have examined the expression and function of bcl 10 , another member of the bcl 2 family of death regulatory genes . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Of note , however , we found that IL 6 mediated suppression of B 9 apoptosis does not involve induction of endogenous bcl 2 expression but is associated instead with the upregulation of cellular bcl 10 mRNA and Bcl xL protein . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl xL is expressed in neuroblastoma cells and modulates chemotherapy induced apoptosis . bcl 10 is a new member of the bcl 2 gene family and is highly expressed in neural tissues . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Herein we have characterized changes in the expression of the bcl 2 protooncogene ( an inhibitor of apoptosis ) , the bax gene ( an inducer of apoptosis ) , and the bcl 10 gene ( which encodes both bcl xlong , an inhibitor of apoptosis , and bcl xshort , an inducer of apoptosis ) during gonadotropin stimulated follicular development in vivo and during atresia of antral follicles incubated in vitro . ^^^ Complementary DNA fragments corresponding to rat bcl 2 , rat bax , and rat bcl 10 coding sequences were obtained by the reverse transcription polymerase chain reaction ( RT PCR ) technique using total RNA prepared from immature rat ovaries . ^^^ Northern blot analysis of steady state bcl 2 , bax , and bcl 10 messenger RNA ( mRNA ) levels in total RNA prepared from ovaries of immature rats before and after in vivo priming with 10 IU equine CG ( eCG ) revealed that eCG induced follicular growth and survival were associated with a relatively constitutive level of bcl 2 and bcl 10 expression but markedly reduced levels of bax mRNA ( 29 + / 5 % of saline treated control animals ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 and Bcl 10 : regulatory switches for lymphoid death and survival . ^^^ Of these , bcl 2 and bcl 10 exhibit a striking pattern of regulation during lymphoid maturation and can inhibit several forms of apoptotic cell death . ^^^ Here , Gabriel Nez and colleagues review recent developments in the field , particularly focusing on the role of the Bcl 2 and Bcl 10 proteins in regulating lymphoid death and survival . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 and a related gene , Bcl 10 , inhibit several forms of apoptosis . ^^^ Herein , we report that internucleosomal DNA fragmentation , characteristic of apoptosis and induced by ionizing radiation , is accompanied by concomitant decreases in Bcl 2 and Bcl 10 mRNA levels in HL 60 and U 937 human leukemia cells . ^^^ Apoptotic DNA fragmentation after exposure to TNF alpha and C 2 ceramide was also associated with down regulation of Bcl 2 mRNA in HL 60 and U 937 cells , while Bcl 10 mRNA production was unaffected . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Massive cell death of immature hematopoietic cells and neurons in Bcl 10 deficient mice . bcl 10 is a member of the bcl 2 gene family , which may regulate programmed cell death . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We have previously demonstrated that the gonadotropin mediated inhibition of apoptosis in ovarian granulosa cells is linked to changes in the expression of several cell death related genes , including members of the bcl 2 gene family ( bcl 2 , bax , and bcl 10 ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We have studied the expression of the apoptosis regulating genes bcl 2 , bcl 10 , bax and APO 1 / fas ( CD 95 ) in human breast cancer . ^^^ We therefore propose that dysregulation of apoptosis contributes to the pathogenesis of breast cancer , at least in part , due to an imbalance between anti apoptosis genes ( such as bcl 2 / bcl 10 ) and apoptosis promoting genes ( bax ) . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In many cases , these patterns of Bcl 10 expression were strikingly different from those reported previously for Bcl 2 , suggesting that Bcl 10 and Bcl 2 regulate cell life and death at different stages of cell differentiation through tissue specific control of their expression . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Interactions of the Bcl 2 protein with itself and other members of the Bcl 2 family , including Bcl 10 L , Bcl 10 S , Mcl 1 , and Bax , were explored with a yeast two hybrid system . ^^^ Bcl 2 also interacted with Bcl 10 L and Mcl 1 and with the dominant inhibitors Bax and Bcl 10 S . ^^^ Bcl 10 L displayed the same pattern of combinatorial interactions with Bcl 2 family proteins as Bcl 2 . ^^^ This cytotoxicity could be abrogated by B 42 fusion proteins containing Bcl 2 , Bcl 10 L , or Mcl 1 but not those containing Bcl 10 S ( an alternatively spliced form of Bcl 10 that lacks a well conserved 63 amino acid region ) . ^^^ The findings suggest a model whereby Bax and Bcl 10 S differentially regulate Bcl 2 function , and indicate that requirements for Bcl 2 / Bax heterodimerization may be different from those for Bcl 2 / Bcl 2 homodimerization . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We report the cloning and initial characterization of the mouse homologues of the bcl 2 related gene , bcl 10 . ^^^ We compare these to the two major isoforms of human bcl 10 that were previously identified , bcl xLong ( bcl xL ) which has death repressor activity similar to bcl 2 , and bcl xShort ( bcl xS ) , an alternative mRNA splice product that deletes a highly conserved domain shared by bcl 2 family members and promotes cell death in transfection studies . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Sequence analysis of the BHRF 1 protein disclosed similarity with the recently described bcl 2 homologues bcl 10 ( 32 % ) and bax ( 34 % ) over the carboxyl portion , with several domains of complete identity . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We report the isolation of bcl 10 , a bcl 2 related gene that can function as a bcl 2 independent regulator of programmed cell death ( apoptosis ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Here , we have investigated the possibility that the three recently identified Bcl 2 homologues , Bax , Bcl 10 , and Mcl 1 , could be involved instead . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
A 20 expression was correlated with resistance to injury in fourth passage HUVEC , but there was no correlation between bcl 2 and bcl 10 expression and resistance to injury . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Immunoblot analysis of cellular expression of Bcl 2 family proteins , Bcl 2 , Bax , Bcl 10 and Mcl 1 , in human peripheral blood and lymphoid tissues . ^^^ Several homologues of the bcl 2 gene , such as bax , bcl 10 or mcl 1 , have recently been identified . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Phylogenies were inferred from both the nucleic acid and amino acid sequences of the human , murine , rat , and chicken sequences for BCL 2 and BCL 10 , human MCL 1 , murine A 1 , the nematode Caenorhabditis elegans and Caenorhabditis briggsiae ced 9 proteins , and the sequences BHRF 1 from Epstein Barr and LMW 5 HL from African swine fever viruses . ^^^ All the treeing methods employed ( distance matrix , maximum likelihood , and parsimony ) supported a tree in which the proapoptotic proteins BCL 2 and BCL 10 represent the most recent additions to the group . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Differential regulation of bcl 2 and bcl 10 by CD 3 , CD 28 , and the IL 2 receptor in cloned CD4+ helper T cells . ^^^ Resting T cells were highly resistant to spontaneous death in the absence of exogenous stress , and they expressed low levels of bcl 10 protein and no detectable bcl 2 . ^^^ Incubation with IL 2 prevented this cell death and led to a large increase in bcl 2 protein expression and only a modest up regulation in bcl 10 . ^^^ The combination of anti CD 3 and anti CD 28 mAbs was also effective in protecting the cells against radiation induced apoptosis ; however , this protection was associated predominantly with bcl 10 up regulation , and only a small induction of bcl 2 protein was observed . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In mammalian cells , the Bcl 2 and Bcl 10 ( L ) proteins suppress programmed cell death whereas the topographically similar Bax protein accelerates the apoptotic process . ^^^ Recently published data suggest that expression of the human Bax alpha gene is lethal for the yeast Saccharomyces cerevisiae and that this toxicity can be overcome by co expressing Bcl 2 or Bcl 10 ( L ) . ^^^ When murine Bcl 2 is fused to the membrane anchor of yeast mitochondrial Mas 70 protein , the Bcl 2 variant mBcl 2 mma rescues not only petites but also grandes , just like human Bcl 10 ( L ) . ^^^ Our results indicate that the process involving Bax induced growth inhibition followed by possible lethality , and the rescuing effect of Bcl 2 and Bcl 10 ( L ) is linked to yeast mitochondrial function . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The available data therefore suggest that bcl 10 fulfils two roles in B cells : it promotes survival of immature B cells ( which lack bcl 2 ) and secondly , it apparently plays an additional role in protecting activated mature B cells ( perhaps those in germinal centers ) from apoptotic stimuli . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 10 is a member of the bcl 2 family of proteins which are characterized by their ability to modulate apoptosis . ^^^ Alternative splicing results in two distinct bcl 10 mRNAs encoding a long isoform , bcl xL , which acts as a bcl 2 agonist ; and a short isoform , bcl xS , which inhibits bcl 2 effects . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Our recent observations that overexpression of the anti apoptotic proto oncogene bcl 2 and a bcl 2 related gene , bcl 10 , prevents hypoxic cell death suggest that hypoxia induces apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
IGF 1 or insulin suppresses ICE mediated cell death without affecting the expression levels of Bcl 2 , Bcl 10 , or Bax . ^^^ Taken together , these results indicate that ICE is activated by growth factor deprivation , and IGF 1 is able to suppress ICE mediated cell death through a mechanism independent of the expression of Bcl 2 , Bcl 10 , or Bax . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Immunohistochemical analysis of bcl 2 , bax , bcl 10 , and mcl 1 expression in prostate cancers . ^^^ Using antibodies specific for the Bcl 2 , Bax , Bcl 10 , and Mcl 1 proteins in combination with immunohistochemical methods , we examined for the first time the expression of these bcl 2 family genes in 64 cases of adenocarcinoma of the prostate , including 10 Gleason grade 2 to 4 tumors , 21 grade 5 to 7 tumors , 17 grade 8 to 10 tumors , 8 lymph node metastases , and 8 bone metastases . ^^^ The findings suggest that expression of several anti apoptotic members of the bcl 2 gene family , including bcl 2 , bcl 10 , and mcl 1 increases during progression of prostate cancers , a finding that may be relevant to the hormone insensitive , metastatic phenotype of most advanced adenocarcinomas of the prostate . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In contrast to the increased Bcl 10 expression , the intensity of Bcl 2 immunostaining was greater than that of normal colonic mucosa in only 3 of 30 ( 10 % ) carcinomas and , in fact , was lower than that of adjacent normal epithelia ] cells in 25 ( 83 % ) cases ( P = 0 . 0001 ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 , Bcl 10 and Bax are members fo a family of cytoplasmic proteins that influence cell survival . ^^^ Whereas increased expression of Bcl 2 or Bcl 10 promotes cell survival following withdrawal of survival factors , increased expression of Bax is thought to suppress survival . ^^^ Surprisingly , overexpression of Bax rescued populations of sensory neurons deprived of nerve growth factor , as did overexpression of Bcl 2 and two Bcl 10 variants , Bcl XL and Bcl Xbeta . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 10 , a member of the Bcl 2 family , has two alternatively spliced forms , Bcl 10 ( L ) and Bcl 10 ( S ) . ^^^ Bcl 10 ( L ) , like Bcl 2 , is able to protect cells from a wide variety of apoptotic stimuli . ^^^ Bcl 10 ( S ) , as a result of alternative splicing , lacks 63 amino acids that comprise the region of greatest amino acid identity between Bcl 10 ( L ) and Bcl 2 . ^^^ Coimmunoprecipitation from mammalian cells demonstrates that Bcl 10 ( S ) does not show an observable ability to form heterodimers with other Bcl 2 family members . ^^^ Thus , Bcl 10 ( S ) does not appear to function by competitively disrupting the formation of dimers composed of other Bcl 2 family members . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We have assessed during B cell development , the regulation and function of bcl 10 , a member of the bcl 2 family of apoptosis regulatory genes . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Mutant p 53 gene expression was detected in the majority of the cell lines and no relationship between p 53 gene expression and the expression of either bcl 2 , bcl 10 or bax was observed . ^^^ No changes in bcl 2 , bcl 10 and bax gene expression were observed in multidrug resistant cell lines compared with their drug sensitive counterparts . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The expression of a cell death inducing gene , Bax , was investigated in 52 cases of Hodgkin ' s disease in parallel with Epstein Barr virus and was compared with the immunodetection of other apoptosis regulating proteins , Mcl 1 , Bcl 2 , and Bcl 10 . ^^^ Mcl 1 was positive in 80 % of the cases , whereas Bcl 2 and Bcl 10 were found in 53 % and 88 % of the cases , respectively . ^^^ With the exception of 1 case , all Bax positive tumors also expressed either Bcl 2 , Bcl 10 , Mcl 1 , or combinations of these anti apoptotic proteins . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Recent work also has revealed the existence of several bcl 2 related genes that also can inhibit ( e . g . , bcl 10 ( L ) and Mcl 1 ) or activate ( e . g . , bax , bcl 10 ( s ) , bag , and bad ) apoptosis in several systems . ^^^ Significant bcl 10 ( L ) but not bcl 2 expression was also detected in three other murine myeloma cell lines ( MOPC 315 , RPC 5 . 4 , and J 558 ) derived from different plasmacytoma tumors . ^^^ These results indicate a predominant role of bcl 10 ( L ) in preventing apoptosis in myeloma cells and suggest that the expression of bcl 2 or bcl 10 ( L ) genes in B cell tumors depends on the differentiation stage of the precursor normal cell . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
This protective effect of Bcl 2 occurs in the absence of significant variations , in the stimulated livers , in the level of expression of other proteins also involved in resistance or sensitivity to apoptosis , namely Bcl 10 , Bax , Bad , Bak , and p 53 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Introduction of Bcl 10 ( L ) or Bcl 2 into other factor dependent cell lines may also simplify their maintenance without significantly affecting their utility in bioassays . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The expression of apoptosis regulating proteins , Bcl 2 , Bax , Mcl 1 , and Bcl 10 , was evaluated by immunohistochemical methods in 39 cases of thyroid carcinomas . ^^^ Normal thyroid tissues showed a consistent expression of Bcl 2 and Mcl 1 whereas Bax and Bcl 10 proteins were essentially absent from most follicular thyroid cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The expression of the apoptosis regulating genes Bcl 2 , Bcl 10 , Bax , Mcl 1 , and p 53 analyzed in 4 cases of human immunodeficiency virus ( HIV ) associated Hodgkin ' s disease , in 36 cases of HIV related non Hodgkin ' s lymphomas ( NHLs ) , and in 109 cases of non HIV related NHLs by using immunohistochemistry . ^^^ For the HIV related NHL samples , 36 , 66 , 88 , 100 , and 94 % of the cases were Bcl 2 , Bcl 10 , Bax , Mcl 1 , and p 53 were found to be expressed in 69 , 65 , 82 , 83 , and 42 % , respectively . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 10 rather than Bcl 2 mediates CD 40 dependent centrocyte survival in the germinal center . ^^^ Purified B cell fractions enriched for centrocytes express high amounts of Bcl 10 and relatively low amounts of Bcl 2 , whereas fractions enriched for centroblasts lack significant levels of both proteins . ^^^ These data suggest that Bcl 10 rather than Bcl 2 may rescue centrocytes during selection in the germinal center . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The results show that : ( 1 ) As2O3 triggers relatively specific NB 4 cell apoptosis at micromolar concentration , as proved by morphology , histogramic related nuclear DNA contents , and DNA gel eletrophoresis . ( 2 ) As2O3 does not influence bax , bcl 10 , c myc , and p 53 gene expression , but downregulates bcl 2 gene expression at both mRNA and protein levels . ( 3 ) As2O3 induces a significant modulation of the PML staining pattern in NB 4 cells and HL 60 cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Fas , Bcl 2 family ( Bcl 2 , Bcl 10 and Bax ) and ICE family ( ICE , Ich 1 ) were found to be involved in tumorigenesis of certain brain tumors . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Thus , like Bcl 2 and Bcl 10 , the Bcl w protein promotes cell survival , in contrast to other close homologues , Bax and Bak , which facilitate cell death . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Apoptosis of bcl 10 deficient telencephalic cells in vitro . bcl 10 is a member of the bcl 2 gene family , which is expressed at high levels in the embryonic brain . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Enhanced expression of BCL 2 was relatively selective as treatments had no effect on expression of Ig light chains , BCL 10 , or actin . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Despite the down regulation of bcl 2 in MCF 7 / Adr cells and equal levels of bcl 10 , and bax proteins in both cell lines , cytoplasmic DNA histone complexes induced by doxorubucin , taxol , vincristine and VP 16 indicate that MCF 7 / Adr cells are highly resistant to apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Cell density increases Bcl 2 and Bcl 10 expression in addition to survival of cultured cerebellar granule neurons . ^^^ The proto oncogene bcl 2 and its family members , bcl 10 and bax are recognized as major regulators of cell death and survival . ^^^ Although Bcl 2 and Bcl 10 are expressed in brain , little is known how they are regulated in neurons . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The gene bcl 10 , which is related to a bcl 2 , regulates programmed cell death . bcl 10 may function in the development of the nervous system . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Localization of bcl 2 , bax , and bcl 10 mRNAs in the developing inner ear of the mouse . ^^^ In situ hybridization was employed to study the expression of bcl 2 mRNA and its family members , bax and bcl 10 mRNAs , in the developing inner ear . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We examined the expression of Fas and bcl 2 family gene products , such as Bcl 2 , Bcl 10 , Bax , and Mcl 1 , in human tonsillar B cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Altered expression of Bcl 2 , Bcl 10 , Bax , and c Fos colocalizes with DNA fragmentation and ischemic cell damage following middle cerebral artery occlusion in rats . ^^^ A decrease in immunoreactivity for Bcl 2 , and Bcl 10 and an increase in immunostaining for Bax was observed exclusively in neurons within the ischemic cortex and thalamus . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The apoptosis regulating proteins Bcl 2 , Bax , Bcl 10 , Bak , and Mcl 1 were examined by immunohistochemical methods in 48 archival specimens of adenocarcinoma of the stomach , and the results were correlated with tumor histology ( intestinal versus diffuse pattern ) and clinical stage ( early versus late stage disease , ie , stages 1 and 2 versus stage 3 ) . ^^^ Tumor cells containing immunostaining for the anti apoptotic proteins Bcl 2 , Bcl 10 , and Mcl 1 were present in 26 ( 54 % ) , 41 ( 85 % ) , and 36 ( 75 % ) of the 48 cases evaluated , respectively , whereas immunopositivity for the pro apoptotic proteins Bax and Bak was found in 44 ( 92 % ) and 42 ( 88 % ) specimens Comparisons of these immunostaining results with tumor histology revealed statistically significant differences for Bax ( P = 0 . 03 ) , Bcl 10 ( P = 0 . 003 ) , and Mcl 1 ( P = 0 . 005 ) , which were all more frequently immunopositive for tumors with an intestinal than a diffuse histological pattern ( chi 2 analysis ) . ^^^ The immunointensity for the Bcl 2 , Bcl 10 , and Mcl 1 proteins was stronger in tumor cells compared with normal foveolar cells in 7 ( 21 % ) , 15 ( 44 % ) , and 8 ( 2 . 1 % ) of 34 cases , respectively , whereas the immunointensity of the proapoptotic proteins Bax and Bak was reduced compared with normal cells in 8 ( 24 % ) and 24 ( 71 % ) cases . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Messenger RNA ( mRNA ) expression of bcl 2 , bcl 10 , bax , and c myc in T and B cells was determined by enzyme linked immunosorbent assay polymerase chain reaction ( ELISA PCR ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Using in situ hybridization , Northern blotting and RT PCR we studied the post ischemic expression of bcl 2 , bcl 10 , bax and ICE . ^^^ One day following 5 min or 10 min of global ischemia bcl 2 and bcl 10 mRNAs were induced in CA 1 hippocampal pyramidal neurons while bax was unchanged . ^^^ By 72 h after ischemia the expression of bcl 2 , bcl 10 and bax mRNAs decreased in CA 1 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
One distant member , BAD , heterodimerizes with BCL 10 ( L ) or BCL 2 , neutralizing their protective effect and promoting cell death . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
This effect is achieved in the absence of any detectable changes in the levels of BCL 2 , BAX or BCL 10 proteins and is independent of proliferative , MAP kinase dependent effects of BCR ABL kinase . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We have investigated the effect of DNA damage on the expression of BCL 10 , a member of the BCL 2 family . ^^^ Like BAX , another member of the BCL 2 family and a p 53 regulated gene , the induction of BCL 10 ( L ) was dependent on normal p 53 function and required that cells have an apoptosis susceptible phenotype . ^^^ These results indicate that BCL 2 and BCL 10 ( L ) behave differently in response to DNA damage treatment even though they both are able to protect cells from p 53 mediated apoptosis ; along with down regulation of BCL 2 , BCL 10 ( L ) was up regulated by IR in human cells with wild type p 53 and susceptibility to IR induced apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Expression pattern of candidate cell death effector proteins Bax , Bcl 2 , Bcl 10 , and c Jun in sensory and motor neurons following sciatic nerve transection in the rat . ^^^ Bcl 2 and Bcl 10 proteins were present only at moderate to low levels . ^^^ In the L 5 dorsal root ganglia ( DRG ) levels of Bax , Bcl 2 , and Bcl 10 proteins were highly variable . ^^^ It should be noted , however , that numerous strongly Jun positive DRG neurons contained low levels of Bax or high levels of Bcl 2 and Bcl 10 immunoreactivity . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Modulation of apoptosis associated genes bcl 2 , bcl 10 , and bax during rat liver regeneration . ^^^ The results indicated that transcripts for both bcl 10 and bcl 2 exhibited similar patterns of expression during LR with peaks at 6 h post PH . ^^^ Western blot analyses of Bcl 2 and Bcl 10 proteins showed no significant change through 96 h of LR , whereas Bax protein levels cycled in parallel with its mRNA . ^^^ In conclusion , the apoptosis associated genes bcl 2 , bcl 10 and bax are modulated at the transcript and protein levels during LR , suggesting a role for these gene products in normal liver growth . ^^^ Furthermore , unlike bax , steady state protein and transcript levels are uncoupled for both bcl 2 and bcl 10 , suggesting a role for translational regulation during LR after PH . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Apoptosis resistance in the metastatic cells was associated with higher levels of expression of the cell death suppressor BCL 2 and lower levels of the death promoters BAX and BAK than were detected in the nonmetastatic LNCaP Pro 5 cells , whereas levels of two other BCL 2 family members ( BCL 10 ( L ) and BAD ) were indistinguishable . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl xS enhances adenoviral vector induced apoptosis in neuroblastoma cells . bcl 10 is a member of the bcl 2 family of genes and by alternative splicing gives rise to two distinct mRNAs : bcl xL and bcl xS . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Apoptosis repressor genes Bcl 2 and Bcl 10 long are expressed in the rat brain following global ischemia . ^^^ The proto oncogenes bcl 2 and bcl 10 long have been shown to suppress apoptotic cell death in a variety of in vitro systems and cell lines , including neurons . ^^^ To begin to address this issue , we studied the expression of bcl 2 , and bcl 10 mRNA and protein after global ischemia in the rat . ^^^ Both bcl 2 and bcl 10 long mRNA were expressed in CA 1 , CA 3 , and the molecular layer of the dentate after ischemia . ^^^ However , bcl 2 and bcl 10 protein were expressed only in CA 3 and dentate . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
To clarify the possible roles of the genes involved in the cell death program , this study examined the expression of three members of the interleukin 1 beta converting enzyme ( Ice ) gene family ( Ice , Nedd 2 , and Yama / CPP32 ) and two members of the bcl 2 gene family ( bcl 2 and bcl 10 ) in the rat brain after permanent occlusion of the middle cerebral artery . ^^^ The expression of bcl 2 and bcl 10 remained constant after the ischemic insult . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bax alpha can heterodimerize with Bcl 2 and Bcl 10 ( L ) , countering their effects , as well as promoting apoptosis on overexpression . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Analysis of oncogenes regulating apoptotic cell death revealed a marked decrease of bcl 2 in combination with a moderate reduction of bax protein , but a striking overexpression of the long form of the bcl 10 protein . ^^^ The data suggest that overexpression of bcl 10 L results in an unusual phenotype with broad cross resistance to non MDR related cytotoxins in vitro , and provide an interesting example of spontaneous overexpression of another member of the bcl 2 gene family in cancer . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Immunohistochemical examination of the expression of the apoptotic checkpoint proteins , Bcl 10 , Bax and Bcl 2 , demonstrated that they are expressed in the terminal endbud . ^^^ Bcl 10 and Bcl 2 expression is highest in the body cells and lowest in the nonapoptotic cap cells , implying that their expression is associated with increased apoptotic potential . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Northern blot analysis revealed a rapidly increased expression of the bcl 10 ( s ) gene without any change in the expression of the bcl 2 gene , indicating that HUVECs under chloroquine were undergoing apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Other investigated apoptosis associated factors comprised interleukin 1 beta converting enzyme ( ICE ) , mediating cell death by cleavage of actin filaments , as well as bcl 2 and bcl 10 , both inhibiting apoptosis by acting as antioxidants . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Distinct neurodevelopmental patterns of bcl 2 and bcl 10 expression are altered in glioneuronal hamartias of the human temporal lobe . ^^^ The normal pattern of bcl 2 and bcl 10 expression was studied in postmortem human fetal and adult temporal lobes . ^^^ Formalin fixed , paraffin embedded tissue sections were probed for bcl 2 and bcl 10 in immunohistochemical studies using well characterized primary antibodies that had been raised against epitopes that are not shared by these proteins . ^^^ However , bcl 2 immunoreactivity gradually decreased to weak or nondetectable levels between 20 and 39 weeks GA , while strong bcl 10 staining of neurons persisted throughout fetal development and into adulthood . ^^^ Twenty eight temporal lobe resections from children and adults ranging in age from 1 to 45 years ( mean=19 years ) with intractable epilepsy were then screened for differences in the pattern of bcl 2 and bcl 10 expression compared to normal controls . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We show that , following IL 3 starvation , mRNA and protein levels of Bcl 10 but not Bcl 2 decrease rapidly preceeding the onset of death . ^^^ The second one corresponds to long term survival more than 24 h survival and is strongly correlated with the induction of Bcl 10 but not Bcl 2 gene expression . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Immunohistochemical analysis of Bcl 2 , Bcl 10 , Mcl 1 , and Bax in tumors of central and peripheral nervous system origin . ^^^ The expression of Bcl 2 , Bcl 10 , Mcl 1 , and Bax was examined by immunohistochemical methods in 93 tumors of nervous system origin , including 49 gliomas ( 30 astrocytomas and 19 glioblastoma multiforme ( GMs ) ) , 16 medulloblastomas ( MBs ) , 19 neuroblastomas ( NBs ; 9 undifferentiated and 10 differentiated ) , and 9 miscellaneous neuroectodermal neoplasms . ^^^ Among the 49 gliomas , immunopositivity ( defined as > or = 10 % ) was observed for Bcl 2 in 45 ( 92 % ) , Bcl 10 in 48 ( 98 % ) , Mcl 1 in 49 ( 100 % ) , and Bax in 48 ( 98 % ) of 49 specimens . ^^^ Of the 16 MBs , immunopositivity was found for Bcl 2 in 4 ( 25 % ) , Bcl 10 in 9 ( 56 % ) , Mcl 1 in 8 ( 50 % ) , and Bax in 16 ( 100 % ) of the cases . ^^^ The intensity of immunostaining was strong for Bcl 2 in only 1 ( 6 % ) specimen , for Bcl 10 in 3 ( 19 % ) , and for Mcl 1 in 2 ( 12 . 5 % ) , in contrast to Bax immunostaining , which was strong in 12 ( 75 % ) tumors . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Neonatal diethylstilbestrol treatment alters the estrogen regulated expression of both cell proliferation and apoptosis related proto oncogenes ( c jun , c fos , c myc , bax , bcl 2 , and bcl 10 ) in the hamster uterus . ^^^ As part of a project to investigate the molecular and cellular mechanisms responsible for this phenomenon , expression of several proto oncogenes ( c jun , c fos , c myc , bax , bcl 2 and bcl 10 ) was compared in estrogen stimulated uteri from control versus neonatally DES treated hamsters . ^^^ In conclusion , neonatal DES treatment induced persistent and epithelial cell specific imbalances in the estrogen regulated uterine expression of c jun , c fos , c myc , bax , bcl 2 , and bcl 10 proto oncogenes . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Selective induction of apoptosis in cancer cells by the ether lipid ET 18 OCH 3 ( Edelfosine ) : molecular structure requirements , cellular uptake , and protection by Bcl 2 and Bcl 10 ( L ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The Bcl 2 and Bcl 10 proteins suppress programmed cell death , whereas Bax promotes apoptosis . ^^^ We investigated the pattern of expression of Bcl 2 , Bax and Bcl 10 during neuronal differentiation and development . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Experiments using transgenic and gene knockout mice have revealed much about the roles played by Bcl 2 , Bcl 10 and Bax in regulating apoptosis in the immune system . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 , Bcl 10 ( L ) , and Bax are members of the Bcl 2 family that play key roles in the regulation of apoptosis . ^^^ Herein we report that in murine thymocytes , Bcl 2 is exclusively membrane bound , whereas Bax is present predominantly in the cytosol and Bcl 10 ( L ) is present in both soluble and membrane bound forms . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Differential expression of bcl 2 and bcl 10 during chicken spermatogenesis . ^^^ We report the isolation and characterization of a chicken testis bcl XL cDNA coding for a long bcl 10 protein with a hydrophobic tail , and the expression of bcl 2 and bcl 10 during chicken spermatogenesis . ^^^ Differential expression of bcl 2 and bcl 10 during spermatogenesis is consistent with the reported different susceptibility to apoptosis of spermatogonia , and meiotic and postmeiotic cells . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
As the low level of bcl 2 and bax mRNA was not influenced by progesterone treatment , the observed changes in total amount of bcl 10 transcripts and spliced isoforms could represent the mechanism by which progesterone controls cell death in epithelial cells of the endometrium . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Ten erythema multiforme and five control oral mucosa biopsy specimens were evaluated in immunohistochemically stained sections for apoptosis regulating proteins Bcl 2 , Bcl 10 , Bax , p 53 , Fas , and Fas ligand . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 and its homologues , bcl 10 and bax , also increase in amount with bcl 2 and bcl 10 increasing more rapidly than bax . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Identification of a novel regulatory domain in Bcl 10 ( L ) and Bcl 2 . ^^^ Bcl 10 ( L ) , a member of the Bcl 2 family , can inhibit many forms of programed cell death . ^^^ Compared with the full length protein , loop deletion mutants of Bcl 10 ( L ) and Bcl 2 displayed an enhanced ability to inhibit apoptosis . ^^^ These results suggest that the loop domain in Bcl 10 ( L ) and Bcl 2 can suppress the anti apoptotic function of these genes and may be a target for regulatory post translational modifications . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 and Bcl 10 ( L ) . ^^^ The product of harakiri , Hrk , physically interacts with the death repressor proteins Bcl 2 and Bcl 10 ( L ) , but not with death promoting homologs , Bax or Bak . ^^^ Expression of Hrk induces cell death which is inhibited by Bcl 2 and Bcl 10 ( L ) . ^^^ Deletion of 16 amino acids including the conserved BH 3 region abolished the ability of Hrk to interact with Bcl 2 and Bcl 10 ( L ) in mammalian cells . ^^^ Moreover , the killing activity of this mutant form of Hrk ( Hrk deltaBH 3 ) was eliminated or dramatically reduced , suggesting that Hrk activates cell death at least in part by interacting with and inhibiting the protection afforded by Bcl 2 and Bcl 10 ( L ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Western blot and PCR analysis did not show consistent differences between cell lines examined in the expression of Bcl 2 , Bcl 10 ( L ) , Bcl 10 ( S ) , and Bak . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In this study , we examined the sphingosine induced apoptosis of the androgen independent human prostatic carcinoma cell line DU 145 , which expresses bcl 10 ( L ) and Bax but not bcl 2 , and found that treatment of DU 145 cells with sphingosine suppressed bcl 10 ( L ) in both mRNA and protein levels but did not change bax expression at all . ^^^ Our present results , together with previous observations , strongly suggest that apoptosis regulatory genes differ according to cell type and apoptosis induction through sphingosine is accompanied by inhibition of either bcl 2 or bcl 10 ( L ) activity in these cells . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
CD 437 downregulates the expression of a number of proteins which antagonize apoptosis . bcl 10 ( L ) , a homologue of bcl 2 , antagonizes apoptosis , while bcl 10 ( S ) enhances apoptosis . ^^^ We have found that estrogen receptor ( ER ) negative HBCs express higher levels of bcl 10 ( L ) and significantly lower levels of bcl 2 than their ER positive counterparts . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The bcl 10 gene , a bcl 2 family member , is highly regulated during lymphoid development , and its expression modulates apoptosis in lymphoid and other cell populations . ^^^ The remarkable similarity between the genomic regions of bcl 2 and bcl 10 suggests that these genes have evolved from a common ancestral gene or through gene duplication . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
IGF induced protection against dexamethasone was not associated with any alteration in quantitative or qualitative expression of BCL 2 , BAX or BCL 10 proteins . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Presence of mRNA of several genes involved in the apoptotic process , i . e . , Bcl 2 , Bcl 10 , ICE , Ich 1 , and DAD 1 , was studied in response to normal and CS media . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We have evaluated the roles of the apoptosis protective proteins Bcl 2 and Bcl 10 in stimulated PBMC from asymptomatic HIV infected and HIV uninfected individuals . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 , Bcl 10 , Bax and p 53 apoptosis associated proteins were evaluated in immunohistochemically stained tissue sections according to staining intensity and pattern . ^^^ RESULTS : Generally , there were only slight differences in the expression of Bcl 2 and Bcl 10 proteins in the epithelium of HL and control tissue . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Expression of Bcl 2 family during liver regeneration and identification of Bcl 10 as a delayed early response gene . ^^^ Induction of Bcl 2 and Bcl 10 has been demonstrated in mitogen stimulated lymphocytes in vitro , suggesting that these two apoptosis modulators may also play a role during proliferation . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Using western blotting and immunochemical analysis , we investigated alterations in the expression of the apoptosis related proteins bcl 2 , bax , and bcl 10 in colonic adenocarcinomas induced by subcutaneous injection of azoxymethane ( AOM ) ( 15 mg / kg body weight weekly for 2 wk ) into male Sprague Dawley rats . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
To investigate the dual effects ( proliferation and apoptosis ) of IL 10 on B cells , the expression of a panel of bcl 2 protoncogene family members , bcl 2 , bcl 10 , mcl 1 , and bax , was analyzed when B cells were activated by SAC . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Preablation biopsy specimens and prostatectomy specimens were immunohistochemically stained for apoptotic cells and for expression of apoptosis regulatory proteins Bcl 2 , Bax , Bcl 10 , and Bak . ^^^ In all 26 specimens , benign prostatic hyperplasia demonstrated increased expression of the Bcl 2 protein , but no change in the expression of Bax , Bcl 10 , and Bak . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Cells growing attached to flasks appear to be relatively more resistant than suspension growing cells in spite of endogenous bcl 2 , bax , or bcl 10 levels . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Apoptosis of human myeloid leukemia cells induced by an inhibitor of protein phosphatases ( okadaic acid ) is prevented by Bcl 2 and Bcl 10 ( L ) . ^^^ HL 60 cells express Bcl 2 and little or no Bcl 10 ( L ) , while K 562 expresses Bcl 10 ( L ) but not Bcl 2 . ^^^ Since phosphorylation / dephosphorylation reactions have been suggested to be involved in the regulation of Bcl 2 , we planned to investigate whether the expression of Bcl 2 , Bcl 10 ( L ) and Bax , a protein that antagonizes the antiapoptotic function of Bcl 2 , are regulated in myeloid leukemia cell lines ( K 562 , KU 812 and HL 60 ) treated with okadaic acid . ^^^ Our results indicate that exposure of all three leukemic cell lines to nanomolar concentrations of okadaic acid causes a loss of viability by activation of an apoptotic process accompanied by a marked decrease in the expression of Bcl 2 , Bcl 10 ( L ) and Bax at both mRNA and protein level , but not of c fos , vimentin and epsilon globin , ruling out a non specific effect of okadaic acid . ^^^ Furthermore , constitutive expression of either Bcl 10 ( L ) or Bcl 2 by gene transfer inhibited apoptosis triggered by okadaic acid in K 562 cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
As bcl 10 ( L ) is a bcl 2 related gene with anti apoptotic activity which also confers resistance to cytotoxic drugs we have studied its expression in AML in relation to cellular growth characteristics and to the expression of P glycoprotein . ^^^ These results provide a further explanation for the poor prognosis associated with autonomous in vitro growth of AML blasts and illustrate that these cells may coexpress different modalities of resistance to cytotoxic drug therapy involving both anti apoptotic pathways ( bcl 10 ( L ) , bcl 2 ) and classic multidrug resistance ( MDR 1 ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The proto oncogene bcl 2 and a bcl 2 related gene bcl 10 prevent apoptotic cell death induced by various treatments . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The available data also indicate that bcl 10 and bcl 2 are expressed in reciprocal patterns during the lifespan of a lymphocyte , suggesting unique regulatory roles for these two survival proteins . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
To further understand the underlying mechanism ( s ) for these findings as they relate to gene directed neural cell death , we studied the in situ expression of the Bcl 2 family of proteins , including the pro apoptosis gene product Bax , the anti apoptosis gene product Bcl 2 , and Bcl 10 . ^^^ In contrast , patients with HIVE , but not HIV 1 without encephalitis , or seronegative controls , had increased expression of Bcl 2 and Bcl 10 in reactive astrocytes in cortex and basal ganglia . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Expression of Bcl 10 ( an antiapoptotic Bcl 2 family protein ) was not altered by bile duct ligation , whereas expression of Bax ( a proapoptotic Bcl 2 family protein ) increased slightly as determined by Northern and Western blot analyses . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Elevated expression of Bcl 2 and Bcl 10 by intestinal intraepithelial lymphocytes : resistance to apoptosis by glucocorticoids and irradiation . ^^^ Also , the high levels of Bcl 2 and Bcl 10 in this in vivo activated population supports the in vitro correlate of protection from activation induced cell death . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
High levels of the antiapoptotic Bcl 10 ( L ) or Bcl 2 , relative to the proapoptotic Bax , have been shown to inhibit HIDAC induced cleavage and activity of caspase 3 and apoptosis of the human acute myeloid leukemia HL 60 cells . ^^^ HIDAC treatment for 4 h also modestly increased the intracellular levels of free Bax relative to Bax bound to Bcl 2 and Bcl 10 ( L ) in HL 60 / neo but not in HL 60 / Bcl 10 ( L ) cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
To better understand the regulation of apoptosis in this paradigm of endocrine regulated cell turnover , we studied the expression of the cell death regulatory genes , bax , bcl 2 , and bcl 10 , in human proliferative and secretory endometria relative to the absence or presence of apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The BCL 2 gene and its family member BCL 10 as well as the TP 53 genes regulate apoptosis and have been shown to have a direct effect on the sensitivity of cancer cells to radiation and chemotherapeutic agents . ^^^ METHODS : The expression of BCL 10 , a BCL 2 related protein that is a potent inhibitor of apoptosis , was investigated by immunohistochemical and immunoblot methods in 43 primary untreated breast carcinomas , in conjunction with BCL 2 and TP 53 . ^^^ In contrast to BCL 2 expression , up regulation of BCL 10 protein may be a marker of tumor progression . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
At the end of embryonic development expression of bcl 10 ( L ) , bcl w , and bcl 2 is down regulated in parallel to massive apoptotic death of collecting duct and distal tubular epithelia . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
After exposure to soluble CD 95 ligand , Jurkat T cells , but not Ag specific T cells , exhibit loss of BCL 2 and BCL 10 expression whereas BAX expression is not affected . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In addition , we examined expression patterns of the anti apoptotic proteins Bcl 2 and Bcl 10 and the cell death promoting protein Bax in retinae after crushing the optic nerve . ^^^ Bcl 2 and Bcl 10 proteins were expressed in ganglion cells at low levels . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
While the repression of 5 Rel was accompanied by the rapid degradation of IkappaBalpha , changes in the steady state levels of the apoptosis inhibitors Bcl 2 and Bcl 10 ( L ) were only observed following the onset of cell death in transformed lymphoid cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Evidence suggests that these proteases act downstream of inhibitors of PCD such as Bcl 2 and Bcl 10 ( L ) , which are frequently expressed in Reed Sternberg ( RS ) cells of Hodgkin ' s disease ( HD ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
B cell receptor cross linking prevents Fas induced cell death by inactivating the IL 1 beta converting enzyme protease and regulating Bcl 2 / Bcl 10 expression . ^^^ In this system , Fas ligation also triggers Bcl 2 / Bcl 10 down regulation , an effect inhibited by sIgG cross linking , the cysteine protease inhibitor acetyl Tyr Val Ala Asp chloromethyl ketone , and PMA treatment . ^^^ In A 20 cells , Fas signaling may thus trigger both ICE activation and Bcl 10 and Bcl 2 down regulation . ^^^ These results indicate that sIgG signaling gives rise to two pathways after PKC activation , one presumably promoted by non PMA sensitive PKC , which inactivates the ICE cascade , and another produced by PMA sensitive PKC , which maintains normal Bcl 2 / Bcl 10 levels . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Expression of Apo 1 / Fas ( CD 95 ) , Bcl 2 , Bax and Bcl 10 in myeloma cell lines : relationship between responsiveness to anti Fas mab and p 53 functional status . ^^^ We studied eight myeloma cell lines for the presence of Bcl 2 , which inhibits apoptosis , of Bax , which counteracts Bcl 2 , of Bcl 10 ( L ) and Bcl 10 ( S ) , which act in an anti and pro apoptotic fashion , respectively , and of Apo 1 / Fas , which induces programmed cell death , when activated by the Apo 1 / Fas ligand or the relevant monoclonal antibody ( mab ) . ^^^ All cell lines constitutively expressed homogenous amounts of Bcl 2 , but displayed different amounts of Bax and Bcl 10 proteins . ^^^ The relative expression levels of Apo 1 / Fas correlated with that of Bax , but not with that of Bcl 2 or Bcl 10 subtypes . ^^^ Furthermore , the effectiveness of the Apo 1 / Fas mab was associated with the relative expression levels of the Apo 1 / Fas and with that of the Bax antigen , but not with that of the Bcl 2 and Bcl 10 antigens . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 , Bcl 10 long , and Bax protein expression were evaluated by immunoblot analysis , and Bcl 2 expression was modulated using antisense technology . ^^^ Although expression of Bcl 10 long and Bax protein were similiar in the two cell lines , Bcl 2 protein expression was 15 fold greater in malignant than in nonmalignant cholangiocytes . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The expression of several other bcl 2 family members ( bcl 10 , ich 1 , bax , bag , and bak ) and retinoid receptors ( RARalpha , RXRalpha , and RXRbeta ) was not affected by treatment with RAR and / or RXR activating retinoids ; RARbeta RNA was undetectable before and after retinoid treatment . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Several of these genes , including bcl 2 , bcl 10 , and bax , share homology at the amino acid level in the BH 1 and BH 2 domains , through which they also interact . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The pattern of endogenous expression levels of Bax , Bcl 2 , Bcl 10 and Bak , which was not modulated by cisplatin treatment , demonstrated that these Bcl 2 family proteins are not involved in drug induced apoptosis in the TGCT cell lines . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Here , we demonstrate that expression of galectin 3 in human breast carcinoma BT 549 cells inhibits cis diamminedichloroplatinum ( cisplatin ) induced poly ( ADP ribose ) polymerase degradation and apoptosis , without altering Bcl 2 , Bcl 10 ( L ) , or Bax expressions . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Here we demonstrate that , in addition to the previously identified A 1 , four other members of the Bcl 2 family , Bcl 2 , Mcl 1 , Bcl 10 ( L ) , and Bax , are expressed in endothelial cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The BAD protein is a pro apoptotic member of the Bcl 2 family whose ability to heterodimerize with survival proteins such as Bcl 10 ( L ) and to promote cell death is inhibited by phosphorylation . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Similarly , the Bcl 2 family member , Bcl 10 ( L ) also blocked staurosporine induced cell death in MN9D cells whereas overexpression of Bcl 10 ( S ) or Bax did not . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We have selected bcl 10 gene expression for study because there is increasing evidence that proteins encoded by the bcl 2 gene family ( bcl 2 , bcl 10 , bax etc ) play a role in the regulation of programmed cell death . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
This line , which expresses p glycoprotein and serves as a model of multidrug resistance in multiple myeloma cells , demonstrated an up regulated expression of BCL 10 L , which was relatively specific , in that BCL 2 or BAX expression was not altered . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Additionally , PGE 2 inhibits programmed cell death caused by SC 58125 and induces Bcl 2 expression , but did not affect Bcl 10 or Bax expression in human colon cancer ( HCA 7 ) cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 , Bax and Bcl 10 expression following hypoxia ischemia in the infant rat brain . ^^^ Expression of Bcl 2 , Bax and Bcl 10 was examined in control and hypoxic ischemic rats using immunohistochemistry and Western blotting . ^^^ Bcl 2 , Bax and Bcl 10 immunoreactivity decreased in necrotic cells , but about 60 % of cells with apoptotic like morphology and cells with granular chromatin degeneration were stained with antibodies to Bcl 2 , Bax or Bcl 10 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In this study we investigated what effect the differentiation agent butyrate had on the cellular levels of the apoptosis regulators BCL 2 , BCLX ( L ) and BAX and on radiation induced apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Differential regulation of Bax , Bcl 2 , and Bcl 10 proteins in focal cortical ischemia in the rat . ^^^ At all time points examined , Bcl 2 and Bcl 10 protein levels were markedly reduced in injured neurons as compared to the unlesioned side . ^^^ In contrast , large , morphologically intact neurons located more towards the healthy brain parenchyma displayed an increase in cytoplasmic Bcl 2 and Bcl 10 proteins . ^^^ Double staining for each of the Bcl 2 family proteins and TUNEL revealed that DNA strand breaks and nuclear fragmentation seen in cells located in the lesion core were often associated with increased levels of Bax , but not with elevated Bcl 2 or Bcl 10 protein levels , suggesting a role for Bax in the induction of apoptotic death in these cells . ^^^ The upregulation of Bcl 2 and Bcl 10 expression in surviving neurons close to the penumbra might reflect an active survival mechanism that protects these neurons from cell death following a sublethal insult . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Relationship between nitrogen mustard drug resistance in B cell chronic lymphocytic leukemia ( B CLL ) and protein expression of Bcl 2 , Bax , Bcl 10 and p 53 . ^^^ Several genes have been implicated in the regulation of apoptosis including bcl 2 , bax , bcl 10 and p 53 . ^^^ Using Western blot analysis , we examined the levels of Bcl 2 , Bax , Bcl 10 and p 53 protein expression and determined whether the levels of these proteins correlated with in vitro drug resistance in CLL patients ' lymphocyte samples . ^^^ Our investigations suggest that in CLL , NM drug resistance develops without any detectable alteration of Bcl 2 , Bax or Bcl 10 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In the centre of the lesion , Bax protein increased and Bcl 2 and Bcl 10 proteins decreased after loss of microtubule associated protein 2 antigenicity occurred , but at the border of the lesion , the former changes preceded loss of microtubule associated protein 2 antigenicity . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We studied the expression of three members of the Bcl 2 protein family , Bcl 2 , Bcl 10 , and Bax , in a selection of senile and DS related AD patients as well as in controls . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
BH 4 of Bcl 2 could be replaced by that of Bcl 10 without perturbing function but not by a somewhat similar region near the N terminus of Bax . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The anti apoptotic proteins Bcl 2 , Bcl 10 ( L ) , Mcl 1 , and BAG 1 were present at immunodetectable levels in 7 , 10 , 10 , and 9 of the 11 lines . ^^^ Comparing these 11 cell lines among themselves revealed that steady state levels of Bcl 2 , Bcl 10 ( L ) , Mcl 1 , and BAG 1 were present at relatively higher levels in 4 , 6 , 5 , and 5 of the lines , respectively . ^^^ Immunoblot analysis of primary adenocarcinomas revealed expression of the anti apoptotic proteins Bcl 2 , Bcl 10 ( L ) , Mcl 1 , and BAG 1 , as well as the pro apoptotic proteins Bax , Bak , and CPP 32 , in at least 2 of the 3 tumors examined . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Differentiation and lineage related differences in the expression of two anti apoptotic molecules , bcl 10 and bcl 2 , were examined using various human hematopoietic cell lines . ^^^ On the other hand , bcl 10 was not expressed in more mature myeloid cell lines ( HL 60 and PL 21 ) , but bcl 2 was strongly expressed in these cells and in monocytoid cell lines ( U 937 , THP 1 , and JOSK 1 ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Alteration of proteins regulating apoptosis , Bcl 2 , Bcl 10 , Bax , Bak , Bad , ICH 1 and CPP 32 , in Alzheimer ' s disease . ^^^ Apoptosis is regulated by the B cell leukemia 2 gene product ( Bcl 2 ) family ( Bcl 2 , Bcl 10 , Bax , Bak and Bad ) and the caspase family ( ICH 1 and CPP 32 ) , with apoptosis being prevented by Bcl 2 and Bcl 10 , and promoted by Bax , Bak , Bad , ICH 1 and CPP 32 . ^^^ In the membranous fraction , the levels of Bcl 2 alpha , Bcl xL , Bcl 10 beta , Bak and Bad were increased in AD . ^^^ These findings demonstrate a differential involvement of cell death regulatory proteins in AD and suggest that Bak , Bad , Bcl 2 and Bcl 10 are upregulated in AD brains . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Expression of bcl 2 and bcl 10 in bladder cancer . ^^^ Overexpression of the bcl 2 and bcl 10 anti apoptotic genes has been correlated with poor prognosis and chemotherapy resistance in other systems . ^^^ We thus sought to determine expression of bcl 2 and bcl 10 in TCC and correlate these with stage , survival and abnormal pRb or p 53 expression . ^^^ Immunohistochemistry for p 53 , pRb , bcl 2 and bcl 10 was performed on an automated system using indirect streptavidin biotin / horseradish peroxidase staining . ^^^ RESULTS : Bcl 2 was expressed in less than 1 % of normal urothelial cells , but moderate expression of bcl 10 was found in all normal urothelial samples . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Developmental patterns of BCL 2 and BCL 10 polypeptide expression in the human spinal cord . ^^^ The cell death suppressors bcl 2 and bcl 10 are developmentally regulated and may modulate physiologic cell death in the central nervous system ( CNS ) . ^^^ We examined the ontogeny of bcl 2 and bcl 10 in 12 human spinal cords of gestational ages ( GA ) between 5 and 39 weeks and in 3 adult cords . ^^^ These findings suggest that bcl 2 and bcl 10 may both be required for survival of early postmitotic neurons before appropriate synaptic connections have been established . ^^^ Continued neuronal survival ( after bcl 2 is down regulated ) may require persistent bcl 10 expression in addition to target derived neurotrophic factors made available through the formation of appropriate synapses . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Diminished susceptibility to chemotherapy has also been attributed , in in vitro systems , to alterations in the levels of bcl 2 , bax , or bcl 10 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Recombinant Bcl 2 or Bcl 10 ( L ) proteins augment the resistance of reconstituted PT pore complexes to pore opening induced by t BHP . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
A comparative examination of HVS transformed T cell clones and their native parental clones revealed that the expression of Bcl 2 , Bcl 10 ( L ) , Bax , and members of the tumor necrosis factor receptor ( TNF R ) superfamily with a death domain , namely , TNF RI , CD 95 , and TRAMP , were not modulated by HVS . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Throughout the course of the disease , which peaked 12 14 days after inoculation and was followed by clinical recovery , we analyzed the DNA content of the spinal cord inflammatory cells to assess apoptosis and , simultaneously , we measured the expression of five proteins ( Fas , Fas ligand ( Fas L ) , Bcl 2 , Bcl 10 and Bax ) which modulate the apoptotic process . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Sensitive S 49 cells and resistant variants did not differ in the expression levels of the apoptosis regulating genes bax , bad , bcl 10 and bcl 2 , the status of the p 53 gene nor in a different requirement for the growth factors 2 2 , IL 4 or IL 9 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Expression of Bcl 10 ( L ) , an antiapoptotic member of the Bcl 2 family , in esophageal squamous cell carcinoma . ^^^ Bcl 10 , a Bcl 2 related protein , is a potent antagonist of apoptosis in its long splice variant ( Bcl 10 ( L ) ) . ^^^ In invasive carcinomas , Bcl 10 ( L ) expression decreased continuously with decreasing tumor differentiation ( P = 0 . 0001 ) and was also directly correlated with bcl 2 associated 10 protein expression ( P = 0 . 0001 ) . ^^^ On the contrary , an inverse correlation was found between Bcl 10 ( L ) expression and Bcl 2 protein expression ( P = 0 . 0001 ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We investigated apoptotic cell death in the cerebellum of five cases of XP group A ( XPA ) , four cases of CS , and twelve controls , using TdT mediated DIG dUTP nick end labeling ( TUNEL ) and immunohistochemical staining for bcl 2 , bcl 10 , p 53 , bax , BDNF and Trk B . ^^^ Upregulation of bcl 2 or BDNF was not observed , and bcl 10 expression was not altered . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Here we have examined the expression of several proteins involved in the susceptibility to apoptosis in 20 human gliomas , including the BCL 2 family proteins BCL 2 , BCL 10 , BAX and MCL 1 , as well as p 53 and RB . ^^^ There was good correlation between expression of the functional antagonists , BCL 2 / BCL 10 and BAX , suggesting that changes in the BCL 2+BCL X / BAX ratio are not responsible for the differential response of glioma patients to chemotherapy . ^^^ There was no prominent association of outcome with the expression patterns of p 53 , RB , BCL 2 , BCL 10 or BAX . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The identity of the insert of each clone was determined by slotblots of the DNA amplified from individual colonies and by hybridization with radioactive probes specific to the bcl 2 , bcl 10 , or bax genes . ^^^ RESULTS : We found that bcl 2 is the predominant member expressed in AML samples with a poor prognosis ( 5 , 7 ) , whereas the transcripts of bcl 10 are higher than those of bcl 2 in the AML samples with a good prognosis [ inv 16 , t ( 8 ; 21 ) ] . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In addition , the expression of Bax , Bcl 2 , Bcl 10 ( L ) , and p 53 messenger RNA ( mRNA ) was analyzed by in situ hybridization . ^^^ The mRNAs for Bax and p 53 also were increased , whereas no changes were detected in Bcl 2 and Bcl 10 ( L ) mRNA levels . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Baseline levels of message were detected for 3 ced 3 ( CPP 32 , Ich 1 and ICE ) and 4 ced 9 homologs ( bcl 10 , MCL 1 , bcl 2 and bax ) in the frontal cortex . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The position of a single intron was conserved in comparison to other members of the Bcl 2 family , namely Bax , CED 9 , Bcl 10 and Bcl 2 , but all other introns were displaced , consistent with a divergent phylogeny . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Expression of the death related proteins ( DRPs ) Bcl 2 , Bax , Bcl 10 and Bak that regulate cell survival and death was examined using immuno histochemical methods in a group of 142 T 1 ( < 2 cm ) ductal breast carcinomas . ^^^ Expression of anti apoptotic proteins Bcl 2 and Bcl 10 was found in 57 . 0 % and 62 . 75 % of tumors , respectively . ^^^ Bcl 2 expression , but not Bcl 10 expression , was related to loss of apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Semi quantitative RT PCR revealed that expression of c myc and bcl 2 genes was reduced during the apoptotic process , while expression of bax and bcl 10 ( L ) genes was not changed . ^^^ Forced expression of the c myc , bcl 2 and bcl 10 ( L ) genes protected MEL cells from apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Expression of the Bcl 2 family of apoptosis related genes ( bcl 2 , bcl 10 , mcl 1 , and bax ) and the proliferation and apoptosis related genes p 53 and cyclin D 1 were determined in 40 low T stage laryngeal carcinomas and in uvular epithelium from patients without SCC . ^^^ Among the antiapoptotic members of the Bcl 2 family , Bcl 10 and Mcl 1 showed more intense and widespread staining than Bcl 2 itself in both normal squamous mucosa and SCC . ^^^ Bcl 10 and Mcl 1 appear to be the most abundantly expressed antiapoptotic proteins of the Bcl 2 family in both normal squamous mucosa and SCC of the larynx . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Expression of p 53 , p21 / WAF / CIP , Bcl 2 , Bax , Bcl 10 , and Bak in radiation induced apoptosis in testicular germ cell tumor lines . ^^^ Expression of p21 / WAF / CIP was determined by Northern blot analysis and immunoblotting was used to monitor p 53 , Bax , Bcl 2 , Bcl 10 , and Bak protein levels . ^^^ Constitutive expression of Bax , Bcl 2 , Bcl 10 , and Bak was not affected by radiation and showed no correlation with cell susceptibility to radiation induced apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The BCL 10 gene belongs to the family of BCL 2 homologues and plays an important role in the regulation of programmed cell death ( PCD ) in normal lymphoid tissues . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
To examine which proteins are involved in this apoptosis , we examined changes in protein levels of the Bcl 2 family , including Bcl 2 , Bcl 10 and Bax . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Variable levels of bcl 2 , bcl 10 and bax mRNA in bladder cancer progression . ^^^ We investigated the expression of the anti apoptotic genes bcl 2 and bcl 10 and the pro apoptotic gene bax in bladder tumors and normal samples from urinary bladder , using RT PCR analysis . ^^^ Bcl 10 gene expression was quite variable among all samples ( 37 % in normal tissues , 50 % in the low stage tumors and 14 % in the high stage ) . bcl 10 mRNA was only found in the isoform bcl XL , with anti apoptotic functions , whereas no sample expressed the isoform bcl XS , which is known to suppress bcl 2 functions . ^^^ Most samples expressing bcl 2 did not express bcl 10 , and vice versa . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The IL 7 trophic affect correlated with increased intracellular levels of Bcl 2 and decreased levels of Bax , whereas no Bcl 10 ( L ) , Bcl w , or Bad was detectable . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Immunohistochemical analysis of bcl 2 , bax , mcl 1 , and bcl 10 expression in ovarian surface epithelial tumors . ^^^ The expression of bcl 2 family proteins was investigated in 28 ovarian surface epithelial tumors , including serous and mucinous benign , borderline , and malignant tumors by immunohistochemical staining with antibodies to bcl 2 , bax , bcl 10 , and mcl 1 proteins . ^^^ Significantly less immunoreactive bcl 2 and bcl 10 proteins were present in malignant serous tumors compared to their benign counterparts . ^^^ The loss of expression of the antiapoptotic proto oncogenes bcl 2 or bcl 10 in serous carcinomas compared to benign serous tumors , together with previous demonstrations that the presence of bcl 2 in ovarian surface epithelial cancers is a favorable prognostic indicator , suggests that bcl 2 and bcl 10 have biological functions in the ovary other than inducing apoptosis , acting instead as tumor suppressor proteins . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We tested the role of bcl 2 by transfecting 2 low bcl 2 expressing myeloma cell lines , ARP 1 and 8226 , with a bcl 2 expression vector and compared the effects of DEX and MEL on apoptosis , cell cycle distribution and the levels of proapoptotic ( bax ) and antiapoptotic ( bcl 2 , bclx ) proteins . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
To examine whether the altered sensitivity to this apoptotic signal was correlated with the expression of proteins of the bcl 2 family , the expression of bcl 2 , bcl 10 , and bax proteins was determined . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 , Bax , and Bcl 10 expression in the CA 1 area of the hippocampus following transient forebrain ischemia in the adult gerbil . ^^^ Immunohistochemistry and Western blotting to Bcl 2 , Bax , and Bcl 10 was examined in control ( age matched , non operated and sham operated ) and ischemic gerbils . ^^^ Strong Bcl 2 and Bcl 10 immunoreactivity was found in CA 1 neurons following ischemia . ^^^ Bcl 2 , Bax , and Bcl 10 were localized in dying cells , thus suggesting that expression of Bcl 2 was not sufficient to prevent nerve cells from dying . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Quantitative Western blotting was used to examine the protein expression of P 53 and P21WAF 1 , Bcl 2 and Bcl 10 ( L ) ( anti apoptotic proteins ) , and Bax , Bak , and Bad ( proapoptotic proteins ) . ^^^ Upon deprivation , these cancer cells up regulated P 21 and Bcl 2 and / or BclX ( L ) , lost response to withdrawal induced up regulation of Bax / Bad / Bak or decreased or even completely lost Bax expression and expressed some novel proteins such as P 25 and P54 / 55 complex . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We used immunoblots to estimate levels of Bcl 2 , Bcl 10 ( l ) , and Bax at various times after carotid occlusion . ^^^ Rather than Bcl 2 , Bcl 10 ( l ) appears to be the predominant neuroprotective form of this family of proto oncogenes in the gerbil hippocampus . ^^^ After transient ischemia , Bcl 2 and Bcl 10 ( l ) protein levels remained the same . ^^^ Therefore , Bax may disrupt the more favorable Bcl 10 ( l ) ( Bcl 2 ) interactions necessary for normal neuronal functioning and thus promote transient ischemic death . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The bcl 2 gene was expressed in 54 % of the tumors ( 19 / 35 ) , whereas bcl 10 and bax gene products were present in only a low fraction of these lymphomas ( 4 / 35 ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
During the process of terminal differentiation toward mature neutrophils , the anti apoptotic proteins Bcl 2 and Bcl 10 become down regulated and eventually cease to be expressed , whereas the death promoting Bcl 2 homologue , Bax , persists . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
To investigate the molecular mechanism of glandular parenchyma destruction in Sjgren ' s syndrome ( SS ) , Bcl 2 , Bax , Bcl 10 , and Bak expression were studied . ^^^ Both SS and control salivary gland ductal epithelial cells expressed Bcl 2 , Bax , and Bcl 10 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We examined the expression of Bax , Bcl 2 , Bcl 10 , and Mcl 1 in human benign nevi , primary MM , and metastatic MM using immunohistochemistry . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Formalin fixed tissue sections were immunohistochemically stained for apoptosis associated proteins ( Bcl 2 , Bcl 10 , Bax , Bak , p 53 , MDM 2 , BHRF ) . ^^^ The irregular expression of Bcl 2 , Bcl 10 , Bax , and Bak in oral lymphomas indicates dysfunctional apoptotic mechanisms in these tumors . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We analyzed the expression of bcl 2 and bcl 10 proteins in hematopoietic precursors obtained from various cell sources in adult mobilized peripheral blood collected from 13 patients with solid tumors , 8 adult bone marrow , and 12 umbilical cord blood . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We did not observe any changes in Bcl 2 or Bcl 2 related proteins ( Bcl 10 , Bax , and Bad ) in control or KCREB transfected cells before or after treatment with Tg . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
To elucidate molecular events in the apoptosis , expressions of Bcl 2 protein family members , such as Bcl 2 , Bcl 10 and Bax , and heat shock protein 70 ( HSP 70 ) were measured by western blotting using specific antibodies . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 and Bcl 10 ( L ) protected control cells against apoptosis after either IL 3 withdrawal or drug exposure , although in some cases this effect could be overridden by myc oncoproteins , particularly N myc and L myc . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 , Bax and Bcl 10 expression in neuronal apoptosis : a study of mutant weaver and lurcher mice . ^^^ We investigated the expression of the apoptosis modulating proteins Bcl 2 , Bax and Bcl 10 in the cerebellum of mutant lurcher and weaver mice . ^^^ The observed expression patterns of Bcl 2 , Bax and Bcl 10 protein in apoptotic lurcher and weaver neurons support the hypothesis that the execution of neuronal apoptosis involves increased expression of Bax , which could represent a general mechanism in diverse neurodegenerative processes . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
METHODS AND RESULTS : The in situ end labelling technique ( ISEL ) was used to determine apoptotic cells , in addition to immunohistochemical methods , which were used to investigate the expression of the Ki 67 antigen ( avidinbiotin complex ( ABC ) method ) and bcl 2 , bcl 10 , p 53 , p21 / waf1 , p 27 and mdm 2 proteins ( catalysed reporter deposition ( CARD ) technique ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We investigated the sequence of these events in SHEP neuroblastoma cells transfected with Bcl 2 or Bcl 10 ( L ) using two different drugs , namely , doxorubicin ( Doxo ) , which activates the CD95 / CD95 ligand ( CD 95 L ) system , and betulinic acid ( Bet A ) , which does not enhance the expression of CD 95 or CD 95 L and which , as shown here , directly targets mitochondria . ^^^ Apoptosis induced by both drugs was inhibited by Bcl 2 or Bcl 10 ( L ) overexpression or by bongkrekic acid , an agent that stabilizes mitochondrial membrane barrier function , suggesting a critical role for mitochondria . ^^^ After Doxo treatment , enhanced CD95 / CD95 L expression and caspase 8 activation were not blocked by Bcl 2 or Bcl 10 ( L ) and were found in cells with a mitochondrial transmembrane potential ( delta psi ( m ) ) that was still normal ( delta psi ( m ) high cells ) . ^^^ In marked contrast , after Bet A treatment , caspase 8 activation occurred in a Bcl 2 or Bcl 10 ( L ) inhibitable fashion and was confined to cells that had lost their delta psi ( m ) ( delta psi ( m ) low cells ) . ^^^ In contrast to caspase 8 , cleavage of caspase 3 or poly ( ADP ribose ) polymerase was always restricted to delta psi ( m ) low cells , downstream of the Bcl 2 or Bcl 10 ( L ) controlled checkpoint of apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Twenty archival paraffin embedded keloid samples were randomly selected for an immunoperoxidase assay with antibodies against fas , p 53 , bcl 2 , and bcl 10 proteins using the target antigen retrieval technique . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The drug resistant line has a particular pattern of the expression of bcl 2 family members : bcl 2 protein and message were expressed to a similar extent , however , compared with the parent line , the message for bclx short was decreased . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 , Bcl 10 ( L ) , Bax , Bad , Bak and p 53 protein expression was analysed by Western blotting . ^^^ Analysis of the steady state levels of Bcl 2 family proteins showed high expression of Bcl 10 ( L ) in all of the cell lines except Colo 320 . ^^^ There was a significant correlation between chemosensitivity and Bcl 10 ( L ) to Bax ratio , rather than Bcl 2 to Bax . ^^^ In conclusion , these results suggest that some members of the Bcl 2 family of proteins , in human colon cancer cell lines , are modulated by 5 FU and that the ratio of Bcl 10 ( L ) to Bax may be related to chemosensitivity to 5 FU . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The IL 2 receptor promotes proliferation , bcl 2 and bcl 10 induction , but not cell viability through the adapter molecule Shc . ^^^ We found that at least one of these tyrosines ( Y 338 ) also mediates cell survival and induction of bcl 2 , bcl 10 , and c myc in the murine T cell line CTLL 2 . ^^^ This Shc mediated signal induced expression of c myc as well as the antiapoptotic genes bcl 2 and bcl 10 with normal magnitude and kinetics . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Decreased expression of bcl 2 and bcl 10 mRNA coincides with apoptosis following intracerebral administration of 3 nitropropionic acid . ^^^ We injected 3 NP into the striatum of rats to examine the potential role of Bcl 2 or Bcl 10 , proteins that can inhibit apoptosis , in brain injury due to 3 NP . ^^^ Expression of bcl 2 , bcl 10 , and c jun mRNA expression was evaluated 1 , 3 , 6 , and 12 h and 1 , 3 , 5 , and 7 days after injection using in situ hybridization . ^^^ Both bcl 2 and bcl 10 mRNA expression in the striatum decreased starting at 6 h and continued to 5 days after injection . ^^^ The similarity in the time course of apoptosis to that of suppression of bcl 2 and bcl 10 mRNA suggests that changes in expression of these genes may contribute to apoptosis following 3 NP injection . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Expression of the Bcl 2 , Mcl 1 , Bcl 10 , Bax , and Bak proteins was analyzed to determine whether the differences in MCF 7 cell sensitivity to apoptosis could be correlated to the differential expression of these proteins . ^^^ Whereas Bak , Bcl 10 , and Mcl 1 levels were identical between variants , the levels of Bcl 2 were 3 . 5 3 . 8 fold higher and the levels of Bax were 1 . 5 1 . 7 fold lower in the resistant variants ( M and L ) as compared with those of the sensitive variant ( N ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We have previously examined the involvement of the B cell leukemia 2 gene product ( Bcl 2 ) family proteins ( Bcl 2 , Bcl 10 , Bax , Bak , and Bad ) in Alzheimer ' s disease ( AD ) and found that Bcl 2 , Bcl 10 , Bak , and Bad were upregulated . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The expression of Bax was clearly induced only on IL 2 stimulated or PMA plus ionomycin stimulated PBLs and that of other Bcl 2 family proteins such as Bcl 10 and Bad could not be detected on human PBLs , including IL 2 stimulated or PMA plus ionomycin stimulated PBLs . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Members of the Bcl 2 family of proteins , Bcl 2 , Bcl 10 ( L ) , Bcl Xs and Bax , are considered to play important roles in the regulation of apoptosis and drug resistance . ^^^ Bcl 2 and Bcl 10 ( L ) were found in 12 and nine samples , respectively . ^^^ All PCL cases showed co expression of Bcl 2 and Bcl 10 ( L ) . ^^^ Analysis of MM cases showed that Bcl 2 was preferentially expressed in samples from cases with early clinical stage while Bcl 10 ( L ) tended to be expressed in samples from cases at advanced clinical stage . ^^^ There was no correlation between the expression levels of Bcl 2 or Bcl 10 ( L ) and preceding chemotherapy . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Under respiratory growth conditions , Bcl 10 ( L ) and Bcl 2 are unable to overcome yeast cell death triggered by a mutant Bax protein lacking the membrane anchor . ^^^ However , the death inhibitory proteins Bcl 10 ( L ) and Bcl 2 fail to rescue Bax delta mediated growth inhibition under conditions promoting respiration , although they bind Bax delta in the cell . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
METHODS : Liver biopsies from 15 early ( stages 1 and 2 ) and 14 late ( stages 3 and 4 ) cases of PBC and 15 normal cases were examined immunohistochemically for expression of p 53 , CD95 / Fas , bax , bcl 10 , bcl 2 and the proliferation marker Ki 67 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Pretreatment tumor biopsies were immunohistochemically investigated for expression of p 53 , Bcl 2 , Bax ( bcl 2 associated 10 protein ) , and Bcl 10 ( L ) ( bcl 2 related 10 protein ) . ^^^ The overall expression of p 53 , Bcl 2 , Bax , and Bcl 10 ( L ) was 52 . 6 , 57 . 9 , 100 , and 97 . 4 % respectively . ^^^ Additionally , a more favorable outcome was observed in tumors positive for Bcl 2 ( not significant ) , whereas no differences in survival were observed in relation to the expression of Bax or Bcl 10 ( L ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Immunohistochemical analysis of Bcl 2 , Bax , Bcl 10 , and Mcl 1 expression in pancreatic cancers . ^^^ We found that Bcl 2 was expressed in 23 % , Bax in 53 % , Bcl 10 in 90 % , and Mcl 1 in 90 % of the invasive ductal adenocarcinomas . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Two colour cytometric analysis of permeabilized CD34+ cells stained with antibodies to Bcl 2 , Bcl 10 ( anti apoptotic ) , Bax and Bad ( pro apoptotic ) , demonstrated significantly higher ratios of pro 5 anti apoptotic proteins in early MDS ( 2 . 47 ( 1 . 19 9 . 42 ) compared to advanced disease ( 1 . 14 ( 0 . 06 3 . 32 ) , P=0 . 0001 ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Although BAX and BCL 2 expression was similar among the three cell lines , the expression of the anti apoptotic protein , BCL 10 ( L ) , was significantly lower in S 1 cells than in S 3 and DCT cells , and this may have contributed to the heightened sensitivity of S 1 cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Apoptosis regulatory proteins include those that block apoptosis such as Bcl 2 and Bcl 10 , whilst a related protein Bax promotes apoptosis . ^^^ Paraffin embedded samples from ten different lesions of squamous cell carcinoma ( SCC ) , Bowen ' s disease ( BD ) , keratoacanthomas ( KA ) , and nine normal adult skin samples were stained by immunohistochemistry to detect expression of Bcl 2 , Bcl 10 , Bax , Ki 67 , p21wafl , p 53 and apoptosis ( TUNEL assay ) . ^^^ Compared to low levels of Bcl 10 and Bcl 2 immunostaining in normal skin , all the squamoproliferative lesions had strong and diffuse KC expression of Bcl 10 ( > 80 % ) but minimal to absent KC Bcl 2 expression ( < 15 % ) . ^^^ These immunostaining profiles reveal that squamoproliferative lesions , including invasive transformed KCs , preferentially express Bcl 10 over Bcl 2 , in addition to upregulating their Bax levels . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Expression of bcl 2 , bcl 10 , bax and bak in renal parenchyma , oncocytomas and renal cell carcinomas . ^^^ Expression of bcl 2 , bcl 10 , bax and bak was investigated by immunohistochemistry and Western blotting of regular and alterated renal parenchyma as well as in 57 renal cell carcinomas . ^^^ Bcl 2 , bcl 10 and in part bax were found to be overexpressed in inflammed renal parenchyma , whereas atrophic tubuli predominantly stained for bcl 2 and to a lesser degree for bcl 10 and bax . ^^^ Moderate to strong expression for bcl 2 , bcl 10 , bax and bak was found in 24 , 38 , 2 and 13 of 57 carcinomas , respectively . ^^^ Bcl 2 , bcl 10 , bax and bak expression were correlated to tumor type . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In addition , apoptosis in these cells is accompanied by an induction of the expression of the apoptotic form of the Bcl 10 gene , the isoform Bcl xS , and by a decrease of Bcl 2 expression , Bcl xL remaining almost undetectable . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Adenovirus mediated high expression of BCL 6 in CV 1 cells induces apoptotic cell death accompanied by down regulation of BCL 2 and BCL 10 ( L ) . ^^^ Induction of apoptosis by BCL 6 was preceded by down regulation of apoptosis repressors BCL 2 and BCL 10 ( L ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
OBJECTIVE : The purpose of this study was to determine whether there is an increase in expression of bcl 2 and related bcl 2 gene family members bcl 10 and bax in liver biopsy samples obtained from patients with either hepatitis C infection or cirrhosis . ^^^ Bcl 2 , bcl 10 , and bax , as well as other bcl 2 related proteins , function coordinately through homo and heterodimerization to regulate apoptosis . ^^^ METHODS : Sections cut from archived liver biopsy samples embedded in paraffin were probed with antibody specific for bcl 2 , bcl 10 , or bax . ^^^ A similar pattern of expression was evident for bcl 10 , but in general the level of expression was limited relative to that of bcl 2 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Nonetheless , there were no significant alterations in levels of immunoreactive Bcl 2 , Bcl 10 ( L ) , Bax , Bad , and Bak , nor any evidence of cytochrome c release into cytosol and dissipation of delta ( psi ) m . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
This effect relates to a direct anti apoptotic effect of IL 10 , which is likely independent of the expression of bcl 2 , bcl 10 and fas . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Immunohistochemical staining for BCL 2 , BCLX , BAX , and p 53 was performed in 7 pediatric low grade gliomas ( LGGs ) and 7 pediatric HGGs . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
All these events are prevented by p27Kip1 overexpression . p27Kip1 does not modulate Bcl 2 , Bcl 10 ( L ) , Mcl 1 and Bax protein level in leukemic cells but suppresses Mcl 1 expression decrease observed in mock transfected U 937 cells undergoing etoposide induced cell death . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 overexpression results in reciprocal downregulation of Bcl 10 ( L ) and sensitizes human testicular germ cell tumours to chemotherapy induced apoptosis . ^^^ Analysis of potential mechanisms of sensitization revealed there was a reciprocal downregulation of the endogenously expressed Bcl 10 ( L ) in the Bcl 2 overexpressing clones . ^^^ Our results indicate that Bcl 2 and Bcl 10 ( L ) have different abilities to protect against chemotherapy induced apoptosis in testicular germ cell tumours . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
MycN overexpression and cytotoxic drugs also synergized to induce p 53 and Bax protein expression , while Bcl 2 and Bcl 10 ( L ) protein levels remained unchanged . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Analyses of apoptosis and of the apoptosis regulatory proteins Bcl 2 , Bax , Bcl 10 , and Bad were done in 95 nontumorous and neoplastic pituitary tissues by terminal deoxynucleotide transferase mediated dUTP nick end labeling ( TUNEL ) , immunohistochemistry , and Western blotting . ^^^ The lowest levels of Bcl 2 , Bax , and Bcl 10 expression were in pituitary carcinomas as detected by immunostaining . ^^^ Analysis of the Bcl 2 family of proteins after treatment with TGF beta 1 and PKC inhibitors showed a 20 % to 30 % decrease in Bcl 10 in the treated groups compared with controls . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The nuclei of neurons and glia cells were stained by in situ nick end labeling , which was more pronounced in the younger case , although the expression of both bcl 2 and bcl 10 was not significantly altered in these cases . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Tumor necrosis factor induces Bcl 2 and Bcl 10 expression through NFkappaB activation in primary hippocampal neurons . ^^^ TNF protected neurons against hypoxia or nitric oxide induced injury , with an increase in the anti apoptotic proteins Bcl 2 and Bcl 10 as determined by Western blot and reverse transcriptase polymerase chain reaction analysis . ^^^ Treatment of neurons with an antisense oligonucleotide to bcl 2 mRNA or that to bcl 10 mRNA blocked the up regulation of Bcl 2 or Bcl 10 expression , respectively , and partially inhibited the neuroprotective effect induced by TNF . ^^^ To examine the possible involvement of a transcription factor , NFkappaB , in the regulation of Bcl 2 and Bcl 10 expression in TNF treated neurons , an adenoviral vector capable of expressing a mutated form of IkappaB was used to infect neurons prior to TNF treatment . ^^^ Expression of the mutant NFkappaB completely inhibited NFkappaB DNA binding activity and inhibited both TNF induced up regulation of Bcl 2 and Bcl 10 expression and neuroprotective effect . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Immunohistochemistry was performed to examine the expression of CD 3 , CD 20 , PCA 1 , CD 40 , CD40L , Bcl 2 , Bax , and Bcl 10 on T and B lymphocytes infiltrating labial salivary glands of SS patients . ^^^ Surprisingly , the expression of Bcl 2 and Bcl 10 was colocalized with that of CD 40 determined by mirror section technique . ^^^ Bcl 10 was also abundantly expressed on infiltrating mononuclear cells , but , Bax expression was relatively less than that of Bcl 2 or Bcl 10 . ^^^ Immunohistochemical analysis also suggests that signaling through CD 40 by means of CD40L increases the expression of Bcl 2 as well as Bcl 10 in infiltrating lymphocytes , providing the resistance against apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Prognostic significance of Bcl 2 in Wilms ' tumor and oncogenic potential of Bcl 10 ( L ) in rare tumor cases . ^^^ Therefore , we examined the expression of the Bcl 10 and Bax genes , which are known to synergize and antagonize Bcl 2 , respectively . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Peripheral blood eosinophils were found to express constitutively Bax and Bcl 10 , but Bcl 2 was absent . ^^^ Culturing eosinophils in the presence of 100 pg / ml IL 5 for 24 h significantly reduced apoptosis ( P < 0 . 01 ) to 10 . 7 + / 2 . 6 % compared with 46 . 8 + / 7 . 4 % in the absence of IL 5 , and induced Bcl 2 mRNA and protein expression , with no detectable change in Bax , Bcl 10 , or beta actin as a control . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In the present study using RT PCR and in situ hybridization techniques we demonstrated that levels of mRNA for Bcl 2 and Bcl 10 decreased after axotomy . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Derangements in cell cycle control and apoptosis regulation might be responsible for the progression from metaplasia to dysplasia and adenocarcinoma We tested this hypothesis by performing cell cycle analysis , in situ detection of apoptosis , and evaluation for the immunohistochemical expression of proteins involved in proliferation ( Ki 67 ) , the control of apoptosis ( bcl 2 , bcl 10 and bax ) , and cell cycle regulation ( retinoblastoma and cyclin D 1 ) . ^^^ A statistically significant linear association was found between bcl 10 expression , bax expression , and the bcl 2 to bax expression ratio versus increasing histologic severity ( P = . 0004 , P = . 007 , and P = . 03 , respectively ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We investigated the expression of apoptosis in these diseases , using TdT mediated dUTP nick end labeling ( TUNEL ) method and immunohistochemistry with Bcl 2 , Bcl 10 , Bak and caspase 3 ( CPP 32 ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Apoptosis and expression of Bax , Bcl 10 , and Bcl 2 apoptotic regulatory proteins in colorectal carcinomas , and association with p 53 genotype / phenotype . ^^^ AIMS : Spontaneous apoptosis and expression of the apoptotic regulatory proteins Bax , Bcl 10 , and Bcl 2 were investigated in 50 colorectal carcinomas . ^^^ Staining intensities for Bax , Bcl 10 , and Bcl 2 were strong ; that is , equivalent to or greater than positive normal mucosal cells , in 11 of 50 , 20 of 49 , and 20 of 48 carcinomas . ^^^ Bax , Bcl 10 , and Bcl 2 protein expression were not correlated with tumour apoptosis or tumour DNA ploidy status . p 53 was expressed in 34 of 50 tumours and p 53 gene mutations were detected in 22 of 29 p 53 positive tumours analysed . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
METHODS : Immunohistochemistry was performed on tissue sections using antibodies against bcl 2 , bcl 10 , bax , and bak . ^^^ Both bcl 2 and bax were diffusely cytosolic whereas bcl 10 and bak exhibited a distinct perinuclear distribution . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Using quantitative Western blotting we have determined the level of expression of BCL 2 , BAX , MCL 1 , and BCL 10 in lymphoblasts from 47 children with ALL ( 33 at presentation only , 4 at relapse only , and 10 at both presentation and on relapse ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Sensitivity of S49 . 1 cells to anti CD 95 ( Fas / Apo 1 ) induced apoptosis : effects of CD 95 , Bcl 2 or Bcl 10 transduction . ^^^ Our data suggest that the resistance protein ( s ) are not Bcl 2 , Bcl 10 , Fap 1 or Bag 1 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Developmental expression patterns of Bcl 2 , Bcl 10 , Bax , and Bak in teeth . ^^^ The ontogenic profile of expression of four members of the Bcl 2 family ( Bcl 2 , Bcl 10 , Bax and Bak ) was examined in the mouse by immunohistochemistry using paraffin sections . ^^^ In general , contemporaneous co expression of the Bcl 2 and Bax proteins , and of the Bcl 10 and Bak proteins was noted in various types of cells during the developmental process , with the intensity of Bcl 2 > Bax and of Bak > Bcl 10 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In this paper , we have further characterized the sensitive and resistant phenotypes and investigated whether a different expression of the apoptotic genes Fas , FasL , Bcl 2 , Bcl 10 and Bax is involved in the regulation of Dex mediated apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In cultured keratinocytes activation of the epidermal growth factor receptor upregulates expression of Bcl 10 ( L ) , an anti apoptotic Bcl 2 homolog . ^^^ Here we demonstrate that inhibition of the epidermal growth factor receptor tyrosine kinase activity with either an epidermal growth factor receptor antagonistic monoclonal antibody ( MoAb 425 ) or an epidermal growth factor receptor selective tyrosine kinase inhibitor ( AG 1478 ) downregulated Bcl 10 ( L ) expression in normal human keratinocytes but had no effect on expression of the pro apoptotic Bcl 2 homologs Bad , Bak , and Bax . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
This bystander effect of viral infection on activated T cells was independent of effects on the magnitude of the initial T cell response , on induction of Bcl 2 and Bcl 10 , on T cell proliferation , and on Fas killing . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
RESULTS : The infection and apoptosis of CEM cells were associated with enhanced expression of Bax , Bcl 2 , Bcl 10 ( L ) and caspase 1 ( ICE ) . ^^^ The CD 8 cells of HIV infected individuals exhibited increased expression of Bcl 2 , Bcl 10 ( L ) , Bax and caspase 1 but , in contrast to the CD 4 subset , they showed elevated expression of p21CIP1 and p16INK4a compared with controls . ^^^ Increases in Bcl 2 , Bcl 10 ( L ) and caspase 1 in HIV infected CEM cells may be caused by both direct and indirect mechanisms , because they also occurred in CD 4 and CD 8 cells of HIV infected individuals . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The survival promoting effects of ITS were reduced in cells lacking both bcl 10 and bcl 2 , indicating Bcl 2 plays a supportive role to Bcl xL in maintaining telencephalic cell survival . ^^^ Furthermore , the ratio of expression of the pro apoptotic bax gene to the anti apoptotic bcl 2 gene was reduced in bcl 10 deficient cultures grown in ITS , suggesting that the interaction between these bcl 2 family members may , in part , regulate a Bcl xL independent survival pathway . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We studied the substantia nigra of three Parkinson ' s disease ( PD ) patients and three age matched individuals by in situ DNA end labeling ( ISEL ) and immunohistochemistry for the apoptosis regulating proteins Bcl 2 , Bax and Bcl 10 on 50 consecutive sections per patient . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Ninety archived paraffin embedded specimens from 25 patients ( two or more sequential biopsies each ) and eight control specimens were evaluated in immunohistochemically stained sections for tumor suppressor protein p 53 , p 53 binding protein mdm 2 , and apoptosis regulatory proteins Bcl 2 , Bcl 10 , Bax , and Bak . ^^^ These data show that apoptosis associated proteins are altered in variable patterns in both premalignant and malignant oral epithelial lesions . p 53 and especially Bak and Bcl 10 are expressed early ; Bax is largely absent ; and Bcl 2 and mdm 2 show sporadic expression in the development of oral premalignant and malignant disease . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
