| Interacting proteins: P07384 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07384 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07384 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07384 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07384 and Q07817 |
Pubmed |
SVM Score :0.0 |
| RT PCR detected high levels of Bcl xL in 16 / 23 B CLL and in 8 / 11 MCL in leukaemic phase , whereas Bcl xS was detectable in low to trace amounts respectively in 13 / 23 B CLL and in 6 / 11 MCL in leukaemic phase . ^^^ |
|
| Interacting proteins: P07384 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Bcl 10 was expressed in almost all BL cells , but in few tumour cells in FCL F and in MCL . c Myc , in contrast , was found in the majority of the tumour cells in FCL F and in MCL , but not in BL . ^^^ |
|
| Interacting proteins: P07384 and Q07817 |
Pubmed |
SVM Score :0.0 |
| To investigate its role in MCL we have analyzed a series of 15 MCL for deletion and mutation of BCL 10 . ^^^ In none of the 15 MCL cases studied were mutations found in the BCL 10 coding region . ^^^ Our results strongly suggest that BCL 10 is not the candidate tumor suppressor gene inactivated by deletion or mutation in band 1p22 in MCL . . ^^^ |
|
| Interacting proteins: P07384 and Q07817 |
Pubmed |
SVM Score :0.0 |
| We have investigated whether subsets of indolent B cell non Hodgkin ' s lymphoma ( IB NHL ) differ in the expression of the bcl 2 family members ; 116 cases of IB NHL , composed of chronic lymphocytic leukemia ( CLL , n = 48 ) , follicular lymphoma ( FL , n = 38 ) , marginal zone B cell lymphoma ( MZBCL , n = 15 ) , and mantle cell lymphoma ( MCL , n = 15 ) , were investigated for expression of bcl 2 , bcl 10 , mcl 1 , bax , and bak proteins by immunohistochemistry . ^^^ |
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| Interacting proteins: P07384 and Q07817 |
Pubmed |
SVM Score :0.0 |
| All cell lines express high levels of cyclin E , c Myc , Bcl 2 , Bax , Bcl 10 ( L ) , and Mcl 1 . ^^^ |
|
| Interacting proteins: P07384 and Q07817 |
Pubmed |
SVM Score :0.0 |
| In addition , other proteins of the BCL family are overexpressed in MCL like BCLX , whereas the expression of BAX and BAK was not elevated in MCL . ^^^ |
|
| Interacting proteins: P07384 and Q07817 |
Pubmed |
SVM Score :0.0 |
| The expression of apoptosis related genes BCL 2 , BAX , BCL2L1 , BCL2A1 , MCL 1 , DAPK 1 and MYC was studied by quantitative real time polymerase chain reaction on total RNA samples from patients with acute lymphoblastic leukaemia ( ALL , n = 16 ) , acute myeloid leukaemia ( AML , n = 27 ) , chronic myeloid leukaemia ( CML , n = 12 ) , mantle cell lymphoma ( MCL , n = 19 ) and chronic lymphoid leukaemia ( CLL , n = 32 ) . ^^^ BCL2L1 was underexpressed in CLL and CML , but not in AML , ALL and MCL . ^^^ BCL 2 , BCL2L1 , BCL2A1 and MCL 1 were overexpressed and DAPK 1 was underexpressed in CLL samples with a 11q23 deletion . ^^^ |
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