PURPOSE : The prognostic significance of spontaneous levels of apoptosis and Bcl 2 , Bax , and Bcl 10 protein expression in follicular center lymphoma ( FCL ) is unknown . ^^^ The objectives of this retrospective study were ( 1 ) to investigate the relationship between pretreatment apoptosis levels and long term treatment outcome in patients with Stage 1 and 2 FCL ; ( 2 ) to define the incidence and patterns of Bax and Bcl 10 protein expression in human FC ; and ( 3 ) to determine the relationship of Bcl 2 , Bax , and Bcl 10 expression with spontaneous apoptosis levels and clinical outcome in localized FCL . ^^^ Expression of Bcl 2 , Bax , and Bcl 10 proteins was assessed using immunohistochemistry . ^^^ Expression of Bcl 2 , Bax , or Bcl 10 did not correlate with AI or clinical outcome . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Thus , the pro apoptotic proteins Bax , Bak and Bad , as well as the death suppressors Bcl 10 , Bcl 2 and Bcl w , are synthesised in mouse mammary gland , and dynamic changes in the expression profiles of these proteins occurs during development . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In this lesion we identified apoptosis of vascular smooth muscle cells ( VSMCs ) by in situ DNA labelling and electron microscopy in the neointima on the 14th day after injury . mRNA expression levels of bcl 2 , bax , bcl 10 , p 53 and caspase 1 were determined by the reverse transcriptase polymerase chain reaction method both in injured and uninjured carotid arteries . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The expression of Bcl 2 family proteins ( Bcl 2 , Bcl 10 , Bcl XL , Bcl Xs , BAX , BAD , MCL 1 ) and of Interleukin 1 converting enzyme ( ICE ) related proteins ( ICE , CPP 32 , ICH 1 ) was analyzed in acute leukemia cells by flow cytometry . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The levels of other BCL 2 family members including BAX , BCL 2 , BCL 10 or MCL 1 were not consistently modulated by mutant or wild type p53val135 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
As shown earlier for bcl 2 , the expression of bcl w and bcl 10 messenger RNA in cultured cerebellar granule cells was not altered by the deprivation of neurotrophic factors . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 and Bcl 10 expression in gangliogliomas . ^^^ This study retrospectively evaluates bcl 2 and bcl 10 immunostaining in paraffin embedded materials in gangliogliomas . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Downregulation of Bcl 2 , but not of Bax or Bcl 10 , is associated with T lymphocyte apoptosis in HIV infection and restored by antiretroviral therapy or by interleukin 2 . ^^^ The role of Bcl 2 , Bax , and Bcl 10 in the apoptosis of T lymphocytes in HIV infected individuals was investigated . ^^^ In contrast to Bcl 2 , no correlation is detectable between Bax or Bcl 10 expression and apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Apoptotic cell death , MIB 1 , p 53 , bcl 2 and bcl 10 were examined by the terminal deoxynucleotidyl mediated dUTP nick end labelling method and immunohistochemistry . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 , Bax and Bcl 10 expression following kainic acid administration at convulsant doses in the rat . ^^^ To assess the involvement of members of the Bcl 2 family in cell death or survival , immunohistochemistry , western and northern blotting to Bcl 2 , Bcl 10 and Bax , and in situ hybridization to Bax were examined at different time points after kainic acid treatment . ^^^ Dying neurons in the pyramidal cell layer of CA 1 and CA 3 areas , entorhinal and piriform cortices , and amygdala also expressed Bcl 2 , Bax and Bcl 10 following excitotoxicity , although many dying cells did not . ^^^ Western blots disclosed no modifications in the intensity of the bands corresponding to Bcl 2 , Bcl 10 and Bax , between control and kainic acid treated rats . ^^^ The present results suggest that cell death or survival does not correlate with modifications of Bcl 2 , Bax and Bcl 10 protein , and messenger RNA expression , but rather that kainic acid excitotoxicity is associated with Bax translocation to the nucleus in a subset of dying cells . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The expression of the mitochondrial factors Bcl 2 , Bcl 10 , and Bax was determined because each has been implicated in the regulation or release of cytochrome c at the level of the mitochondria . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The expression of the pro apoptotic proteins ( Bax , Bak ) and anti apoptotic proteins ( Bcl 2 , Bcl 10 , Mcl 1 ) was studied by immunohistochemistry in 110 invasive ductal breast carcinomas . ^^^ Overall , Bcl 2 , Bcl 10 , Mcl 1 , Bax , Bak , ER , and p 53 were detected in 62 , 75 , 68 , 75 , 60 , 68 and 26 per cent of the cases respectively , but at different levels in each case . ^^^ The expression of Bcl 2 and Bcl 10 was correlated to that of ER . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 and Bcl 10 ( L ) block thapsigargin induced nitric oxide generation , c Jun NH ( 2 ) terminal kinase activity , and apoptosis . ^^^ The proteins Bcl 2 and Bcl 10 ( L ) prevent apoptosis , but their mechanism of action is unclear . ^^^ We examined the role of Bcl 2 and Bcl 10 ( L ) in the regulation of cytosolic Ca ( 2+ ) , nitric oxide production ( NO ) , c Jun NH ( 2 ) terminal kinase ( JNK ) activation , and apoptosis in Jurkat T cells . ^^^ By contrast , while TG produced comparable early changes in the Ca ( 2+ ) level ( i . e . , within 3 h ) in Jurkat cells overexpressing Bcl 2 and Bcl 10 ( L ) ( JT / Bcl 2 or JT / Bcl 10 ( L ) ) , NO production , late ( 36 h ) Ca ( 2+ ) accumulation , and apoptosis were dramatically reduced compared to those in JT / Neo cells . ^^^ Exposure of JT / Bcl 2 and JT / Bcl 10 ( L ) cells to the NO donor , S nitroso N acetylpenacillamine ( SNAP ) resulted in apoptosis comparable to that seen in JT / Neo cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We have previously shown that Akt inhibits the activity of DEVD targeted caspases without changing the steady state levels of Bcl 2 and Bcl 10 ( L ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The incidence of apoptotic nuclei ( < 1 % ) as evidenced by the terminal deoxynucleotidyl transferase mediated dUTP nick end labeling ( TUNEL ) method , and the histological distribution of immunoreactive Bcl 2 , Bax , and Bcl 10 proteins , were similar in placentae collected after delivery and before the onset of labor and in placental explants maintained overnight at 4 degrees C in a minimal salt Hepes medium . ^^^ This marked increase was associated with a decrease in the intensity of the Bcl 2 immunostaining and an increase in the intensity of Bax and Bcl 10 immunostaining . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
No significant changes in Bcl 2 , BclX , and Bax protein expression level were observed in the transfected clones as compared with the control H 460 cells whereas a 2 fold increase in Bak protein levels was noticed . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
This effect was specific to bcl 2 , as expression of other members of the bcl 2 family ( bax , bcl 10 ( L ) , bcl 10 ( S ) , and bad ) was unaffected by estradiol treatment . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The elevated apoptosis was not due to alterations in expression or to mutations in Bcl 2 , Bcl 10 ( L ) , or Flip , nor could the spontaneous apoptosis be prevented by blocking Fas , suggesting that it was independent of Fas signaling . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Heterogenous susceptibility to CD 95 induced apoptosis in melanoma cells correlates with bcl 2 and bcl 10 expression and is sensitive to modulation by interferon gamma . ^^^ We tested an unselected panel of 11 melanoma cell lines for sensitivity to CD 95 and the corresponding expression of CD 95 , CD95L , bcl 2 , bcl 10 , bcl xS , bax and FLIP proteins . ^^^ Apoptosis related proteins CD95L , bcl 2 , bcl 10 , bcl xS and bax were found to be heterogenously expressed in different melanoma cell lines tested . ^^^ The susceptibility of melanoma cells to anti CD 95 MAb mediated apoptosis was associated with low protein expression of both bcl 2 and bcl 10 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Mammary gland tissue , similar to many other tissues , expresses a number of different Bcl 2 relatives including bcl 10 , bax , bak , bad , bcl w , bfl 1 , bcl 2 as well as the bcl 2 binding protein Bag 1 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Members of the Bcl 2 family of apoptosis regulatory molecules ; Bcl 2 and Bcl 10 , appear to have some role in regulating apoptosis in the terminal endbud . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Of the small cell heterogeneous basophilic lesions , 86 % of foci ( 31 / 36 ) and 85 % of adenomas ( 35 / 41 ) exhibited increased bcl 2 protein levels compared with surrounding normal hepatocytes , whereas only 12 . 5 % of foci ( 4 / 36 ) and 12 % of adenomas ( 5 / 41 ) exhibited increased bcl 10 ( L ) levels . ^^^ Of the large cell , homogenous , basophilic lesions , 100 % of foci ( 3 / 3 ) and 90 % of adenomas ( 9 / 10 ) expressed bcl 2 protein , whereas 100 % of foci ( 3 / 3 ) and 80 % of adenomas ( 8 / 10 ) exhibited increased bcl 10 ( L ) protein levels compared with surrounding normal hepatocytes . ^^^ Of the acidophilic lesions , the majority of foci ( 28 / 32 , 88 % ) and adenomas ( 47 / 50 , 94 % ) expressed increased bcl 10 ( L ) , whereas increased bcl 2 was observed in only 12 . 5 % of acidophilic preneoplastic foci ( 4 / 32 ) and 14 % of acidophilic adenomas ( 7 / 50 ) . ^^^ Of the carcinomas analyzed , 81 % expressed increased bcl 2 ( 54 / 67 ) , 78 % expressed increased bcl 10 ( L ) ( 52 / 67 ) and 69 % expressed increased levels of both bcl 2 and bcl 10 ( L ) ( 46 / 67 ) . ^^^ Collectively , only 8 % of preneoplastic foci , 3 % of adenomas and 1 . 5 % of carcinomas did not express either bcl 2 or bcl 10 ( L ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Cell culture studies of erythroid progenitors have suggested that Epo functions as a survival factor by repressing apoptosis at least in part through Bcl 10 ( L ) , an anti apoptotic protein of the Bcl 2 family . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The expression of Bcl 2 and Bcl 10 ( L ) correlated with that of BAG 1 in breast normal and carcinoma cell lines but not tissues . ^^^ Our study suggests that BAG 1 isoforms may serve as a molecular marker , independent of Bcl 2 and Bcl 10 ( L ) , for human breast cancer . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Analysis of the expression of the cell death regulators , Bcl 2 and Bcl 10 , revealed that the level of Bcl 10 was lower in Ba / F3 cells expressing STAT5A delta 749 than in control cells . ^^^ IL 3 regulation of Bcl 10 expression at protein and mRNA levels was impaired in these cells while that of Bcl 2 expression was unaffected . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Examination of expression levels of Bcl 2 protoncogene family members ( Bcl 2 , Bcl 10 ( L ) , Mcl 1 , and Bax ) showed a downregulation of Bcl 10 ( L ) and Mcl 1 after CD 22 ligation . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In this study , the expression of four apoptosis related proteins ( bcl 2 , bcl 10 , bax and p 53 ) in 53 cases of HD was examined and the data were correlated with the genotype , the EBV status and the phenotype ( B , T or null ) of the neoplastic cells . ^^^ The H RS cells were bcl 2 positive in 19 / 53 ( 36 % ) , bcl 10 positive in 17 / 53 ( 32 % ) , bax positive in 1 / 53 , and p 53 positive in 41 / 53 ( 77 % ) cases . ^^^ No relationship was found between bcl 2 expression and EBV status , or between bcl 2 and bcl 10 expression . ^^^ They also suggest a role for bcl 2 , bcl 10 and p 53 in tumorigenesis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 10 ( L ) , an anti apoptotic member of the Bcl 2 family was shown to interact with the carboxyl terminal fragments of PS 1 and PS 2 by the yeast two hybrid system . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Apaf 1 did not bind , however , to any of the six known mammalian prosurvival family members ( Bcl 2 , Bcl 10 ( L ) , Bcl w , A 1 , Mcl 1 , or Boo ) , or their viral homologs adenovirus E1B 19K and Epstein Barr virus BHRF 1 . ^^^ Endogenous Apaf 1 also failed to coimmunoprecipitate with endogenous Bcl 2 or Bcl 10 ( L ) , or with two proapoptotic relatives ( Bax and Bim ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Here , the expression of bcl 2 family members ( bcl 2 , bax , bad , and bcl 10 ( s / l ) ) and caspases 1 , 2 , 3 , 4 , and 6 was investigated through a range of stages of chick lens development using immunocytochemistry , Western blotting , and affinity labelling for caspases using biotinylated caspase inhibitors . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In glioblastoma cells , induction of Bcl 2 alone at a high level induced apoptosis , whereas induction of Bcl 10 ( L ) alone did not . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
To study the possible roles of bcl 2 family proteins in oncogenesis and cytodifferentiation of odontogenic epithelium , the expression of bcl 2 , bcl 10 and bax proteins was examined immunohistochemically in tooth germs and various types of ameloblastoma . ^^^ In ameloblastomas , bcl 2 and bcl 10 proteins were expressed intensely in peripheral columnar cells and weakly in central polyhedral cells , while bax protein reactivity was low . ^^^ Basal cell ameloblastomas showed intense reactivity for bcl 2 and bcl 10 proteins , but slight or no reactivity for bax protein . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The BH 3 domain of Bcl 10 ( S ) is required for inhibition of the antiapoptotic function of Bcl 10 ( L ) . bcl 10 is a member of the bcl 2 family of genes . ^^^ Unlike other proapoptotic Bcl 2 family members , such as Bax and Bak , Bcl 10 ( S ) does not seem to induce cell death in the absence of an additional death signal . ^^^ Deletion mutants of Bax and Bcl 2 , which lacked BH 1 and BH 2 domains but contained a BH 3 domain , were able to antagonize the survival effect conferred by Bcl 10 ( L ) . ^^^ The results suggest that BH 3 domains from both pro and antiapoptotic Bcl 2 family members , while lacking an intrinsic ability to promote programmed cell death , can be potent inhibitors of Bcl 10 ( L ) survival function . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
A new apoptosis inhibitor of the bcl 2 gene family , bcl 10 ( L ) , was recently found in some types human neoplasia but not in normal tissue . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
It has been demonstrated that Bcl 10 ( L ) ( Bcl 10 ( L ) = protein , bcl 10 ( L ) = gene ) , a Bcl 2 related protein , prevents apoptosis in mammalian cells . ^^^ Additionally , TGF beta 1 is able to protect cultured neuronal cells from Abeta induced apoptosis via upregulation of bcl 10 ( L ) and bcl 2 gene expression . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In this study , hippocampal slices of a 5 week old rat were transiently introduced with plasmid DNA carrying anti apoptotic rat bcl 2 or bcl 10 cDNA by a particle bombardment transfection procedure . ^^^ Intact plasmid DNAs were recovered by PCR amplification from the slices with bcl 2 or bcl 10 cDNAs but not from slices with empty vector or bax cDNA that promotes cell death . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Unexpectedly , we found a paradoxical effects of 17beta oestradiol on two anti apoptotic proteins Bcl 2 and Bcl 10 . ^^^ Treatment with 17beta oestradiol resulted in up regulation of Bcl 2 mRNA and protein , but down regulated Bcl 10 ( L ) mRNA and protein . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Detachment induced caspase 8 activation did not require the function of downstream caspases but was blocked by overexpression of the anti apoptotic proteins Bcl 2 or Bcl 10 ( L ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The GnRH Ag induced decrease in the 18 kDa PBR protein also correlated with the reduction in the Bcl 10 ( L ) , but not Bcl 2 ( cell survival ) , gene product levels and the increase in the Bax ( cell death ) gene product expression in the luteal mitochondrial preparations . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
As Bcl 2 related proteins are involved in apoptotic process , we also evaluated their role by examining the expression of Bcl 2 , Bcl 10 ( L ) , and Bax on SEB FK 506 treated murine splenic T cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 , Bcl 10 , Bax , and Bak expression in short and long lived patients with diffuse large B cell lymphomas . ^^^ The expression of the apoptosis regulating proteins , Bcl 2 , Bcl 10 , Bax , and Bak , in the initial biopsy samples was examined with immunohistochemical methods . ^^^ An inverse association was found between length of patient survival and expression of Bcl 2 , Bcl 10 , and Bax . ^^^ Several combinations of protein expression , i . e . , Bcl 2 with Bax , Bcl 2 with Bcl 10 , and Bcl 10 with Bax , were different between the groups : a positive expression of these proteins was found in the short lived patients . ^^^ Furthermore , a strong association was found between the expression of Bcl 2 and Bcl 10 , suggesting that Bcl 10 potentiates rather than replaces the effect of Bcl 2 in NHL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Tamoxifen induced apoptosis in breast cancer cells relates to down regulation of bcl 2 , but not bax and bcl 10 ( L ) , without alteration of p 53 protein levels . ^^^ In this study , we investigated the effects of TAM on bcl 2 family gene products bcl 2 , bax , and bcl 10 ( L ) and on p 53 levels in estrogen receptor positive MCF 7 breast cancer cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Expression of p 53 also had no effect on the expression levels of proteins such as Fas , GADD 45 , Bax , Bcl 2 , Bcl 10 ( L ) or p 53 induced proteins ( PIGS ) in resting cells or after irradiation . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Using the GM CSF dependent TF 1 myeloid leukaemia cell line , the authors show that the endogenous levels of BCL 2 and MCL 1 are downregulated upon GM CSF withdrawal , whereas the levels of BCL 10 ( L ) and Bax are unchanged . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Expression of Bcl 2 , Bax , Bcl 10 , and Mcl 1 proteins and of the proliferation marker Ki 67 was evaluated by immunohistochemistry . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
CD 80 expression by leukemic cells leads to increased survival of activated T cells by inducing upregulation of the antiapoptotic protein BCL 2 , but not BCL 10 ( L ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The differences of expression of BCL 2 , BCL 10 , BAX , and MCL 1 proteins of paired first resection and recurrence glioblastoma specimens were examined . ^^^ RESULTS : In the whole group , we found a significant up regulation of antiapoptotic BCL 2 ( median cumulative score of 15 in the primary , 19 at recurrence ; p < 0 . 0001 in the Wilcoxon test ) , BCLX ( median scores 20 and 25 , respectively , p < 0 . 0001 ) , and MCL 1 ( median scores 11 and 14 , p=0 . 0395 ) , and a significant down regulation of proapoptotic BAX ( median scores 14 and 11 , p < 0 . 0001 ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The expression of Bcl 2 , Bax , and Bcl 10 was not changed among Jurkat , Tax ( ) JPX 9 , and Tax ( + ) JPX 9 cells in the presence or absence of NF kappaB inhibitors . 10 chromosome linked inhibitor of apoptosis ( XIAP ) protein expression in Tax ( ) JPX 9 cells was significantly suppressed by NF kappaB inhibitors , however , its expression in Tax ( + ) JPX 9 cells was maintained even by the addition of NF kappaB inhibitors . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The expression of Bcl 2 and Bcl 10 ( L ) as quantitated by Western blotting was 1 . 2 to 1 . 9 fold higher in the treated groups . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Apoptosis and expression of apoptosis regulating proteins bcl 2 , mcl 1 , bcl 10 , and bax in malignant mesothelioma . ^^^ We investigated apoptosis and the expression of bcl 2 , mcl 1 , bcl 10 , and bax in histological sections from 35 malignant mesotheliomas and 21 metastatic adenocarcinomas . ^^^ Moreover , the expression of bcl 2 , mcl 1 , bcl 10 , and bax were assessed by Western blotting in nonmalignant human mesothelial cells ( Met5A ) and seven malignant cell lines . ^^^ Patients with mesotheliomas showing a high apoptotic index ( > or =0 . 75 % ) had a worse prognosis ( P = 0 . 008 ) . bcl 2 positivity was observed in only seven cases , but bcl 10 , mcl 1 , and bax positivity was seen in all of them . ^^^ In immunoblotting experiments , all mesothelioma cell lines were negative for bcl 2 but positive for bcl 10 , mcl 1 , and bax . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 10 ( L ) , a prosurvival member of the Bcl 2 family that is expressed in many tumors , represses apoptosis induced by chemotherapeutic drugs in vitro . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In addition , bcl 10 ( s ) does not possess the 5th and 6th alpha helices ( thought to be the membrane spanning domains in bcl 2 , bcl 10 ( L ) , and bax ) and , therefore , should not be able to form membrane channels , thus eliminating this possible mechanism of action . ^^^ The finding that bcl 10 ( s ) kills 3T3 cells without caspase activation , along with the absence of membrane spanning domains in bcl 10 ( s ) , may , therefore , represent a novel cell death pathway for the pro death bcl 2 family members . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Immunohistochemical analysis revealed a selective decrease in bcl 10 , but not bcl 2 , expression in the CD 15 ( + ) / CD34 ( ) / CD33 ( ) cell population compared with similar subpopulations of control bone marrow derived myeloid precursors . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bad is a critical regulatory component of the intrinsic cell death machinery that exerts its death promoting effect upon heterodimerization with the antiapoptotic proteins Bcl 2 and Bcl 10 ( L ) . ^^^ Growth factors promote cell survival through phosphorylation of Bad , resulting in its dissociation from Bcl 2 and Bcl 10 ( L ) and its association with 14 3 3tau . ^^^ PAK phosphorylates Bad in vitro and in vivo on Ser 112 and Ser 136 , resulting in a markedly reduced interaction between Bad and Bcl 2 or Bcl 10 ( L ) and the increased association of Bad with 14 3 3tau . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Activation of Fas by FasL induces apoptosis by a mechanism that can not be blocked by Bcl 2 or Bcl 10 ( L ) . ^^^ In contrast , Bcl 2 or Bcl 10 ( L ) did not block FasL induced apoptosis in lymphocytes or hepatocytes , demonstrating that signaling for cell death induced by Fas and the pathways to apoptosis regulated by the Bcl 2 family are distinct . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The aim of this study was to determine the role of Bcl 2 , Bcl 10 L , Bax , and c Fos in regulation of apoptosis , induced by ultraviolet light A ( UV A ) and daunorubicin ( DNR ) , in retinal pigment epithelium ( RPE ) cells grown on bovine extracellular matrix ( ECM ) coated or uncoated plastic dishes . ^^^ Cellular expression of Bcl 2 , Bcl 10 L , Bax , and c Fos was determined by the use of antibodies and flow cytometry , Western blot analysis , and immunocytochemical staining . ^^^ After UV A or DNR treatment , Bcl 2 , Bcl 10 L , Bax , and c Fos levels were differently regulated in cells grown on ECM coated dishes compared to cells grown on uncoated dishes . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The calcitriol induced apoptosis is accompanied by a down regulation of Bcl 2 and Bcl 10 ( L ) proteins , both of which protect cells from undergoing apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We investigated how survival signals in the cellular microenvironment affect the expression , protein conformation , and protein protein interactions of the Bcl 2 family proteins Bax and Bcl 10 ( L ) and how changes in response to microenvironmental signals alter the response of cancer cells to the drug etoposide . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Here , using yeast two hybrid and co immunoprecipitation studies , we show that RAD 9 , a human protein involved in the control of a cell cycle checkpoint , interacts with the anti apoptotic Bcl 2 family proteins BCL 2 and BCL 10 L , but not with the pro apoptotic BAX and BAD . ^^^ When overexpressed in mammalian cells , RAD 9 induces apoptosis that can be blocked by BCL 2 or BCL 10 L . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Furthermore , an additional 18 kDa Bax related protein was expressed by the stimulation of G CSF or IL 6 , while Bcl 2 and Bcl 10 proteins remained unchanged . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
BNIP 3 heterodimerizes with Bcl 2 / Bcl 10 ( L ) and induces cell death independent of a Bcl 2 homology 3 ( BH 3 ) domain at both mitochondrial and nonmitochondrial sites . ^^^ BNIP 3 expressed in yeast and mammalian cells interacts with survival promoting proteins Bcl 2 , Bcl 10 ( L ) , and CED 9 . ^^^ Typically , the BH 3 domain of pro apoptotic Bcl 2 homologues mediates Bcl 2 / Bcl 10 ( L ) heterodimerization and confers pro apoptotic activity . ^^^ Deletion mapping of BNIP 3 excluded its BH 3 like domain and identified the NH ( 2 ) terminus ( residues 1 49 ) and TM domain as critical for Bcl 2 heterodimerization , and either region was sufficient for Bcl 10 ( L ) interaction . ^^^ Substitution of the BNIP 3 TM domain with that of cytochrome b ( 5 ) directed protein expression to nonmitochondrial sites and still promoted apoptosis and heterodimerization with Bcl 2 and Bcl 10 ( L ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Two molecules belonging to the Bcl 2 family , Bcl 2 and Bcl 10 ( L ) , protect cells from Bax induced apoptosis and show distinct expression patterns in adult neurons , with downregulated Bcl 2 and highly upregulated Bcl 10 ( L ) expression . ^^^ To investigate the biological functions of these two molecules in Bax mediated apoptosis in neurons , we transduced various levels of Bcl 10 ( L ) or Bcl 2 via adenoviral vectors into nerve growth factor ( NGF ) treated PC 12 cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Arsenic induces apoptosis of multidrug resistant human myeloid leukemia cells that express Bcr Abl or overexpress MDR , MRP , Bcl 2 , or Bcl 10 ( L ) . ^^^ These included chronic myelocytic leukemia ( CML ) blast crisis K 562 and HL 60 / Bcr Abl cells , which contain p 210 and p 185 Bcr Abl , respectively , and HL 60 cell types that overexpress Bcl 2 ( HL 60 / Bcl 2 ) , Bcl 10 ( L ) ( HL 60 / Bcl 10 ( L ) ) , MDR ( HL 60 / VCR ) , or MRP ( HL 60 / AR ) protein . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 and Bcl 10 ( L ) limit apoptosis upon infection with alphavirus vectors . ^^^ Infection with the dsSV CAT vector resulted in the rapid death of BHK and CHO cells within 4 days , a phenomenon which was considerably delayed by stably overexpressing bcl 2 or bcl 10 ( L ) . ^^^ In fact , cellular lifespans were doubled in both BHK bcl 2 and CHO bclx ( L ) cells relative to the parental cell lines . ^^^ Overexpression of bcl 2 and bcl 10 ( L ) also altered the response of these cells upon infection with SFV IL 12 . ^^^ While the parental cell lines were completely nonviable within 1 week , the BHK bcl 2 , BHK bclx ( L ) , and CHO bclx ( L ) cells each recovered from the infection , resuming exponential growth and regaining viabilities of over 90 % by 9 days post infection . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The overexpression of bcl 2 and bcl 10 ( L ) , however , was able to abrogate the cell death in BHK cultures , though to varying degrees . ^^^ During these studies , Bcl 10 ( L ) was consistently able to afford cells the highest degree of protection , though Bcl 2 also enhanced culture viabilities and viable numbers . ^^^ Death suppression following exposure to 50 mM ammonium chloride was observed to a limited extent in both BHK and CHO cells overexpressing bcl 2 and bcl 10 ( L ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The apoptosis resistant phenotype of A 11 cells was associated with the expression level of caspase 3 , but not with those of Bcl 2 , Bcl 10 ( L ) Bax , p27Kip1 and DAP kinase . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
This study hypothesized that apoptosis regulatory genes other than Fas Fas ligand , such as p 53 , p 21 ( Waf1 / Cip1 ) , bcl 2 , bcl 10 , and bax , may also participate in epithelial cell apoptosis in this model . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Role of Bcl 2 family proteins ( Bax , Bcl 2 and Bcl 10 ) on cellular susceptibility to radiation in pancreatic cancer cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
A hepatotoxic dose of acetaminophen modulates expression of BCL 2 , BCL 10 ( L ) , and BCL 10 ( S ) during apoptotic and necrotic death of mouse liver cells in vivo . ^^^ The protein BCL 10 ( L ) and protein product of proto oncogene bcl 2 act as apoptosis antagonists , and BCL 10 ( S ) serve as a dominant death promoter , including apoptosis following exposure to chemotherapeutic drugs . ^^^ This investigation examined whether some aspects of the highly integrated process of acetaminophen ( AAP ) induced hepatotoxicity involve down regulation or upregulation of expression of BCL 2 , BCL 10 ( L ) and BCL 10 ( S ) in mouse liver in vivo . ^^^ Western blot analysis of the liver proteins revealed that mouse liver expresses two proteins , BCL 10 ( L ) and BCL 10 ( S ) , and does not express BCL 2 . ^^^ In the same time period , death inhibitory gene bcl 2 remained unexpressed , and the level of expression of BCL 10 ( S ) remained unaltered . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The tumors were additionally analyzed for amplification and rearrangement of the BCL 2 gene at 18q21 as well as for mutation of the recently cloned BCL 10 gene at 1p22 . ^^^ Taken together , our data do not support a role of BCL 2 rearrangement / amplification and BCL 10 mutation in PCNSL but indicate a number of novel chromosomal regions that likely carry yet unknown tumor suppressor genes or proto oncogenes involved in the pathogenesis of these tumors . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Transgenic mice overexpressing Bcl 10 ( L ) , another anti apoptotic bcl 2 family member , under the control of the K 14 promoter , reportedly also display accelerated catagen development . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The IL 2 receptor promotes lymphocyte proliferation and induction of the c myc , bcl 2 , and bcl 10 genes through the trans activation domain of Stat 5 . ^^^ Additionally , the ability of this receptor mutant to induce c myc , bcl 10 , and bcl 2 was enhanced by overexpression of wt Stat 5 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 : bax and bcl 2 : Bcl 10 ratios by image cytometric quantitation of immunohistochemical expression in ovarian carcinoma : correlation with prognosis . ^^^ Bax and bcl 10 are members of the bcl 2 family ; when overexpressed , they can counteract the ability of bcl 2 to inhibit apoptosis . ^^^ This suggests a model in which the ratios of bcl 2 to bax and bcl 10 can be used to determine response to therapy and prognosis . ^^^ The expression of bcl 2 , bax and bcl 10 was studied in 50 ovarian carcinomas . ^^^ The ratios were obtained by dividing the PPA of bcl 2 by the PPA of bax and bcl 10 . 17 of 50 ovarian carcinomas ( 34 % ) stained positively for bcl 2 , 39 for bax ( 78 % ) and 47 for bcl 10 ( 94 % ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We examined immunohistochemically 4 apoptosis regulating bcl 2 familial proteins ( bcl 2 , mcl 1 , bcl 10 , and bax ) in the biliary epithelium in 19 cases of primary biliary cirrhosis . ^^^ Bcl 2 and mcl 1 are inhibitors of apoptosis , bcl 10 , probably bcl XL in biliary epithelial cells , an inhibitor , and bax , a promoter of apoptosis . ^^^ Expression levels of mcl 1 , bcl 10 , and bax were similarly reduced to that of bcl 2 in these 2 diseases . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
GDNF pretreatment caused up regulation of Bcl 2 and Bcl 10 . ^^^ These findings indicate that GDNF has no effect on necrosis but exerts protection against apoptosis by activation of phosphatidylinositol 3 kinase and the subsequent up regulation of Bcl 2 and Bcl 10 , which suppresses accumulation of oxygen radicals followed by caspase 3 activation . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In an effort to understand this role , we have used polyomavirus transformed pyF 111 rat fibroblasts , which are hypersusceptible to apoptosis as they constitutively hyperexpress PKC delta , but can not make the antiapoptotic Bcl 2 and Bcl 10 ( L ) proteins , while making the proapoptotic Bax protein . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Expression of bcl 2 and bcl 10 genes in lymphocytes and tumor cell lines derived from MDV infected chickens . ^^^ To characterize the molecular events involved in both apoptosis and transformation process induced by Marek ' s disease virus ( MDV ) , the expressions of the bcl 2 and bcl 10 genes , ones of the dominant apoptosis regulating genes , in Marek ' s disease ( MD ) tumor cell lines and cells prepared from MDV infected chickens were analyzed . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Overexpression of BCL 2 , BCL 10 , and BAX in primary central nervous system lymphomas that occur in immunosuppressed patients . ^^^ The BCL 2 family proteins ( BCL 2 , BCL 10 , MCL 1 , and BAX ) and p 53 expression were studied by immunohistochemistry on paraffin slides . ^^^ In contrast , PCNSLs in immunosuppressed patients were shown to express high levels of BCL 2 , BCL 10 , and BAX in more than 80 % of tumor cells in 7 , 10 , and 11 cases , respectively . ^^^ In immunocompetent patients , only one case showed a high level of BCL 2 expression in more than 80 % of the cells , whereas BCL 10 and BAX were overexpressed in two cases . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
This study analyzes the temporal and spatial relationship between expression of pro and anti apoptotic members of the Bcl 2 gene family ( Bcl 2 , Bcl 10 ( L ) , Bax ) and epidermal growth factor ( EGF ) , insulin like growth factor ( IGF 1 ) , and transforming growth factor beta ( TGF beta ) , growth factors that are thought to be reparative in ARF . ^^^ In control kidneys , expression of Bcl 2 , Bcl 10 ( L ) was low in epithelium of distal tubules , Bax had low to moderate expression in the proximal tubule and had low expression in the distal tubule , EGF and IGF 1 had low to moderate expression in the distal tubule , and TGF beta had low expression in the proximal tubule . ^^^ In contrast , within 24 h of reperfusion , distal tubules showed a marked increase in expression of Bcl 2 and a moderate increase in Bcl 10 ( L ) and Bax . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 , Bax , Bcl 10 ( L ) and Bcl 10 ( S ) expression in neoplastic and normal endometrium . ^^^ The two anti apoptotic proteins Bcl 2 and Bcl 10 ( L ) , and the two pro apoptotic proteins Bax and Bcl 10 ( S ) were measured by Western blotting in 51 neoplastic and 8 normal endometrial samples . ^^^ Interestingly , Bcl 2 and Bcl 10 ( L ) protein content showed a trend towards an inverse correlation ( r = 0 . 27 , p < 0 . 052 ) . mRNA and protein levels directly correlated only with Bcl 2 ( r = 0 . 63 , p < 0 . 0032 ) . ^^^ Despite the fact that the amounts of Bcl 2 , Bax and Bcl 10 ( L ) proteins in the neoplastic population were not significantly differently distributed according to the clinicopathological features of the patients , the differences observed between normal and neoplastic samples suggest that these proteins may play a role in endometrial carcinoma : long term follow up studies will be required to confirm this hypothesis . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Analysis of the expression of the Bcl 2 members indicated that phosphorylation of Bad and Bcl 10 expression which are respectively regulated by the PI 3 kinase / Akt pathway and STAT 5 probably explain this cooperation . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 family proteins govern this mitochondria dependent apoptosis pathway , with proteins such as Bax functioning as inducers and proteins such as Bcl 2 and Bcl 10 ( L ) serving as suppressors of cell death . ^^^ The BAR protein contains a SAM domain , which is required for its interactions with Bcl 2 and Bcl 10 ( L ) and for suppression of Bax induced cell death in both mammalian cells and yeast . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
To examine this issue , we investigated cell cycle ( c myc , p 53 , p21 / WAF ) and apoptosis related ( bcl 2 , bcl 10 ( L ) , bax alpha ) gene expression in two cell lines of very different origin under proliferating and apoptosis inducing conditions . ^^^ Furthermore colcemid treated MG 63 cells exhibited elevated bcl 2 and bax alpha expression while similar treatment of 293 0 cells resulted in decreased bcl 10 ( L ) and slightly increased bax alpha expression . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
MK enhanced the expression of Bcl 2 , but not that of Bcl 10 ( L ) , in G 401 cells in a dose dependent manner , and it prevented the Bcl 2 reduction due to CDDP . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Overexpression of anti apoptotic members of the Bcl 2 family such as Bcl 2 and Bcl 10 ( L ) has been implicated in cancer chemoresistance , whereas high levels of pro apoptotic proteins such as Bax promote apoptosis and sensitize tumor cells to various anticancer therapies . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
It sharply increased in all tissues 4 hours after AMPH treatment ( 10 mg / kg ) , and declined to basal levels at 8 to 12 hours in liver and N 12 , but remained high up to 18 hours in N 30 and HCC . c myc , Tgf alpha , p 53 , and Bcl 10 ( S ) messenger RNA ( mRNA ) levels were higher , and Bcl 2 mRNA was lower in N 12 and / or N 30 and HCC than in normal liver . ^^^ Four hours after AMPH injection , increase in c myc and decreases in Bcl 2 and Bcl 10 ( L ) mRNAs occurred in all tissues , whereas p 53 , Bax , and Bcl 10 ( S ) mRNAs increased in N 30 and HCC . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Here , we demonstrate that NF kappaB differentially regulates the expression of particular Bcl 2 related death inhibitors and that it directly activates the expression of Bcl 10 ( L ) . ^^^ While Bcl 10 ( L ) was significantly upregulated by c Rel and RelA , Bcl 2 was not . ^^^ These results establish that NF kappaB directly regulates the expression of distinct prosurvival factors in the Bcl 2 family , such as Bcl 10 ( L ) and Bfl 1 / A1 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Furthermore , BH 4 oligopeptides of Bcl 2 and Bcl 10 ( L ) , but not mutant peptides , were able to inhibit both VDAC activity on liposomes even in the presence of Bax and apoptotic Deltapsi loss in isolated mitochondria . ^^^ These results indicate that the BH 4 of Bcl 2 / Bcl 10 ( L ) is essential and sufficient for inhibiting VDAC activity , which in turn prevents apoptotic mitochondrial changes , and for preventing apoptotic cell death . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In this report , we show that the opposing actions of MR and GR on neuronal survival result from their ability to differentially influence the expression of members of the bcl 2 gene family ; specifically , in the rat hippocampus , activation of GR induces cell death by increasing the ratio of the proapoptotic molecule Bax relative to the antiapoptotic molecules Bcl 2 or Bcl 10 ( L ) ; the opposite effect is observed after stimulation of MR . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 , bcl 10 , and bax expression in dysembryoplastic neuroepithelial tumors . ^^^ BACKGROUND : Bcl 2 , bcl 10 and bax are regulatory proteins which are variably expressed in brain tissue and are known to be involved in the regulation of apoptosis ; bcl 2 and bcl 10 inhibit apoptosis and bax generally promotes apoptosis . ^^^ The oligodendroglial like cells of DNT stained positively for bcl 2 in 2 / 17 tumors , bcl 10 in 10 / 17 tumors , and bax in 12 / 17 tumors . ^^^ The neuronal cell component of the DNT stained positively with bcl 2 in 15 / 17 tumors , bcl 10 in 5 / 17 tumors , and bax in 8 / 17 tumors . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The expression patterns of the calcium binding proteins calbindin and parvalbumin and of the apoptosis modulating proteins Bcl 2 , Bax , and Bcl 10 were studied in the cerebellum of patients with multiple system atrophy ( MSA ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Anti apoptotic Bcl 2 and Bcl 10 ( L ) were upregulated by FAMP when cells entered apoptosis ( AxV ( lo ) ) , as was pro apo ptotic Bcl 10 ( S ) , which was undetectable in nonapoptotic AxV ( neg ) cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The BCL 2 family includes both proapoptotic ( e . g . , BAX and BAK ) and antiapoptotic ( e . g . , BCL 2 and BCL 10 ( L ) ) molecules . ^^^ We examined the function of BAX and BCL 10 ( L ) using genetic and biochemical approaches in budding yeast because studies with yeast suggest that BCL 2 family members act upon highly conserved mitochondrial components . ^^^ We also assessed the function of BCL 10 ( L ) and BAX in the same strain of Saccharomyces cerevisiae with deletions of selected mitochondrial proteins that have been implicated in the function of BCL 2 family members . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We observed baseline expression of the anti apoptotic Mcl 1 and pro apoptotic Bax proteins in immunoblots of eosinophil lysates , but not Bcl 10 , Bcl 2 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The expressions of Bax and Bcl 10 were stronger in umbilical artery than in the neonatal aorta , but Bcl 2 was weak in both arteries in immunohistochemistry . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Caspases are known to cleave Bid , a proapoptotic family member , as well as Bcl 2 and Bcl 10 ( L ) , two prosurvival family members , which activate their cytotoxic activity resulting in the release of cytochrome c from mitochondria . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We have analyzed the interleukin 4 ( IL 4 ) triggered mechanisms implicated in cell survival and show here that IL 4 deprivation induces apoptotic cell death but does not modulate Bcl 2 or Bcl 10 expression . ^^^ Since Bcl 10 expression is insufficient to ensure cell survival in the absence of IL 4 , we speculate that additional molecules replace the antiapoptotic role of Bcl 2 and Bcl 10 in an alternative IL 4 triggered pathway . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Loss of outer membrane permeability ( 1 ) results in the accumulation of stored metabolic energy within the intermembrane space in the form of creatine phosphate , ( 2 ) is prevented by the outer mitochondrial membrane proteins Bcl 10 ( L ) and Bcl 2 , and ( 3 ) can be reversed by growth factor readdition . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
To investigate the molecular pathway to apoptosis induction , members of the Bcl 2 family of proteins were examined ( Bcl 2 , Bcl 10 , Bax , and Bak ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Immunohistochemical detection of Bcl 2 in Kaposi ' s sarcoma lesions varies according to histopathologic stage , whereas expression of Bcl 10 and Mcl 1 differs according to human immunodeficiency virus serologic status of patients . ^^^ Expression of Bcl 2 , Bcl 10 , and Mcl 1 was immunohistochemically evaluated in 33 cases of Kaposi ' s sarcoma ( KS ) of the skin . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Pro apoptotic apoptosis protease activating factor 1 ( Apaf 1 ) has a cytoplasmic localization distinct from Bcl 2 or Bcl 10 ( L ) . ^^^ Whereas Bcl 2 and Bcl 10 ( L ) were prominent on organelle membranes , endogenous Apaf 1 was cytosolic and did not colocalize with them , even when these pro survival proteins were overexpressed or after apoptosis was induced . ^^^ After the death stimuli , Bcl 2 and Bcl 10 ( L ) precluded the release of the Apaf 1 cofactor cytochrome c from mitochondria and the formation of larger Apaf 1 complexes , which are steps that presage apoptosis . ^^^ However , neither Bcl 2 nor Bcl 10 ( L ) could prevent the in vitro activation of Apaf 1 induced by the addition of exogenous cytochrome c . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Variant forms of p 18 Bax alpha and p 16 Bcl 10 ( L ) were generated with the down regulation of both Bax alpha ( p 21 ) and Bcl 10 ( L ) ( p 31 ) at 36 and 48 h following CBDCA stimulation , suggesting that the modulation of Bcl 2 family proteins Bax alpha and Bcl 10 ( L ) play some role in CBDCA mediated apoptosis . ^^^ The pretreatment of cells with pan caspase inhibitor Z VAD fmk markedly prevented CBDCA mediated cytotoxicity / apoptosis and the modulation of Bcl 2 family proteins ( generation of p 18 Bax alpha and p 16 Bcl 10 ( L ) ) with only slight prevention of decline of Deltapsi ( m ) . ^^^ Taken together , these results may suggest that activation of several caspases , including caspase 3 and 8 , plays some role in CBDCA mediated apoptosis , probably through the modification of Bcl 2 family proteins , Bax alpha and Bcl 10 ( L ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The antiapoptotic Bcl 2 and Bcl 10 ( L ) proteins of mammals are converted into potent proapoptotic factors when they are cleaved by caspases , a family of apoptosis inducing proteases ( E . ^^^ However , unlike the caspase cleavage products of cellular Bcl 2 , Bcl 10 ( L ) , and Bid , which are potent inducers of apoptosis , the cleavage product of gammaHV 68 Bcl 2 lacked proapoptotic activity . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In addition , immunohistochemistry was performed for an array of apoptosis related proteins , i . e . the recently described apoptosis specific protein cJun / AP1 ( ASP ) , the proto oncogenes c Jun , c Jun AP 1 , Bcl 2 , Bax , Bcl 10 , p 53 , CD 95 ( Fas / Apo 1 ) , activated caspase 3 , several heat shock proteins ( alpha B crystallin , ubiquitin ) , and alpha synuclein . ^^^ There were no significant differences in the expression of c Jun , ASP , Bcl 2 , Bax , and Bcl 10 in substantia nigra neurons between PD , DLB , and controls nor between cortical and subcortical neurons with and without Lewy bodies . ^^^ No expression of p 53 , and activated caspase 3 , or any of the examined stress proteins was seen in neurons , while reactive astroglia and microglia were decorated by antibodies to Bcl 2 , Bax , alpha B crystallin and less , to Bcl 10 and caspase 3 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 , bax , bcl 10 ( L ) and bcl 10 ( S ) expression in neoplastic and normal cervical tissue . ^^^ We simultaneously assessed bcl 2 , bax , bcl 10 ( L ) and bcl 10 ( S ) expression levels by Western blotting on 53 primary untreated cervical cancers and 15 normal samples . ^^^ Bcl 2 showed a trend to be lower in neoplastic than in normal samples ( P < 0 . 01 ) , while no significant difference was observed for bax and bcl 10 ( L ) . ^^^ Interestingly , in cervical cancer , bcl 2 and bcl 10 ( L ) were directly correlated ( P < 0 . 01 ) . ^^^ Bcl 2 , bax and bcl 10 ( L ) levels in responding and non responding patients were not differently distributed . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
This is opened by pro apoptotic members of the Bcl 2 family such as BAX and prevented by anti apoptotic members such as Bcl 10 ( L ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
RIP 3 mediated apoptosis was inhibited by Bcl 2 , Bcl 10 ( L ) , dominant negative FADD , as well as the general caspase inhibitor Z VAD . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Induction of apoptosis in leukemic cells by the reversible microtubule disrupting agent 2 methoxy 5 ( 2 ' , 3 ' , 4 ' trimethoxyphenyl ) 2 , 4 , 6 cycloheptatrien 1 one : protection by Bcl 2 and Bcl 10 ( L ) and cell cycle arrest . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The Bcl 2 family protein BAD promotes apoptosis by binding through its BH 3 domain to Bcl 10 ( L ) and related cell death suppressors . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
IL 4 dependent induction of BCL 2 and BCL 10 ( L ) IN activated T lymphocytes through a STAT 6 and pi 3 kinase independent pathway . ^^^ The pleiotropic cytokine interleukin ( IL ) 4 plays an important role in the maintenance of activated T cells , perhaps reflecting induction of the anti apoptotic genes Bcl 2 and Bcl 10 ( L ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Endogenous and exogenous fibroblast growth factor 2 support survival of chick retinal neurons by control of neuronal neuronal bcl 10 ( L ) and bcl 2 expression through a fibroblast berowth factor receptor 1 and ERK dependent pathway . ^^^ Exogenous FGF 2 supported neuronal survival after serum deprivation and increased neuronal bcl 10 ( L ) and bcl 2 expression , through binding to its receptor R 1 ( FGF R 1 ) , and subsequent extracellular signal regulated kinase ( ERK ) activation . ^^^ Its down regulation by antisense oligonucleotides and blockade of its signaling pathway ( binding to FGF R 1 , tyrosine phosphorylation , and ERK inhibition ) decreased bcl 10 ( L ) and bcl 2 levels and and enhanced apoptosis , suggesting that endogenous FGF 2 supported neuronal survival through a pathway similar to that of exogenous FGF 2 . ^^^ This pathway may serve to up regulate , or maintain , bcl 10 ( L ) and bcl 2 levels that normally decrease during the onset of apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
These cells showed a similar cardiolipin content and expressed the same level of anti apoptotic proteins Bcl 2 and Bcl 10 ( L ) as APO S unsorted cells but contained significantly higher concentration of the antioxidant glutathione . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Using immunohistochemical techniques and Western blot analysis , the possible role of Bcl 2 family members Bax , Bcl 2 , Bcl 10 ( s ) , and Bcl 10 ( l ) in male germ cell density related apoptosis and DNA damage induced apoptosis was studied . ^^^ Furthermore , as Bcl 10 ( l ) , but not Bcl 2 , is present in spermatogonia and spermatocytes , Bcl 10 ( l ) may regulate germ cell density , possibly in cooperation with Bax . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
To determine the role of bcl 2 , bcl 10 and bax in melanocytic tumors we investigated the differential expression of these genes via RT PCR in tissue samples from human benign nevi , primary melanomas and melanoma metastases in comparison with normal skin . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
When p 53 , c Myc , Bcl 2 , Bcl 10 ( L ) , and Bax were measured by flow cytometry and the activities of caspase 1 and caspase 3 like protease determined with Ac YVAD AMC or Ac DEVD AMC as substrates , the profile of ROS induced changes in these apoptosis regulatory and effector proteins suggests that elevation of c Myc , p 53 , and Bax and activation of caspase 3 play an important role in the apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Mitochondrial function , that is , incorporation of 3 , 3 ' dihexyloxacarbocyanine iodide [ DiOC ( 6 ) ( 3 ) ] and generation of reactive oxygen species ( ROS ) as well as expression of c Myc and Bcl 2 family members ( Bcl 2 , Bcl 10 ( L ) , Bax ) were evaluated by multiparameter flow cytometry . ^^^ Moreover , Bax protein was overexpressed in postG ( median fluorescence intensity = 180 , range 168 186 ) compared with preG cultures ( median fluorescence intensity = 75 , range 68 80 ; p < 0 . 01 ) , while no differences in Bcl 2 , Bcl 10 ( L ) , and c Myc staining intensity were observed . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Furthermore , Bcl 2 and Bcl 10 ( L ) , which protect tumor cells from most forms of apoptosis , failed to rescue breast cancer cells from asHsp 70 induced death . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Moreover , these cells showed high levels of BCL 2 and BCL 10 ( L ) expression . ^^^ The cohort of BCR / ABL expressing cells resistant to apoptosis induced by DM BAD showed only high levels of BCL 2 and BCL 10 ( L ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
These proteins were tested for increased transcription from the human Bcl 2 and Bcl 10 ( L ) promoters . ^^^ Whereas no effect was observed on the Bcl 2 promoter , both Tax 1 and Tax 2 increased transcription of the Bcl 10 ( L ) promoter in T cells , although Tax 1 appeared to be more efficient than Tax 2 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Further supporting an apoptotic mechanism , expression of the antiapoptotic Bcl 2 and Bcl 10 proteins was increased following H / R . ^^^ At the same time , expression of mutated lkappaB prevented the increased expression of endogenous Bcl 2 and Bcl 10 . ^^^ These findings suggest a pathway where NFkappaB activation induces overexpression of Bcl 2 and Bcl 10 , which function to prevent apoptotic cell death following H / R treatments . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The degree of apoptosis was analyzed in relation to several clinicopathologic parameters , cell proliferative activity , and immunohistochemical expression of apoptosis related proteins , including bcl 2 , bax , bcl 10 , bak , p 53 , p 21 ( WAF1 / CIP1 ) , Fas , and Fas ligand . ^^^ Many synovial sarcomas were diffusely positive for bcl 2 family proteins ( bcl 2 , bax , bcl 10 , and bak ) and were negative or only sporadically positive for Fas , Fas ligand , p 53 , and p 21 ( WAF1 / CIP1 ) proteins . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Microtubule damaging agents arrest cells at G ( 2 ) / M and induce apoptosis in association with phosphorylation of the anti apoptotic proteins Bcl 2 and Bcl 10 ( L ) . ^^^ Because microtubule inhibitors activate JNK , we sought to determine whether JNK was responsible for Bcl 2 / Bcl 10 ( L ) phosphorylation in KB 3 cells treated with vinblastine . ^^^ In addition , AS JNK1 / 2 inhibited vinblastine induced phosphorylation of Bcl 2 by 85 % and that of Bcl 10 ( L ) by 65 % . ^^^ Stable expression of the JNK scaffold protein JIP 1 blocked vinblastine induced phosphorylation of c Jun and ATF 2 , but did not affect Bcl 2 / Bcl 10 ( L ) phosphorylation , confirming a bifurcation in JNK signaling involving both nuclear and non nuclear substrates . ^^^ These results provide evidence for a direct role of the JNK pathway in apoptotic regulation through Bcl 2 / Bcl 10 ( L ) phosphorylation . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Transgenic animal models and expression studies have shown that caspases , Bcl 2 , Bax , and possibly Bcl 10 are necessary players for the control of programmed cellular death in retinal ganglion cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
CSF 1 maintained NF kappaB activation and increased the expression of bcl 2 and bcl 10 ( L ) mRNA , but had no effect on JNK activation . ^^^ In contrast , OPGL enhanced both NF kappaB and JNK kinase activation and increased the expression of c src , but not bcl 2 and bcl 10 ( L ) mRNA . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 and Bcl 10 ( L ) belong to a family of proteins overexpressed in a variety of human cancers which inhibit apoptosis in response to a number of stimuli including chemotherapeutic agents and ionizing radiation . ^^^ Although Bcl 2 and Bcl 10 ( L ) overexpression resulted in inhibition of radiation induced apoptosis , it did not result in enhanced clonogenic survival . ^^^ Consistent with this was the observation that Bcl 2 and Bcl 10 ( L ) protected cells from DNA fragmentation , loss of mitochondrial membrane potential , and caspase activation for up to 72 hours after irradiation . ^^^ Beyond 72 hours , there was a rapid loss in the ability of Bcl 2 and Bcl 10 ( L ) to inhibit these markers of apoptosis . ^^^ These results provide a molecular basis for the observation that expression of Bcl 2 or Bcl 10 ( L ) is not a prognostic marker of tumor response to cancer therapy . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The gene expressions of c met and the anti apoptotic bcl 2 family , including bcl 2 , bcl 10 ( L ) and bcl w , were analysed in human colorectal adenomas and adenocarcinomas by using a quantitative polymerase chain reaction combined with reverse transcription . ^^^ The bcl w , bcl 2 and bcl 10 ( L ) genes were over expressed in nine , five and six of 12 adenomas and in five , two and seven of 11 carcinomas , respectively . ^^^ The c met mRNA level in human colorectal adenomas and carcinomas was correlated with bcl w but not with bcl 2 or with bcl 10 ( L ) mRNA level . ^^^ On the other hand , the gene expression of bcl 2 or bcl 10 ( L ) was not affected by treatment with c met antisense oligonucleotides . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Analysis of bcl 2 family gene transfectants revealed a down regulation of TNF induced apoptosis by bcl 2 and bclX overexpression , and an up regulation by bax gene . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Because Bcl 2 family members are known to affect the redox status of the cell , we examined the effect of Bcl 10 ( L ) expression on TNF signaling . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
A detailed study on bcl 2 superfamily gene expression shows that TGF beta produces a decrease in the messenger RNA ( mRNA ) and protein levels of bcl 10 ( L ) , an antiapoptotic member of this family , capable of preventing cytochrome c release . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The expression of Bcl 2 , Bcl 10 ( L ) , and Bax was evaluated in both cell types by Western blot analysis . ^^^ C 6 glioma cells strongly expressed Bcl 10 ( L ) and only weakly expressed Bcl 2 and Bax , whereas SY5Y neuroblastoma cells expressed lower levels of Bcl 10 ( L ) and higher levels of both Bcl 2 and Bax . ^^^ Collectively , these results suggest that higher constitutive expression of Bcl 10 ( L ) , rather than Bcl 2 , correlates with resistance to DNB induced MPT in SY5Y and C 6 cells and that differential regulation of the permeability transition pore may underlie the cell specific neurotoxicity of DNB . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Mcl 1 , Bcl 2 , Bcl 10 ( L ) , and glutathione S transferase ( GST ) expression were increased in a time dependent manner after heat shock . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The present study examined the expression of some Bcl 2 family members , including Bcl 2 , Bcl 10 ( L ) , Mcl 1 , and Bax , in response to cytokine stimulation in TF 1 and JYTF 1 cells in which SCF costimulation is differentially required for optimal proliferation . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Expression of Bcl 10 ( L ) and Bid decreased significantly in the cadmium treated cells , although no apparent change in Bcl 2 and Bax expression was found . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Deparaffinized tissue sections from 22 OLP and 10 control oral biopsy specimens were immunohistochemically stained with anti Bcl 2 , anti Bcl 10 , anti Bax and anti TNF alpha antibodies . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Disrupted mitochondrial electron transport function increases expression of anti apoptotic bcl 2 and bcl 10 ( L ) proteins in SH SY5Y neuroblastoma and in Parkinson disease cybrid cells through oxidative stress . ^^^ Whether cells activate programmed death ( apoptosis ) pathways derives , in part , from relative activities of proteins such as bcl 2 and bcl 10 ( L ) , that have anti apoptotic actions . ^^^ We studied the responses of bcl 2 and bcl 10 ( L ) genes in pharmacologic ( acute incubation with methylpyridinium ( MPP+ ) ) and mitochondrial transgenic ( `` cybrid ' ' ) models of Parkinson disease C 1 defects . ^^^ MPP+ incubation increased levels of bcl 2 and bcl 10 ( L ) proteins in native SH SY5Y cells but not in rho ( 0 ) cells devoid of ETC activity . ^^^ PD cybrids showed increased basal levels of bcl 2 and bcl 10 ( L ) proteins , similar to the maximum levels found after MPP+ treatment of control SY5Y cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
MEK / ERK signaling pathway regulates the expression of Bcl 2 , Bcl 10 ( L ) , and Mcl 1 and promotes survival of human pancreatic cancer cells . ^^^ RESULTS : Herein , we showed that inhibition of ERK1 / 2 activities caused ( 1 ) a G 1 arrest ; ( 2 ) a down regulation of the expression levels of the anti apoptotic homologs Bcl 2 , Mcl 1 , and Bcl 10 ( L ) without affecting the pro apoptotic levels of Bax and Bak ; ( 3 ) a promotion of caspases 3 , 6 , 8 , and 9 activities ; ( 4 ) a stimulation of PARP cleavage ; and ( 5 ) a programmed cell death by apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In studies of apoptosis associated proteins , BMP 2 was seen to down regulate the expression of Bcl 10 ( L ) ; however , BMP 2 had no effects on the expression of Bcl 2 , Bax , or Bad . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
CGP57148B treatment down regulated antiapoptotic XIAP , cIAP 1 , and Bcl 10 ( L ) , without affecting Bcl 2 , Bax , Apaf 1 , Fas ( CD 95 ) , Fas ligand , Abl , and Bcr Abl levels . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Antiapoptotic bcl 2 mRNA content was decreased in all drug resistant cell variants , the level of bcl 10 ( L ) mRNA was greatly diminished only in one of cell lines , K 562 VP16 1 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In MCF 7 , an increase in Bad and Bax protein expression and a decrease in Bcl 10 ( L ) protein and Bcl 2 protein and mRNA were observed . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Immunohistologic analyses revealed that Bcl 2 and Bcl 10 were preferentially expressed in salivary infiltrating mononuclear cells more than acinar and ductal epithelial cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Among the bcl 2 family members , bcl 2 , bcl w , and bcl 10 ( L ) were also differently expressed in these two cell lines . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
BAD , a proapoptotic member of the bcl 2 gene family , is rapidly dephosphorylated after injury , dissociates from 14 3 3 in the cytosol , and translocates to the mitochondria of neurons where it binds to Bcl 10 ( L ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
During the leukemic phases , the clonal cells were activated blasts expressing elevated levels of wild type ( wt ) p 53 , Bcl 2 , Bcl 10 ( L ) , and Bax , while Bak expression increased during the decline of lymphocytosis . ^^^ Bax heterodimerized with Bcl 2 but not with Bcl 10 ( L ) . ^^^ The elevation in Bcl 2 , Bcl 10 ( L ) and Bax expression during early leukemic phases seems to result from cell activation since a similar increase was induced by activating the remission phase leukemic cells in culture . ^^^ The data suggest that wt p 53 , Bcl 10 ( L ) , and Bcl 2 / Bax heterodimers support the accumulation of activated leukemic cells during the leukemic phases , while Bax and Bak may be involved in their decline during regression . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Finally , we observed constitutive expression of both antiapoptotic factors bcl 2 and bcl 10 , the former having increased expression upon WC 1 stimulation . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In 56 specimens [ CCH , n=1 ; MTC with CCH , n=26 ; MTC , n=20 ; lymph node metastasis ( LNM ) , n=9 ] from 46 patients [ multiple endocrine neoplasia type 2a ( MEN2a ) , n=24 ; MEN2b , n=2 ; familiar MTC ( FMTC ) , n=4 ; sporadic MTC , n 16 ] and 3 cases of non neoplastic CCH , proliferation activity ( MIB 1 ) , the rate of apoptosis [ dUTP nick end labelling ( TUNEL ) ] and expression of p 53 , bcl 2 , bcl 10 and bax were investigated and compared with clinical data . ^^^ In MEN associated CCH and small MTC , bcl 2 was strongly expressed , bcl 10 was moderately expressed and bax was only weakly expressed . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Heterodimerization of Bcl 2 and Bcl 10 ( L ) with Bax and Bad in colorectal cancer . ^^^ The rate of cell loss owing to apoptosis is mediated by competitive dimerization with selective pairs of cell death antagonists ( Bcl 2 , Bcl 10 ( L ) ) and agonists ( Bax , Bad ) . ^^^ We analyzed the expression of Bcl 2 , Bcl 10 ( L ) , Bax , and Bad in normal appearing mucosa and colorectal tumor tissues by Western blotting after immunoprecipitation . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Under hypoxic conditions , phenylephrine prevented the down regulation of Bcl 2 and Bcl 10 mRNA / protein and induced hypertrophic growth . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Furthermore , 16K hPRL increased the conversion of Bcl 10 to its proapoptotic form , suggesting that the Bcl 2 protein family may also be involved in 16K hPRL induced apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 10 is a member of the Bcl 2 family and has been suggested to be important for the survival and maturation of various cell types including the erythroid lineage . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The release of cytochrome c can be influenced by different Bcl 2 family member proteins , including , but not limited to , Bax , Bid , Bcl 2 , and Bcl 10 ( L ) . ^^^ Bax and Bid potentiate cytochrome c release , whereas Bcl 2 and Bcl 10 ( L ) antagonize this event . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The Bcl 10 ( L ) and Bcl 10 ( S ) mRNAs were less consistently upregulated and there was no evidence for upregulation of Fas or Bcl 2 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Consistent with this , overexpressing active Akt rescues cells from apoptosis without altering expression levels of endogenous Bcl 2 , Bcl 10 , or Bax . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We studied the expression of several genes involved in differentiation , apoptosis and chemoresistance : ets 1 , bax , bcl 2 , bag 1 , bcl 10 , mdr 1 and mrp . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We therefore evaluated the expression of proteins promoting cell survival , such as bcl 2 , bcl 10 ( l ) and cyclin dependent kinase inhibitors , on muscle biopsies from 14 patients with polymyositis , dermatomyositis , inclusion body myositis and HIV associated myositis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
IFN gamma increased BAK protein levels and decreased Bcl 2 and Bcl 10 ( S ) protein levels in TSGH 9201 cells . ^^^ IFN gamma mediated apoptosis was associated with the alteration in protein levels of Bcl 2 , Bcl 10 ( S ) and BAK . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Immunohistochemical stains for cytokeratins , involucrin , and apoptosis related proteins such as Bcl 2 , Bcl 10 ( L ) , and Bax were done . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Western blot analysis revealed that the content of Bcl 10 ( L ) ( but not of Bcl 2 , BAX , Bad , and Bim ) significantly decreased in thymocytes after CLP . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Neural precursor cell apoptosis was also unaffected by targeted disruptions of Bclx and Bcl 2 , and unlike neurotrophic factor deprivation induced neuronal apoptosis , was not associated with a detectable loss of cytochrome c from mitochondria . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The resistance of U 266 cells to anti Fas did not appear to reflect dysregulation of Bcl 2 , Bcl 10 ( L ) , and Bax , because these proteins were expressed in both RPM 18226 and U 266 cells to similar levels . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Overexpression of the anti apoptotic proteins Bcl 2 or Bcl 10 ( L ) that blocked loss of the mitochondrial membrane potential and cytochrome c release from mitochondria also conferred resistance to BetA . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We demonstrated that E ( 2 ) increased the antiapoptotic proteins , bcl 2 and bclx ( L ) , whereas , the progestins drastically decreased bcl 2 expression and weakly bclx ( L ) levels . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Although spontaneous apoptosis of the clonal Th 2 cells was clearly associated with down regulation of both bcl 2 and bcl 10 ( L ) levels , IFN alpha had no significant effect on the expression of these antiapoptotic proteins , whereas addition of IL 2 resulted in higher levels of bcl 2 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Nef reduces the expression of the anti apoptotic proteins Bcl 2 and Bcl 10 ( L ) and induces a striking enhancement of apoptotic hallmarks , including mitochondrial depolarization , exposure of phosphatidylserine on the cell surface , activation of caspase 3 , and cleavage of the caspase target poly ( ADP ribose ) polymerase . ^^^ An increased apoptotic response and down modulation of Bcl 2 / Bcl 10 ( L ) following Nef expression are observed also in NIH 3T3 fibroblasts . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We further analyzed the pattern of BCL 2 and BCL 10 ( L ) expression and their coexpression with BCL 6 in normal thymus and T LBL and compared it to that of follicle centers of reactive lymph nodes and follicular lymphoma . ^^^ BCL 6 ( + ) cortical thymocytes coexpressed BCL 10 ( L ) but not BCL 2 . ^^^ All 4 BCL 6 ( + ) T LBLs and 4 BCL 6 ( ) T LBLs coexpressed BCL 2 and BCL 10 ( L ) . ^^^ The pattern of BCL 6 , BCL 2 , and BCL 10 ( L ) expression in cortical thymocytes is highly reminiscent of germinal centers , and the abnormal coexpression of BCL 2 , BCL 10 ( L ) , and BCL 6 in T LBL is analogous to coexpression in follicle center cell lymphomas , suggesting that coexpression of these anti apoptotic genes may contribute to the pathogenesis of T LBL . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Neuronal Ras was constitutively active and a corresponding activating phosphorylation of mitogen activated kinase was observed , but there were no changes in the activity of phosphoinositide 3 kinase , the phosphorylation of its target kinase Akt / PKB , or expression of the anti apoptotic proteins Bcl 2 or Bcl 10 ( L ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Because cell survival and apoptosis are regulated , in part , by the relative abundance of proteins of the Bcl 2 family , we hypothesized that lung cells dying during exposure would show increased expression of pro apoptotic members , such as Bax , whereas surviving cells would have increased expression of anti apoptotic members , such as Bcl 10 ( L ) . ^^^ The hypothesis is tested in the current study by determining which Bcl 2 genes are regulated by hyperoxia , with specific focus on correlating expression of Bax and Bcl 10 ( L ) with morphologic evidence of apoptosis or necrosis . ^^^ Adult mice exposed to greater than 95 % oxygen concentrations for 48 to 88 hours had increased whole lung mRNA levels of Bax and Bcl 10 ( L ) , no change in Bak , Bad , or Bcl 2 , and decreased levels of Bcl w and Bfl 1 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Both anti apoptotic ( Bcl W , Bcl 10 ( L ) ) and pro apoptotic ( Bad , Bak , Bax ) members of the Bcl 2 family were expressed in developing skeletal muscle in vivo . ^^^ Loss of Bcl 2 did not affect expression of other family members , because neonatal muscles of wild type and Bcl 2 null mice had similar amounts of Bcl 10 ( L ) , Bcl W , Bad , Bak , and Bax mRNAs . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Targeted disruption of bcl 10 ( L ) , an antiapoptotic bcl 2 gene family member , causes massive death of immature neurons in the developing nervous system whereas disruption of caspase 9 , a proapoptotic caspase gene family member , leads to decreased neuronal apoptosis and neurodevelopmental abnormalities . ^^^ To examine Bcl 2 and Caspase family dependent apoptotic pathways in telencephalic neurons , we compared the effects of cytosine arabinoside ( AraC ) , a known neuronal apoptosis inducer , on wild type , Bcl 10 ( L ) , Bax , Caspase 9 , Caspase 3 , and p 53 deficient telencephalic neurons in vitro . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We have compared the roles of two anti apoptotic members of the Bcl 2 family , Bcl w and Bcl 10 ( L ) , in regulating the survival of sensory neurons during development . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In both cases , the absence of JunB expression results in increased numbers of granulocyte progenitors , which display enhanced GM CSF mediated proliferation and extended survival , associated with changes in the expression levels of the GM CSFalpha receptor , the anti apoptotic proteins Bcl 2 and Bclx , and the cell cycle regulators p 16 ( INK4a ) and c Jun . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The antiapoptotic proteins , Bcl 2 and Bcl 10 ( L ) , are expressed in most cases of acute myeloid leukemia ( AML ) and may contribute to drug resistance in AML . ^^^ We tested Bcl 2 AS in myeloid leukemic HL 60 cells , in Bcl 2 and Bcl 10 ( L ) overexpressing HL 60 DOX cells , and in primary AML samples . ^^^ The expression of other antiapoptotic proteins ( Bcl 10 ( L ) , Bag 1 , A 1 , and Mcl 1 ) did not prevent Bcl 2 AS induced apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Since the Bcl 2 family of proteins constitutes a critical checkpoint in apoptosis , acting upstream of the apoptotic machinery , we investigated the expression of six Bcl 2 homologs ( Bcl 2 , Bcl 10 ( L ) , Mcl 1 , Bax , Bak , Bad ) and one non homologous associated molecule ( Bag 1 ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Changes in the generation of reactive oxygen species and in mitochondrial membrane potential during apoptosis induced by the antidepressants imipramine , clomipramine , and citalopram and the effects on these changes by Bcl 2 and Bcl 10 ( L ) . ^^^ Overexpression of the antiapoptotic protein Bcl 2 or Bcl 10 ( L ) prevents antidepressant induced apoptosis , as well as loss of DeltaPsi ( m ) , but does not affect the generation of ROS . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Taken together , these results indicate that this glucocorticoid exerts a protective role on cell survival and it delays apoptosis of human and rat hepatocytes by modulating caspase 3 like protease activity and bcl 2 and bcl 10 gene expression . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Akt activation by proapoptotic stimuli lay upstream of mitochondria , because neither caspase inhibitors nor overexpression of Bcl 2 or Bcl 10 ( L ) could prevent it . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
METHODS AND RESULTS : For immunohistochemistry , tissue sections of 32 patients were treated with an antigen retrieval METHOD : Primary antibodies against the apoptosis related proteins , bcl 2 , bcl 10 , bax , and bak were applied . ^^^ Among the bcl 2 family , bcl 2 was the most ubiquitously expressed protein in ameloblastomas , while bcl 10 was expressed in the greatest concentrations . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The protein encoded by PUMA was found to be exclusively mitochondrial and to bind to Bcl 2 and Bcl 10 ( L ) through a BH 3 domain . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
ATF 3 strongly downregulated CRE dependent transcription , while ATF 3 did not affect the expression levels of Bcl 2 , Bcl 10 , or Bax . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Helenalin triggers a CD 95 death receptor independent apoptosis that is not affected by overexpression of Bcl 10 ( L ) or Bcl 2 . ^^^ We show here that the sesquiterpene lactone helenalin ( 10 50 microM ) induces apoptosis in leukemia Jurkat T cells even if they lack the CD 95 death receptor or overexpress the antiapoptotic proteins Bcl 10 ( L ) or Bcl 2 . ^^^ Most importantly , overexpression of the mitochondria protecting proteins Bcl 10 ( L ) or Bcl 2 failed to confer resistance to helenalin induced apoptosis , although the data presented here suggest that helenalin induces a mitochondria dependent pathway . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Apoptosis induced in the IL 3 dependent murine pro B lymphocytic ( FL5 . 12 ) cell line by the 5 lipoxygenase activating protein inhibitor MK 886 is accompanied by the rapid loss of the anti apoptotic bcl 10 ( L ) and bcl 2 , but not the proapoptotic bax proteins ( Datta et al . , J . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Western blotting analysis and flow cytometric studies revealed that HGF inhibited doxorubicin and etoposide induced decreases in the levels of the anti apoptotic proteins Bcl 10 ( L ) , and to a lesser extent Bcl 2 , without inducing changes in the pro apoptotic Bax protein . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In this study , we demonstrate that IFN gamma induces apoptosis in WEHI 279 mouse B cells and IL 7 dependent mouse pre B cells by disrupting mitochondrial membrane potential and cytochrome c release via down regulation of Bcl 2 and Bcl 10 ( L ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Activation of the PI3K pathway through mp110 * ER failed to up regulate expression of the c myc , cyclin D 2 , cyclin D 3 , cyclin E , bcl 2 , or bcl 10 ( L ) genes or down regulate expression of p 27 ( Kip 1 ) , even when coactivated with the Janus kinases ( Jak ) or the Raf / Erk pathway . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Additionally , U 69593 increased the content of the anti apoptotic members of the Bcl 2 family of proteins , the Bcl 2 and Bcl 10 ( L ) , whereas it had no significant effect on the apoptosis promoting homologues Bax , Bcl 10 ( S ) and Bak . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The bcl 10 gene is a member of the bcl 2 family of genes that regulate apoptosis , and gives rise to two proteins , Bcl XL and Bcl XS , via alternative mRNA splicing . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In contrast to BCL 2 , BCL 10 ( L ) , 10 linked inhibitor of apoptosis protein ( XIAP ) and FLICE inhibitory protein ( FLIP ) , the levels of the cyclin dependent kinase ( CDK ) inhibitor , p21Waf / Cip1 , rapidly decreased in response to CHX . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Proteins of the Bcl 2 family regulate apoptosis , some antagonizing cell death and others , such as Bcl 10 ( S ) , promoting it . ^^^ The anti apoptotic agents Bcl 2 and Bcl 10 ( L ) , the caspase inhibitor Z VAD FMK , and nerve growth factor ( NGF ) did not prevent Bcl 10 ( S ) localization to the mitochondria , and did not require the BH 4 or the loop domains of Bcl 10 ( S ) for their survival effect . ^^^ Bcl 10 ( S ) is capable of forming homodimers with itself and heterodimers with Bcl 10 ( L ) or Bcl 2 . ^^^ Accordingly co expression of Bcl 10 ( S ) DeltaTM with Bcl 10 ( S ) , Bcl 2 , or Bcl 10 ( L ) leads to a change in the subcellular distribution of Bcl 10 ( S ) DeltaTM , from a diffuse distribution throughout the cell to a more defined distribution . ^^^ Moreover co immunoprecipitation experiments directly demonstrated that Bcl 10 ( S ) can associate with GFP Bcl 10 ( S ) , Bcl 10 ( L ) , or Bcl 2 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Using mid gestation human jejunum and colon organotypic cultures , we analyzed the impact of growth factors ( namely insulin ; 10 microg / ml ) and pharmacological compounds that inhibit signal transduction molecules / pathways ( namely tyrosine kinases , Fak , P 13 K / Akt , and MEK / Erk ) on cell survival and Bcl 2 homolog expression ( anti apoptotic : Bcl 2 , Bcl 10 ( L ) , Mcl 1 ; pro apoptotic : Bax , Bak , Bad ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Specifically , this report examined expression of apoptotic promoters Bax and Bad and apoptotic inhibitors Bcl 2 and Bcl 10 ( all members of the Bcl 2 protein family ) . ^^^ Expression of Bcl 2 , Bcl 10 , Bax , and Bad and the extent of apoptosis were determined by flow cytometric analysis of freshly isolated cells and cells cultured with TGF beta ( 1 ) and FL effectors . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In this study , phosphatase inhibitor okadaic acid induces apoptosis in U 937 cells via a mechanism that appears to involve caspase 3 activation , but not modulation of Bcl 2 , Bax , and Bcl 10 ( L ) expression levels . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In contrast , APRIL does not regulate the expression levels of the antiapoptotic proteins FLICE inhibitory protein ( FLIP ) , Bcl 2 or Bcl 10 ( L ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Reverse transcription polymerase chain reaction analysis revealed that up regulation of the anti apoptotic genes for Bcl 2 , Bcl 10 , and manganese superoxide dismutase was observed in PEDF treated immature but not mature neurons . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
This cell death is partially dependent on caspase activity , independent of estrogen receptors , and does not result in a significant loss of Bcl 2 or Bcl 10 ( L ) protein . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The increased expressions of Bax and Bad were detected in HAECs incubated for 24 h with gly ox HDL , but gly ox HDL failed to interfere with the expression of Bcl 2 and Bcl 10 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
IL 10 decreased expression of bcl 2 , bcl 10 ( L ) , and mcl 1 but not bax mRNA in monocytes stimulated with GM CSF . ^^^ Addition of IL 10 after that time induced neither apoptosis nor a decrease in expression of bcl 2 , bcl 10 ( L ) , and mcl 1 mRNA . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Moreover , Bid cleavage precedes the initial cytochrome c release , whereas the late , amplified cytochrome c release coincides with changes in levels of Bcl 2 , Bcl 10 ( L ) , and reduction of mitochondrial membrane potential . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 , Bcl 10 , and Bax expression by immunohistochemistry in inclusion body myositis : a study of 27 cases . ^^^ CONTEXT : Bcl 2 , Bcl 10 , and Bax are among the variety of proteins that have been described as being involved in the regulation of apoptotic cell death . ^^^ Bcl 2 and Bcl 10 ( L ) inhibit apoptosis , and Bax is proapoptotic . ^^^ OBJECTIVE : To evaluate the expression of Bcl 2 , Bcl 10 , and Bax in inclusion body myositis ( IBM ) . ^^^ We examined muscle specimens from 27 patients ( 17 men , 10 women ) with IBM to evaluate Bcl 2 , Bcl 10 , and Bax expression by immunohistochemistry . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
METHODS : We investigated the expression of Bcl 2 , Bcl 10 , and Bax using immunohistochemistry in 86 ESCCs , and scored the expression by the weighted score . ^^^ The inverse relationship between Bcl 2 and Bcl 10 expression was detected ( P = 0 . 001 ) , while the positive one between Bcl 10 and Bax expression was detected ( P = 0 . 014 ) . ^^^ CONCLUSION : These results imply that Bcl 2 family proteins , especially Bcl 10 , may contribute to the progression in ESCC . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Survival factor induced phosphorylation of Bad results in its dissociation from Bcl 10 ( L ) but not Bcl 2 . ^^^ The pro apoptotic Bcl 2 family protein Bad heterodimerizes with Bcl 2 and Bcl 10 ( L ) in the outer mitochondrial membranes , nullifying their anti apoptotic activities and promoting cell death . ^^^ We report that interleukin 3 ( IL 3 ) stimulation induces Bad phosphorylation and triggers its translocation from mitochondria to cytoplasm in cells expressing Bcl 10 ( L ) but not Bcl 2 . ^^^ Overexpression of Bad sensitized Bcl 10 ( L ) expressing FL5 . 12 cells to apoptosis induced by IL 3 deprivation , but had no effect on the viability of cells expressing Bcl 2 . ^^^ When the N terminal regions of Bcl 2 and Bcl 10 ( L ) were swapped with each other , the Bcl 10 ( L ) ( N ) Bcl 2 chimaeric protein ( containing the N terminal region of Bcl 10 ( L ) ) failed to prevent Bad phosphorylation in cells and was unable to block the cytosolic distribution of this pro apoptotic protein . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
BCL 2 , BCL 10 ( L ) sequester BH 3 domain only molecules preventing BAX and BAK mediated mitochondrial apoptosis . ^^^ Comparison of wild type versus mutant BCL 2 , BCL 10 ( L ) indicates these antiapoptotics sequester BH 3 domain only molecules in stable mitochondrial complexes , preventing the activation of BAX , BAK . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In conclusion , by inducing apoptosis , by enhancing apoptosis induced by fludarabine , by suppressing Bcl 2 , Bcl 10 and by inducing Bax expression , PDE 4 inhibitors may add a new therapeutic option for patients with B CLL . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Antiapoptotic proteins , Bcl 2 and Mcl 1 , were not expressed in the giant cells , and Bcl 10 was infrequently expressed in these cells ( 11 % + / 4 % ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 10 ( L ) is an anti apoptotic factor of the Bcl 2 family , which is overexpressed in pancreatic cancer and its presence correlates with shorter patient survival . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Previous studies have demonstrated that KS tumor cells predominantly express the prosurvival protein Bcl 10 ( L ) compared with Bcl 2 . ^^^ Overexpression of Bcl 10 ( L ) , but not Bcl 2 , in SLK cells attenuated apoptosis induced by adenovirus Bcl 10 ( S ) . ^^^ Immunoprecipitation experiments revealed that adenoviral Bcl 10 ( S ) associated with Bcl 10 ( L ) , but not with Bcl 2 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The Brn 3a transcription factor stimulates the expression of the anti apoptotic Bcl 2 and Bcl 10 proteins and protects neuronal cells from apoptosis . ^^^ Hence , Brn 3a mediated activation of two distinct Bcl 10 promoters and of the Bcl 2 promoter is blocked by p 53 whereas this is not observed for Brn 3a activated promoters derived from genes not involved in inhibiting apoptosis . p 53 therefore appears to specifically target the activation by Brn 3a of promoters derived from genes with an anti apoptotic effect and this may be involved in the pro apoptotic activity of p53 . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bad is a pro apoptotic member of the Bcl 2 family of proteins that is thought to exert a death promoting effect by heterodimerization with Bcl 10 ( L ) , nullifying its anti apoptotic activity . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The prognostic significance of apoptosis associated proteins BCL 2 , BAX and BCL 10 in clinical nephroblastoma . ^^^ Various apoptosis associated regulatory proteins , such as Bcl 2 , Bax and Bcl 10 , may contribute to the rate of apoptosis in neoplasia . ^^^ Generally , Bcl 2 , Bax and for Bcl 10 ( S / L ) were expressed in the blastemal and epithelial components of Wilms ' tumour . ^^^ Immunoreactive blastema cells were found in 53 % , 41 % and 38 % of tumours for Bcl 2 , Bax and for Bcl 10 ( S / L ) , respectively . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Detection and evaluation of bcl 10 and bcl 2 gene expression in blasts from patients with acute leukemia ] . ^^^ OBJECTIVE : To investigate the expression of bcl 10 and bcl 2 genes in bone marrow cells of acute leukemia and their effects on response to chemotherapy . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Recently , we have found that a recombinant adenovirus vector that contains a bcl 10 , minigene ( a dominant negative inhibitor of the bcl 2 family ) , called the bcl 10 ( s ) adenovirus , is lethal to cancer cells derived from epithelial tissues , but not to normal human hematopoietic cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The three dimensional ( 3D ) structure of Bcl 2 has been modeled on the basis of a high resolution NMR solution structure of Bcl 10 ( L ) , which shares a high sequence homology with Bcl 2 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The expression of antiapoptotic proteins Bcl 2 , Bcl 10 ( L ) , and Mcl 1 in benign , dysplastic , and malignant biliary epithelium . ^^^ The antiapoptotic members of the Bcl 2 protein family ( Bcl 2 , Bcl 10 ( L ) , and Mcl 1 ) are important inhibitors of apoptosis , but have not been investigated extensively in cholangiocarcinoma . ^^^ METHODS : The expression of Bcl 2 , Bcl 10 ( L ) , and Mcl 1 was investigated in normal biliary epithelium ( 17 ) , biliary dysplasia ( three ) , and invasive cholangiocarcinoma ( 51 ) , in addition to three human cholangiocarcinoma cell lines , by immunohistochemistry and immunofluorescence . ^^^ CONCLUSION : These findings indicate that Mcl 1 and Bcl 10 ( L ) , but not Bcl 2 , are involved in the survival of normal and neoplastic cells in the biliary tree . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Aloe emodin induced apoptosis of CH 27 cells involved modulation of the expression of Bcl 2 family proteins , such as BclX ( L ) , Bag 1 , and Bak , and was associated with the translocation of Bak and Bax from cytosolic to particulate fractions . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
RT PCR analysis indicated that bcl 2 and bcl 10 ( L ) mRNA expression was higher in CSF eosinophils compared with peritoneal eosinophils and this expression in the latter cells was upregulated after culture with mouse recombinant IL 5 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In comparison , strong expression of Bax , Bak and p 21 ( waf1 / cip1 ) and suppressed expression of Bcl 2 , Bcl 10 ( L ) and COX 2 were observed in the Mn SOD antisense group and the expression pattern of these proteins was the inverse in the empty vector group . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NS 398 treatment inhibited proliferation and induced apoptosis of HTLV 1 infected T cell lines and downregulated Bcl 2 and Bcl 10 ( L ) mRNA expression , followed by chromosomal DNA fragmentation . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
EGCG also caused a decrease in the Bcl 2 and Bcl 10 ( L ) proteins , an increase in the Bax protein , and activation of caspase 9 , suggesting that EGCG induces apoptosis via a mitochondrial pathway . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
This effect was preceded by a marked down regulation of two antiapoptotic proteins , Bcl 2 and Bax omega ( respectively reduced by 60 % and 80 % after 3 d ) , whereas no changes occurred in the expression of Bcl 10 ( L ) and the proapoptotic protein Bax alpha . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
CpG DNA up regulated cellular inhibitor of apoptosis proteins ( cIAPs ) as well as Bcl 2 and Bcl 10 ( L ) , but down regulated active caspase 3 . ^^^ Moreover , while the expression of Bcl 2 and Bcl 10 ( L ) depends on both PI3K and p 38 mitogen activated protein kinase , the up regulation of cIAPs and the down regulation of active caspase 3 by CpG DNA require PI3K activation , suggesting PI3K dependent up regulation of cIAPs in the antiapoptotic activity of CpG DNA in DCs . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Exogenous expression of DR 6 , a recently identified member of the TNF receptor family , induced apoptosis in untransformed or tumor derived cells and the apoptotic function of DR 6 was inhibited by co expression of Bcl 2 , Bcl 10 ( L ) or the inhibitor of apoptosis ( IAP ) family member , survivin . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Targeted gene disruptions of members of the bcl 2 and caspase gene families have demonstrated particularly significant roles for bcl 10 , bax , caspase 9 and caspase 3 in mammalian brain development . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Interestingly , both of the two resistant cell lines showed elevated levels of Bcl 10 ( L ) , almost double that of sensitive line ( MIL 5 ) , whereas either Bcl 2 or Bax alpha level did not correlate with the CBDCA resistance . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 and Bcl 10 ( L ) have no effect on TRAIL induced apoptosis in lymphoid cells , whereas these genes block or delay apoptosis in nonlymphoid cancer cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Synergistic potentiation of STI 571 mediated lethality by PD 184352 was associated with multiple perturbations in signaling and apoptotic regulatory pathways , including caspase dependent down regulation of Bcr Abl and Bcl 2 ; caspase independent down regulation of Bcl 10 ( L ) and Mcl 1 ; activation of JNK , p 38 MAPK , and p 34 ( cdc 2 ) ; and diminished phosphorylation of Stat 5 and CREB . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Elevated interleukin 6 during ethanol consumption acts as a potential endogenous protective cytokine against ethanol induced apoptosis in the liver : involvement of induction of Bcl 2 and Bcl 10 ( L ) proteins . ^^^ Expression of both anti apoptotic ( such as Bcl 2 and Bcl 10 ( L ) ) and proapoptotic ( such as Bax ) proteins is markedly elevated in the liver of human ALD and chronically ethanol fed IL 6 ( + / + ) mice . ^^^ On the contrary , induction of Bcl 2 and Bcl 10 ( L ) is not observed in the liver of chronically ethanol fed IL 6 ( / ) mice , whereas expression of Bax protein remains elevated . ^^^ Injection of IL 6 markedly induces expression of Bcl 2 and Bcl 10 ( L ) but not Bax in the liver . ^^^ These findings suggest that elevated serum IL 6 levels in ALD may overcome the inhibitory effect of ethanol on IL 6 mediated anti apoptotic signals and prevent alcohol induced hepatic apoptosis by induction of Bcl 2 and Bcl 10 ( L ) . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Over the past 7 years , many scientists have analyzed different proapoptotic genes such as Fas , Fas ligand , Bcl 10 , caspases as well as antiapoptosis pathways including defects in Fas and Fas ligand , Bcl 2 and caspase inhibitors . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Mitochondrial membrane potential as well as the protein levels of Bcl 2 and Bcl 10 ( L ) decreased 15 60 min and 1 3 h after the exposure to NaCN ( 1mM , 1h ) , respectively . ^^^ Preconditioning prevented NaCN induced decrease in the mitochondrial membrane potential as well as in the protein levels of Bcl 2 and Bcl 10 ( L ) suggesting that preconditioning induced neuroprotection is mediated by preserving mitochondrial function . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
As biomarkers , expression of Bcl 2 , Bax , Bcl 10 , and the accumulation of P 53 protein were also studied immunohistochemically . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Examination of several Bcl 2 family members revealed a selective regulation by each media : CM IL1beta up regulated Bcl 10 ( L ) , while CM IL 8 down regulated Bak expression . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The ratios of the apoptosis regulating proteins Bcl 2 to Bax and Bcl 10 ( L ) to Bax were higher in cells overexpressing wild type , but not NLS mutated , PTHrP compared with control cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The prevention of the staurosporine induced apoptosis by Bcl 10 ( L ) , but not by Bcl 2 or caspase inhibitors , allows the extensive differentiation of human neuroblastoma cells . ^^^ Over expression of Bcl 10 ( L ) was far more effective than Bcl 2 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 and Bcl 10 ( L ) are reported to inhibit CD 95 mediated apoptosis in `` type 2 ' ' but not in `` type 1 ' ' cells . ^^^ However , in contrast to control cells , those overexpressing either Bcl 2 or Bcl 10 ( L ) displayed a distinctive pattern of caspase 3 processing . ^^^ Importantly , Bcl 2 and Bcl 10 ( L ) inhibited the release of both cytochrome c and Smac from mitochondria . ^^^ Thus , mitochondria and associated Bcl 2 and Bcl 10 ( L ) proteins may play a functional role in death receptor induced apoptosis by modulating the release of Smac . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In a immunohistochemical study , stainings for 8 hydroxy deoxyguanosine ( 8 OH dG ) , 4 hydroxy nonenal ( 4 HNE ) , Mn SOD , Bcl 2 , cytochrome c , DNase 1 and Bcl 10 L showed a pronounced granular distribution in the cytochrome c oxidase ( COX ) negative ragged red fibers ( RRFs ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Cell rescue relied on de novo protein synthesis , and the anti apoptotic proteins Bcl 10 ( L ) and Bcl 2 were up regulated in a MEK dependent fashion within 4 h of FGF 2 treatment . ^^^ Indeed , actinomycin D failed to prevent up regulation of Bcl 10 ( L ) and Bcl 2 , and FGF 2 did not increase the mRNA levels or the stability of these proteins . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
This effect was not apparently mediated through downregulation of the PK hBcl 2 transgene or via delocalization of the Bcl 2 protein , and a direct interaction of HBx with Bcl 2 , Bcl 10 ( L ) or Bax could not be evidenced in yeast two hybrid assays . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 overexpression was associated with inhibition of caspase 3 activation after reperfusion and increased baseline levels of cytoplasmic cytochrome c , caspase 3 , and a reduction of Bcl 10 ( L ) production . ^^^ Extensive overproduction of Bcl 2 is associated with a compensatory increase of baseline levels of cytoplasmic cytochrome c and caspase 3 , and a deletion of Bcl 10 ( L ) . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The involvement of the mitochondria pathway was studied by monitoring cytochrome c release and using H 460 cells stable in overexpressing Bcl 2 or Bcl 10 ( L ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Dynamics of expression of apoptosis regulatory proteins Bid , Bcl 2 , Bcl 10 , Bax and Bak during development of murine nervous system . ^^^ We have used immunohistochemistry and immunoblotting to examine the expression of Bid and four other Bcl 2 family proteins ( Bcl 2 , Bcl 10 , Bax and Bak ) in the developing and adult murine central nervous system ( CNS ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The aim of our study was to determine whether mRNA levels of Mdm 2 , Bcl 2 , Bcl 10 ( L ) , Bad , and Bax are independent prognostic parameters for outcome . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The expression of pro and anti apoptotic proteins p 53 , p 21 , MDM 2 , BCL 2 , BCL 10 ( L ) , BCL 10 ( S ) , and BAX , and caspase 3 activity was determined in circulating blasts collected from the peripheral blood of children with leukemia prior to , and at serial time points following chemotherapy . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Expression of Akt did not alter the levels of Bax , Bcl 2 , Bcl 10 ( L ) , or phosphorylated JNK under the conditions used , suggesting that there were alternative mechanisms for Akt in the suppression of Bax translocation . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Expression of apoptosis related genes such as Bax , Bcl 10 ( L ) , Bcl 2 or caspase 8 were reduced by p27Kip1 transduction compared with that of beta actin , whereas p27Kip1 transduction did not affect the expression level of Fas or the Fas ligand . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
OBJECTIVE : To determine the role of apoptosis related proteins ( Myc , Bax , Bcl 2 , and Bcl 10 ( L ) ) in muscular damage in obstructed rat ureters . ^^^ The expressions of Bcl 2 and Bcl 10 ( L ) in the smooth muscle layer were only detected 21 and 28 days after ligation . ^^^ The numbers of apoptotic cells in the smooth muscle layer correlated significantly with the expressions of Myc and Bax ( r = 0 . 7360 and 0 . 7432 , respectively ; both P < 0 . 005 ) , and with the expression index of Bax / Bcl 2 and Bax / Bcl 10 ( L ) ( r = 0 . 8909 and 0 . 8592 , respectively ; both P < 0 . 001 ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Our findings suggest that , although BCL 2 and BCL 6 are most often implicated in DLBCL , the possibility of the disruptions of BCL 3 , BCL 8 , BCL 9 , and BCL 10 as a `` primary event ' ' in DLBCL can not be ruled out . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The expression of Bcl 2 family proteins ( Bcl 2 , Bcl 10 , Bax , Bak and Bim ) in human lymphocytes . ^^^ We investigated the expression of Bcl 2 , Bcl 10 , Bax , Bak and Bim in human lymphocytes using flow cytometry . ^^^ Among peripheral blood lymphocytes ( PBL ) , CD 8 ( + ) T cells expressed an approximately ten fold higher level of Bcl 10 than CD 4 ( + ) T cells while both subsets expressed similar levels of Bcl 2 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Expression of Bcl 10 , Bcl 2 , Bax , and Bak in endarterectomy and atherectomy specimens . ^^^ The aim of this study was to determine the expression of Bcl 2 , Bcl 10 , Bax , and Bak in relation to apoptosis in advanced atherosclerotic lesions . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
It inhibits hypoxia induced caspase 3 activation , mitochondrial cytochrome c release , downregulation of Bcl 2 and Bcl 10 ( L ) , upregulation of hypoxia inducible factor ( HIF ) 1 alpha , and loss of mitochondrial transmembrane potential in human leukemia HL 60 cell line . ^^^ Thus 2 deoxy D ribose modulated suppression of HIF 1 alpha expression could prevent the hypoxia induced decrease of the anti apoptotic Bcl 2 and Bcl 10 ( L ) on the mitochondria . 2 Deoxy L ribose and its analogs may enhance apoptosis and suppress the growth of tumors by competitively inhibiting the activities of 2 deoxy d ribose and thus these analogs show promise for anti tumor therapy . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Expression of Bcl 2 , Bcl 10 , Mcl 1 , Bax and Bak in human uterine leiomyomas and myometrium during the menstrual cycle and after menopause . ^^^ To investigate the expression of Bcl 2 , Bcl 10 , Mcl 1 , Bax and Bak proteins in human uterine leiomyomas and homologous myometrium during the menstrual cycle and after menopause . ^^^ The expression of Bcl 2 , Bcl 10 , Mcl 1 , Bax and Bak in leiomyomas ( n=24 ) and myometrial samples ( n=22 ) from women with leiomyomas was measured by immunohistochemistry and Western blot . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
METHODS : Bcl 2 , Bax , Bcl 10 , Fas ( CD 95 ) and tumor necrosis factor ( TNF ) receptor expression was determined by flow cytometry in control and mitomycin C treated Tenon fibroblasts . ^^^ RESULTS : Tenon fibroblasts constitutively express Bcl 2 , Bax , and Bcl 10 in culture . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We found that Tax mediated apoptosis in response to UV irradiation was inhibited by Bcl 2 and Bcl 10 ( L ) overexpression and by treatment with the caspase inhibitor z VAd FMK . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Upon induction of apoptosis , Bax formed homo oligomers in the mitochondrial fraction with no evidence for cross linking to Bcl 2 or Bcl 10 ( L ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We demonstrated previously that overexpression of BCL 2 or BCL 10 ( L ) enhanced the frequency of 10 ray induced TK 1 mutations , including loss of heterozygosity events presumed to arise by mitotic recombination . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
BL cells that had drifted to a lymphoblastic group 3 phenotype were relatively resistant to these actions of serotonin , and the forced ectopic expression of either bcl 2 or bcl 10 ( L ) provided substantial protection from 5 HT induced apoptosis . 5 HT receptor antagonists ( SDZ 205 557 , granisetron , methysergide ) failed to inhibit serotonin induced apoptosis , whereas the selective serotonin reuptake inhibitors ( SSRI ) fluoxetine ( Prozac ) , paroxetine ( Paxil ) , and citalopram ( Celexa ) substantially blocked the monoamine actions . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The expression of thymidylate synthase ( TS ) , p 53 , retinoblastoma protein ( Rb ) , Fas receptor , Fas ligand , bcl 2 , mcl 1 , bax , and bcl 10 was measured using immunohistochemistry . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Since no consistent differences in Bcl 2 , Bcl 10 ( L ) or Bax expression were seen in the STS and radiation resistant neuroblastomas , it suggests that a unique mitochondrial signaling factor ( s ) is responsible for the defect in cytochrome c release in this sub group of tumors . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Comparison of the KSHV Bcl 2 structure to that of Bcl 2 and Bcl 10 ( L ) shows that although the overall fold is the same , there are key differences in the lengths of the helices and loops . ^^^ Binding studies on peptides derived from the Bcl 2 homology region 3 of proapoptotic family members indicate that the specificity of the viral protein is very different from what was previously observed for Bcl 10 ( L ) and Bcl 2 , suggesting that the viral protein has evolved to have a different mechanism of action than the host proteins . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The other ovary was used for immunohistochemical analysis of selected members of the B cell lymphoma / leukemia 2 family of protooncogenes ( Bax , Bcl 2 , Bcl 10 ) , proliferating cell nuclear antigen ( PCNA ) , and cyclin dependent kinase 2 ( Cdk 2 ) . ^^^ Further , the results indicate that Smad 3 may regulate the expression of Bax and Bcl 2 , but not Bcl 10 , Cdk 2 , and PCNA . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We also determined the expression of the anti apoptotic proteins bcl 2 and bcl 10 ( L ) under these culture conditions . ^^^ Both colon cell lines had increased expression of anti apoptotic proteins bcl 2 and bcl 10 ( L ) when cultured on the various ECMs and with the drugs , but there was no correlation between a protective ECM effect and expression of the anti apoptotic proteins . ^^^ Stromal derived ECM may protect colon cancer cells from etoposide and camptothecin induced apotosis , through a mechanism that is not bcl 2 or bcl 10 ( L ) dependant . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Resistance of colon cancer cells to long term 5 fluorouracil exposure is correlated to the relative level of Bcl 2 and Bcl 10 ( L ) in addition to Bax and p 53 status . ^^^ In addition , we found that high levels of anti apoptotic Bcl 2 and Bcl 10 ( L ) proteins combined with a low level of Bax were correlated to high 5 FU resistance of wild type p 53 cell lines . ^^^ In conclusion , the relative levels of Bcl 2 , Bcl 10 ( L ) and Bax may altogether contribute to determine the resistance of a majority of colon tumor cells to long term 5 FU treatment , whatever their p 53 status . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Levels of bcl 2 , bcl 10 , bax , p 53 and p 21 were determined by Western blotting , and celi cycle analysis was determined by flow cytometry . ^^^ Neither IL 1 nor ceramide induced apoptosis in EEC , but they increased bcl 2 levels and decreased bax and p 21 levels without affecting bcl 10 and p 53 levels . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Indeed , DC activation effectively inhibited DC apoptosis , which was predominantly accompanied by the upregulation of Bcl 10 ( L ) and to a lesser extent Bcl 2 , while Bax and FLICE inhibitory protein ( FLIP ) remained unchanged . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We demonstrate that ( 1 ) forced MTA 1 expression enhances migration and invasion of immortalized keratinocytes ; ( 2 ) MTA 1 expression is necessary but not sufficient for cell survival in the anchorage independent state ; ( 3 ) MTA 1 contributes to expression of the anti apoptotic Bcl 2 family member Bcl 10 ( L ) ; ( 4 ) MTA 1 expression in immortalized keratinocytes depends , in part , on activation of the epidermal growth factor receptor ( EGFR ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Cell permeable BH 3 peptides overcome the cytoprotective effect of Bcl 2 and Bcl 10 ( L ) . ^^^ BaxBH3Ant and Bcl2BH3Ant caused a mitochondrial membrane permeabilization ( MMP ) and apoptosis , via a mechanism that was not inhibited by overexpressed Bcl 2 or Bcl 10 ( L ) , yet partially inhibited by cyclosporin A ( CsA ) , an inhibitor of the mitochondrial permeability transition pore . ^^^ However , Bcl 2 or Bcl 10 ( L ) failed to inhibit MMP induced by BaxBH 3 and Bc2BH3 in vitro , while they efficiently suppressed the induction of MMP by the Vpr protein ( from human immunodeficiency virus 1 ) , a ligand of the adenine nucleotide translocator ( ANT ) . ^^^ In conclusion , BaxBH 3 and Bcl2BH3 induce MMP and apoptosis through a mechanism which overcomes cytoprotection by Bcl 2 and Bcl 10 ( L ) . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bad , Bax , Bcl 10 ( S ) ) were reduced 2 4 fold in the resistant cell line , whereas the anti apoptotic proteins Bcl 2 and Bcl 10 ( L ) were expressed at similar levels in both cell lines . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Cellular commitment to apoptosis is partly regulated by the Bcl 2 family proteins , which includes the death antagonists Bcl 2 and Bcl 10 ( L ) , and death agonists Bax and Bad . ^^^ Cellular expression of Bcl 2 , Bcl 10 ( L ) , Bax or Bad in MS patients was independent of the expression of other apoptotic regulatory molecules , such as Fas receptor protein or FLIP . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The overexpressed genes included c Jun N terminal kinases 1 , 2 and 3 , bcl 10 , bcl 2 associated death promoter and bcl 2 related ovarian killer protein , caspases 1 , 3 and 6 , DNase 1 precursor , DNA topoisomerases 1 and 2 alpha , and poly ( ADP ribose ) polymerase . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Hypothermia also increased expression for the anti apoptotic Bcl 2 homologue Bcl 10 relative to 1 but decreased expression for the proapoptotic Bcl 2 homologue bak . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In vitro both ubiquitous calpains cleaved recombinant Bcl 2 , Bid , and Bcl 10 ( L ) at single sites truncating their N terminal regions . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Since the Bcl 2 family is critically involved in the regulation of apoptosis , we investigated the protein expression of Bcl 2 , Bcl 10 ( L ) , and Bax in peripheral blood mononuclear cells ( PBMC ) of 23 MS patients and 29 control subjects . ^^^ In contrast to Bcl 10 ( L ) , no differences were found in the protein expression of Bcl 2 and Bax between patients and controls . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In agreement with this role of ROS in apoptosis signaling , inhibition of apoptosis by anti apoptotic Bcl 2 and Bcl 10 ( L ) is associated with a protection against ROS and / or a shift of the cellular redox potential to a more reduced state . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The function of the second domain is still unknown . vMIA does not share any significant amino acid sequence homology with Bcl 2 , and , unlike Bcl 2 or Bcl 10 ( L ) , it does not bind BAX or VDAC . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
By using a ribonuclease protection assay , the ratios of both pro and antiapoptotic mRNA ( bcl 10 , bcl 2 , bax , caspase 2 , and caspase 3 ) to the housekeeping glyceraldehyde phosphate dehydrogenase ( GAPDH ) gene were determined . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The results presented here indicated that the cell lines responsive to 2 ME could undergo apoptosis either by G 2 M arrest ( PANC 1 ) with Bcl 10 ( L ) phosphorylation or by the accumulation of tetraploid cells in G 1 S region ( MIA PaCa 2 ) without Bcl 2 / Bcl 10 ( L ) phosphorylation . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The anti apoptotic effect of glucocorticoids is exerted by modulation of several survival genes such as Bcl 2 , Bcl 10 ( L ) and NFkappaB , in a cell type specific manner . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Our results show that mRNA expression levels of Bcl 2 , hsp 70 , c myc , Bcl 10 ( l ) , caspase 3 , and caspase 6 remain essentially constant when apoptosis is stimulated by estrogen withdrawal . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The Mtb induced apoptosis was associated with a speedy and transient increase in expression of Bax protein , a proapoptotic member of the Bcl 2 family , and a more prominent reduction in expression of the antiapoptotic protein Bcl 10 ( L ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Rasagiline increased the levels of bcl 2 and bcl 10 ( l ) mRNA at 100 10 nM and 100 10 pM , but not the level of pro apoptotic bax mRNA . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In addition , gene expression analysis revealed that EGCG prevented both the 6 OHDA induced expression of several mRNAs , such as Bax , Bad , and Mdm 2 , and the decrease in Bcl 2 , Bcl w , and Bcl 10 ( L ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Our data demonstrated that Gyp induced apoptotic cell death was accompanied by up regulation of Bax , Bak and Bcl 10 ( L ) , and down regulation of Bcl 2 and Bad , while it had no effect on the level of Bag 1 protein . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
After cyanide ( 100 500 microm ) treatment for 24 h , two pro apoptotic Bcl 2 proteins , Bcl 10 ( S ) and Bax were up regulated as shown by western blot and RT PCR analysis . ^^^ The expression levels of two antiapoptotic Bcl 2 proteins , Bcl 2 and Bcl 10 ( L ) , remained unchanged after cyanide treatment , whereas the mRNA levels of Bcl 10 ( S ) and Bax began to increase within 2 h and their protein levels increased 6 h after treatment . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Immunoblotting for Bcl 2 family members revealed no significant changes in the expression levels of Bcl 2 , Bcl 10 ( L ) , Bax or Bak following gene or ' chemogene ' therapy with E2F 1 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Four molecules of the Bd 2 family ( BID , Bcl 2 , Bax , Bcl 10 ( L ) ) have been reported to be deaved during apoptosis , as has a cellular inhibitor of apoptosis ( XIAP ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Blood and liver were analyzed for plasma aminotransferase activity , liver histology , liver apoptotic nuclei , mRNA of several cytokines ( tumor necrosis factor [ TNF ] alpha , interleukin [ IL ] 1beta , IL 6 , and IL 10 ) , apoptotic ligands ( TRAIL ) , cytokine receptors ( TNFRp 55 ) , pro and antiapoptotic regulators / adaptors ( Fas receptor , FasL , FADD , TRADD , RIP , Bak , Bax , Bcl 10 , Bcl 2 and Bcl w ) , and caspase 8 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Furthermore , increased DNA fragmentation and numbers of early and late apoptotic cells were seen , but caspases 3 and 8 activities and expression of Fas , Bcl 2 , Bcl 10 and p 53 remained unchanged . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Antisense strategy shows that Mcl 1 rather than Bcl 2 or Bcl 10 ( L ) is an essential survival protein of human myeloma cells . ^^^ The present study used an antisense strategy to elucidate the respective roles of Bcl 2 , Bcl 10 ( L ) , and Mcl 1 proteins in myeloma cell survival . ^^^ Each antisense oligonucleotide ( ASO ; Bcl 2 , Bcl 10 ( L ) , or Mcl 1 ASO ) introduced into human myeloma cell lines by electroporation induced a marked reduction in the level of the corresponding protein . ^^^ Mcl 1 ASO triggers an important decrease of viability in all myeloma cell lines tested and in 2 primary myeloma cells , whereas neither Bcl 2 nor Bcl 10 ( L ) ASO affected the viability of myeloma cells . ^^^ Finally , although Bcl 2 ASO treatment alone has no effect , it can sensitize myeloma cell lines to dexamethasone ( Dex ) , whereas Bcl 10 ( L ) ASO in combination with Dex still had no effect . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
MCF 7 cells were cultured with either 1 nM melatonin , 100 nM D 3 or its diluent to determine their effects on cell proliferation , cell viability , cell cycle phase distribution , population of apoptotic cells , and expression of p 53 , p21WAF1 , bcl 2 , bcl 10 ( L ) and bax proteins . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We observed no detectable changes in the steady state levels of Bcl 10 ( L ) , Bax , and Bid , although TNF suppresses Bcl 2 expression . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
TUNEL staining detected apoptotic T cells at low frequency corresponding to an increased expression of the anti apoptotic molecules Bcl 2 and Bcl 10 ( L ) and a reduced expression of the pro apoptotic molecules Bad , Bax , and Fas ligand in CD 4 and CD 8 T cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In the present study , we tried to clarify the potentially protective role of Bcl 10 ( L ) , an anti apoptotic member of the Bcl 2 family of proteins , in Parkinson ' s disease ( PD ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Nevertheless , overexpression of the anti apoptotic Bcl 2 homolog Bcl 10 ( L ) markedly inhibited p 14 ( ARF ) induced apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Intracisternal administration of aluminum into rabbit brain induces cytochrome c release , decreases levels of the anti apoptotic proteins Bcl 2 and Bcl 10 ( L ) , increases levels of the pro apoptotic Bax , activates caspase 3 , and causes DNA fragmentation as measured by the TUNEL assay . ^^^ Pretreatment for 14 days with 7 mm of lithium carbonate in drinking water prevents aluminum induced translocation of cytochrome c , and up regulates Bcl 2 and Bcl 10 ( L , ) down regulates Bax , abolishes caspase 3 activity and reduces DNA damage . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Further studies demonstrated that the expression of Bcl 2 and Bcl 10 ( L ) decreased in both mRNA and protein levels , whereas p 53 and Bax increased after anti NS 1 treatment . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Moreover , NCTD treatment also increased the phosphorylation of Bcl 2 and Bcl 10 ( L ) but did not affect the expression of Bax or Bad . ^^^ Furthermore , the increase of p 21 ( Cip1 / Waf1 ) , phosphorylation of Bcl 2 and Bcl 10 ( L ) , activation of caspase 9 and caspase 3 may be the molecular mechanism through which NCTD induces apoptosis . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Detailed tissue expression of bcl 2 , bax , bak and bcl 10 in the normal human pancreas and in chronic pancreatitis , ampullary and pancreatic ductal adenocarcinomas . ^^^ METHOD : Expression of bcl 2 , bax , bcl 10 , bak and p 53 was determined in formalin fixed paraffin wax embedded archival specimens of normal pancreatic tissue ( n = 7 ) , chronic pancreatitis ( n = 7 ) , pancreatic ductal adenocarcinoma ( n = 23 ) and ampullary cancer ( n = 7 ) by immunohistochemistry using specific antibodies . ^^^ RESULTS : In normal pancreas and chronic pancreatitis tissues , bcl 2 , bax and bcl 10 were predominantly expressed in ductal epithelial cells while p 53 was not detected . ^^^ In pancreatic ductal adenocarcinoma and ampullary cancer , bcl 2 was not detected compared with expression seen in normal acini ( p < 0 . 01 ) , minor ( p < 0 . 001 ) and major ducts ( p < 0 . 01 ) , bax expression was reduced with respect to minor ducts ( p < 0 . 01 ) but no different from normal acini or major ducts . bak and bcl 10 were more strongly expressed in malignant epithelia compared with acini and major ducts but reduced when compared with minor ducts ( p < 0 . 01 ) . ^^^ CONCLUSION : Pancreatic and ampullary cancer are associated with absent bcl 2 expression . bax , bak and bcl 10 expression was reduced compared with normal minor ducts whilst bak and bcl 10 expression was increased when compared with major ducts . bcl 10 expression correlates with survival following resection and may represent a potential prognosis marker . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
RESULTS : Exogenous expression of Bcl 10 ( L ) or Bcl 2 in primary murine erythroblasts or clonal erythroblast lines derived from p 53 ( / ) mice allowed these cells to undergo terminal erythroid maturation , in the complete absence of cytokines . ^^^ Epo independent differentiation in these Bcl 10 ( L ) or Bcl 2 expressing , primary erythroblasts was thus triggered by removal of the renewal factors SCF and Dex . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The phosphorylation state of antiapoptotic ( Bcl 2 , Bcl 10 ( L ) ) and proapoptotic ( BAD , Bid , Bik ) Bcl 2 proteins regulates their cellular activity and , therefore , cell survival and cell death . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Peptides derived from BH 3 domains of Bcl 2 family members : a comparative analysis of inhibition of Bcl 2 , Bcl 10 ( L ) and Bax oligomerization , induction of cytochrome c release , and activation of cell death . ^^^ In vitro interaction assays were used to compare the abilities of the different peptides to inhibit Bax / Bcl 2 and Bax / Bcl 10 ( L ) heterodimerization , as well as Bcl 2 and Bax homodimerization . ^^^ Bax BH 3 peptide ( 20 amino acids ) potently inhibited both Bax / Bcl 2 and Bax / Bcl 10 ( L ) interactions , exhibiting IC ( 50 ) values of 15 and 9 . 5 microM , respectively . ^^^ The Bad BH 3 peptide ( 21 amino acids ) was slightly more potent than Bax BH 3 at inhibiting Bax / Bcl 10 ( L ) but failed to disrupt Bax / Bcl 2 . ^^^ Bcl 2 BH 3 peptide ( 20 amino acids ) was inactive toward Bax / Bcl 2 and had only a weak inhibitory effect on Bax / Bcl 10 ( L ) heterodimerization . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
By contrast , Bcl 2 , Bcl 10 and Mcl 1 proteins were highest in rapidly adhering keratinocytes and nearly absent in slowly adhering cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
MAIN OUTCOME MEASURE ( S ) : Proliferation was determined by using a morphometric growth index , apoptosis by using morphologic analysis and flow cytometry , and antiapoptotic proteins bcl 2 and bclx ( L ) by using Western blot assay . ^^^ These proapoptotic effects were at least partially mediated through decreased expression of the antiapoptotic proteins bcl 2 and bclx ( L ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The bax / bcl 2 ratio is predictive of chemotherapy sensitivity , whereas bcl 10 ( L ) and mcl 1 mRNA levels following repeated exposure to 5 FU or gemcitabine are associated with resistance to these drugs . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The anti apoptotic genes Bcl 10 ( L ) and Bcl 2 are over expressed and contribute to chemoresistance of non proliferating leukaemic CD34+ cells . ^^^ As the anti apoptotic genes Bcl 2 and Bcl 10 ( L ) have been implicated in cell cycle regulation , we investigated the expression of these genes in non proliferating ( Q ) and proliferating ( P ) AML and normal CD34+ progenitor cells . ^^^ Using reverse transcription polymerase chain reaction , Bcl 10 ( L ) and Bcl 2 were overexpressed in Q versus P AML cells , whereas no difference in Bcl XS and Bax expression was found . ^^^ Furthermore , the Bcl 10 ( L ) / X ( S ) but not the Bcl 2 / Bax ratio was higher in Q AML compared with normal CD34+ Q cells ( P = 0 . 001 ) . ^^^ Treatment with all trans retinoic acid ( ATRA ) reduced Bcl 2 and Bcl 10 ( L ) expression in the leukaemic Q cells , and enhanced their chemosensitivity to cytosine arabinoside ( ara C ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Department of Veterans Affairs Cooperative Study Program ( VA CSP 268 ) were evaluated for the expression of Bcl 2 , Bcl 10 ( L ) , and Bax protein expression . ^^^ CONCLUSIONS : The findings indicate that laryngeal cancer cells typically produce high levels of only one of the apoptosis protective proteins , Bcl 2 or Bcl 10 ( L ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In both classes , after counting the incidence , adenomas were examined for vascularity , expression of COX 2 and VEGF protein , labeling proliferating cell nuclear antigen ( PCNA ) and apoptosis with the TdT mediated dUTP nick end labeling method , including expression of Bcl 2 and Bcl 10 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Protein levels of B cell lymphoma protein 2 ( BCL 2 ) , BCL 10 ( L / S ) , heat shock protein 70 / 90 , and BCL 2 associated death protein remained unaltered . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Investigation of bax , bcl 2 , bcl 10 and p 53 gene polymorphisms in multiple sclerosis . ^^^ To analyze genetic differences in the apoptosis regulating factors bcl 2 , bax , bcl 10 and p 53 we investigated polymorphisms of these genes in 105 patients with a relapsing remitting disease course and 99 controls by PCR SSCP and direct sequencing . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Fibroblast like synoviocytes from rheumatoid arthritis patients express functional IL 15 receptor complex : endogenous IL 15 in autocrine fashion enhances cell proliferation and expression of Bcl 10 ( L ) and Bcl 2 . ^^^ Next , we investigated the effects of exogenous or endogenous IL 15 on Bcl 2 and Bcl 10 ( L ) expression , FLS proliferation , and apoptosis . ^^^ We found that blocking IL 15 biological activities using this protein substantially reduced endogenous expression of Bcl 2 and Bcl 10 ( L ) , and RA FLS proliferation that was reflected by increased apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Examination of the expression of several apoptosis regulatory proteins revealed that coculture with HK cells or DCs induced up regulation of the antiapoptotic Bcl 2 family protein Mcl 1 in CLL B cells , whereas CD 40 ligation increased expression of Bcl 10 ( L ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
DEX increases the expression of anti apoptotic Bcl 2 and Bcl 10 ( L ) proteins , decreases the expression of pro apoptotic Bax and inhibits Bad translocation thereby preventing the release of cytochrome c , the activation of caspases , and cell death . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
CD 40 ligation and TNF alpha prevented release of cytochrome c and activation of caspase 3 , which could not be explained by effects on the expression of Bcl 2 , Bcl 10 ( L ) or Bax . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
To analyze the mechanisms of the apoptotic activity of Cl F araA , we sought to determine the effects of the drug on the levels of Bcl 2 family proteins ( Bcl 2 , Bcl 10 ( L ) , Mcl 1 , Bax , Bak ) and cell survival signals via Akt . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Three members of the inhibitor of apoptosis protein ( IAP ) family , namely cellular ( c ) IAP 1 , c IAP 2 , and XIAP , and 2 antiapoptotic proteins of the Bcl 2 family , namely Bcl 10 ( L ) and Bfl 1 / A1 , were investigated . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We examine the influence of apoptosis status and the expression of antiapoptotic proteins Bcl 2 and Bcl 10 ( L ) on metastatic progression and response to therapy in an experimental model of breast cancer . ^^^ The overexpression of Bcl 2 or Bcl 10 ( L ) influenced tumorigenicity , 468 transfectants being less tumorigenic than control ( p < 0 . 0001 ) . ^^^ Lung metastasis appeared at day 120 in animals injected with 435 / Bcl 2 or 435 / Bcl 10 ( L ) and they showed higher metastatic activity than control 435 / Neo tumors ( p = 0 . 02 ) . ^^^ In contrast , mice with 468 tumors were followed for 1 year after tumor excision , but they did not develop metastatic foci . 435 / Bcl 2 and 435 / Bcl 10 ( L ) transfectant cells bound less readily to laminin ( ANOVA , p < 0 . 0001 ) , fibronectin ( ANOVA , p < 0 . 0001 ) and collagen type 4 ( ANOVA , p < 0 . 0001 ) than 435 / Neo cells . ^^^ Thus , the overexpression of the Bcl 2 or Bcl 10 ( L ) associated with the loss of apoptosis in breast cancer cells in vivo may account for their metastatic behavior . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Image cytometric bcl 2 : bax and bcl 2 : bcl 10 ratios in invasive breast carcinoma : correlation with prognosis . ^^^ Some of the members , such as bcl 2 and bcl 10 ( L ) , inhibit cell death , whereas others , such as bax and bcl 10 ( S ) , promote cell death . ^^^ We evaluated the ratios of bcl 2 : bax and bcl 2 : bcl 10 expression by image cytometry in invasive breast carcinoma to determine prognostic significance . ^^^ DESIGN : Five micron sections of formalin fixed , paraffin embedded tissue from 88 invasive breast carcinomas were immunostained using steam antigen retrieval , an avidin biotin complex technique with automated stainer and primary antibodies against bcl 2 ( 1 / 160 ; Dako , Carpenteria , CA ) , bax ( 1 / 1 , 500 ; PharMingen , San Diego , CA ) , and bcl 10 ( 1 / 1 , 500 ; PharMingen ) . ^^^ Positive controls were tonsil ( bcl 2 ) and normal breast ( bax and bcl 10 ) tissue samples . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We have investigated whether subsets of indolent B cell non Hodgkin ' s lymphoma ( IB NHL ) differ in the expression of the bcl 2 family members ; 116 cases of IB NHL , composed of chronic lymphocytic leukemia ( CLL , n = 48 ) , follicular lymphoma ( FL , n = 38 ) , marginal zone B cell lymphoma ( MZBCL , n = 15 ) , and mantle cell lymphoma ( MCL , n = 15 ) , were investigated for expression of bcl 2 , bcl 10 , mcl 1 , bax , and bak proteins by immunohistochemistry . ^^^ Expression of bcl 2 and bcl 10 proteins was moderate / high among most IB NHLs . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The anti apoptotic effect of glucocorticoids is exerted by modulation of several survival genes such as Bcl 2 , Bcl 10 ( L ) , and NFkB , in a cell specific manner . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The absence of Stat 5 resulted in aberrant control of Bcl 2 , Bcl 10 ( L ) and cyclin A 2 , with increased apoptosis and delayed cell cycle progression after IL 3 or SCF stimulation . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The concentrations of the pro apoptotic molecule caspase 3 and of plasmin were both increased in transgenic animals whilst the concentrations of 2 prosurvival molecules Bcl 2 and Bcl 10 ( L ) were both decreased . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Adenovirus transduced MO DCs were also more potent stimulators of allogeneic lymphocytes , produced increased amounts of the cytokines tumor necrosis factor alpha and interleukin 12 p 70 , and exhibited increased expression of NF kappaB and antiapoptotic molecules Bcl 10 ( L ) and Bcl 2 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
No correlation was found between apoptosis sensitivity and the expression of TNF receptor 1 or the expression of Bax , Bcl 2 and Bcl 10 ( L ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Enforced expression of anti apoptotic protein Bcl 2 or Bcl 10 ( L ) inhibited TRAIL induced mitochondrial dysfunction and apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Furthermore , while Fas stimulation of resistant control 3D10 cells led to increases in the antiapoptotic proteins cellular inhibitor of apoptosis protein 1 and 10 linked inhibitor of apoptosis protein , Fas induced apoptosis in IkappaBalpha overexpressing cells led to the down modulation of both of these proteins , as well as that of the Bcl 2 family protein , Bcl 10 ( L ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
CD 437 mediated apoptosis was not associated with the modulation of Bcl 2 , Bax , or Mcl 1 levels , but was associated with the cleavage of the antiapoptotic protein Bcl 10 ( L ) to a proapoptotic 18 kD form . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Immunohistochemical analyses of bcl 2 , bax , bcl 10 , and steroid receptors were performed in 22 endometrial carcinomas , 26 endometrial hyperplasias , and 19 cases of normal cyclical endometrium . ^^^ There was increased expression of bax , decreased expression of bcl 2 , and persistence of bcl 10 protein in advanced endometrial carcinomas . ^^^ Our findings show that ovarian hormones have a regulatory role on bcl 2 protein and that there is a correlation between other members of the bcl 2 family ( bcl 10 and bax ) and steroid hormone receptors . ^^^ Bax / bcl 10 may be the major control mechanisms of apoptosis in advanced carcinomas ; other members of the bcl 2 family may also be under hormonal control . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Reduced apoptosis observed after co stimulation in the presence of accessory cells correlated with increased levels of Bcl 10 ( L ) in CD 8 ( + ) T cells , while Bcl 2 expression remained unchanged . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The behaviour of Bcl 2 , Bax and Bcl 10 in Darier ' s disease . ^^^ There is little information on the behaviour of Bcl 2 , Bax and Bcl 10 in DD . ^^^ OBJECTIVES : To investigate the dynamic control and the behaviour of Bax , Bcl 2 and Bcl 10 in DD . ^^^ RESULTS : There was no immunoreactivity for Bcl 2 and Bcl 10 in epidermal keratinocytes in lesional epidermis . ^^^ CONCLUSIONS : The decrease or absence of Bcl 2 and Bcl 10 and the imbalance of Bax in the epithelial cells of affected DD skin is likely to be an important control point determined by the genetic mutation of SERCA 2 , which modifies the programme of the antiapoptotic proteins . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We also detected the expression of Bax , Bak , p 53 , Bcl 2 , Bcl 10 ( L ) , AIF and MRP 1 by Western blots . ^^^ Bcl 2 protein expression was significantly increased in p 50 , p 46 and p 33 transfected cells , while the expression of Bax , Bak , p 53 , Bcl 10 ( L ) and MRP 1 was essentially unchanged . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Hepatocellular carcinoma and markers of apoptosis ( bcl 2 , bax , bcl 10 ) : prognostic significance . ^^^ Patients with tumors expressing promoters of apoptosis ( bax ) versus inhibitors of apoptosis ( bcl 2 , bcl 10 ) may have increased survival . ^^^ Seventy HCC were immunostained for bcl 2 , bax , and bcl 10 . ^^^ Staining frequency for bcl 2 , bax , and bcl 10 was 20 % , 66 % , and 60 % , respectively . ^^^ Patients with no or low bcl 10 tended toward improved survival compared with patients with more bcl 10 in their HCC . bcl 2 expression did not correlate with prognosis . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Impact of coexpression and coamplification of sICAM and antiapoptosis determinants bcl 2 / bcl 10 ( L ) on productivity , cell survival , and mitochondria number in CHO DG 44 grown in suspension and serum free media . ^^^ We have engineered dihydrofolate reductase negative ( dhfr / ) Chinese hamster ovary ( CHO ) DG 44 cells adapted for growth in serum free suspension cultures for simultaneous expression of the common cold therapeutic , the soluble intercellular adhesion molecule 1 ( sICAM ) , and the antiapoptosis determinants bcl 2 or bcl 10 ( L ) . ^^^ Detailed analyses of titer and antiapoptosis characteristics of these production cell lines included an independent ( sICAM ; bcl 2 / bcl 10 ( L ) ) as well as a cocistronic ( sICAM ( bcl 2 / bcl 10 ( L ) ) ) expression set up in which translation initiation of the survival cistron is driven by an internal ribosome entry site ( IRES ) of the encephalomyocarditis virus ( EMCV ) . ^^^ In transient transfections or stable mixed populations and in comparison to isogenic sICAM only control vectors , both bcl 10 ( L ) encoding configurations achieved higher sICAM yields while bcl 2 over expression resulted in decreased product levels . ^^^ Overall , the death protective impact of bcl 2 and bcl 10 ( L ) in engineered CHO DG 44 was not significant under typical batch mode operation , an observation that was confirmed by clonal analysis . bcl 2 and bcl 10 ( L ) displayed their antiapoptosis potential only following dhfr based amplification in sICAM producing CHO DG 44 cell lines . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The present study therefore , examines the expression of active and proactive caspase 3 , and the bax , bcl 2 and bcl 10 members of the bcl 2 family , to characterise the temporal profile of apoptosis in a model of traumatic brain injury in rats that produces significant diffuse axonal injury . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
IL 1beta induced CFb apoptosis was associated with an increase in p 53 and Bax protein expression with no changes in Bcl 2 or Bcl 10 ( L ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
At the cellular level , infection with 10 induced a decrease in the levels of Bcl 10 ( L ) , an anti apoptotic member of the Bcl 2 family . ^^^ The importance of loss of Bcl 10 ( L ) was demonstrated by prevention of 10 mediated apoptosis on expression of Bcl 2 , a functional homologue of Bcl 10 ( L ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Furthermore , the phosphorylation of Bcl 2 and Bcl 10 ( L ) proteins in Taxol treated cells was detected at 8 h . ^^^ These results suggest that , following the phosphorylation of Bcl 2 and Bcl 10 ( L ) proteins , Taxol induced apoptosis is induced through the mitochondria dependent pathway in T 24 cells . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Curcumin also down regulated the expression of NF kappaB regulated gene products , including IkappaBalpha , Bcl 2 , Bcl 10 ( L ) , cyclin D 1 , and interleukin 6 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Although STAT 3 activation is known to induce expression of Bcl 2 family proteins , PEL cell apoptosis was independent of Bcl 2 , Bcl 10 ( L ) , or Mcl 1 protein expression . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Most types of low growth fraction lymphomas are initiated by molecular events resulting in the inhibition of apoptosis , such as translocations affecting BCL 2 , in follicular lymphoma , or BCL 10 and API2 / MLT1 , in mucosa associated lymphoid tissue ( MALT ) lymphomas . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Striking findings were the overexpression of cyclin E , CDK 2 , CDK 6 , STAT 3 , Hdm 2 , Bcl 2 , Bcl 10 ( L ) , survivin , and NF kappaB proteins . ^^^ Survival probability depends on multiple biologic factors , including overexpression of Bcl 2 , p 53 , Bax , Bcl 10 ( L ) , MIB 1 , and apoptotic index . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The resistance of this cell subset to starvation induced programmed cell death , lasting from 48 to 96 hours , is accompanied by a rise of mitochondrial adenosine triphosphate ( ATP ) , a high nicotinamide adenine dinucleotide ( NAD ) / reduced nicotinamide adenine dinucleotide ( NADH ) ratio , and by the up regulation of expression of the antiapoptotic proteins Bcl 2 and Bcl 10 , together with an increase in the cytoplasmic , inactive , form of Bax . ^^^ Interestingly , ligation of the platelet endothelial cell adhesion molecule 1 ( PECAM 1 ) , which drives CD 14 ( + ) CD 34 ( + ) transendothelial migration , leads to an increase in Bcl 2 A 1 and Bcl 10 intracellular content , and to protection from starvation induced apoptosis . ^^^ This event is dependent on the engagement of phosphatidylinositol 3 kinase and activation of Akt / PKB that is known to contribute to Bcl 2 and Bcl 10 induction . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We hypothesized that apoptosis is a downstream event in erectile dysfunction , and pro apoptotic ( Bak and Bax ) and anti apoptotic ( Bcl 2 and Bcl 10 ) factors are involved in the etiology of aging erectile dysfunction . ^^^ Gene expression of pro apoptotic ( Bak and Bax ) and anti apoptotic ( Bcl 2 and Bcl 10 ) factors were then analyzed by reverse transcription polymerase chain reaction . ^^^ The anti apoptotic Bcl 2 and Bcl 10 genes were expressed in 3 , 6 and 12 month old crura , whereas this expression was lost at 18 , 24 and 28 months . ^^^ Anti apoptotic Bcl 2 and Bcl 10 proteins were also expressed in young rat crura , whereas this expression was lost in old rat crura . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Inhibitors of caspase activity blocked apoptotic cell death , as did overexpression of the apoptosis regulators Bcl 2 or Bcl 10 ( L ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Recent studies suggest that BAD binds to both Bcl 2 and Bcl 10 ( L ) , however mediates its pro apoptotic functions through inhibition of Bcl 10 ( L ) , but not Bcl 2 . ^^^ However , co precipitation assays indicated that , whereas wild type BAD ( BADwt ) directly interacts with Bcl 2 and Bcl 10 ( L ) , BAD ( D119G ) interacts only with Bcl 10 ( L ) . ^^^ Nevertheless both BADwt and BAD ( D119G ) could introduce apoptosis and diminish the anti apoptotic effect of Bcl 2 and Bcl 10 ( L ) in a similar manner in a co transfection assay . ^^^ These data thus suggest that Asp 119 is a crucial site within the BH 3 domain of BAD for interaction of BAD with Bcl 2 , but is dispensable for the interaction of BAD with Bcl 10 ( L ) , for its targeting to mitochondria , and most importantly , for its pro apoptotic functions . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
HHV 8 vFLIP up regulates the expression of Bcl 10 ( L ) , an antiapoptotic member of the Bcl 2 family , which is a known target of the NF kappaB pathway . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In contrast , cytochrome c release from the mitochondria involves dynamic changes in Bcl 2 family proteins ( e . g . up regulation of Bak , Bcl 2 , and Bcl 10 ( L ) ) , opening of permeability transition pore , and loss of mitochondrial membrane potential . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
SRPKs are cleaved in vivo after multiple apoptotic stimuli , and cleavage can be inhibited by overexpression of bcl 2 and bcl 10 ( L ) , and by exposure to soluble peptide caspase inhibitors . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The expression of bcl 10 ( L ) / bcl 10 ( S ) mRNA was examined by RT PCR and the changes of expression of proteins caspase 3 , bcl 2 and PARP were examined by Western blot . ^^^ We also found a decrease of non activated caspase 3 , cleavages of PARP and bcl 2 protein after treatment without fetal bovine serum ( FBS ) by Western blot , but there was no change in the expression of bcl 10 ( L ) / bcl 10 ( S ) mRNA examined by RT PCR during apoptosis . ^^^ Except bcl 10 ( L ) / bcl 10 ( S ) mRNA expression , activation of caspase 3 , cleavage of protein PARP and bcl 2 were all associated with apoptosis . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
BCL 10 ( L ) and BCL 2 delay Myc induced cell cycle entry through elevation of p 27 and inhibition of G 1 cyclin dependent kinases . ^^^ The anti apoptotic molecules BCL 10 ( L ) and BCL 2 delay cell cycle entry from quiescence . ^^^ We used serum induction and induction of a Myc estrogen receptor fusion protein ( MycER ) in quiescent fibroblasts to investigate the mechanisms underlying the cell cycle activity of BCL 10 ( L ) and BCL 2 . ^^^ The cyclin dependent kinase inhibitor p 27 was elevated during serum deprivation and cell cycle entry in BCL 10 ( L ) or BCL 2 expressing NIH3T3 cells and a Rat1MycER cell line . ^^^ Activation of cyclin dependent kinase 2 ( cdk 2 ) and cyclin dependent kinase 4 ( cdk 4 ) were delayed during progression to S phase , while the induction of cyclin D 1 protein , as well as the levels of cyclin E , cdk 2 , and cdk 4 were unaltered by BCL 10 ( L ) or BCL 2 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The levels of anti apoptotic proteins Bcl 2 and Bcl 10 ( L ) were increased , and the cellular levels of pro apoptotic proteins Bid and Bax were reduced . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Using both an immunohistochemical and an immunoblot approach , we found that IL 1 increased the expression of Bcl 2 and decreased that of Bax , while having no effect on the expression of Bclx ( L ) , Fas and CD 40 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
CGP74514A mediated apoptosis was substantially blocked by ectopic expression of full length Bel 2 , a loop deleted mutant Bcl 2 , and Bcl 10 ( L ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The Brn 3a POU family transcription factor is able to induce the expression of genes encoding anti apoptotic proteins such as Bcl 2 and Bcl 10 and protects neuronal cells from apoptosis . ^^^ This effect is opposed by the pro apoptotic p 53 protein which completely inhibits the ability of Brn 3a to activate the Bcl 2 and Bcl 10 promoters . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The release of cytochrome c is the central gate in turning on / off apoptosis , and is regulated by the interaction of proapoptotic proteins , including Bid , Bax and Bak , and antiapoptotic proteins including Bcl 2 and Bcl 10 ( L ) , and a specific class of inhibitors of apoptosis proteins ( IAPs ) including Akt , survivin , and heat shock proteins . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
MATERIALS AND METHODS : We have examined expression of ' survival related ' molecules of the bcl 2 family including bcl 2 and bcl 10 ( L ) , in primary human MCs and the human MC line HMC 1 . ^^^ Results : As assessed by RT PCR , purified unstimulated lung MCs ( > 98 % pure ) exhibited KIT and bcl 10 ( L ) mRNA , but did not express bcl 2 mRNA . ^^^ In fact , exposure of MC to SCF resulted in expression of the bcl 2 protein whereas unstimulated MCs displayed only the bcl 10 ( L ) protein without expressing the bcl 2 protein . ^^^ The human MC leukemia cell line HMC 1 , which contains a mutated and intrinsically activated SCF receptor , showed constitutive expression of both bcl 2 and bcl 10 ( L ) at the mRNA and protein level . ^^^ It is hypothesized that bcl 10 ( L ) plays a role in KIT independent growth of MCs , whereas bcl 2 may be involved in KIT dependent functions of MCs . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In this study , we investigate the contribution of Bcl 2 and Bcl 10 ( L ) to survival and erythroid differentiation by generating stable MEL transfectants expressing these antiapoptotic regulators . ^^^ Overexpression of Bcl 2 completely prevented apoptosis of MEL cells before and after DMSO induction , whereas overexpression of Bcl 10 ( L ) only delayed it . ^^^ Overexpression of Bcl 2 or Bcl 10 ( L ) neither induced spontaneous erythroid differentiation nor accelerated DMSO induced differentiation . ^^^ An antisense oligonucleotide to Bcl 10 ( L ) did not induce apoptosis in MEL cells overexpressing Bcl 2 but greatly decreased their hemoglobin synthesis when treated with DMSO , suggesting that Bcl 10 ( L ) is necessary for erythroid differentiation independently of its antiapoptotic function . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Apoptosis was studied by the terminal deoxynucleotidyl transferase ( TdT ) mediated deoxy UTP nick end labeling ( TUNEL ) method , and immunohistochemistry was used to detect p 53 , caspase 3 and 6 , the antiapoptotic proteins Bcl 2 and Bcl 10 , and the proapoptotic proteins Bax and Bad . ^^^ Bcl 2 and Bcl 10 were present in proliferative and early hypertrophic cells at 2 wk , whereas at older ages a decrease in staining was observed . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We investigated its occurrence and time course in rat hindlimb skeletal muscles during the first 3 weeks of postnatal development , its morphological and biochemical features , and the concomitant expression of Bax , Bcl 2 , and Bcl 10 ( L ) . ^^^ Constitutive levels of Bax , Bcl 2 , and Bcl 10 ( L ) were detected by means of reverse transcriptase polymerase chain reaction ( RT PCR ) analysis at all ages examined , with a moderate increase around the period of maximal apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
While Bcl 2 and Bax expression did not change , Bcl 10 ( L ) was down regulated and Bcl xs was up regulated after being exposed to flavopiridol . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Janus kinase inhibitor AG 490 inhibits Stat 3 activation with a concomitant reduction in steady state levels of Bcl 10 ( L ) , Bcl 2 and Mcl 1 proteins and induces apoptosis in U 251 cells as revealed by Poly ( ADP ribose ) polymerase cleavage and Annexin 5 staining . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 members can either be anti ( Bcl 2 , Bcl 10 ( L ) , Bcl w ) or pro apoptotic ( Bax , Bak , Bid , Bad , Bcl 10 ( S ) ) . ^^^ In contrast , a significant increase was observed in the anti apoptotic member Bcl 2 . mRNA expression of Bcl w , Bad , and Bcl 10 ( L ) was not significantly different between the control and TPN groups . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The expression of anti apoptotic proteins ( Bcl 2 , Bcl 10 ( L ) ) and pro apoptotic proteins ( Bax , Bcl 10 ( S ) , Bad , and Bak ) in response to cryo injury varied in this cell line panel . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Similarities between preparations included : an enhanced ability for both Apo2L / TRAIL preparations to kill a greater relative percentage of HaCaT cells compared with keratinocytes ; enhanced cytotoxicity towards keratinocytes that had their NF B activity inhibited ; a dependence of both Apo2L / TRAIL preparations on FADD and caspase activation ; triggering of the same caspase cascades including caspase 8 and 3 ; and an ability to induce apoptosis even when HaCaT cells and keratinocytes were transduced to overexpress either Bcl 2 or Bcl 10 ( L ) ( survival factors that reduce susceptibility to UV light induced apoptosis ) . ^^^ Moreover , the death receptor pathway triggered by LZ Apo2L / TRAIL can overcome the apoptotic resistance normally observed in response to UV light mediated by Bcl 2 / Bcl 10 ( L ) , as well as by the state of cellular senescence . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Cryptophycin 52 induced phosphorylation of c raf 1 and bcl 2 and / or bcl 10 ( L ) to comparable levels in all cell lines studied , and LNCaP cells overexpressing bcl 2 were more resistant to cryptophycin 52 induced apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Moreover , by modification of anti apoptotic members of the Bcl 2 family ( e . g . upregulation of Bcl 10 ( L ) ) BCR / ABL provides a cytoplasmic ' umbrella ' protecting mitochondria from the ' rain ' of apoptotic signals coming from the damaged DNA in the nucleus , thus preventing release of cytochrome c and activation of caspases . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Here , we report the ability of a novel family of nonnuclear targeted anthracyclines to induce rapid apoptosis in cells despite Bcl 2 or Bcl 10 ( L ) expression . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Using cultured prostate cancer ( PC ) cell lines , LN CaP and ALVA 31 , we studied the effects of 1alpha , 25 ( OH ) 2 Vitamin D 3 ( VD 3 ) on expression of several apoptosis regulating proteins including : ( a ) Bcl 2 family proteins ( Bcl 2 , Bcl 10 ( L ) , Mcl 1 , Bax , and Bak ) ; ( b ) the heat shock protein 70 binding protein BAG1L ; and ( c ) IAP family proteins ( XIAP , cIAP 1 , and cIAP 2 ) . ^^^ VD 3 induced decreases in levels of antiapoptotic proteins Bcl 2 , Bcl 10 ( L ) , and Mcl 1 , BAG1L , XIAP , cIAP 1 , and cIAP 2 ( without altering proapoptotic Bax and Bak ) in association with increases in apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Furthermore , the activity of the pro apoptotic protein Bad ( Bcl 2 / Bcl 10 ( L ) antagonist , causing cell death ) was completely unaffected . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The activation state of protein kinase ERK , which is involved in Ras / MAPK signal transduction pathway mediating cell survival and proliferation , and the expression of anti apoptotic Bcl 2 family proteins Bcl 2 , Bcl 10 ( L ) and Mcl 1 in Sko 007 cells with or without IFNalpha were determined by immunoblot assay . ^^^ In addition , the expression of gp 130 on cell surface , the activation of protein kinase ERK and the expression of Bcl 2 and Bcl 10 ( L ) were all down regualted in IFNalpha stimulated Sko 007 cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Doxorubicin did not affect steady state levels of Bax , Bcl 2 and Bcl 10 ( L ) in the majority of the prostate cancer cell lines . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The release of cytochrome c can be influenced by different Bcl 2 family member proteins , including Bax , Bid , Bcl 2 , and Bcl 10 ( L ) . ^^^ Bax and Bid potentiate cytochrome c release , whereas Bcl 2 and Bcl 10 ( L ) antagonize this event . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We detected a decrease in the expression of bcl 2 and bcl 10 ( L ) , two antiapoptotic proteins that decrease mitochondrial membrane permeability , an increase in cytochrome c immunoreactivity in the cytosolic fraction , and an activation of caspase 9 in brain regions which show apoptotic neurodegeneration following percussion brain trauma in 7 day old rats . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
DES induced the expression of 12 genes ( bad , bax , bcl 10 , caspase 1 , p 53 , cyclin D 3 , GADD 45 , p 21 , p 15 , p 27 , p 57 and Skp 1 ) and down regulated the expression of eight genes ( bcl 2 , caspase 2 , caspase 7 , caspase 8 , E 124 , iNOS , mdm 2 and NFkappab 1 ) at twofold or greater levels . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The mitochondrial localization of the membrane proteins Bcl 2 and Bcl 10 ( L ) is essential for their anti apoptotic function . ^^^ FKBP 38 is associated with Bcl 2 and Bcl 10 ( L ) in immunoprecipitation assays and colocalizes with these proteins in mitochondria ; in addition , the expression of FKBP 38 mutant proteins induces a marked redistribution of Bcl 2 and Bcl 10 ( L ) . ^^^ Thus , FKBP 38 might function to inhibit apoptosis by anchoring Bcl 2 and Bcl 10 ( L ) to mitochondria . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Characterization of the signal that directs Bcl 10 ( L ) , but not Bcl 2 , to the mitochondrial outer membrane . ^^^ It is assumed that the survival factors Bcl 2 and Bcl 10 ( L ) are mainly functional on mitochondria and therefore must contain mitochondrial targeting sequences . ^^^ Here we show , however , that only Bcl 10 ( L ) is specifically targeted to the mitochondrial outer membrane ( MOM ) whereas Bcl 2 distributes on several intracellular membranes . ^^^ These data define a new targeting sequence for the MOM and propose that Bcl 2 acts on several intracellular membranes whereas Bcl 10 ( L ) specifically functions on the MOM . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In MB 468 cells with overexpression of Bcl 2 ( 468 / Bcl 2 ) , FP induced Bax conformational change and apoptosis were inhibited , whereas the FP mediated decline in the levels of IAP proteins , Mcl 11 and Bcl 10 ( L ) remained unaltered . ^^^ Taken together , these findings suggest that the superior sequence dependent anti breast cancer activity of Epo B followed by FP may be due to FP induced Bax conformational change and down regulation of the antiapoptotic IAP , Bcl 10 ( L ) , and Mcl 1 proteins , but this treatment may not overcome the resistance to apoptosis of breast cancer cells conferred by overexpression of Bcl 2 . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
METHODS : Flow cytometry and a panel of antibodies were used to analyze the expression of MDR proteins ( P gp , MRP , LRP , BCRP , GST pi ) and apoptosis modulating proteins ( bcl 2 , bcl 10 , bax , bad ) in MDR cell line HL 60 / VCR and drug sensitive cell line HL 60 . ^^^ The levels of apoptosis modulating proteins ( bcl 2 , bcl 10 , bad ) were ( 2 . 48 , 1 . 25 , 1 . 08 fold ) higher in HL 60 / VCR than in HL 60 , while the pro apoptosis protein bax contrarily decreased in HL 60 / VCR . ^^^ CONCLUSION : Various MDR mechanisms were involved in multi drug resistance HL 60 / VCR cell line , which including increasing expression of drug resistance protein ( P gp , MRP , BCRP , and GST pi ) ; the apoptosis modulating proteins ( bcl 2 , bcl 10 , bax , and bad ) might take part in the mechanism of drug resistance . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We detected apoptosis with the in situ terminal deoxynucleotidyl transferase assay and flow cytometry , and measured the expression of several apoptotic regulatory proteins ( Bcl 2 , Bax , Bclx , NF kappa B ) with Western blotting . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
These events were preceded by selective reduction of mRNAs of NF kappaB dependent , antiapoptotic Bcl 2 family members such as Bcl 10 ( L ) , Bcl 2 and , in particular , A1 / Bfl 1 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Their survival was associated with expression of antiapoptotic cellular FLICE inhibitory protein ( c FLIP ) , Bcl 10 ( L ) , and Bcl 2 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Melanocytic cells expressed relatively high levels of Bcl 2 , Bcl 10 ( L ) , Mcl 1 , C IAP 1 , C IAP 2 , XIAP , Livin , and Apaf 1 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
This increased apoptosis was accompanied by decreased antiapoptotic bcl 2 mRNA expression among bcl 2 related genes ( bcl 2 , bax , bak , mcl 1 , and bcl 10 ( L / S ) ) , and the effect was also more prominent in the cagA ( + ) strains . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
METHODS : We analyzed the expression of four cytoprotective genes , A 20 , Bcl 2 , Bcl 10 ( L ) and heme oxygenase ( HO ) 1 , in three rat renal allograft models of chronic rejection : Fisher 344 Lewis ( F344 / Lew ) , Dark Agouti Brown Norway ( DA / BN ) , and DA Wistar Furth ( WF ) . ^^^ In all combinations , expression of HO 1 , Bcl 2 , and Bcl 10 ( L ) colocalized with infiltrating cells and was not informative on the graft status . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In the present study , we used this system to study the death effects of Bcl 10 ( S ) , a pro apoptotic member of the Bcl 2 family . ^^^ The results showed that expression of Bcl 10 ( S ) in oocytes induces oocyte death by a caspase dependent mechanism , which includes BH 3 dependent cytochrome c release and is inhibited by co expression of the anti apoptotic proteins Bcl 2 and Bcl 10 ( L ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Nonetheless , there were no significant alterations in the level of Bcl 2 , Bcl 10 ( L ) , Bax and Bak by the proteasome inhibitor , nor any evidence of cytochrome ( cyt ) c release into cytosol from dying cells , suggesting that cyt c is not involved . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
However , expression of Bcl 2 or Bcl 10 ( L ) prevents ROS production and subsequent loss of deltapsi ( m ) , thereby inhibiting apoptotic cell death . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Alteration of the expression of Bcl 2 , Bcl 10 , Bax , Fas , and Fas ligand in the involved skin of psoriasis vulgaris following topical anthralin therapy . ^^^ In normal skin , keratinocytes expressed low to absent levels of Bcl 10 and Bax , while Bcl 2 was detected only in melanocytes in basal layers . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Fifty excisional biopsy samples were studied by immunohistochemical technique for the differential expressions of bcl 2 , bax , bcl 10 and alpha smooth muscle actin . ^^^ Bcl 2 , bcl 10 and bax were expressed in 34 ( 68 % ) , 38 ( 76 % ) and 41 ( 82 % ) specimens , respectively . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
EXPERIMENTAL DESIGN : We investigated proteins involved in regulation of apoptosis ( p 53 , BAX , BCL 2 , and BCL 10 ( L ) ) , cell cycle control [ p 21 and retinoblastoma protein ( RB ) ] , and drug export and inactivation [ P glycoprotein , multidrug resistance associated protein ( MRP ) 1 , MRP 2 , breast cancer resistance protein , lung resistance protein , metallothionein , and glutathione S transferase pi ] immunohistochemically in samples of unselected GCT patients ( n = 20 ) , patients with advanced metastatic disease in continuous remission after first line chemotherapy ( n = 12 ) , and chemotherapy refractory patients ( n = 24 ) . ^^^ The levels of the antiapoptotic proteins BCL 2 and BCL 10 ( L ) were generally low . p 21 was hardly detectable and did not correlate with p 53 ( r ( s ) = 0 . 29 ; P = 0 . 07 ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 , bax and bcl 10 protein expression were detected by standard avidin biotin peroxidase method . ^^^ Bcl 2 , bax and bcl 10 expression were detected in 84 % , 80 % , and 76 % , respectively , of normal squamous mucosa . ^^^ Pre therapeutic bcl 2 , bax and bcl 10 protein expression ( 27 % , 75 % , and 87 . 5 % , respectively ) were not associated with tumor response or resistance to therapy . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We did not observe a protective effect of Bcl 10 ( L ) or Bcl 2 against the cytotoxic activity of TRAIL , even though TRAIL induced cleavage of BID . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Induction of monocytic differentiation led to marked upregulation of the IAP protein XIAP , as well as the Bcl 2 family member Bcl 10 ( L ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Finally , BCL 2 and BCL 10 ( L / S ) expression levels were analyzed in cells exposed to 1 h ischemia followed by 12 h reperfusion in the presence or not of SB 202190 ; BCL 2 , but not BCL 10 ( L / S ) , expression was decreased in ROS treated cells but SB 202190 failed to restore BCL 2 level . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Apoptosis involved the mitochondrial pathway with decreased levels of Bcl 2 and Bcl 10 ( L ) protein , release of cytochrome c , and increased caspase 3 activity . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Mouse uterine epithelial apoptosis is associated with expression of mitochondrial voltage dependent anion channels , release of cytochrome C from mitochondria , and the ratio of Bax to Bcl 2 or Bcl 10 . ^^^ In addition , the apoptotic index showed good correlation with the release of cytochrome c from mitochondria , activation of caspase 3 , which was immunohistochemically detected only in the epithelium , and the mRNA and protein ratios of Bax : Bcl 2 and Bax : Bcl 10 in the uterus . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The molecular mechanisms underlying the initiation and control of the release of cytochrome c during mitochondrion dependent apoptosis are thought to involve the phosphorylation of mitochondrial Bcl 2 and Bcl 10 ( L ) . ^^^ Although the c Jun N terminal kinase ( JNK ) has been proposed to mediate the phosphorylation of Bcl 2 / Bcl 10 ( L ) the mechanisms linking the modification of these proteins and the release of cytochrome c remain to be elucidated . ^^^ Taken together , JNK dependent phosphorylation of mitochondrial proteins including , but not limited to , Bcl 2 / Bcl 10 ( L ) may represent a potential of the modulation of mitochondrial function during apoptosis . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The overexpression of bcl 2 or bcl 10 ( L ) in FL5 . 12 cells inhibited apoptosis induced by MK 886 as well as the enhancement of apoptosis by WY 14643 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The expression of Bcl 2 family proteins ( Bcl 2 , Bax and Bcl 10 ( L ) ) was analyzed by flow cytometry showing high expression of the three proteins which was not significantly modified after treatment with either PSC 833 or CsA on the sensitive as well as on the resistant cell lines . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Immunoreactivity for parathyroid hormone related peptide ( PTHrP ) , caspase 3 , and the anti apoptotic proteins Bcl 2 and Bcl 10 was also studied . ^^^ Increased apoptosis after dexamethasone treatment was accompanied by increased immunoreactivity for caspase 3 and decreased immunoreactivity for the anti apoptotic proteins Bcl 2 and Bcl 10 , which further supports our apoptosis results . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Precursors from aged animals were deficient in ability to modulate expression of apoptosis regulatory genes Bax , Bcl 2 , and Bcl 10 in comparison to B cell precursors from young animals . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The level of endoplasmic reticulum Ca ( 2+ ) binding chaperones ERp 57 and ERp 72 and of anti apoptotic proteins Bcl 2 and Bcl 10 ( L ) was decreased whereas that of Ca ( 2+ ) binding protein calmodulin and the stress protein HSP 60 was elevated following ALA PDT . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
METHODS : Immunohistochemical analysis of Bax , Bcl 2 , and Bcl 10 ( L ) was performed in tissue specimens of patients with RA and compared to normal synovial tissue . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Accordingly , we found that SCF up regulates Bcl 2 and Bcl 10 L in erythroid precursors and that exogenous expression of these proteins protects erythroblasts from caspase activation and death induced by chemotherapeutic agents . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The anti apoptotic Bcl 2 family protein Bcl 10 ( L ) is induced by dexamethasone at the transcriptional level at all stages of fibrosarcoma development . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
This phenomenon of `` accommodation ' ' is associated with expression of protective genes such as bcl 2 , bcl 10 ( L ) , and heme oxygenase 1 . ^^^ We observed significant protein expression of bcl 2 , bcl 10 ( L ) , and heme oxygenase 1 in cardiac xenografts treated with CVF+CsA at 2 , 14 , and 21 days after transplantation , compared with normal hamster hearts . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We found that increased expression of Bcl 10 ( L ) , but not Bcl 2 , suppressed TRAIL induced apoptosis in tumour cells . ^^^ Western blot and immunohistochemical analyses showed that expression of Bcl 10 ( L ) , but not Bcl 2 , was highly increased in human breast cancer tissues . ^^^ Forced expression of Bcl 10 ( L ) , but not Bcl 2 , desensitised TRAIL sensitive MDA MB 231 cells to TRAIL . ^^^ Similar inhibitory effects were also observed in other tumour cells such as HeLa and Jurkat cells stably expressing Bcl 10 ( L ) , but not Bcl 2 . ^^^ These results are indicative of the crucial and distinct function of Bcl 10 ( L ) and Bcl 2 in the modulation of TRAIL induced apoptosis . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
MPP ( + ) increased levels of Bax , Bcl 2 and Bcl 10 ( L ) proteins approximately 2 fold over 24 hr , with Bax increases occurring first ; Bax did not increase in rho ( 0 ) cells . ^^^ The Bax increase , but not that of Bcl 2 or Bcl 10 ( L ) , was dependent on nitric oxide ( NO ) and seemed post transcriptional . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The long term NO generator diethylenetriamine NO ( DETA NO ) reproduced the post transcriptional Bax protein increase , but did not increase Bcl 2 or Bcl 10 ( L ) proteins . ^^^ Inducible overexpression ( approximately 2 fold ) of Bcl 2 or Bcl 10 ( L ) proteins reduced MPP ( + ) or NO induced apoptosis but did not affect cell death . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
These data suggest that during apoptosis , cytochrome c is nitrosylated in mitochondria and then rapidly released into the cytoplasm in the absence of Bcl 2 or Bcl 10 ( L ) overexpression . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Detailed studies in L 3055 demonstrated that this activity was mediated by induced apoptosis and confirmed by observations that overexpression of the antiapoptotic genes bcl 2 or bcl 10 ( L ) conferred significant protection against the drugs . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
This review focuses on novel strategies to induce apoptosis in glioma cells by transduction with adenoviral vectors carrying a variety of apoptosis related genes , including Fas ligand , Fas , FADD , caspase 8 , p 53 , p33ING1 , p73alpha , Bax , Apaf 1 , caspase 9 , IkappaBdN , caspase 3 , Bcl 2 , and Bcl 10 ( L ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The paraquat mediated gene or protein expression of proapoptotic Bax , Bcl w , and Bcl 10 ( S ) , cell survival / death factors GADD 45 , MDM 2 , c Myc , and caspase 3 was upregulated , but that of antiapoptotic Bcl 2 was downregulated in the GPX 1 / mice vs . the WT mice . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Molecular markers of outcome after radiotherapy in patients with prostate carcinoma : Ki 67 , bcl 2 , bax , and bcl 10 . ^^^ The current study examined the association between expression levels of Ki 67 , bcl 2 , bax , and bcl 10 in pretreatment biopsy specimens and patient outcome after definitive radiotherapy alone . ^^^ Expression levels of Ki 67 ( MIB 1 staining ; n = 106 patients ) , bcl 2 ( n = 77 patients ) , bax ( n = 70 patients ) , and bcl 10 ( both long and short splice variants ; n = 72 patients ) were determined by immunohistochemical staining . ^^^ RESULTS : High Ki 67 LI ( > 3 . 5 % ) expression was observed in 33 % of patients , overexpression of bcl 2 was observed in 16 % of patients , altered bax expression was observed in 23 % of patients , and altered bcl 10 expression was observed in 53 % of patients . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
These genes include cyclooxygenase 2 ( COX 2 ) , Bcl 2 , BclX ( L ) and c Myc , which influence diverse processes such as angiogenesis , proliferation and apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Peripheral immune cells were investigated for apoptosis and for the expression of apoptosis regulatory genes CD 95 , CD 95 ligand , FLIP , Bcl 2 , Bcl 10 ( L ) , Bag 1 , and caspase 3 by quantitative real time PCR . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
To dissect apoptotic genes governing the survival of colorectal carcinoma cells , we employed RNAi to silence Bcl 2 and Bcl 10 ( L ) in isogenic clones of p53+ / + and p 53 / cells , and of Bax+ / and Bax / cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
To examine p 75 ( NTR ) dependent apoptosis in tumor cells , we demonstrated that a dose dependent increase in p 75 ( NTR ) expression was associated with a concomitant increase in the mitochondrial proapoptotic effector proteins Bad , Bax and Bik and a decrease in the mitochondrial prosurvival effector proteins phospho Bad , Bcl 2 and Bcl 10 ( L ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The induction of apoptosis by IL 21 correlates with a down regulation in the expression of Bcl 2 and Bcl 10 ( L ) , two antiapoptotic members of the Bcl 2 family . ^^^ Furthermore , the reconstitution of Bcl 10 ( L ) or Bcl 2 expression protects primary B cells from IL 21 induced apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We therefore developed a four color flow cytometry method that enables establishment of apoptosis related protein expression such as Bcl 2 , Bcl 10 ( L ) , Mcl 1 and Bax at diagnosis and in MRD . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Immunohistochemistry was used on paraffin sections to detect LMP 1 / EBV , CD 15 and the apoptosis related proteins ( bcl 2 , bax , bcl 10 , mcl 1 and CD 95 ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Our results revealed that the expression of bcl 2 and bcl 10 ( L ) decreased after 5 and 3 h p . i . , respectively ; while bax and procaspase 3 expression increased with respect to control as a function of p . i . times and at 7 h p . i . they were not observed . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We observed downregulation of the expression of inhibitors of apoptosis proteins ( IAPs ) Bcl 2 , Bcl 10 ( L ) , and survivin and upregulation of pro apoptotic p 53 and Bax as assessed by Western blotting . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Comparison of the anti apoptotic effects of Bcr Abl , Bcl 2 and Bcl 10 ( L ) following diverse apoptogenic stimuli . ^^^ Ectopic expression of Bcr Abl , Bcl 2 or Bcl 10 ( L ) in HL 60 cells conferred resistance to apoptosis against a variety of death inducing agents . ^^^ Our findings show that Bcr Abl is a more powerful anti apoptotic molecule than Bcl 2 or Bcl 10 ( L ) . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
These cells demonstrated reduced expression of Bcl 2 , Bcl 10 ( L ) , cyclin A 2 , and cyclin B 1 , with increased apoptosis and delayed cell cycle progression during IL 3 or SCF culture . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We have analyzed 2 antiapoptotic proteins , Bcl 2 and Bcl 10 , by Western blot and immunohistochemistry screening for differential expression in control and SMA fetal spinal cords . ^^^ At 15 weeks , motor neurons of SMA fetuses showed a marked decrease in the levels of Bcl 2 and a delay in the expression of Bcl 10 in comparison with controls . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We previously reported that the leukemic cell death induced by an N terminally truncated Bax ( deltaN Bax : corresponding to amino acid 112 192 of full length Bax ) was not blocked by Bcl 2 or Bcl 10 ( L ) owing to the lack of the BH 3 domain needed to interact with the antiapoptotic Bcl 2 family molecules . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Rescue from apoptosis was associated with the up regulation of Bcl 2 in both cell types , whereas elevated expression of Bcl 10 ( L ) was observed among CD 44 ( high ) but not CD 44 ( low ) CD 8 ( + ) cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We examined the impact of beta AR blockade with metoprolol on myocardial remodeling , apoptosis , pro apoptotic ( Fas , Fas ligand , Bax , and Bcl 10 ( S ) ) and anti apoptotic ( Bcl 10 ( L ) and Bcl 2 ) gene expression , and Bcl 10 ( L ) and Bcl 10 ( S ) protein in post infarction HF in rats . ^^^ Metoprolol treatment resulted in : ( 1 ) improved LV remodeling ( P < 0 . 025 ) , ( 2 ) reduced myocardial apoptosis ( P < 0 . 005 ) , and ( 3 ) selective reduction in myocardial Bcl 10 ( S ) expression ( P < 0 . 001 ) without change in Fas , Fas ligand , Bax , Bcl 2 , or Bcl 10 ( L ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Additionally , the proteins of the p 53 regulated genes , p 21 ( WAF 1 ) and Bax , were increased with a similar time , while Bcl 2 and Bcl 10 ( L ) expression was lowered . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The objective was to evaluate the immunohistochemical expression of p 53 , p 21 , bax , bak , fas , bcl 2 and bcl 10 proteins in 10 endometriomas , 20 benign ovarian tumours ( 10 mucinous , 10 serous ) and 30 malignant ovarian tumours ( 9 mucinous , 19 serous ; 2 endometrioids ) . p 53 positive cells ( mean+ / SD ) in endometriomas , and benign and malignant tumours were 1 . 9+ / 3 . 2 , 0 and 16 . 2+ / 33 . 0 , respectively . ^^^ No difference in bak , fas , bcl 2 or bcl 10 expression was observed among the groups . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
TGF beta did not impair proximal signaling by Shc or STAT 5 , and induction of some downstream genes , including cytokine inducible Src homology 2 containing protein ( CIS ) , bcl 10 ( L ) , and bcl 2 , was spared . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
It was revealed that LIGHT treatment resulted in down regulation of anti apoptosis Bcl 2 family member : Bcl 2 , Bcl 10 ( L ) , Bag 1 , and Mcl 1 ; up regulation of pro apoptosis Bcl 2 family member : Bak and Ser ( 112 ) phosphor Bad ; down regulation of pro apoptosis Bcl 2 member Bax ; the other pro apoptosis member Bid remains unaltered . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
One may assume that taxanes are able to induce the phosphorylation of Bcl 10 ( L ) / Bcl 2 members and thus inactivate their anti apoptotic capacities . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Prosurvival members such as Bcl 2 and Bcl 10 ( L ) are supposed to preserve mitochondrial outer membrane integrity , thus preventing the release of soluble apoptogenic molecules . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
A 24 h exposure of PC 3 and LNCaP cells to an apoptosis inducing concentration of AITC ( 20 micro M ) resulted in a significant decrease ( 31 68 % ) in the levels of anti apoptotic protein Bcl 2 in both cell lines , and approximately 58 % reduction in Bcl 10 ( L ) protein expression in LNCaP cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
All ' multidomain ' anti apoptotic members ( Bcl 10 , Bcl 2 , Mcl 1 , Bcl w and Bcl2l10 / Diva / Boo ) except Bcl2a1 / A1 are expressed in OLC . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We also analyzed the relationship between TCF 4 gene splicing isoforms , proliferation ( proliferating cell nuclear antigen labeling index ) , and apoptosis [ antiapoptotic factors ( Bcl 2 and Bcl 10 ( L ) ) , proapoptotic factors ( Bak and Bax ) , and caspase 3 ] in RCC samples . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
PURPOSE : We hypothesized that apoptosis is a downstream event in erectile dysfunction , and pro apoptotic ( Bak and Bax ) and anti apoptotic ( Bcl 2 and Bcl 10 ) factors are involved in the etiology of diabetes induced erectile dysfunction . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
To determine the molecular order among these events , we introduced inhibitors of LMP ( bafilomycin A ( 1 ) ) , MMP ( Bcl 10 ( L ) , wild type Bcl 2 , mitochondrion targeted Bcl 2 , or viral mitochondrial inhibitor of apoptosis from cytomegalovirus ) , and caspases ( Z VAD . fmk ) into the system . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In both cases , Bcl 2 expression was consistently down regulated , whereas levels of other members of the Bcl 2 family , such as Bax and Bcl 10 , did not change in paclitaxel resistant cell lines . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
METHODS : The expressions of apoptosis associated genes ( bcl 2 , bax , bcl 10 ( L ) and bcl 10 ( S ) ) and the activity of caspase 3 were studied by reverse transcription polymerase chain reaction ( RT PCR ) and western blot in the cisplatin resistant ( A2780 / DDP , COC1 / DDP ) and sensitive human ovarian cancer cells ( A 2780 and COC 1 ) . ^^^ RESULTS : The mRNA expressions of bcl 2 and bcl 10 ( L ) in A2780 / DDP cells were 1 . 87 + / 0 . 25 and 1 . 73 + / 0 . 15 , and significantly higher than those in A 2780 cells ( P < 0 . 05 ) , which were 1 . 48 + / 0 . 14 and 1 . 41 + / 0 . 19 respectively . ^^^ The protein expressions of bcl 2 and bcl 10 ( L ) in A2780 / DDP cells were 1 . 99 + / 0 . 11 and 1 . 69 + / 0 . 16 , and significantly higher than those in A 2780 cells ( P < 0 . 05 ) , which were 1 . 51 + / 0 . 17 and 1 . 28 + / 0 . 11 respectively . ^^^ The expressions of bcl 2 and bcl 10 ( L ) in COC1 / DDP cells were also significantly higher than those in COC 1 cells ( P < 0 . 05 ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Apoptosis was associated with the down regulation of bcl 2 family members bcl 10 ( L ) and bfl / A1 , and the activation of caspase 3 , that mediates bcl 2 cleavage , resulting in the release of cytochrome c from the mitochondria . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
With a serial of Western blot analysis , it is revealed that gossypol induced cell cycle arrest is involved in P 21 up regulation and cyclin D 1 down regulation ; gossypol induced apoptosis triggers down regulation of anti apoptosis Bcl 2 members : Bcl 10 ( L ) , Bag 1 and Mcl 1 , up regulation of pro apoptosis Bcl 2 member Bak , activation of caspase 3 , 6 , 7 , 8 , and 9 , up regulation of Apaf 1 , release of cytochrome c ( cyto c ) from mitochondria , and activation of both DFF 45 and PARP . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Here , we found that HDB induced apoptotic cell death was accompanied by upregulation of cyclin D 3 , Bax , and p 21 and down regulation of Bcl 10 ( L ) , while HDB had no effect on the levels of Bcl 2 and Bad protein . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In these conditions , microscopic analysis revealed chromatin condensation in dying cells and the Bcl 2 , Bcl 10 ( L ) / Bax mRNA balance was altered . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Furthermore , the association of RelA expression with tumor cell apoptosis , proliferation , and expression of Bcl 2 / Bcl 10 ( L ) was also studied . ^^^ METHODS : Paraffin sections were stained with monoclonal antibodies directed against RelA , Bcl 2 , Bcl 10 ( L ) , and Ki 67 to assess protein expression patterns in normal , adenomatous and colon cancer tissue . ^^^ RESULTS : The results of immunohistochemical staining revealed that expression of RelA , Bcl 2 , Bcl 10 ( L ) , and Ki 67 labeling index ( LI ) significantly increased in the transition from adenoma with low dysplasia to adenocarcinoma . ^^^ The expression of RelA correlated inversely with the AI and correlated positively with the expression of Bcl 2 , Bcl 10 ( L ) , and Ki 67 LI in the transition from low grade dysplasia to adenocarcinoma . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Accompanying the drug resistance , high levels of anti apoptotic Bcl 10 ( L ) and Bcl 2 proteins were found in the mitochondria containing fraction of IL 2Ralpha expressing tumor cells . ^^^ Treatment of IL 2Ralpha expressing cells with a specific Janus kinase 3 ( Jak 3 ) inhibitor decreased expression of cyclin A , cyclin D 1 , Bcl 10 ( L ) , and Bcl 2 proteins . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Antiapoptotic proteins of the Bcl 2 family such as Bcl 2 and Bcl 10 ( L ) are also expressed but , in contrast to c FLIP , c IAP , and 10 chromosome linked IAP , do not appear to be tightly regulated by the presence of the parasite . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
There was no difference found in the expression of proapoptotic ( Bax and Bcl 10 ( s ) ) or antiapoptotic ( Bcl 2 and Bcl 10 ( L ) ) genes nor in the expression of the tumor suppressor gene p 53 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The defective apoptosis seen in human cancers often results from overexpression of antiapoptotic proteins in the Bcl 2 protein family , particularly Bcl 2 and Bcl 10 ( L ) . ^^^ In addition , detailed knowledge of the structures of Bcl 2 and Bcl 10 ( L ) , coupled with high throughput and computer assisted screening of chemical libraries , has led to the identification of a number of short peptides and small organic molecules capable of inhibiting Bcl 2 and Bcl 10 ( L ) function . ^^^ These newly described agents hold considerable promise for enhancing the chemo and radiation sensitivities of Bcl 2 and Bcl 10 ( L ) overexpressing cancers . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Similar BCL 10 but different BCL 2 levels in the two age groups of north African nasopharyngeal carcinomas . ^^^ As Bcl 2 and Bcl 10 are co expressed in EBV transformed B lymphocytes , we attempted to determine their status in malignant NPC cells . ^^^ Bcl 2 and Bcl 10 expression was assessed semi quantitatively using a score based on the percentage of positive cells and staining intensity . ^^^ Bcl 10 and Bcl 2 are co expressed in 89 % of NPCs whereas their expression is mutually exclusive in other head and neck carcinomas ( particularly squamous cell carcinomas , SCC ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The levels of B cell leukaemia / lymphoma 2 ( Bcl 2 ) , but not those of Bcl 2 associated 10 protein ( Bax ) or Bcl 10 ( L ) , were down regulated concentration dependently by magnolol . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
To further understand such merosin driven survival signaling , we analyzed the expression of five Bcl 2 homologs ( Bcl 2 , Bcl 10 ( L ) , Bax , Bak , Bad ) and one non homologous associated molecule ( Bag 1 ) in normal and merosin deficient myotubes , with or without pharmacological inhibitors for Fyn and p 38 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In the present study , we investigated whether inhibition of DEX induced apoptosis by PRL in Nb 2 T cells was accompanied by altered expression of Bcl 2 family members , mcl 1 , bad or bcl 10 ( L ) determined by Northern and immunoblot analysis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Sequential up regulation of FLIP ( FLICE like inhibitory protein ) , but not Bcl 2 , Bcl 10 ( L ) or inhibitors of apoptosis protein ( IAPs ) , was observed in resistant cells but not in parental cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
However , IL 15 and IL 2 induce comparable levels of Bcl 2 and Bcl 10 ( L ) in SOCS 1 deficient and SOCS 1 sufficient CD8+ T cells , suggesting that cytokine receptor signals required for inducing proliferation and cell survival signals are not identical . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
FL5 . 12 pro B lymphoma cells utilize the mitochondrial pathway to apoptosis in response to tumor necrosis factor ( TNF ) receptor occupation , yet high levels of the Bcl 2 family antiapoptotic protein , Bcl 10 ( L ) , fail to protect these cells against TNF receptor activated death . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
As ( 2 ) O ( 3 ) induced apoptosis was associated with reduced deltapsi ( m ) , enhanced generation of intracellular ROS , decreased levels of intracellular GSH , release of cytochrome c and AIF from the mitochondria , activation of caspases , down regulation of Bcl 2 and Bcl 10 ( L ) , and up regulation of Bax expression . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
To determine the effect of genistein on some NF kappa B target gene products , we examined the antiapoptotic proteins Bcl 2 , Bcl 10 ( L ) , A 1 , and cIAP 1 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Our findings suggest that these natural products bind and antagonize the antiapoptotic effects of B cell lymphocyte / leukemia 2 ( Bcl 2 ) family proteins such as Bcl 10 ( L ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The crystal structure of mouse Bcl 10 ( L ) bound to a long helical fragment of Bim indicates that the structure of Bim is very different from proteins with a Bcl 2 like fold and may leave the BH 3 region of Bim constitutively exposed . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The lack of an exposed , pre formed binding groove in BHRF 1 and the lack of significant binding to peptides derived from pro apoptotic family members that bind to other anti apoptotic family members , suggest that the mechanism of the BHRF 1 anti apoptotic activity does not parallel that of cellular Bcl 10 ( L ) or Bcl 2 . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Also , it prevented the H ( 2 ) O ( 2 ) mediated mitochondrial dysfunction , including disruption of mitochondria membrane permeability transition as well as an increase in expression of apoptogenic Bcl 2 proteins , Bcl 2 and Bcl 10 ( L ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Increased expression of Bcl 2 and Bax , but not of Bcl 10 , occurs in the penumbra at the time when Bax translocates from the cytosol to the mitochondria , cytochrome c is released to the cytoplasm and active caspase 3 is expressed . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In normal cells , and in precancerous B cells of E micro myc transgenic mice , this apoptotic response is associated with the suppression of the antiapoptotic regulators Bcl 2 and Bcl 10 ( L ) and with the concomitant induction of Puma , a proapoptotic BH 3 only protein . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Examination of Bcl 2 , Bcl 10 and bax protein expression in psoriasis . ^^^ METHODS : Twenty six lesional biopsy samples of 26 patients with psoriasis and five control specimens from normal skin were studied by immunohistochemical method for the differential expression of pro apoptotic bax and antiapoptotic bcl 2 and bcl 10 proteins . ^^^ RESULTS : Compared with the normal epidermis , bcl 2 expression was significantly reduced , whereas bax and bcl 10 were significantly overexpressed in the psoriatic epidermis . ^^^ The localization of bcl 2 / bax / bcl 10 proteins in the psoriatic epidermis did not show a significant deviation from that in the normal epidermis . ^^^ CONCLUSION : These findings indicate a discordant expression of bcl 2 and bax / bcl 10 in psoriatic epidermis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 10 ( L ) and Bcl 2 inhibit both apoptosis and proliferation . ^^^ In investigating the relationship between these two functions of Bcl 10 ( L ) and Bcl 2 , an analysis of 24 Bcl 10 ( L ) and Bcl 2 mutant alleles , including substitutions at residue Y 28 previously reported to selectively abolish the cell cycle activity , showed that cell cycle delay and anti apoptosis co segregated in all cases . ^^^ In determining whether Bcl 2 and Bcl 10 ( L ) act in G ( 0 ) or G ( 1 ) , forward scatter and pyronin Y fluorescence measurements indicated that Bcl 2 and Bcl 10 ( L ) cells arrested more effectively in G ( 0 ) than controls , and were delayed in G ( 0 ) G ( 1 ) transition . ^^^ The cell cycle effects of Bcl 2 and Bcl 10 ( L ) were reversed by Bad , a molecule that counters the survival function of Bcl 2 and Bcl 10 ( L ) . ^^^ When control and Bcl 10 ( L ) cells of equivalent size and pyronin Y fluorescence were compared , the kinetics of cell cycle entry were similar , demonstrating that the ability of Bcl 10 ( L ) and Bcl 2 cells to enhance G ( 0 ) arrest contributes significantly to cell cycle delay . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
METHODS : TUNEL staining , immunohistochemical staining for Ki 67 , p 53 , Bcl 2 , Bcl 10 ( L ) and Bax were performed on paraffin embedded specimens obtained from 11 H . pylori negative controls , 20 H . pylori positive chronic gastritis , 10 chronic gastritis with intestinal metaplasia ( IM ) , 11 adenoma , and 7 adenocarcinoma patients . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Although expression of Bcl 2 and Bcl 10 ( L ) decreased in a time dependent manner under serum deprivation , treatment with TNF alpha protected Prnp ( / ) neuronal cells from serum deprivation with an increase in anti apoptotic proteins Bcl 2 and Bcl 10 ( L ) . ^^^ Nuclear morphological analysis using fluorescence microscopy and flow cytometry analysis showed that gene transfer of bcl 2 or bcl 10 ( L ) significantly inhibited apoptosis induced by serum deprivation . ^^^ These findings indicate that TNF alpha attenuated cell death of Prnp ( / ) neuronal cells by induction of Bcl 2 and Bcl 10 ( L ) , and that decreases in Bcl 2 and Bcl 10 ( L ) played crucial roles in the apoptosis of Prnp ( / ) neuronal cells . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Treatment with SBHA also resulted in down regulation of antiapoptotic members of the Bcl 2 family , Bcl 10 ( L ) and Mcl 1 , and the IAP member , XIAP . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Furthermore , we demonstrate that CED 4 not only interacts with Bcl 10 ( L ) but also with its homologue , Bcl 2 , and that the unstructured loop region present in Bcl 10 ( L ) and Bcl 2 can regulate the CED 4 interaction . ^^^ Lastly , we show that a BH 3 peptide that can inhibit Bcl 2 family interactions also inhibits the interaction between Bcl 10 ( L ) and CED 4 . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
It induced apoptosis as shown by : ( 1 ) decreased Bcl 2 and Bcl 10 ( L ) proteins and increased Bax protein ; ( 2 ) activation of caspase 3 ; and ( 3 ) increased shedding of apoptotic cells in the medium . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
These experiments demonstrate that Bz 423 has cytotoxic activity against all B cell lines tested , regardless of EBV status or Bcl 2 and Bcl 10 ( L ) expression levels . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Antiapoptotic family proteins such as Bcl 2 and Bcl 10 ( L ) function , at least in part , by binding proapoptotic members such as Bax and Bak and thereby preventing release of apoptotic proteins , including cytochrome c , from the mitochondria . `` BH 3 only ' ' members of the family disrupt this interaction by binding , via their BH 3 domain , to a hydrophobic pocket on the surface of the antiapoptotic members . ^^^ The assays are designed using tags such that different Bcl 2 family members or BH 3 domain peptides can be readily applied to either format , as exemplified by the use here of histidine tagged Bcl 10 ( L ) and biotinylated BH 3 peptides . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Further , chemotherapy did not cause a compatible change in expression levels of proteins such as Bcl 2 , Bcl 10 ( L ) , Bax , cIAP 2 , XIAP and survivin . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Conversely , overexpression of Bcl 2 or Bcl 10 ( L ) completely inhibits the initiation of apoptosis , indicating that 15d PGJ ( 2 ) mediated apoptosis involves activation of the mitochondrial pathway . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 10 ( L ) , a member of the Bcl 2 family , blocks apoptosis and has been reported to increase in Barrett ' s associated neoplasia . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
This family of proteins now includes both anti apoptotic molecules such as Bcl 2 and Bcl 10 ( L ) , and pro apoptotic molecules such as Bax , Bak , Bid , and Bad . ^^^ The majority of human cancers are found to have overexpression of Bcl 2 , Bcl 10 ( L ) , or both . ^^^ Bcl 2 and Bcl 10 ( L ) may play a critical role in cancer progression . ^^^ Cancers with high levels of Bcl 2 or Bcl 10 ( L ) or both proteins are resistant to a wide spectrum of chemotherapeutic agents and radiation therapy . ^^^ Bcl 2 and Bcl 10 ( L ) have become attractive targets for designing new anticancer drugs . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Reduced beta cell apoptosis resulted from elevated Bcl 2 and Bcl 10 ( L ) activity and diminished caspase 9 activity , indicating a novel role for a mitochondrial dependent pathway of beta cell death . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Here , we found that Bik mutants , in which threonine 33 and / or serine 35 were changed to aspartic acid to mimic the phosphorylation at these two residues , enhanced their binding affinity with the antiapoptotic proteins Bcl 10 ( L ) and Bcl 2 and were more potent than wild type Bik in inducing apoptosis and inhibiting cell proliferation in various human cancer cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Ether lipid resistant S49ar cells were cross resistant to extracellular stress factors ( cold shock , heat shock , H2O2 , dimethylsulfoxide ) and to radiation induced apoptosis but not to physiological apoptotic signals ( dexamethasone , growth factor deprivation , thapsigargin , C 2 ceramide ) and expressed similar levels of the apoptosis regulating proteins Bcl 2 , Bcl 10 , Bax , Bad and Bak as did the parent S49wt cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In this study , we have evaluated the Bcl 2 homologue , Bcl 10 ( L ) and compared its effectiveness to a Bcl 10 ( L ) mutant lacking most of the non conserved unstructured loop domain , Bcl 10 ( L ) Delta ( deletion of amino acids 26 through 83 ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
This includes well established events such as activation of BCL 2 via translocations in follicular lymphoma , as well as more recent observations implicating activation of Bcl 10 ( L ) expression and frameshift and missense mutations of BAX and BCL 2 in cancer . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Both keratinocytes and keratinocyte cell lines express rather low levels of the anti apoptotic proteins bcl 2 and bcl 10 compared to other apoptosis resistant cell types . ^^^ The differences between keratinocytes and keratinocyte cell lines in susceptibility to apoptosis are not explained by difference in expression of bcl 2 or bcl 10 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 and Bcl 10 ( L ) differentially protect human prostate cancer cells from induction of apoptosis by melanoma differentiation associated gene 7 , mda 7 / IL 24 . ^^^ A potential functional role for changes in bcl 2 family gene expression in Ad . mda 7 induced apoptosis was suggested by the finding that forced overexpression of bcl 10 ( L ) or bcl 2 differentially diminished the apoptotic effect of Ad . mda 7 in prostate carcinomas . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Examination of apoptosis related proteins by immunoblot analysis revealed levels of BCL 2 , BCL 10 ( L ) , and Bax to be unaffected by celecoxib . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Expression of thymidylate synthase , thymidine phosphorylase , dihydropyrimidine dehydrogenase , E2F 1 , Bak , Bcl 10 , and Bcl 2 , and clinical outcomes for gastric cancer patients treated with bolus 5 fluorouracil . ^^^ We investigated the relationship between the expression of thymidylate synthase ( TS ) , thymidine phosphorylase ( TP ) , dihydropyrimidine dehydrogenase ( DPD ) , E2F 1 , Bcl 2 , Bak , and Bcl 10 , and the chemotherapeutic effects of sequential MTX / 5FU . ^^^ Immunohistochemical reactivity was defined as positive when over 25 % of cancer cells showed strong staining in the cytoplasm for TS , TP , DPD , Bak , Bcl 2 , and Bcl 10 , and in the nucleus for E2F 1 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
RESULTS : Specimen slides showed an increase in cells staining positively for anti apoptotic proteins Bcl 2 and Bcl 10 . ^^^ An average of 6 . 5 % of specimen cells were positive for Bcl 2 and 10 . 4 % for Bcl 10 . ^^^ Control tissue showed only 1 . 1 % of cells to be positive for Bcl 2 and 1 . 2 % for Bcl 10 . ^^^ Odontogenic myxoma tumor cells showed increased expression of antiapoptotic proteins ( Bcl 2 and Bcl 10 ) and the matrix metalloproteinase MMP 2 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Among them , Bcl 10 ( L ) , which is structurally similar to Bcl 2 and functions as an antiapoptotic molecule , is involved in diseases such as ischemic heart diseases and heart failure . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In addition , ectopic expression of mitochondrial antiapoptotic Bcl 2 , Bcl 10 ( L ) , or inactive caspase 9 short form suppressed DeltaTau 1 toxicity . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Ectopic expression of Bcl 2 and Bcl 10 ( L ) inhibits mitochondrial changes , ROS production , and apoptosis providing additional support for an association between mitochondrial dysfunction and Ad . mda 7 action . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Inhibition of the NO production led to decreased rate of apoptosis accompanied by downregulation of the proapoptotic molecule Bax and increased expression of the antiapoptotic molecule Bcl 2 and Bcl 10 ( L ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Lethal effects were significantly diminished in U 937 cells ectopically expressing dominant negative caspase 8 , dominant negative Fas associated death domain , CrmA ( receptor pathway ) , or Bcl 2 or Bcl 10 ( L ) ( mitochondrial pathway ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The change in the expression of Bcl 2 , Bcl 10 ( L ) , and Bax in response to hop bitter acids was studied , and the Bcl 2 protein level slightly decreased ; however , the Bcl 10 ( L ) protein level was obviously decreased , whereas the Bax protein level was dramatically increased , indicating that the control of Bcl 2 family proteins by hop bitter acids might participate in the disruption of mitochondrial integrity . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
METHODS : We screened Bcl w , Bcl 10 , and Bax ( members of Bcl 2 family ) using polymerase chain reaction and singlestrand conformation polymorphism analysis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Of the apoptotic mediators tested , the anti apoptotic protein Bcl 10 ( L ) was strongly down regulated by combined treatment of the cells with SBHA and TRAIL but not by the HDAC inhibitor alone , while little or no change in the expression of other Bcl 2 family members highly expressed in MM cells , including Mcl 1 and Bax , was observed . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 family members ( Bcl 2 , Bax , Bcl w and Bcl 10 ( L ) ) are crucial integrators of signals for cell survival and death ; the pro or antiapoptotic activities of these proteins are regulated by their subcellular localization . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Here , we showed a marked neurite extension in MN9D dopaminergic neuronal cells overexpressing Bcl 2 ( MN9D / Bcl 2 ) or Bcl 10 ( L ) ( MN9D / Bcl 10 ( L ) ) . ^^^ We found a specific increase in phosphorylation of c Jun N terminal kinase ( JNK ) accompanied by neurite extension in MN9D / Bcl 2 but not in MN9D / Bcl 10 ( L ) cells . ^^^ Consequently , neurite extension in MN9D / Bcl 2 but not in MN9D / Bcl 10 ( L ) cells was suppressed by treatment with SP 600125 , a specific inhibitor of JNK . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Immunoprecipitation indicated that P 4 could bind to Bcl 2 and Bcl 10 ( L ) , which are associated with mitochondria and regulate apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 and Bcl 10 ( L ) are pro survival members of the Bcl 2 family . ^^^ In addition , we discovered that transient expression of Bcl 2 , unlike its pro survival homolog Bcl 10 ( L ) , can lead to the release of cytochrome c from mitochondria and that the resulting cell death can be inhibited by caspase and calpain inhibitors . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
When cells were co transfected with the GFP gene and the bcl 2 family genes bcl 2 , bcl 10 ( L ) , and bax , mitochondria appeared to aggregate at the periphery of the nucleus specifically where GFP was expressed . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Consistent with resveratrol ' s ability to kill cells via nonapoptotic processes , cells transfected to express high levels of the antiapoptotic proteins Bcl 10 ( L ) and Bcl 2 are equally sensitive as control cells to resveratrol . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
OBJECTIVE : This study investigated the expression of cellular apoptosis susceptibility protein ( CAS ) in serous ovarian carcinoma by immunohistochemistry and compared it with topoisomerase IIalpha ( topo IIalpha ) , bcl 2 , bcl 10 , the frequency of apoptotic bodies ( ABI ) , mitotic activity , and c erbB 2 with regard to clinicopathologic variables . ^^^ METHODS : Formalin fixed , paraffin embedded archival tissue sections of 10 benign serous cystadenomas , 10 serous neoplasms of low malignant potential ( LMP ) , and 41 serous ovarian carcinomas were immunostained with antibodies to CAS , bcl 10 , topo IIalpha , bcl 2 , and c erbB 2 . ^^^ Immunostaining for CAS , bcl 10 , and bcl 2 was scored concerning approximate percentage of positive tumor cells and relative staining intensity . ^^^ CAS immunoreactivity was positively related with ABI ( P = 0 . 0170 ) , mitotic activity ( P < 0 . 0001 ) , c erbB 2 ( P = 0 . 0153 ) , grade ( P = 0 . 0107 ) , and adverse outcome ( P = 0 . 0035 ) , but not with FIGO stage , topo IIalpha , bcl 2 , and bcl 10 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
These results came along with a low level of the anti apoptotic proteins Bcl 2 and Bclx ( L ) in Wmyo , whereas there was an increase in the level of the pro apoptotic molecule Bax when compared to the results obtained for Fb and Hmyo . ^^^ Hmyo showed a higher level of Bcl 2 compared to Fb but no difference in the Bax or Bclx ( L ) level . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 10 ( L ) showed a trend for increased expression in Bcl 2 FL as compared with Bcl 2+ FL , although the differences did not reach statistical significance ( P > 0 . 1 ) . ^^^ The increase in Bcl 10 ( L ) may provide an alternative antiapoptotic signal in FL negative for Bcl 2 protein . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
This occurs through complexation of the DNA binding region of p 53 with the anti apoptotic proteins Bcl 10 ( L ) and Bcl 2 ( Mihara , M . et al . ( 2003 ) Mol . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We assessed survivin expression in ovarian carcinoma , correlating results with expression of other anti apoptotic ( bcl 2 , bcl 10 , mutant p 53 ) and pro apoptotic ( bax ) markers , with prognostic parameters , and prognosis . ^^^ Paraffin embedded sections of 49 ovarian carcinoma were immunostained for survivin , bcl 2 , bcl 10 , bax , and p 53 . ^^^ Frequency of survivin , bcl 2 , bcl 10 , bax , and p 53 was 73 . 5 % , 36 . 7 % , 93 . 9 % , 77 . 6 % , and 60 . 4 % , respectively . ^^^ Survivin expression did not correlate with bcl 2 , bcl 10 , or bax expression , stage , or overall or disease free survival . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Instead , SNU 398 cells express high levels of the anti apoptotic Bcl 2 and Bcl 10 ( L ) proteins and the level of Bcl 10 ( L ) could be further induced upon paclitaxel treatment . ^^^ Therefore , these results strongly suggest that Bcl 2 and Bcl 10 ( L ) play an important role in mediating resistance to paclitaxel . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
This study evaluated whether chemoresistance associated with Bcl 2 and Bcl 10 ( L ) overexpression would be overcome by activating the death receptor pathway by tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) in the Jurkat cell model EXPERIMENTAL DESIGN : We made use of genetically modified Jurkat cells to evaluate the effect of Bcl 2 or Bcl 10 ( L ) overexpression on the cytotoxic effect produced by the anticancer drugs doxorubicin , etoposide , and oxaliplatin and TRAIL . ^^^ RESULTS : Bcl 2 and Bcl 10 ( L ) overexpression but not lack of caspase 8 protects the Jurkat cells from the anticancer drug induced cytolysis . ^^^ However , Bcl 2 / Bcl 10 ( L ) Jurkat cells retained some susceptibility to TRAIL induced cytolysis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Neutralization of endogenous BAFF and APRIL by soluble TACI and BCMA decoy receptors attenuates the survival of NHL B cells , decreases activation of the prosurvival transcription factor NF kappaB , down regulates the antiapoptotic proteins Bcl 2 and Bcl 10 ( L ) , and up regulates the proapoptotic protein Bax . ^^^ Conversely , exposure of NHL B cells to recombinant or myeloid cell derived BAFF and APRIL attenuates apoptosis , increases NF kappaB activation , up regulates Bcl 2 and Bcl 10 ( L ) , and down regulates Bax . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
No modifications of Bcl 2 , Bcl 10 , and Bax levels were observed , as well as no changes in Pi3K / Akt and JAK / STAT pathways that are often constitutively active in these cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Here , by using a combination of nuclear magnetic resonance binding assays , fluorescence polarization assay , and computational docking studies , we found that certain green tea catechins and black tea theaflavins are very potent inhibitors ( K ( 1 ) in the nanomolar range ) of the antiapoptotic Bcl 2 family proteins , Bcl 10 ( L ) and Bcl 2 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
RESULTS : Expression of Bcl 2 and Bcl 10 ( L ) in A2780 / DDP and COC1 / DDP cells was significantly higher than that in A 2780 and COC 1 cells , respectively . ^^^ CONCLUSION : We conclude that overexpression of antiapoptotic proteins Bcl 2 and Bcl 10 ( L ) and down regulation of caspase 3 activity may be associated with cisplatin resistance in human ovarian cancer . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
These events were associated with down regulation of antiapoptotic members of the Bcl 2 family , Bcl 2 and Bcl 10 ( L ) , and dephosphorylation of the serine / threonine protein kinase Akt . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Survivin , bcl 2 , bax , and bcl 10 gene expression in sentinel lymph nodes from melanoma patients . ^^^ PURPOSE : The expression of apoptosis related genes , such as survivin , bcl 2 , bcl 10 , and bax , has been evaluated by reverse transcriptase polymerase chain reaction ( RT PCR ) and by immunohistochemistry in sentinel lymph nodes ( SLNs ) from melanoma patients and then correlated to the outcome of patients . ^^^ After RNA extraction , an RT PCR followed by Southern blot hybridization was performed to detect survivin , bcl 2 , bcl 10 , and bax mRNA . bcl 2 , survivin , and bax gene expression was evaluated , whenever possible , also by immunohistochemistry at the protein level . ^^^ We did not find a significant correlation between bcl 2 , bax , and bcl 10 gene expression and outcome of patients . ^^^ CONCLUSION : Our findings show a variable expression of apoptosis related genes in SLNs of melanoma patients ; more interestingly , we found that survivin expression correlates to outcome of patients in a statistically significant way , whereas the expression of other genes , such as bcl 2 , bax , and bcl 10 , did not seem to correlate to progression of disease . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Expression of biomolecular markers ( Ki 67 , PCNA , Bcl 2 , BAX , BclX , VEGF ) in breast tumors . ^^^ We carried out a retrospective immunohistochemical study of Ki 67 , PCNA , Bcl 2 , BAX , BclX , and VEGF expression in tumors of two groups of breast cancer patients with favorable and unfavorable course of the disease . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The purpose of this study was to determine whether anti apoptotic proteins of the Bcl 2 family such as Bcl 2 and Bcl 10 ( L ) , proteins that confer resistance to apoptotic death from some stimuli , block apoptotic cell death in RAW264 . 7 cells upon treatment with Trichomonas vaginalis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Western blotting showed that 0 . 1 microM PAO downregulated the expression of both Bcl 2 and Bcl 10 ( L ) proteins , whereas 1 microM As2O3 downregulated only Bcl 2 expression . ^^^ PAO induced apoptosis seems to be related to the activation of the mitochondrial pathway and downregulation of both Bcl 2 and Bcl 10 ( L ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The apoptosis was associated with release of cytochrome c from the mitochondria and caspase activation , and was blocked by caspase inhibitors and the anti apoptotic proteins Bcl 2 , and Bcl 10 ( L ) , suggesting a role for mitochondrial pore formation . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Firstly , we found that VPA induced apoptosis in two of the four human melanoma cell lines , while both TSA and SAHA exhibited an antiproliferative and apoptotic effects in all four cell lines , a different expression of Bcl 2 and BclX ( L / S ) occurred . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The preliminary estimation of bcl 2 , bcl 10 ( L ) and p 53 genes expression in locally advanced non small cell lung cancer . ^^^ Our paper presents preliminary estimation of expression of protooncogenes : bcl 2 and bcl 10 ( L ) as well as of p 53 suppressor gene in ( NSCLC ) non small cell lung cancer patients . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Data are described on a retrospective immunohistochemical study of the Ki 67 , PCNA , Bcl 2 , BAX , BclX and VEGF expression in tumors of two groups of patients with breast cancer ( BC ) and with the favorable and unfavorable clinical courses . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Alterations in the cellular distribution of bcl 2 , bcl 10 and bax in the adult rat substantia nigra following striatal 6 hydroxydopamine lesions . ^^^ In this study we examined the localization of the pro apoptotic protein bax , and the anti apoptotic proteins bcl 2 and bcl 10 ( L ) in the substantia nigra ( SN ) of the adult rat and their response to oxidative stress caused by striatal injections of 6 hydroxydopamine ( 6 OHDA ) . ^^^ Our data show that bcl 2 , bcl 10 and bax proteins are present in the SN . ^^^ Bcl 10 staining in neurons was weak , though it was strongly expressed in GFAP positive astrocytes . 6 OHDA injections , which resulted in loss of dopamine neurons between 7 14 days post lesion , altered the distribution of bax , bcl 2 and bcl 10 proteins in the SN . ^^^ While the neuronal distribution of bcl 2 and bcl 10 does not change following lesion , bax became evenly distributed thought the soma . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In addition , release of cytochrome c from mitochondria , down expression of Bcl 2 and Bcl 10 ( L ) , up regulation of Bax , and caspase 9 activities were observed in SM treated A 549 cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Consistent with these findings , apoptosis induced by phenylurea based compounds was not altered by genetic alterations in the expression of Bcl 2 family proteins that control mitochondria dependent cell death pathways , including over expression of anti apoptotic proteins Bcl 2 or Bcl 10 ( L ) and genetic ablation of pro apoptotic proteins Bax and Bak . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Coadministration of TRAIL markedly increased FP induced apoptosis in leukemic cells ectopically expressing Bcl 2 , Bcl 10 ( L ) , or a phosphorylation loop deleted form of Bcl 2 ( DeltaBcl 2 ) , whereas lethality was substantially attenuated in cells ectopically expressing CrmA , dominant negative FADD , or dominant negative caspase 8 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Here , we found that shikonin induced apoptotic cell death was accompanied by upregulation of p 27 , p 53 , and Bad and down regulation of Bcl 2 and Bcl 10 ( L ) , while shikonin had little effect on the levels of Bax protein . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The pro apoptotic protein Fas , FasL , Bax and the anti apoptotic protein Bcl 2 , Bcl 10 ( L ) , Bcl 2 alpha were studied immunohistochemically by SP method . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The purpose of this study was to determine whether NF kappaB was constitutively activated in human colorectal tumor tissues and , if so , to determine the role of NF kappaB in colorectal tumorigenesis , and furthermore , to determine the association of RelA expression with tumor cell apoptosis and the expression of Bcl 2 and Bcl 10 ( L ) . ^^^ METHODS : Paraffin sections of normal epithelial , adenomatous and adenocarcinoma tissues were analysed immunohistochemically for expression of RelA , Bcl 2 and Bcl 10 ( L ) proteins . ^^^ The mRNA expressions of Bcl 2 and Bcl 10 ( L ) were determined by reverse transcription polymerase chain reaction ( RT PCR ) analysis . ^^^ Meanwhile , the expressions of Bcl 2 and Bcl 10 ( L ) protein and their mRNAs were significantly higher in adenocarcinoma tissues than that in adenomatous and normal epithelial tissues . ^^^ CONCLUSION : NF kappaB may inhibit apoptosis via enhancing the expression of the apoptosis genes Bcl 2 and Bcl 10 ( L ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Moreover , we found that the TG 2 BH3 peptides as well as TG 2 itself were able to interact with the pro apoptotic Bcl 2 family member Bax , but not with anti apoptotic members Bcl 2 and Bcl 10 ( L ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The apoptotic pathway triggered by the Fhit protein in lung cancer cell lines is not affected by Bcl 2 or Bcl 10 ( L ) overexpression . ^^^ Infection of these cells with an adenoviral vector transducing the Fhit gene ( Ad Fhit ) revealed that complete protection from apoptosis was conferred by the inhibitor of caspases Cytokine response modifier A ( CrmA ) and by a dominant negative form of the adapter protein Fas associated death domain ( FADD ) and partial protection by a dominant negative form of caspase 8 , while cells over expressing mitochondrial mediators of the apoptotic response such as Bcl 2 or Bcl 10 ( L ) that are resistant to treatment with cisplatin , remained highly susceptible to cell death triggered by Fhit gene transfer . ^^^ Analysis of cytochrome c release also confirmed that in Bcl 2 or Bcl 10 ( L ) expressing cells apoptosis could be detected by terminal deoxynucleotidyl transferase mediated dUTP nick end labelling ( TUNEL ) assay before any evidence of mitochondrial membrane perturbation . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In particular , it has been shown that PECAM 1 binds to different kinases and phosphatases , including the phosphatidylinositide 3 kinase that phosphorylates Akt , which , in turn can upregulate transcription and function of antiapoptotic proteins , such as Bcl 2 and Bcl 10 or A 1 , responsible for the rescue from mitochondrial apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In the present paper , we demonstrate that the absence of apoptosis in HIV 1 infected primary human monocyte differentiated macrophages ( MDM ) correlates with an increase in anti apoptotic ( Bcl 2 and Bcl 10 ( L ) ) and a decrease in pro apoptotic ( Bax and Bad ) proteins . ^^^ TNF production was shown to be involved in the upregulation of Bcl 2 and Bcl 10 ( L ) because this increase was abolished by an anti TNF anti serum or an inhibitor of TNF synthesis . ^^^ Furthermore , using an inhibitor of NF kappaB activation , we demonstrated that TNF induced upregulation of Bcl 10 ( L ) and Bcl 2 occurs , respectively , through a NF kappaB dependent and an NF kappaB independent pathway . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Some members of this family , notably Bcl 2 and Bcl 10 ( L ) , are overexpressed in cancer cells , which have been associated with chemoresistance . ^^^ This inhibitor induces apoptosis of hematopoietic progenitors overexpressing Bcl 2 but not Bcl 10 ( L ) and breast cancer cells that express high levels of Bcl 2 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Our results demonstrated that 16 genes ; bad , bax , bcl 2 , bcl w , bcl 10 , caspase 3 , caspase 7 , caspase 8 , c myc , E 124 , GADD 45 , mdm 2 , NKkappab 1 , p 53 , p 21 , Rb and trail were up regulated and six genes ; caspase 1 , caspase 2 , DR 5 , E2F1 , FasL and iNOS did not changed in response to DES treatment in wild type mice compared to p53+ / knockout mice . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Furthermore , TAS 106 was shown to decrease the radiation induced expression of survivin but not Bcl 2 and BclX ( L ) regardless of TP 53 status and cell type . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Overexpression of Bcl 2 or Bcl 10 ( L ) , loss of Bax or Bak function , high expression of inhibitor of apoptosis proteins , and reduced release of second mitochondria derived activator of caspases ( Smac / Diablo ) from the mitochondria to the cytosol have all been reported to result in TRAIL resistance in mitochondria dependent type 2 cancer cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
AIM : To observe the relationship between apoptosis of mouse thymic lymphocytes and the expressions of bax , bcl 2 and bcl 10 ( L ) after gamma ray radiation with lethal dose and provide the basis for treatment of acute severe radiation sickness . ^^^ The expressions of bax , bcl 2 and bcl 10 ( L ) were detected by in situ hybridization and immunohistochemical staining . ^^^ On the other hand , the expressions of Bcl 2 and Bcl 10 ( L ) proteins reduced evidently at 3 h after radiation , reaching the lowest level at 24 h . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Western blotting was used to assess activation of caspases 3 , 9 , anti poly ( ADP ribose ) polymerase , p 53 , p 21 , AIF , IkappaBalpha , Bcl 2 , Bcl 10 ( L ) , and cyclin D 1 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
This non apoptotic death of double knockout cells was suppressed by inhibitors of autophagy , including 3 methyl adenine , was dependent on autophagic proteins APG 5 and Beclin 1 ( capable of binding to Bcl 2 / Bcl 10 ( L ) ) , and was also modulated by Bcl 10 ( L ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
However , anti apoptotic Bcl 2 and Bcl 10 ( L ) were elevated and the cell cycle regulator cyclin D 1 was slightly upregulated with both 1 and 5 microM cisplatin treatment . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The impaired phosphorylation of p 65 and the reduced nuclear translocation of NF kappaB proteins were associated with down regulation of the constitutively overexpressed and NF kappaB dependent antiapoptotic proteins Bcl 2 and Bcl 10 ( L ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
An up regulated expression of Bcl 2 and Bcl 10 ( L ) proteins was observed in ECSC in comparison with ESCwE and NESC , whereas the levels of Bax , Bad , Fas and Fas ligand proteins in ECSC were similar to those in ESCwE and NESC . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Finally , gefitinib suppressed the expression of antiapoptotic Bcl 2 and Bcl 10 ( L ) , further rendering HCC cells prone to apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The number of positive cell for CD 3 , CD 4 , CD 8 , CD 25 , CD 28 , CTLA 4 ( CD 152 ) , Fas , FasL , bcl 2 , bcl 10 were determined using immunohistochemical staining techniques . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Antiapoptotic molecules such as Bcl 2 and Bcl 10 ( L ) are often overexpressed in cancer cells and their inhibition is an attractive target for selective killing of tumor cells via induction of apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The major antiapoptotic family members , Bcl 10 ( L ) and Bcl 2 , and the major proapoptotic proteins , Bax and Bak , show distinct temporal and spatial patterns of expression in the developing brain . ^^^ Targeted deletions of Bcl 10 ( L ) and Bcl 2 as well as Bax and Bak have proven to be important tools in delineating the process of cell death in the nervous system . ^^^ Bax , Bcl 10 ( L ) , and Bcl 2 regulate the apoptotic response to neurotrophic factor deprivation . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The enhanced survival , and thus clonal expansion , supported by IL 12 is not due to increased Bcl 2 or Bcl 10 ( L ) expression ; both are maximally activated by signals 1 and 2 . ^^^ The time courses of expression suggest that Bcl 2 and Bcl 10 ( L ) promote survival early in the response , whereas Bcl 3 acts later in the response . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Here we showed that , besides the specific cleavage and activation of Bid by caspase 8 and caspase 3 , TRAIL induced apoptosis in Jurkat T cells required the specific cleavage of Mcl 1 at Asp 127 and Asp 157 by caspase 3 , while other prototypic antiapoptotic factors such as Bcl 2 or Bcl 10 ( L ) seemed not to be affected . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Apoptosis was assessed in various types of gliomas and was defined by the apoptotic index ( IA ) and shown immunohistochemically with using Bcl 2 , Bax and Bcl 10 antibodies . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Here we show that ligation of hOSCAR by specific antibodies promotes dendritic cell ( DC ) survival by an extracellular signal regulated kinase ( ERK ) and phosphatidylinositol 3 kinase ( PI3K ) dependent pathway , linked to expression of the Bcl 2 and Bcl 10 ( L ) antiapoptotic molecules . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Inhibition of apoptosis closely correlated with sequestration of Bax , Bid and BAD in the mitochondrial inner membrane , increased Bcl 2 and Bcl 10 ( L ) , and inability to process p 21 Bid . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Preclinical studies of a nonpeptidic small molecule inhibitor of Bcl 2 and Bcl 10 ( L ) [ ( ) gossypol ] against diffuse large cell lymphoma . ^^^ Overexpression of Bcl 2 / Bcl 10 ( L ) protein has been observed in more than 80 % of B cell lymphomas . ^^^ Diffuse large cell lymphoma ( DLCL ) is the most common subtype of non Hodgkin ' s lymphoma . ( ) Gossypol , a natural product isolated from cottonseeds , was discovered as a potent small molecule inhibitor of Bcl 2 and Bcl 10 ( L ) proteins , with a Ki value in the nanomole per liter range for both . ^^^ As expected ( ) gossypol induced complete cytochrome c release from mitochondria , increased caspases 3 and 9 activity , and caused apoptotic death without affecting protein levels of Bcl 2 , Bcl 10 ( L ) , Bax , and Bak . ^^^ We conclude that adding Bcl 2 / Bcl 10 ( L ) small molecule inhibitor to standard chemotherapy may prove an effective strategy in lymphoma therapy . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Gossypol acts directly on the mitochondria to overcome Bcl 2 and Bcl 10 ( L ) mediated apoptosis resistance . ^^^ Aberrant overexpression of antiapoptotic members of the Bcl 2 protein family , including Bcl 2 and Bcl 10 ( L ) , contributes to malignant transformation and subsequent resistance to traditional chemotherapeutics . ^^^ Recently gossypol has been found to bind to Bcl 10 ( L ) and , with less affinity , to Bcl 2 . ^^^ Here we investigate the ability of the ( ) enantiomer of gossypol , ( ) gossypol , to overcome the apoptosis resistance conferred by Bcl 2 or Bcl 10 ( L ) overexpression in Jurkat T leukemia cells . ( ) Gossypol potently induced cell death in Jurkat cells overexpressing Bcl 2 ( IC 50 , 18 . 1+ / 2 . 6 micromol / L ) or Bcl 10 ( L ) ( IC 50 , 22 . 9+ / 3 . 7 micromol / L ) . ^^^ Additionally , ( ) gossypol was more efficient than etoposide at inducing caspase 3 activation and phosphatidylserine externalization in the setting of Bcl 2 or Bcl 10 ( L ) overexpression . ( ) Gossypol induced apoptosis was associated with Bak activation and release of cytochrome c from mitochondria , suggesting a mitochondrial mediated apoptotic mechanism . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Our results also show that Bcl 2 , Bcl 10 ( L ) and Bax protein levels and heterodimerization are selectively regulated by NMDA and non NMDA receptor stimulation . ^^^ In contrast , changes in Bax protein levels are not required for KA induced apoptotic cell death , but decreased levels of both Bax : Bcl 2 and Bax : Bcl 10 ( L ) heterodimer levels are necessary . ^^^ Intrastriatal grafting of a BDNF secreting cell line counter regulated p AKT , Bcl 2 , Bcl 10 ( L ) and Bax protein levels , prevented changes in the heterodimerization between Bax and pro survival proteins , and blocked caspase 3 activation induced by excitotoxicity . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The expression of regulating molecules was analyzed by Western blotting for p 53 , p 21 ( WAF1 / CIP1 ) , and the Bcl 2 family , such as Bcl 2 , Bax , and Bcl 10 ( L / s ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We hypothesized that expression of Bcl 10 ( L ) , a homologue of Bcl 2 that confers protection from chemotherapy induced apoptosis , may be predictive of patients ' clinical response to treatment , and that treatment with chemotherapy may result in the selection of tumor cells that overexpress this protein . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
This hypothesis was tested in CD 20 ( + ) drug resistant Ramos ( Bcl 2 ( ) / Bcl 10 ( L ) ( + ) ) and Daudi ( Bcl 2 ( + ) / Bcl 10 ( L ) ( + ) ) cell lines . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Fucoxanthin treatment caused cleavages of procaspase 3 and poly ( ADP ribose ) polymerase without any effect on the protein level of Bcl 2 , Bcl 10 ( L ) , or Bax . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The Bcl 2 family protein Bcl 10 ( L ) suppressed cytochrome c release as well as processing of procaspases 3 , 8 , and 9 in E 73 treated cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Apoptosis was assessed by DNA laddering , localizing apoptotic bodies using immunofluorescent labeling of DNA fragments ( the terminal deoxynucleotidyl transferase mediated dUTP nick end labeling method ) , and immunohistochemical assessment of apoptosis markers bcl 2 , bcl 10 , and bax . ^^^ Immunostaining for bcl 2 was higher in hCG and progesterone treated cycles , whereas bax expression was decreased and bcl 10 immunostaining was not different between treatments . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Neither t ( 11 ; 18 ) ( q 21 ; q 21 ) , nor t ( 1 ; 14 ) ( p 22 ; q 32 ) or any other translocation involving IGH , BCL 10 , MALT 1 , BCL 2 and API 2 , amplification or deletion of chromosomal region 11q21 , 18q21 , 1p22 , and 14q32 was detected . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Antiapoptotic ( Bcl 2 and Bcl 10 ( L ) ) and proapoptotic ( Bax and Bad ) proteins were expressed in neonatal rat hearts of both groups . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Specifically , we observe that Abeta significantly reduces expression of antiapoptotic Bcl w and Bcl 10 ( L ) , mildly affects expression of bim , Bcl 2 , and bax , but does not alter expression of bak , bad , bik , bid , or BNIP3 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Expression of c FLIP , Fas associated phosphatase 1 , FADD , Bcl 2 , Bcl 10 ( L ) , and Bcl 10 ( S ) was determined by Western blot analysis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
RESULTS : Overexpression of the apoptosis inhibitors Bcl 2 and Bcl 10 ( L ) was observed in 10 of 41 samples ( 24 % ) and in 11 of 41 samples ( 27 % ) , respectively . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Under these conditions , SNAP was able to oppose cell death through both caspase 3 inhibition and / or increase of antiapoptotic protein levels ( Bcl 2 and Bcl 10 ( L ) ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Different protein regulators of apoptosis , such as Bcl 2 , BclX , and Bax have an influence on the rate of apoptosis in various tumors . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 10 ( L ) , an antiapoptotic member of the Bcl 2 family that does not affect ER Ca ( 2+ ) uptake , supports neuronal survival but can not activate CREB and Erk or promote axon regeneration . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In the current study , we demonstrated that in normal tonsil B cells the three major Bim isoforms are strongly associated with the anti apoptotic Bcl 2 family members Mcl 1 , Bcl 2 and Bcl 10 ( L ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Glutamate excitotoxicity decreased bcl 2 , bcl 10 ( L ) , and bax mRNA levels , . ^^^ NMDA increases Bcl 2 and Bcl 10 ( L ) protein levels and decreases Bax protein levels . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Previous reports have identified both Bcl 2 and Bcl 10 ( L ) proteins as survival factors in lung cancer cells since reductions in these proteins can induce apoptosis and sensitize lung cancer cells to apoptosis induced by chemotherapy agents . ^^^ Lung cancer cells overexpressing Mcl 1 are less sensitive to apoptosis induced by chemotherapeutic agents , ZD 1839 ( an inhibitor of EGFR tyrosine kinase ) and Bcl 2 or Bcl 10 ( L ) antisense oligonucleotides . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
This combination induced monocytic differentiation of NB 4 acute promyelocytic leukemia ( APL ) cells and HL 60 AML cells and caused both to undergo apoptosis associated with down regulation of Bcl 2 and Bcl 10 ( L ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Downmodulation of the ERK1 / 2 and NF kappa B pathways inhibits the transcriptional activity of AP 1 and NF kappa B transcription factors , respectively , both of which lead to the downregulation of Bcl ( xL ) ( Bcl 2 related gene ( long alternatively spliced variant of Bcl 10 gene ) ) transcription and expression and sensitization to drug induced apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
RA repressed c fos mRNA expression in control and irradiated SiHa cultures , but did not repress bcl 10 ( L ) , p 53 , GADD 45 , p 21 , bax , bcl 2 , or mcl 1 mRNA expression . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Prevalence of apoptosis was defined by TUNEL and ISOL staining and further characterized by immunohistochemical staining for caspase 3 , Bcl 2 , BCL 10 ( L ) , Bax , proliferating cell nuclear antigen ( PCNA ) , and Ki 67 . ^^^ The antiapoptotic proteins , Bcl 2 and BCL 10 ( L ) , demonstrated intense upregulation within and surrounding MFL cells , whereas pro apoptotic protein Bax expression was only seen at control level . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Chromatin immunoprecipitation assay employing anti Stat 3 antibody confirms the in vivo binding of activated Stat 3 to the promoters of genes that encode antiapoptotic proteins Bcl 2 , Bcl 10 ( L ) , and Mcl 1 . ^^^ IL 4 significantly up regulates of the steady state levels of Bcl 2 , Bcl 10 ( L ) , and Mcl 1 in GBM cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Colonic CD 4 + T cells with high expressions of antiapoptotic Bcl 10 and Bcl 2 were found to use selected subsets ( 5 beta 14 ) of T cell receptor and to exclusively produce IL 6 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bax , bcl 2 and bcl 10 change their expression in stromal cells , whereas bcl 10 was induced after drug treatment and bcl 2 down regulated in progenitor cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
These apoptotic pathways are likely regulated by the concurrent expression of prosurvival molecules , including Bcl 2 and Bcl 10 ( L ) ; phosphorylation of Bad ; and high expression of inhibitor of apoptosis proteins chicken IAP 1 , IAP 3 , and survivin . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We explored effects of oridonin on antiapoptotic Bcl 2 family members and found that it down regulated levels of Mcl 1 and BCL 10 ( L ) , but not Bcl 2 protein , in both MT 1 and RPMI 8226 cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
A number of proteins mediated with apoptotic process have been identified , including p 53 , BAX , BCL 2 and BCL 10 . ^^^ In the cultures exposed to pure anoxia , a significant increase of p 53 and BAX immunoreactivity , associated with the decreased level of BCL 2 and BCL 10 immunopositive cells was observed , related to the activation of apoptotic process . ^^^ This strong immunoreactivity of proapototic proteins ( p 53 and BAX ) in hippocampal cultures exposed to anoxia or / and TPEN correlated with previous ultrastructural evidences of anoxia and TPEN induced apoptosis , while the overexpression of anti apoptotic protein ( BCL 2 and BCL 10 ) in zinc pretreated cultures evidenced the protective ability of this metal against apoptosis in model of anoxia in vitro . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
RESULTS : Multiple survival factor genes , including cellular inhibitor of apoptosis protein ( c IAP 1 ) , c IAP 2 , TNF receptor associated factor 1 ( TRAF 1 ) , TRAF 2 , B cell leukemia / lymphoma 2 ( Bcl 2 ) , Bcl 10 , A 1 , and cellular Fas associated death domain ( FADD ) like interleukin 1beta converting enzyme like inhibitory protein ( c FLIP ) , were expressed in basal conditions in both cultured RPE cells and RPE cells in situ , whereas survivin was expressed only by cultured cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
RESULTS : High expression of Mcl 1 was seen in the Karpas 299 cell line , whereas the two other antiapoptotic Bcl 2 family members , Bcl 2 and Bcl 10 ( L ) , were not detected in the SAGE library . ^^^ Quantitative RT PCR confirmed the high expression of Mcl 1 mRNA and low expression of Bcl 2 and Bcl 10 ( L ) in Karpas 299 and in four other ALCL cell lines . ^^^ To expand on these initial observations , primary tissue samples were analysed for Mcl 1 , Bcl 10 ( L ) , and Bcl 2 by immunohistochemistry . ^^^ Bcl 2 and Bcl 10 ( L ) were expressed infrequently in ALK+ ALCL cases , but were present in a higher proportion of ALK ALCL cases . ^^^ The high frequency of Mcl 1 , Bcl 2 , and Bcl 10 ( L ) positive ALCL cases in the ALK group compared with the ALK+ group indicates that ALK induced STAT 3 activation is not the main regulatory pathway in ALCL . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 10 ( S ) , a proapoptotic member of the Bcl 2 protein family , is localized in the mitochondria and induces apoptosis in a caspase and BH 3 dependent manner by a mechanism involving cytochrome c release . ^^^ The way in which Bcl 10 ( S ) induces caspase activation and cytochrome c release , as well as the relationship between Bcl 10 ( S ) and other proapoptotic members of the Bcl 2 family , is not known . ^^^ Here we used embryonic fibroblasts derived from mice deficient in the multidomain proapoptotic members of the Bcl 2 family ( Bax and Bak ) and the apoptotic components of the apoptosome ( Apaf 1 and caspase 9 ) to unravel the cascade of events by which Bcl 10 ( S ) promotes apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The proapoptotic response was associated with down regulation of Bcl 2 and Bcl 10 ( L ) expression and induction of cleavage of caspase 3 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
It is of note that in NK cells from patients with early HIV 1 infection , mRNA expression of Bcl 2 and Bcl 10 ( L ) was consistently lower than that in healthy donors ; interestingly , TGF beta and Tat were detected in the sera of these patients . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The expression of apoptosis related genes was assessed by RT PCR and bcl 2 mRNA was found to decrease after exposure to ceramide while Bcl 10 mRNA increased 12 h post treatment . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Both caused apoptosis by increasing the protein expression of Bax and Bcl xs while decreasing Bcl 2 and Bcl 10 ( L ) , releasing apoptogenic cytochrome c , and augmenting the activity of caspase 9 and caspase 3 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
These genes encode a host of proteins with divergent functions in a variety of cellular processes including apoptosis ( FAS , Fas ligand , PIN , HSP90beta , bcl 2 , bcl 10 ) , cell signal transduction ( Ras , RGS 1 , IRF 1 , STAT 3 ) , receptor mediated signaling transduction ( CD 71 , CD 69 , CD3delta ) , cell cycle and growth ( c myc , cytokines , kinase ) , transcriptional regulation ( EWS , CREB 2 ) , and chemotaxis ( beta chemokines , RANTES ) , supporting the general effects of HIV 1 infection on cells of different origin . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In these models , both SAHA and m carboxycinnamic acid bis hydroxamide induced growth arrest and caspase mediated apoptosis and increased p 21 protein levels , retinoblastoma hypophosphorylation , BH 3 interacting domain death agonist cleavage , Bax up regulation , down regulation of Bcl 2 , A 1 , and Bcl 10 ( L ) expression , and cleavage of poly ( ADP ribose ) polymerase and caspase 8 , 9 , 3 , 7 , and 2 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Several connections were demonstrated between Cox and a few oncogenes ( 5 src , 5 Ha ras , HER 2 \ neu , Wnt , p 53 mutated ) , alimentary products ( PUFAs ) , transcription factors ( c jun and c fos ) , proapoptotic proteins [ Bax et Bcl 10 ( L ) ] or antiapoptotic ( Bcl 2 ) , CYP 19 aromatase gene , NFkappaB receptor ( RANKL ) , angiogenesis ( via VEGF , TXA 2 , oxid nitric synthetase , alphaVbeta 3 integrin receptor ) , peroxisome gamma proliferator receptor ( PPARgamma ) and its ligand PGJ 2 and with antitubuline chemotherapy drugs . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We have investigated the regulation of Bak and find that , in healthy cells , Bak associates with Mcl 1 and Bcl 10 ( L ) but surprisingly not Bcl 2 , Bcl w , or A 1 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Proteins in the Bcl 2 family are central regulators of programmed cell death , and members that inhibit apoptosis , such as Bcl 10 ( L ) and Bcl 2 , are overexpressed in many cancers and contribute to tumour initiation , progression and resistance to therapy . ^^^ Bcl 10 ( L ) expression correlates with chemo resistance of tumour cell lines , and reductions in Bcl 2 increase sensitivity to anticancer drugs and enhance in vivo survival . ^^^ Here , using nuclear magnetic resonance ( NMR ) based screening , parallel synthesis and structure based design , we have discovered ABT 737 , a small molecule inhibitor of the anti apoptotic proteins Bcl 2 , Bcl 10 ( L ) and Bcl w , with an affinity two to three orders of magnitude more potent than previously reported compounds . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Consistent with the antiapoptotic effect of leptin , we observed the activation of NF kappaB and a parallel up regulation of bcl 2 and bcl 10 ( L ) gene expression . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Consequently , ACA suppressed the expression of TNF induced NF kappaB regulated proliferative ( e . g . , cyclin D 1 and c Myc ) , antiapoptotic ( survivin , inhibitor of apoptosis protein 1 ( IAP 1 ) , IAP 2 , 10 chromosome linked IAP , Bcl 2 , Bcl 10 ( L ) , Bfl 1 / A1 , and FLIP ) , and metastatic ( cyclooxygenase 2 , ICAM 1 , vascular endothelial growth factor , and matrix metalloprotease 9 ) gene products . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
PUMA , a key mediator of p 53 induced apoptosis , is a BH 3 only domain proapoptotic protein that localizes to mitochondria and interacts with antiapoptotic Bcl 2 and Bcl 10 ( L ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We have earlier reported that the inhibition of apoptosis in head and neck squamous cell carcinomas ( HNSCC ) is because of upregulated expression of Bcl 2 , Bcl 10 ( L ) and Survivin . ^^^ Treatment of HeP 2 and Cal 27 cells with 400 nM antisense oligonucleotides against Bcl 2 , Bcl 10 ( L ) and Survivin for 48 hrs decreased their expression both at the mRNA as well as at the protein level , resulting in the induction of apoptosis . ^^^ Our findings emphasize the importance of Bcl 2 , Bcl 10 ( L ) and Survivin as survival factors in HNSCC cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Activated STAT 3 leads to the induction of several genes such as Mcl 1 , Bcl 2 and Bcl 10 ( L ) , and tissue inhibitor of metalloproteinase ( TIMP ) 1 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Using immunohistochemistry the groups were compared for expression of apoptotic proteins : bcl 2 , bcl 10 ( L ) , bax , bak and survivin . ^^^ Radioresistant laryngeal cancer was associated with bcl 2 ( P < 0 . 001 ) and bcl 10 ( L ) ( P = 0 . 005 ) expression and loss of bax expression ( P = 0 . 012 ) in pretreatment biopsies . ^^^ The association between expression of bcl 2 , bcl 10 ( L ) and bax with radioresistant cancer suggests a potential mechanism by which cancer cells avoid the destructive effects of radiotherapy . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Axotomy caused a decrease in Bcl 2 and a small increase in Bcl 10 ( L ) . ^^^ FGF 2 treatment caused an ERK dependent increase in Bcl 2 and an ERK independent increase in Bcl 10 ( L ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
EPO facilitated neuritogenesis was paralleled by upregulation of Bcl 10 ( L ) , a Bcl 2 homologue capable of promoting RGC regeneration . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
CD4+ T lymphocyte and splenocyte counts were also reduced following 1 , 25 dihydroxyvitamin D 3 treatment and a marked induction of apoptosis , accompanied with down regulation of the anti apoptotic proteins Bcl 2 and Bcl 10 ( L ) , was observed . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The present study examined the effects of progesterone on mRNA and protein levels of the Bcl 2 apoptosis regulatory genes , bax , bad , bcl 2 , and bcl 10 ( L ) , in cerebral cortex after TBI . ^^^ Our results indicate that bax and bad mRNA levels and Bax and Bad protein expression in the ipsilateral , injured cerebral cortex were significantly elevated post TBI , while mRNA levels of bcl 2 and bcl 10 ( L ) or Bcl 2 and Bcl 10 ( L ) protein expression were not changed . ^^^ In addition , bcl 2 and bcl 10 ( L ) mRNA levels , as well as Bcl 2 and Bcl 10 ( L ) protein expression , were increased by progesterone in TBI injured cortex . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Distinct mechanisms of neuronal apoptosis are triggered by antagonism of Bcl 2 / Bcl 10 ( L ) versus induction of the BH 3 only protein Bim . ^^^ To determine if this is the principal function of Bim in CGNs , we contrasted Bim mediated apoptosis to neuronal death induced by HA 14 1 , a BH 3 domain mimetic that antagonizes Bcl 2 and Bcl 10 ( L ) . ^^^ Similarly , apoptosis induced by either a structurally distinct Bcl 2 / Bcl 10 ( L ) inhibitor ( compound 6 ) or Bcl 2 antisense oligonucleotides was diminished by glutathione . ^^^ These data show that antagonism of Bcl 2 / Bcl 10 ( L ) function elicits oxidative stress dependent CGN apoptosis that is mechanistically distinct from Bim mediated cell death . ^^^ These results further indicate that , although Bcl 2 / Bcl 10 ( L ) antagonism is sufficient to induce neuronal apoptosis , Bim likely promotes neuronal death by interacting with additional proteins besides Bcl 2 / Bcl 10 ( L ) . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
An important player in these pathways is Bcl 10 ( L ) , an antiapoptotic protein of the Bcl 2 family , which is neuroprotective in various in vitro and in vivo models of cell death . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Furthermore , Atiprimod inhibited signal transducer and activator of transcription ( STAT ) 3 activation , blocking the signalling pathway of interleukin 6 , which contributes to myeloma cell proliferation and survival , and downregulated the antiapoptotic proteins Bcl 2 , Bcl 10 ( L ) , and Mcl 1 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Immunoblot analysis for major antiapoptotic proteins showed considerable up regulation of the short form of cellular FLIP ( cFLIP ) and Bcl 10 ( L ) in BD activated T cells , while levels of Bcl 2 , caspase 3 , and caspase 8 in activated T cells from patients with BD were comparable with those in activated T cells from normal donors . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Further studies were conducted to compare these changes to the localization and expression of the bcl 2 group of proteins bcl 10 , bax and mcl 1 , and Fas Fas ligand in the same cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The concentrations of the pro apoptotic molecule caspase 3 was increased in transgenic animals whilst the concentrations of two pro survival molecules Bcl 2 and Bcl 10 were both decreased . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Apoptosis of T 24 cells by Chan Su was associated with a down regulation of anti apoptotic Bcl 2 and Bcl 10 ( S / L ) expression and an up regulation of pro apoptotic Bax expression . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Tregs had high susceptibility to apoptosis that was reversed by IL 2 , which correlated with activation of Erk1 / 2 , up regulation of Bcl 10 ( L ) ( B cell CLL / lymphoma 2 like nuclear gene encoding mitochondrial protein , transcript variant 2 ) , and phosphorylation of Bad ( Bcl 2 antagonist of cell death ) at Ser 112 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 10 ( L ) expression increased in the cisplatin resistant lines relative to the parental lines , whereas Bcl 2 expression was high in the parental lines and decreased in the cisplatin resistant lines . ^^^ We tested a small molecule BH 3 mimetic , ( ) gossypol , which binds to the BH 3 domain of Bcl 2 and Bcl 10 ( L ) , for activity against the parental and cisplatin resistant cell lines . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Intriguingly , and despite of interfering with a cellular machinery in charge of controlling the half life of the vast majority of cellular proteins , bortezomib did not promote a generalized disruption of melanoma associated survival factors ( including NF kappaB , Bcl 2 , Bcl 10 ( L ) , XIAP , TRAF 2 , or FLIP ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Therefore , this study investigated whether or not the expression of p 53 , the Fas / Fas ligand ( FasL ) , Bcl 2 / Bcl 10 ( L ) determines the enhanced drug susceptibility of SCK cells . ^^^ The results showed that Bcl 2 family molecules , such as Bid , Bak , and Bax , are involved in the parthenolide induced apoptosis and that the defective expression of Bcl 10 ( L ) might contribute to the higher parthenolide sensitivity in the SCK cells than in the other adenomatous cholangiocarcinoma cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The enhanced TRAIL effect after pretreatment with HDAC inhibitors was consistent with the upregulation of the proapoptotic Bcl 2 family members ( Bim , Bak , Bax , Noxa , and PUMA ) , the downregulation of the anti apoptotic members of the Bcl 2 family ( Bcl 2 and Bcl 10 ( L ) ) , and IAPs . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Trauma to the peripheral processes of sensory neurons of different subpopulations was followed by indirect immunohistochemical analysis of the expression of Bcl 10 ( L ) and Bax , which are , respectively , antiapoptotic and proapoptotic proteins of the Bcl 2 family , and also of the cytokine interleukin 1beta , with the aim of identifying the roles of these substances in controlling apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Moreover , sulforaphane induced apoptotic cell death was accompanied by upregulation of Bax and downregulation of Bcl 2 and Bcl 10 ( l ) protein . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Although the TLR 9 mediated death of Nfkb 1 ( / ) C Rel ( / ) pDCs , which coincided with a failure to up regulate the prosurvival proteins B cell lymphoma apoptosis regulator xL ( Bcl 10 ( L ) ) and A 1 , was blocked by Bcl 2 transgene expression , this inhibition of apoptosis still failed to rescue the differentiation defects . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
H CM activated nuclear factor kappaB ( NFkappaB ) protein and increased the gene expression of antiapoptotic factors including Bcl 2 , Bcl 10 ( L ) , survivin and 10 chromosome linked inhibitor of apoptosis protein ( XIAP ) in endothelial cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Moreover , the combination of secreted mda 7 / IL 24 and radiation engenders a ' bystander antitumor effect ' not only in inherently mda 7 / IL 24 or radiation sensitive cancer cells , but also in tumor cells overexpressing the antiapoptotic proteins bcl 2 or bcl 10 ( L ) and displaying resistance to either treatment alone . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Expression of Cdc2 / Cdk 1 , cyclin B 1 , cyclin A , p21 / Cip1 , pRb , pRb2 / p130 , Bcl 2 , Bcl 10 ( L ) , Bax and caspase 3 proteins were studied with western blot analysis . ^^^ Apoptosis markers like Bcl 2 and Bcl 10 ( L ) were significantly decreased and Bax and caspase 3 were increased . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In addition , antiapoptotic Bcl 2 and Bcl 10 ( L ) levels were increased and pro apoptotic Bax and Bak levels were decreased in the HIF 1alpha overexpressing OSCC line . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
BACKGROUND : Anti apoptotic Bcl 2 family proteins , such as Bcl 2 and Bcl 10 , can modulate radio and / or chemosensitivity of human malignancies . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Measures were mucosal apoptosis , proliferation , villous morphology , apoptotic , and proliferative mediators , such as Caspases 3 , 8 , Fas and Fas Ligand , Bcl 2 , and Bcl 10 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Pristimerin did not significantly alter the protein level of Bcl 2 family members ( Bcl 2 , Bcl 10 ( L ) , and Bax ) , nor did it induce Bax translocation . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
This was associated with up regulation of the pro death Bak and Bim , as well as with attenuation of the levels of Her 2 and XIAP , survivin , Bcl 2 , and Bcl 10 ( L ) proteins . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
METHODS : Twenty breast cancer patients who were categorized as pre and postmenopausal and 20 mammary gland tumors obtained from dogs were included in this study The expression of Bcl 2 , Bcl 10 ( L ) , Bax , caspases 8 and 3 as well as Hsp 70 and 90 in tumor tissues and adjacent tissues were investigated using Western blotting . ^^^ RESULTS : While expression of Bcl 2 , Bcl 10 ( L ) , Hsp 70 and 90 was increased , expression of Bax and caspases 8 and 3 was significantly lower in both human as well as canine mammary tumor tissues compared to corresponding adjacent tissues . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NPD 1 is synthesized in RPE cells undergoing oxidative stress , potently counteracts oxidative stress triggered apoptotic DNA damage in RPE , upregulates antiapoptotic proteins Bcl 2 and Bcl 10 ( L ) , and decreases proapoptotic Bax and Bad expression . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
It is likely that these signaling pathways control the level of pro and anti apoptotic proteins , yet assessment of Bcl 2 and Bcl 10 showed dramatic reduction in level only when large numbers of cells were dead suggesting this may be a consequence rather than cause of death . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
LAQ 824 induced lethality in U 937 cells did not involve the extrinsic apoptotic pathway , nor was it associated with death receptor up regulation ; instead , it was markedly inhibited by ectopic expression of Bcl 2 , Bcl 10 ( L ) , XIAP , and Mcl 1 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Immunoblot analysis revealed that PFE treatment of PC 3 cells resulted in ( 1 ) induction of Bax and Bak ( proapoptotic ) ; ( 2 ) down regulation of Bcl 10 ( L ) and Bcl 2 ( antiapoptotic ) ; ( 3 ) induction of WAF1 / p21 and KIP1 / p27 ; ( 4 ) a decrease in cyclins D 1 , D 2 , and E ; and ( 5 ) a decrease in cyclin dependent kinase ( cdk ) 2 , cdk 4 , and cdk 6 expression . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The blockade of JAK3 / STAT3 signaling significantly decreased viability of colon cancer cells due to apoptosis and cell cycle arrest through down regulation of Bcl 2 , Bcl 10 ( L ) , Mcl 1 , and cyclin D 2 and up regulation of p 21 ( waf1 / cip1 ) and p 27 ( kip 1 ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Down regulation of the expression of BCL 2 and BCL 10 ( L ) by RNA interference showed the important role of BCL 2 and BCL 10 ( L ) in the survival of M Mphi and GM Mphi , respectively . ^^^ Anti HEC antibody also induced the apoptosis of M Mphi cultured in the presence of M CSF and GM Mphi and A Mphi cultured in the presence or absence of GM CSF and down regulated the expression of BCL 2 and BCL 10 ( L ) in these Mphis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Some defects in the function of PKCtheta ( / ) T cells ( poor survival and reduced Bcl 2 and Bcl 10 ( L ) expression , CTL activity , and IFN gamma expression ) were partially or fully restored by coculture with wild type T cells or by addition of exogenous IL 2 , whereas others ( increased Bim ( EL ) expression and TNF alpha production ) were not . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Such TNF induced NF kappaB regulated gene products involved in cellular proliferation [ cyclooxygenase 2 ( COX 2 ) , cyclin D 1 , and c myc ] , antiapoptosis [ inhibitor of apoptosis protein ( IAP ) 1 , IAP 2 , 10 chromosome linked IAP , Bcl 2 , Bcl 10 ( L ) , Bfl 1 / A1 , TNF receptor associated factor 1 , and cellular Fas associated death domain protein like interleukin 1beta converting enzyme inhibitory protein like inhibitory protein ] , and metastasis ( vascular endothelial growth factor , matrix metalloproteinase 9 , and intercellular adhesion molecule 1 ) were also down regulated by curcumin . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Interactions between the cyclin dependent kinase ( CDK ) inhibitor flavopiridol and histone deacetylase ( HDAC ) inhibitors ( suberoylanilide hydroxamide and sodium butyrate ) were examined in human leukemia cells ( U 937 and HL 60 ) ectopically expressing Bcl 2 / Bcl 10 ( L ) and in primary AML cells . ^^^ Coadministration of flavopiridol with HDAC inhibitors synergistically potentiated mitochondrial damage ( cytochrome c , second mitochondria derived activator of caspases / direct IAP binding protein with low pI , and apoptosis inducing factor release ) , caspase activation , poly ( ADP ribose ) polymerase degradation , and cell death in both wild type and Bcl 2 or Bcl 10 ( L ) overexpressing cells and induced a pronounced loss of clonogenicity . ^^^ In contrast , Bcl 2 and Bcl 10 ( L ) largely blocked these events in cells exposed to the cytotoxic agent 1 beta d arabinofuranosylcytosine ( ara C ) . ^^^ Ectopic expression of Bcl 2 or Bcl 10 ( L ) was also unable to prevent the flavopiridol / HDACI regimen from inducing a conformational change in and mitochondrial translocation of Bax , and it did not attenuate Bax dimerization . ^^^ As a whole , these findings indicate that in contrast to certain conventional cytotoxic agents such as ara C , overexpression of Bcl 2 or Bcl 10 ( L ) are largely ineffective in preventing perturbations in Bax , mitochondrial injury , and cell death in human leukemia cells subjected to simultaneous CDK and HDAC inhibition . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Patterns of expression of Bax , Bcl 2 and Bcl 10 ( L ) in the implantation site in rat during pregnancy . ^^^ Overall Bax and Bcl 2 were expressed from day 8 till day 19 , whilst Bcl 10 ( L ) was extinguished by day 16 . ^^^ The increased levels of active caspase 9 correlated with Bax / Bcl 2 and Bcl 10 ( L ) expression suggesting that the apoptotic mitochondrion dependent pathway is involved in decidual regression during pregnancy progression . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Levels of other Bcl 2 family proteins ( Bcl 2 , Bcl 10 ( L ) , Bad , Bak , Bax ) were unaffected by simultaneous ATRA and TGF beta 1 treatment , when compared to ATRA alone . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Upregulation of caspase 1 , 2 , 3 , 6 , 7 , 8 , 11 and 12 and upregulation for the transcripts of apoptosis inhibitors bcl 2 , bcl w and bcl 10 and apoptosis promoters ' bax , bak and bad was detected in spleens of sPCV and mPCV mice , but not control mice . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In addition , treatment with TGF beta induced binding of Bim , a proapoptotic Bcl 2 homology domain 3 ( BH 3 ) only protein , to Bcl 10 ( L ) , which is dependent on the activation of Smad , and reduction in the expression of Bim by RNA interference decreased the sensitivity to TGF beta induced apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Western blot showed that LPS in high glucose increased the levels of anti apoptotic Bcl 2 and Bcl 10 ( L , ) and did not change proapoptotic Bax . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Expression profiles of genes , c myc , AT 1 , AT 2 , ETA , ETB , Bcl 2 , Bax and Bcl 10 , were determined by reverse transcription polymerase chain reaction ( RT PCR ) in the acute phase , from 1 to 48 h , following CA arteriotomy . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Here , we describe a novel Bcl 10 splice product of 138 amino acids termed Bcl xAK ( Atypical Killer ) , which encloses the Bcl 2 homology domains BH 2 and BH 4 as well as the transmembrane domain , but lacks BH 1 and BH 3 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Future clinical studies need to evaluate combinations of several different ASO targeting multiple key targets , including strategies that reverse functional redundancy of the key target ( e . g . , targeting several Bcl family members including Bcl 2 and Bcl 10 ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
This BEA induced apoptosis in human NSCLC A 549 cells was also accompanied by the up regulation of Bax , Bak , and p Bad and down regulation of p Bcl 2 , but no effect on the levels of Bcl 10 ( L ) or Bad proteins . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Expression of pro apoptotic ( p 53 , p 21 , bax , bak and fas ) and anti apoptotic ( bcl 2 and bcl 10 ) proteins in serous versus mucinous borderline ovarian tumours . ^^^ MATERIALS AND METHODS : Immunohistochemical expression of pro apoptotic ( p 53 , p 21 , bax , bak , fas ) and anti apoptotic proteins ( bcl 2 , bcl 10 ) was determined in 34 borderline ( 19 mucinous , 15 serous ) , 20 benign ( 10 mucinous , 10 serous ) and 28 malignant ovarian tumours ( 9 mucinous , 19 serous ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In addition , chalcone also triggered the mitochondrial apoptotic signaling by increasing the amount of Bax and Bak and reducing the level of Bcl 2 and Bcl 10 ( L ) , and subsequently activated caspase 9 in MCF 7 and MDA MB 231 cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In addition , inhibition of PI 3 kinase did not alter levels of Bax , Bcl 2 , Bcl 10 ( L ) or Bim proteins in mitochondria but caused translocation of the pro apoptotic protein Bad to mitochondria . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
TNF induced expression of NF kappaB regulated gene products involved in cell proliferation ( cyclin D 1 , COX 2 , c myc ) , antiapoptosis ( IAP 1 , Bcl 2 , Bcl 10 ( L ) , Bfl 1 / A1 , TRAF 1 and cFLIP ) , and invasion ( MMP 9 ) were also downregulated by the saponin . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
A decrease in expression of Bcl 2 , Bcl 10 ( L ) and pro caspase 3 was observed after exposure to 40 microM curcumin , while the levels of p 53 and Bax were increased in the curcumin treated cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Cytotrophoblasts also expressed a 2 fold higher level of p 53 , a 2 fold lower level of 60 kDa Mdm 2 protein , a 2 fold higher level of Bak , but no differences in the expression of 90 kDa Mdm 2 , Bcl 2 , Bcl 10 ( L ) , Mcl 1 , Bax , Bad , and Bad phosphorylated at the serine ( 112 ) , serine ( 136 ) , or serine ( 155 ) sites , compared to the syncytiotrophoblasts . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
These observations corresponded with the down regulation of the expression of anti apoptotic ( IAP 1 , IAP 2 , 10 chromosome linked IAP , Bcl 2 , Bcl 10 ( L ) , TRAF 1 , FLIP , and survivin ) , proliferative ( cyclin D 1 , cyclooxygenase 2 , and c Myc ) , and angiogenic ( ICAM 1 , matrix metalloproteinase 9 , and vascular endothelial growth factor ) gene products . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The down regulation of the cyclin A , Bcl 2 , and Bcl 10 ( L ) expression with the simultaneous up regulation of the p 21 and Bax expression , and caspase 9 activation was observed in ECSC after bufalin treatment . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In the study of the molecular mechanism of this phenomenon , it was found that GnTV AS reduced the expressions of anti apoptotic proteins , such as phosphorylated protein kinase B and phosphorylated Bad as well as Bcl 2 and Bcl 10 ( L ) , and elevated those of pro apoptotic proteins , including Bax , full length caspase 3 and its activated fragments as well as anti oncoprotein p 53 . ^^^ The increased active caspase 3 was the consequence of the elevated Bax / Bcl 2 ( Bcl 10 ( L ) ) activity ratio in the cells . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The antiapoptotic proteins Bcl 10 ( L ) and Bcl 2 play key roles in the maintenance of normal cellular homeostasis . ^^^ This makes Bcl 10 ( L ) and Bcl 2 attractive targets for the development of potential anticancer agents . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
AIMS : The distribution of glutamate cycle related proteins ( glutamine synthetase ( GS ) and GLAST ) and anti apoptotic proteins ( Bcl 2 and Bcl 10 ) was investigated in Mller cells during early human retinal development , relative to the onset of expression of synaptophysin , a presynaptic vesicle protein . ^^^ METHODS : Using frozen sections of human fetal eyes ( 13 22 weeks gestation ) ( n = 10 ) , Bcl 2 , Bcl 10 , GS , GLAST , and synaptophysin immunoreactivities ( IR ) were imaged using fluorescence microscopy and plotted as a function of eccentricity from the incipient fovea . ^^^ Frozen sections of adult human retina ( n = 4 ) were immunolabelled with antibodies to Bcl 2 and Bcl 10 . ^^^ Within the synaptophysin IR region , mature ( differentiated ) Mller cells expressed both Bcl 2 and Bcl 10 IR from 13 weeks gestation , ahead of GS IR and GLAST IR that were first seen at 14 weeks gestation . ^^^ Additionally , from as early as 13 weeks gestation , ganglion cells and immature neuronal progenitor cells across the entire retina expressed Bcl 2 IR and Bcl 10 IR , respectively . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
BAY 43 9006 ( sorafenib ) down modulates the levels of Bcl 2 and Bcl 10 ( L ) in a MAPK independent manner in A 2058 and SKMEL 5 melanoma cells but not in the more resistant A 375 cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Overexpressed Bcl 10 ( L ) prevents bacterial superantigen induced apoptosis of thymocytes in vitro . bcl 10 , a homologous gene of bcl 2 , has an anti apoptotic function and appears to play a critical role in the development of lymphoid systems . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
To determine whether this phenomenon results from altered expression of Bcl 2 or related proteins , Northern and Western analysis was employed to assess the effects of bryostatin 1 and other PKC activators on steady state levels of Bcl 2 , Bax , Bcl 10 , and Mcl 1 mRNA and protein . ^^^ These effects were accompanied by unaltered expression of Bcl 2 , Bax , and Bcl 10 ( L ) , and by a further increase in Mcl 1 protein levels . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The analyzed genes were bax , bcl 2 and bcl 10 , with known responses to genotoxic stress ( bcl 2 ) or ionising radiation ( bax and bcl 10 ) in MCF 7 human breast cancer cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Immunofluorescence analysis indicates that ( DIPP L Leu ) 2 L LysOCH 3 induced upregulation of pro apoptotic Bax and downregulation of anti apoptotic Bcl 2 and Bcl 10 ( L ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
At concentrations at least 300 microM , expressions of antiapoptotic factors nuclear factor kappaB , Bcl 2 , and Bcl 10 ( L ) were markedly decreased . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Surprisingly , there was no differential expression of important proteins like Bcl 10 ( L ) , Bcl 2 or Bax that might explain enhanced apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Hepatic mRNA levels were measured for several pro apoptotic adaptors / regulators , including FasL , Fas receptor , FADD , TRADD , Bad , Bak , Bax , and Bcl 10 ( S ) , and anti apoptotic regulators , including Bcl w , Bcl 10 ( L ) , Bcl 2 , and Bfl 1 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
These responses on UVB and / or sanguinarine treatments were associated with ( a ) decrease in Bcl 2 and Bcl 10 ( L ) and ( b ) increase in Bax , Bid , and Bak protein levels . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In the fraction of surviving melanocytes , that is , cells with morphologically unchanged nucleus , the antiapoptotic proteins Bcl 2 and Bcl 10 ( L ) were translocated to mitochondria following UVA / B . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Moreover , the anti apoptotic proteins Bcl 2 and Bcl 10 were down regulated , whereas pro apoptotic protein Bax remained unchanged . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Fhit could also partially restore sensitivity to cisplatin in Bcl 2 and Bcl 10 ( L ) overexpressing H 460 cells that are normally resistant to this drug . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In addition , Notch 1 down regulation also induced apoptosis , which could be due to decreased Bcl 2 and Bcl 10 ( L ) protein expression in pancreatic cancer cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
For instance , the cell signaling pathways inhibited by curcumin alone include NF kappaB , AP 1 , STAT 3 , Akt , Bcl 2 , Bcl 10 ( L ) , caspases , PARP , IKK , EGFR , HER 2 , JNK , MAPK , COX 2 , and 5 LOX . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Finally , LY 333531 treatment resulted in the induction of apoptosis of anti IgM activated B cells , which corroborated with their inability to up regulate pro survival factors , Bcl 10 ( L ) and Bcl 2 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Among proapoptotic proteins , Bax expression was activated in H ( 2 ) S treated cells but not Bid , and the antiapoptotic proteins Bcl 10 ( L ) and Bcl 2 did not show any activation in pancreatic acinar cell apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
This was associated with an increased level of CEA specific CD 4 ( + ) and CD 8 ( + ) T cell responses , induction of antigen spreading to p 53 and gp 70 , increased accumulation of CEA specific T cells in the tumor microenvironment , and increased expression of bcl 10 ( L ) and bcl 2 in CD 4 ( + ) and CD 8 ( + ) T cells in vaccinated mice . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
RESULTS : Etoposide treatment ( 1 ) induced apoptosis in one clone , ES , but not in another clone , ER , ( 2 ) had no effect on the expression of the antiapoptotic proteins Bcl 2 and Bcl 10 ( L ) in both cell clones , whereas the proapoptotic proteins Bak and Bax were dramatically upregulated in ES , but not ER cells , and ( 3 ) induced more extensive processing of procaspase 8 , procaspase 9 , and the caspase 3 targeted substrates , topoisomerase 1 and PARP , in ES cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We investigated the role of the mitogen activated protein kinase ( MAPK ) signaling pathway ( ie , ERK1 / 2 ) and apoptosis regulating Bcl 2 family members ( ie , Bcl 10 ( L ) and Bax ) in the resolution of a rat carrageenan induced pleurisy model . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Analysis of Bcl11b ( / ) DN 4 thymocytes showed apoptosis , accompanied with lower expression of anti apoptotic proteins , Bcl 10 ( L ) and Bcl 2 , than wild type DN 4 thymocytes . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Protection of human macrophages required phosphoinositide 3 kinase ( PI3K ) , extracellular signal regulated kinase 1 / 2 ( ERK1 / 2 ) , and Ca2+ signaling , and correlated with Bcl 10 ( L ) and Bcl 2 up regulation as well as Ser 136 Bad phosphorylation . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Sections of the pons of PSN with and without hypoglycemia were stained using terminal deoxynucleotidyl transferase mediated deoxyuridine triphosphate nick end labeling ( TUNEL ) and immunohistochemistry for glial fibrillary acidic protein ( GFAP ) , Bcl 2 , Bcl 10 and activated caspase 3 . ^^^ Additionally , we performed immunoblot analysis of Bcl 2 , Bcl 10 and activated caspase 3 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In this review , we discuss the potential role of molecules involved in altered B cell longevity , especially molecules involved in apoptosis ( bcl 2 , bcl 10 , mutations in the Fas / Fas L pathway ) , as well as molecules that might alter activation thresholds of B cells ( CD 19 , CD 21 , CD 22 , lyn , SHP , SHIP 1 ) in the development of autoimmunity . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
T / t common expression in HER2 / neu overexpressing SK OV 3 cancer cells led to down regulation of Bcl 2 and Bcl 10 ( L ) , and overexpression of Bcl 2 could inhibit the ability of T / t common to induce apoptosis in these cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Antiapoptotic BCL 2 and BCL 10 ( L ) are antiproliferative by facilitating G 0 . ^^^ BAD antagonizes both the cell cycle and antiapoptotic functions of BCL 2 and BCL 10 ( L ) through BH 3 binding . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Three groups of the Bcl 2 family proteins can be distinguished : the antiapoptotic proteins , like Bcl 2 and Bcl 10 L , the pro apoptotic members e . g . , Bax , Bak and the BH 3 only proteins . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 , Bcl 10 ( L ) ) proteins that regulate mitochondrial outer membrane integrity , cytochrome c release and caspase activation . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
A significantly increased activation of caspase 3 and 7 , decreased levels of antiapoptotic proteins Bcl 2 and Bcl 10 ( L ) , and increased levels of proapoptotic protein Bax was observed in the developing cerebral cortex of hypothyroid rats , compared with the euthyroid ( P < 0 . 001 ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
This study examined the expression of the bcl 2 t ( 14 ; 18 ) translocation , the bcl 10 gene , and high expression of bcl 6 mRNA in PIOL cells . ^^^ METHODS : Microdissection and PCR analysis were used to examine vitreous specimens in patients with PIOL for the presence of bcl 2 t ( 14 ; 18 ) translocations , the bcl 10 gene , and expression of bcl 6 mRNA . ^^^ CONCLUSIONS : PIOL has unique molecular patterns of bcl 2 , bcl 10 , and bcl 6 when compared with other systemic lymphomas . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Reverse transcription polymerase chain reaction and immunoblotting results indicated that treatments of cells with beta lapachone resulted in down regulation of anti apoptotic Bcl 2 and Bcl 10 ( L ) and up regulation of pro apoptotic Bax expression . beta Lapachone induced apoptosis was associated with a proteolytic activation of caspase 3 and 9 and degradation of poly ( ADP ribose ) polymerase protein . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
METHODS : The immunohistochemical expression of Bcl 2 gene family members ( Bcl 2 and Bcl 10 ( L ) ) and p 53 was evaluated in 81 surgical specimens of primary human colorectal cancers to establish the role of these genes in colorectal cancer and to evaluate their prognostic importance . ^^^ The expression of p 53 correlated with less differentiated status and with perineural invasion . p 53 expression showed negative correlation with Bcl 10 ( L ) expression ( P = 0 . 025 ) and no correlation with Bcl 2 expression . ^^^ Bcl 2 and Bcl 10 ( L ) may play an independent role in disease progression , and the expression of these proteins may be under independent regulatory control in colorectal cancer . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The mRNA and protein levels of c Myc , Bcl 10 ( L ) and Bcl 2 were downregulated , whereas the expression of p 53 and bax was upregulated in mPER 2 overexpressing LLC cells compared with control cells transferred with empty plasmid . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Our results indicated that : ( 1 ) the hippocampus volume significantly increased from P 5 to P 60 , although the number of neurons remained stable in all studied stages ; ( 2 ) the number of apoptotic cells was highest at P 45 , based either on the Nissl staining or on the immunohistochemistry for caspase 3 ; ( 3 ) Bcl 2 mRNA expression was high from P 5 to adulthood , while Bax mRNA declined abruptly from P 5 to adulthood , and Bcl 10 mRNA was high after P 45 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
However , the expressions of p 53 or pro or antiapoptotic Bcl 2 family proteins ( Bax , Bcl 2 , Bcl 10 ( L ) and Mcl 1 ) were not affected in any of the cell lines even after prolonged exposure to FB ( 1 ) at high doses . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Its three factions of interacting proteins include the BH 3 only proteins ( e . g . , Bim , Puma , Bad , Noxa ) , which transduce diverse cytotoxic signals to the mammalian pro survival proteins ( Bcl 2 , Bcl 10 ( L ) , Bcl w , Mcl 1 , A 1 ) , whereas Bax and Bak , when freed from pro survival constraint , provoke the mitochondrial permeabilization that triggers apoptosis . ^^^ Furthermore , Mcl 1 and Bcl 10 ( L ) , but not Bcl 2 , directly sequester Bak in healthy cells , and Bak is freed only when BH 3 only proteins neutralize both its guards . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Tissue microarray analysis of FAS , Bcl 2 , Bcl 10 , ER , PgR , Hsp 60 , p 53 and Her 2 neu in breast carcinoma . ^^^ Fatty acid synthase , bcl 2 , bcl 10 , p 53 , estrogen and progesterone receptors , heat shock protein 60 and Her 2 neu ( c erbB 2 ) were evaluated in a group of 149 breast carcinoma patients with a 5 year follow up period . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
AMR induced apoptosis was accompanied by redistribution of cytochrome c from mitochondria to cytosol as well as down regulation of Bcl 2 and Bcl 10 ( L ) proteins in a dose dependent manner . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
EGF increased the expression of the Bcl 10 ( L ) protein , an antiapoptotic member of the Bcl 2 family , but not that of other anti ( Bcl 2 ) or proapoptotic ( Bad and Bax ) protein members . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
MVA also induced apoptosis in DCs more rapidly than 10 , and DC apoptosis after MVA infection was associated with an accelerated decline in the levels of intracellular Bcl 2 and Bcl 10 ( L ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The expression of NF kappaB regulated gene products involved in antiapoptosis ( IAP 1 , IAP 2 , Bcl 10 ( L ) , Bcl 2 , cFLIP , TRAF 1 , and survivin ) , proliferation ( cyclin D 1 , cyclooxygenase 2 , and c myc ) , invasion ( matrix metalloproteinase 9 and intercellular adhesion molecule 1 ) , and angiogenesis ( vascular endothelial growth factor ) were also down regulated by honokiol . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We have identified a novel cellular protein , Bik , that interacts with the cellular survival promoting proteins , Bcl 2 and Bcl xL , as well as the viral survival promoting proteins , Epstein Barr virus BHRF 1 and adenovirus E1B 19 kDa . ^^^ This death promoting activity of Bik can be suppressed by coexpression of Bcl 2 , Bcl XL , EBV BHRF 1 and E1B 19 kDa proteins suggesting that Bik may be a common target for both cellular and viral anti apoptotic proteins . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Here , we show that Bcl xL , a protein homologue of Bcl 2 , is highly regulated in the thymus in a pattern different than that of Bcl 2 . ^^^ These studies demonstrate that Bcl 2 and Bcl xL , two functionally related proteins , are regulated independently during T cell development . ^^^ In contrast to Bcl 2 , which has been implicated in the maintenance of mature T cells , Bcl xL appears to provide a survival signal for the maintenance of more immature CD4+CD8+ thymocytes before positive selection . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Using both stable transfectants and transient transfections , overexpression of Bcl 2 or Bcl xL readily blocked glucocorticoid induced but not activation induced apoptosis of 2B4 cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We investigated the influence of bcl xL , a member of the bcl 2 family of apoptosis regulatory genes , on apoptosis in a model system for negative selection in the B lymphoid lineage . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Comparison of amino acid ( aa ) sequences derived from nucleotide ( nt ) sequences of xR 1 and xR 11 cDNAs revealed substantial homology with bcl 2 related genes , especially with bcl xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Although CD 28 signal transduction had no effect on Bcl 2 expression , CD 28 costimulation was found to augment the expression of Bcl XL substantially . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl XL and Bcl 2 repress a common pathway of cell death . ^^^ Overall , the phenotype of Bcl xL transgenics was essentially indistinguishable from a Bcl 2 transgenic model . ^^^ Overexpression of Bcl xL or Bcl 2 resulted in the down regulation of the other molecule , providing further evidence of their reciprocal regulation . ^^^ In a genetic test of redundancy , the Bcl xL transgene rescued mature T cells in Bcl 2 null mice . ^^^ Immunoprecipitation indicated that Bcl xL , like Bcl 2 , heterodimerized with the death promoting molecule Bax in thymocytes . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
This protein , which is expressed in a wide variety of cell types , binds to E1B 19K and to the Bcl 2 homologue Bcl XL ( ref . 17 ) in yeast . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We report that Bcl XL , which functions like Bcl 2 to inhibit apoptosis , is highly expressed in MCF 7 human breast carcinoma cells . ^^^ We used Bcl XS , a dominant negative inhibitor of Bcl 2 and Bcl XL , to demonstrate the role of these genes in modulating chemotherapy induced apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Activation of the Ras pathway by using an inducible oncogenic Ras resulted in the rapid up regulation of bcl 2 and bcl xL , and the level of expression was nearly equivalent to that observed in growing cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In contrast , we show that U A 20 and U V 20 cells overexpress the Bcl 2 related protein , Bcl xL . ^^^ These findings suggest that , unlike Bcl 2 , Bcl XL may be constitutively overexpressed as a result of selection for cytotoxic drug resistance and that Bcl XL participates in an acquired form of multimodality resistance to chemotherapeutic agents and radiation . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bad , a heterodimeric partner for Bcl XL and Bcl 2 , displaces Bax and promotes cell death . ^^^ Bad selectively dimerized with Bcl xL as well as Bcl 2 , but not with Bax , Bcl xs , Mcl 1 , A 1 , or itself . ^^^ Bad binds more strongly to Bcl xL than Bcl 2 in mammalian cells , and it reversed the death repressor activity of Bcl xL , but not that of Bcl 2 . ^^^ The susceptibility of a cell to a death signal is determined by these competing dimerizations in which levels of Bad influence the effectiveness of Bcl 2 versus Bcl xL in repressing death . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Some members of the BCL 2 family ( bcl 2 alpha , bcl xL ) inhibit apoptosis , whereas some other ( Bax , Bclxs ) induce it . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In contrast to HL 60 , another immature myeloid cell line , K 562 , did not produce Bcl 2 but expressed a related protein , Bcl xL , that functions as a repressor of apoptotic cell death . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The apoptosis induced by cisplatin treatment or murine ICE overexpression can be suppressed by the tetrapeptide ICE inhibitor Ac YVAD CMK or the apoptosis inhibitors bcl 2 or bcl 2 related bcl XL gene . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The finding that both IR induced proteolytic activation of PKC delta and endonucleolytic DNA fragmentation are blocked by Bcl 2 and Bcl xL supports an association with physiological cell death ( PCD ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
To distinguish between these two models with respect to granulocyte colony stimulating factor ( G CSF ) and granulocytic differentiation , we used the 32Dcl3 cell line , which is capable of differentiating into granulocytes in response to G CSF , 32D cells transfected with either bcl 2 or bcl XL showed prolonged survival in medium containing no cytokine supplement . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Prevention of apoptosis by CD 28 costimulation was associated with increased expression of bcl xL , while overexpression of bcl 2 in T cells from bcl 2 transgenic mice was not protective . ^^^ In addition , the results further suggest that bcl 2 and bcl xL regulate T cell survival under different conditions , with bcl xL being perhaps more important in maintaining viability of activated T cells traversing the cell cycle . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The Bcl 2 related protein , Bcl XL , has been shown to block apoptosis induced by a variety of stimuli and to be a stronger protector against apoptosis than Bcl 2 under certain circumstances . ^^^ Using site specific mutagenesis , we show here that the amino acid residues critical for protection of cells by Bcl XL against Sindbis virus induced apoptosis are clustered within the Bcl 2 homology regions 1 and 2 ( BH 1 and BH 2 regions ) . ^^^ The residues necessary for Bcl XL function are not identical to those required for Bcl 2 function . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Isolation and characterization of an apoptosis resistant variant of human leukemia HL 60 cells that has switched expression from Bcl 2 to Bcl xL . ^^^ Thus , the Bcl 2 independent resistance of HCW 2 cells to apoptotic induction is discussed in terms of the expression of bcl xL . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We found that human erythroleukemia ( HEL ) and K 562 , two leukemia cell lines that undergo erythroid differentiation do not express Bcl 2 , but express Bcl XL , a related protein that functions as an inhibitor of apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Interleukin 2 receptor common gamma chain signaling cytokines regulate activated T cell apoptosis in response to growth factor withdrawal : selective induction of anti apoptotic ( bcl 2 , bcl xL ) but not pro apoptotic ( bax , bcl xS ) gene expression . ^^^ This rescue involves the induction of the anti apoptosis genes bcl 2 and bcl xL ) , but causes little change in expression of bax and bcl xS , which promote apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 and Bcl xL function upstream of the CED 3 like apoptotic proteases . ^^^ Our results establish that Bcl 2 and Bcl xL function upstream of two members of the ICE / CED 3 family of cysteine proteases , Yama ( CPP32 / apopain ) and ICE LAP 3 ( Mch 3 ) . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Response type does not correlate with previously published values for expression of the apoptosis modulators Bcl 2 , Bcl XL , wildtype p 53 , or , in medulloblastoma lines , p75 . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The ability of TGF beta 1 to increase the expression of the anti apoptotic proteins Bcl 2 and Bcl XL is discussed in this context . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We report here that apoptosis induced by PMA , sphingosine , and N , N dimethylsphingosine ( DMS ) was accompanied by a concomitant decrease of bcl 2 expression in both RNA and protein levels in HL 60 cells , while expression of bcl XL and bax mRNA did not change , and neither sphingosine nor DMS induced differentiation of HL 60 cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Overexpression of the anti apoptotic proteins Bcl 2 or Bcl xL inhibits the cell death and the activation of ICE ( like ) and CPP32 / Yama ( like ) proteases , indicating that Bcl 2 and Bcl xL act upstream of these proteases . ^^^ Induction of necrotic cell death by KCN also induces activation of ICE ( like ) proteases but not of CPP32 / Yama ( like ) proteases , and Bcl 2 and Bcl xL inhibit the activation and the cell death , suggesting that the functional site of Bcl 2 and Bcl xL is also upstream of ICE ( like ) proteases in at least some forms of necrosis . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Association of bcl 2 , bax , bcl xL and interleukin 1 beta converting enzyme expression with initial response to chemotherapy in acute myeloid leukemia . ^^^ In this study we determined the role of bcl 2 to bax expression ratio , bcl xL and ICE expression level for predicting clinical response to chemotherapy in acute myelold leukemia ( AML ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
One of these , designated bcl xalpha , was a counterpart of the human bcl xL reported previously as a bcl 2 related gene ( Boise , L . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The susceptibility of normal and cancer cells to induction of apoptosis is also regulated by the balance between apoptosis inducing genes such as the tumor suppressor wild type p 53 , and c myc and bax , and apoptosis suppressing genes such as the oncogene mutant p 53 , and bcl 2 and bcl XL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The anti apoptotic proteins Bcl 2 and Bcl xL effectively retard the chemical hypoxia induced necrotic cell death . ^^^ These results indicate that Bcl 2 / Bcl xL and ICE ( like ) proteases modulate apoptotic and at least some forms of necrotic cell death . ^^^ Both cell death pathways appear to involve some common mediators ; however necrotic or apoptotic cell death signals might be transduced through multiple pathways , because Bcl 2 / Bcl xL or inhibitors of ICE ( like ) proteases are relatively less potent in blocking necrotic cell death than in preventing apoptosis . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The authors examined the expression of the apoptosis related modulators , Fas ( receptor ) , Fas ligand , Bax , Bcl 2 , Bcl XL , and interleukin 1 beta converting enzyme ( ICE ) in corneal cells as candidate mediators of this response and tested the effect of Fas receptor stimulating antibody on corneal stromal fibroblast cells in vitro . ^^^ METHODS : Reverse transcription polymerase chain reaction was used to detect FAS , FAS ligand , Bax , Bcl 2 , Bcl XL , and ICE mRNA expression in primary cultures of human corneal epithelial , stromal fibroblast , and endothelial cells . ^^^ RESULTS : FAS , Fas ligand , Bax , Bcl 2 , Bcl XL , and ICE mRNAs are expressed in all three major cell types of the cornea . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
IR upregulated p 53 and p21WAF1 about 5 to 10 fold and downregulated bcl 2 and bcl XL by 80 90 % at 6 hr in both parent and bax stably transfected MCF 7 cells to the same degree . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The gamma IFN dependent protection was due neither to down regulation of p 53 , nor to the p 53 induced genes , p 21 ( WAF 1 ) and bax , nor to up regulation of bcl 2 or bcl xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Both apoptosis suppressing Bcl 2 and Bcl XL proteins were undectable in U 937 / WT cells , whereas Bcl 2 was nearly detectable and Bcl XL readily detectable in U 937 / RV cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 , Bcl xL , CrmA and tetrapeptide ICE inhibitor reduce the extent of necrotic cell death induced by cyanide , which primarily damages mitochondria . ^^^ Although none of them affects the drastic decrease in ATP levels induced by cyanide , Bcl 2 and Bcl xL but not CrmA or ICE inhibitor inhibit the cyanide induced decrease in mitochondrial membrane potential . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In contrast , irradiation reduced by 50 70 % the abundances of most other mRNAs tested , including those for housekeeping proteins , p 53 , Jun , Myc , interleukin 1 beta converting enzyme , and the negative apoptosis regulators Bcl 2 and Bcl xL . ^^^ These results indicate that radiation elicited apoptosis of fetal brain cells is associated with activation of the p 53 system , probable increases in AP 1 Fos / JunB heterodimers , and an increased ratio of Bax to Bcl 2 + Bcl xL . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We demonstrate that the Bfl 1 protein suppresses apoptosis induced by the p 53 tumor suppressor protein in a manner similar to other Bcl 2 family members such as Bcl 2 , Bcl xL and EBV BHRF 1 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Erythropoietin can promote erythroid progenitor survival by repressing apoptosis through Bcl XL and Bcl 2 . ^^^ When HCD 57 cells were cultured in the absence of Epo , Bcl 2 and Bcl XL but not Bax were downregulated , and the cells underwent apoptotic cell death . ^^^ HCD 57 cells infected with a retroviral vector encoding human Bcl XL or Bcl 2 rapidly stopped proliferating but remained viable in the absence of Epo . ^^^ Furthermore , endogenous levels of bcl 2 and bcl XL were downregulated after Epo withdrawal in HCD 57 cells that remained viable through ectopic expression of human Bcl XL , further indicating that Epo specifically maintains the expression of bcl 2 and bcl XL . ^^^ Thus , we propose a model whereby Epo functions as a survival factor by repressing apoptosis through Bcl XL and Bcl 2 during proliferation and differentiation of erythroid progenitors . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bax , a member of the Bcl 2 family of proteins , has been shown to promote apoptosis while other members of the family , including Bcl XL and Bcl 2 , inhibit cell death induced by a variety of stimuli . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The pattern of expression of Bcl 2 , Bcl xL , Bcl xS and Bax genes , selected because of their interrelated role in the control of apoptosis , was analysed in a series of CD5+ B cell chronic lymphoid leukaemias . ^^^ According to the functional role of Bcl 2 , Bcl xL , Bcl xS and Bax , these data indicate that the pattern of Bcl 2 family genes expression in leukaemic CD5+ B cells is skewed toward prevention of apoptosis and may thus favour the relentless accumulation of CD5+ leukaemic B cells . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Overexpression of Bcl 2 or Bcl xL inhibits Ara C induced CPP32 / Yama protease activity and apoptosis of human acute myelogenous leukemia HL 60 cells . ^^^ In the present studies , we determined the effect of high intracellular levels of the antiapoptosis Bcl 2 or Bcl xL protein on Yama protease activation and PARP degradation during Ara C induced apoptosis . ^^^ For this , we utilized HL 60 / Bcl 2 , HL 60 / Bcl xL , or control HL 60 / neo cells , which were created by transfection of the cDNA of the bcl 2 , bcl xL , or the neomycin resistant genes , respectively . ^^^ As compared to HL 60 / neo , HL 60 / Bcl 2 and HL 60 / Bcl xL cells have 5 fold greater expression of Bcl 2 and Bcl xL , respectively . ^^^ In contrast , in HL 60 / Bcl 2 and HL 60 / Bcl xL cells , Ara C induced p32Yama activation by its cleavage , PARP degradation and apoptosis were significantly inhibited . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In differentiated H 19 7 cells , the survival time was increased by both human bcl 2 and bcl xL , and this could be reversed by bcl xs . ^^^ Addition of a peptide inhibitor of the ICE enzyme family to H 19 7 cells resulted in a transient protection against differentiation associated apoptosis , whereas no further protection was observed in the BCL 2 or BCL XL expressing cells . ^^^ This medium induced decrease in cell survival could not be rescued by the ICE inhibitor but was partially rescued by BCL 2 or BCL XL . ^^^ Furthermore , studies involving expression of BCL 2 and BCL XL alone or together revealed differences in the survival dependent on the cellular environment . ^^^ The data implicate the ICE enzyme family but not p 53 in apoptosis induced by differentiation and demonstrate that either BCL 2 or BCL XL can prolong the survival of differentiated neuronal cells . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Suppression of apoptosis by Bcl 2 or Bcl xL promotes susceptibility to mutagenesis . ^^^ Bcl 2 , and the related protein Bcl xL , each suppress apoptosis induced by a wide variety of stimuli in many different cell types . ^^^ Here we report that suppression of apoptosis by Bcl 2 or Bcl xL markedly elevates the levels of radiation induced mutations . ^^^ Ectopic expression of either Bcl 2 or Bcl xL enhances radiation mutagenesis in cells with wtp 53 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
This spontaneous cell death could be prevented by interleukin 2 ( IL 2 ) and was related to a decreased expression of Bcl 2 but not Bax or Bcl XL , additional molecules that promote or prevent apoptosis , respectively , as well as an increase in CD 95 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Survival signaling by enforced expression of eIF4E did not result from autocrine release of survival factors , nor did it lead to increased expression of the apoptosis antagonists Bcl 2 and Bcl XL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Since T cells normally express Bcl 2 and Bcl xL following activation , their inability to block Fas mediated apoptosis may allow for the elimination of self reactive cells and the appropriate regulation of immune responses . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
As compared to HL 60 / neo , HL 60 / Bcl 2 cells contained significantly higher ( approximately 10 fold ) p26Bcl 2 , but equivalent levels of Bax and undetectable levels of Bcl xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
CD 40 ligation protected cells from apoptosis induced by calcium ionophore through an initial , rapid and apparently Bcl 2 independent mechanism , associated with up regulation of Bcl XL . ^^^ In contrast , IL 4 did not up regulate Bcl 2 or Bcl XL and did not inhibit apoptosis induced by inhibitors of macromolecular synthesis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Overexpression of Bcl 2 or Bcl XL transgenes and photoreceptor degeneration . ^^^ PURPOSE : To test the hypothesis that overexpression of genes coding for the anti apoptotic proteins Bcl 2 or Bcl XL in photoreceptor cells may prevent or delay photoreceptor degenerations . ^^^ METHODS : Transgenic mice were generated in which the bcl 2 or bcl XL transgenes were expressed in photoreceptor cells under the transcriptional control of a rhodopsin gene promoter . ^^^ Bcl 2 or bcl XL transgenic mice were crossed separately to a mouse strain carrying the rd / rd mutation and to another mouse line carrying a dominant rhodopsin gene mutation ; both genetic defects result in photoreceptor degeneration . ^^^ Bcl 2 and bcl XL transgenic mice also were tested for possible resistance to light induced photoreceptor damage under two different experimental conditions . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The solution properties of Bcl 2 ( 1 203 ) suggest that it consists of two noncovalently associated domains connected by a long protease sensitive linker and that its structure is similar to that of Bcl xL , which has been determined by 10 ray and NMR analysis . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Immunoblotting revealed that BAX transfectants expressed a mean of 10 fold increased levels of BAX compared with neo transfected control clones , with similar levels of BCL 2 and BCL xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We speculated that IGF IR activation could afford neuroprotection either by effecting the negative regulators of the death pathway , Bcl 2 and Bcl xL , or by altering activity of the ced 3 / ICE like proteases . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
CpG DNA reversed anti IgM induced down regulation of c myc expression in WEHI 231 and up regulated myn , bcl 2 , and bcl xL mRNA expression . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Since the discovery of Bcl 2 a decade ago , several other cellular and viral genes encoding homologous proteins have been identified , some of which suppress cell death akin to Bcl 2 ( Bcl XL , Mcl 1 , A1 / Bfl 1 , Nr 13 , Ced 9 , BHRF 1 ) and others which promote apoptosis ( Bax , Bcl Xs , Bak , Bik , Bad ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
All lines showed constitutive expression of bcl 2 and bcl XL ( the suppressors of apoptosis ) with low and non inducible levels of bax ( a promoter of apoptosis ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
A fundamental observation in the present study was that although Bcl 2 was reduced , the levels of Bcl XL was maintained in cytokine deprived T cells by fibroblast co culture . ^^^ The rescued T cell could be re activated by CD 3 antibody , but only in the presence of CD 28 co stimulation , which induced both Bcl 2 and Bcl XL expression and also proliferation . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Recently , K 562 cells have been shown to express the antiapoptosis Bcl xL but not Bcl 2 proteins . ^^^ In contrast , both cell types expressed equivalent levels of Bcl xL , Bax , Bcl 2 , Myc , retinoblastoma , p21cbor abl , and p145abl proteins . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Other research has shown that ( ) deprenyl can induce altered expression of a number of genes in preapoptotic neurons both in vitro and in vivo , including the genes for superoxide dismutase ( SOD ) 1 and 2 , BCL 2 and BCL XL , nitric oxide synthase , c JUN , and nicotinamide adenine dinucleotide dehydrogenase . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In the nervous system , genes have been identified which either 1 ) promote apoptosis : Bax , Bcl xS , c fos , c jun , p75NGFR and ICE like proteases , or 2 ) block apoptosis : Bcl 2 and Bcl xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
This effect of IFN alpha 2 was neither explained by a down regulation of the Apo 1 / Fas receptor nor caused by modulation of the expression levels of c myc , bcl 2 , bcl xL , bax or p 53 genes . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Levels of bcl xL and bcl 2 mRNA were determined by a reverse transcription / polymerase chain reaction in endoscopic gastric biopsy specimens from 10 control subjects , 11 patients with adenomas and 14 patients with carcinomas . ^^^ No correlation was observed between bcl xL and bcl 2 gene expression . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 and Bcl XL antagonize the mitochondrial dysfunction preceding nuclear apoptosis induced by chemotherapeutic agents . ^^^ Transfection enforced hyperexpression of the proto oncogenes bcl 2 and bcl XL protects against chemotherapy induced apoptosis , at both the level of the mitochondrial dysfunction preceding nuclear apoptosis and the level of late nuclear apoptotic events . ^^^ In contrast to Bcl 2 and Bcl XL , hyperexpression of the protease inhibitor cytokine response modifier A fails to protect tumor cells against chemotherapy induced delta psi m disruption and apoptosis , although cytokine response modifier A does prevent the delta psi m collapse and posterior nuclear apoptosis triggered by cross linking of Fas / Apo 1 / CD95 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
These observations indicate that Bcl 2 and Bcl xL are regulated differently in response to wild type p 53 activity and that , while correction of mutant p 53 phenotype may effectively kill cells having Bcl 2 as their major defense against PCD , this is not necessarily the case in cells using Bcl xL as their primary defense . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Overexpression of Bcl 2 , Bcl xL or adenovirus E1B19kD substantially delayed serum stimulation induced S phase entry of quiescent NIH 3T3 fibroblasts . ^^^ Bcl 2 , Bcl xL and E1B19kD , but not Bcl 2 mutants that are defective in blocking apoptosis , suppress growth of colon carcinoma cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Overexpression of P glycoprotein ( PGP ) , MRP or LRP has been characterized as the ' proximal ' , while overexpression of the anti apoptosis Bcl 2 or Bcl xL relative to the pro apoptosis Bax protein has been recognized as the ' distal ' mechanism of multidrug resistance in human AML cells . ^^^ For this , immunoblot analyses were performed to determine the expression of PGP , MRP , Myc , Bcl 2 , Bcl xL and Bax on either the multidrug resistant HL 60 sublines created under the selection pressure of doxorubicin ( HL 60 / AR ) , paclitaxel ( HL 60 / TAX1000 ) or vincristine ( HL 60 / VCR ) , or sublines created by transfection and overexpression of the bcl 2 ( HL 60 / Bcl 2 ) or bcl xL gene ( HL 60 / Bcl xL ) . ^^^ In contrast , enforced and much higher expression of Bcl 2 in HL 60 / Bcl 2 ( five fold ) or Bcl xL in HL 60 / Bcl xL cells ( 10 fold ) significantly reduced paclitaxel induced apoptosis and the loss of cell viability , without affecting its intracellular accumulation . ^^^ In addition , these findings suggest that , for Bcl 2 and Bcl xL , enforced overexpression to high levels is necessary to induce paclitaxel resistance in HL 60 cells . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The process o apoptosis in keratinocytes was dissected at the molecular level and found to be correlated with increased expression of Bax and decreased levels of Bcl XL , with no role for either Bcl 2 or Bcl XS . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The Bcl 2 protein family is characterized by the ability to modulate cell death , and members of this family share two highly conserved domains called Bcl 2 homology 1 ( BH 1 ) and 2 ( BH 2 ) which have been shown to be critical for the death repressor activity of Bcl 2 and Bcl xL . ^^^ Overexpression of KSbcl 2 blocked apoptosis as efficiently as Bcl 2 , Bcl xL , or another viral Bcl 2 homolog encoded by Epstein Barr virus , BHRF 1 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The molecular basis for heterodimer formation was investigated by determination of the solution structure of a complex between the survival protein Bcl xL and the death promoting region of the Bcl 2 related protein Bak . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Synovial T cells from rheumatoid arthritis and gout patients could be rescued from spontaneous apoptosis in vitro either by IL 2R gamma chain signaling cytokines ( which upregulate Bcl 2 and Bcl XL ) or by interaction with synovial fibroblasts ( which upregulates Bcl xL but not Bcl 2 ) . ^^^ The phenotype of rheumatoid synovial T cells ex vivo ( Bcl 2 low , Bcl xL high ) suggested a fibroblast mediated mechanism in vivo . ^^^ This was confirmed by in vitro culture of synovial T cells with fibroblasts which maintained the Bcl xL high Bcl 2 low phenotype . ^^^ Synovial T cells from gout patients were Bcl 2 low Bcl xL low and showed clear evidence of apoptosis in vivo . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The mechanism by which myelomas are immortalized is still unclear , but Bcl 2 , Bcl xL , adult T cell leukemia derived factor ( ADF ) , soluble Fas are all candidate factors for this mechanism . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In order to determine whether the process of programmed cell death is distinct between cord blood and peripheral blood lymphocytes , we analyzed the expression of fas and bax ( apoptosis promoting genes ) and bcl 2 and bcl xL ( apoptosis inhibiting genes ) at protein or mRNA levels using flow cytometry and quantitative PCR methods , respectively . ^^^ We observed that cord blood T cell subsets expressed lower levels of Fas and Bcl 2 , a low bcl 2 / bax ratio , and higher bcl xL compared to peripheral blood . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 , Bcl XL and adenovirus protein E1B19kD are functionally equivalent in their ability to inhibit cell death . ^^^ Survival promoting homologues of Bcl 2 include its close relative , Bcl xL and the 19 kD protein encoded by the E1B gene of adenoviruses . ^^^ We have carried out a systematic comparison of Bcl 2 , Bcl xL and adenovirus E1B19kD activity , using several cell lines and a range of cytotoxic conditions . ^^^ The results provide evidence that Bcl 2 , Bcl xL and adenovirus protein E1B19kD are indistinguishable in their ability to regulate the cell death effector machinery . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Here CED 9 and its mammalian homolog Bcl xL ( a member of the Bcl 2 family of cell death regulators ) were both found to interact with and inhibit the function of CED 4 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In the present studies , we demonstrate that in human AML HL 60 cells that express Bcl 2 but little Bcl xL ( HL 60 / neo cells ) , paclitaxel induced phosphorylation of Bcl 2 is followed by increased intracellular free Bax levels . ^^^ As compared to the control HL 60 / neo , HL 60 / Bcl xL cells contain Bcl 2 as well as an enforced overexpression of Bcl xL . ^^^ Immunoprecipitation studies with anti Bcl 2 and / or anti Bcl 10 antibodies demonstrated that HL 60 / Bcl xL cells possess lower free Bax but higher levels of Bax heterodimerized to Bcl 2 and Bcl xL . ^^^ Following treatment of HL 60 / Bcl xL cells with paclitaxel , although Bcl 2 phosphorylation was observed , it was not followed by increased free Bax levels , cleavage of CPP32beta / Yama and poly ( ADP ribose ) polymerase , or induction of the DNA fragmentation of apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We have shown previously that transfection of WEHI cells with bcl xL conferred resistance to anti IgM induced apoptosis , whereas transfection with bcl 2 did not ( Gottschalk , A . , Boise , L . , Thompson , C . , and Quintans , J . ( 1994 ) Proc . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Hyaluronidase failed to up or downregulate the expression of apoptosis regulatory proteins , including Bcl 2 , Bcl xL , ICH 1 , and TIAR , suggesting that these proteins were not involved in the hyaluronidase induced resistance to TNF / ActD . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Expression and regulation of Bcl 2 , Bcl xl , and Bax correlate with p 53 status and sensitivity to apoptosis in childhood acute lymphoblastic leukemia . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The three dimensional structure of a Bcl 2 homologue , Bcl XL , suggests striking similarity to the pore forming domains of diphtheria toxin and the bacterial colicins , prompting exploration of whether Bcl 2 is capable of forming pores in lipid membranes . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Members of the Bcl 2 family ( including Bcl 2 , Bcl XL , and Bax ) play key roles in the regulation of apoptosis . ^^^ We have found that whereas Bcl 2 is predominantly membrane associated as previously reported , significant amounts of Bcl XL and most of the Bax proteins are not membrane associated and thus appear in the cytosolic fraction of thymocyte and splenocyte extracts . ^^^ For this analysis , we have produced monoclonal antibodies that are specific for known epitopes of Bax , Bcl 2 , and Bcl XL . ^^^ In the presence of nonionic detergent , the 6A7 antibody avidly binds the monomeric form of Bax , but not Bax complexed with either Bcl XL or Bcl 2 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
These data demonstrate that the kinetics of drug induced apoptosis can be modulated by Bcl 2 as well as by IL 4 , vascular cell adhesion molecule 1 , and CD 40 ligation , the latter possibly involving the function of Bcl xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Denervated muscle fibres revealed strong immunoreactivity of the anti apoptotic proteins bcl 2 and bcl xL , and the pro apoptotic factor bax . ^^^ In reinnervated muscle fibres , only bcl 2 was constantly upregulated while bcl xL and bax diminished after the 7th week . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Furthermore , the expression of bcl 2 and bcl XL proteins was decreased in these apoptosis processes . ^^^ Whereas the ligation of MCS 34 alone could not generate apoptosis signals that led to the activation of CPP 32 like proteases and the decrease in bcl 2 and bcl XL expression , the aggregation of Thy 1 glycoprotein might be crucial to signal thymocyte apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bax / Bak lethality was suppressed by coexpression of Bcl 2 family members that are anti apoptotic in vertebrates , namely Bcl xL , Bcl 2 , Mcl 1 , and A 1 . ^^^ Furthermore , Bcl xL and Bcl 2 suppressed Bax toxicity by distinct mechanisms in yeast . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The effects of the expression of the human Bcl 2 family proteins Bax , Bak , Bcl 2 , and Bcl XL were examined in the fission yeast Schizosaccharomyces pombe and compared with Bax induced cell death in mammalian cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The combination of IL 13 with CD40L augmented the expression of the Bcl 2 homologues Bcl xL and Mcl 1 , suggesting this as a possible intracellular mechanism of induced survival . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
On mRNA or protein levels induction of pro and anti apoptotic gene products like fasL , bcl 2 , or bax with minor effects on fas / Apo 1 or bcl XL was observed under culture conditions with both IL 2 and IL 15 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Previous work has shown that the death inhibiting family members Bcl 2 and Bcl xL form heterodimers with the death promoting homologue Bax and that certain site directed mutants of Bcl 2 and Bcl xL lose both biological activity and the ability to bind Bax . ^^^ To better understand the structural basis of heterodimer formation , we have used a yeast two hybrid assay to screen for mutants of Bax that regain the ability to bind to these inactive Bcl 2 ( G145A ) and Bcl xL ( G138A ) mutants . ^^^ These results indicate that while the Bcl 2 and Bcl xL mutants fail to bind full length Bax , they still retain a binding site for the critical BH 3 domain . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Analysis of bi transgenic K rasVal 12 10 TAgWt mice homozygous for wild type or null p 53 alleles established that the enhancement of apoptosis occurs through a p 53 independent mechanism , is not attributable to augmented proliferation or to an increase in abortive cell cycle reentry ( compared to TAgWt mice ) , and is not associated with detectable changes in the crypt villus patterns of expression of apoptotic regulators ( Bcl 2 , Bcl xL , Bak , and Bax ) or mediators of epithelial cell matrix interactions and survival ( e . g . , alpha5beta1 integrin and its ligand , fibronectin ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
They may do this in part by maintaining levels of survival promoting proteins such as Bcl 2 in the cells , because the levels of Bcl 2 and Bcl Xl in resting T cells fall rapidly after the cells are isolated from animals , and are maintained by culture in IL 4 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Expression of the BCL 2 protein family members , BAX , BAK , BAD , BCL xL , BCL xS , and BCL 2 , was measured ( by western blotting using specific antibodies ) in PC 12 cells before and during apoptosis induced by either H2O2 treatment or by serum deprivation and during rescue from apoptosis by nerve growth factor ( NGF ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 and Bcl XL can differentially block chemotherapy induced cell death . ^^^ Bcl 2 and its homologue Bcl XL are expressed in a variety of tumors and their expression modulates the sensitivity of tumor cells to a wide spectrum of chemotherapeutic agents and gamma irradiation . ^^^ In the present report , we generated clones of FL5 . 12 lymphoid cells with similar levels of Bcl 2 and Bcl XL using the Flag epitope to determine if these survival proteins could provide equivalent protection when challenged with chemotherapy or gamma irradiation . ^^^ Using four M phase specific chemotherapeutic agents , Bcl XL and Bcl 2 provided similar protection against vincristine and vinblastine whereas Bcl XL afforded as much as 50 % greater cell viability than Bcl 2 against etoposide and teniposide induced cell death . ^^^ In addition , Bcl XL provided significantly greater cell viability than Bcl 2 against methotrexate , fluorouracil , and hydroxyurea , three S phase specific agents . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Remarkably , reentry of villus enterocytes to the cell cycle increases the radiosensitivity of the crypt epithelium without changing Bcl 2 , Bcl xL , Bak , or Bax expression . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The initial rise of intracellular calcium ions with A 23187 and the expression of P glycoprotein , Bcl 2 , and Bcl Xl were comparable between WT and VC 33 cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
This release is known to be negatively regulated by Bcl 2 and Bcl XL proteins . ^^^ We show here that treatment of human leukemia cells HL 60 with 1 , 25 dihydroxyvitamin D 3 ( 1 , 25D3 ) results in progressive increases in the levels of cellular antiapoptotic protein Mcl 1 , a transient increase in Al protein level , but no increases in Bcl 2 or Bcl XL proteins . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
These lesions also revealed expression of apoptosis promoting factors , such as bax and ICE , inducing cleavage of myofilaments , and of the apoptosis inhibiting proteins bcl XL and bcl 2 which neutralized high bax levels . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
BAD interacts with anti apoptotic molecules BCL 2 and BCL XL and promotes apoptosis . ^^^ Phosphorylated BAD can not bind to BCL XL or BCL 2 at membrane sites and is found in the cytosol bound to 14 3 3 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bik is a potent pro apoptotic protein , which complexes with various anti apoptotic proteins such as Bcl 2 , Bcl xL , 19 kDa adenovirus E1B , and EBV BHRF 1 . ^^^ It shares a conserved domain , BH 3 , with other pro apoptotic proteins , Bax , Bak , Bid , and Hrk , and certain anti apoptosis proteins such as Bcl 2 and Bcl xL . ^^^ This result is consistent with the hypothesis that Bik may promote cell death by complexing with and antagonizing the activity of endogenous cellular anti apoptosis proteins such as Bcl 2 and Bcl xL . ^^^ To elucidate the relationship between protein complex formation and induction of cell death , we have identified the minimal sequences of Bik , from a library of N terminal and C terminal deletion mutants , required for interaction with Bcl 2 and Bcl xL and for inducing efficient cell death . ^^^ Two hybrid analysis in yeast and immunoprecipitation analysis of proteins expressed in mammalian cells indicate that a 52 amino acid region ( amino acids 43 94 ) of Bik , encompassing the BH 3 domain , is sufficient for efficient heterodimerization with Bcl 2 and Bcl xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The ability of BHRF 1 to protect MCF Fas cells from apoptosis induced by various stimuli was identical to that of Bcl 2 and Bcl xL . ^^^ Moreover , the mechanism of action of BHRF 1 resembled that of Bcl 2 and Bcl xL as it inhibited TNF and anti Fas induced activation of two enzymes participating in the apoptosis pathway , cytosolic phospholipase A 2 and caspase 3 / CPP32 , but did not interfere with the activation of NF kappaB like transcription factors . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
TNF + CHX killing is effectively blocked by transfected CrmA protein or treatment with Z VAD . fmk peptide both inhibitors of interleukin 1 converting enzyme like proteases but not by transfected antiapoptotic proteins Bcl 2 , Bcl XL , or A 1 . ^^^ TNF + cer killing , which can affect more than 50 % of EC , is not effectively inhibited by CrmA or Z VAD frank , but can be readily blocked by Bcl 2 , Bcl XL , or A 1 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Inhibition of fusion is prevented by Bcl 2 or Bcl xL , two negative regulators of apoptosis , or by specific inhibitors of members of the caspase family of apoptotic proteases . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
RNA from mammary glands , adenocarcinomas and ovaries was probed for transforming growth factors ( TGF ) alpha and beta , and the apoptotic genes TRPM 2 , ICE , bcl 2 , bcl XL , bcl XS , p 53 and c myc . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bap 31 , a Bcl 2 / Bcl XL and procaspase 8 associated protein in the endoplasmic reticulum . ^^^ In cotransfected 293T cells , p 28 is part of a complex that includes Bcl 2 / Bcl XL and procaspase 8 ( pro FLICE ) . ^^^ Taken together , the results suggest that p 28 Bap31 is part of a complex in the endoplasmic reticulum that mechanically bridges an apoptosis initiating caspase , like procaspase 8 , with the anti apoptotic regulator Bcl 2 or Bcl XL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Protein expression of Fas / APO 1 or bcl 2 , and messenger RNA ( mRNA ) expression of bcl 2 , bcl xL , bax , bak , Fas / APO 1 , Fas ligand ( Fas L ) , c myc , mad , or max were determined . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl xL is a member of the Bcl 2 protein family , which regulates apoptosis . ^^^ Homology modeling of Bcl 2 and Bax , based on the Bcl xL structure , suggests that Bax has the strongest potential for membrane insertion . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In the yeast two hybrid system , Bok interacted strongly with some ( Mcl 1 , BHRF 1 , and Bfl 1 ) but not other ( Bcl 2 , Bcl xL , and Bcl w ) anti apoptotic members . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Caspase dependent apoptosis of COS 7 cells induced by Bax overexpression : differential effects of Bcl 2 and Bcl xL on Bax induced caspase activation and apoptosis . ^^^ We also found that the Bax induced apoptosis of COS 7 cells was suppressed by Bcl xL and Bcl 2 , though both Bcl xL and Bcl 2 similarly prevented etoposide induced apoptosis in COS 7 cells . ^^^ In addition , Bcl xL inhibited the activation of caspase 3 like proteases accompanying Bax induced COS 7 cell death but Bcl 2 did not . ^^^ These results indicate that the caspase activation is essential for Bax induced apoptosis , and that the ability of Bcl 2 and Bcl xL to prevent the Bax induced caspase activation and apoptosis in COS 7 cells could be differentially regulated . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bak can accelerate chemotherapy induced cell death independently of its heterodimerization with Bcl XL and Bcl 2 . ^^^ Bak has been shown to both promote apoptosis and to inhibit cell death while two other members of the Bcl 2 family of proteins , Bcl XL and Bcl 2 delay apoptosis induced by various stimuli including chemotherapeutic agents . ^^^ We generated clones with stable expression of Bak wild type ( wt ) and Bak with its BH 3 ( delta 78 86 ) domain deleted ( deltaBH 3 ) in FL5 . 12 cells or FL5 . 12 cells expressing either Bcl XL or Bcl 2 to determine if Bak could accelerate apoptosis and antagonize the death repressor activity of Bcl XL and Bcl 2 during chemotherapy induced apoptosis . ^^^ Immunoprecipitation studies revealed that deletion of BH 3 disrupted heterodimerization between Bak and Bcl XL and that both Bak wt and Bak deltaBH 3 failed to interact with Bcl 2 . ^^^ Furthermore , Bak can accelerate chemotherapy induced cell death independently of its heterodimerization with Bcl XL and Bcl 2 . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We have studied interactions of human Bax with itself , and with the apoptosis preventing members Bcl 2 and Bcl xL using a yeast two hybrid system . ^^^ Bax interacted similarly with itself as with the apoptosis suppressing family members Bcl 2 and Bcl xL in quantitative two hybrid studies . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Although it has been shown that Bcl 2 exerts anti apoptotic activity by blocking a step ( s ) leading to the activation of caspases , a role for Bcl 2 and Bcl xL downstream of the caspase cascade has remained unclear . ^^^ Here , we show that purified active caspase 3 ( CPP32 / Yama / apopain ) and caspase 1 ( ICE ) induces apoptosis when microinjected into the cytoplasm of cells , confirming our recent observations , and that the apoptosis is not at all prevented by Bcl 2 and Bcl xL , which are overexpressed more than sufficiently to prevent Fas mediated and overexpressed procaspase 1 mediated apoptosis . ^^^ Thus , Bcl 2 and Bcl xL do not act downstream of the caspase cascade . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Interference of BAD ( Bcl xL / Bcl 2 associated death promoter ) induced apoptosis in mammalian cells by 14 3 3 isoforms and P 11 . ^^^ Unlike most other members of the Bcl 2 family , BAD ( Bcl xL / Bcl 2 associated death promoter ) , a death enhancer , has no C terminal transmembrane domain for targeting to the outer mitochondrial membrane and nuclear envelope . ^^^ We hypothesized that BAD , in addition to binding Bcl xL and Bcl 2 , may interact with proteins outside the Bcl 2 family . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The Bcl 2 related protein Bad is a promoter of apoptosis and has been shown to dimerize with the anti apoptotic proteins Bcl 2 and Bcl XL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
To explore Bcl 2 family member localization in living cells , the green fluorescent protein ( GFP ) was fused to the NH 2 termini of Bax , Bcl 2 , and Bcl XL . ^^^ Confocal microscopy performed on living Cos 7 kidney epithelial cells and L 929 fibroblasts revealed that GFP Bcl 2 and GFP Bcl XL had a punctate distribution and colocalized with a mitochondrial marker , whereas GFP Bax was found diffusely throughout the cytosol . ^^^ The diffuse localization of GFP Bax did not change with coexpression of high levels of Bcl 2 or Bcl XL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Identification of a BH 3 domain and analysis of its binding to mutant BCL 2 and BCL XL proteins . ^^^ Furthermore , in yeast two hybrid assays as well as quantitative in vitro interaction assays , human Bad interacted with BCL 2 and BCL XL . ^^^ Thus , as previously shown for BAX , BAK , BCL 2 , and BCL XL , the BH 3 domain of BAD is required for its dimerization with other BCL 2 family proteins . ^^^ BAD was further analyzed for its ability to bind to various mutants of BCL 2 and BCL XL that have lost the ability to bind BAX and BAK , some of which retain biological activity and some of which do not . ^^^ Surprisingly , all of the mutated BCL 2 and BCL XL proteins analyzed strongly interacted with human BAD . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We postulated that Mycobacterium tuberculosis could trigger the apoptotic pathway in macrophages , resulting in death of the microorganism by modulating the expression of bcl 2 , bax , bcl xL , and bcl xS . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Immunoreactive Bcl 2 and Bcl xL proteins were also investigated following two stage exposures . ^^^ Furthermore , Bcl 2 oncoprotein was also upregulated approximately 8 and 11 fold for BaP and DEHP respectively ; meanwhile Bcl xL protein rate did not change . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
HL 60 / Bcl 2 cells displayed a 5 fold increase in Bcl 2 protein compared with empty vector counter parts ( HL 60 / pCEP4 ) but comparable levels of Bax , Mcl 1 , and Bcl xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
This CD 40 potentiated Fas triggered growth inhibition and apoptosis occurs in the presence of CD 40 induced expression of the anti apoptotic proteins Bcl xL and Bcl 2 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl xL overexpression restricts heat induced apoptosis and influences hsp 70 , bcl 2 , and Bax protein levels in FL5 . 12 cells . ^^^ The current study , using control and bcl xL overexpressing IL 3 dependent FL5 . 12 cells , compared the effects of 1 h of acute heat stress ( 42 degrees C ) followed by 1 , 4 , and 8 h recovery ( 37 degrees C ) on hsp 70 , bax , bcl 2 , and bcl xL protein levels and apoptosis . ^^^ Immunoblotting revealed a time dependent increase in hsp 70 protein levels following 1 h of heat stress in control , but not bcl xL overexpressing cells . bcl 2 protein levels were lower in bcl xL overexpressing cells than in controls , but decreased in both cell lines after heat stress . bax protein levels in bcl xL overexpressing cells were decreased approximately 80 % below baseline levels 1 h post heat shock . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 is expressed in a reciprocal manner to its related gene product Bcl XL with the highest levels observed during the early post proliferative stages of osteoblast maturation . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
FL cells express the death suppressor proteins bcl 2 , bcl xL , and mcl 1 ; whereas GC B cells express bcl xL and mcl 1 but also the proapoptotic proteins bax alpha and bad . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Further , there was no apparent correlation of the steady state level of the apoptosis regulating proteins , Bcl 2 , Bcl XL , Bax and Ich 1 , with tumorigenicity of the prostate cells xenografted in nude mice , aggressiveness of tumors grown in nude mice , and induction of apoptosis by 9NC . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
OBJECT : Genes known to be involved in the regulation of apoptosis include members of the bcl 2 gene family , such as inhibitors of apoptosis ( bcl 2 and bcl xl ) and promoters of apoptosis ( bax ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Significantly , Bcl xL and Bcl w , the two closest homologues of Bcl 2 , also bind to Bim and inhibit its activity , but more distant viral homologues , adenovirus E1B19K and Epstein Barr virus BHRF 1 , can do neither . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In addition , Bcl 2 and Bcl xL suppressed PEITC induced apoptosis , but failed to protect cells from death induced by overexpression of activated JNK 1 . ^^^ These results suggest that Bcl 2 and Bcl xL are upstream of JNK . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Many members of the Bcl 2 family , including Bcl XL , are potent inhibitors of programmed cell death and inhibit activation of caspases in cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 , Bcl xL , and Mcl 1 are three related intracellular polypeptides that have been implicated as negative regulators of apoptosis . ^^^ Levels of Bcl 2 , Mcl 1 , Bcl xL , and Bax each varied over a more than 10 fold range in different pretreatment leukemia specimens . ^^^ Approximately equal numbers of samples showed twofold increases and decreases in Bcl 2 ( 5 increases , 3 decreases ) and Bcl xL ( 1 increase , 4 decreases ) at recurrence . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Here , we show that one of the E 4 products , E4orf4 , is highly toxic upon expression in rodent cells regardless of the p 53 status , and that this cytotoxicity is significantly overcome by coexpression with either Bcl 2 or Bcl XL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
CD 40 signaling with anti CD 40 antibody resulted in the induction of Bcl 2 and Bcl XL proteins in WEHI 231 cells . ^^^ Constitutive expression of Bcl 2 but not Bcl XL inhibited concanamycin A induced apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Ectopic expression of Bcl 2 , but not Bcl xL rescues Ramos B cells from Fas mediated apoptosis . ^^^ We have previously shown that protection from calcium ionophore and macromolecular synthesis inhibitor induced apoptosis by CD 40 ligation is associated with a rapid up regulation of Bcl xL followed by a more moderate and delayed up regulation of Bcl 2 . ^^^ We show here that overexpression of Bcl xL , like Bcl 2 , protects Ramos cells from apoptosis induction in response to calcium ionophore , anti Ig and macromolecular synthesis inhibition . ^^^ However , in contrast to Bcl 2 , ectopic overexpression of Bcl xL does not rescue from Fas mediated apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Suppression of apoptosis by overexpression of Bcl 2 or Bcl xL promotes survival and mutagenesis after oxidative damage . ^^^ Bcl 2 , a membrane bound cytoplasmic protein , and its close relative Bcl xL , are both effective inhibitors of apoptosis induced by a wide variety of stimuli in many different cell types . ^^^ In a previous study , we reported that suppression of apoptosis by Bcl 2 or Bcl xL , markedly elevates the levels of radiation induced mutations at the specific locus thymidine kinase . ^^^ We investigated the effect of the Bcl 2 or Bcl xL overproduction on hydrogen peroxide induced mutagenesis . ^^^ Overexpression of either Bcl 2 or Bcl xL enhances oxidative stress mutagenesis in cells with wild type p 53 as well as with mutated p 53 protein . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We also found that the expression of p 53 , p21waf1 / cip1 , Bcl 2 , Bax , Bcl xL , Bad and cyclins D 1 , E , A and B did not show any significant changes following c Myc induction . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We analyzed the expression of genes promoting apoptosis ( fas / fasL1 and bax ) and those inhibiting apoptosis ( bcl 2 and bcl xL ) in lymphocytes from aging and young subjects at the protein level , using flow cytometry / Western blotting , and at the mRNA level , using quantitative PCR . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Furthermore , apoptosis of SL 2 cells that was induced by a Drosophila cell death gene , reaper , was shown to be partially prevented by ced 9 , bcl 2 and bcl xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
While the control HL 60 cells showed high levels of Bcl 2 and barely detectable Bcl xL , HL 60 / Bcr Abl cells expressed high levels of Bcl xL and undetectable levels of Bcl 2 , a pattern of expression similar to the one in K 562 cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The apoptotic population in the cells expressing Bax 112 192 was not decreased by co expression of Bcl 2 or Bcl XL , while Bcl 2 or Bcl XL suppressed apoptosis in the cells expressing native Bax . ^^^ Therefore , Bax induces apoptosis by its own activity without blocking the anti apoptotic activity involved in Bcl 2 or Bcl XL . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
An equivalent ternary complex was found to be present in mammalian cells involving Apaf 1 , the mammalian death protease caspase 9 , and Bcl XL , an anti apoptotic member of the Bcl 2 family . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The expression of the Bcl 2 family proteins Bax , Mcl 1 , Bcl 2 , and Bcl xL , was examined in human peripheral blood eosinophils or in umbilical cord blood derived eosinophils . ^^^ Although cord blood derived eosinophils expressed easily detectable levels of Mcl 1 , Bcl 2 , and Bcl xL , only traces or no expression of these three antiapoptotic proteins were found in peripheral blood eosinophils . ^^^ Incubation of both eosinophil types for 1 to 3 days in a cytokine deprived medium led to apoptosis , without changes in the expression of Bax , Mcl 1 , Bcl 2 , or Bcl xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Upon CD 95 triggering , all mitochondrial apoptogenic activities were blocked by Bcl 2 or Bcl xL overexpression in both cell types . ^^^ However , in type 2 but not type 1 cells , overexpression of Bcl 2 or Bcl xL blocked caspase 8 and caspase 3 activation as well as apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Constitutive expression of Bcl xL or Bcl 2 prevents peptide antigen induced T cell deletion but does not influence T cell homeostasis after a viral infection . ^^^ We examined the CD8+ T cell response to lymphocytic choriomeningitis virus ( LCMV ) in mice doubly transgenic for an LCMV specific TCR and for either bcl xL or bcl 2 . ^^^ Expression of Bcl xL or Bcl 2 did , however , prevent LCMV peptide induced peripheral deletion of mature CD8+ T cells in vivo and apoptosis of activated LCMV specific effector T cells in vitro . ^^^ The CD8+ T cells `` rescued ' ' by Bcl xL or Bcl 2 from peptide antigen induced cell death were anergic and this could not be reversed by addition of IL 2 in vitro or by adoptive transfer into antigen free recipient mice followed by LCMV infection in vivo . ^^^ Taken together , we show here that 1 ) Bcl xL or Bcl 2 are functionally equivalent in their ability to modulate CD8+ T cell survival in vivo , 2 ) distinct apoptosis signaling pathways exist in CD8+ T cells , one that can be inhibited by Bcl 2 or Bcl xL and one that can not be blocked , and 3 ) apoptosis of CD8+ effector T cells during the declining phase of an immune response is not prevented by constitutive expression of the anti apoptotic proteins Bcl xL and Bcl 2 . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 independent Bcr Abl mediated resistance to apoptosis : protection is correlated with up regulation of Bcl xL . ^^^ Interestingly , wild type and mutant Bcr Abl induced in HL 60 cells a dramatic down regulation of Bcl 2 and increased the levels of Bcl xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Blk , a BH 3 containing mouse protein that interacts with Bcl 2 and Bcl xL , is a potent death agonist . ^^^ Blk contains a conserved BH 3 domain and can interact with the anti apoptotic proteins Bcl 2 and Bcl xL . ^^^ Ectopic expression of Blk in mammalian cells induces apoptosis , which can be inhibited by mutations in the BH 3 domain and by overexpression of Bcl 2 or Bcl xL but not by CrmA . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Finally , the results indicate that Akt can transduce a survival signal for differentiating neuronal cells through a mechanism that is independent of induction of Bcl 2 or Bcl XL or inhibition of Jun kinase activity . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Mtd , a novel Bcl 2 family member activates apoptosis in the absence of heterodimerization with Bcl 2 and Bcl XL . ^^^ Unlike all other known death agonists of the Bcl 2 family , Mtd did not bind significantly to the survival promoting proteins Bcl 2 or Bcl XL . ^^^ Furthermore , apoptosis induced by Mtd was not inhibited by Bcl 2 or Bcl XL . ^^^ A Mtd mutant with glutamine substitutions of highly conserved amino acids in the BH 3 domain retained its ability to promote apoptosis , further indicating that Mtd does not promote apoptosis by heterodimerizing with Bcl 2 or Bcl XL . ^^^ Mtd is the first example of a naturally occurring Bcl 2 family member that can activate apoptosis independently of heterodimerization with survival promoting Bcl 2 and Bcl XL . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
OBJECTIVE : To investigate the nuclear localization of the transcription factor NF kappa B , the status of apoptosis and the expression of the Fas antigen , Fas ligand , Bcl 2 , Bcl xL and Bax by synovial cells . ^^^ Interestingly , freshly isolated SF T cells upregulated the expression of Bcl xL as compared to Bcl 2 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The effect of TGF beta 1 and DEX on cellular amounts of several apoptosis related proteins , members of the Bcl 2 family , Bcl 2 , Bcl xL , Bcl xS , Bad , and Bax was also examined . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl XL , an antiapoptotic member of the Bcl 2 family , was shown to physically interact with Apaf 1 and caspase 9 in mammalian cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Although calcium , prooxidants , and several recombinant caspases ( caspases 1 , 2 , 3 , 4 , and 6 ) enhance the permeability of PT pore containing liposomes , recombinant Bcl 2 or Bcl XL augment the resistance of the reconstituted PT pore complex to pore opening . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Signaling targets of Jak kinase pathways included members of the Bcl 2 family of anti apoptotic proteins , and enforced expression of Bcl 2 or Bcl xL was as effective as cytokine treatment in blocking IR induced apoptosis but did not prevent growth arrest . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 , Bcl XL , and Bax are members of the Bcl 2 family that play important roles in apoptosis regulation . ^^^ However , we recently found by subcellular fractionation that whereas Bcl 2 is predominantly a membrane protein as previously reported , Bax and a significant fraction of Bcl XL are soluble in thymocyte and splenocyte extracts . ^^^ Induction of apo ptosis which causes the insertion of the soluble form of Bax into membranes did not result in appreciable Bax / Bcl XL , Bax / Bcl 2 or Bax / Bax dimer formation as determined by cross linking studies . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The expression of several apoptosis regulating proteins , including the Bcl 2 family proteins Bcl 2 , Bcl XL , Mcl 1 , Bax , Bak , and BAD ; the Bcl 2 binding protein BAG 1 ; and the cell death protease Caspase 3 ( CPP 32 ) , was evaluated by immunoblotting using 58 peripheral blood B CLL specimens from previously untreated patients . ^^^ Expression of Bcl 2 , Mcl 1 , BAG 1 , Bax , Bak , and Caspase 3 was commonly found in circulating B CLL cells , whereas the Bcl XL and BAD proteins were not present . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Enhancement of nuclear apoptosis by herbimycin was not attributable to downregulation of the bcl 2 or bcl XL anti apoptotic proteins . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Surface plasmon resonance was used to examine the kinetics of dimerization as a function of pH between the anti apoptotic protein Bcl XL ( applied in the mobile phase ) and three other members of the Bcl 2 family : Bcl 2 , Bax , and Bid ( immobilized on biosensor chips ) . ^^^ Thus , low pH stabilizes homo and heterodimeric complexes comprised of Bcl XL and these other Bcl 2 family proteins . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Antagonist effect of insulin like growth factor 1 on protein kinase inhibitor mediated apoptosis in human glioblastoma cells in association with bcl 2 and bcl xL . ^^^ METHODS : Human glioblastoma cells were treated with or without TAM and / or IGF 1 in vitro and evaluated for : viability by the 3 ( 4 , 5 dimethylthiazol 2 yl ) 2 , 5 diphenol tetrazolium bromide cleavage assay ; apoptosis by histochemical analysis of nuclear morphology and 3 ' OH DNA fragments ; and expression of the IGF 1 receptor , and the bcl 2 , bcl xL , and bax proteins by immunoblot analysis . ^^^ Exogenous IGF 1 stimulated WITG 3 cell proliferation and significantly ( p < 0 . 05 ) antagonized the cytotoxic effects of TAM in a dose dependent fashion ; IGF 1 , but not TAM , enhanced expression of bcl 2 and bcl xL proteins ; however , bax protein expression was unchanged by either treatment . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 and Bcl xL in peroxide resistant A 549 and U87MG cells . ^^^ Overexpression of the bcl 2 and the related bcl xL protooncogene proteins enhance cell survival by inhibiting apoptosis induced by many agents including oxidants . ^^^ The current study assessed the expression of bcl 2 and bcl xL proteins in human glioblastoma U87MG cells and human lung adenocarcinoma A 549 cells selected for resistance to 0 , 50 , 100 , 200 , and 400 microM H2O2 by exposure to this oxidant one time each passage for 9 months . ^^^ Although the increased bcl 2 protein in peroxide resistant U87MG cells may contribute to their oxidant tolerance , the lack of a dose response relationship , the failure to induce bcl xL protein , and the absence of any bcl 2 or bcl xL protein induction in peroxide resistant A 549 cells suggest these genes are not primary factors in oxidant resistance . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Endogenous mRNA and protein levels of Bcl XL , a member the Bcl 2 family which suppresses apoptosis , were specifically inhibited by EGFR blockade . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
There were no changes in levels of Bcl 2 , Bcl XL , or 24 kDa Bax over 72 hr after exposure to cisplatin or paclitaxel , but each agent led to up regulation of Bak and 21 kDa Bax in A 2780 cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Moreover , BCL XL , BCL 2 , and BAX can form ion conductive pores in artificial membranes . ^^^ BCL 2 and BCL XL display a reciprocal pattern of expression during lymphocyte development . ^^^ Gain and loss of function models revealed stage specific roles for BCL 2 and BCL XL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
To search for a Bcl 2 family homologue in the posterior silk gland of Bombyx mori , Western blot analysis was performed with the anti rat Bcl XL antiserum preabsorbed with a XL 1 Blue MRF ' lysate . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Lastly , reverse transcriptase PCR and immunohistologic studies showed a significant reduction in the intragraft expression of key products of T cell and macrophage activation , and upregulation of what have recently been termed as `` protective ' ' genes , including the bcl family members , Bcl 2 and Bcl xL , and hemoxygenase . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The mitochondrial permeability transition ( PT ) pore , also called mitochondrial megachannel or multiple conductance channel , is a multiprotein complex formed at the contact site between the mitochondrial inner and outer membranes , exactly at the same localization at which Bax , Bcl 2 , and Bcl XL are particularly abundant . ^^^ Experiments involving the purified PT pore complex indicate that Bax , Bcl 2 , and Bcl XL exert at least part of their apoptosis regulatory function by facilitating ( Bax ) or inhibiting ( Bcl 2 , Bcl XL ) PT pore opening . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Examination of apoptosis related gene expression by RT PCR showed that bcl 2 expression was greater in 4 pp R than in RVC . p 53 , bax and bcl xL were expressed at the same level in 4 pp R and RVC cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Hyporesponsiveness is not associated with alterations in the thymocyte subset distribution , decreased expression of full length Fas protein , or alterations in FADD , Bcl 2 , or Bcl XL expression . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Recent studies have focused on the role that programmed cell death ( i . e . , apoptosis ) plays in both normal and neoplastic growth : certain genes can either suppress ( e . g . , Bcl 2 , Bcl xL ) or promote ( e . g . , Bik , Bax , Bak ) apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In contrast , cycling B cells restimulated with either soluble F ( ab ' ) 2 or immobilized anti mu expressed heightened levels of the survival protein Bcl xL , and only cells restimulated with immobilized anti mu expressed the survival protein Bcl 2 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Recent studies have demonstrated that the anti apoptotic proteins , Bcl 2 and Bcl xl , with the carboxyl terminal hydrophobic domain removed , form cation selective channels in the lipid bilayer reconstitution system . ^^^ This calcium dependent regulation of the Bcl xl channel provides new insights into the roles of calcium and Bcl 2 related proteins in the programmed cell death pathway . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
On the other hand , the levels of apoptosis inhibiting proteins bcl 2 , bcl xL and BAG 1 increased progressively after immortalization and transformation . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In many tissues the apoptosis related gene products act in cohort : Bcl 2 and Bcl xl promoting survival of a cell , whilst Bax promotes cell death often positively regulated by the tumour suppressor gene p 53 . ^^^ Western blot analysis showed that : ( 1 ) Bcl 2 and p 53 were absent from interstitial Leydig cells but were expressed in the seminiferous tubules . ( 2 ) Bax protein although expressed in the interstitium was not present in the Leydig cells . ( 3 ) Bcl xl in Leydig cells was transiently increased after EDS . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Moreover , BI 1 can interact with Bcl 2 and Bcl XL but Bax or Bak , as demonstrated by in vivo cross linking and coimmunoprecipitation studies . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In this study we have investigated by Western blotting the expression pattern of Bcl 2 and its homologues Bax , Bak , Bcl xL , Bcl xS , Mcl 1 and Bad in 12 distant lymph node metastases from patients who have been treated by different regimes , in nine newly established cell lines of these metastases , in three cell lines obtained from other sources and in primary melanocytic cell lines from three neonatal and two adult subjects . ^^^ Taken together , our data suggest that Bax , Bak , Bad , Bcl xL and Mcl 1 are expressed in addition to Bcl 2 in both normal melanocytes and in cell lines established from melanoma metastases . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In this study , we screened for the expression of bcl 2 homologues ( bcl 2 , bax , bcl xl , and bcl xs ) and Fas ligand ( FasL ) by RT PCR method in grafts during acute rejection in rats following liver transplantation . ^^^ Both bax and bcl xs ( inducers of apoptosis ) mRNA levels increased steadily in the allografted group from postoperative day ( POD ) 2 to 8 , while no remarkable changes of bcl 2 and bcl xl expression ( inhibitors of apoptosis ) were recognized . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We suggest that prolonged survival of accommodated xenografts is due to the expression of the protective genes A 20 , bcl 2 bcl xL , and heme oxygenase 1 in the xenograft endothelium and possibly smooth muscle cells . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In addition , TGF beta transcriptionally regulates Bcl 2 family members , Bcl XL and Bik , to further influence the apoptosis process . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In particular , the content of the antiapoptotic products Bcl 2 and Bcl XL resulted to be increased in treated cells , whereas the expression of the proapoptotic protein Bax remained unaltered . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Western blotting analysis revealed that pre treatment of MDA MB 453 cells with SF inhibited the ADR induced decreases in the levels of Bcl XL , an anti apoptotic protein related to Bcl 2 ; and the dose response and time course characteristics for SF mediated increases in the Bcl XL protein levels of ADR treated cells were consistent with the degrees of protection against apoptosis observed under the same conditions . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
To elucidate the role of Bcl 2 family members in the inhibition of eosinophil apoptosis , we examined the expression of the known anti apoptotic genes Bcl 2 , Bcl xL , and A 1 , as well as Bax and Bcl xS , which promote apoptosis in other systems . ^^^ We show herein that freshly isolated human eosinophils express significant amounts of Bcl xL and Bax , but only little or no Bcl 2 , Bcl xS , or A 1 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Ectopic expression of Bcl 2 or Bcl XL blocked drug induced apoptosis in both cell lines . ^^^ In contrast , whereas Bcl 2 blocked apoptosis in both cell lines in response to IL 3 withdrawal , Bcl XL blocked apoptosis in max overexpressing cells but not in c myc overexpressing cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
PDGF BB treatment reduced bcl 2 mRNA and bcl xl mRNA expression , in contrast , induced bcl xs mRNA expression , linked with the induction of apoptosis in cultured VSMC . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Here , we report that the expression of bcl 2 , bcl xL , bcl xS , bax and bad mRNA as well as of Bcl 2 , Bax , Bcl XL , Bcl XS and Bag 1 proteins is not modulated in these two paradigms of neuronal cell death . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The expression of the contra apoptotic protooncogenes bcl 2 and bcl xl was found to be much stronger in early HSC than in late HSC and MFB as shown by ribonuclease protection assay . ^^^ It is concluded that transformation of HSC to MFB is paralleled by an increasing sensitivity to sFasL mediated apoptosis , which might be related to a strong decrease of bcl 2 and bcl xl expression , leading to a preponderance of proapoptotic gene expression in MFB . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In response to the same antigen , Tg HEL Ig B cells not expressing bcl xL were deleted , while cells expressing bcl 2 were arrested at the immature B stage . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
T cell subsets from a patient with DiGeorge anomaly were examined for the expression of Fas , FasL , Bcl 2 and Bcl XL at the protein level with monoclonal antibodies , using dual colour flow cytometry , and at the mRNA level in mononuclear cells by quantitative reverse transcriptase polymerase chain reaction . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
No changes in protein levels of p 53 , Bcl xl , or Bcl 2 were detected in the cerebral cortex , hippocampus , or striatum at any time point following reperfusion . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Taxol , 1 beta D arabinofuranosylcytosine ( ara C ) , and etoposide induce apoptosis in HL 60 cells that is blocked by overexpression of Bcl 2 or Bcl xL . ^^^ A 60 amino acid `` loop ' ' domain of Bcl 2 and Bcl xL that contains phosphorylation sites is known to negatively regulate their antiapoptotic function . ^^^ This was compared with control HL 60 / neo cells as well as HL 60 / Bcl 2 and HL 60 / Bcl xL cells . ^^^ The latter two cell lines overexpress full length Bcl 2 and Bcl xL , respectively . ^^^ Exposure to etoposide ( 50 microM ) or ara C ( 100 microM ) for 4 h induced apoptosis in HL 60 / neo cells , but not in HL 60 / Bcl 2 , HL 60 / Bcl xL , HL 60 / Bcl 2delta , or HL 60 / Bcl xLdelta cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The Bcl 2 related family member Bcl xL also exhibits a death suppressive activity , but its potential for phosphorylation following exposure to drugs that interact with microtubules has not been evaluated . ^^^ Several tumor cell lines with low or undetectable levels of Bcl 2 protein expression were found to express Bcl xL . ^^^ As observed for Bcl 2 , phosphorylation of Bcl xL was accompanied by phosphorylation of Raf 1 . ^^^ Taken together , these results suggest that Bcl xL , like Bcl 2 , is phosphorylated by agents that disrupt microtubule architecture . ^^^ By analogy with Bcl 2 , this phosphorylation may play a critical role in modulating Bcl xL function and may be an important determinant of microtubule directed chemotherapeutic efficacy in human tumors . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The expression of Bcl 2 , Bcl xl , Bax , p 53 and poly ( ADP ) ribose polymerase ( PARP ) was demonstrated in tissue extracts by Western blotting . ^^^ However , in the long term treated testes , Bcl xl and PARP expression declined , Bax and p 53 protein concentrations were unchanged , and Bcl 2 was up regulated . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Immunochemical analysis revealed that expression of apoptosis related gene products , such as Bcl 2 , Bcl xL and Bax , was below detectable levels with both cell types . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
This in vivo study focused on whether IL 3 rescued noncholinergic hippocampal neurons from lethal ischemic damage by modulating the expression of Bcl xL , a Bcl 2 family protein produced in the mature brain . 7 d IL 3 infusion into the lateral ventricle of gerbils with transient forebrain ischemia prevented significantly hippocampal CA 1 neuron death and ischemia induced learning disability . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The purpose of our study was to ( 1 ) assess the relationship between apoptosis and enterocyte differentiation and ( 2 ) determine whether the cell cycle inhibitors , p21Waf1 / Cip1 and p27Kip1 , or the apoptosis inhibitors , Bcl 2 and Bcl XL , may be involved . ^^^ Increased levels of p21Waf1 / Cip1 and p27Kip1 mRNA and protein were detected at 24 hours , occurring before apoptosis or differentiation ; decreased mRNA levels of Bcl 2 and Bcl XL were noted at 24 hours . ^^^ The induction of p21Waf1 / Cip1 and p27Kip1 and the down regulation of Bcl 2 and Bcl XL further suggest a link between the cell cycle mechanisms regulating enterocyte differentiation and apoptosis . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Cytoprotective Bcl 2 family proteins such as Bcl 2 and Bcl XL prevent mitochondrial permeability transition pore opening and release of apoptogenic proteins from mitochondria under many circumstances that would otherwise result in either apoptosis or necrosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 family proteins are key regulators of apoptosis and function as cell death antagonists ( e . g . , Bcl 2 , Bcl XL , and Mcl 1 ) or agonists ( e . g . , Bax , Bad , and Bak ) . ^^^ Here we report that among the Bcl 2 family of proteins tested ( Bcl 2 , Bcl XL , Mcl 1 , Bax , Bad , and Bak ) , Bcl XL was unique in that its protein levels were tightly regulated by hemopoietins in both immortal and primary myeloid progenitors . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl xS and Bad potentiate the death suppressing activities of Bcl xL , Bcl 2 , and A 1 in yeast . ^^^ In yeast , Bax is lethal , and this activity is suppressed by Bcl xL , Bcl 2 , and A 1 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In the yeast cell assay , BOD interacts with diverse antiapoptotic Bcl 2 proteins [ Mcl 1 , Bcl 2 , Bcl xL , Bcl w , Bfl 1 , and Epstein Barr virus ( EBV ) BHRF 1 ] but not with different proapoptotic Bcl 2 proteins ( BAD , Bak , Bok , and Bax ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
This analysis revealed that several genes whose products have anti apoptotic activity , including bcl 2 , bcl xL , hsp 70 , grp 78 and the glutathione S transferases , are expressed as early as the stage 1 embryo in the newly oviposited egg . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
CED 4 directly interacts with the Bcl 2 homologue CED 9 ( or the mammalian Bcl 2 family member Bcl xL ) and the caspase CED 3 ( or the mammalian caspases ICE and FLICE ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Our BAX deletion constructs and minimal domain constructs indicated that the BH 3 domain was required for BAX homodimerization and heterodimerization with BCL 2 , BCL XL , and MCL 1 . ^^^ This suggests that BAX ' s killing function reflects mechanisms beyond its binding to BCL 2 or BCL XL to inhibit them or simply displace other protein partners . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bleomycin induced apoptosis was accompanied by decreases in bcl 2 and bcl xl and increases in p 53 , bak , and bax protein levels . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Third , opening of the purified megachannel reconstituted into liposomes is inhibited by recombinant Bcl 2 or Bcl XL , two apoptosis inhibitory proteins which also prevent megachannel opening in cells and isolated mitochondria . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We provide data to show that this resistance is not dependent on monolayer morphology , constant engagement of the CD 44 receptor , loss of the 23C6 antigen , or elevation of Bcl 2 or Bcl XL protein . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Moreover , the expression of Bcl 2 and Bcl xL , apoptosis suppressive proteins , is reduced in dominant negative STAT 3 transfected cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The pathways leading to apoptosis following treatment with TNF + CHX and TNF + cer are different since only TNF + CHX is blocked by the caspase inhibitors crmA protein or the peptide zVAD . fmk while only TNF + cer is blocked by the anti apoptotic proteins Bcl 2 , Bcl XL or Al . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
When the activation of caspases was suppressed by overexpressing human Bcl 2 protein or by the addition of caspase inhibitors , cleavage of Bcl XL protein was suppressed in vivo . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
A dose and time response study revealed that 5 nmol of MK886 / 10 ( 6 ) cells was sufficient to induce apoptosis both in control and bcl xL cells , respectively , but to different degrees . bcl xL and bcl 2 proteins , but not bax or FLAP , were decreased by 4 h after 5 nmol of MK886 / 10 ( 6 ) cells in both cell lines , although the higher levels of bcl xL in overexpressors took longer to disappear . ^^^ This early loss of bcl xL and bcl 2 was not attributable to generalized proteolysis , as shown by Coomassie Blue staining and by the maintenance of bax . ^^^ The absence of 5 lipoxygenase in cells containing FLAP , the lower level of FLAP in bcl xL cells , the apoptosis inducing activity of MK 886 , and the rapid loss of bcl xL and bcl 2 proteins after treatment with MK 886 strongly indicate that FLAP has activities unrelated to lipoxygenase and suggest a possible functional or regulatory link between these proteins , which share similar subcellular localizations . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In cells overexpressing either Bcl 2 or Bcl xL , transient overexpression of Apaf 1 did not induce apoptosis . ^^^ This increase in paclitaxel or etoposide induced apoptosis of HL 60 / Apaf 1 cells was not associated with any significant alterations in Bcl 2 , Bcl xL , Bax , Fas , or Fas ligand expression . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
CONCLUSIONS : The results of these studies indicate that Bcl xL is expressed in ovarian carcinoma , and in A 2780 cells functions in a manner analogous to Bcl 2 by inhibiting chemotherapy induced apoptosis . ^^^ In ovarian carcinoma , another Bcl 2 family member , Bcl xL may be responsible for modulating resistance to chemotherapy induced apoptosis . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The proteins evaluated were p 53 and six members of the Bax / Bcl 2 family : three proapoptotic proteins ( Bax , Bak , and Bcl xS ) and three survival factors ( Bcl 2 , Bcl xL , and Mcl 1 ) . ^^^ In addition , expression levels of Bcl 2 , Bcl xL , Bcl xS , Bak , or Mcl 1 did not correlate with sensitivity or resistance to the four drugs . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
This was associated with downregulation of the antiapoptotic Bcl xL and Bcl 2 proteins , whereas viable NHL TIL maintained their expression . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
When constitutively expressing bcl 2 , but not its closest homolog , bcl XL , following a primary lytic infection , approximately 5 to 10 % of BHK 21 and CHO cells became persistently JEV infected during a long term culture . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
RT PCR shows that in REHIPs , Abeta decreases mRNA expression of Bcl 2 , as well as the ratio of Bcl xL / Bcl xS , with little effect on Bax expression . ^^^ When REHIPs are incubated with TGF beta before addition of Abeta , the Bcl xL / Bcl xS ratio and Bcl 2 levels are increased compared to cells treated with Abeta alone . ^^^ Western blotting and immunohistochemistry experiments also show that TGF beta maintains increased levels of Bcl 2 and Bcl xL protein in REHIPs even in the presence of Abeta . ^^^ Similarly , RT PCR analysis of mRNA prepared from hNT cells shows that TGF beta pretreatment before addition of Abeta maintains a higher level of Bcl 2 expression and an increased Bcl xL / Bcl xS ratio as compared to cells treated with Abeta alone . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Taxol and estramustine induced modulation of human prostate cancer cell apoptosis via alteration in bcl xL and bak expression . bcl xL is an antiapoptotic protein that shares sequence homology with bcl 2 and seems to convey chemoresistance in many human tumor cell lines . bcl xL protein is expressed at a 3 fold higher level in PC 3 cells than it is in LNCaP cells . ^^^ Treatment of LNCaP cells with 10 nm Taxol led , after 24 h , to relatively specific and almost total down regulation of bcl xL protein in the absence of alteration of bax , bak , or bcl 2 levels . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Overexpression of HER 2 modulates bcl 2 , bcl XL , and tamoxifen induced apoptosis in human MCF 7 breast cancer cells . ^^^ We report that HER 2 overexpression in MCF 7 cells is accompanied by up regulation of antiapoptotic Bcl 2 and Bcl XL proteins and suppression of tamoxifen induced apoptosis . ^^^ Our findings suggest that possible deregulation of antiapoptotic Bcl 2 and Bcl XL may be associated with the enhanced survival of HER 2 overexpressing and ER positive breast cancer cells treated with antiestrogens . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The expression levels of Bcl 2 , Bax , and Bcl XL were not changed following the co treatment with inostamycin plus paclitaxel , whereas the activated form of caspase 3 was markedly increased . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Results from Western blot analysis indicate that WSU CLL cells express high levels of Bcl 2 , Bcl xL and c myc , and a low level of Bax . p 53 in untreated WSU CLL cells is undetectable . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Consistent with this , Diva did not bind to cellular Bcl 2 family members including Bcl 2 , Bcl XL , Bcl w , Mcl 1 , and A1 / Bfl 1 . ^^^ Thus , Diva represents a novel type of proapoptotic Bcl 2 homologue that promotes apoptosis independently of the BH 3 region through direct binding to Apaf 1 , thus preventing Bcl XL from binding to the caspase 9 regulator Apaf 1 . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
IL 7 prevented the decrease in Bcl 2 and Bcl xL and induced cell cycling in up to 20 % of cord T cells after 8 days , resulting in a threefold increase in cord T cell numbers . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Furthermore , TIMP 1 upregulation induced expression of Bcl XL but not Bcl 2 as well as decreased NF kappaB activity as compared with controls . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Specifically , hyaluronidase upregulated p 53 protein expression ( > 200 % ) but down regulated a p 85 inter alpha inhibitor like protein ( > 90 % ) in L 929 cells , whereas it had no effect on the protein levels of ICH 1 , Bcl xL , Bcl 2 , Fas ligand , CAS ( cellular apoptosis susceptible protein ) , TIAR ( an RNA binding protein ) and alpha tubulin . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Distinct sites of action of Bcl 2 and Bcl xL in the ceramide pathway of apoptosis . ^^^ We studied the inhibition of tumour necrosis factor alpha ( TNFalpha ) and camptothecin induced apoptosis by Bcl 2 and Bcl xL as they relate to the ceramide pathway . ^^^ Expression of either Bcl 2 or Bcl xL provided significant protection from the apoptotic effects of TNFalpha or camptothecin . ^^^ In contrast to Bcl 2 , Bcl xL overexpression did not protect cells from ceramide induced apoptosis . ^^^ On the other hand , Bcl xL prevented the accumulation of endogenous ceramide in response to TNFalpha or camptothecin , whereas Bcl 2 showed little effect on ceramide formation . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bax induced mitochondrial changes were inhibited by recombinant Bcl xL and transgene derived Bcl 2 , antiapoptotic members of the Bcl 2 family , as well as by oligomycin , suggesting a possible regulatory effect of F0F1 ATPase on Bax induced mitochondrial changes . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Overexpression of bcl 2 or bcl XL fails to inhibit apoptosis mediated by a novel retinoid . ^^^ Overexpression of bcl 2 or bcl XL has been found to inhibit the induction of apoptosis in malignant cells by a large number of agents including a wide variety of chemotherapeutic drugs . ^^^ The addition of 1 microM CD 437 to HL 60 / NEO cells resulted in capase 3 ( CPP 32 ) activation and poly ( ADP ribose ) polymerase ( PARP ) cleavage in 3 h whereas in bcl 2 or bcl XL overexpressing HL 60 cells CD 437 induced CPP 32 activation and PARP cleavage in 6 h . ^^^ Although 50 and 300 nM CD 437 were required to induce PARP cleavage in HL 60 / NEO and HL 60 / bcl 2 , HL 60 / bcl XL cells , respectively , maximal apoptosis in both cell lines was achieved utilizing 300 nM CD 437 . ^^^ In addition , CD 437 induces GI arrest as well as p21WAFI / CIPI mRNA expression in these cells despite the overexpression of bcl 2 or bcl XL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Regulation of B cell apoptosis by Bcl 2 and Bcl XL and its role in the development of autoimmune diseases ( Review ) . ^^^ Bcl 2 and Bcl XL , two members of the bcl 2 gene family of programmed cell death regulators with anti apoptotic activity , are expressed in a highly regulated pattern during B cell maturation . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
TNF alpha and IFN gamma render microglia sensitive to Fas ligand induced apoptosis by induction of Fas expression and down regulation of Bcl 2 and Bcl xL . ^^^ The effect of these cytokines was paralleled by up regulation of Fas expression and down regulation of Bcl 2 and Bcl xL but not Bax . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Overexpression of Bcl 2 and Bcl XL conferred resistance to BA at the level of mitochondrial dysfunction , protease activation , and nuclear fragmentation . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Nix can overcome the suppressers Bcl 2 and Bcl XL , although high levels of Bcl XL expression will inhibit apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Caspase cleaved BID targets mitochondria and is required for cytochrome c release , while BCL XL prevents this release but not tumor necrosis factor R1 / Fas death . `` BH 3 domain only ' ' members of the BCL 2 family including the pro apoptotic molecule BID represent candidates to connect with proximal signal transduction . ^^^ In the presence of BCL XL / BCL 2 , TNFalpha still induced BID cleavage and p 15 BID became an integral mitochondrial membrane protein . ^^^ However , BCL XL / BCL 2 prevented the release of cytochrome c , yet other aspects of mitochondrial dysfunction still transpired and cells died nonetheless . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Overexpression of Bcl 2 and Bcl XL suppressed caspase activation , mitochondrial cytochrome c release , Deltapsi suppression , and apoptosis and cell death induced by GraB , GraK , or perforin . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Overexpression of HA Bax but not Bcl 2 or Bcl XL attenuates 6 hydroxydopamine induced neuronal apoptosis . ^^^ In contrast , overexpression of a well known cell death inhibiting protein such as Bcl 2 or Bcl XL did not attenuate 6 OHDA induced cell death . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Apoptosis inhibiting factor Bcl xL might be the crucial member of the Bcl 2 gene family in colorectal cancer . ^^^ Since the role of the Bcl 2 gene family has been only poorly investigated in colorectal cancer , we have examined the expression of the apoptosis blockers Bcl xL and Bcl 2 , as well as the proapoptotic factors Bax and Bak . ^^^ Of these members of the Bcl 2 gene family , Bcl xL seems to play a major role in colorectal tumorigenesis and disease progression . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Expression of Bcl XS alters cytokinetics and decreases clonogenic survival in K 12 rat colon carcinoma cells . bcl XS , a member of the bcl 2 family , has been shown to induce and / or sensitize some cells to undergo programmed cell death , and to negate the anti apoptotic activity of bcl XL and bcl 2 by mechanisms which are still uncertain . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Hypothesizing that loss of basal cells in oral lichen planus is due to apoptosis , we evaluated LP specimens for apoptosis regulating proteins [ positive regulators Bcl xS , Bax , Fas / Fas ligand , p 53 , and negative regulators ( anti apoptotic ) Bcl 2 , Bcl xL and compared results with reactions in normal mucosa and chronically inflamed gingiva . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The Baxepsilon protein , when expressed as a GST fusion protein , associated efficiently with Baxalpha , Baxepsilon , Bcl 2 , and Bcl xL . ^^^ Furthermore , the presence of antiapoptotic genes including Bcl 2 , Bcl xL , and baculovirus p 35 abrogated Baxepsilon and Baxalpha function . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl xL and Bcl 2 expression in squamous cell carcinoma of the head and neck . ^^^ The authors examined the expression of two related apoptotic inhibitors , Bcl 2 and Bcl xL , in pretreatment biopsies from a series of 42 patients with squamous cell carcinoma of the head and neck . ^^^ METHODS : Formalin fixed , paraffin embedded tumor biopsies from 42 patients with locally advanced squamous cell carcinoma of the head and neck were analyzed by immunohistochemistry using antibodies specific for Bcl xL , Bcl 2 , and p 53 . ^^^ RESULTS : The majority of the tumors demonstrated enhanced expression of either Bcl 2 or Bcl xL compared with surrounding normal epithelium . ^^^ Fifty two percent of the tumors had up regulated Bcl xL , and 17 % had up regulated Bcl 2 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
During this process , IL 6 downregulated expression of BCL 2 in 1A9 M cells and stimulated BCL XL expression , but had no effect on p 53 , Bax , or Bak gene expression . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Cellular protein BNIP 3 is a BCL 2 family proapoptotic protein that interacts with viral antiapoptosis proteins such as adenoviruses E1B 19K and EBV BHRF 1 and cellular antiapoptosis proteins such as BCL 2 and BCL xL . ^^^ BNIP3alpha interacts with viral antiapoptosis protein E1B 19K and cellular antiapoptosis proteins BCL 2 and BCL xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In comparison with A 1 , Bcl 2 was expressed at low levels and was up regulated by monocytes only at 21 h , while neither Bax nor Bcl xL levels were altered by monocytes . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
At 10 9 M to 10 7 M , LPA and S1P significantly suppressed cellular levels of the apoptosis promoting protein Bax , without altering the levels of Bcl xL or Bcl 2 assessed by Western blots and immunoassays . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
There was no correlation between the susceptibility to gemcitabine and the endogenous expression of the B cell lymphoma 2 ( BCL 2 ) family proteins BCL 2 , BCL XL , myeloid cell leukemia 1 ( MCL 1 ) , BCL 2 associated 10 protein ( BAX ) , BCL 2 homologous antagonist / killer ( BAK ) and BCL XS . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Whereas Fas ligand / Fas and tumor necrosis factor ( TNF ) alpha / TNF receptor 1 levels were not altered by NOS 2 deficiency , transcript levels for p 53 were significantly lower in grafts from NOS 2 / recipients , coinciding with a significant increase in the antiapoptotic Bcl 2 / Bax balance and decrease in Bcl Xl levels . ^^^ When NOS 2 is present , p 53 might control NOS 2 mediated apoptosis by stimulating Bax and repressing Bcl 2 and Bcl Xl expression , which may activate the cell death program in the rejecting heart . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The anti apoptotic members of this family , such as Bcl 2 and Bcl XL , prevent apoptosis either by sequestering proforms of death driving cysteine proteases called caspases ( a complex called the apoptosome ) or by preventing the release of mitochondrial apoptogenic factors such as cytochrome c and AIF ( apoptosis inducing factor ) into the cytoplasm . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The anti apoptotic members Bcl 2 and Bcl xL may also control caspase activation independently of cytochrome c relocalisation or may inhibit a positive feedback mechanism [ 4 ] [ 5 ] [ 6 ] [ 7 ] . ^^^ We found that Bcl 2 and Bcl xL set a threshold in the amount of cytochrome c required to activate caspases , even in soluble extracts lacking mitochondria . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 and Bcl XL serve an anti inflammatory function in endothelial cells through inhibition of NF kappaB . ^^^ Overexpression of Bcl 2 or Bcl XL protects EC from tumor necrosis factor ( TNF ) mediated apoptosis . ^^^ In addition , Bcl 2 or Bcl XL inhibits activation of NF kappaB and thus upregulation of proinflammatory genes . ^^^ These data suggest that Bcl 2 and Bcl XL belong to a cytoprotective response that counteracts proapoptotic and proinflammatory insults and restores the physiological anti inflammatory phenotype to the EC . ^^^ By inhibiting NF kappaB without sensitizing the cells ( as with IkappaBalpha ) to TNF mediated apoptosis , Bcl 2 and Bcl XL are prime candidates for genetic engineering of EC in pathological conditions where EC loss and unfettered activation are undesirable . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
However , both Bcl 2 and Bcl xL were weakly detected in lymphocytes from the lesions , compared with those from peripheral blood , suggesting that these cells are susceptible to apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Calphostin C induced apoptosis was associated with synchronous down regulation of Bcl 2 and Bcl xL as well as activation of caspase 3 but not caspase 1 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
By using this system , expression of cell survival genes such as Bcl 2 and Bcl XL was found to enhance erythroid colony formation from colony forming unit erythroid ( CFU E ) in response to EPO . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Furthermore , several binding assays demonstrated that Bcl XL , an anti apoptotic member of the Bcl 2 family , can bind to the oligomeric form of Bax without requiring Bax to dissociate to monomers . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
To address the role of regulatory proteins in RV induced apoptosis , the antiapoptotic gene Bcl 2 or Bcl XL was transfected into RK 13 cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The fivefold elevation in steady state Bcl 2 concentration is not accompanied by detectable changes in the levels or cellular distributions of the related anti apoptotic regulator Bcl xL or of the proapoptotic regulators Bax and Bak and does not produce detectable effects on basal proliferation , differentiation , or death programs . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Cytofluorographic analysis and RT PCR reveal that MEC 1 and MEC 2 overexpress Bcl 2 together with Bax , express large amounts of Bcl xL and trace amounts of Bcl xS . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
To confirm that DP 5 interacts with members of the Bcl 2 family , 293T cells were transiently co transfected with DP 5 and Bcl xl cDNA constructs , and immunoprecipitation was carried out . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Exposure of endothelial cells to hypoxia did not alter levels of proapoptotic and antiapoptotic Bcl 2 family members Bax and Bcl XL by immunoblot analysis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl xL , a member of the Bcl 2 family , inhibits apoptosis , and its expression is regulated at the transcriptional level , yet nothing is known about the transcription factors specifically activating this promoter . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We sought to examine the effect of antiapoptotic gene expression on HIV replication by transfecting the promyelomonocytic cell line U 937 with the bcl xl gene to obtain clones of U 937 cells that overexpressed bcl xl ( designated U937bcl xl ) , a negative control U 937 clone transfected with vector alone ( designated U937neo ) and a clone overexpressing bcl 2 ( designated U937bcl 2 ) . ^^^ Transient coexpression of bcl 2 or bcl xl decreased HIV production and transcription from the HIV LTR . ^^^ To define the mechanism by which bcl xl , but not bcl 2 , inhibits HIV expression , we examined bcl 2 and bcl xl expression after HIV infection and CD 4 cross linking . ^^^ Although HIV 1 infection or cross linking CD 4 led to a decrease in expression of bcl 2 , it had no effect on bcl xl expression . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
However , there was no difference between the two cell lines in the expression of Bcl 2 family proteins Bcl 2 , Bcl XL , Bcl XS , Bad , and Bax at the whole cell level , as analyzed by Western blotting . ^^^ Bcl 2 mainly located to mitochondria and light membrane as a membrane bound protein , whereas Bcl XL was located in both mitochondria and cytosol . ^^^ Similar levels of both Bcl 2 and Bcl XL were present in the resting mitochondria of the two cell lines . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In addition , the expression of MCL 1 , an antiapoptotic member of the BCL 2 family , is downregulated during Na Sal induced cell death , whereas the expression of BCL 2 , BAX , and BCL XL is unchanged . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Interferon alpha and beta promote the reversion of blast Tcells to a resting G0 / G1 configuration with all the characteristic features of stromal cell rescue ; such as high Bcl XL expression and low Bcl 2 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Thus , both protective factors ( e . g . , Bcl 2 and Bcl xL ) and factors that promote hepatocyte death by apoptosis ( e . g . , Bax ) or necrosis ( e . g . , UCP 2 ) may be increased in fatty livers . ^^^ Immunohistochemistry showed striking induction of hepatocyte proteins that promote ( e . g . , Bax ) and inhibit ( e . g . , Bcl 2 and Bcl xL ) apoptosis in both groups with fatty liver . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
It was found that VD 3 significantly induced the expression of Bcl 2 messenger RNA and protein in thyrocytes but had no effect on the expression of Bcl xl and Bax . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Calcineurin was found to dephosphorylate BAD , a pro apoptotic member of the Bcl 2 family , thus enhancing BAD heterodimerization with Bcl xL and promoting apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Furthermore , the antiapoptotic Bcl 2 and Bcl XL proteins can protect yeast against Bax mediated lethality , suggesting that the death regulatory functions of these Bcl 2 family proteins are well preserved in yeast . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Coexpression of Q 79 with the caspase inhibitor CrmA , a dominant negative mutant of FADD ( FADD DN ) , Bcl 2 , or Bcl xL , but not an N terminally tagged Bcl xL , prevented the recruitment of caspase 8 and inhibited polyglutamine induced cell death . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The three dimensional structure of the Bcl 2 homolog , Bcl XL , bears a strong resemblance to some pore forming bacterial toxins . ^^^ This review summarizes the recent initial studies on the in vitro channel activity of Bcl 2 , Bcl XL and Bax and offers some speculation as to the physiological role that these channels may play in the cell death pathway . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Sodium butyrate does not increase Fas receptor cell surface expression and does not modify cell levels of Bcl 2 , Bcl xL , Bcl xS and Bax . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We show that B cell Ag receptor signaling in the absence of coreceptor recruitment induces cellular accumulation of the anti apoptotic protein Bcl xL , whereas CD 19 mediated signals are required for Bcl 2 accumulation . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Moreover , addition of endostatin led to a marked reduction of the Bcl 2 and Bcl XL anti apoptotic protein , whereas Bax protein levels were unaffected . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We examined the expression of the bcl 2 family oncoproteins bax , bak , bcl 2 , bcl xL , and mcl 1 in the course of differentiation of human keratinocytes cultured at low ( 0 . 15 mM ) and high ( 1 . 87 mM ) calcium concentrations . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We have examined , in situ , the influence of Bcl 2 over expression on the messenger RNA level of two pro apoptotic , bax and cpp 32 , and one anti apoptotic , bcl xl , regulators of neuronal death . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In human PMN freshly isolated from the circulation , expression of bcl Xl , bax alpha , and bak , members of the bcl 2 family of apoptosis associated genes , was found using the reverse transcription polymerase chain reaction technique . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Using in vitro protein protein interaction assays , all BNIP 1 variants were shown to interact with BCL 2 and also with BCL2L1 ( previously Bcl xL ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Western blotting analysis showed that sequential treatment ( MALD / TPA ) increased Bcl 2 oncoprotein expression , whereas Bcl XL and Bax proteins were not changed . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
A point mutation within the BH 3 peptide that blocks its ability to bind to Bcl xL abolished its apoptotic activity , suggesting that interaction of the BH 3 peptide with Bcl 2 related death suppressors , such as Bcl xL , may be critical for its activity in cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The Bcl 2 family members Bcl 2 and Bcl xL suppress programmed cell death , whereas Bax promotes programmed cell death . ^^^ An increase in Bcl 2 but not Bcl xL or Bax , cleavage of caspase 1 , up regulation and cleavage of caspase 3 , and evidence for DNA fragmentation with both apoptotic and necrotic morphologies were found in tissue from traumatic brain injury patients compared with controls . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We report that 1 ) the mature DN T cells are highly resistant to TCR cross linking induced apoptosis in the presence of exogenous IL 4 ; 2 ) Fas / Fas ligand and TNF alpha / TNFR pathways do not play an apparent role in regulating apoptosis in DN T cells ; 3 ) the DN T cells constitutively express a high level of Bcl xL , but not Bcl 2 ; 4 ) both Bcl xL and Bcl 2 are up regulated following TCR cross linking ; and 5 ) IL 4 stimulation significantly up regulates Bcl xL and c Jun expression and leads to mitogen activated protein kinase phosphorylation in DN T cells , which may contribute to the resistance to apoptosis in these T cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Mediated by GAPDH binding , DES increases mitochondrial BCL 2 and BCL xL levels and decreases BAX levels thereby preventing the permeability transition pore ( PTP ) form opening and preventing apoptotic degradation . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
These data suggest that the acquisition of IFN gamma mediated autocrine survival signals , other than Bcl 2 or BCL XL , might be important for the development of EBV infected NK leukemia . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
PyF 111 cells were chosen because they hyperexpress PKC delta and they are hypersusceptible to apoptosis because they do not express the antiapoptotic proteins Bcl 2 and Bcl XL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Using RT PCR it was shown that mRNA for several modulators of apoptosis ( Fas , Bcl 2 , Bcl xl , Bax , and ICE ) are expressed by both cell lines and ex vivo tissues . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
A novel protein , Btf ( Bcl 2 associated transcription factor ) , that interacts with E1B 19K as well as with the antiapoptotic family members Bcl 2 and Bcl xL but not with the proapoptotic protein Bax was identified . btf is a widely expressed gene that encodes a protein with homology to the basic zipper ( bZip ) and Myb DNA binding domains . ^^^ E1B 19K , Bcl 2 , and Bcl xL sequester Btf in the cytoplasm and block its transcriptional repression activity . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In contrast , the antiapoptotic protein Bcl 2 is decreased in the mitochondrial enriched membrane compartment of vulnerable regions in ALS , but is increased in the cytosol , whereas Bcl xL levels are unchanged in both subcellular compartments . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Using in situ hybridization , we have studied the kinetics of expression of cpp 32 , bax and bcl xl mRNAs after a fatal lesion of the facial nerve in wild type and Bcl 2 transgenic mice , where cell death is known to be prevented . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The beta 2 adrenoceptor agonist clenbuterol modulates Bcl 2 , Bcl xl and Bax protein expression following transient forebrain ischemia . ^^^ Bcl 2 , Bax and Bcl xl proteins were detectable in the non ischemic hippocampus and the striatum . ^^^ Bcl 2 was up regulated in both detected regions at 24 h after ischemia , while the increase in Bax and Bcl xl protein expression had appeared already at 6 h and also 24 h after ischemia . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
There was no evidence showing that changes in the expressions of Bcl 2 , Bcl xL , Bak , and Bax lead directly to IFN alpha mediated apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 and prevented by Bcl xL . ^^^ We show that , unlike other members of the TNFR family , p75NTR signals death through a unique caspase dependent death pathway that does not involve the `` death domain ' ' and is differentially regulated by Bcl 2 family members : the anti apoptotic molecule Bcl 2 both promoted , and was required for , p75NTR killing , whereas killing was inhibited by its homologue Bcl xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Instead , IFN alpha and IFN beta , but not IFN gamma , significantly increase the levels of the survival protein Bcl 2 , and to a lesser extent , Bcl xL expression . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Western blot analysis for Bcl 2 family of proteins showed that Bax was expressed at a 2 . 2 times lower level in 11ad cells than in KHM 11 cells while there was no difference in expression of Bcl 2 , Bcl Xs nor Bcl XL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
METHODS : Primary bovine glomerular endothelial cells were stimulated with TNF alpha or LPS , and apoptotic cell death was investigated by DNA fragmentation analysis , morphological studies , measurement of cytochrome c efflux and mitochondrial permeability transition , Bak , Bad , Bax , Bcl 2 , Bcl xL protein expression , and caspase 3 like protease activity . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Recent results from our laboratory have indicated that ischaemia induced acute renal failure is associated with up regulation of two anti apoptotic Bcl 2 proteins ( Bcl 2 and Bcl XL ) in the damaged distal tubule and occasional up regulation of Bax in the proximal tubule . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
During the induction of apoptosis by phloretin , the expression of Bax protein in B 16 cells increased and the levels of p 53 , Bcl 2 , and Bcl XL proteins did not change . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In addition , Bcl 2 also prevented the increase in cellular levels of Bak , Bax and Bcl xL , along with degradation of actin and Bax . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Co treatment did not significantly alter Bcl 2 , Bcl xL , Bax or Fas receptor ( FasR ) , but modestly increased Fas ligand ( FasL ) protein . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The anti cancer drug taxol is known to bind to and induce the polymerization of tubulin and has recently been shown to bind to the anti apoptotic protein Bcl 2 , but not to its homolog , Bcl XL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Here we report that in erythroid cells , GATA 1 strongly induces the expression of the anti apoptotic protein bcl xL , but not the related proteins bcl 2 and mcl 1 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Exposure of undifferentiated U 937 cells to 50 microM etoposide for 6 h , that triggers apoptosis in 80 % cells , activates procaspase 2L , 3 and 8 , induces the mitochondrial release of cytochrome c and decreases Mcl 1 expression without modifying Bcl 2 , Bcl xL and Bax protein levels . ^^^ Exposure of TPA differentiated U 937 cells to 0 . 8 microg / ml cycloheximide for 24 h , that triggers apoptosis in 50 % cells , activates procaspase 2L , 3 and 8 , induces the mitochondrial release of cytochrome c and decreases Bcl xL expression without modifying Bcl 2 , Mcl 1 and Bax protein levels . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Phosphorylated Bad , an apoptotic member of the Bcl 2 family , can not bind to Bcl xL and results in Bcl xL homodimer formation and subsequent antiapoptotic activity . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Herein , we demonstrate that diacylglycerol kinase inhibition has a profound effect on the induction of the protooncogenes c myc , c fos , and c raf by IL 2 , whereas expression of bcl 2 and bcl xL are not affected . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Overexpression of the anti apoptotic bcl xL transcript and the pro apoptotic bax mRNA was also detected but no alterations in bcl 2 or bag 1 mRNA levels were observed . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Neuron specific transgene expression of Bcl XL but not Bcl 2 genes reduced lesion size after permanent middle cerebral artery occlusion in mice . ^^^ Protective effects after focal cerebral ischemia were assessed in transgenic mice that overexpress in a neuron specific fashion mouse Bcl XL or human Bcl 2 . ^^^ These findings suggest a selective protective advantage of Bcl XL as compared with Bcl 2 in this mouse model for human stroke . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The aim of the present study is to clarify ( 1 ) whether cardiac apoptosis occurs during the transition from compensated hypertrophy to decompensated heart failure , and ( 2 ) whether expression of the genes encoding Bax ( an apoptosis inducer ) and Bcl xL and Bcl 2 ( apoptosis inhibitors ) is altered during this transition . ^^^ The expression of bcl 2 , bcl xL and bax was analysed by Northern blotting . ^^^ However , there was increased expression of bcl xL in the failing stage , whereas the expression of bcl 2 remained unchanged . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The expression of bcl 2 and bcl XL proteins , which are known to increase cell survival mediated by IL 2 , as well as of p21waf1 and p 53 , was not substantially different in immortalized and transformed cells following IR . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Immunohistochemical analyses were performed on paraffin embedded tissue sections for expression of CD 20 , CD45RO , betaF 1 , CD 68 , CD 44 , kappa and A immunoglobulin light chains , and bcl XL ( a member of the bcl 2 family of proteins involved in apoptosis ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Moreover , we found that this effect is mediated in the absence of changes in expression of Bcl 2 , Bcl Xl , and the pro apoptotic protein Bax . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Accommodating first and second hearts but not rejected second naive hearts expressed high levels of the protective genes A 20 , heme oxygenase 1 ( HO 1 ) , bcl 2 , and bcl xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Expression of p 53 ( a tumor suppressor ) , p21Waf1 and p27Kip1 ( cell cycle inhibitors ) , and Bcl 2 and Bcl XL ( antiapoptotic proteins ) was determined . ^^^ Moreover , CPT treatment resulted in induction of p 53 , p21Waf1 , and p27Kip1 and a decrease in Bcl 2 and Bcl XL RNA and protein levels . ^^^ CONCLUSIONS : Treatment with CPT effectively inhibited the growth of the human gastric cancer SIIA ; the mechanism involved was induction of apoptosis mediated by up regulation of p 53 , p21Waf1 / Cip1 , and p27Kip1 and the down regulation of Bcl 2 and Bcl XL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Early release of mitochondrial cytochrome c and expression of mitochondrial epitope 7A6 with a porphyrin derived photosensitizer : Bcl 2 and Bcl xL overexpression do not prevent early mitochondrial events but still depress caspase activity . ^^^ Enforced overexpression of Bcl 2 or Bcl xL prevented cytochrome c release and 7A6 expression produced by ultraviolet B light treatment , but did not prevent cytochrome c release or 7A6 expression elicited by verteporfin photosensitization . ^^^ Bcl 2 or Bcl xL overexpression delayed morphologic changes , depressed caspase activation , and limited substrate degradation , but did not protect against loss of viability after verteporfin photosensitization . ^^^ This observation indicates that cells overexpressing Bcl 2 or Bcl xL exhibit resistance to caspase activation even after the appearance of cytochrome c in the cytosol . ^^^ Porphyrin photosensitizers are effective chemotherapeutic agents that elicit primary proapoptotic mitochondrial events even in the setting of heightened Bcl 2 or Bcl xL expression . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 / E1B 19 kDa interacting protein 3 like protein ( Bnip3L ) interacts with bcl 2 / Bcl xL and induces apoptosis by altering mitochondrial membrane permeability . ^^^ Here we show that Bnip3L contains a motif similar to the BH 3 domain which is conserved in Bcl 2 family proteins as well as containing a membrane anchoring domain , and that Bnip3L interacts with Bcl 2 and Bcl xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
BAG 1 is an anti apoptotic protein that interacts with Bcl 2 , Bcl XL , Hsp70 / Hsc70 , Raf 1 and numerous hormone or growth factor receptors . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
For example , serine protein phosphorylation , which occurs during mitotic arrest or meiosis , explains paclitaxel induced hyperphosphorylation of Bcl 2 and Bcl xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Overexpression of the anti apoptotic proteins Bcl 2 or Bcl XL that blocked loss of the mitochondrial membrane potential and cytochrome c release from mitochondria conferred resistance to BetA at the level of mitochondrial dysfunction , protease activation and nuclear fragmentation . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
With the combination , the expression of Bax and Bcl xS , the apoptosis enhancing proteins , was more up regulated and that of Bcl 2 and Bcl xL , the apoptosis suppressing proteins , was more down regulated compared to the use of EPA or TNP 470 alone , suggesting that their synergistic effect was due to an acceleration of apoptosis . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In this study , we demonstrate that constitutive expression of bcl xl but not bcl 2 , bcl xs , bak , bad , or bax was associated with apoptosis resistance after IL 2 deprivation in CTLL 2 cells that expressed Tax . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Differential protective effects of Bcl xL and Bcl 2 on apoptotic liver injury in transgenic mice . ^^^ Although the broad antiapoptotic action of Bcl 2 and Bcl xL has been clearly established in various apoptotic pathways , their ability to inhibit the Fas / CD95 and TNF alpha mediated apoptotic signal has remained controversial . ^^^ Bcl xL and Bcl 2 were protective without any change in the level of endogenous Bcl xL or Bax and inhibited hepatic caspase 3 like activity . ^^^ Under these conditions , PK BCL XL mice were partially protected from liver injury and death but PK BCL 2 mice were not . ^^^ A similar differential protective effect of Bcl xL and Bcl 2 transgenes was observed when Fas / CD95 was activated and transcription blocked . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The antiapoptotic protein bcl 2 was apparently up regulated in A549 / UCN cells , however , bcl xL , another antiapoptotic protein , was down regulated , without changes in bak and bax . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Memory cells as opposed to effector cells show an inversion in the relative expression of Bcl 2 family members in favor of antiapoptotic molecules , and compared with naive cells they have an increased ratio of bcl xL to bcl 2 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The microtubule damaging antineoplastic drugs can kill tumor cells by inducing phosphorylation of antiapoptotic proteins such as Bcl 2 , Bcl xL or MCL 1 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The decision between survival or death in response to an apoptotic stimulus is determined and regulated in part by oncoproteins which include proteins of the Bcl 2 family ( bcl 2 , bax , bcl xL ) and bcr abl . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The expression of members of the Bcl 2 family of proteins , such as Bcl 2 , Bcl xL , Bax , and Bad , was unchanged by the overexpression of PHGPx in cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Prolonged incubation of HKC cells with HGF also dramatically induced expression of Bcl xL , an anti apoptotic member of the Bcl 2 family . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Abundant levels of Bcl 2 and Bcl XL , known to inhibit CD 95 signaling in some cells , were present suggesting a possible role for both molecules in the resistance to CD 95 mediated cell death . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Expression of Bcl 2 and its homologues , Bcl xL , Bcl xS , Bax , Bad , Bak and Bag 1 , was detected in all NHL cases , with wide variations between histological subtypes and within each subtype . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We have found that , in addition to Bcl 2 and Bax , the expression levels of apoptosis inducers ( Bad , Bak ) and inhibitors ( Bcl xL , Mcl 1 ) were highly variable in blasts from 78 children with newly diagnosed acute lymphoblastic leukemia ( ALL ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Consistent with the postulated role of CES 1 as an antiapoptotic transcription factor , SLUG was nearly as active as Bcl 2 or Bcl xL in promoting the survival of IL 3 dependent murine pro B cells deprived of the cytokine . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
This antioncogenic effect was specific to Bcl 2 and was not shared by other antiapoptotic genes such as bcl xL and a dominant negative form of p 53 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The bcl xL gene is a member of a family of apoptosis regulating genes and often displays the death inhibiting properties of the prototype of this family , bcl 2 . ^^^ It is of special interest to study bcl xL for possible brain protection , because , unlike bcl 2 , it is important for normal brain development . ^^^ CONCLUSIONS : Overexpression of bcl xL protects astrocytes from oxidative injury with the same spectrum of protection seen previously for bcl 2 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The expression of bcl 2 and bcl xL was higher and the expression of bax was lower in lower density cultures compared to higher density cultures at basal condition . ^^^ After incubation with stressors , bcl 2 and bcl xL expressions decreased and bax expression increased in both lower and higher density cultures . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Ginsenoside Rh 2 induces apoptosis independently of Bcl 2 , Bcl xL , or Bax in C6Bu 1 cells . ^^^ It was demonstrated that the expression of Bcl 2 , Bcl xL and Bax was not altered in ginsenoside Rh 2 treated C6Bu 1 cells . ^^^ These results suggest the existence of other apoptotic pathway that requires induction of apoptosis by ginsenoside Rh 2 rather than the pathway through Bcl 2 , Bcl xL or Bax in C6Bu 1 cells . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The ratio of the expression of Bcl 2 to Bax or Bcl xL to Bax , and XIAP expression in synovial cells may not be directly associated with the susceptibility of synovial cells to apoptosis by LLL CHO . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 , bax and bcl xL expression in human sensitive and resistant leukemia cell lines . ^^^ Furthermore , the role of bcl 2 and bcl xL apoptosis inhibitors as well as bax expression ( apoptosis inducer ) in human sensitive leukemic cell lines ( CCRF CEM and HL 60 ) as compared to their resistant variants such as CCRF CEM / ACT400 , CCRF CEM / VCR1000 , HL 60 / IDA40 , HL 60 / DNR250 was evaluated . ^^^ Bcl 2 and bax were analyzed by both flow cytometry and ECL Western blot , bcl xL by ECL Western blot alone . ^^^ Comparison of the two sensitive cell lines demonstrated different bcl 2 , bax and bcl xL patterns . ^^^ The common characteristic was the increased expression of one of the apoptosis inhibitor proteins , such as bcl 2 or bcl xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Immature hematopoietic progenitor cells ( CD34+ / 33 / 13 ) did not express Bcl 2 but Bcl XL , the majority of CD 34 cells expressed Bcl 2 , Bcl XL and BAD , and normal promyelocytes ( CD 34 / 33+ ) lacked expression of both Bcl 2 and Bcl XL , while leukemic CD34+progenitors and promyelocytes expressed these anti apoptotic proteins . ^^^ In AML , Bcl 2 expression was higher on CD34+ than on all AML cells , however , expression of Bcl 2 or Bcl XL did not predict achievement of complete remission . ^^^ Bcl 2 and Bcl XL were both expressed in minimal residual disease cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In the present study , we characterized the regulation of antiapoptotic ( Bcl 2 , Bcl xL ) and proapoptotic ( Bad , Bax ) Bcl 2 family proteins in the rat heart during development and in oxidative stress induced apoptosis . ^^^ Bcl 2 and Bcl xL were expressed at high levels in the neonate , and their expression was sustained during development . ^^^ In unstimulated neonatal cardiac myocytes , Bcl 2 and Bcl xL were associated with the mitochondria , but Bad and Bax were predominantly present in a crude cytosolic fraction . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Loss of the mitochondrial membrane potential ( MMP ) precedes the morphological changes in cell death , and overexpression of Bcl 2 or Bcl XL blocks apoptosis as well as hypoxia induced necrosis by maintaining MMP . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In the yeast two hybrid system , Mcl 1 binds to the hypophosphorylated mutant of BAD and interacts preferentially with different proapoptotic ( Bax , Bak , Bok , Bik , and BOD ) compared with antiapoptotic Bcl 2 family members ( Bcl 2 , Bcl xL , Bcl w , Bfl 1 , CED 9 , and BHRF 1 ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In asymptomatic transgenic mSOD 1 mice , expression of Bcl 2 , Bcl XL , Bad , and Bax does not differ from that in nontransgenic mice . ^^^ In contrast , in symptomatic mice , expression of Bcl 2 and Bcl XL , which inhibit apoptosis , is reduced , whereas expression of Bad and Bax , which stimulate apoptosis , is increased . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Expression of Bcl xL , Mcl 1 and Bcl 2 was found in most of the samples ; expression of Bcl xL and Mcl 1 seemed to be related on myeloma cells . ^^^ In a system of apoptosis by growth factor deprivation on myeloma cells , we showed that the effect of Bcl 2 seemed minimal whereas Mcl 1 and Bcl xL were tightly regulated by interleukin ( IL ) 6 . ^^^ These findings underline the important role of Mcl 1 and Bcl xL instead of Bcl 2 in IL 6 induced survival of myeloma cells . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The mechanism by which FDC spare malignant B cells from apoptosis did not involve alterations in levels of Bcl 2 , Bcl XL , or Bax . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In addition , ultraviolet B caused a decrease in BCL 2 and BCL xL expression in mock transfected keratinocytes , but not in nerve growth factor overexpressing cells . ^^^ These results are consistent with a model whereby the autocrine nerve growth factor protects human keratinocytes from ultraviolet B induced apoptosis by maintaining constant levels of BCL 2 and BCL xL , which in turn might block caspase activation . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Phosphorylation at either site results in loss of the ability of BAD to heterodimerize with the survival proteins BCL XL or BCL 2 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Induction of apoptosis in U 937 human leukemia cells by suberoylanilide hydroxamic acid ( SAHA ) proceeds through pathways that are regulated by Bcl 2 / Bcl XL , c Jun , and p21CIP1 , but independent of p 53 . ^^^ Enforced expression of Bcl 2 or Bcl XL inhibited SAHA induced apoptosis , but only modestly potentiated differentiation . ^^^ These findings indicate that SAHA potently induces apoptosis in human leukemia cells via a pathway that is p 53 independent but at least partially regulated by Bcl 2 / Bcl XL , p21CIP1 , and the c Jun / AP 1 signaling cascade . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
These pre apoptotic events were associated with the cleavage of the caspase 3 , while the expression of Bcl 2 , Bcl XL and Bax proteins was not affected by the presence of Tat . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
However , it is possible , at least in prostate cancer cell lines , that the ultimate decision for or against apoptosis may be modulated by a number of factors , including levels of Bcl family members , especially the antiapoptotic proteins bcl 2 and bcl xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The glutamate induced apoptosis appears to involve the modulation of Bcl 2 family gene products such as Bcl 2 , Bcl xL , and Bax alpha . ^^^ Both Bcl 2 and Bcl xL were down regulated by glutamate at 24 h and further at 48 h . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
B cell expression of Bcl xL was markedly increased by RA SCL in a contact dependent manner , whereas B cell expression of Bcl 2 was unaffected . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Overexpression of bcl 2 , bcl XL or hsp 70 in murine cortical astrocytes reduces injury of co cultured neurons . ^^^ We asked whether astrocytes overexpressing either the anti apoptotic genes bcl 2 , or bcl XL , or the inducible heat shock protein hsp 70 , could better protect neurons grown with them in co culture than normal astrocytes or astrocytes expressing beta galactosidase . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Immunohistochemistry and RT PCR showed that 71 % of the cell lines were Bcl 2 positive , 62 % were Bax positive , 38 % were Bcl XL positive and 62 % were Bcl XS positive . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In contrast , FcepsilonRI ligation enhances the expression of the antiapoptotic molecules Bcl 2 and Bcl xL , but not Mcl 1 , in monocytes . ^^^ These results indicate that FcepsilonRI mediates signals preventing monocyte apoptosis directly by increasing the levels of Bcl 2 and Bcl xL , and indirectly by means of TNF alpha in an autocrine and paracrine fashion . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Then we determined whether Bcl 2 , Bax , Bcl xL and Bcl xS , which regulate the release of cytochrome c from mitochondria , were altered in the ischemia tolerant CA 1 region . ^^^ Bcl 2 and Bax were up regulated in the ischemia tolerant group , but Bcl xL and Bcl xS showed no apparent difference in their expression . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
However , the basal levels of anti apoptotic proteins Bcl xL and Mcl 1 were 4 8 fold higher in A 2780 ( 100 ) than in A 2780 neither of which expressed Bcl 2 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Inhibition of endogenous p 53 activity did not affect the sensitivity of TAD 2 cells to iodide , and Western blot analysis demonstrated that p 53 , Bcl 2 , Bcl XL , and Bax protein expression did not change when cells were treated with iodide . ^^^ This type of apoptosis is p 53 independent , does not require protein synthesis , and is not induced by modulation of Bcl 2 , Bcl XL , or Bax protein expression . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Influence of age on hypoxia / reoxygenation induced DNA fragmentation and bcl 2 , bcl xl , bax and fas in the rat heart and brain . ^^^ The levels of the anti apoptotic proteins bcl 2 and bcl xL , were similar in young and old at baseline and tended to increase in both age groups after hypoxia / reoxygenation . ^^^ The ratios of bcl 2 / bax and of bcl xL / bax were higher in the old heart and brain compared to that in the young adult after hypoxia / reoxygenation . ^^^ Thus , compared to that of the young adult , the heart and brain of the old rat have lower thresholds and are more vulnerable to injury induced by hypoxia / reoxygenation , despite rapid and heightened expression of the anti apoptotic proteins bcl 2 and bcl xl . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The expression of Bcl 2 and Mcl 1 / EAT was up regulated 4 12 h after the treatment while Bcl XL was up regulated 2 3 days after the stimulation . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Furthermore , NGF transfected keratinocytes are protected from UV B induced keratinocyte apoptosis , by maintaining constant levels of Bcl 2 and Bcl xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In the multimodally treated esophageal cancer patients , strong expression of p21WAF1 and accumulation of p 53 were predictors of poor survival , whereas expression of Bcl 2 , Bax , and Bcl XL had no prognostic significance . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Surprisingly , antiapoptotic factors ( e . g . , bcl 2 and bcl xl ) were not overexpressed in poor prognostic tumors ( CCSK , RTK ) compared with those with good prognosis ( WT ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
To analyse the relative position of caspase 8 within the apoptotic cascade we studied caspase activation and apoptosis in Jurkat cells overexpressing Bcl 2 or Bcl xL . ^^^ In parallel , the breakdown of the mitochondrial transmembrane potential ( DeltaPsim ) in response to radiation was inhibited by overexpression of Bcl 2 / Bcl xL Jurkat cells genetically deficient for caspase 8 were found to be completely resistant towards CD 95 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Among multimodally treated esophageal cancer patients , again strong expression of p21WAF1 as well as accumulation of p 53 were predictors of poor survival , whereas expression of Bcl 2 , Bax and Bcl XL did not show any prognostic influence . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Apoptosis could be induced in cell lines that overexpressed Bcl 2 or Bcl XL when the cells were treated with anti Fas antibody , tumor necrosis factor alpha , staurosporine , or Bax , in addition to TC A . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
An immunohistochemical study showed that the lymphoma cells were positive for leukocyte common antigen , Epstein Barr virus , bax . and bcl XL , and negative for L 26 and bcl 2 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Molecular modeling showed that BFL 1 could have a similar core structure as BCL xL , consisting of seven alpha helices , although both proteins share only the conserved BCL 2 homology domains ( BH 1 and BH 2 domains ) , but otherwise have very limited sequence homology , particularly in the N terminal region . ^^^ We demonstrated in the yeast two hybrid system that BFL 1 interacts strongly with human BAX but is not able to form homodimers nor to interact with human BCL 2 or BCL xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In contrast to previous studies , we found no evidence of Bad binding to anti apoptotic Bcl 2 , Bcl XL or McI 1 , or of alterations in Bax heterodimers . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Several endogenous or viral inhibitors of apoptosis , including Bcl 2 , Bcl xL , FLIP , p 35 , and CrmA , have been shown to be cleaved by caspases during apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 and its relative , Bcl xL , inhibit apoptotic cell death primarily by controlling the activation of caspase proteases . ^^^ Previous reports have suggested at least two distinct mechanisms : Bcl 2 and Bcl xL may inhibit either the formation of the cytochrome c / Apaf 1 / caspase 9 apoptosome complex ( by preventing cytochrome c release from mitochondria ) or the function of this apoptosome ( through a direct interaction of Bcl 2 or Bcl xL with Apaf 1 ) . ^^^ These observations , together with previous results obtained with Bcl 2 , argue that Bcl xL and Bcl 2 can not block the apoptosome mediated activation of caspase 9 . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The cell death induced by overexpression of Bcl xS was inhibited by coexpression of Bcl xS with Bcl 2 or Bcl xL , or by treatment with the broad spectrum caspase inhibitor benzyloxycarbonyl Val Ala Asp fluoro methylketone ( Z VAD FMK ) or with NGF . ^^^ These results therefore suggest that the apoptotic pathway induced by overexpression of Bcl xS in PC 12 cells can be controlled by Bcl 2 and Bcl xL , is mediated by caspases , and can be inhibited by the NGF signaling pathway . ^^^ The Bax induced cell death was inhibited by co expression of Bax with Bcl 2 or Bcl xL , but was not inhibited by Z VAD FMK , NGF , or the Bcl 2 ml 3 or deltaC 22 mutants . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
This particular characteristic was not present in the B 95 8 strain or in the corresponding regions of homologues , Bcl 2 and Bcl XL , and was regarded as unique to Oriental EBV strains . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Ectopically expressed Bcl xL inhibited Ad Rbz Bcl 2 induced mitochondrial permeability transition and apoptosis in Ad Rbz Bcl 2 transduced cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We first analyzed mRNA expression of pro apoptotic Bak and Bax along with that of anti apoptotic Bcl 2 and Bcl xL , using breast cancer specimens of 27 patients . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In patients with CD , mucosal T cells showed strong evidence for IL 6 trans signaling , with activation of signal transducer and activator of transcription 3 , bcl 2 and bcl xl . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Using reverse transcriptase polymerase chain reaction , cloning , and sequencing techniques , we have found that HL 60 cells express bak , bik , bax , bad , bcl 2 , bcl xL , bcl w , bfl 1 , fas , and caspases 1 4 and 7 10 . ^^^ Peripheral blood neutrophils expressed bak , bad , bcl w , bfl 1 , fas , and caspases 1 , 3 , 4 , and 7 10 , but hardly expressed bcl 2 , bcl xL , bik , bax , and caspase 2 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The family can be divided into two classes : those such as Bcl 2 and Bcl xL that suppress cell death , and others , such as Bak and Bax , that appear to promote apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Overexpression of anti apoptotic Bcl 2 or Bcl xL abrogates stress signal mediated mitochondrial p 53 accumulation and apoptosis but not cell cycle arrest , suggesting a feedback signaling loop between p 53 and mitochondrial apoptotic regulators . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Calphostin C mediated apoptosis in glioma cells was reported previously to be associated with down regulation of Bcl 2 and Bcl xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Immunoblots showed no downregulation of Bcl 2 or Bcl xL and no upregulation of Bax , whereas decreased mitochondrial membrane potential was readily measurable 24 h after cytokine deprivation . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Susceptibility to drug induced apoptosis correlates with differential modulation of Bad , Bcl 2 and Bcl xL protein levels . ^^^ The earliest event induced by drug exposure was increase in Bad protein levels , followed by Bcl 2 down regulation , cytochrome c release , and Bcl xL and Bax up regulation . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Differential expression of antiapoptotic genes in human endometrial carcinoma : bcl XL succeeds bcl 2 function in neoplastic cells . ^^^ Transfection of bcl 2 and bcl XL into apoptosis sensitive cells was used to monitor the biological function of protective genes . ^^^ Resistant lines exhibited high amounts of Bcl XL and low amounts of Bcl 2 . ^^^ CONCLUSIONS : These data demonstrate , at the molecular level , that bcl XL is selected as an apoptosis protective gene in place of bcl 2 while bax retains its dominant proapototic role . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Neither Bcl XL nor Bcl 2 , which play important roles in antiapoptotic mechanisms in gliomas , protected glioma cells from apoptosis induced by overexpression of caspase 8 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
However , increases in the antiapoptotic proteins , Bcl 2 and Bcl xL , suggest a possible concomitant , compensatory antiapoptotic mechanism in patients with heart failure . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We have studied by immunocytochemistry , Western blotting and RT PCR the expression pattern of Bcl xL , Bcl 2 and BAX in the in vitro model of neuronal differentiation constituted by retinoic acid ( RA ) treated NTera 2 / D1 ( NT2 / D1 ) cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Inhibition of progression to androgen independence by combined adjuvant treatment with antisense BCL XL and antisense Bcl 2 oligonucleotides plus taxol after castration in the Shionogi tumor model . ^^^ Here , we characterize changes in bcl xL , another important anti apoptotic gene , and test the efficacy of adjuvant antisense Bcl xL ODN therapy either alone or in combination with antisense Bcl 2 ODN and chemotherapy after castration in the Shionogi tumor model . ^^^ We then examined whether combined adjuvant antisense Bcl xL and / or Bcl 2 ODNs plus taxol ( paclitaxel ) therapy further delays time to AI progression . ^^^ Combined treatment of Shionogi cells with antisense Bcl xL and Bcl 2 ODNs significantly enhanced taxol chemosensitivity compared with either agent alone , reducing the IC ( 50 ) of taxol by more than 1 log . ^^^ Apoptotic DNA laddering and cleavage of poly ( ADP ribose ) polymerase were more substantial after treatment with combined antisense Bcl 2 and Bcl xL ODNs plus taxol than that with either 2 agents . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Rac 2 ( / ) mast cells demonstrated a significant reduction in growth factor induced survival , which correlated with the lack of activation of Akt and significant changes in the expression of the Bcl 2 family members BAD and Bcl XL , in spite of a 3 fold induction of Rac 1 protein . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Tumor necrosis factor related apoptosis inducing ligand retains its apoptosis inducing capacity on Bcl 2 or Bcl xL overexpressing chemotherapy resistant tumor cells . ^^^ In contrast , various Bcl 2 or Bcl xL overexpressing tumor cell lines are sensitive to TRAIL induced apoptosis ; however , they show a delay in TRAIL induced mitochondrial permeability transition compared with control transfectants . ^^^ Tumor cells overexpressing Bcl 2 or Bcl xL become resistant to apoptosis induced by the chemotherapeutic drug etoposide . ^^^ Thus , TRAIL may still kill tumors that have acquired resistance to chemotherapeutic drugs by overexpression of Bcl 2 or Bcl xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Several studies demonstrate that the BCL 2 and BCL XL antiapoptotic genes are variably expressed in plasma cells of patients with multiple myeloma ( MM ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
A novel bispecific antisense oligonucleotide inhibiting both bcl 2 and bcl xL expression efficiently induces apoptosis in tumor cells . ^^^ Bcl 2 and Bcl xL are inhibitors of apoptosis frequently overexpressed in solid tumors . ^^^ The bcl 2 and bcl xL mRNAs share a region of homology comprising nucleotides 605 624 and 687 706 , respectively , which differs by only three nucleotides . ^^^ To test the possibility that oligonucleotides targeting this region have the potential to down regulate bcl 2 and bcl xL expression simultaneously , three 2 ' O methoxy ethoxy modified phosphorothioate oligonucleotides were designed . ^^^ These oligonucleotides differed in the number of mismatches to bcl 2 and bcl xL and in the number of nucleotides to which the modifications were made . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We have examined , in a rat glioma cell line A15A5 , the effect of the stable transfection of human bcl 2 , bax and bcl xl on MMPs expression . ^^^ In bcl 2 and bcl xl transfected cells , the transcription of MMP 9 was decreased compared to that of control or bax transfected cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Western blot analysis of Bcl 2 , Bcl xL and Bax expression and immunofluorescence analysis of promyelocytic leukemia ( PML ) protein indicated that apoptosis induced by spicamycin and KRN 5500 was associated with down regulation of Bcl 2 expression and modulation of PML protein . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Effects of Bcl 2 and Bcl XL protein levels on chemoresistance of hepatoblastoma HepG 2 cell line . ^^^ Sense bcl 2 , and anti sense bcl XL gene fragments were separately inserted into HepG 2 cells via stable transfection . ^^^ The chemosensitivity of HepG 2 cells to Taxol and Doxorubicin was not affected by Bcl 2 levels , while reduction of Bcl XL levels rendered the cells more sensitive to the drugs . ^^^ This suggests that the Bcl 2 protein alone could not protect HepG 2 cells from drug induced apoptosis , and that the Bcl XL protein may be a target for gene therapy in hepatoblastoma treatment . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Expression of CD 95 , Bax , Bcl xL , and Bcl 2 proteins was determined by western blotting . ^^^ RESULTS : Equal levels of expression of CD 95 , Bcl xL , and Bcl 2 proteins were noted in normal and UC colonic epithelia . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
METHODS : Using Western blotting and immunohistochemistry , the authors investigated the expression of bcl 2 , bcl xL , bax , caspase 1 , and caspase 3 in temporal cortex samples from patients who had undergone temporal lobectomy surgery for intractable epilepsy ( n = 19 ) . ^^^ RESULTS : Western blot analysis demonstrated significant increases in levels of bcl 2 and bcl xL protein in seizure brain compared to control . ^^^ Bcl 2 , bax , and caspase 3 immunoreactivity was increased predominantly in cells with the morphologic appearance of neurons , whereas bcl xL immunoreactivity was increased in cells with the appearance of glia . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
TrkA stimulation up regulates the expression of the anti apoptotic Bcl 2 family members , Bcl 2 , Bcl XL , and Bfl 1 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The anti apoptotic proteins like FLAME 1 , Bcl 2 and Bcl xL are believed to be such CHX sensitive inhibitors in various types of cancer cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
These results indicate that Bax promotes apoptosis regardless of ceramide formation and that Bcl 2 or Bcl xL prevents ceramide formation by repressing neutral sphingomyelinase as well as ceramide induced cytochrome c release . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The dependence on Bid , and thus on the mitochondrial cytochrome c release , of hepatocyte apoptosis induced by the death receptors also renders it sensitive to the inhibitory regulation by the anti apoptosis members of the Bcl 2 family proteins , such as Bcl 2 and Bcl xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
This suggests the possibility that the expression of genes such as bcl 2 or bcl xL is required to inhibit apoptosis induced by oncogene expression . ^^^ We hypothesized that inhibition of Bcl 2 / Bcl xL by the pro apoptotic Bcl xS protein , would result in selective induction of apoptosis in mammary carcinoma cells compared to their nontransformed counterparts . ^^^ These data are consistent with the hypothesis that inhibition of Bcl 2 / Bcl xL can result in selective killing of cancer cells compared to their nontransformed counterparts . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
To explore the potential involvement of Bcl 2 family members in this process , the expression and localization of some Bcl 2 family proteins ( Bcl 2 , Bcl xL , Bcl w , Bak , Bax , and Bad ) and p 53 were analyzed during testicular development in the rat by Western blotting and immunohistochemistry . ^^^ The dynamic changes in the expression profiles of Bcl 2 family proteins are consistent with a model in which germ cells are primed for apoptosis during the first cycle of spermatogenesis by de novo expression of the death effectors Bax and Bad in a p 53 dependent manner and these proteins are prevented from triggering further apoptosis after the first spermatogenic cycle has been set up by anti apoptotic Bcl 2 family proteins Bcl xL and Bcl w . ^^^ The data suggest that SCF supports germ cell survival during spermatogenesis by up regulating pro survival Bcl 2 family proteins , Bcl w and Bcl xL , and down regulating pro apoptosis Bcl 2 family proteins , e . g . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Evaluation of antiapoptotic gene transcripts shows an upregulation in the expression of cFLIP , Bcl 2 , Bcl xL , DAD 1 and survivin . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Caspase 9 is autoprocessed by the Apaf 1 / cytochrome c pathway and acts at an early point in this cascade , whereas Bcl xL , an antiapoptotic member of the Bcl 2 family , prevents activation of caspases in vitro . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
An increase in the antiapoptotic Bcl 2 and Bcl xL protein levels and a decrease in the proapoptotic Bax and Bcl xS protein levels were also detected by Western blot analysis after SNAP treatment . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Moreover , the caspase inhibitor zVAD fluoromethylketone as well as expression of bcl 2 or bcl xL inhibited cortical neuron apoptosis induced by arsenite or by constitutive activation of JNK or p 38 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Importantly , the early release of cytochrome c from mitochondria closely correlates with the degradation of Bcl 2 and Bcl xL and a decrease in the ratios of Bcl 2 and Bcl xL to Bax during STA . ^^^ These findings suggest that the degradation of Bcl 2 and Bcl xL may favor Bax to induce cytochrome c release from mitochondria , which subsequently activates downstream caspases in STA . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
As targets for participation in apoptosis , Bcl 2 and Bcl xl were phosphorylated in response to JNK activation by taxol or UV ; this was prevented by E 2 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The data also indicate that Bcl xL and Bax possess an ability to regulate mitochondrial membrane permeability independently of other Bcl 2 family members . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The mitochondrial permeability transition ( PT ) pore , also called the mitochondrial megachannel , is a multiprotein complex formed at the contact site between the mitochondrial inner and outer membranes , exactly the same location at which Bax , Bcl 2 and Bcl XL are particularly abundant . ^^^ Thirdly , opening of the purified PT pore complex reconstituted into liposomes is inhibited by recombinant Bcl 2 or Bcl XL , two apoptosis inhibitory proteins that also prevent PT pore opening in cells and isolated mitochondria . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
High cyclin dependent kinase inhibitors in Bcl 2 and Bcl xL expressing CD34+ proliferating haematopoietic progenitors . ^^^ C myc and p 53 levels were higher in bright cells than in d 0 CD34+ and dim cells , and so was Bcl xL , which followed the trend we have previously described for Bcl 2 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
METHODS AND RESULTS : By counting apoptotic biliary cells and by immunostaining apoptosis related proteins in normal liver , fatty liver , and those with acute viral hepatitis , chronic viral hepatitis , and hepatitis virus related cirrhosis , it was found that the larger the intrahepatic bile ducts became , the more biliary epithelial cells underwent apoptosis . bcl 2 , an inhibitor of apoptosis , was diffusely expressed in the interlobular bile ducts , but rarely detectable in the large and septal bile ducts . bcl XL and mcl 1 , inhibitors of apoptosis , and bax , a promoter of apoptosis , were diffusely expressed along the intrahepatic biliary tree . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Attenuation of apoptosis by BLyS correlates with changes in the ratios between Bcl 2 family proteins in favor of cell survival , predominantly by reducing the proapoptotic Bak and increasing its prosurvival partners , Bcl 2 and Bcl xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The anti apoptotic members of the family , such as Bcl 2 and Bcl XL , protect the integrity of the mitochondrion and prevent the release of death inducing factors . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Like other antimicrotubule agents , the sulfamoylated estrone derivatives induced BCL 2 and BCL XL phosphorylation and increased p 53 expression . 2 MeOEMATE and 2 EtEMATE are novel antimicrotubule agents that have potent anticancer activity in breast cancer cells in vitro and may be beneficial as anticancer agents in vivo . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
CD 40 ligand , Bcl 2 , and Bcl xL spare group 1 Burkitt lymphoma cells from CD 77 directed killing via Verotoxin 1 B chain but fail to protect against the holotoxin . ^^^ Ectopic expression of either bcl 2 or bcl xL also afforded resistance to the actions of the B chain . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
However , anti apoptotic factors including Bcl 2 , Bcl xL , and Mcl 1 were significantly induced in the adherent population whereas no induction was detectable in the suspension cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
There was no correlation between expression of members of the Bcl 2 family ( Bcl 2 , Bcl xL , Bax , and Bak ) and TRAIL sensitivity . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
This is accompanied by progestin up regulation of the antiapoptotic protein bcl xL , no effect on the proapoptotic protein bax , and , surprisingly , diminution of the antiapoptotic protein bcl 2 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The effect of TBI on regional cellular patterns of expression of survival promoting proteins such as Bcl 2 , Bcl xL , and extracellular signal regulated kinases , and death inducing proteins such as Bax , c Jun N terminal kinase , tumor suppressor gene , p 53 , and the caspase family of proteases are reviewed . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The Bcl 2 family members Bcl xL , and the adenovirus protein E1B 19K , inhibited Cdc 42 mediated apoptosis , whereas Bcl 2 did not . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl xL , is an anti apoptotic protein with a high degree of homology to Bcl 2 ; however , the signals that regulate Bcl xL and Bcl 2 appear to be different . ^^^ Levels of Bcl xL , but not Bcl 2 , are increased in response to various survival signals . ^^^ Furthermore , an inverse correlation between the levels of Bcl 2 and Bcl xL has been reported for a number of cancers . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Both Bcl xL and Bcl 2 , antiapoptotic members of the Bcl family , are found in prostate cancer cell lines . ^^^ The first strategy used CS propynylated phosphorothioate phosphodiester oligonucleotides and co down regulated both Bcl xL and Bcl 2 ; the second strategy used isosequential `` gap mer ' ' phosphorothioate oligonucleotides containing 2 ' O methyl oligoribonucleotides at the 3 ' and 5 ' termini . ^^^ However , the increase in chemosensitivity in PC 3 cells was statistically identical ( except mitoxantrone ) for both `` antisense ' ' strategies , indicating that basal expression of Bcl 2 , in contrast to that of Bcl xL , may play little cytoprotective role in these cells . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Western blot analysis did not display variations in the expression of p 53 , Bcl 2 , Bcl XL , and Bax proteins during the treatment with AMD and DEA . ^^^ These data indicate that AMD induces cytochrome c release from mitochondria , triggering apoptosis through an iodine independent mechanism , and that this process is not mediated by modulation of p 53 , Bcl 2 , Bcl XL , or Bax protein expression and does not involve the generation of free radicals . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Neither the putative BH 3 domain nor conserved domain is necessary for killing . ceBNIP 3 protein interacts with CED 9 and BCL XL , but unlike other pro apoptotic BCL 2 family members , the BH 3 like domain does not participate in dimerization . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We focused on the role of the Bcl 2 family member Bcl XL , using three pancreatic carcinoma cell lines as a model system , two of which have high ( Panc 1 , PancTuI ) and one has low ( Colo 357 ) Bcl XL expression . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
BCL XL is a key anti apoptotic BCL 2 family protein that is widely expressed in human cancer cells and is induced in response to diverse survival signals . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
A novel protein , RTN XS , interacts with both Bcl XL and Bcl 2 on endoplasmic reticulum and reduces their anti apoptotic activity . ^^^ Bcl 2 and Bcl XL serve as critical inhibitors of apoptosis triggered by a broad range of stimuli , mainly acting on the mitochondria . ^^^ We identified two members of the reticulon ( RTN ) family as Bcl XL binding proteins , i . e . , NSP C ( RTN 1 C ) and a new family member , RTN XS , both of which did not belong to the Bcl 2 family and were predominantly localized on the endoplasmic reticulum ( ER ) . ^^^ RTN XS interacted with both Bcl XL and Bcl 2 , increased the localization of Bcl XL and Bcl 2 on the ER , and reduced the anti apoptotic activity of Bcl XL and Bcl 2 . ^^^ On the other hand , NSP C interacted only with Bcl XL , affected the localization of Bcl XL , and reduced Bcl XL activity , but had no effect on Bcl 2 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Also , levels of the anti apoptotic proteins , Bcl 2 and Bcl xL were elevated in VHL positive cells , consistent with the protection from apoptotic stimuli . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Expression of other apoptosis related genes ( bcl 2 , bcl XL , bax , bad , caspase 3 ) was not affected by light exposure or the lack of c Fos in knockout mice . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 and Bcl xL are apoptosis suppressing oncogenes . ^^^ To investigate the possible prevention of salivary glandular destruction in SS by Bcl 2 and Bcl xL , stable transfectants expressing these molecules were made from HSY cells , a human salivary epithelial cell line . ^^^ HSY cells were transfected with an expression vector for human Bcl 2 or Bcl xL . ^^^ Fas mediated apoptosis was significantly inhibited in Bcl 2 and Bcl xL transfectants compared to wild type and control transfectants ( empty vector ) . ^^^ Surprisingly , caspase activity was not inhibited in Bcl 2 and Bcl xL transfectants . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In separate experiments , brains of sham operated control and HI only animals and animals subjected to HI plus C 2 ceramide or DMSO infusion were sampled 6 hours , 24 hours , and 5 days after treatments and analyzed for Bcl 2 , Bcl xl , and Bax expression ( Western blotting ) , and apoptosis ( TUNEL assay ) . ^^^ Augmented Bcl 2 and Bcl xl levels in the C 2 ceramide treated group were associated with a significant decrease in TUNEL positive cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
However , stable expression of Bcl 2 and Bcl xL did suppress these apoptotic events , including the release of cytochrome c from mitochondria , which was observed in drug treated H 460 cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Anti apoptotic proteins Bcl 2 , Bcl XL and CrmA as well as peptide inhibitors of caspases , DEVD CHO and zVAD FMK , failed to rescue tumor cells from Ad . asHsp70 induced cell death . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We assessed the protein expression levels of bcl 2 , bax , bcl xL , and bcl xS in a group of 51 endometrial cancers and 8 normal samples as well as in 59 cervical neoplasms and in 15 normal cervical tissues . ^^^ In endometrial carcinoma , bcl 2 and bcl xL levels were correlated inversely ( r = 0 . 27 ; P < . 054 ) , whereas in cervical cancer , they were correlated directly ( r = +0 . 40 ; P < . 002 ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The present study examines the contributions of apoptosis related proteins ( Bcl 2 , Bcl XL , Bax , and p21WAF1 / CIP1 ) in the regulation of T cell death induced by butyric acid , using p 53 knock out ( p 53 / ) and wild type ( p53+ / + ) mice . ^^^ Western blotting analysis of splenic T cells showed that butyric acid treatment decreased Bcl 2 and Bcl XL expressions in p53+ / + and p 53 / cells . ^^^ These results suggest that butyric acid mediated apoptosis of murine T cells takes place via a pathway that is independent of p 53 , and is followed by the p 53 regulated proteins Bax and p21WAF1 / CIP1 , which lower the levels of the apoptosis antagonists Bcl 2 and Bcl XL in cells . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
RESULTS : The techniques used herein determined accumulation of paclitaxel / PSC 833 induced apoptotic cells with sub G 0 ( hypodiploid ) DNA content and blocked in the G2 / M phase of the cell cycle , internucleosomal DNA fragmentation , poly ( ADP ribose ) polymerase cleavage , Bcl 2 modulation and Bax up regulation , without any significant alterations in the levels of Bcl xL , CD95 / Fas or Fas L proteins . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
A number of signal transducers and transcription factors have been associated with the antiapoptotic phenotype of CML cells , some of which lead to the expression and / or activation of members of the Bcl 2 family of apoptosis modulators , such as Bcl xL and Bad . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The expression of proapoptotic ( Bad , Bak , Bax ) and antiapoptotic ( Bcl 2 , Bcl XL ) genes was analyzed by quantitative RT PCR . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 gene and its family genes Bax , Bcl Xl as well as Fas / Apo 1 and their clinical significance in acute leukemia . ^^^ OBJECTIVE : To study the suppressing genes of apoptosis , namely Bcl 2 , its family genes Bax , Bcl Xl , and the inducing gene of apoptosis Fas / Apo 1 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In mammals , the CED 9 homologs Bcl 2 and Bcl xL also block apoptosis by interfering with the activation of CED 3 like caspases . ^^^ Whilst two groups previously detected an interaction between Bcl xL and Apaf 1 in immunoprecipitates , 1 , 2 another group found no interaction between Apaf 1 and any of ten individual members of the Bcl 2 family using the same experimental approach . 3 In this study , we aimed to resolve this discrepancy by monitoring the binding of Apaf 1 to three Bcl 2 family members within cells . ^^^ Using immunofluorescence and Western blot analysis , we show that whilst Apaf 1 is a predominantly cytoplasmic protein , Bcl 2 , Bcl xL and Bax mostly reside on nuclear / ER and mitochondrial membranes . ^^^ This pattern of localization is maintained when the proteins are co expressed in both normal and apoptotic cells , suggesting that Bcl 2 , Bcl xL or Bax do not significantly sequester cytoplasmic Apaf 1 to intracellular membranes . ^^^ In addition , we confirm that Apaf 1 does not interact with Bcl 2 and Bcl xL in immunoprecipitates . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Anti apoptotic genes bcl w , bcl 2 and bcl xL were all expressed in spermatogonia during juvenile spermatogenesis , but only bcl w was detected in spermatogonia of adult mice . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
High expression of anti apoptotic members such as Bcl 2 and Bcl XL commonly found in human cancers contributes to neoplastic cell expansion and interferes with the therapeutic action of many chemotherapeutic drugs . ^^^ The functional blockade of Bcl 2 or Bcl XL could either restore the apoptotic process in tumor cells or sensitize these tumors for chemo and radiotherapies . ^^^ This article reviews the recent progress in the design and discovery of small molecules that block the anti apoptotic function of Bcl 2 or Bcl XL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Expression of Tax in a human T cell line , Jurkat , induced the expression of the Bcl xL gene , but did not significantly affect the expression of the other apoptosis related genes , Bcl 2 and Bax . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
METHODS : Five pancreatic cell lines were investigated for the expression of FasL / Fas , DcR 3 , DR 4 , DR5 / TRAIL , DcR 1 , DcR 2 , and other death pathways related molecules such as Bax , bcl xL , bcl 2 , FADD , and caspase 3 by flow cytometry , immunoblotting , and RT / PCR , both semiquantitative and real time ( TaqMan ) . ^^^ One is the expression of nonfunctional receptors , decoy receptors , and molecules that block cell death , such as bcl 2 and bcl xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The deficiency of PAI 1 in the medium caused a significant reduction in Bcl 2 and Bcl XL mRNAs and an increase in Bcl XS and Bax mRNAs in PC 12 neurons at 3 h . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
PURPOSE : We investigated antisense inhibition of anti apoptotic bcl xL and bcl 2 proteins to increase chemosensitization in the T 24 and 5637 bladder carcinoma cell lines . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We also investigated intracellular levels of Bcl 2 , bcl xl and bax in CD 4 ( + ) and CD 8 ( + ) CVI T cells , as well as the bax / Bcl 2 ratio , using flow cytometry techniques but could not detect any differences between CVI and normal subjects . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Expression of the antiapoptotic genes bcl 2 and bcl xL was higher in the stromal cell dependent cell line than in the cytokine dependent cell lines . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Survival factors activate kinases which , in turn , phosphorylate the proapoptotic Bcl xl / Bcl 2 associated death promoter homolog ( BAD ) protein at key serine residues . ^^^ Although BAD is known to interact with Bcl 2 , Bcl w , and Bcl xL , the exact relationship between BAD and anti or proapoptotic Bcl 2 proteins has not been analyzed systematically . ^^^ Even though wild type BAD only interacted with selected numbers of antiapoptotic proteins , underphosphorylated mutant BAD interacted with all antiapoptotic Bcl 2 proteins tested ( Bcl 2 , Bcl w , Bcl xL , Bfl 1 / A1 , Mcl 1 , Ced 9 , and BHRF 1 ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Therefore , we studied the cell cycle proteins , Rb , E2F2 , Ki 67 , p 21 and p 53 and the apoptotic proteins , mcl 1 , hax , bcl xl , bcl 2 , Fas receptor , Fas ligand , caspase 3 , M 30 and PARP as potential predictive factors . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We therefore assessed expression levels of the anti apoptotic proteins BCL 2 and BCL XL and the pro apoptotic proteins BAX and BCL XS in T / null cell ALCL using immunohistochemical methods and correlated the findings with ALK expression and apoptotic rate ( AR ) , the latter assessed by a modified Tdt mediated dUTP nick end labeling assay . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Expression of bcl 2 , bax and bcl xl in human gliomas : a re appraisal . ^^^ We have analyzed the expression of the anti apoptotic proteins bcl 2 , bcl xl and that of bax , a pro apoptotic protein , in human WHO grade 2 astrocytomas ( LGA ) and WHO grade 4 glioblastoma multiforme ( GBM ) . ^^^ Confocal analyses provide us with another possible level of complexicity in the regulation of apoptosis in these tumors , as these markers exhibited different subcellular localizations : bcl 2 was strictly associated with mitochondria and bcl xl was present in both cytosolic and mitochondrial compartments while bax was found essentially in the cytosol of the tumoral cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Recently developed antisense oligonucleotides with the ability to inhibit the expression of anti apoptotic proteins , including Bcl 2 , Bcl xL , FLIP and surviving , have been shown to facilitate tumor cell apoptosis and sensitize tumor cells to cytotoxic treatments . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
During the induction of chemoresistance , the appearance of a functional P glycoprotein ( P gp ) , in addition to the expression of anti apoptotic Bcl 2 , Bcl XL and pro apoptotic Bax proteins was assessed . ^^^ In addition , the synthesis of Bcl 2 appeared to be replaced by Bcl XL while that of Bax remained unchanged . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The fibronectin mediated antiapoptotic mechanism in Bcr Abl active cells was not mediated by overexpression of Bcl XL or Bcl 2 but required an active phosphatidylinositol 3 kinase ( PI 3K ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The neurons died by a caspase dependent mechanism after inhibition of PI 3 kinase , and were also killed by antisense Bcl xL and antisense Bcl 2 or by overexpression of Bcl xS , Bad , and Bax . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The combination of Raf and either PI3K or Akt expression relieved cytokine dependence of some FL5 . 12 cells , and the efficiency of transformation could be enhanced further by Bcl 2 or Bcl XL overexpression . ^^^ Thus , the antiapoptotic PI3K / Akt and Bcl 2 / Bcl XL proteins can interact with the growth promoting Raf / MEK / ERK pathway and annul the cytokine dependence of certain hematopoietic cells . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The expression of regulating molecules was analyzed by using western blotting for p 53 , Bcl 2 , Bax , Bcl XL , Bcl XS , and p 21 ( WAF1 / CIP1 ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
While bcl 2 , bax , NFkappaB and p 53 gene expression were spontaneously upregulated , bcl xL and p21WAF1 gene expression decreased and IkappaB remained unchanged during the activation process in vitro . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
OX 40 promotes Bcl xL and Bcl 2 expression and is essential for long term survival of CD 4 T cells . ^^^ However , OX 40 / T cells fail to maintain high levels of Bcl xL and Bcl 2 4 8 days after activation , and undergo apoptosis . ^^^ Conversely , OX 40 stimulation promotes Bcl xL and Bcl 2 and suppresses apoptosis . ^^^ Moreover , retroviral transduction of OX 40 / T cells with Bcl xL or Bcl 2 reverses their survival defect . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
HuH 7 cells do not express Bcl 2 ; however , down regulation of Bcl xL expression preceded activation of the caspase cascade in GGOH treated HuH 7 cells , while Bax expression was not changed by GGOH treatment . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
GDNF protects against aluminum induced apoptosis in rabbits by upregulating Bcl 2 and Bcl XL and inhibiting mitochondrial Bax translocation . ^^^ Coadministration of glial cell neuronal derived factor ( GDNF ) inhibits these Bcl 2 and Bax changes , upregulates Bcl XL , and abolishes the caspase 3 activity . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
GM CSF withdrawal induced cell cycle arrest and apoptosis accompanied by increased caspase 3 activity , DNA degradation and reduced expression of the antiapoptotic Bcl 2 and Bcl xl proteins . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
After neutrophils were incubated with HPWE , expression of Bcl 2 family [ antiapoptotic ( Bcl 2 , Bcl XL and Mcl 1 ) and proapoptotic ( Bax , Bak and Bcl XS ) ] was determined by RT PCR and Western blotting , respectively . ^^^ The expression of Bax and Bak was upregulated and Bcl 2 , Bcl XL and Mcl 1 downregulated in HL 60 cells during neutrophilic differentiation . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Docetaxel is believed to have a twofold mechanism of antineoplastic activity : ( 1 ) inhibition of microtubular depolymerization , and ( 2 ) attenuation of the effects of bcl 2 and bcl xL gene expression . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
This also resulted in a dose dependent decrease in Bcl 2 and Bcl xL protein expressions . ^^^ This is closely associated with [ 1 ] the down regulation of Bcl 2 and Bcl xL proteins and [ 2 ] upregulation of Bax and Bad , whose gene products are known to be involved the regulation of apoptosis in mammalian cells . ^^^ These findings suggest that modulation of Bax , Bcl xL , Bcl 2 and Bad proteins by ICI may be , in part , responsible for the anti proliferative and apoptotic effect of ICI seen clinically and in animal models . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
BAD induces apoptosis in cells over expressing Bcl 2 or Bcl xL without loss of mitochondrial membrane potential . ^^^ A potential prototype of such a compound is the endogenous Bcl 2 and Bcl xL binding protein BAD . ^^^ Previous reports indicate that BAD can overcome the anti apoptotic effect of Bcl xL but not Bcl 2 . ^^^ We report that transient transfection of BAD induced cell death in cells with and without over expression of Bcl 2 or Bcl xL . ^^^ Forty eight hours after transfection , BAD increased cell death in COS , COS Bcl 2 , and COS Bcl xL cells as demonstrated by decreased GFP expression , and an increase in the number of number of floating cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
At that time , the whole kidney mRNA expression of the apoptosis inhibitory genes bcl xL and bcl 2 , as well as that of the apoptosis promotor bax , was significantly reduced . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
It has been shown that mesothelioma expresses the antiapoptotic protein BCL XL , but not BCL 2 , rendering bcl xl gene expression a potential therapeutic target . ^^^ A significant decrease in BCL XL protein expression was noted with BAK , BAX , and BCL 2 unchanged , and this was corroborated at the transcriptional level with selectively decreased bcl xl mRNA production after sodium butyrate exposure . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Finally , the apoptotic regulatory molecules Bcl 2 , Bcl xL , and Bax , do not appear to play a significant role in the regulation of eosinophil apoptosis in the schistosome granuloma . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
RT PCR and Western blot demonstrated that mRNA and protein expression for Bcl 2 and Bcl XL was substantially increased by the IL 6 treatment in CEPAC 1 cells , but not in AsPC 1 cells . ^^^ In 6 inhibits radiation induced apoptosis and enhances the survival of the cells through a functional receptor system , which is associated with the up regulation of anti apoptotic Bcl 2 family proteins , especially Bcl XL . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
High expression of endogenous bcl 2 and bcl xL in thymic lymphomas do not diminish their sensitivity to etoposide induced apoptosis . ^^^ We selected lymphoma clones with strong expression of anti apoptotic proteins Bcl 2 or Bcl xL and found that in contrast to proteins encoded by exogenous genes in other model systems , over expression of endogenous Bcl 2 and Bcl xL proteins failed to protect against etoposide induced apoptosis . ^^^ Treatment with etoposide did not decrease the ratio of anti apoptotic Bcl 2 and Bcl xL proteins to pro apoptotic Bax protein . ^^^ Results presented here suggest that high expression of Bcl 2 and Bcl xL may not diminish susceptibility of T cell lymphomas to chemotherapy with etoposide . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Finally , examination of other factors , such as bcl 2 , bcl xl , caspase 3 , and caspase 9 , demonstrated significant changes that were correlated with oxLDL treatment and ILK overexpression . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
To maintain ATP / ADP exchange , JY cells were transfected with bcl 2 and bcl xL and incubated with Ltx . ^^^ ATP levels of the transfected cells decreased to 67 % ( JY / bcl 2 ) and 73 % ( JY / bcl xL ) after the experiment . ^^^ Furthermore , cytochrome c remained localized to the mitochondrial fraction of Ltx treated JY / bcl 2 and JY / bcl xL cells , whereas its presence in the cytoplasmic fraction of JY / gen cells suggests an uncoupling of electron transport . ^^^ Expression of bcl 2 and bcl xL in cells inhibited downstream apoptotic events such as cleavage of poly ( ADP ribose ) polymerase , DNA fragmentation and activation of a family of caspases . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
To gain insight into the function of alpha synuclein , the present study examined the association between alpha synuclein and the following Bcl 2 family proteins : Bcl 2 ; Bcl XL ; Bcl associated death promoter ( BAD ) ; and Bcl 2 associated 10 protein . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The search for the corresponding effector genes revealed that the expression of FKBP 25 , FKBP 38 and FKBP 52 ( analysis by reverse transcription polymerase chain reaction ( RT PCR ) did not change following H ( 2 ) O ( 2 ) or FK 506 , and this was also true for the expression of apoptosis related genes caspase 3 , bax , bcl 2 and bcl xL ( analysis by Multiplex PCR ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Moreover , virus specific anergic CD 8 ( + ) T cells in persistently infected C57BL / 6 mice contain higher levels of Bcl 2 and Bcl XL than functionally intact T cells generated during acute LCMV infection . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Curcumin alone induced apoptosis in both cell types , which correlated with the downregulation of the expression of Bcl 2 and Bcl xL and the activation of procaspase 3 and procaspase 8 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Curcumin ( diferuloylmethane ) induces apoptosis through activation of caspase 8 , BID cleavage and cytochrome c release : its suppression by ectopic expression of Bcl 2 and Bcl xl . ^^^ The apoptotic intermediates through which curcumin exhibits its cytotoxic effects against tumor cells are not known , and the participation of antiapoptotic proteins Bcl 2 or Bcl xl in the curcumin induced apoptosis pathway is not established . ^^^ In the present report we investigated the effect of curcumin on the activation of the apoptotic pathway in human acute myelogenous leukemia HL 60 cells and in established stable cell lines expressing Bcl 2 and Bcl xl . ^^^ Curcumin inhibited the growth of HL 60 cells ( neo ) in a dose and time dependent manner , whereas Bcl 2 and Bcl xl transfected cells were relatively resistant . ^^^ Curcumin activated caspase 8 and caspase 3 in HL 60 neo cells but not in Bcl 2 and Bcl xl transfected cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We show here that TPO supports the survival of TPO dependent leukemia cell line UT 7 / TPO and normal megakaryocytic progenitors via the induction of Bcl xL , an anti apoptotic member of the Bcl 2 family . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Protein expression levels of p 53 , bcl 2 and bcl xl were examined by Western blotting . ^^^ An inhibitor of caspase , zVAD . fmk , blocked the apoptotic morphologic changes and DNA fragmentation but did not change the rate of cell death or the protein levels of p 53 , bcl 2 and bcl xl . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Moreover , while expression levels of apoptosis inhibitors , Bcl 2 and Bcl XL were increased following UC treatment , that of an apoptosis promoter , Bax , was decreased . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
PURPOSE : To detect cell specific apoptosis factors , Fas and Fas ligand , and the common intracellular apoptosis modulators , interleukin 1 beta converting enzyme ( ICE ) like protease ( caspase 1 ) , Bcl 2 , Bcl xL and Bax in lens epithelial cells ( LEC ) of human cataracts . ^^^ METHODS : Reverse transcriptase polymerase chain reaction ( RT PCR ) was used to detect Fas , Fas ligand , caspase 1 , Bcl 2 , Bcl xL and Bax , after cDNA was synthesized from the total RNA isolated from human cataractous LEC obtained by capsulotomy during cataract surgery . ^^^ RESULTS : Fas , caspase 1 , Bcl 2 , Bcl xL and Bax mRNA were detected by RT PCR . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Induction of apoptosis was associated with increased expression of CD95L ; activation of caspase 3 , however , did not affect the expression of Bcl 2 and Bcl xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Western blotting analysis demonstrated that hypoxia increased expression of antiapoptotic proteins such as Bcl 2 , Bcl XL , and IAP family members . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In support of these observations we found that Bcl 2 and Bcl xL can block caspase 2 and CRADD ( caspase and RIP adaptor with death domain ) induced cell death . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
IFN gamma or TRAIL treatment alone did not change expression of other pro or antiapoptotic proteins such as DR 4 , DR 5 , FADD , Bax , IAP 1 , XIAP , Bcl 2 , and Bcl XL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 and bcl xL antisense oligonucleotides induce apoptosis in melanoma cells of different clinical stages . ^^^ To further demonstrate the importance of bcl 2 and validate the related antiapoptotic protein bcl xL as targets for antisense therapy in melanoma , their implication as survival factors in melanoma cells of different clinical stages as well as in normal melanocytes was investigated . ^^^ Primary cell cultures derived from 17 melanomas , the cell line A 375 , and normal melanocytes from healthy donors were treated with antisense oligonucleotides targeting either the bcl xL mRNA or the bcl 2 and the bcl xL mRNAs simultaneously . ^^^ Bcl 2 and bcl xL expression in cells was analyzed by real time polymerase chain reaction and Western blotting . ^^^ As shown in A 375 cells and the stage 3 melanoma cells 0513 , both the bcl xL monospecific oligonucleotide 4259 and the bcl 2 / bcl xL bispecific oligonucleotide 4625 effectively reduced tumor cell viability by induction of apoptosis with IC 50 values ranging from 200 to 350 nM . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
It is known that infection with Sindbis virus ( SNV ) induces apoptosis , which is inhibited by two pro survival members of the Bcl 2 family , Bcl 2 and Bcl xL . ^^^ On the other hand , the structurally most similar pro survival members , Bcl 2 , Bcl xL , and Bcl w , suppressed SNV induced apoptosis in the absence of Bad , whereas Mcl 1 and A 1 did not . ^^^ Bad could be coimmunoprecipitated with Bcl xL or Bcl 2 , but not with Bcl w . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The predictive value of bcl 2 , bax , bcl xL , bag 1 , fas , and fasL for chemotherapy response in advanced breast cancer . ^^^ In 126 patients , histological blocks of primary tumors were available for immunohistochemical analysis of bax , bcl 2 , bcl xL , bag 1 , fas and fasL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Ribonuclease protection assays compared the effects of acetaminophen and E 2 on expression of selected genes ( c myc , c fos , cyclin D 1 , bcl 2 , bax , gadd 45 , mcl 1 , p 53 , p 21 ( CIP1 / WAF1 ) , and bcl xL ) in E 2 responsive breast cancer ( MCF 7 ) and endometrial adenocarcinoma ( Ishikawa ) cells as well as in E 2 nonresponsive ( MDA MB 231 ) breast cancer cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The delivery of transgenes capable of interfering with antigenic recognition and / or cell death [ e . g . , Fas ligand ( FasL ) , Bcl 2 , Bcl XL ] as well as imparting tolerance / immunoregulation [ e . g . , interleukin ( IL ) 4 , IL 10 , transforming growth factor ( TGF ) beta ] , or cytoprotection [ e . g . , heme oxygenase 1 ( HO 1 ) , catalase , manganese superoxide dismutase ( MnSOD ) ] may prevent recurrent type 1 diabetes in islet transplantation and offer a promising form of immunotherapy . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Interestingly , following cisplatin treatment , the same extent of increase in cytoplasmic Cyt c was evident and the expression of Bcl 2 family proteins ( Bcl 2 and Bcl XL ) remained unchanged in both CRHNSCCs and CSHNSCCs . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Ectopic expression of Bcl 2 and Bcl xL inhibits apoptosis induced by TNF related apoptosis inducing ligand ( TRAIL ) through suppression of caspases 8 , 7 , and 3 and BID cleavage in human acute myelogenous leukemia cell line HL 60 . ^^^ We investigated the effect of ectopic expression of Bcl 2 and Bcl xL on TRAIL induced apoptosis in human acute myelogenous leukemia HL 60 cells . ^^^ The expression of Bcl 2 and Bcl xL , however , completely abolished the TRAIL induced cytotoxic effects . ^^^ Treatment of HL 60 cells with TRAIL induced caspase 8 activation within 2 4 h , but no activation could be seen in Bcl 2 expressing or Bcl xL expressing cells . ^^^ TRAIL also induced cleavage of BID , which was also abolished by Bcl 2 and Bcl xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In Cy / + rat kidneys , decreased expression of anti apoptotic Bcl XL coincided with increased caspase 3 activity at 2 weeks of age while expression of Bcl 2 , another anti apoptotic protein , increased at 6 weeks of age . ^^^ In Cy / Cy rat kidneys , decreased expression of Bcl XL and increased expression of Bcl 2 was present at 2 weeks of age . ^^^ CONCLUSIONS : Activation of caspase 3 and dysregulation of the balance between pro and anti apoptotic Bcl 2 family members , specifically a down regulation of anti apoptotic Bcl XL , correlates with increased apoptosis in polycystic Han : SPRD rat kidneys . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The mRNA expression levels of the bcl 2 genes family was changed as follows : bax increased up to 40 % in CCI vs the sham rats , while bcl 2 did not change ; bcl xS massively decreased ( by 70 % and 100 % ) , while bcl xL increased ( by 40 % ) in CCI rats . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Antisense RNA down regulation of bcl xL Expression in prostate cancer cells leads to diminished rates of cellular proliferation and resistance to cytotoxic chemotherapeutic agents . bcl xL is a M ( r ) 26 , 000 bcl 2 homologue that is highly expressed in prostate cancer cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Furthermore , rifampicin down regulated the expression of Bax and CD95L and up regulated the expression of Bcl 2 , Bcl xL , and Flice inhibitory protein L ( FLIPL ) ; however , rifampicin had no effect on CD 95 or XIAP expression . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 , Bcl xL , and A 1 are differentially expressed during B and T cell development , and they have shared and distinct roles in regulating cell death . ^^^ Comparison with the effects of Bcl 2 and Bcl xL expressed under similar control elements supports the model that antiapoptotic Bcl 2 homologs interact differentially with intracellular pathways affecting development and apoptosis in lymphoid cells . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
IVIG decreased the intracellular expression of anti apoptotic proteins of the Bcl 2 family ( A 1 and Bcl XL ) while IVIG increased the intracellular expression of pro apoptotic proteins ( Bax and Bcl XS ) in the TNF alpha stimulated HUVECs . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Overexpression of Bcl xl , an anti apoptotic Bcl 2 family protein , completely inhibited Delta psi m disruption , caspase activation , and cell death . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In this study we found that Tat protected vincristine treated Kaposi ' s sarcoma cells from apoptosis and from down regulation of several anti apoptotic genes such as AKT 1 , AKT 2 , BCL 2 , BCL XL , and insulin like growth factor 1 and induced the de novo expression of the interleukin 3 gene . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
RANKL had no effect on H / RS cell survival in culture , and it did not modulate the expression of bcl 2 , bcl xL , bax , or inhibitors of apoptosis proteins . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
These findings suggest that modulation of MAP kinase and Akt expression , Bcl xL , Bcl xs , Bcl 2 and Bad proteins by finasteride may be , in part , responsible for the anti proliferative and apoptotic effect of this drug seen clinically and in animal models . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
High mutation levels of cell cycle control genes such as p 53 , p 16 , p 21 , SMAD 4 , and cyclin D 1 are found , and there is abnormal expression of apoptotic genes , such as bcl 2 , bcl XL , and bax . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We show that expression of the Bcl 2 family member , Bcl xL , is induced maximally by IL 4 and anti IgM / IL 4 in a Stat 6 dependent manner . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Apoptosis and expression of Bcl 2 , Bcl XL , and Bax in renal cell carcinomas . ^^^ The present study analyses the inter relationship between the expression of representatives of the anti apoptotic ( Bcl 2 , Bcl XL ) or pro apoptotic ( Bax ) Bcl 2 proteins , incidence of apoptosis , and mitosis in a selected small group of 22 graded RCCs that had paired normal renal tissue , or non neoplastic tissue in the renal biopsy specimen . ^^^ The results showed that in approximately 50 % of the RCCs , where Bcl 2 and / or Bcl XL expression was high , apoptosis was not detected , and when expression of these proteins was low or not found , increased levels of apoptosis were seen . ^^^ In most of the remaining 50 % of samples , high levels of Bcl XL but not Bcl 2 were negatively correlated with low levels of apoptosis ( Bcl XL : r = 0 . 437 , P = 0 . 07 and Bcl 2 : r = +0 . 560 , P = 0 . 02 ) . ^^^ A novel finding was an association between low expression of Bcl 2 and / or Bcl XL in normal tissue and the level of expression of these proteins in the RCCs , an intrinsic variation that may be an individual patient factor . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Analysis of ribosyl modified , mixed backbone analogs of a bcl 2 / bcl xL antisense oligonucleotide . ^^^ The ability of the 2 ' O ( 2 methoxyethylribose ) ( 2 ' MOE ) modified phosphorothioate gapmer oligonucleotide 4625 , which matches the bcl 2 mRNA and has three base mismatches to bcl xL , to inhibit bcl 2 and bcl xL expression and induce tumor cell apoptosis has been described . ^^^ The ability of the various 4625 analogs , including the parental first generation oligonucleotide 3005 , to inhibit bcl 2 and bcl xL expression , and diminish cell growth or induce tumor cell death was assessed in SW 2 lung cancer cells using real time PCR , Western blotting and cell viability assays . ^^^ Only oligonucleotide 4625 exhibited a potent bispecific antisense activity against bcl 2 and bcl xL , which effectively reduced tumor cell viability . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
MAIN OUTCOME MEASURES : We examined the expression of Bcl 2 , Bcl xl , Bax , caspase 3 , and inducible nitric oxide synthase in infiltrating mononuclear cells of colorectal cancer tissues and also in colorectal cancer tissues . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
To investigate the potential role of the BCL 2 gene family ( BAX , BCL 2 , MCL 1 , and BCL XL ) in ovarian cancer development and progression , mRNA expression levels of these genes were measured using semi quantitative PCR in epithelial ovarian tumor tissues and normal ovaries . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 , Bcl xL and c FLIP ( L ) potentially regulate the susceptibility of human peripheral blood monocyte derived dendritic cells to cell death at different developmental stages . ^^^ Antigen ( Ag ) specific and nonspecific cognate interaction with T cells failed to cause cell death of iDCs and mDCs . iDCs constitutively expressed transcripts and intracellular products of Bcl 2 and Bcl xL , but not cellular FLICE inhibitory protein ( long ( c FLIP ( L ) ) , while the increased expressions of Bcl 2 , Bcl xL and c FLIP ( L ) were observed in mDCs . ^^^ These results suggest that the selective expressions of Bcl 2 , Bcl xL and c FLIP ( L ) may be involved in the difference in the susceptibility to cell death between iDCs and mDCs . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Malignant pleural mesothelioma lines and tumors rarely express the antiapoptotic Bcl 2 protein but routinely express the antiapoptotic protein Bcl xl and the proapoptotic proteins Bax and Bak . ^^^ We have previously shown pharmacologic inhibition of bcl xl expression in malignant pleural mesothelioma can lead to apoptosis , so we sought to determine whether antisense oligonucleotides directed at bcl xl messenger RNA would engender apoptosis , possibly through a `` forced imbalance ' ' of bcl 2 family proteins . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We also found up regulation of Bcl xS in the former cell lines , and in the latter cell lines , the expressions of Bcl 2 and Bcl xL were induced simultaneously . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We have previously shown that nerve growth factor ( NGF ) induced activation of nuclear factor kappaB increased neuronal expression of Bcl xL , an anti apoptotic Bcl 2 family protein . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In addition , it counteracted the effect of TNP BSA on the expression of the Bcl 2 family , resulting in down regulation of Bax and Bad and up regulation of Bcl XL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In this study , we evaluated the expression patterns of Bcl 2 , Bcl xL , and Bax protein in 126 primary invasive breast carcinomas , and the association with other clinicopathological parameters . ^^^ Bcl 2 overexpression showed an inverse association with cyclin A ( p=0 . 05 ) , while expression of Bcl xL showed an association only with cyclin D 3 ( p=0 . 04 ) . ^^^ Bcl 2 and Bcl xL showed an association with different D type cyclins , indicating different pathways of pathogenesis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The survival genes Bcl 2 , Bcl XL , and survivin act independently and downstream of ERK and JNK to decrease the survival of TNF alpha treated RT 101 cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Engagement of the IL 2 receptor on these undivided activated T lymphocytes leads to enhanced survival and up regulation of Bcl 2 and Bcl xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Finally , over expression of Bcl 2 and its homologue Bcl xL was observed in manumycin treated cells as well as in control myeloma cells , implying that the Bcl 2 family is not involved . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Transfection efficiencies were markedly enhanced by co transfection of cells with prototypic anti apoptotic genes , such as bcl 2 and bcl xL , and supplementing the culture medium with B 27 Supplement . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Instead , G 3139 , but not NOV 2009 , induced similar changes as ODN 2006 in proliferation , expression of costimulatory and antigen presenting molecules , as well as in bcl 2 and bcl xL levels of primary B CLL cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Enhanced expression of Bax itself did not inhibit the growth rate of infected cells and did not influence expression of Bcl 2 and Bcl xL . ^^^ Caspase activation and / or an imbalance in Bax and Bcl 2 / Bcl xL expression may be the reasons for the augmentation of cytotoxicity by these drugs . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The proteins studied were Bcl 2 , Bcl xL ( anti apoptotic ) , Bax , Bad , Bak , and Bcl xS ( pro apoptotic ) . ^^^ The percentage of BMMNC expressing Bcl 2 and Bcl xL was higher in refractory anemia with excess of blasts ( RAEB ) , RAEB in transformation ( RAEB T ) , and chronic myelomonocytic leukemia ( CMML ) than in refractory anemia ( RA ) and RA with ringed sideroblasts ( RAS ) . ^^^ Higher expression of pro apoptotic Bcl 2 family proteins ( Bak , Bad , Bcl xS ) and higher Bcl xS / Bcl xL ratio were associated with longer survival and decreased risk of leukemic transformation in univariate analysis , whereas expression of anti apoptotic proteins was associated with decreased survival . ^^^ Moreover , the study of markers such as CD 34 ( or Bcl 2 ) , Bcl xL , and Bcl xS provides additional prognostic information . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Quantitative analysis of apoptosis and the apoptosis regulatory genes Bcl 2 , Bcl xL , and Bax were performed by terminal deoxynucleotidyl transferase mediated deoxyuridine triphosphate digoxigenin nick end labeling staining and real time PCR , respectively . ^^^ The apoptosis inhibitors Bcl 2 and Bcl xL were significantly up regulated in renal tubular cells of recipients without ARF compared with CAD ARF . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Nonetheless , H 460 cells stably overexpressing antiapoptotic Bcl 2 or Bcl xL did not show any protective effect from cell death induced by either drug . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The murine IL 3 dependent myeloid cell line 32D undergoes a rapid death when deprived of interleukin 3 ( IL 3 ) , a process that is suppressed or delayed by the constitutive expression of Bcl 2 or the Bcl 2 related Bcl xL survival protein . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Arginine antimetabolite L canavanine induces apoptotic cell death in human Jurkat T cells via caspase 3 activation regulated by Bcl 2 or Bcl xL . ^^^ Under these conditions , the expression of Bcl 2 and its functional homolog Bcl xL was markedly upregulated . ^^^ The L canavanine induced caspase 3 activation , degradation of PARP , and apoptotic DNA fragmentation were suppressed by ectopic expression of Bcl 2 or Bcl xL , both of which are known to play roles as anti apoptotic regulators . ^^^ These results demonstrate that the cytotoxic effect of L canavanine on Jurkat T cells is attributable to the induced apoptosis and that L canavanine induced apoptosis is mediated by a cytochrome c independent caspase 3 activation pathway that can be interrupted by Bcl 2 or Bcl xL . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In this study , using surgical specimens from 42 patients with hepatocellular carcinoma ( HCC ) , we investigated the expression and localization of Bcl xL , an antiapoptosis related protein of the Bcl 2 family . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The oncogene derived protein Bcl 2 and its family members such as Bcl xL or Mcl 1 can confer negative control in the pathway of cellular suicide machinery . ^^^ Previous reports by others and us demonstrate that phosphorylation of anti apoptotic proteins such as Bcl 2 , Bcl xL or Mcl 1 can regulate their function depending on the apoptotic trigger or cell type . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
High bad and bcl xL gene expression and combined bad , bcl xL , bax and bcl 2 mRNA levels : molecular predictors for survival of stage 2 soft tissue sarcoma patients . ^^^ Samples from 82 STS patients were analyzed for mRNA expression of bad , bax , bcl xL and bcl 2 by a high throughput quantitative RT PCR approach , using validated assays based on TaqMan technology . ^^^ Considering STS patients of tumor stage 2 , multivariate Cox analysis revealed that bad mRNA values > or = 10 ( p=0 . 0039 ; RR=9 . 08 ) , bcl xL > or = 1 . 5 ( p=0 . 067 ; RR=4 . 59 ) , bax > or = 0 . 005 ( p=0 . 1 ; RR=2 . 84 ) and bcl 2 < 3 ( p=0 . 42 ; RR=1 . 7 ) were associated with a poor prognosis . ^^^ There was a 14 . 5 fold and 6 . 5 fold increase in the risk for the combinations of high bax / bcl xL mRNA ( p=0 . 018 ) and bax / bcl 2 mRNA expression ( p=0 . 017 ) , respectively . ^^^ In conclusion , high bad mRNA levels and combined values of bad / bcl xL bax / bcl xL and bax / bcl 2 appear to be independent prognostic factors at least for stage 2 STS patients . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Jurkat cells overexpressing L35a did not have increased levels of the anti apoptotic proteins Bcl 2 or Bcl xL , the drug efflux pump P glycoprotein , nor altered cellular growth kinetics or total protein synthesis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
METHODS : Paraffin embedded archival tissue from 103 N0M0 consecutive patients with invasive bladder cancer ( 28 T 1 , 57 T 2 , 13 T 3 and 5 T 4 ) was immunostained for bcl 2 , bax , bcl XL , bcl Xs , p 53 , Ki 67 and with an anti single stranded DNA monoclonal antibody recognizing the apoptotic cells . ^^^ RESULTS : Most tumours were immunoreactive for bax ( 73 . 1 % ) and bcl XL ( 80 . 9 % ) whereas bcl 2 and bcl XS expression was comparatively less common ( 44 . 4 and 28 . 9 % , respectively ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Development of a human neuronal cell model for human immunodeficiency virus ( HIV ) infected macrophage induced neurotoxicity : apoptosis induced by HIV type 1 primary isolates and evidence for involvement of the Bcl 2 / Bcl xL sensitive intrinsic apoptosis pathway . ^^^ Apoptosis initiated by the intrinsic pathway is typically blocked by antiapoptosis Bcl 2 family proteins , such as Bcl 2 and Bcl xL , but whether these can block HIV / macrophage induced neuronal apoptosis is unknown . ^^^ N neuronal lines that overexpress Bcl 2 or Bcl xL ( NT2 . ^^^ N / bcl xL neurons were resistant to apoptosis induced by either R 5 , X 4 , or R5 / X4 isolates and that resistance was abrogated by a Bcl 2 antagonist . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
To evaluate the role of endogenous angiotensin in cardiac development , the relationship between ACE inhibition , cell proliferation , apoptosis , several modulators of apoptosis ( bcl 2 , bcl xl , and clusterin ) was examined in the developing rat heart . ^^^ Thirty five newborn rat pups were treated with enalapril ( 30 mg / kg / d ) or a vehicle ( control group ) for 7 d , and hearts were removed for rt PCR and Western blotting of bcl 2 , bcl xl , and clusterin . ^^^ Cardiac bcl 2 mRNA , clusterin mRNA , bcl 2 protein , and bcl xl protein content were not changed , but clusterin protein expression was decreased by enalapril treatment . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Immunohistochemistry was performed for Fas , Bcl 2 , Bax , Bcl xl , inducible nitric oxide synthase ( iNOS ) , and cyclooxygenase 2 ( COX 2 ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Taken together , these findings indicate that BimEL may activate Bax by damaging the mitochondrial membrane structure directly , in addition to its binding and antagonizing Bcl 2 / Bcl XL function . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Likewise , mechanical stress resulted in up regulation of anti apoptotic Bcl 2 proteins , including Bcl 2 and Bcl xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The administration of agonistic anti Fas antibody ( CH 11 ) or cycloheximide alone did not induce apoptosis , whereas the co administration of CH 11 with cycloheximide induced apoptosis in WI 38 cells , in which caspase 8 and 3 , but not 9 , were activated , and 10 chromosome linked inhibitor of apoptosis ( ILP ) and FLICE like inhibitor protein ( FLIP ( L ) ) , but not bcl xL and bcl 2 , were remarkably down regulated . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Total endothelial cell growth factor deprivation gave a significant increase in apoptosis accompanied by a decrease of Bcl 2 in apoptotic cells while Bcl xl and Bax levels were unaffected . ^^^ Our data indicate that anti apoptotic protein Bcl 2 and pro apoptotic protein Bax are reciprocally regulated during apoptosis , whilst Bcl xl is essentially unaffected . ^^^ This implies that Bcl 2 / Bax ratio rather than Bcl xl controls apoptosis in primary endothelial cells . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
BACKGROUND : Resistance to chemotherapy in glioblastoma has been linked to the expression of antiapoptotic Bcl 2 family members including Bcl xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The resistant phenotype of these clones determined by immunofluorescence and immunoblot was associated with transient expression of the beta tubulin i . v . isoform and was independent of P glycoprotein , bcl 2 and bcl xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The immunohistochemistry assay was used to detect the protein levels of Bcl 2 , Bcl xl , Bax , inducible nitric oxide synthase ( iNOS ) , neuronal NOS ( nNOS ) , and cleaved caspase 3 . ^^^ Moreover , Rg 1 elevated the levels of cleaved caspase 3 , Bax , and iNOS , but reduced the levels of Bcl 2 and Bcl xl ( P < 0 . 01 ) . ^^^ CONCLUSION : Rg 1 has protective effect against MPTP induced apoptosis and this effect may be attributed to enhancing Bcl 2 and Bcl xl expression , reducing Bax and iNOS expression , and inhibiting activation of caspase 3 . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Cell survival indices including proliferating cell nuclear antigen ( PCNA ) , Bcl 2 , Bcl xL and Bax were measured by immunohistochemistry and Western blots . ^^^ Bcl 2 was enhanced in the HGF transfected UUO rats , while no changes of Bcl xL and Bax were found . ^^^ Bcl 2 rather than Bcl xL or Bax may contribute to the anti apoptotic function of HGF . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The ability of CpG ODN to protect T cells from these forms of death was associated with the up regulation of antiapoptotic gene products including c FLIP , bcl xL , and , to some extent , bcl 2 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Western blot analysis showed that HepG 2 cells contain a very low level of Bcl 2 and a much higher level of Bcl XL , another antiapoptotic factor of the same family . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Proapoptotic BAD ( Bcl 2 associated death protein ) has been shown to dissociate from its sequestered site with the molecular chaperone protein 14 3 3 and displace proapoptotic BAX ( Bcl 2 associated 10 protein ) from antiapoptotic BCL Xl . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
On the other hand , Trp P 1 upregulated anti apoptotic factors Bcl 2 and Bcl XL and downregulated pro apoptotic factor Bax in mitochondria 1 hr after injection , indicating that Trp P 1 also stimulated anti apoptotic signals . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The Bcl 2 , Mcl 1 , Bcl xL / S , Bcl w , Bax , Bak , and Bad were shown to be expressed in both malignant and non neoplastic , normal plasma cells . ^^^ Furthermore , the anti apoptotic proteins Bcl 2 , Mcl 1 and Bcl xL were down regulated , while the expression of the pro apoptotic Bax protein was increased . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
This effect was accompanied by inhibition in the expression of the antiapoptotic proteins bcl xL and bcl 2 , and by a suppression of the activated ( phosphorylated ) form of akt protein . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Overexpression of Bcl xL , an anti apoptotic member of the Bcl 2 family , negatively correlates with the sensitivity of various cancers to chemotherapeutic agents . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
G ( 2 ) M arrest was associated with phosphorylation of Bcl 2 ( but not BAD , Bax , or Bcl XL ) : both of these end points were abrogated by treatment with a calcium chelator . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Using reverse transcription polymerase chain reaction ( RT PCR ) and Western blot analysis , we found that brimonidine can up regulate the expression of basic fibroblast growth factor , bcl 2 and bcl xl in the retina . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The status of antisense targeting of genes relevant to prostate cancer , including bcl 2 , bcl xL , clusterin , androgen receptor ( AR ) and IGFBPs , are reviewed . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Expression and significance of bcl 2 and bcl xL in rat neuron after acute brain trauma ] . ^^^ OBJECTIVE : To observe the expression of bcl 2 and bcl xL in rat brain neuron after acute brain trauma . ^^^ The expression of bcl 2 and bcl xL in rat brain neuron was examined by immunohistochemical staining . ^^^ RESULTS : There were few bcl 2 ( cortex : 4 . 40 + / 1 . 67 , hippocampal : 3 . 20 + / 1 . 30 ) and lots of bcl xL ( cortex : 45 . 60 + / 4 . 34 , hippocampal : 50 . 20 + / 3 . 50 ) expression in normal controls . ^^^ CONCLUSIONS : bcl 2 expression increased after acute brain trauma but bcl xL did not change much . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Up regulation of Bcl XL , but not of other Bcl 2 family proteins , was associated with the suppression of functional Ik 2 by Ik 6 in a dominant negative fashion . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
To clarify the subcellular mechanisms of age associated dysregulation of apoptosis and the effects of CR , we analyzed the expression of genes promoting apoptosis ( p 53 , Fas receptor , Fas ligand , TNF receptor 1 , TNFalpha , Bax , TGF beta 1 ) and genes preventing apoptosis ( Bcl 2 and Bcl XL ) in the livers of 3 , 6 , 15 , and 24 month old male F 344 rats that were either fed ad libitum or subjected to a 30 % reduction in food intake ( CR ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
MM cells express multiple Bcl 2 family members , including Bcl 2 , Bcl XL , and Mcl 1 , which are thought to play a key role in the survival and drug resistance of myeloma . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Effect of bax , bcl 2 and bcl xL on regulating apoptosis in tissues of normal liver and hepatocellular carcinoma . ^^^ AIM : To investigate the expression of bax , bcl 2 and bcl xL mRNA in the tissues of normal liver and hepatocellular carcinoma ( HCC ) , and analyze the relationship between the expression of bax , bcl 2 and bcl xL mRNA and clinical parameters of HCC patients . ^^^ METHODS : The expression of bax , bcl 2 and bcl xL mRNA of normal liver and HCC was measured by Northern blot . ^^^ RESULTS : A very low mRNA level was indicated at bax , bcl 2 and bcl xL in the HCC tissues in contrast to the tissues of normal liver by Northern blot analysis . ^^^ The analyses of mRNA level revealed that HCC tissues exhibited a mean 7 . 6 fold decrease in bax , 4 . 2 fold in bcl 2 and 3 . 5 fold in bcl xL in comparison with normal control tissues , respectively . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The bcl xl , similar to bcl 2 , inhibits apoptosis , whereas bcl xs counters the effects of bcl 2 and bcl xl . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
A decrease in the anti apoptotic protein , Mcl 1 , was detected in emodin treated HL 60 cells , whereas other Bcl 2 family proteins including Bax , Bcl 2 , Bcl XL , and Bad remained unchanged . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 / bcl xL bispecific antisense treatment sensitizes breast carcinoma cells to doxorubicin , paclitaxel and cyclophosphamide . ^^^ Overexpression of the anti apoptotic proteins bcl 2 and bcl xL is implicated in breast cancer development , tumor progression and drug resistance . ^^^ Here we describe the use of the bcl 2 / bcl xL bispecific antisense oligonucleotide 4625 to sensitize breast carcinoma cells to anti cancer drugs routinely used in breast cancer therapy . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In primary hippocampal cultures neuroprotection by NGF against glutamate toxicity was mediated by NF kappaB and accompanied by an increased expression of neuroprotective NF kappaB target genes Bcl 2 and Bcl xl . ^^^ Moreover , neuroprotection by NGF against glutamate toxicity was abolished in p75NTR / neurons , and the expression of bcl 2 and bcl xl was markedly reduced as compared to wildtype cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
CDDO Me did not alter the level of Bcl 2 and Bcl xL proteins , and no correlation was found between cell sensitivity to CDDO Me and basal Bcl 2 expression level . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In 30 consecutive children with ALL treated with prednisone we determined changes in the expression of Bcl 2 , Bax and Bcl xl proteins in leukemic lymphoblasts and related these to clinical features and rate of prednisone induced apoptosis . ^^^ At diagnosis , we detected expression of Bcl 2 and Bcl xl protein in 28 samples , while Bax expression protein was detected in 21 of the 30 patients . ^^^ Prednisone treatment induced a decrease in Bcl 2 and Bcl xl levels in 17 and 16 of the 28 patients , respectively , while Bax protein increased in 14 of the 21 patients . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Pro death Bax increased , whereas anti death Bcl 2 and Bcl XL decreased , and apoptotic TUNEL positive cells were detected in the hippocampus of klotho mutant mice at the age of 7 wk . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Our aim in this study is to investigate which anti apoptotic Bcl 2 family proteins ( Bcl 2 , Bcl XL , Mcl 1 ) and which signal transduction pathway ( JAK / STAT , Ras / MAPK , PI 3K / Akt ) can mediate the anti apoptotic effect of IL 6 on a human myeloma cell line XG 7 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
H 1 A extracted from Cordyceps sinensis suppresses the proliferation of human mesangial cells and promotes apoptosis , probably by inhibiting the tyrosine phosphorylation of Bcl 2 and Bcl XL . ^^^ Using immunoprecipitation and immunoblotting , we found that H 1 A inhibits tyrosine phosphorylation of human mesangial proteins and that Bcl 2 and Bcl XL were probably among these proteins . ^^^ H 1 A may be effective in the management of autoimmune disorders , and the modulation of the signal transduction proteins Bcl 2 and Bcl XL may represent a target for future pharmacologic interventions . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
METHODS : The expression of apoptosis associated proteins ( bcl 2 , bcl xL , bax , bcl xs ) , the activity of caspase 3 and cleavage of poly ADP ribose polymerase ( PARP ) were determined with Western blot analysis in the cisplatin resistant cell ( COC1 / DDP ) and cisplatin sensitive human ovarian cancer cell ( COC 1 ) . ^^^ RESULTS : The expression of bcl 2 and bcl XL in COC1 / DDP cell was significantly higher than that in COC 1 cell , whereas the expression of bax showed no change in COC1 / DDP and COC 1 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Electrophoresis and Western blotting were used to analyze DNA fragmentation and expression of DNA fragmentation factor ( DFF 45 ) , Bcl 2 , Bcl xL and Bax genes respectively . ^^^ The anti apoptotic genes Bcl 2 and Bcl xL were down regulated and the pro apoptotic gene Bax was expressed at higher levels compared with the euthyroid state . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Treatment with G 3139 led to a sequence specific reduction of Bcl 2 protein levels within 4 days of exposure in 10 out of 11 clinical samples from patients with chemosensitive and multidrug resistant disease , without significant reduction of alpha Actin , Bax , Bcl XL , or Mcl 1 proteins . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Apo2L / TRAIL induced the expression of pro apoptotic proteins , Bad and Bax ; downregulated the anti apoptotic proteins , Bcl 2 and Bcl xL ; and activated caspases 3 , 7 , 8 , 9 and 10 . ^^^ Cisplatin / Apo2L / TRAIL combination resulted in further downregulation of expression of anti apoptotic proteins , Bcl 2 and Bcl xL , as well as an increase in mitochondrial permeability transition and activation of caspases 3 , 8 , and 10 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Stronger correlation of bcl 3 than bcl 2 , bcl xL , costimulation , or antioxidants with adjuvant induced T cell survival . ^^^ Flow cytometric stains for antiapoptotic Bcl 2 and Bcl xL showed that neither factor was well correlated with AIS , although both were increased transiently upon T cell activation . ^^^ It is proposed that T cell survival during productive immune responses occurs by successive activities of Bcl 2 , Bcl xL and Bcl 3 , with Bcl 3 requiring innate immune responses to adjuvants for its expression . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The sensitization observed by these inhibitors correlated with the inhibition of Bcl 2 expression in 2F7 and Bcl xL expression in U 266 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Down regulation of Bcl 2 and Bcl xL expression with bispecific antisense treatment in glioblastoma cell lines induce cell death . ^^^ The functions of the antiapoptotic proteins Bcl 2 and Bcl xL were examined in glioblastoma cells . ^^^ Expression of both Bcl 2 and Bcl xL were found to be elevated in protein lysates from seven early passage cell lines derived from human glioblastoma tumors compared with non neoplastic glial cells . ^^^ Down regulation of both bcl 2 and bcl xL expression in glioblastoma cell lines U 87 and NS 008 with bcl 2 / bcl xL bispecific antisense oligonucleotide resulted in spontaneous cell death . ^^^ Executioner caspase 6 and caspase 7 , but not caspase 3 , were involved in apoptosis induced by bcl 2 / bcl xL antisense treatment . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Combined targeted inhibition of bcl 2 , bcl XL , epidermal growth factor receptor , and protein kinase A type 1 causes potent antitumor , apoptotic , and antiangiogenic activity . ^^^ PURPOSE : This study investigated whether the functional and structural interactions between epidermal growth factor receptor ( EGFR ) , protein kinase AI ( PKAI ) , and bcl 2 / bcl xL could be exploited to obtain cooperative antitumor effects against models of human colon and breast cancer . ^^^ EXPERIMENTAL DESIGN : Antisense bcl 2 / bcl xL ( 4625 ) , antisense PKAI ( AS PKAI ) , and ZD 1839 ( `` Iressa ' ' ) , a selective EGFR tyrosine kinase inhibitor , were administered as single agents and in combination against GEO colon and ZR 75 1 breast cancer cell lines in vitro and to mice bearing s . c . ^^^ RESULTS : Antisense bcl 2 / bcl xL inhibited the growth of GEO and ZR 75 1 cells in vitro , reducing bcl 2 and bcl xL expression and vascular endothelial growth factor secretion . ^^^ Antisense bcl 2 / bcl xL , AS PKAI , and ZD 1839 administered in vivo as single agents caused growth inhibition of GEO xenografts . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Phytosphingosine induced mitochondrial translocation of Bax from the cytosol without changes in the protein levels of Bcl 2 , Bcl xL , and Bax . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Sequential analyses were made following ethanol exposure on these two postnatal days , with assessments of NTFs nerve growth factor ( NGF ) , brain derived neurotrophic factor ( BDNF ) , neurotrophin 3 ( NT 3 ) , and neurotrophin 4 ( NT 4 ) ; apoptosis related proteins Bcl 2 , Bcl xl , Bax , Akt and c jun N terminal kinase ( JNK ) ; antioxidants superoxide dismutase , glutathione reductase and catalase ; and ROS . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Interestingly , coexpression of the death antagonists Bcl xL and Bcl 2 significantly increased their oncogenicity , whereas other NF kappaB regulated death inhibitors showed little or no effect . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The effect of IFN a is not accompanied by a modulation of CD 95 , CD95L , p 53 , p 21 ( WAF 1 ) , p 27 , bcl 2 , bcl xL , bax , NFkappaB , or IkappaB gene expression . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In addition , the anti apoptotic genes , bcl 2 and bcl xL , were expressed at increased levels in AD patients . ^^^ Expression of bcl 2 and bcl xL was also increased after stimulation with IL 5 , IL 4 or IFN gamma . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The intracellular quantity of the inducible anti apoptotic gene Bcl xL product was significantly higher in the pulmonary lymphocytes of HP patients than in lymphocytes of the control , while no difference was found for constitutive anti apoptotic protein ( Bcl 2 ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Regulation of 17 AAG induced apoptosis : role of Bcl 2 , Bcl XL , and Bax downstream of 17 AAG mediated down regulation of Akt , Raf 1 , and Src kinases . 17 allylamino demethoxy geldanamycin ( 17 AAG ) inhibits the chaperone function of heat shock protein 90 ( Hsp 90 ) and promotes the proteasomal degradation of its misfolded client proteins . ^^^ In addition , in HL 60 / Bcl 2 and HL 60 / Bcl xL cells , which ectopically express Bcl 2 and Bcl xL respectively , 17 AAG induced Bax conformational change , cytosolic accumulation of cyt c and Smac / DIABLO , and apoptosis were markedly inhibited . ^^^ Although the rate of 17 AAG mediated decline in Akt , c Raf 1 , and c Src levels was blunted , the total decline was not compromised in HL 60 / Bcl 2 and HL 60 / Bcl xL cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
High toxic concentration of DA ( 500 microM ) , R APO ( 50 microM ) , melatonin ( 50 microM ) , and EGCG ( 50 microM ) exhibited a similar profile of proapoptotic gene expression , increasing the level of bax , caspase 6 , fas ligand , and the cell cycle inhibitor gadd 45 genes , while decreasing antiapoptotic bcl 2 and bcl xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Apoptotic process of Caki 2 cells was associated with the changes of Bcl 2 , Bcl XL , caspase 9 , caspase 3 , caspase 7 proteins as well as mitochondria transmembrane potential ( DeltaPsim ) loss . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
This was mediated by an increased expression of the antiapoptotic proteins Bcl 2 and Bcl xL . ^^^ Inhibition of the GLP 1 dependent increase of cAMP by Rp cAMP blocked the antiapoptotic action of GLP 1 , as determined by DNA fragmentation and poly ( ADP ribose ) polymerase assays and by detection of Bcl 2 and Bcl xL protein levels . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The status of antisense targeting of several genes , including bcl 2 , bcl xL , clusterin , androgen receptor and IGFBPs , relevant to prostate and other cancers , are reviewed . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
These two mutants still retained the ability to interact with wild type Bcl 2 and Bcl xL , and abrogated the inhibitory effect of wild type Bcl 2 or Bcl xL on Bax or Bak induced apoptosis . ^^^ Taken together , our results demonstrate that Bcl 2 / DeltaBH1 or Bcl 2 / G145A acts as a dominant negative of endogenous anti apoptotic proteins such as Bcl 2 and Bcl xL , thereby enhancing antitumor drug induced apoptosis , and that this dominant negative activity requires both a failure of interaction with Bax and Bak through the BH 1 domain of Bcl 2 and retention of the ability to interact with Bcl 2 and Bcl xL . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The cytosolic domain of BCL w consists of 8 alpha helices , which adopt a fold similar to that of BCL xL , BCL 2 , and BAX proteins . ^^^ These results suggest that although the cytosolic domain of BCL w exhibits an overall structure similar to that of BCL xL and BCL 2 , the unique organization of its C terminal helix may modulate BCL w interactions with pro apoptotic binding partners . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Whether conventional hypothermic CPB induces myocyte apoptosis in dog hearts and modulation of bcl 2 , bcl xl , bax , bad , and caspase 3 pathways in this setting was investigated . ^^^ Immunohistochemistry and flow cytometry were employed for detection of expressions of bcl 2 , bcl xl , bax and bad proteins . ^^^ The results of immunohistochemistry demonstrated that bcl 2 , bcl xl , bax and bad proteins were constitutionally present on the sarcolemma of the LV myocytes . ^^^ FACS results showed that , after CPB , expressions of bax and bad in CPB group were significantly upregulated , while the expressions of bcl 2 and bcl xl were not significantly changed in both groups . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Polymerase chain reaction ( PCR ) based transcriptional patterning confirmed the increased expression of Nix during human erythropoiesis with a pattern similar to that of Bcl xL and glycophorin A and opposite that of Bcl 2 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Western blot analysis of Bcl 2 , Bcl xL , Bad , Caspase 3 , PDK 1 , and phospho Akt also revealed SOD mediated changes in gene expression consistent with protection and decreased apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
BH 3 containing peptides induce apoptosis by binding to the hydrophobic pocket of the anti apoptotic proteins , such as Bcl 2 or Bcl XL . ^^^ Exogenous Bcl 2 or Bcl XL neutralized BH3I 2 ' in vitro and diminished its effect on the inner mitochondrial membrane . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The study aim was to investigate Stat 3 activation in a series of multiple myeloma ( MM ) cases and its effect on downstream targets such as the anti apoptotic proteins Bcl xL , Mcl 1 , and Bcl 2 , and the cell cycle protein cyclin D 1 . ^^^ Immunohistochemistry was performed on paraffin sections using antibodies against cyclin D 1 , Bcl 2 , Bcl xL , Mcl 1 , p 21 , Stat 3 , and Stat 3 phosphorylated ( P ) . ^^^ In contrast to Bcl xL and Mcl 1 , the expression of Bcl 2 showed an inverse correlation with proliferation rate ( P : 0 . 0003 ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
METHODS : Assessments were made of neurotrophic factors nerve growth factor , brain derived neurotrophic factor , neurotrophin 3 , and neurotrophin 4 ; apoptosis related proteins Bcl 2 , Bcl xl , Bax , Bcl xs , Bad , phosphorylated Bad , phosphorylated Akt , and phosphorylated c Jun N terminal kinase ; and the antioxidants superoxide dismutase , glutathione reductase , and catalase . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
BCL 2 and BCL XL restrict lineage choice during hematopoietic differentiation . ^^^ A prominent feature of these soluble factors is promotion of cell survival , in part mediated by expression of either of the anti apoptotic proteins , BCL 2 and BCL XL . ^^^ To investigate the latter possibility , we analyzed factor dependent cell Patersen ( FDCP ) Mix multipotent progenitor cells in which we stably expressed BCL 2 or BCL XL . ^^^ Thus , IL 3 deprived FDCP Mix BCL 2 cells differentiated exclusively to granulocytes and monocytes / macrophages , whereas FDCP Mix BCL XL cells became erythroid . ^^^ FDCP Mix BCL 2 cells grown in IL 3 were distinguished from FDCP Mix and FDCP Mix BCL XL cells by a striking reduction in cellular levels of Raf 1 protein . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Since Bcl 2 family proteins are key regulators of apoptosis , we examined the effects of H2O2 on the expression of principal Bcl 2 family proteins ( Bcl 2 , Bcl xL , Bax , Bad ) in neonatal rat cardiac myocytes . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 expression is markedly increased in TGF beta 1 treated pre B cells , whereas cellular FLICE like inhibitory protein long ( c FLIPL ) , Bcl XL , Bax , and Bad expression remains unchanged . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Immunohistochemical examination showed higher expression of antiapoptotic Bcl 2 , Bcl XL , survivin , and the transcription factor , NF kappaB , in the recurrent tumor than in the adjoining normal tissue . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In contrast to Bcl xL , Bcl 2 expression levels are similar in both cells lines , and do not respond to serum stimulation , suggesting that Bcl 2 may not play a physiological role in antagonizing apoptosis signals pertinent to BAD activation in prostate cancer cells . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The expression of p 53 , p 21 , Bcl 2 , Bax , Bcl xL , and Bcl xS in the 22 HCC cases detected by western bioting was quantified with a densitometer . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
RESULTS : We show that CD34+ AML fractions are more resistant to apoptosis than are corresponding CD 34 AML fractions , and that this is paralleled by higher Bcl 2 , Bcl xL , Mcl 1 , Pgp and lower Bax expression levels . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Hypoxia induced cell cycle arrest at the G0 / G1 phases and massive cell apoptosis after 24 hours through a reduction in the Bcl 2 to Bax ratio , downregulation of Bcl XL and Mcl 1 , and upregulation of caspase 3 and caspase 8 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The association between increased bcl 6 expression and enhanced apoptosis might be due , at least in part , to the null / low bcl 2 expression because previous in vitro data showed that bcl 6 overexpression induces apoptosis accompanied by bcl 2 and bcl xl downregulation . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The present study investigated expression levels of the anti apoptotic proteins BCL 2 , BCL XL and MCL 1 and the pro apoptotic proteins BAX and BCL XS in a series of 112 peripheral T cell lymphomas ( PTCLs ) classified according to the WHO classification . ^^^ Using immunohistochemical methods and a 10 % cut off , each protein was detected in a subset of PTCLs : BCL 2 in 46 % , BCL XS in 49 % , BAX in 57 % , BCL XL in 57 % , and MCL 1 in 65 % . ^^^ The proliferation index , assessed by the MIB 1 antibody , correlated with expression levels of MCL 1 ( R = 0 . 42 , p = 0 . 003 ) , BCL 2 ( R = 0 . 32 , p = 0 . 027 ) , BAX ( R = 0 . 33 , p = 0 . 014 ) , and BCL XL ( R = 0 . 34 , p = 0 . 015 ) ( Spearman rank ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
This study examined cutaneous T cell lymphoma ( CTCL ) cell lines and cutaneous lesions for the presence of Bcl 2 gene family members and found that the two apoptosis inhibiting members Bcl xL and Mcl 1 and the two apoptosis supporting members Bad and Bax were expressed . ^^^ The expression of Bcl 2 , Bcl xL , and Mcl 1 may therefore be sufficient to guarantee the survival of malignant CTCL cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Oxidative stress induced early apoptosis was linked to its ability to inhibit not only the expression of Bcl 2 and Bcl XL but the production of antioxidant enzymes as well and to stimulate Bad expression . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Overexpression of Bcl 2 or Bcl xL inhibited TRAIL induced apoptosis , growth inhibition , and loss in clonogenic survival . ^^^ Bcl 2 and Bcl xL , but not DNC 8 , inhibited TRAIL induced Bax activation . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Overexpression of anti apoptotic members of the Bcl 2 family such as Bcl 2 and Bcl XL has been implicated in cancer chemoresistance , whereas high levels of pro apoptotic proteins such as Bax promote apoptosis and sensitize tumor cells to various anticancer therapies . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
It is well established that high expression of the antiapoptotic Bcl 2 family proteins Bcl 2 and Bcl xL can significantly contribute to chemoresistance in a number of human malignancies . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Effects of soy isoflavones on apoptosis induction and G 2 M arrest in human hepatoma cells involvement of caspase 3 activation , Bcl 2 and Bcl XL downregulation , and Cdc 2 kinase activity . ^^^ In addition , isoflavone cytotoxicity correlated with downregulation of Bcl 2 and Bcl XL expression . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Different expression patterns of Bcl 2 , Bcl xl , and Bax proteins after sublethal forebrain ischemia in C57Black / Crj6 mouse striatum . ^^^ Although changes in the expression of apoptosis related proteins ( Bcl 2 , Bcl xl , and Bax ) have been considered to be crucially important in ischemic injury , the roles these proteins play in ischemic preconditioning induced by sublethal forebrain ischemia have not been elucidated . ^^^ Therefore , we investigated the transcription and expression of Bcl 2 , Bcl xl , and Bax in striatum of mice subjected to sublethal forebrain ischemia and lethal ischemia , with or without ischemic preconditioning . ^^^ Transcription and expression of Bcl 2 and Bcl xl were increased after sublethal forebrain ischemia , which attenuated the DNA fragmentation induced by lethal ischemia . ^^^ CONCLUSIONS : Upregulation of Bcl 2 and Bcl xl but not Bax may have a role in protective ischemic preconditioning . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The expressions of Fas and Bcl 2 family genes ( Bax , Bcl 2 , Bcl xL , Bcl xS ) were not affected by NS 398 treatment in all three cell lines . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Induction of apoptosis and chemosensitization of mesothelioma cells by Bcl 2 and Bcl xL antisense treatment . ^^^ Our study was designed to investigate the role of the anti apoptotic proteins Bcl 2 and Bcl xL in the chemoresistance of cells derived from malignant pleural mesothelioma . ^^^ First , we determined the basal expression levels of Bcl 2 and Bcl xL in mesothelioma cells and examined the effect of their downregulation by antisense oligonucleotides . ^^^ Bcl xL mRNA and protein could be readily detected in mesothelioma cell lines , whereas only low levels of Bcl 2 mRNA and protein were found . ^^^ Preferential downregulation of either Bcl xL alone or of Bcl xL and Bcl 2 simultaneously was achieved by treatment with antisense oligonucleotides 4259 and 4625 , respectively , whereas the expression of other apoptosis relevant genes remained unaffected . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Curcumin causes dose dependent apoptosis and DNA fragmentation of Caki cells , which is preceded by the sequential dephosphorylation of Akt , down regulation of the anti apoptotic Bcl 2 , Bcl XL and IAP proteins , release of cytochrome c and activation of caspase 3 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl xL is an antiapoptotic member of the Bcl 2 family , which inhibits apoptosis initiated by various cellular stresses , and has a pivotal role in the survival of tumor cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
CD44v7 deficiency was characterized by an increase in the percentage of apoptotic cells after stimulation , increased numbers of CD95L and CD 152 positive cells , low levels of the anti apoptotic proteins Bcl 2 and Bcl Xl , and decreased phosphorylation of the pro apoptotic protein BAD . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Unlike Bcl 2 , Bak stimulates several apoptosis pathways , and by interacting with Bcl 2 or Bcl XL , it counteracts the anti cell death effect . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Here we show that codelivery of DNA encoding inhibitors of apoptosis ( BCL xL , BCL 2 , XIAP , dominant negative caspase 9 , or dominant negative caspase 8 ) with DNA encoding model antigens prolongs the survival of transduced DCs . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Remarkably , these events occurred in the absence of any reduction in the expression of the Bcl 2 family members Bcl 2 , Mcl 1 , and Bcl xL or any change in the proapoptotic molecules Bad or Bax . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Signal transduction through CD 40 rescues Ramos BL B cells from AgR and ionomycin triggered apoptosis at a very early stage of the apoptotic process by inhibiting both the early cleavage of PARP as well as the activation of caspase 3 , 7 and 8 and cleavage of lamin B 1 ; CD 40 mediated rescue occurs upstream of CD 40 induced expression of Bcl 2 and increased expression of Bcl xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
It was reported that SCF / c kit , Bcl 2 and Bcl xl inhibited the apoptosis while caspase 3 , Fas , Bax and clusterine stimulated it . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
A decrease in the anti apoptotic protein , Mcl 1 , was detected in QUE treated HL 60 cells , whereas other Bcl 2 family proteins including Bax , Bcl 2 , Bcl XL , and Bag remained unchanged . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
AIMS : To correlate the expression of a series of apoptotic and oncogene markers ( including p 53 , Bcl 2 , BAX , Bcl XL , p21WAF , 1 / CIP1 , cyclin D 1 , HER 2 / neu ) in thymic epithelial tumours with histological type , stage and resectability and to determine whether the information on HER 2 / neu would be valuable in identifying patients who are eligible for anti HER 2 / neu treatment . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Selegiline and its metabolite , desmethylselegiline , reduce apoptosis by altering the expression of a number of genes , for instance , superoxide dismutase , Bcl 2 , Bcl xl , NOS , c Jun , and nicotinamide adenine nucleotide dehydrogenase . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We demonstrated that Dox and Taxol induced apoptosis through down regulation of XIAP and phosphorylation of Bcl 2 in a concentration dependent manner without changing expression of Bcl xL in H 460 cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The apoptotic pathways thought to be employed by epidermal keratinocytes in the various cell layers are reviewed , with special emphasis on the protective mechanisms such as proto oncogenes bcl 2 and Bcl XL , growth factors , and the NFkB pathway in protecting keratinocytes from premature apoptosis during the process of upward migration and differentiation . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The analysis of the bcl 2 family of proteins demonstrates that bcl 2 , bax and bcl XL are involved in triggering apoptosis in spheroids exposed to 5 Gy . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Our present results suggest that in contrast to BCL 2 , transient expression of BCL xL does not induce cell death and coexpression of BCL xL with the pro apoptotic BCL 2 does not suppress cell death . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
A pro apoptotic protein Bax is a Bcl 2 family member and forms homodimers and also heterodimerizes with death antagonists , Bcl 2 and Bcl XL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
METH induced apoptotic cell death and mRNA expression of pro apoptotic proteins ( bax and DP 5 ) , but not anti apoptotic proteins ( bcl 2 and bcl XL ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
These changes in the Fas Fas ligand pathway and Bcl 2 mitochondrial apoptosis regulation are enhanced by complete suppression of antiapoptotic FADD like IL 1beta converting enzyme inhibitory protein ( FLIP ) ( from 30 . 5 to 0 . 0 % , P < 0 . 01 ) and Bcl xL ( from 22 . 5 to 0 . 1 % , P = 0 . 03 ) expression among these cells from the earliest days after gene transfer . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Cytotoxicity , expression of genes encoding BCL 2 , BCL XL , SMAC , APAF 1 proteins and caspases 3 and 9 , the activity of caspases 3 and 9 and apoptosis induction were studied . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Activation of CD 4 ( + ) or CD 8 ( + ) T cells by antigenic peptides induced an early but transient IL 2 independent expression of A 1 and Bcl xl mRNA and proteins , whereas expression of Bcl 2 was delayed and required IL 2 . ^^^ Therefore , in naive , activated and posteffector T cells , expression of A 1 is dependent on TCR but not on cytokine receptor engagement , indicating that A 1 is differently regulated from Bcl xl and Bcl 2 . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
These biochemical changes were associated with apoptosis in both cell lines that was coupled with activation of caspase 3 and decreased bcl xL and bcl 2 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Expression of Bcl 2 and Bcl xL in cutaneous and bone marrow lesions of mastocytosis . ^^^ To investigate whether an altered regulation of mast cell apoptosis might be involved in the pathogenesis of mastocytosis , expression of the apoptosis preventing molecules bcl 2 and bcl xL was studied by immunohistochemistry in skin and bone marrow lesions of mastocytosis patients . ^^^ In addition , reverse transcription polymerase chain reaction was used to investigate levels of bcl 2 and bcl xL mRNA in cutaneous mastocytosis lesions . ^^^ Since activating mutations of c kit are known to be associated with some forms of mastocytosis , human mast cell cultures were also stimulated via c kit and the expression of bcl 2 and bcl xL was assessed by immunoblotting . ^^^ In patients with mastocytosis , the expression of bcl 2 protein but not bcl xL in cutaneous mast cells was significantly enhanced , compared to healthy controls . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
AIMS : To investigate whether specific patterns in the expression of apoptosis related proteins correlate with carcinoma type and / or prognosis METHODS : The expression of Fas , Bcl 2 , Bax , Bcl xl , cyclooxygenase 2 ( COX 2 ) , and inducible nitric oxide synthase ( iNOS ) was studied immunohistochemically and the extent of apoptosis and proliferation was investigated in 11 cases of intestinal type and in eight cases of diffuse type carcinoma . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Changes in the expression of two anti apoptotic proteins , bcl 2 and bcl xL , and one pro apoptotic protein , apoptotic protease activating factor 1 ( Apaf 1 ) , were examined . ^^^ Genistein alone or cisplatin alone generally did not alter bcl 2 expression or bcl xL expression , but slightly increased Apaf 1 in some cell lines . ^^^ The combined treatment with genistein and cisplatin significantly reduced bcl 2 and bcl xL protein and increased Apaf 1 protein expression . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 and Bcl xL overexpression inhibits cytochrome c release , activation of multiple caspases , and virus release following coxsackievirus B 3 infection . ^^^ Enforced Bcl 2 and Bcl xL expression markedly reduced release of cytochrome c , presentation of the mitochondrial epitope 7A6 , and depressed caspase activation following infection . ^^^ In comparison , cell death using TRAIL ligand caused caspase 8 processing prior to cytochrome c release and executioner caspases and cell death was only partially rescued by Bcl 2 and Bcl xL overexpression . ^^^ Bcl 2 or Bcl xL overexpression or zVAD . fmk treatment delayed the loss of host cell viability and decreased progeny virus release following infection . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Further , Ad NBK induced cell death is inhibited by Bcl 2 or Bcl xL gene transfer . ^^^ Interestingly , Bcl 2 and Bcl xL transfected glioma cells , which are partially protected from Ad NBK induced cell death , accumulate much higher levels of NBK than are ever observed in control infected cells . ^^^ This indicates that complex formation with Bcl 2 or Bcl xL sequesters NBK in an inactive form and that free NBK , rather than an NBK mediated depletion of free antiapoptotic Bcl 2 family proteins , is the proximate mediator of Ad NBK induced cell death . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In contrast , there was no change detected in Fas , Fas associated death domain , Bcl 2 , Bcl xl , Bax , p 53 , or XIAP ( 10 linked inhibitor of apoptosis protein ) expression up to 12 h after poly ( 1 : C ) transfection . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We next established if IL 3 and FL activated antiapoptotic Bcl 2 and the related genes Bcl XL and Mcl 1 . ^^^ By RNA protection assay and Western blot analysis , we show that all three genes are induced by IL 3 , whereas FL induces Bcl 2 and to some extent Bcl XL . ^^^ The addition of LY 294002 did not affect the expression of Bcl 2 and Bcl XL , and thus , we conclude that expression of antiapoptotic Bcl 2 family member genes is not dependent on PI 3 kinase activity . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Overexpression of Hsp 10 and Hsp 60 increased the abundance of the anti apoptotic Bcl xl and Bcl 2 , and reduced the protein content of the pro apoptotic Bax . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Modulation of synaptic transmission by the BCL 2 family protein BCL xL . ^^^ The anti apoptotic BCL 2 family protein BCL xL is highly expressed in the adult brain and localizes to mitochondria in the presynaptic terminal of the adult squid stellate ganglion . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Prognostic significance of bcl xL gene expression and apoptotic cell counts in follicular lymphoma . bcl xL , a member of the Bcl 2 family , exerts an antiapoptotic effect on lymphocytes . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
TUNEL analysis revealed a significant reduction in apoptosis in the HGF group ( 3 . 42+ / 0 . 83 % versus 8 . 36+ / 1 . 16 % , P < 0 . 01 ) , which correlated with increased Bcl 2 and Bcl xL expression in the HGF animals . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Protective properties of Bcl 2 and Bcl XL . ^^^ The nature of the control exerted by Bcl 2 and Bcl XL on such a pathway is not precisely known . ^^^ Overexpression of Bcl 2 and Bcl XL or N acetyl DEVD aldehyde treatment not only prevented the mitochondrial membrane potential decrease , but also protected cells from the apoptosis directly induced by cytochrome c electroloading . ^^^ Bcl 2 and Bcl XL protection is based on the inhibition of the caspase dependent retroactive pathway affecting the mitochondrial compartment . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Pc 4 PDT photodamages Bcl 2 and Bcl xL , antiapoptotic proteins interacting with the permeability transition pore complex that forms at contact sites between the inner and outer mitochondrial membranes . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Analysis of the expression of the members of the Bcl 2 family indicated that the synthetic glucocorticoid increased Bax protein levels without affecting the levels of Bcl 2 , Bcl XL , Bcl XS , or Bak . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
A decrease in the anti apoptotic protein , Mcl 1 , was detected in HT and NE treated HL 60 cells , whereas other Bcl 2 family proteins including Bax , Bcl 2 , Bcl XL , and Bag remained unchanged . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
To explain this intriguing differential sensitivity between unstimulated CD34+ cells versus those stimulated by Epo + KL , we examined the expression of apoptosis regulating genes ( FLIP , BCL 2 , BCL XL , BAD and BAX ) in these cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
These events were associated with Bcl 2 cleavage , Bax , Bak , and Bad accumulation , mitochondrial translocation of Bax , abrogation of Mcl 1 , Bcl xL , and XIAP upregulation , and a marked induction of JNK and p 53 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
It is hypothesized that the balance of proapoptotic ( Bad , Bax ) and antiapoptotic ( Bcl 2 , Bcl Xl ) proteins determines apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The viral infection depleted immature B cells ( IgM+SWC3+ ) and favored proapoptotic mRNA expression profiles [ i . e . , suppressed B cell leukemia / lymphoma xl ( Bcl xl ) and stimulated Bcl 2 homologous antagonist / killer ( Bak ) ] in the external inguinal lymph nodes . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Cross linking 4 1BB stimulated expression of the anti apoptotic genes bcl XL and bcl 2 , as well as of cyclins D 2 and E , and inhibited expression of the cyclin dependent kinase ( cdk ) inhibitor p27kip1 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Experiments with BNIP 3 have implicated the transmembrane ( TM ) domain in its proapoptotic function , homodimerization , and interactions with Bcl 2 and Bcl xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Specifically rasagiline activates Bcl 2 , Bcl xl , protein kinase C ( PKC ) and reduces Bax in a variety of cells including PC 12 and neuroblastoma human dopamine derived SH SY5Y cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
This led , in turn , to the activation of the BCL 2 homology 3 domain only proteins BIM and BAD and down regulation of the anti apoptotic multi BCL homology domain protein BCL xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
However , neither JNKI 1 nor JBD did influence IL 1beta induced NO synthesis or iNOS expression or the transcription of the genes encoding mitochondrial manganese superoxide dismutase ( MnSOD ) , catalase ( CAT ) , glutathione peroxidase ( GPx ) , glutathione S transferase rho ( GSTrho ) , heat shock protein ( HSP ) 70 , IL 1beta converting enzyme ( ICE ) , caspase 3 , apoptosis inducing factor ( AIF ) , Bcl 2 or Bcl xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We show that malignant epithelial cells from papillary , follicular , and anaplastic thyroid carcinomas express high levels of Bcl 2 and Bcl xL . ^^^ Exogenous expression of either Bcl 2 or Bcl xL in normal thyrocytes was sufficient to prevent chemotherapeutic drug induced cytotoxicity . ^^^ All of the histological thyroid cancer variants examined produced interleukin 4 ( IL 4 ) and interleukin 10 ( IL 10 ) , which increased Bcl 2 and Bcl xL levels and protected thyroid cells from chemotherapeutic agents . ^^^ Exposure to neutralizing antibodies against IL 4 and IL 10 resulted in down modulation of Bcl 2 and Bcl xL , death of a considerable percentage of thyroid cancer cells , and sensitization of the residual tumor population to cytotoxic drug induced apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In the present study , we found that formation of TR3 / RXRalpha heterodimers in the nucleus and their subsequent translocation into the cytoplasm , in association with regulation of apoptosis related proteins Bcl 2 , Bcl xl and Bax , was critical for apoptosis induction by ATRA in breast cancer cells MCF 7 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
To investigate the mechanisms responsible for survival and apoptosis / anoikis in normal human intestinal epithelial crypt cells , we analyzed the roles of various signaling pathways and cell adhesion on the expression of six Bcl 2 homologs ( Bcl 2 , Bcl XL , Mcl 1 , Bax , Bak , Bad ) in the well established HIEC 6 cell model . ^^^ For example , the inhibition of the PI 3 K / Akt 1 pathway down regulated Bcl XL , Mcl 1 , and Bad , while at the same time up regulating Bax , whereas the inhibition of Fak up regulated both Bax and Bak , down regulated Bad , and did not affect the other Bcl 2 homologs analyzed . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
On the other hand , expression levels of the other anti apoptotic factors , such as FLICE inhibitory protein ( FLIP ) , Bcl 2 and Bcl XL , which are associated with the Fas mediated apoptotic signal pathway , did not change after LY 294002 treatment . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
It has previously been shown that the BH 4 domain of Bcl 2 / Bcl xL is essential for the prevention of apoptotic mitochondrial changes , including the release of cytochrome c and apoptotic cell death . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) promotes mitochondrial dysfunction and apoptosis induced by 7 hydroxystaurosporine and mitogen activated protein kinase kinase inhibitors in human leukemia cells that ectopically express Bcl 2 and Bcl xL . ^^^ PD184352 / UCN 01 induced mitochondrial dysfunction and apoptosis were both substantially attenuated in cells ectopically expressing Bcl 2 , an N terminal phosphorylation loop deleted mutant Bcl 2 , or Bcl xL , but not in cells expressing dominant negative ( DN ) caspase 8 , cytokine response modifier A ( cowpox virus encoded antiapoptotic protein ) , or DN Fas associated death domain . ^^^ Coadministration of tumor necrosis factor ( TNF ) related apoptosis inducing ligand ( TRAIL ) or TNF alpha substantially increased MEK inhibitors ( e . g . , PD 184352 or U 0126 ) / UCN 01 induced mitochondrial dysfunction , activation of procaspase 8 and Bid , and apoptosis in Bcl 2 and Bcl xL overexpressing cells but not in those in which the extrinsic pathway was interrupted . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Although the cell death suppressor bcl 2 family proteins ( bcl 2 and bcl XL ) were recently found to suppress the activation of CPP 32 like proteases , the expression levels of death suppressor bcl 2 family proteins did not change when thiols were added . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Expression of Bcl xL and A 1 , antiapoptotic members of the Bcl 2 family , is enhanced by CD 40 ligation , and is suggested to mediate CD 40 induced B cell survival . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Treatment of PC 12 cell cultures with Abeta ( 25 35 ) did not significantly alter total cellular expression levels of Bax , a proapoptotic Bcl 2 family member , or levels of Bcl XL , an antiapoptotic analogue . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Pro death Bax increased , while anti death Bcl 2 and Bcl XL decreased , and apoptotic TUNEL positive cells were detected in the hippocampus of klotho mutant mice at the age of 7 weeks . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
On the basis that Bax and Bad were augmented in B 1a cells , and Bcl 2 and Bcl xL reduced , we conclude that the disappearance of B 1a cells , but not B 1b , in IL 10 / mice results from their enhanced susceptibility to apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Moreover , it reduced the expression of Bcl 2 and Bcl XL proteins , whereas it had no effect on the level of Bax protein . ^^^ These results clearly indicated that MON induced apoptosis in HL 60 cells , associated with the down regulation of Bcl 2 and Bcl XL and the activation of caspase cascades . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In our initial study , no photochemical damage was observed to Bcl xL , in spite of its similarity in size , sequence , location and function to Bcl 2 . ^^^ All five Bcl xL antibodies recognized bacterially expressed Bcl xL , but not Bcl 2 , whereas an anti Bcl 2 antibody recognized Bcl 2 and not Bcl xL . ^^^ Bcl xL localized to mitochondria was considerably more sensitive to photodamage than was Bcl xL in the cytosol , indicating that as previously found for Bcl 2 , Bcl xL must be membrane localized to be photosensitive . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Manipulation of the Fas death receptor pathway from the level of the receptor ( Nok1 / Nok2 , Fas overexpression , and DN FADD ) to the mitochondria ( Bcl xL and Bcl 2 ) did not modulate ZD 9331 + / IFN gamma induced cytotoxicity in HT 29 , with the exception that Nok1 / Nok2 blocking antibodies partially protected HT 29 from the cytotoxic activity of ZD 9331 alone . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
METHODS : We performed semi quantitative RT PCR to examine the expression level of bak , bax , bcl 2 and bcl xL in 70 % hepatectomized rat livers during the whole regeneration process and compared to that of the sham and normal groups . ^^^ RESULTS : The expression of bak and bax was decreased whereas that of bcl 2 and bcl xL was increased in hepatectomized animals compared to normal liver at most time points . ^^^ CONCLUSION : The expression changes of bak , bax , bcl 2 and bcl xL genes are altered not only due to regeneration , but also due to effects of surgical operations . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Prognostic value of immunohistochemical expression of p 53 , bax , Bcl 2 and Bcl xL in resected non small cell lung cancers . ^^^ METHODS AND RESULTS : We investigated the immunohistochemical expression of p 53 and Bcl 2 gene family members ( bax , Bcl 2 and Bcl xL ) in 94 non small cell lung cancer specimens to establish the role of these genes in lung cancer pathogenesis , and to evaluate their prognostic importance . ^^^ Finally , we found no correlation between frequent detection of aberrant p 53 protein and expression of either Bcl 2 , bax or Bcl xL or with patient survival time . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Immunohistochemical analysis of implanted gliosarcoma cells from rats treated with celecoxib showed lower levels of phospho Akt , phospho EGFR , Bcl 2 , and Bcl XL expression compared with untreated tumor cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In addition , the apoptotic process involves activation of caspase 9 , a decrease of Bcl 2 as well as Bcl XL levels , and an increase of Bax levels . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Western blot and immunofluorescence analysis revealed that the anti apoptotic Bcl 2 and Bcl xL levels were downregulated , together with the pro apoptotic Bax protein . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Therefore , to enhance the immune response to the human papillomavirus type 16 ( HPV 16 ) E 7 antigen , we generated a DNA based Semliki Forest virus vector , pSCA 1 , encoding E 7 fused with BCL xL , an antiapoptotic member of the BCL 2 family . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Despite the fact that Siva 1 does not belong to the BCL 2 family , it specifically interacts with the anti apoptotic protein BCL XL and sensitizes MCF 7 breast cancer cells expressing BCL XL to UV radiation induced apoptosis . ^^^ In this paper we demonstrate that the SAH region in Siva 1 is sufficient to specifically interact with the anti apoptotic members of the BCL 2 family such as BCL XL and BCL 2 but not its apoptotic member BAX . ^^^ The underlying mechanism of action of SAH mediated inhibition of BCL XL ( and / or BCL 2 ) cell survival appears to be due to loss of mitochondrial integrity as reflected in enhanced cytochrome c release leading to the activation of caspase 9 and finally caspase 3 . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Anti apoptotic Bcl 2 and Bcl XL , pro apoptotic Bax , caspase 3 and caspase 9 expression and activation were analysed using Western immunoblots and densitometry . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Weak expression of other bcl 2 family member proteins , bax , bcl 2 and bcl xL , were also found in the immunoblots . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The expression of the cyclin dependent kinase ( CDK ) inhibitor p21WAF1 / CIP1 was markedly reduced , but neither Bcl 2 nor Bcl xL or Bax were modulated by c Src inhibition . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In addition to genetic and epigenetic alterations , such as mutational inactivation and silencing of potential tumor suppressor genes , the antiapoptotic proteins Bcl 2 , Bcl xL , and survivin are overexpressed in many human tumors , and targeted inhibition of their expression has potential to facilitate apoptosis induced by various stimuli . ^^^ The oligonucleotide targeting Bcl 2 and Bcl xL was used in the 2 ' MOE or LNA modified gapmer format , the survivin siRNA was derived from the sequence of an effective first generation antisense oligonucleotide . ^^^ In the tumor cells tested , downregulation of Bcl 2 , Bcl xL or survivin expression facilitated apoptosis via the intrinsic and extrinsic signaling pathway and sensitized tumor cells to various chemotherapeutic agents and to TRAIL . ^^^ All combinations of antisense and chemotherapy as well as of Bcl 2 / Bcl xL antisense and TRAIL resulted in more than additive cytotoxicity . ^^^ Although survivin represents a promising target for antisense therapy owing to its tumor selective expression , its downregulation less effectively enhanced TRAIL induced apoptosis compared to the Bcl 2 / Bcl xL antisense approach . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Western blotting revealed no major change in the expression of the EGFR ligand transforming growth factor alpha of bcl 2 , bcl xL , p 53 , p 27 , MDM 2 , akt , activated phospho akt , or mitogen activated protein kinase . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Within the first category , certain proteins ( e . g . , BCL 2 , BCL xL ) act to preserve mitochondrial integrity by preventing loss of mitochondrial membrane potential and / or release of pro apoptotic proteins such as cytochrome C into the cytosol . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Screening by cDNA microarray showed that PPARgamma ligand treatment was associated with upregulation of bad and p 53 , and downregulation of bcl 2 , bcl xl , and cyclin E 1 in MKN 45 cells , which was confirmed by quantitative real time PCR . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We found that cytosolic localization of endogenous wild type or trans activation deficient p 53 was necessary and sufficient for apoptosis . p 53 directly activated the proapoptotic Bcl 2 protein Bax in the absence of other proteins to permeabilize mitochondria and engage the apoptotic program . p 53 also released both proapoptotic multidomain proteins and BH 3 only proteins [ Proapoptotic Bcl 2 family proteins that share only the third Bcl 2 homology domain ( BH 3 ) ] that were sequestered by Bcl xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In this study , we evaluate a recently discovered anti apoptotic gene , aven , and examine its effectiveness alone and in combination with a member of the Bcl 2 family , bcl xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Expression levels of p 53 , Bcl 2 , Bcl xL , Bad , Bax , survivin , Caspase 3 and poly ( ADP ribose ) polymerase ( PARP ) were evaluated by immunoblot analysis . ^^^ During the induction of apoptosis , expression of Bcl 2 , Bcl xL and survivin was decreased , and that of p 53 , Bad and Bax was increased . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 and Bcl xL antagonize apoptosis by blocking the release of caspase activators such as cytochrome c from mitochondria . ^^^ We demonstrated that FKBP 38 , a member of the immunophilin family , interacts and targets these anti apoptotic proteins Bcl 2 and Bcl xL , thereby assisting them in their pro survival role . ^^^ FKBP 38 is specifically localized on mitochondria , at which FKBP 38 is colocalized with Bcl 2 and Bcl xL . ^^^ Expression of exogenous FKBP 38 promotes mitochondrial targeting of Bcl 2 and Bcl xL , while dominant negative FKBP 38 or siRNA of FKBP 38 disturbs their localization . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Diploid human lung fibroblasts were incubated with 3 9 uM Na2CrO4 , and RNA was isolated at 4 , 8 , and 24 h , as well as 24 h after Cr ( 6 ) exposure was terminated ( recovery ) . mRNA expression was quantitated by RNase protection assay with a 32P labeled multi transcript probe containing gene sequences for the cdk inhibitors , p21waf1 / cip1 , p27kip1 , p16INK4a , p15INK4b ; the pro apoptotic proteins bcl XS and bax ; the anti apoptotic proteins bcl W , bcl XL , and bcl 2 , GADD 45 , and cyclin A . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
This evidence that ER induced apoptosis mediated by the mitochondrial pathway was additionally supported by the finding that levels of Bcl 2 , Bcl xl , and XIAP protein were significantly lower ( P < 0 . 01 ) , and levels of Bax and Apaf 1 were elevated ( P < 0 . 02 ) in ER carcinomas versus those carcinomas from control or ER REP rats . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
An early ( 2 3 days post CCI ) E2F1 and p 53 independent apoptosis appeared in the spinal cord as the pro apoptotic bax gene increased ( 320 + / 19 % ) , followed by an increased expression of the anti apoptotic bcl 2 and bcl xL genes ( 60 + / 11 % and 110 + / 15 % , respectively ) 7 days from CCI . ^^^ Despite the MPEP treatment , which normalised bax / bcl 2 and bcl xL / bcl xS ratios at all times post CCI , mechanical hyperalgesia reappeared by 7 days after CCI . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Resveratrol treatment also up regulated the Bax protein and mRNA expression in a dose dependent manner ; however , Bcl 2 and Bcl xL levels were not significantly affected . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl XL / Bcl 2 associated death promoter ( Bad ) , a proapoptotic member of Bcl 2 family , plays an important role in the intrinsic apoptosis pathway . ^^^ Co immunoprecipitation assay revealed that binding of one of the tumor derived Bad mutants with Bcl 2 and Bcl XL is reduced . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
METHODS : Total 40 nasal polyps biopsies were detected the expression of Bcl 2 , Bax , Bcl xL as well as Fas protein on eosinophils by immunohistochemistry . ^^^ RESULTS : In nasal polyps , the expression of Bcl 2 , Bax , Bcl xL and Fas protein on eosinophils are 5 % ( 2 / 10 ) , 65 % ( 26 / 40 ) , 40 % ( 16 / 40 ) and 90 % ( 36 / 40 ) respectively . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Stat 3 C upregulated expression of FLICE inhibitor protein ( FLIP ) , Bcl xL , and Bcl 2 , and accordingly downregulated activities of FLICE and caspase 3 that were redox independent . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Selective induction of apoptosis by the pyrrolo 1 , 5 benzoxazepine 7 [ [ dimethylcarbamoyl ] oxy ] 6 ( 2 naphthyl ) pyrrolo [ 2 , 1 d ] ( 1 , 5 ) benzoxazepine ( PBOX 6 ) in Leukemia cells occurs via the c Jun NH 2 terminal kinase dependent phosphorylation and inactivation of Bcl 2 and Bcl XL . ^^^ PBOX 6 overcomes Bcl 2 mediated resistance to apoptosis in chronic myelogenous leukemia ( CML ) K 562 cells by the time and dose dependent phosphorylation and inactivation of antiapoptotic Bcl 2 family members Bcl 2 and Bcl XL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
RESULTS : Bcl 2 , Bcl XL , and survivin were found to be significantly upregulated in tumor tissues as compared with the normal tissue . ^^^ Protein expression of Bcl 2 and survivin was significantly associated with the loss of differentiation in tumors and that of Bcl XL with nodal metastasis . ^^^ Telomerase activity in these tumors was found to be correlated with Bcl 2 , Bcl XL , and survivin overexpression and with reduced apoptosis , thereby suggesting that novel strategies can be developed to control cancer cell growth by co targeting telomerase and apoptotic pathways . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
UVA induced expression of the anti apoptotic Bcl 2 family member , Bcl XL , with abrogation of expression by using the p 38 MAPK inhibitor SB 202190 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Percentages of CD8+Annexin V+ ( ANX+ ) and CD8+CD95+ cells , changes in mitochondrial membrane potential and levels of expression of Bcl 2 , Bcl XL , and Bax in CD8+ T lymphocytes were measured by quantitative flow cytometry . ^^^ Up regulated Bax and Bcl XL expression , the elevated Bax / Bcl 2 ratio and its association with ANX binding implicate the mitochondrial pathway in death of CD8+ T cells of patients with SCCHN . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Antisense transfected cells expressed high levels of Bax and Bak , but low levels of Bcl 2 and Bcl XL when treated with CDDP , peplomycin , 5 fluorouracil or gamma rays . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In contrast to reported observations in acute promyelocytic leukemia , myeloma cell apoptosis was not associated with either the downregulation of Bcl 2 protein or with alterations in the expression of other Bcl 2 family members , Bax , Bak , Bag , and Bcl xl . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We examined whether 5F could affect apoptosis in human colon cancer HT 29 cells , and test whether and how the over expression of Bcl 2 and Bcl xL could offset the effect of 5F on cell growth . ^^^ Over expression of Bcl 2 or Bcl xL attenuated the increase of p 38 and iNOS induced by 5F . ^^^ The cells with Bcl 2 or Bcl xL over expression showed an elevation of nuclear factor kappa B ( NF kappa B ) activity , accompanying a significant reduction of 5F induced apoptosis . ^^^ These data strongly indicated that the apoptotic effect of 5F on HT 29 was closely associated with the activity of NF kappa B , which was up regulated by Bcl 2 and Bcl xL . ^^^ The apoptotic effect of 5F could be significantly offset by over expression of either Bcl 2 or Bcl xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Difference in expression of Bcl 2 and Bcl xl genes in cisplatin sensitive and cisplatin resistant human in ovarian cancer cell lines . ^^^ To investigate the expression of Bcl 2 and Bcl xl gene in sensitive ( A 2780 ) and drug resistance ( AD 6 ) human ovarian cancer cell lines and explore the molecular mechanism of multidrug resistance , A 2780 and AD 6 were detected by using DNA gel electrophoresis , flow cytometry and RT PCR . ^^^ Our results showed that ( 1 ) `` DNA ladder ' ' was observed in A 2780 and AD 6 after cisplatin treatment ; ( 2 ) after 3 . 0 , 6 . 0 , 9 . 9 microg / ml of cisplatin treatment , a significant difference was noted in the rate of apoptosis between in A 2780 and AD 6 ( P < 0 . 05 ) ; ( 3 ) Bcl 2 and Bcl xl genes were overexpressed in AD 6 . ^^^ After cisplatin treatment , the expression of Bcl 2 and Bcl xl genes was down regulated in A 2780 and AD 6 . ^^^ It is concluded that cisplatin could induce the apoptosis of ovarian cancer cells , and the over expression of Bcl 2 and Bcl xl genes may contribute to apoptotic inhibition and the development of multidrug resistance of human ovarian cancer . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Possibly as an adaptive response , total protein and mRNA levels of cytochrome c and of the anti apoptotic Bcl 2 family member , Bcl xl , increased . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Moreover , overexpression of EDAG in pro B Ba / F3 cells prolonged survival and increased the expression of c Myc , Bcl 2 and Bcl xL in the absence of interleukin 3 ( IL 3 ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
BCNU down regulates anti apoptotic proteins bcl xL and Bcl 2 in association with cell death in oligodendroglioma derived cells . ^^^ Antiapoptotic proteins , Bcl xL and Bcl 2 , are over expressed in early passage cell lines derived from glioblastomas . ^^^ Down regulation of Bcl xL and Bcl 2 with DNA antisense oligonucleotides promotes cell death in glioblastoma cells . ^^^ Changes of expression of Bcl xL and Bcl 2 after chemotherapy treatment have not been studied in glioma subtypes . ^^^ The current experiments correlate decreased expression of both Bcl xL and Bcl 2 after BCNU chemotherapy and cell death in two oligodendroglioma derived cell lines . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
This effect was found to correlate with the up regulation of Fas / APO 1 , Fas ligand , and Bax , and down regulation of NF kappaB , Bcl 2 , and Bcl XL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In parallel cultures , there was a significant increase in Bad and Bax expression , concomitant with an increase in DNA fragmentation , and a significant decrease in Bcl 2 and Bcl XL expression . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
At the molecular level , IGF IR deficiency in fetal brown adipocytes altered the balance of the expression of several proapoptotic ( Bcl xS and Bim ) and antiapoptotic ( Bcl 2 and Bcl xL ) members of the Bcl 2 family . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Using indirect inmunohistochemical method , the expression of Bcl XL and Bax , anti and proapoptotic proteins of Bcl 2 family , as well as of cytokine IL 1beta were studied to demonstrate the role of these substances in apoptosis regulation of sensory neurons of different subpopulations after the severance of their peripheral processes . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Furthermore , increased expression of activated Ras correlated with elevated levels of Bcl xL expression and a slower migrating , band shifted form of Bcl 2 . ^^^ Increased B cell apoptosis correlated with reduced expression of Bcl xL , suggesting that this Bcl 2 family member may be involved in apoptosis inhibition mediated by LMP2A . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The anti apoptotic effect of Epo correlates with upregulation of bcl 2 and bcl XL , suggesting a mechanism similar to those described in hematopoietic cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
DHA markedly increased the inhibitory effect of 5 FU on the expression of the antiapoptotic proteins BCL 2 and BCL XL , and induced overexpression of c MYC which has recently been shown to drive apoptosis and , when overexpressed , to sensitize cancer cells to the action of proapoptotic agents , including 5 FU . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Biochemical examination of tumors from GQ ODN treated mice demonstrated a significant reduction in Stat 3 activation , levels of the antiapoptotic proteins Bcl 2 and Bcl xL , and an 8 fold increase in the number of apoptotic cells compared with the tumors of placebo treated mice . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Apoptotic responsiveness of PC 3 prostate cancer cells to tumor necrosis factor related apoptosis inducing ligand : evidence for differential effects of Bcl xL and Bcl 2 down regulation . ^^^ In this report , we show that down regulation ( ' knockdown ' ) of Bcl xL , but not Bcl 2 , markedly amplifies TRAIL induced apoptosis in PC 3 prostate carcinoma cells . ^^^ The knockdown was accomplished by second generation chimeric antisense oligonucleotides : Bcl 2 and Bcl xL levels were strongly and reproducibly reduced , as revealed by real time RT PCR and Western blot analyses . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Hypoxia induced renal epithelial cell death through caspase dependent pathway : role of Bcl 2 , Bcl xL and Bax in tubular injury . ^^^ Anti apoptotic factors , Bcl 2 and Bcl xL , were significantly decreased in epithelial cells under a hypoxic condition as assessed by Western blotting ( p < 0 . 01 ) . ^^^ The pro apoptotic mechanisms of hypoxia in epithelial cells largely depend on a significant decrease in Bcl 2 and Bcl xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The expression of important proapoptotic ( Bcl xs , Bax , p 53 , caspase 3 ) and antiapoptotic genes ( Bcl 2 and Bcl xL ) was also altered by tumor cachexia . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In addition , estrogen increases antiapoptotic proteins , Bcl 2 and Bcl xL , which prevents activation of the permeability transition pore protecting against estrogen induced increase in mitochondrial Ca2+ sequestration . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In this investigation , we used human 1321N1 astrocytoma cells expressing a recombinant P2Y2 receptor to assess the role of this receptor in the regulation of anti apoptotic ( bcl 2 and bcl xl ) and pro apoptotic ( bax ) gene expression . ^^^ Acute treatment with the P2Y2 receptor agonist UTP up regulated bcl 2 and bcl xl , and down regulated bax , gene expression . ^^^ Activation of P2Y2 receptors was also coupled to the phosphorylation of cyclic AMP responsive element binding protein that positively regulates bcl 2 and bcl xl gene expression . ^^^ Cyclic AMP responsive element decoy oligonucleotides markedly attenuated the UTP induced increase in bcl 2 and bcl xl mRNA levels . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In the hippocampus , an increase in pro apoptotic Bcl 2 family proteins Bcl XS and Bak was detected , concomitant with proteolysis of Bcl XL and Bcl 2 , following ischemia reperfusion injury . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
IT treatment caused after 2 . 5 hr a significant decrease in the level of the antiapoptotic protein Mcl 1 but not of Bcl 2 and Bcl XL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Such counterselection would have to be compensated for by other antiapoptotic mutations , and indeed , strong upregulation of the antiapoptotic Bcl 2 family member Bcl xL was found in one of the tumors . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In ER stressed cells , but not in normal cells , Bcl xL was co immunoprecipitated with Bim , a pro apoptotic member of the Bcl 2 family , suggesting that Bcl xL sequesters Bim , thereby inhibiting the apoptotic signaling . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
HUVECs in vitro expressed Bcl 2 , Bcl xL , and Bax ; however , expression was not changed by SNAP treatment in the presence or absence of LLL CHO , etoposide , or C 2 ceramide . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Increased apoptosis was a result of enhanced caspase 8 activity , while Bcl 2 and Bcl XL transgene expression had little effect on this phenotype . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Moreover , oridonin increased the ratio of Bax / Bcl 2 protein expression , whereas it had no effect on the expression of Bcl xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Combined treatment with low concentrations of these two agents also acted synergistically to induce apoptosis in HepG 2 cells through induction of Bax and Apaf 1 , reduction of Bcl 2 and Bcl xL , and activation of caspase 3 , 8 , and 9 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Recent studies have found that Bcl xL , as a member of the bcl 2 family of proteins that inhibit apoptosis , is essential in megakaryocytic differentiation . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl xL , an antiapoptotic member of the Bcl 2 family , is expressed in hepatocytes and up modulated during various pathologic conditions . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Furthermore , the balance between pro apoptotic ( i . e . , Bax ) and anti apoptotic ( i . e . , Bcl 2 or Bcl xL ) proteins , which was rather pro apoptotic after IR exposure , became anti apoptotic 24 h later , suggesting a protective effect . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Furthermore , a marked down regulation of the expression of the Bcl 2 , Bcl XL and XIAP , and up regulation of the Bax and Bad proteins were noted . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Whereas TSA treatment increased the expression level of Bad , it decreased the level of Bcl 2 , Bcl xL , and 10 linked inhibitor of apoptosis protein . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Ectopic expression of Bcl 2 or Bcl xL but not dominant negative caspase 8 blocked UCN 01 / L744832 mediated mitochondrial dysfunction and apoptosis but did not prevent activation of p 34 ( cdc 2 ) and JNK or inactivation of MEK / ERK and Akt . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Caseamembrin C induced down regulation of Bcl 2 and Bcl xL expression , while up regulation of proapoptotic protein Mcl 1S ( short chain ) , suggesting that these Bcl 2 family member proteins may play a role on arbitrating the apoptotic cell death . ^^^ Taken together , it is suggested that caseamembrin C induced apoptosis is predominantly through the activation of intrinsic apoptosis pathways by causing the down regulation of Bcl 2 and Bcl xL expression , up regulation of Mcl 1S protein and activation of caspase 9 and caspase 3 . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
OBJECTIVE : To clarify the in vitro effects of inhibin A ( 1 ) on apoptotic cell death and its mechanisms in ovarian granulosa cells the immunoexpression patterns of the apoptosis markers caspase 3 and pro and anti apoptotic proteins ( Bcl 2 , Bcl xl , Bak ) were evaluated in ovarian granulosa cells collected from women with different hormonal status . ^^^ The expression of caspase 3 , Bak , Bcl 2 , Bcl xl was investigated immunohistochemically . ^^^ Inhibin A exposition enhanced the immunoexpression of prooncogenes ( Bcl 2 , Bcl xl ) and reduced the expression of caspase 3 and pro apoptotic protein Bak in ovarian granulosa cells from the three experimental groups . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The expression of Bcl 2 , Bcl xl , Bak and Bax proteins in axons of the optic nerve in closed angle glaucoma ] . ^^^ PURPOSE : The aim of our study was the evaluation of Bcl 2 , Bcl xl , Bak and Bax immunoexpression in axons of the optic nerve with absolute glaucoma . ^^^ The samples were immuno stained with antibodies for Bcl 2 , Bak , Bax and Bcl xl protein . ^^^ RESULTS : In our study proapoptotic Bak and Bax protein expression was stronger than antiapoptotic Bcl 2 , Bcl xl protein expression ; Bak / Bcl 2 ( p = 0 . 008 ) , Bax / Bcl 2 ( p = 0 . 0007 ) , Bak / Bcl xl ( p = 0 . 0356 ) , Bax / Bcl xl ( p = 0 . 0077 ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Western blotting analyses revealed that IFN gamma dramatically increased the protein levels of interferon regulatory factor ( IRF ) 1 , but not TRAIL receptors ( DR 4 and DR 5 ) and pro apoptotic ( FADD and Bax ) and anti apoptotic factors ( Bcl 2 , Bcl XL , cIAP 1 , cIAP 2 and XIAP ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
While SCF up regulated the expression of the anti apoptotic proteins Bcl 2 and Bcl xL , it did the opposite to the pro apoptotic factor Bax . ^^^ The PI3K inhibitor reversed the regulation of SCF on Bcl xL and Bax but not on Bcl 2 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The combination treatment activated caspase 3 and cleaved PARP , but it did not induce any notable change in the expression of Bcl XL , Bcl 2 and Bax compared with each single treatment . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The growth inhibitory effects of resveratrol are mediated through cell cycle arrest ; upregulation of p21Cip1 / WAF1 , p 53 and Bax ; down regulation of survivin , cyclin D 1 , cyclin E , Bcl 2 , Bcl xL and clAPs ; and activation of caspases . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
MATERIALS AND METHODS : The combined immunohistochemical expression levels of the proteins bax , bak , bad , bid , bcl 2 and bcl xl were evaluated by cluster and discriminant analysis . ^^^ RESULTS : Cluster analysis produced : a ) a low expression ( 69 / 79 cases ) and a high expression pro apoptotic cluster ( 10 / 79 cases ) for the combined expression levels of the pro apoptotic proteins bax , bak , bad and bid and b ) a low expression ( 37 / 76 cases ) and a high expression antiapoptotic cluster ( 39 / 76 cases ) for the combined expression levels of anti apoptotic proteins bcl 2 and bcl xl . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Overexpression of Bcl 2 , Bcl xL , or mutant DN Fas associated death domain protected HT 29 cells from TRAIL induced apoptosis in the presence of the CKI inhibitor . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Furthermore , the ability of yeast Fis 1 to inhibit mitochondrial fission and cell death can be functionally replaced by human Bcl 2 and Bcl xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In addition , Bcl 2 , Bcl xL , Bax , and Bak localized in the mitochondria were detected . ^^^ In these rats , mitochondrial wt p 53 was significantly inhibited through decreased mitochondrial localization of wt p 53 and increased cytosolic p 53 , resulting in the upregulation of Bcl 2 and Bcl xL and the downregulation of Bak in the mitochondria . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
However , the expression of anti apoptotic mediators such as bcl 2 and bcl xL did not show any significant change . ^^^ These results suggest that cytokine and STZ mediated apoptotic effects on islet cells might be mediated by a glucose induced hyperfunctional status and associated with an increase in Fas ( Apo 1 , CD 95 ) expression and no changes in the expression of the anti apoptotic proteins bcl xL and bcl 2 . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In addition , SM caused release of cytochrome c , downregulation of anti apoptotic Bcl 2 and Bcl xL , increase of caspase 3 activity , and DNA fragmentation . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Antiapoptotic Bcl 2 family proteins Bcl xL and Mcl 1 also increase mitochondrial H ( 2 ) O ( 2 ) release when overexpressed . ^^^ Our results indicate that chronic and mild elevations in H ( 2 ) O ( 2 ) release from Bcl 2 , Bcl xL , and Mcl 1 overexpressing mitochondria lead to enhanced cellular antioxidant defense and protection against death caused by acute oxidative stress . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
About 35 40 % of the cells became apoptotic when exposed to PS 341 ( 10 ( 7 ) M , 24 48 h ) as shown by Annexin 5 analysis ; in concert with these findings , immunobloting showed a C terminal 85 kDa apoptotic fragment of poly ADP ribose polymerase ( PARP ) , and a decreased level of Bcl 2 and Bcl xl . ^^^ PS 341 downregulated the expression of Bcl 2 and Bcl xl in protein levels at an early time of treatment . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Characterization of vinblastine induced Bcl xL and Bcl 2 phosphorylation : evidence for a novel protein kinase and a coordinated phosphorylation / dephosphorylation cycle associated with apoptosis induction . ^^^ Bcl xL and Bcl 2 are phosphorylated in response to microtubule inhibitors , but the kinase ( s ) responsible and the functional significance have remained unclear . ^^^ In this study , we investigated the characteristics of Bcl xL and Bcl 2 phosphorylation in KB 3 carcinoma cells treated with vinblastine . ^^^ In both asynchronous and synchronous cell cultures , Bcl xL and Bcl 2 underwent a well defined and coordinated cycle of phosphorylation and dephosphorylation , with a lengthy period of phosphorylation preceding apoptosis induction , and with dephosphorylation closely correlated with initiation of apoptosis . ^^^ Internally , validated inhibitors of JNK , ERK , p 38 ( MAPK ) , or CDK 1 failed to inhibit vinblastine induced phosphorylation of Bcl xL or Bcl 2 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Western blot analyses were performed on cultured seminiferous tubule segments for Bcl 2 family proteins ( Bax , Bad , Bcl w , Bcl xL ) and fas ligand . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
No effect of the two cytokines on major members of apoptosis regulating systems ( CD 95 , CD95L , bcl 2 , bax , bcl xL , p 53 , p21WAF1 , p 27 , NFkappaB ) could be observed . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Overexpression of the antiapoptotic proteins Bcl 2 and Bcl XL is commonly observed in human malignancies and contributes to chemotherapy and radiation resistance . ^^^ Bcl 2 and Bcl XL inhibit apoptosis by binding to proapoptotic proteins such as Bax , thereby preventing chemotherapy induced or radiation induced release of cytochrome c from mitochondria and subsequent activation of the caspase protease cascade . ^^^ Efforts to inhibit Bcl 2 or Bcl XL function in tumor cells have focused on developing agents to inhibit the interactions of these proteins with proapoptotic proteins . ^^^ Peptides derived from the BH 3 domains of proapoptotic proteins have been shown to disrupt the interactions of Bcl 2 and Bcl XL with key binding partners in cell free reactions and to promote cellular apoptosis . ^^^ Peptides were quantitatively examined for their ability to inhibit Bax / Bcl 2 and Bax / Bcl XL heterodimerization in vitro and to promote cytochrome c release from mitochondria isolated from Jurkat , HL 60 , U 937 , and PC 3 cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
BCL 2 and BCL XL are antiapoptotic proteins , of which overexpression has been reported to confer resistance to anticancer agents . ^^^ High levels of BCL 2 and BCL XL are frequently expressed in SCLC tumors . ^^^ FR 901228 down regulated the expression of bcl 2 and bcl xL mRNA through de novo protein synthesis and suppressed the expression of BCL 2 and BCL XL proteins . ^^^ Considering the possible contributions of BCL 2 and BCL XL to multidrug resistance , FR 901228 is a promising agent in the treatment of refractory as well as primary SCLC tumors . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Apoptosis induced by BaP 1 on endothelial cells was independent of two Bcl 2 family members ( anti apototic Bcl xL and pro apoptotic Bax ) , that did not show any changes in their expression during a 24 h treatment period . ^^^ In conclusion , treatment of human endothelial cells with BaP 1 induces apoptosis / anoikis , independently of Bcl 2 family members Bax and Bcl xL and associated with caspase 8 activation and cFLIP ( L ) up regulation . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
HMBA , used at cytostatic concentrations , reduced the ratio be tween antiapoptotic ( Bcl 2 , Bcl XL ) and proapoptotic ( Bax ) members of the Bcl 2 family of proteins , thus lowering the threshold for MM cell death commitment . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Using lysate RNase protection assays , mRNA expression of the anti cell death genes Bcl 2 and Bcl xL , and the pro cell death gene Bax , was evaluated following experimental brain injuries in adult male Sprague Dawley rats . ^^^ Anti cell death bcl 2 and bcl xL mRNAs were attenuated early and tended to remain depressed for at least 3 days after injury in the cortex and hippocampus ipsilateral to injury . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In these cells , GMCSF activated STAT 5 , but not STAT 3 , and induced an increase in the mRNA of the antiapoptotic Bcl 2 member , Bcl xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Although mutations in Mcl 1 had little impact on binding , a single mutation in the BH 3 only ligand Bad enabled it to bind both Mcl 1 and A 1 while retaining its binding to Bcl 2 , Bcl xL , and Bcl w . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The expression of Bcl 2 family members , Bcl xL , Bcl 2 , Mcl 1 and Bax was investigated in delayed apoptosis of canine neutrophils induced by lipopolysaccharide ( LPS ) . ^^^ The levels of Bcl xL , Bcl 2 , Mcl 1 and Bax transcripts at 9 h incubation in neutrophils stimulated by LPS ( 100 ng / ml ) were increased by about 80 . 4 , 1 . 9 , 1 . 4 and 5 . 3 folds , in comparison to those in non stimulated neutrophils , respectively . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Trastuzumab down regulates Bcl 2 expression and potentiates apoptosis induction by Bcl 2 / Bcl XL bispecific antisense oligonucleotides in HER 2 gene amplified breast cancer cells . ^^^ EXPERIMENTAL DESIGN : Bcl 2 and Bcl XL expression and apoptosis induction were analyzed in HER 2 gene amplified ( BT 474 ) and nonamplified ( ZR 75 1 ) breast cancer cell lines exposed to trastuzumab , alone or in combination with either Bcl 2 / Bcl XL bispecific antisense oligonucleotides ( AS 4625 ) or the small molecule Bcl 2 antagonist HA 14 1 . ^^^ RESULTS : In addition to HER 2 and epidermal growth factor receptor , trastuzumab down regulated Bcl 2 , but not Bcl XL , protein , and mRNA expression in BT 474 cells . ^^^ AS 4625 treatment of BT 474 cells decreased both Bcl 2 and Bcl XL expression , resulting in a 21 + / 7 % net apoptosis induction ; the combination of AS 4625 followed by trastuzumab resulted in a significantly stronger induction of apoptosis ( 37 + / 6 % , P < 0 . 01 ) that was not observed with the reverse treatment sequence ( trastuzumab followed by AS 4625 ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Thus , a nonpeptidic , cell permeable small molecule that mimics the BH 3 domain of proapoptotic proteins may inhibit Bcl xL function and have therapeutic potential for HNSCC by overcoming drug resistance . ( ) Gossypol , the levorotatory isomer of a natural product isolated from cottonseeds and roots , was recently discovered to bind to the BH 3 binding groove of Bcl xL and Bcl 2 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Induction of apoptosis was confirmed by the appearance of sub G 1 populations , and apoptosis cascade involved upregulation of the apoptosis enhancing proteins ( Bak and Bcl xS ) and downregulation of the apoptosis suppressing proteins ( Bcl xL and Bcl 2 ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
RESULTS : ErbB 2 inhibition was associated with a dramatic increase in expression of the pro apoptotic Bcl 2 family protein Bcl xS and decreased levels of anti apoptotic Bcl xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Western blot analysis showed that combinations of ICI 182780 and BE 3 3 3 caused down regulation of the anti apoptotic Bcl 2 and Bcl XL proteins and increased the level of the pro apoptotic Bax protein . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
All patients were treated by BOAI , and expression of cancer cell apoptosis was examined by the TUNEL method , expression of bax , bcl 2 and bcl xL proteins were examined by immunohistochemistry , and expression of bax , bcl 2 and bcl xL mRNA was examined by quantitative RT PCR before and 3 days after BOAI . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Antisense oligodeoxynucleotides , and more recently small molecule ligands for BCL 2 and BCL XL , are directly cytotoxic or synergistic with standard cytotoxic agents , and in some cases , may demonstrate selectivity for tumor cells . ^^^ Despite these problems , a substantial number of small molecules that bind to BCL 2 or BCL XL are now available for pre clinical testing ; in turn , basic studies with these reagents should yield new insights about optimal strategies to disrupt BCL 2 survival functions . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Immunohistochemistry was performed on paraffin wax sections using antibodies against cyclin D 1 , Bcl 2 , Bcl xL , p 27 , p 21 , p 53 , MIB 1 , CD 20 , and CD 56 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Hence , TFEC induced necrotic cell death in the TAMH cell line is mediated by BAX and antagonized by the anti apoptotic BCL 2 family member , BCL xL . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Although most studies focus on phosphorylation of pro and antiapoptotic proteins ( BAD , Bax , Bcl 2 , Bcl xL ) , kinase mediated regulation of complex 1 activity , anion and cation channels , metabolic enzymes , and Mn SOD mRNA has also been reported . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Proapoptotic Bcl 2 family member Bim is involved in the control of mast cell survival and is induced together with Bcl XL upon IgE receptor activation . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The mechanism of neuroprotective activity has been attributed to the ability of propargylamines inducing the antiapoptotic family proteins Bcl 2 and Bcl xl , while decreasing Bad and Bax and preventing opening of mitochondrial permeability transition pore . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Expression levels of inhibitory apoptosis proteins ( IAPs ) , including cellular IAP 1 ( cIAP 1 ) , cIAP 2 , 10 linked IAP ( XIAP ) , and survivin , and Bcl 2 family members such as Bcl xl and Bad , were determined by Western blot analysis and / or RT PCR , real time PCR . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
A functionally improved locked nucleic acid antisense oligonucleotide inhibits Bcl 2 and Bcl xL expression and facilitates tumor cell apoptosis . ^^^ We previously reported the Bcl 2 / Bcl xL bispecific activity of the 2 ' O ( 2 methoxy ) ethyl ( 2 ' MOE ) modified gapmer antisense oligonucleotide 4625 . ^^^ This oligonucleotide has 100 % complementarity to Bcl 2 and three mismatches to Bcl xL . ^^^ We describe for the first time the functional comparison of isosequential Bcl 2 / Bcl xL bispecific 2 ' MOE and LNA modified antisense oligonucleotides and report that the LNA analog more effectively downregulated the two apoptosis inhibitors overexpressed in human tumors . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
This review notably summarizes the present knowledge of the ( de ) regulation of the effects of androgens , p 53 , Bcl 2 , Bcl xL , Bax , Akt , PTEN , Par 4 , clusterine , caspases and NF kappaB in prostate adenocarcinoma cell lines and provides an appraisal of their therapeutic potential . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In the SCP group , p 53 protein expression was observed in 30 cases ( 66 . 6 % ) , Ki 67 in 14 ( 31 . 1 % ) , PCNA in 44 ( 97 . 8 % ) , Bcl 2 in 24 ( 53 . 3 % ) , Bak in 28 ( 62 . 2 % ) , Bax in 31 ( 68 . 9 % ) , and Bcl xl in 11 ( 100 % ) . ^^^ In the SCC group , p 53 protein expression was evaluated in 8 cases ( 72 . 8 % ) , Ki 67 in 2 ( 18 . 2 % ) , PCNA in 8 ( 72 . 7 % ) , Bcl 2 in 5 ( 45 . 4 % ) , Bax and Bak both in 10 ( 90 . 9 % ) , and Bcl xl in 100 % . ^^^ In the BCC group , p 53 protein expression was estimated in 23 cases ( 85 . 1 % ) , Ki 67 in 13 ( 48 . 1 % ) , PCNA in 26 ( 96 . 2 % ) , Bcl 2 in 13 ( 48 . 1 % ) , Bak in 21 ( 77 . 8 % ) , Bax in 22 ( 81 . 5 % ) , and Bcl xl in 23 ( 85 . 2 % ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl xl , in contrast to bcl 2 and c FLIP , is strongly upregulated after viral infection and represents an essential NFkappaB dependent survival factor against TRAIL mediated apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We identified early proapoptotic transcriptional changes , including upregulation of proapoptotic Bax and downregulation of antiapoptotic Bcl xL , Bcl 2 , and Bcl w , using Affymetrix DNA microarrays . ^^^ Because Bcl xL is the most robustly expressed antiapoptotic Bcl 2 molecule in adult central nervous system , we decided to characterize better the effect of SCI on Bcl xL expression . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The expression of bcl xL mRNA was significantly decreased in the OP treated groups , whereas the expressions of bcl 2 and bax mRNA were not significantly changed . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
All three agents induce a decrease of intracellular levels of Bcl 2 and Bcl xL , with an increased level of Smac , indicating that they are capable of promoting a downregulation of anti apoptotic factors and an accumulation of pro apoptotic mediators . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
High glucose inhibits apoptosis induced by serum deprivation in vascular smooth muscle cells via upregulation of Bcl 2 and Bcl xl . ^^^ Furthermore , exposure of VSMCs to high glucose markedly increased the abundance of Bcl 2 and Bcl xl mRNAs compared with treatment with normal glucose , while expression of bax and IAP 1 mRNA remained unchanged . ^^^ Our results suggest that high glucose suppresses serum withdrawal induced apoptosis in VSMCs by upregulating expression of Bcl 2 and Bcl xl , suggesting that enhanced expression of antiapoptotic proteins may play an important role in the development of macrovascular complications in diabetes . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
METHODS : We examined the expression pattern of bax , bcl 2 , bcl xL , mtd , and bcl w both at messenger RNA ( mRNA ) and protein level in the brain tissues during the formation of epilepsy with kindling model in adult rats , which has been the most acceptable form of experimental model of human epilepsy . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
This study focused on the immunohistochemical detection of the expression levels of Bcl 2 family regulators ( anti apoptotic Bcl 2 and Bcl XL , pro apoptotic Bcl Xs and Bax ) , p 53 , and PCNA as a marker of proliferation , together with the evaluation of the level of apoptosis in human embryos ( anlage of limbs , axial skeleton , metanephros , and intestine ) . ^^^ This study provided circumstantial evidence of the exclusive role of Bcl 2 and Bcl XL proteins in the inhibition of apoptosis only rarely were the Bcl 2 / Bcl XL positive cells stained by TUNEL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
B [ a ] P , B [ a ] P 7 , 8 DHD and BPDE 1 induced an accumulation and phosphorylation of p 53 , while the Bcl 2 proteins Bcl xl , Bad and Bid were down regulated . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
High titered anti HLA Ab stimulate cell proliferation whereas low titered Ab activate the PI3K / Akt pathway and promote expression of cell survival proteins including Bcl 2 and Bcl xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Combined treatment with TNP 470 and docetaxel synergistically inhibited PC 3 cell growth in vitro through the enhanced induction of apoptotic cell death compared with treatment with either agent alone , a result explained , at least in part , by the down regulation as well as phosphorylation of potential anti apoptotic genes , Bcl 2 and Bcl XL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The expression of Bcl XL , Bcl 2 , and XIAP significantly decreased , and activation of JNK was prolonged for up to 6 h in infected cells treated with TNF alpha . ^^^ The expression of Bcl XL , Bcl 2 and XIAP and activation of JNK were affected by ad IkappaB SR transduction , implying a role in the NF kappaB regulated cell survival signaling in human chondrocytes . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NF kappaB regulated gene products such as Cyclin D 1 , c Myc , COX 2 , MMP 9 , ICAM 1 , MDR 1 , Survivin , XIAP , IAP 1 , IAP 2 , FLIP , Bcl 2 , Bcl xL , and Bfl 1 / A1 were all down regulated by evodiamine . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Phospho ser 15 p 53 translocates into mitochondria and interacts with Bcl 2 and Bcl xL in eugenol induced apoptosis . ^^^ Phospho ser 15 p 53 physically interacted with Bcl 2 and Bcl xL in mitochondria and its translocation into mitochondria preceded cytochrome c release and mitochondrial membrane potential ( MMP ) reduction . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The cleavage of the proapoptotic Bcl 2 proteins , such as Bad and Bax to produce their truncated forms , and the cleavage of the antiapoptotic Bcl 2 proteins , such as Bcl 2 and Bcl XL , into their potent pro apoptotic fragments were detected in our study . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The majority of human prostate cancers overexpress the important antiapoptotic proteins Bcl 2 and / or Bcl xL , which render tumors resistant to radiation therapy . ( ) Gossypol , a natural polyphenol product from cottonseed , has recently been identified as a potent small molecule inhibitor of both Bcl 2 and Bcl xL . ^^^ Our data show that ( ) gossypol potently enhanced radiation induced apoptosis and growth inhibition of human prostate cancer PC 3 cells , which have a high level of Bcl 2 / Bcl xL proteins . ^^^ Our results show that the natural polyphenol inhibitor of Bcl 2 / Bcl xL , ( ) gossypol , can radiosensitize prostate cancer in vitro and in vivo without augmenting toxicity . ( ) Gossypol may improve the outcome of current prostate cancer radiotherapy and represents a promising novel anticancer regime for molecular targeted therapy of hormone refractory prostate cancer with Bcl 2 / Bcl xL overexpression . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The constitutive expression of antiapoptotic proteins Bcl 2 and Bcl xl were decreased after silymarin treatment , whereas the expression of the proapoptotic protein Bax was increased . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Separate groups underwent an analysis examining tissue at multiple time points after I / R injury including histopathology ; myeloperoxidase staining ; immunostaining for CD 3 and ED 2 ; polymerase chain reaction analysis of interleukin ( IL ) 8 / cytokine inducible neutrophil chemoattractant , IL1beta , IL 6 , interferon gamma , IL 2 , IL 4 , and IL 10 ; and western blots for hemoxygenase 1 , BCL 2 , and BCL xl . ^^^ Last , treatment resulted in increased production of hemoxygenase , BCL 2 , and BCL xl . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Similarly , the deficiency influenced oppositely transcriptions of apoptosis related genes , i . e . decreased expression of bcl xL and increased expression of bcl 2 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The antiapoptotic proteins , Bcl 2 and Bcl xl , were downregulated by GSP , whereas the expression of the pro apoptotic protein , Bax , and the levels of cytochrome c release , Apaf 1 , caspase 9 , and cleaved caspase 3 ( p 19 and p 17 ) were markedly increased in JB 6 C141 cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Thiazolidenediones mediate apoptosis in prostate cancer cells in part through inhibition of Bcl xL / Bcl 2 functions independently of PPARgamma . ^^^ Evidence indicates that the apoptotic effect of troglitazone , ciglitazone , and their PPARgamma inactive analogues 5 [ 4 ( 6 hydroxy 2 , 5 , 7 , 8 tetramethyl chroman 2 ylmethoxy ) benzylidene ] 2 , 4 thiazolidine dione ( Delta 2 TG ) and 5 [ 4 ( 1 methyl cyclohexylmethoxy ) benzylidene ] thiazolidine 2 , 4 dione , respectively , is in part attributable to their ability to inhibit the anti apoptotic functions of Bcl xL and Bcl 2 . ^^^ Treatment of PC 3 cells with troglitazone or Delta 2 TG led to reduced association of Bcl 2 and Bcl xL with Bak , leading to caspase dependent apoptosis . ^^^ Considering the pivotal role of Bcl xL / Bcl 2 in regulating mitochondrial integrity , this new mode of mechanism provides a framework to account for the PPARgamma independent action of thiazolidenediones in inducing apoptosis in cancer cells . ^^^ Moreover , dissociation of these two pharmacologic activities provides a molecular basis to develop novel Bcl xL / Bcl 2 inhibitors , of which the proof of principle is illustrated by a Delta 2 TG analogue with potent in vivo antitumor activities . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The plasmid , pBCL , directs the expression of a target polypeptide fused to the C terminus of a mutant form of the anti apoptotic Bcl 2 family protein , Bcl XL , where the hydrophobic C terminus has been deleted , and Met residues have been mutated to Leu to facilitate CNBr cleavage after a single Met inserted at the beginning of the target sequence . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In the 6th and 8th week of intrauterine development we observed isolated TUNEL positive epithelial cells only and this was accompanied by the disperse presence of PCNA as well as by all the studied proteins : Bcl 2 , Bax , Bcl XL , c myc , N myc , p 53 , p 63 and p 73 . ^^^ In the presence of Bcl 2 , Bax , Bcl XL , p 63 and p 73 we did not find any dramatic changes . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Interestingly , apoptotic +SA cells showed a paradoxical decrease in mitochondrial levels of pro apoptotic proteins Bid , Bax , and Bad , and a corresponding increase in mitochondrial levels of anti apoptotic proteins , Bcl 2 and Bcl xL , suggesting that mitochondrial membrane stability and integrity might actually be enhanced for a limited period of time following acute tocotrienol exposure . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Ectopic expression of Bcl xL , but not Bcl 2 , in PC 3 cells offered significant protection against the cell death caused by SFN . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Indeed , bortezomib induced increases of Bik and / or Bim in multiple cell lines but not notably of two other BH 3 only proteins ( Puma and Bid ) nor other family members ( Bax , Bak , Bcl 2 , and Bcl xL ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Coadministration of UCN 01 and rapamycin reduced the expression levels of the antiapoptotic members of the Bcl 2 family Mcl 1 and Bcl xL and diminished the expression of cyclin D 1 and p 34 ( cdc 2 ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl XL and Bcl 2 are predominantly overexpressed in pancreatic cancer cell lines , respectively . ^^^ Geldanamyin and PS 341 synergistically block NFkappaB activation , suppress Akt / PKB pathway , and down regulate Bcl XL , Bcl 2 , cIAP 1 , and cyclin D 1 expression . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
MX 3350 1 decreased the levels of antiapoptotic Bcl 2 and Bcl XL , increased proapoptotic Bax , induced mitochondrial membrane permeabilization ( MMP ) , and cytochrome c release from mitochondria to cytosol . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In general , WW 85 had no direct action on expression of the proapoptotic gene , Fas ligand ; however , WW 85 given alone or with cyclosporine enhanced expression of antiapoptotic genes Bcl 2 and Bcl xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In conjugation with this event , the reduction of anti apoptotic molecules ( Bcl 2 and Bcl xL ) was caused by the combination of Cx 32 expression and PP 1 treatment in Caki 2 cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
G CSF treated patients showed higher apoptosis frequency , lower expression of bcl 2 and bcl xL , but higher expression of bfl 1 / A1 and mcl 1 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
EXPERIMENTAL DESIGN : We studied whether Bcl 2 , Bcl xL , Mcl 1 , Bax as well as the Bcl 2 / Bax ratio and a combination of all ( antiapoptosis index , AAI ) are related to the frequency of malignant cells surviving the chemotherapy ( i . e . , minimal residual disease , MRD ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
These alterations result in mild uncoupling of mitochondrial state 4 respiration , associated with an inhibition the adenosine diphosphate ( ADP ) stimulated respiration and phosphorylation rate . tBid disruption of mitochondrial homeostasis was inhibited in mitochondria overexpressing Bcl 2 and Bcl XL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Apoptin induced apoptosis does not depend on functional p 53 , and ca n ' t be inhibited by overexpression of Bcl 2 and Bcl xL , but caspase 3 activation is necessary for Apoptin induced rapid apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
To characterize the mechanisms of apoptosis induction by proteasome inhibitors , we examined levels of Bcl 2 protein family members ( Bik / NBK , Bax , Bak , Bcl 2 , and Bcl XL ) , release of cytochrome c , and activation of caspase 9 and 3 in human colon cancer cell lines DLD 1 , LOVO , SW 620 , and HCT 116 ; human lung cancer cell line H 1299 ; and human ovarian cancer cell line SKOV 3 after they were treated with bortezomib . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
On the other hand , intracellular levels of the anti apoptotic proteins , such as Bcl 2 and Bcl xL , and the pro apoptotic protein Bax , were assessed during viral infection . ^^^ These analyses showed that as viral infection proceeded , the cellular level of Bcl xL decreased , while the levels of Bax and Bcl 2 remained unaffected . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Deregulation of the apoptotic machinery plays a major role in cell death , cellular transformation and cancer . p 53 , Bcl 2 , Bcl XL , Bax and Mdm 2 mRNA expression patterns were evaluated in tissue samples with cervical intraepithelial neoplasia ( CIN ) and cervical cancer compared to those of normal cervical tissues , and correlated with the underlying cervical lesions . ^^^ Mdm 2 transcriptional levels correlated significantly with those of Bax , Bcl XL and Bcl 2 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
DNA fragmentation was accompanied by the following phenomena : elevation in the level of hemeoxygenase 1 protein and thioredoxin reductase mRNA ; repression of Mn superoxide dismutase and catalase mRNAs ; release of cytochrome c from mitochondria into the cytosol ; activation of caspases 8 , 9 and 3 ; decrease in the level of Bcl 2 , Bcl XL and Bid protein ; increase in the level of Bad protein . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Increased ARTS in turn leads to a decrease of Bcl 2 and Bcl xL protein levels , cytochrome c release from mitochondria and apoptosis . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Upregulated were Bcl 2 , Bcl xl , Bfl 1 , heat shock protein 27 , and 10 linked inhibitor of apoptosis protein , all of which function to inhibit apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
OBJECTIVES : The present study was designed to analyze the expression of the major antiapoptotic molecules Bcl 2 , Bcl XL and the proapoptotic Bax in pancreatic ductal carcinoma and their correlation to the extent of apoptosis . ^^^ The levels of Bcl 2 , Bcl XL , and Bax mRNA expression were analyzed by semiquantitative reverse transcriptase polymerase chain reaction ( RT PCR ) . ^^^ Semiquantitative RT PCR revealed variable mRNA expression , with the Bcl 2 / Bax ratio ranging from 0 . 2 to 1 . 5 and the Bcl XL / Bax ratio ranging from 0 . 3 to 1 . 8 . ^^^ Immunohistochemical analysis showed positive Bcl 2 , Bax , Bcl XL expression in 20 % , 72 % , and 92 % of cancer samples ; however , their levels were variable . ^^^ However , as compared with the normal pancreas , Bcl 2 , Bcl XL , Bax were overexpressed in most of the pancreatic cancer samples ( Mann Whitney U test , P < 0 . 01 ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 and Bcl xl were also induced as an apparent protective response . ^^^ A 1 was induced in hyperoxia , and in A 1 null mice , the toxic effects of hyperoxia were exaggerated , Bcl 2 and Bcl xl were not induced , and premature death was seen . ^^^ In contrast , IL 11 stimulated A 1 , diminished the toxic effects of hyperoxia , stimulated Bcl 2 and Bcl xl , and enhanced murine survival in 100 % O ( 2 ) . ^^^ In A 1 null mice , IL 11 induced protection , survival advantage , and Bcl 2 and Bcl xl induction were significantly decreased . ^^^ A 1 is an important regulator of oxidant induced lung injury , apoptosis , necrosis , and Bcl 2 and Bcl xl gene expression and a critical mediator of IL 11 and VEGF induced cytoprotection . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Treatment of U 937 cells with MNNG resulted in the inhibition of viability and the induction of apoptosis in a concentration dependent manner , which was associated with a dose dependent upregulation in pro apoptotic Bax protein , downregulation of anti apoptotic Bcl 2 and Bcl xL proteins , and proteolytic activation of caspase 3 protease . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The present study investigates the expression of apoptotic proteins Bax , Bad , Bcl 2 , and Bcl xl following hypoxia in the cerebral cortex of the guinea pig fetus as a function of gestational age . ^^^ Hypoxia resulted in increased expression of the proapoptotic proteins Bax and Bad by 20 % and 30 % in the preterm as compared to 24 % and 38 % at term , without altering the expression of anti apoptotic proteins Bcl 2 and Bcl xl . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
TCTP interacted in vivo and in vitro with Bcl xL , and their sites have been mapped to an N terminal region of TCTP and the Bcl 2 homology domain 3 of Bcl xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In order to understand the molecular alterations leading to heterogeneous cisplatin sensitivity and apoptosis inducibility in NSCLC cells , we analyzed various apoptotic pathways , including the activation of caspase 8 , 9 and 3 , the release of cytochrome c from mitochondria and the expression levels of pro and anti apoptotic proteins such as Bax , Bad , Bcl 2 , Bcl xL , Fas and p 53 using heterogeneously apoptosis sensitive cells ( Ma 10 , Ma 31 and Ma 46 ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Inhibition of core protein expression also altered the expression level of Bcl 2 family proteins , displaying an increase of the proapoptotic Bax and a decrease in the level of the anti apoptotic Bcl xL proteins . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Effect of antineoplastic drugs on the expression of Bcl 2 and Bcl xL genes in the feline T cell leukemia cell line . ^^^ Therefore , we have evaluated the expression of Bcl 2 and Bcl xL in FT 1 upon in vitro treatment with these drugs . ^^^ In the present study , full length of feline Bcl xL gene was sequenced , and the expressions of Bcl 2 and Bcl xL mRNAs in feline lymphoma cell line ( FT 1 ) cultured with doxorubicin , prednisolone or vincristine were investigated . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The objective of this study was to compare the expression levels of both proapoptotic and antiapoptotic proteins p 53 , p 73 , Bcl 2 , Bcl XL and survivin in the ascitic cells and tumor samples of patients undergoing treatment with two different regimens . ^^^ CONCLUSIONS : The above findings indicate that chemotherapy in ovarian carcinoma leads to an increase in apoptosis by a p 53 independent pathway , which involves the downregulation of antiapoptotic Bcl 2 and survivin but not Bcl XL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
BACKGROUND : Anti apoptotic proteins , such as Bcl 2 and Bcl xL , are frequently over expressed in human malignancies , and this is correlated with resistance to chemotherapeutic drugs and gamma radiation . ^^^ Recently identified small organic molecules capable of inhibiting Bcl 2 and / or Bcl xL function , may enhance radiation sensitivity of cancer cells in which they are over expressed . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
It is believed that oesophageal cancer has an intricate molecular mechanism of evading apoptosis by the down regulation of Bax , up regulation of Bcl 2 , Bcl xl and Survivin , mutation of p 53 and alteration in Fas expression . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
AIMS : To examine the prognostic relevance of the expression of the Bcl 2 , Bcl xL , and Bax proteins in stage IB squamous cervical carcinoma ( SCC ) . ^^^ Immunohistochemistry using monoclonal antibodies against Bcl 2 , Bcl xL , and Bax was used to examine protein expression . ^^^ RESULTS : Cytoplasmic expression of Bcl 2 , Bcl xL , and Bax was low ( < 5 % positive cells ) in 159 of 220 ( 73 % ) , 193 of 220 ( 87 % ) , and 39 of 220 ( 18 % ) tumours , respectively , and high ( > or = 5 % positive cells ) in 61 of 220 ( 27 % ) , 27 of 220 ( 13 % ) , and 181 of 220 ( 82 % ) tumours , respectively . ^^^ CONCLUSION : Bcl 2 , Bcl xL , and Bax were not independently associated with prognosis in stage IB SCC . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Unknotting the roles of Bcl 2 and Bcl xL in cell death . ^^^ The antiapoptotic Bcl 2 family proteins Bcl 2 and Bcl xL play important roles in inhibiting mitochondria dependent extrinsic and intrinsic cell death pathways . ^^^ The overexpression of Bcl 2 may also have the ability to enhance cell death in the interaction of Bcl xL with other factors . ^^^ This review discusses the previously unexplained aspects of Bcl 2 and Bcl xL functions associated with cell death , for better understanding of their functions in the regulation . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Antiapoptotic protein levels of FLICE inhibitory protein , Bcl xL , and Bcl 2 in the liver were significantly lower in sympathectomised mice at one and two hours following Jo 2 treatment than in sham operated animals . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
One of the underlying factors that contribute to cisplatin resistance is the elevated level of BCL 2 and / or BCL XL , which promotes cell survival . ^^^ A potential method of overcoming such resistance is to use a potentiator that is capable of neutralizing the antiapoptotic effects of BCL 2 / BCL XL , such as Siva 1 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
CAR enhanced cell survival was accompanied by reduced activation of caspase 3 and enhanced expression of bcl 2 or bcl XL , depending on the cell type tested . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Immunohistochemical studies revealed intense expression of Bcl 2 and Bcl xL in the hippocampal CA 1 area after 3 NPA treatment . ^^^ Western blot analysis of hippocampus harvested 48 h after the pretreatment , showed that the expression of Bcl 2 and Bcl xL was significantly increased by either 3 NPA treatment or 2 min ischemia . ^^^ These results suggest that Bcl 2 and Bcl xL are essential for acquisition of ischemic tolerance , while HSP 70 and PMCA 1 play important roles in the enhancement of ischemic tolerance . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Also , we found that Bax translocation to mitochondria was associated with the exposure of an NH 2 terminal epitope , and that this translocation could be partially blocked by the prosurvival factors Bcl 2 and Bcl XL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The expressions of dioxin responsive gene cytochrome P 450 1A1 ( CYP1A1 ) , apoptotic gene Bax , and anti apoptotic genes Bcl 2 and Bcl xL were examined in rat liver and brains using Western blot analysis and RT PCR . ^^^ These results indicate that early exposure of dioxin could affect the development of certain brain regions with gender difference , in terms of its differential effect on expressions of Bcl xL , Bcl 2 , and Bax . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Incubation of C 6 glioma cells with thallium acetate upregulated the expression of proapoptotic proteins Bad and Apaf and downregulated the expression of anti apoptotic proteins Bcl xL and Bcl 2 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The purpose of the present study was to explore the seizure induced changes in Bad ( Bcl 2 associated death protein ) , 14 3 3 , phosphoBad , Bcl 2 and Bcl XL expression in the rat model of focal limbic seizure . ^^^ The apoptotic and surviving neurons in the hippocampus were observed by terminal deoxynucleotidyl transferrase mediated dUTP nick end labeling ( TUNEL ) and cresyl violet staining , the expression of Bad , 14 3 3 , phosphoBad , Bcl 2 and Bcl XL were detected with immunofluorescence , Western blot and immunoprecipitation . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Immunohistochemical expression of bcl 2 , bcl xL , bax , p 53 proteins in gastric adenoma and adenocarcinoma ] . ^^^ BACKGROUND / AIMS : The aim of this study was to investigate the immunohistochemical expression of bcl 2 , bcl xL , bax , and p 53 proteins according to the pathological parameters such as grade of dysplasia , histological type , depth of invasion , lymph node metastasis , and TNM stage in the gastric adenoma and gastric adenocarcinoma . ^^^ METHODS : Immunohistochemical staining using monoclonal bcl 2 , bcl xL , bax , p 53 antibodies were performed on paraffin embedded specimens from forty one gastric adenomas and 100 gastric adenocarcinomas . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Regulation of apoptosis in granulosa cells was examined by annexin 5 and propidium iodide staining ; measurement of relative levels of mRNA encoding Bcl 2 , Bcl xL and Bax ; and activity of caspase 3 , 8 and 9 . ^^^ The ratios of relative levels of mRNA encoding Bcl 2 to Bax and Bcl xL to Bax were higher on day 6 than days 4 and 8 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
METHODS : NOS isoenzymes , pro ( Bax ) and antiapoptotic factors ( Bcl 2 , Bcl XL ) , and neurotrophic factors ( brain derived neurotrophic factor , BDNF ; neurotrophin 3 , NT 3 ; fibroblast growth factor 2 , FGF 2 ) were determined by immunoblotting in the EL mouse brain at various developmental stages . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Proteins for Western blot analysis included Fas associated death domain ( FADD ) and caspase 8 for extrinsic pathway , as well as Bcl 2 , Bcl XL , Bax , Bad , Bid , Akt , p Akt , and caspase 9 for intrinsic pathway . ^^^ Levels of FADD , Bax , Bad , and Bid were substantially increased in the TA induced myopathy group , whereas Bcl 2 , Bcl XL , Akt , p Akt , and caspase 9 did not change between control and myopathy groups . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Over expression of Bcl xL , an anti apoptotic Bcl 2 family protein , prevented cell death dragged by HBx . ^^^ Importantly , expression of HBx in Hep3B cells reduced Bcl xL mRNA and protein levels , but did not regulate other Bcl 2 family members . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The antiapoptotic activity of BMP 7 in the LNCaP and C 4 2B cell lines was not associated with a significant alteration in the levels of the proapoptotic protein Bax or the antiapoptotic proteins Bcl 2 , Bcl xl , and 10 linked inhibitor of apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In this study we evaluate the expression of apoptosis related proteins of the Bcl 2 family ( Bcl 2 , Bax and Bcl xL ) in the traumatic penumbra area in correlation with the extent of apoptosis in the rat model of focal cerebral contusion , treated by HBO . ^^^ The pathological study was based on immunohistochemical staining of the brain sections for Bcl 2 , Bax and Bcl xL with quantitative evaluation of staining by image analysis . ^^^ We concluded that the apoptotic mechanisms are important in delayed cell death in TBI and that post traumatic hypoxemia increases the intensity of apoptosis , probably through a decrease in Bcl 2 and Bcl xL expression which normally repress apoptosis . ^^^ The beneficial effect of HBO treatment in our model of brain contusion correlates well with the increased expression of anti apoptotic proteins ( Bcl 2 and Bcl xL ) following treatment and the appropriate decrease in the extent of apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Cultured Nb cells were sensitized to alpha TOS by pre treatment with Bcl 2 , Bcl xL or Mcl 1 siRNAs , while the malignant cell line was more resistant to the vitamin E analogue when Bax was knocked down . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The proapoptotic BH 3 only protein natural born killer / Bcl 2 interacting killer ( Nbk / Bik ) has been described to inhibit Bcl 2 and Bcl xL , thereby supporting the death promoting ability of Bax . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
This combined treatment was also cytotoxic to glioma cells overexpressing Bcl 2 or Bcl xL , but not to normal human astrocytes , thus offering an attractive strategy for safely treating resistant gliomas . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NF kappaB regulated gene products , such as cyclin D 1 , COX 2 , MMP 9 , ICAM 1 , c Myc , survivin , IAP 1 , IAP 2 , XIAP , Bcl 2 , Bcl xL , Bfl 1 / A1 , TRAF 1 and FLIP , were all downregulated by zerumbone . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The antiapoptotic Bcl 2 family proteins , Bcl 2 and Bcl xL , are recognized phototargets of photodynamic therapy ( PDT ) with the mitochondrion targeting phthalocyanine photosensitizer Pc 4 . ^^^ Western blot analysis localized Mcl 1 to mitochondria , ER , and cytosol of both MCF 7c3 and U 937 cells , suggesting that Mcl 1 protein , unlike Bcl 2 and Bcl xL , is not a target for Pc 4 PDT , probably due to its localization to sites removed from those of Pc 4 binding . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Overexpression of wild type SOCS 3 in carcinoma cells with methylated SOCS 3 resulted in the induction of apoptosis and growth suppression as well as downregulation of STAT 3 , bcl 2 as well as bcl xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We evaluated the levels of Bax , Bcl xL , Bcl 2 and cytochrome c expression by Western blot analysis , and caspase 9 and 3 activities were determined in a colorimetric assay . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
This pathway is regulated by bcl 2 family of anti apoptotic ( bcl 2 , bcl xl , mcl 1 ) and pro apoptotic proteins ( bax , bad , bak ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bax , Bcl 2 , Bcl XL , Bid , cytochrome c and PKCd were detected by Western blotting . ^^^ A decreased expression of Bid was noted , although no significant changes in Bax , Bcl 2 and Bcl XL expression were observed after the combined treatment . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
T 3 inhibited the apoptotic process induced by streptozocin , S Nitroso N Acetylpenicylamine ( SNAP ) , and H2O2 via regulation of the pro and anti apoptotic factors Bcl 2 , Bcl XL , Bad , Bax , and Caspase 3 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
RT PCR analysis for apoptosis related gene expression showed that the expression of Bax , Bcl 2 , Bcl xL , and Bcl xs genes , which are implicated in mitochondrial pathway , was significantly upregulated in the testes of the treated rats . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Ellipticine increased the expression of Bax , but decreased the level of Bcl 2 , Bcl XL and 10 linked inhibitor of apoptosis protein ( XIAP ) , and subsequently triggered the mitochondrial apoptotic pathway ( release of cytochrome c , and activation of caspase 9 and 3 ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In the present study , the effects of EtOH on multiple functional mechanisms of Bcl 2 , Bcl xL , and Bax were investigated to characterize further the processes underlying these disparate EtOH sensitivities . ^^^ For these analyses , we addressed the following questions , by using P 4 and P 7 cerebellar tissue following in vivo exposure : 1 ) Are there differential patterns of expression of antiapoptotic Bcl 2 or proapoptotic Bax in EtOH vulnerable Purkinje cells that could contribute to the different degrees of temporal EtOH vulnerability . 2 ) How does EtOH affect intracellular localization of apoptosis related proteins . 3 ) Does cleavage of Bax contribute to EtOH sensitivity . 4 ) Does EtOH differentially modulate cerebellar protein protein interactions of Bcl 2 , Bcl xL , and Bax at the vulnerable vs . the resistant ages . ^^^ Overall , we show that , at P 4 , the EtOH mediated effects on Bcl 2 , Bcl xL , and Bax favor a prodeath response , whereas most of the intracellular responses to EtOH exposure at P 7 promote survival . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Moreover , we found that SARS CoV E protein interacted with Bcl xL in vitro and endogenous Bcl xL in vivo and that Bcl xL interaction with SARS CoV E protein was mediated by BH 3 ( Bcl 2 homology domain 3 ) of Bcl xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Furthermore , TUNEL assay showed that activation of PAR 1 attenuated docetaxel induced apoptosis through the upregulation of the Bcl 2 family protein Bcl xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Antiapoptotic family proteins such as Bcl 2 and Bcl XL function , at least in part , by binding proapoptotic members such as Bax and Bak and thereby prevent release of the apoptotic cascade of events . `` BH 3 only ' ' members of the family disrupt this interaction by binding , via their BH 3 domain , to a hydrophobic pocket on the surface of the antiapoptotic members . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Malfunctions in death pathways observed in human cancers are often due to overexpression of antiapoptotic proteins in the Bcl 2 protein family , i . e . , Bcl 2 , Mcl 1 , and Bcl xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Subsequent studies showed that combined treatment with bortezomib or MG 132 resulted in an increase of death receptor ( DR ) 5 and Bik at protein levels but had no effects on protein levels of DR 4 , Bax , Bak , Bcl 2 , Bcl XL or Flice inhibitory protein ( FLIP ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Inhibition of Akt phosphorylation was coupled with a significant decrease of anti apoptotic Bcl 2 and Bcl XL . ^^^ The decrease of Bcl 2 and Bcl XL along with this oxidative stress caused release of mitochondrial cytochrome c into the cytosol and subsequent induction of pro caspase 9 processing . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Apoptosis by I3C involves downregulation antiapoptotic gene products , including Bcl 2 , Bcl xL , survivin , inhibitor of apoptosis protein ( IAP ) , 10 chromosome linked IAP ( XIAP ) , and Fas associated death domain protein like interleukin 1 beta converting enzyme inhibitory protein ( FLIP ) ; upregulation of proapoptotic protein Bax ; release of micochondrial cytochrome C ; and activation of caspase 9 and caspase 3 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Regulation of Bcl 2 and Bcl xL anti apoptotic protein expression by nuclear receptor PXR in primary cultures of human and rat hepatocytes . ^^^ Using primary cultured human and rat hepatocytes , we investigated to determine if PXR is implicated in the regulation of Bcl 2 and Bcl xL , two crucial apoptosis inhibitors . ^^^ The anti apoptotic capacity of PXR activation was correlated with Bcl 2 and Bcl xL induction at both the transcriptional and protein levels in man and rats , respectively . ^^^ Our results demonstrate that PXR expression is required for Bcl 2 and Bcl xL up regulation upon PXR activators treatment in human and rat hepatocytes . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Our results show that the ITCs caused phosphorylation of Bcl 2 , induced mitochondrial translocation of Bak , and disrupted the association of Bcl xl with both Bak and Bax in mitochondrial membrane , indicating that ITC induced mitochondrial damage results at least in part from modulation of select Bcl 2 family members . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Treatment with arsenic trioxide ( ATO ; 2 200 microM ) inhibited NF kappaB activity in normal marrow , primary MDS , and ML 1 cells , even in the presence of exogenous TNF alpha ( 20 ng / mL ) , and down regulated NF kappaB dependent antiapoptotic proteins , B cell leukemia XL ( Bcl XL ) , Bcl 2 , 10 linked inhibitor of apoptosis ( XIAP ) , and Fas associated death domain ( FADD ) like interleukin 1beta converting enzyme ( FLICE ) inhibitory protein ( FLIP ) , leading to apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The analysis of anti apoptotic and pro apoptotic members of the Bcl 2 family in untreated pancreatic cancer cell lines shows a generalised low expression of Bcl 2 and a strong expression of Bcl xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Overexpression of Bcl xl , a member of the Bcl 2 protein family , is reported to protect from a variety of stresses involving delayed cell death . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The attenuation of cisplatin induced cell death in cyclin D 1 overexpressing cells was correlated with the up regulation of nuclear factor kappaB activity and maintenance of bcl 2 and bcl xl protein levels . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Increased levels of Bcl 2 and Bcl XL proteins have been reported in mammary tumors of COX 2 transgenic mice and in human colon cancer cell lines that have high levels of COX 2 . ^^^ However , we did not observe any changes in Bcl 2 , Bcl XL , or Bax expression induced by COX 2 or PGE 2 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Although neither the total amounts nor the mitochondrial localization of Bax , Bcl 2 and Bcl xL were affected , caspase 3 activity was increased after NMDA exposure . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
NPD 1 repressed Abeta 42 triggered activation of proinflammatory genes while upregulating the antiapoptotic genes encoding Bcl 2 , Bcl xl , and Bfl 1 ( A 1 ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
MATERIALS AND METHODS : The growth of the colo 201 human colon cancer cell line was examined by colorimetric 3 ( 4 , 5 dimethylthiazol 2 yl ) 5 ( 3 carboxymethoxyphenyl ) 2 ( 4 sulphophenyl ) 2H tetrazolium ( MTS ) assay , while the expression of apoptosis and proliferation related proteins ( p 53 , Bax , Bcl xL and S , Bcl 2 , Caspase 8 , Caspase 3 and proliferating cell nuclear antigen ( PCNA ) ) were examined by Western blotting . ^^^ The expression of an apoptosis suppressing protein ( Bcl 2 ) was down regulated , an apoptosis enhancing protein ( cleaved form of Caspase 3 ) was up regulated , proliferation related PCNA protein was down regulated and p 53 , Bax , Bcl xL and S and Caspase 8 levels were unchanged . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Finally , the analysis of the molecular markers that might be implicated in the synergism between LY 294002 and gemcitabine suggests that PI3K inhibition might aid chemotherapeutic treatment , leading to changes in the balance between anti and pro apoptotic molecules of the Bcl 2 family , Bcl XL and Bax . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
DEX treatment upregulated cellular FLICE inhibitory protein ( cFLIP ) expression , but did not alter the protein levels of Bcl 2 , Bcl xL , Mcl 1 , and cIAP as well as Akt activation . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The increased apoptosis in gadd45a and gadd45b deficient cells was evident also by enhanced activation of caspase 3 and poly ADP ribose polymerase cleavage and decreased expression of c inhibitor of apoptotic protein 1 , Bcl 2 , Bcl xL compared to wt cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
To shed light on the relationships between over expression of anti apoptotic proteins , genomic instability , and the metastatic ability of breast cancer cells , we analyzed genetic changes in tumors and metastases by orthotopically injecting MDA MB 435 cells transfected with anti apoptotic genes Bcl xL or Bcl 2 into nude mice . ^^^ Tumors and metastasis variants were extracted by primary culture from breast , bone , lung , and lymph node from mice with 435 / Bcl xL , 435 / Bcl 2 , and 435 / Neo tumors . ^^^ We found that the genetic damage fraction ( GDF ) increased in 435 / Bcl 2 ( GDF=0 . 55 ) and 435 / Bcl xL cells ( GDF=0 . 34 ) , in regard to 435 / Neo control cells ( GDF=0 . 29 ) , indicating that non random genetic alterations occurred in cells secondary to Bcl 2 or Bcl xL over expression . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Apoptin induced cell death is counteracted by the anti apoptotic Bcl 2 family members , Bcl 2 itself and Bcl XL , as shown in Jurkat leukaemia cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Retinamide induced apoptosis in glioblastomas is associated with down regulation of Bcl xL and Bcl 2 proteins . ^^^ Glioblastomas have developed effective mechanisms to resist chemotherapy including levels anti apoptotic proteins , Bcl xL and Bcl 2 . ^^^ Chemotherapy agents that promote down regulation of Bcl xL and Bcl 2 may enhance sensitivity to chemotherapy in glioblastomas . ^^^ Expression of Bcl 2 family member proteins Bcl xL and Bcl 2 were assessed in glioblastomas from three cell lines including U 87 , U 251 , and U 138 . ^^^ Based on Western blots the levels of Bcl 2 and Bcl xL were decreased in glioblastoma cells after treatment with retinamide . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
These findings supported the fact that the inhibitors of caspases , DEVD FMK , IETD FMK and VAD FMK , prevented apoptosis and restored the expression of Bcl XL , Bcl 2 and Bid . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Immunoblotting analysis showed no upregulation of pro apoptotic proteins ( caspase 2L , 3 , 6 , 8 , 9 , and Bax ) with age while all the anti apoptotic proteins ( caspase 2S , Bcl 2 , and Bcl XL ) remained unchanged during aging . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In the present paper , we demonstrate that hydrodynamic gene delivery of IL 22 cDNA driven either by a liver specific albumin promoter or a human cytomegalovirus ( CMV ) promoter results in IL 22 protein expression , STAT 3 activation , and expression of several anti apoptotic proteins , including Bcl xL , Bcl 2 , and Mcl 1 in the liver . ^^^ Western blot analyses show that overexpression of IL 22 significantly enhances activation of STAT 3 and expression of Bcl xL , Bcl 2 , and Mcl 1 proteins in liver injury induced by Con A . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
PSI induced cell death required RNA transcription and protein synthesis , but not DNA replication , was accompanied by the upregulation of Bcl 2 and modest reduction of Bax and Bcl XL proteins , and involved the activation of caspases 2 , 3 , 7 and 8 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 and Bcl xL expressions were down regulated after paclitaxel treatment in FHIT expressing cells , whereas Bax and Bad expressions were up regulated . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Cell differentiation , Caspase inhibition , and macromolecular synthesis blockage , but not Bcl 2 or Bcl XL proteins , protect SH SY5Y cells from apoptosis triggered by two CDK inhibitory drugs . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Curcumin also suppressed the paclitaxel induced expression of antiapoptotic ( XIAP , IAP 1 , IAP 2 , Bcl 2 , and Bcl xL ) , proliferative ( cyclooxygenase 2 , c Myc , and cyclin D 1 ) , and metastatic proteins ( vascular endothelial growth factor , matrix metalloproteinase 9 , and intercellular adhesion molecule 1 ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Further investigation showed that silencing of hPEBP 4 in MCF 7 cells promoted TNF alpha induced stability of p 53 , up regulation of phospho p53ser15 , p21waf / cip , and Bax , and down regulation of Bcl 2 and Bcl xL , which were shown to depend on extracellular signal regulated kinase 1 / 2 and c jun NH 2 terminal kinase activation by hPEBP 4 silencing . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Conditionally BCL xL overexpressing LNT 229 Tet On glioma cell clones were generated to investigate whether the ' antiapoptosis phenotype ' and the ' motility phenotype ' mediated by BCL 2 family proteins in glioma cells could be separated . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
BCL XL , BAX and BCL 2 are members of the BCL 2 protein family known to regulate both apoptotic and necrotic cell death signaling at the mtPTP . ^^^ No significant treatment related alterations in BCL XL , BAX or BCL 2 protein expression are observed in rat tissue homogenates or primary astrocytes . ^^^ However , moderate increases in BCL XL are observed only in DNB treated rat cortical astrocytes , and these increases may be sufficient to shift the constitutive balance in expression of antagonistic to agonistic BCL 2 proteins from a ratio which favors BAX to one in which BAX and BCL XL are comparably expressed . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Nonpeptidic small molecule inhibitor of Bcl 2 and Bcl XL , ( ) Gossypol , enhances biological effect of genistein against BxPC 3 human pancreatic cancer cell line . ^^^ OBJECTIVES : In pancreatic cancer , several important survival molecules such as EGFR , NF kappaB , and Bcl 2 or Bcl XL are highly activated . ^^^ Thus , agents that inhibit NF kappaB activation , together with agents that directly inhibit Bcl 2 or Bcl XL protein function , may lead to enhanced cell killing . ( ) Gossypol , a natural polyphenolic compound isolated from cottonseeds , is a dual and potent small molecule inhibitor of Bcl 2 and Bcl XL proteins , with a Ki value in the 300 600 nM range for both proteins . ^^^ We have previously shown that genistein , a prominent soy isoflavone , transcriptionally down regulates Bcl 2 , Bcl XL , VEGF , MMP 9 , and uPAR via inhibiting NF kappaB activity . ^^^ CONCLUSION : From these results , we conclude that inhibition of NF kappaB activity and direct inhibition of Bcl 2 or Bcl XL function should serve as a novel strategy for pancreatic cancer therapy . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We also highlight some recent discoveries that pave the way for the development of new therapeutic strategies by protecting hepatocytes ( for example by employing Bcl 2 , Bcl XL or A1 / Bfl 1 , IAPs , or synthetic caspase inhibitors ) , or by the induction of apoptosis in stellate cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
HDAC inhibitors enhance the apoptosis inducing potential of TRAIL in leukemia cells ( HL 60 , Jurkat , K 562 , and U 937 ) through multiple mechanisms ; up regulation of DR 4 , DR 5 , Bak , Bax , Bim , Noxa and PUMA , down regulation of IAPs , Mcl 1 , Bcl 2 , Bcl XL and cFLIP , release of mitochondrial proteins ( cytochrome c , Smac / DIABLO and Omi / Htr2 ) to the cytosol , induction of p21WAF1 / CIP1 and p27KIP1 , activation of caspase 3 and cleavage of poly ( ADP ribose ) polymerase ( PARP ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl 2 and Bcl xL are associated with treatment resistance and progression in many cancers , including prostate cancer . ^^^ The objective of this study was to determine whether a novel bispecific antisense oligonucleotide targeting both Bcl 2 and Bcl xL induces apoptosis and enhances chemosensitivity in androgen independent PC 3 prostate cancer cells . ^^^ An antisense oligonucleotide with complete sequence identity to Bcl 2 and three base mismatches to Bcl xL selected from five antisense oligonucleotides targeting various regions with high homology between Bcl 2 and Bcl xL was found to be the most potent inhibitor of both Bcl 2 and Bcl xL expression in PC 3 cells . ^^^ This selected Bcl 2 / Bcl xL bispecific antisense oligonucleotide reduced mRNA and protein levels in a dose dependent manner , reducing Bcl 2 and Bcl xL protein levels to 12 % and 19 % , respectively . ^^^ This Bcl 2 / Bcl xL bispecific antisense oligonucleotide also enhanced paclitaxel chemosensitivity in PC 3 cells , reducing the IC 50 of paclitaxel by > 90 % . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Interestingly , the expression of antiapoptotic proteins Bcl 2 and Bcl xL was initially increased in guggulsterone treated PC 3 cells but declined markedly following a 16 to 24 hour treatment with guggulsterone . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Up regulation of Bad and p 21 ; down regulation of Bcl 2 , Bcl XL , Bid , p 53 , and fatty acid synthase ; and cleavage of Bax were found in HMDB treated A 431 cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
INTRODUCTION : Bcl 2 and Bcl xL confer resistance to apoptosis , thereby reducing the effectiveness of chemotherapy . ^^^ We examined the relationship between the expression of Bcl 2 and Bcl xL and chemosensitivity of breast cancer cells , with the aim of developing specific targeted therapy . ^^^ METHODS : Four human breast cancer cell lines were examined , and the effects of antisense ( AS ) Bcl 2 and AS Bcl xL phosphorothioate oligodeoxynucleotides ( ODNs ) on chemosensitivity were tested in vitro and in vivo . ^^^ RESULTS : Treatment with AS Bcl 2 and Bcl xL ODNs resulted in a sequence specific decrease in protein expression , compared with controls . ^^^ Treatment of MDA MB 231 , BT 474 , and ZR 75 1 cells with AS Bcl xL increased chemosensitivity to DOX , MMC and taxanes to a smaller extent than AS Bcl 2 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Interestingly , GADD 45 family members were also able to bind and enhance cell death suppression by Bcl xL , a member of the Bcl 2 family of cell death suppressors , suggesting a direct cooperative link between apoptosis and the proteins that regulate the DNA damage response . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Here , we report that contrary to previous assumptions , Bcl 2 and Bcl xL inhibit apoptin induced cell death in several tumor cell lines . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Tg betaCTF99 / B6 mouse brain at 12 16 months showed severely down regulated calbindin , phospho CREB , and Bcl xL expression and up regulated phospho JNK , Bcl 2 , and Bax expression . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
As it has been shown for Mcl 1 , Bcl xl and Bcl 2 , proteins of the Bcl 2 family play a crucial role during T cell development in the thymus . ^^^ Therefore , our results suggest that A 1 plays a specialized role in allowing survival of DP thymocytes and that its role can be distinguished from that of Mcl 1 , Bcl xl and Bcl 2 . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
At the same time , p 53 , phospho p 53 ( Ser 15 ) , and other apoptosis related proteins such as Bax , Bcl 2 , Bcl xL , pro caspase 3 , and pro caspase 9 were determined by Western blot analysis . ^^^ An increase in expression of the pro apoptotic factor Bax and a decrease in expression of the anti apoptotic factor Bcl 2 were also observed in a time dependent manner after exposure of 50 microM curcumin , while the expression of the anti apoptotic factor Bcl xL was unchanged . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The anti apoptotic members of the Bcl 2 family , such as Bcl 2 and Bcl XL , play a central role in preventing the induction of apoptosis via the intrinsic apoptotic pathway . ^^^ It has been previously shown that induction of apoptosis by the pro apoptotic Bcl 2 family member Bok is not antagonized by either Bcl 2 or Bcl xL , suggesting that Bok might have a unique role in the apoptotic cascade . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In this study we included aso ' s to known apoptosis modulators ( bcl 2 , bcl xl and survivin ) which were previously identified in HUVEC ' s . ^^^ Clusterin , bcl 2 , bcl xl and survivin aso ' s were all found to inhibit HUVEC growth . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Western blot analysis indicated that the induction of apoptosis by GA and ursolic acid was accompanied with an activation of caspase 8 and a reduction in the anti apoptotic proteins , Bcl 2 and Bcl xL , although the pro apoptotic proteins , Bax and Bak , remained unaffected . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
This was accompanied by significant TRAIL and decreased caspase 3 mRNA expression , whereas the expression of Bcl 2 family members was low ( Bcl xl ) or absent ( Bcl 2 , Bax ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Western blot analysis revealed the down regulation of Bcl 2 and Bcl xL and the up regulation of Bax and Bad by cerebral I / R insult . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We also found that Myc reduces the expression of Bcl 2 and Bcl xL and that the apoptosis inducing stimuli up regulate Bax expression . ^^^ These results suggest that up regulation of mtCLIC , together with a reduction in Bcl 2 and Bcl xL , sensitizes Myc expressing cells to the proapoptotic action of Bax . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
While the expression of Bax , Bak , and Bcl 2 was comparable to the wild type cells , the selected clones showed specific up regulation of Bcl XL , an anti apoptotic protein . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
OBJECTIVES : Thus , in the present study , we studied the effects of systemically administered Epo on antiapoptotic ( bcl 2 , bcl XL ) , proapoptotic ( bax and DP 5 ) gene expression following hypoxic ischemic brain injury in neonatal rats . ^^^ Bcl 2 , bcl XL , bax , and DP 5 mRNA expression were analyzed by RT PCR . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Chi square analysis revealed no association between expression of Bcl 2 , Bcl XL , Bad , Bak , Bid or p 53 proteins and response to vinorelbine therapy . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The levels of adenine nucleotide translocator , voltage anion dependent channel , Bax , Bcl 2 , Bcl xL , AIF and Smac / Diablo , were similar in both cell lines , whereas cytochrome c content was divided by three in the resistant cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Ionizing radiation enhances therapeutic activity of mda 7 / IL 24 : overcoming radiation and mda 7 / IL 24 resistance in prostate cancer cells overexpressing the antiapoptotic proteins bcl xL or bcl 2 . ^^^ Ectopic overexpression of bcl xL and bcl 2 prevents these changes including apoptosis induction in prostate tumor cells by Ad . mda 7 . ^^^ Considering that elevated expression of bcl xL and bcl 2 are frequent events in prostate cancer development and progression , the present studies support the use of ionizing radiation in combination with mda 7 / IL 24 as a means of augmenting the therapeutic benefit of this gene in prostate cancer , particularly in the context of tumors displaying resistance to radiation therapy owing to bcl 2 family member overexpression . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Characterization of the effects of Bcl 2 and Bcl xl deletion mutant expression in cell lines used for antibody production . ^^^ In order to determine if expression of mutant forms of Bcl 2 and Bcl xl could increase viable culture densities and batch MAb yields when compared to parental cell lines , recombinant delta loop deletion mutant of these apoptotic inhibitory genes were expressed in a myeloma and two hybridoma cell lines . ^^^ Expression of either Bcl 2 delta or Bcl xl delta in P3x63Ag8 . 653 myeloma cells did not significantly increase viable cell densities in cultures over time . ^^^ However , the rapid post peak decline in viable cell density was significantly reduced in Bcl xl delta expressing hybridoma cell lines 552 and 7 . 16 . 4 and in Bcl 2 expressing hybridoma 7 . 16 . 4 . ^^^ Annexin staining in hybridoma 7 . 16 . 4 confirmed that apoptosis was the primary means of cell death in this cell line , and expression of Bcl 2 delta and Bcl xl delta inhibited programmed cell death . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Treatment with AGN 194204 and 9 cis retinoic acid significantly decreased apoptosis measured by annexin 5 staining but did not affect expression of Bcl 2 and Bcl xL . ^^^ In summary , these data demonstrate that RXR agonists increase Bcl2a1 promoter activity and increase expression of Bcl2a1 in naive T lymphocytes but do not affect Bcl 2 and Bcl xL expression in naive T lymphocytes . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Expression of pro survival genes bcl 2 and bcl xl was down regulated by 10 % to 60 % ; expression of the proapoptosis gene bax was up regulated by 23 % to 85 % . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
PCP induced reference memory impairment , and a decrease of the ratio of an anti apoptotic Bcl 2 family member ( Bcl XL ) to a pro apoptotic analogue ( Bax ) in the posterior cingulate cortex . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Respect to B cells from young mice the anti mu stimulated aged B cells show similar Bcl 2 and Bcl xL expression but differential kinetic of A 1 degradation and a higher level of cFLIP and FAIM . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The pro apoptotic Bcl 2 family proteins , Bak , Bax , and Bim have been shown to be required for disruption of mitochondria and intrinsic cell death of self reactive B cells whereas the anti apoptotic Bcl 2 , Bcl xL , and Mcl 1 can prevent cell death by interfering with the action of Bax and Bak . ^^^ Bcl 2 and Bcl xL have also been shown to regulate the autophagic cell death pathway that may also play a role in B cell tolerance . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Leukemic cells grown on an adherent layer of MS 5 stromal cells in the presence of ATO were more proliferative and less apoptotic and had increased expression cyclin D 1 , Bcl xL and Bcl 2 and decreased expression of p 21 , likely protecting the leukemic cells from ATO cytotoxicity . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
EXPERIMENTAL DESIGN : Using immunohistochemistry and image analysis , we quantified the levels of phospho Stat 3 ( pY Stat 3 ) , phospho Src ( pY Src ) , epidermal growth factor receptor , HER2 / neu , Ki 67 , estrogen receptor , Bcl 2 , Bcl xL , Survivin , and apoptosis in formalin fixed , paraffin embedded sections from invasive carcinomas and their paired nonneoplastic parenchyma . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Silymarin pre treatment reversed the effect of UV irradiation on the expression of phosphorylated Akt and phosphorylated p 53 ( regulated by Akt activation ) , followed by down regulation of Bax and up regulated expressions of Bcl 2 and Bcl xL proteins in UV irradiated A 375 S2 cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Furthermore , rhR 4 treatments led to the increased expression of Bcl 2 , Bcl XL , survivin , and matrilysin , genes associated with a poor prognosis in advanced CRC . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The down regulation of Trx 2 expression caused a decrease in the protein level of Bcl xL on day 3 , whereas the protein level of Bcl 2 did not change until day 4 , and the mRNA level of Bcl xL was unchanged . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In order to analyse the relationships between regulation of apoptosis and homologous recombination ( HR ) , we overexpressed proapoptotic Bax or only BH 3 Bid proteins or antiapoptotic Bcl 2 or Bcl XL , in hamster CHO cells or in SV 40 transformed human fibroblasts . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Overexpression of hRFI inhibits 5 fluorouracil induced apoptosis in colorectal cancer cells via activation of NF kappaB and upregulation of BCL 2 and BCL XL . ^^^ In order to investigate the molecular function of hRFI in the regulation of 5 FU induced apoptosis in colorectal cancer cells , HCT 116 cells were stably transfected with hRFI or LacZ as a control . hRFI overexpression resulted in cellular resistance to 5 FU through an inhibition of the mitochondrial apoptotic pathway and specific upregulation of Bcl 2 and Bcl XL . ^^^ Inhibition of NF kappaB effectively reversed the resistance to apoptosis as well as the upregulation of Bcl 2 and Bcl XL in the hRFI transfectant , indicating that the activation of NF kappaB is the key mechanism for all these findings . ^^^ Overexpression of hRFI in SW 480 and COLO 320 colorectal cancer cells similarly resulted in resistance to 5 FU with the activation of NF kappaB and upregulation of Bcl 2 and Bcl XL . hRFI might be a novel therapeutic target for gene therapy in colorectal cancer . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Moreover , over expression of Bcl 2 or Bcl xL and expression of dominant negative caspase 9 partially reduced Ukrain induced apoptosis pointing to Bcl 2 controlled mitochondrial signalling events . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Apoptosis was accompanied by cytochrome c release to the cytoplasm and Bax translocation to the mitochondria , while the levels of the anti apoptotic proteins Bcl 2 and Bcl xL remained unchanged . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Apoptosis induced by each TM was associated with a significant ( approximately 400 % ) increase in caspase 8 activity , but no change in caspase 9 activity , and Western analyses revealed a marked up regulation of Fas ( approximately 500 % ) and FADD ( approximately 300 % ) with no change in expression of Bax , Bcl 2 , or Bcl xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
After treatment with oridonin for 48 hr , the percentage of disruption of delta psi m gradually increased in a dose dependent manner along with marked changes of cell apoptosis , and necrotic cells increased remarkably after the cells were treated with oridonin for 72 hr ; Western blotting showed cleavage of the caspase 3 zymogen protein ( 32 kDa ) with the appearance of its 20 kDa subunit when apoptosis occurred ; expression of Bcl 2 and Bcl XL was downregulated remarkably while expression of Bax and Bid was upregulated concurrently after the cells were treated with oridonin for 24 hr . ^^^ We therefore conclude that oridonin has significant antiproliferation effects on HPB ALL cells by induction of apoptosis as well as directly causing cell necrosis and that oridonin induced apoptosis on HPB ALL cells is mainly related to the disruption of delta psi m and activation of caspase 3 as well as downregulation of anti apoptotic protein Bcl 2 , Bcl XL , and upregulation of pro apoptotic proteins Bax and Bid . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Each agent induced apoptosis and their combined treatment enhanced apoptosis associated with the down regulation of antiapoptotic proteins , Bcl 2 and Bcl xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
TSA treatment repressed the transcription and downregulated the expression of the antiapoptotic Bcl 2 proteins ; Bcl 2 and Bcl XL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Cell cultures representing two human sarcomas ( FU SY 1 SS and the pleomorphic SW 982 ) and a primary human dermal fibroblast comparator ( NHDF ) were exposed in vitro to doxorubicin , or to doxorubicin preceded by Bcl 2 ( G 3139 ) antisense oligonucleotides , and assayed for cell survival , apoptosis , and modulations in Bcl 2 and Bcl xL mRNA and protein content . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In this study , we demonstrate that NF kappaB is constitutively activated in various HTLV 1 infected T cell lines and ATL derived cell lines irrespectively of Tax expression as evidenced by the phosphorylation of IkappaBalpha and p 65 subunit of NF kappaB , activation of NF kappaB DNA binding , and upregulation of various target genes including bcl xL , bcl 2 , XIAP , c IAP 1 , survivin , cyclinD 1 , ICAM 1 and VCAM 1 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl xL and bcl 2 proteins in melanoma progression and UVB induced apoptosis . ^^^ Whether bcl xL and bcl 2 play an essential role in melanoma progression and UVB induced apoptosis is not completely understood . ^^^ We investigated the expression of bcl xL and bcl 2 in matched primary and metastatic melanoma tumors and melanoma cell lines from the same melanoma patients to clarify the importance of bcl xL and bcl 2 in melanoma progression and in UVB induced apoptosis . ^^^ The expression of bcl xL and bcl 2 proteins was examined by immunohisto ( cyto ) chemistry and Western blot in melanoma tumors and melanoma cells . ^^^ Both primary melanoma tumors and melanoma cells showed lower expression of bcl xL and bcl 2 proteins estimated as frequency of positive cells than their matched metastatic tumors and cells in vitro . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Levels of proapoptotic factors ( bim and bax ) increased and levels of antiapoptotic factors ( bcl 2 and bcl xL ) decreased in a dose dependent manner . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The oncogenic Vav 1 induced apoptosis is associated with reduced expression of Bcl 2 and Bcl xL proteins and effectively suppressed by transgenic overexpression of Bcl 2 , suggesting Vav 1 mediated signaling via Bcl 2 in apoptosis . ^^^ Further , when expressed in the p 53 deficient cells , which express elevated Bcl 2 and Bcl xL and are resistant to the apoptosis , oncogenic Vav 1 enhances both proliferation and self renewal of hematopoietic progenitor cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Resveratrol also down regulated the expression of NF kappaB regulated gene products by Western blot analysis , gelatin zymography , and enzyme linked immunosorbent assay , including interleukin 6 , Bcl 2 , Bcl xL , XIAP , c IAP , vascular endothelial growth factor ( VEGF ) , and matrix metalloproteinase 9 ( MMP 9 ) , which modulates an array of signals controlling cellular survival and proliferation and tumor promotion . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
IL 6 administration initially induced expression of the anti apoptotic proteins Bcl 2 and Bcl xL , correlating with protection against Fas mediated cell death . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Active p 38 MAPK phosphorylates Bcl xL and Bcl 2 and prevents the accumulation of these antiapoptotic molecules within the mitochondria . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We also show evidence suggesting that IAN 4 and IAN 5 are associated with anti apoptotic proteins Bcl 2 and Bcl xL , whereas IAN 1 is associated with pro apoptotic Bax . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
This sensitizing effect is lost if Bcl 2 expression , but not Bcl xL expression , is knocked down or if cells only express a mutant of Bax that does not interact with Bcl 2 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Tocopheryl succinate induces apoptosis in prostate cancer cells in part through inhibition of Bcl xL / Bcl 2 function . ^^^ This study provides evidence that inhibition of Bcl xL / Bcl 2 function represents a major pathway whereby alpha tocopheryl succinate mediates apoptosis induction in prostate cancer cells . ^^^ In vitro data indicate that alpha tocopheryl succinate was able to disrupt the binding of Bak BH 3 peptide to Bcl xL and Bcl 2 with IC 50 of 26 microm , in line with its potency in antiproliferation . ^^^ Treatment of PC 3 cells with this agent led to reduced association of Bcl 2 and Bcl xL with Bak , leading to caspase dependent apoptosis . ^^^ This mechanistic finding provided a basis to develop potent Bcl xL / Bcl 2 inhibitors . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Treatment with 0 . 4 mmol / L H ( 2 ) O ( 2 ) up regulated Bax but down regulated Bcl 2 in a time dependent manner , while Bcl xL expression remained unchanged . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Death promoting Bcl 2 family members , such as Bax , can promote cytochrome c release and fragmentation of the mitochondrial network , whereas apoptosis inhibitory members , such as Bcl 2 and Bcl xL , can antagonize these events . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The up regulated expression of Bcl 2 , Bcl xL and the cellular FLICE inhibitory protein ( c FLIP ) in fluoxetine treated NSCs was detected by real time RT PCR . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In addition , the results showed that FME induced apoptosis was accompanied by up regulation of Bax and Bad , and down regulation of Bcl 2 and Bcl XL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
RESULTS : Our results indicated that combined treatment led to an increased apoptotic cell death in U 937 cells , which is correlated with the phosphorylation of the 5 Jun sarcoma virus 17 oncogene homolog ( c JUN ) NH ( 2 ) terminal kinase protein ( JNK ) , the activation of caspases , the increase in B cell leukemia / lymphoma 2 ( Bcl 2 ) associated 10 protein ( Bax ) , the decrease in Bcl xL protein ( Bcl XL ) levels , the loss of mitochondria membrane potential and the release of cytochrome c . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Treatment of cells with cerulenin and LY 294002 down regulated the protein levels of 10 chromosome linked inhibitor of apoptosis ( XIAP ) , cellular inhibitor of apoptosis 1 ( cIAP 1 ) , and Akt , whereas the levels of mitogen activated protein / extracellular signal regulated kinase kinase and other antiapoptotic Bcl 2 family proteins ( Bcl 2 and Bcl xl ) did not change . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
MAIN OUTCOME MEASURES : Expression of p 16 , p 21 , p 53 , Bcl xL , Bcl xS , p 27 , DP 1 , MDM 2 , Bcl 2 , c Jun , and Jun D were assessed using Western blot analysis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In the present study , we showed that stimulation of normal CD4+ T cells with jacalin plus CD 28 cross linking ( CD28XL ) resulted in phosphorylation of signal transducer and activator of transcription ( STAT ) 6 and expression of Bcl 2 and Bcl xL , which were inhibited significantly when cells were cultured in the presence of the p 38 mitogen activated protein kinase ( MAPK ) inhibitor SB 203580 . ^^^ We further generated jacalin induced CD4+ T cell blasts , examined the effects of CD28XL , and observed enhanced up regulation of p 38 and activation of STAT 6 , Bcl 2 , and Bcl xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Immunohistochemistry was employed to examine the expression of the antiapoptotic proteins Bcl 2 and Bcl XL and the proapoptotic proteins Bad , Bak , Bax , Bid , Bim , and p 53 in 21 cases of gastric cancer . ^^^ Immunopositivity was observed in 12 / 21 ( 57 % ) cases for p 53 , 16 / 21 ( 76 % ) cases for Bcl XL , and 5 / 21 ( 23 % ) cases for Bcl 2 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
To gain a broader insight into the role of Bcl 2 proteins in apoptosis induced after mitotic arrest , we investigated the subcellular location , oligomeric structure , and protein interactions of Bax , Bcl 2 , and Bcl xL in vinblastine treated KB 3 cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
MnTmPyP inhibited antiapoptotic gene expression ( Bcl 2 and Bcl xL ) during early rejection but restored expression at later stages . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The authors tried to determine the responsible molecules ; however , expression of TRAIL receptors ; pro caspase 3 / 8 / 9 ; Fas associated death domain protein ( FADD ) ; tumor necrosis factor receptor 1 associated death domain protein ( TRADD ) ; silencer of death domain ( SODD ) ; FLICE inhibitory protein ( FLIP ) ; and Bcl 2 , Bcl xL , and Bax in FLS was not modulated by IFN gamma . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In this study , we report that oral nickel administration increased the nickel content of splenic Ni ( high ) B cells and up regulated their Fas expression while down regulating expression of bcl 2 and Bcl xL , thus giving rise to an Ag carrying , apoptosis prone B cell phenotype . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
As a result , we identified four genes ( Bcl 2 , Bcl XL , cIAP 2 , and CFLAR ) whose expression was four or more times higher in HCT116 / hRFI cells than in HCT116 / LacZ cells , and found that Bcl 2 and the ratio of Bcl 2 / Bax or Bcl 2 / Bak were upregulated when HCT116 / hRFI cells were treated with 5 FU . ^^^ Furthermore , we also validated the up regulation of Bcl 2 and Bcl XL in HCT116 / hRFI cells treated with 5 FU by Western blot analysis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The rapid drop in Vbeta3+ CD4+ T cells in CD 28 / mice was attributable to upregulated induction of apoptosis owing to marginal inductions of Bcl 2 and Bcl xL . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
ALK 7 ca induced the expression of proapoptotic factor Bax but suppressed the expression of antiapoptotic factors Bcl 2 , Bcl XL , and Xiap . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The protein expressions of Bcl XL , Bcl 2 , Bax , cytochrome c and AIF were studied by Western blotting . ^^^ This was accompanied by down regulation of Bcl XL and Bcl 2 and up regulation of Bax . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In additional studies , treatment of A 431 cells with berberine ( 15 75 microM ) for 72 h resulted in a significant dose dependent increase in apoptosis ( 31 60 % , P < 0 . 05 0 . 001 ) than non berberine treated control ( 11 . 7 % ) , which was associated with an increased expression of pro apoptotic protein Bax , decreased expression of anti apoptotic proteins Bcl 2 and Bcl xl , disruption of mitochondrial membrane potential , and activation of caspases 9 , 3 and poly ( ADP ribose ) polymerase . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In this study , we determined whether the anti apoptotic agent Bcl xL , a member of the Bcl 2 family which prevents programmed cell death in the central nervous system , can rescue oxytocin ( OT ) and vasopressin ( VP ) MCNs in the supraoptic nucleus ( SON ) in organotypic culture . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Molecular mechanism of cell death was investigated by p 53 , Bcl xL , Bcl 2 , Bax protein , activity of caspase 3 and 12 , and activity of telomerase . ^^^ CIZAR reduced expression of Bcl 2 and Bcl xL proteins but induced expression of Bax protein . ^^^ CIZAR ( R ) prevents the proliferation of OVCAR 3 cells by inactivation of m aconitase activity and induces apoptosis by induction of proapoptotic gene ( Bax ) , repression of antiapoptotic genes ( Bcl 2 , Bcl xL ) , and consequently activation of caspase 3 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Plumbagin down regulated the expression of NF kappaB regulated anti apoptotic ( IAP 1 , IAP 2 , Bcl 2 , Bcl xL , cFLIP , Bfl 1 / A1 , and survivin ) , proliferative ( cyclin D 1 and COX 2 ) , and angiogenic ( matrix metalloproteinase 9 and vascular endothelial growth factor ) gene products . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
There was no evidence that calpain cleaved Bcl 2 family member proteins that regulate mitochondrial membrane permeability including Bcl 2 , Bcl xl , Bad , Bak , Bid , or Bim . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The patterns of expression of the Bcl 2 , Bax , and Bcl xL proteins were examined immunocytochemically in rat hippocampus and neocortex after severe hypobaric hypoxia ( 180 Torr for 3 h ) and severe hypoxia preconditioned by intermittent mild hypoxia ( 360 Torr for 2 h daily , for 3 consecutive days , 24 h prior to severe hypoxia ) . ^^^ The preconditioning to severe hypoxia protected neurons from the posthypoxic apoptotic transformations , the up regulation of Bax expression , and resulted in persistent overexpression of Bcl 2 and Bcl xL . ^^^ We conclude that the protective action of hypoxic preconditioning is at least in part mediated by shifting of neuronal Bax / Bcl 2 Bcl xL ratio to a favor of antiapoptotic proteins Bcl 2 and Bcl xL . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Surgical injury affected the expression of apoptosis related genes Bcl 2 , Bax , Bcl xL and Bcl xS , inducing a mean 3 . 5 fold decrease in the Bcl 2 / Bax ratio and a 9 fold decrease in the Bcl xL / S ratio 4 h after injury as compared with uninjured carotid arteries . ^^^ The imbalance between proliferative stimulus represented by surgery and the c myc mRNA decrease induced greater apoptosis in AS ODN treated carotid arteries without further affecting mRNA levels of Bcl 2 , Bax , Bcl xL and Bcl xS genes . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The lipid cardiolipin , that is enriched at mitochondrial contact sites and reported to be important for the localization of Bcl 2 proteins , did not affect the solution to membrane conformational change of the cytosolic domain , suggesting that this lipid is not involved in the localization of Bcl xL in vivo . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
PAF increased the expression of mRNA and the protein synthesis of antiapoptotic factors , such as Bcl 2 and Bcl xL , but did not increase the expression of the proapoptotic factor , Bax . ^^^ Furthermore , PAF inhibited etoposide induced increases in caspase 3 , caspase 8 , and caspase 9 activities , as well as cell death . p50 / p65 heterodimer increased the mRNA expression of Bcl 2 and Bcl xL and decreased etoposide induced caspase activities and cell death . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Induction of apoptosis and enhancement of chemosensitivity in human prostate cancer LNCaP cells using bispecific antisense oligonucleotide targeting Bcl 2 and Bcl xL genes . ^^^ OBJECTIVE : To determine whether a specifically designed bispecific ( Bcl 2 / Bcl xL ) antisense oligonucleotide ( ASO ) induces apoptosis and enhances chemosensitivity in human prostate cancer LNCaP cells , as Bcl 2 and Bcl xL are both anti apoptotic genes associated with treatment resistance and tumour progression in many malignancies , including prostate cancer . ^^^ MATERIALS AND METHODS : Inhibition of Bcl 2 and Bcl xL expression by the bispecific ASO was evaluated using real time reverse transcription polymerase chain reaction and Western blotting , while growth inhibition and induction of apoptosis were analysed by a crystal violet assay , flow cytometry and Western blotting of apoptosis relevant proteins . ^^^ RESULTS : Bispecific ASO reduced Bcl 2 and Bcl xL expression in LNCaP cells in a dose dependent manner . ^^^ Interestingly , Bcl 2 / Bcl xL bispecific ASO treatment also resulted in the down regulation of Mcl 1 and up regulation of Bax . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In the present study , we used quantitative real time reverse transcriptase polymerase chain reaction ( RT PCR ) to determine the effects of 50mM ethanol and 100nM of ipsapirone , a 5 HT ( 1A ) agonist , on the expression of several NF kappaB dependent antiapoptotic genes : 10 linked inhibitor of apoptosis protein ( XIAP ) , cIAP 1 , cIAP 2 , Bcl 2 , and Bcl xl . ^^^ The results demonstrate that ethanol reduces the expression of several prosurvival genes : XIAP , cIAP 1 , cIAP 2 , Bcl 2 , and Bcl xl . ^^^ Although ipsapirone treatment decreased the expression of cIAP 1 , Bcl 2 , and Bcl xl in control neurons , our prior studies suggest that their survival is not reduced by ipsapirone . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We show that the antiapoptotic proteins BCL 2 , BCL XL , MCL 1 , BFL 1 , and BCL w each bear a unique pattern of interaction with a panel of peptides derived from BH 3 domains of BH 3 only proteins . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The proapoptotic proteins Bax and Bak are required for MOMP , while the antiapoptotic Bcl 2 proteins , including Bcl 2 , Bcl xL , Mcl 1 , and others , prevent MOMP . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Here , we show that tuberin triggers apoptosis , accompanied by downregulation of p70S6K activity and of phosphorylation of BAD on residue Ser 136 , and by upregulation of the interaction of BAD / BCL 2 and BAD / BCL XL . ^^^ Our work proposes a model in which tuberin mediated inhibition of p70S6K activates BAD to heterodimerize with BCL 2 and BCL XL to promote apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The purpose of the present study was to analyse the effects of naltrexone on the expression levels of proteins regulating the extrinsic ( FasL and Fas ) and the mitochondrial ( Bcl 2 , Bcl xL , Bad and Bax ) apoptotic pathways , as well as the active fragment of the executioner caspase 3 in the mouse brain . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
HPMA copolymer bound doxorubicin induced a time dependent decrease in the expression of the anti apoptotic Bcl 2 and Bcl xL proteins , which control cell survival . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
TSA reduced FLICE inhibitory protein ( FLIP ) expression but not Bcl 2 , Bcl XL , and Fas expression , indicating that the synergistic effect may be through downregulation of FLIP . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
For anti apoptotic proteins , overexpression was recorded as follows : Bcl 2 40 % ( 22 / 54 ) , Bcl XL 24 % ( 13 / 54 ) , Mcl 1 92 % ( 50 / 54 ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Apop 1 induced apoptosis is not blocked by Bcl 2 or Bcl xL , inhibitors of Bax / Bak dependent channels , whereas it is completely blocked by cyclosporin A , an inhibitor of permeability transition pore . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We also found that indirubin inhibited the expression of NF kappaB regulated gene products involved in antiapoptosis ( IAP 1 , IAP 2 , Bcl 2 , Bcl xL , and TRAF 1 ) , proliferation ( cyclin D 1 and c Myc ) , and invasion ( COX 2 and MMP 9 ) . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In persistently infected cells at 50h . p . i . , PI3K / Akt , JNK , p 38 MAPK and Bcl 2 were phosphorylated and the protein levels of Bcl 2 and Bcl xL were increased . ^^^ These results indicated that at least four proteins , Akt , JNK , Bcl 2 and Bcl xL , are necessary for survival of persistently SARS CoV infected cells . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Radiation therapy induced changes in apoptosis and its major regulatory proteins , Bcl 2 , Bcl XL , and Bax , in locally advanced invasive squamous cell carcinoma of the cervix . ^^^ The major apoptotic regulatory molecules include Bcl 2 , Bcl XL ( antiapoptotic ) , and Bax ( proapoptotic ) proteins . ^^^ The TUNEL assay was performed to detect apoptotic nuclei and Bcl 2 , Bcl XL , and Bax proteins detected by immunohistochemistry ( IHC ) . ^^^ CONCLUSIONS : RT for invasive squamous cell carcinoma of cervix results in increased apoptotic cell death with the up regulation of Bax , a proapoptotic protein , and the down regulation of Bcl XL , an antiapoptotic protein , without any significant change in the levels of Bcl 2 . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In cultures treated with cruzipain , cleavage of caspase 3 was considerably diminished after serum starvation ; Bcl 2 overexpression was inhibited by PD 098059 but not by Ly 294002 , whereas Bad phosphorylation and Bcl xL expression were increased and differentially modulated by both inhibitors . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
RESULTS : At a 5 10 microM dose level , ( ) gossypol significantly enhanced apoptosis measured by DNA fragmentation . ( ) Gossypol caused apoptosis in DU 145 cells through the down regulation of Bcl 2 and Bcl xL and the up regulation of Bax at the mRNA and protein levels . ( ) Gossypol also activated caspases 3 , 8 and 9 and increased PARP [ poly ( ADP ribose ) polymerase ] cleavage . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The drug effects on the expression of the beta tubulin isotypes , Bcl 2 , Bax , Bcl XL and proteomic profiles were evaluated by immunobloting and SELDI mass spectrometry in tumor xenografts dosed at 0 . 5 MTDs . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
KGF exhibited mitogenic and anti apoptotic effects that correlated with induction of cyclin D 1 , Bcl 2 , Bcl xL and phospho Akt expression in PCSCs , where treatment with KGF antiserum abolished cell proliferation and anti apoptotic protein expression . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
To determine the impact of this p 53 activity on normal tissue radiosensitivity , we isolated a small molecule named pifithrin mu ( PFTmu , 1 ) that inhibits p 53 binding to mitochondria by reducing its affinity to antiapoptotic proteins Bcl xL and Bcl 2 but has no effect on p 53 dependent transactivation . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Starting at 6 h , the apoptotic index increased in a time dependent manner , in correlation with the expression of HIF 1alpha , Bcl 2 , Bcl xL , Bax and cleaved Caspase 9 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The protein expression ratio of Bcl xL / Bax and Bcl 2 / Bax was down regulated and uncarinic acid E induced apoptosis involves the initial phase mediated by the balance among Bcl xL , Bcl 2 and Bax proteins , resulting in cytochrome c release from the mitochondria . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Bcl XL is qualitatively different from and ten times more effective than Bcl 2 when expressed in a breast cancer cell line . ^^^ BACKGROUND : Bcl 2 and Bcl XL are anti apoptotic paralogues that inhibit apoptosis elicited by a wide variety of stimuli , and play critical roles in cancer development and resistance to treatment . ^^^ It has therefore been assumed that in cells the essential difference between Bcl 2 and Bcl XL involves regulation of expression and that they are otherwise functionally similar . ^^^ To examine this issue , we have compared the function of the proteins and of mutants of Bcl 2 and Bcl XL specifically targeted to different subcellular sites . ^^^ METHODS : We generated clones of the human breast cancer line MCF 7 stably expressing known amounts of Bcl 2 , or Bcl XL as determined by quantitative immunoblotting . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
This change in Bcl 2 conformation led to the release of cyto c in the presence of Bcl 2 and Bcl xL in reconstituted proteoliposomes . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
JSI 124 decreased the phosphorylated STAT 3 and Janus kinase 3 ( JAK 3 ) levels in a dose dependent fashion , and these changes were coupled with significant decreases in several STAT 3 downstream targets , including mcl 1 , bcl 2 , bcl xL and cyclin D 3 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In cell death models induced by serum withdrawal in rat PC 12 cells and human SH SY5Y neuroblastoma cells , both rasagiline and propargylamine exerted neuroprotective and neurorescue activities via multiple survival pathways , including : stimulation of protein kinase C ( PKC ) phosphorylation ; up regulation of protein and gene levels of PKCalpha , PKCepsilon and the anti apoptotic Bcl 2 , Bcl xL , and Bcl w ; and up regulation of the neurotrophic factors , BDNF and GDNF mRNAs . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Prognostic significance of Bcl 2 , Bcl xL / S , Bax and Bak expressions in colorectal carcinomas . ^^^ The immunohistochemical expressions of the apoptosis related proteins Bcl 2 , Bcl xL / S , Bax and Bak were investigated in tumor specimens selected from 58 consecutive patients undergoing surgery for advanced colorectal carcinoma . ^^^ In the normal colonic mucosa , Bcl 2 positive epithelial cells tended to be located at the base of the crypts , while the Bcl xL / S , Bax and Bak positive epithelial cells tended to be located at the luminal surface . ^^^ The intracellular expression patterns of Bcl 2 and Bax were diffuse cytoplasmic , whereas those of Bcl xL / S and Bak were granular cytoplasmic . ^^^ In the adenocarcinomas , the intracellular expression patterns of all antibodies were diffuse cytoplasmic , and the percentages of Bcl 2 , Bcl xL / S , Bax and Bak positive cases ( > 20 % of cancer cells labeled ) were 29 % , 43 % , 45 % and 69 % , respectively . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
As2O3 had no effect on the expression of the apoptosis related genes like Bcl 2 , Bcl xL / S , Bax , ICH 1L , p 53 , PARP , either , but downregulated PML protein expression in K 562 cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
E1B19K and p 35 were also coinjected with Bcl Xs which blocks Bcl 2 function in lymphoid cells . ^^^ Although Bcl Xs blocked the ability of Bcl 2 to rescue neurons , it had no effect on survival that was dependent upon expression of E1B19K or p35 . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Northern and Western analysis revealed high levels of Bax and p 53 , and low or undetectable levels of Bcl 2 and Bcl xS under all treatment condition . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The expression of genes involved in cell death ( MA 3 , p 53 , Bad , and Bcl xS ) seems to be elevated , whereas the expression of genes involved in cell survival ( Bcl 2 ) is reduced . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Furthermore , apoptosis in Ha ras transformed brown adipocytes is concurrent with an up regulation in the expression of the pro apoptotic protein Bcl xS , the expression of the anti apoptotic protein Bcl 2 being down regulated . ^^^ Thus , we propose a mechanism of apoptosis in Ha ras transformed adipocytes under serum deprivation involving Raf 1 association with phosphorylated Bcl 2 , down regulation of Bcl 2 expression , and up regulation of Bcl xS expression . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
These results indicate that the activation of bcl 2 family genes such as bcl Xs and bax plays a crucial role in modulating apoptotic cell death in the sensitivity to anticancer drugs , and suggest that these proapoptotic genes might interact in the up regulation for activating downstream signals leading to apoptosis in gastric cancer cells . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
In HepG 2 cells that possessed wild type p 53 , CD 437 induced S phase arrest and apoptosis were accompanied by the up regulation of cyclin A , cyclin B , p 53 , p 21 ( CIP1 / Waf1 ) , Bad , and Bcl Xs proteins and by a decrease in Bcl 2 protein levels . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Results from Western blot analysis indicated that HepG 2 cells did not express either the death repressor Bcl 2 , or the death promoters Bcl XS and Bax . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Changes in the relative expression level of Bcl 2 family proteins , including Bak and Bcl Xs , are also observed during p84N5 induced apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Furthermore , TPA exposure of U 937 cells is associated with increased levels of the pro apoptotic proteins Bak and Bcl xs , whereas simultaneously a decline in the Bcl 2 expression was noticable . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The expression of bcl 2 at mRNA and protion level was decreased while that of bcl xs transcription was increased after taxol treatment . ^^^ Bcl 2 and bcl xs are involved in the regulation of taxol induced apoptosis . . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We examined the effects of cadmium on the bcl 2 family of proteins bcl 2 , bax , bad , and bcl xS / L in cadmium induced cytotoxicity . ^^^ Western blot analyses revealed that cadmium markedly increased endogenous bcl 2 protein ( to 3 4 times the level in wild type cells ) earlier than metallothionein induction , but that the metal did not enhance the induction of bax , bad , or bcl xS proteins . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Changes ( mRNA , protein ) in expression of major proapoptotic p 53 , p21WAF1 / CIP1 , bax , bcl Xs genes , and the antiapoptotic bcl 2 gene were observed in malignant MCF 7 and MDA MB 231 cells and in benign MCF 10a human mammary tumor cells in culture . ^^^ Apparent antiapoptotic effects of increased bcl 2 expression in MDA MBA 231 cells were countered by increased proapoptotic p21WAF1 / CIP1 , Bax , and Bcl Xs proteins . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
A survey of molecules involved in TRAIL or Bax mediated apoptotic pathways showed no significant change in expression of death receptors , death decoy receptors ; FLIP ; Bcl 2 ; Bcl xS ; Bax ; Bak ; XIAP or caspase 2 , 7 , 8 , or 9 in either DLD1 / Bax R or DLD1 / TRAIL R cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Furthermore , Bcl 2 family members Bad , Bak , and Bcl xS protein levels were increased in FHIT transfected clones when compared with Panc 1 cells . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Regarding the antiapoptotic mechanisms , we have previously demonstrated that under staurosporine treatment , HalphaA and HalphaB crystallins can interact with Bax and Bcl XS , proapoptotic members of the Bcl 2 family , to sequester their translocation into mitochondria , and thus prevent the staurosporine induced apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
We report here that type 5 collagen is able to determine an increase in the percentage of Apoptag positive cells , to up regulate Bcl xS , Bad , Dap kinase , hsf 1 , mthsp 75 , caspase 1 , 5 , 8 , 9 , and 14 , whilst down regulating Bcl 2 , Bcl xbeta , and hsp 60 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Regarding the antiapoptotic mechanisms , we have previously demonstrated that under staurosporine treatment , HalphaA and HalphaB crystallins can interact with Bax and Bcl XS , proapoptotic members of the Bcl 2 family , to sequester their translocation into mitochondria , and thus prevent the staurosporine induced apoptosis . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The expression of apoptosis related genes BCL 2 , BAX , BCL2L1 , BCL2A1 , MCL 1 , DAPK 1 and MYC was studied by quantitative real time polymerase chain reaction on total RNA samples from patients with acute lymphoblastic leukaemia ( ALL , n = 16 ) , acute myeloid leukaemia ( AML , n = 27 ) , chronic myeloid leukaemia ( CML , n = 12 ) , mantle cell lymphoma ( MCL , n = 19 ) and chronic lymphoid leukaemia ( CLL , n = 32 ) . ^^^ BCL 2 , BCL2L1 , BCL2A1 and MCL 1 were overexpressed and DAPK 1 was underexpressed in CLL samples with a 11q23 deletion . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
This work describes the isolation of cDNA and genomic fragments from five sheep BCL 2 related genes : BCL 2 , BCL2L1 , BCL2L2 , BAX and MCL 1 . ^^^ Three cattle BAC probes containing the homologous BCL 2 , BCL2L1 and BCL2L2 genes were identified and used for comparative FISH mapping in sheep . ^^^ BCL 2 was localised in OAR23q27 , BCL2L1 in OAR13q22 and BCL2L2 in OAR7q15 > q 21 . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
The expression levels of antiapoptotic regulatory proteins ( BCL 2 and BCL2L1 ) and enzymes involved in apoptosis ( caspases 3 , 6 , 7 , 9 , and 10 ) were assessed by immunoblotting throughout gestation and postpartum . ^^^ Levels of BCL 2 were high during early gestation , followed by significantly elevated levels of BCL2L1 at midgestation . ^^^
Interacting proteins: Q07817 and P10415	Pubmed	SVM Score :0.0
Assignment of the bovine B cell CLL / lymphoma 2 gene ( BCL 2 ) to BTA24q27 and the bovine BCL 2 like 1 gene ( BCL2L1 ) to BTA13q22 by in situ hybridization . ^^^