| Interacting proteins: Q07817 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and P00519 |
Pubmed |
SVM Score :0.0 |
| Tyrosine phosphorylation level of P 210 ( BCR / ABL ) and Bcl 10 ( L ) was decreased . ^^^ |
|
| Interacting proteins: Q07817 and P00519 |
Pubmed |
SVM Score :0.0 |
| Co precipitations and phosphorylations to mitochondria of c Abl , PKCdelta and Bcl 10 ( L / s ) were induced . ^^^ |
|
| Interacting proteins: Q07817 and P00519 |
Pubmed |
SVM Score :0.0 |
| IL 7 also delayed the decreases in the levels of c Myc , Bcl 2 , and Bcl xL that occur upon loss of 5 Abl kinase activity . ^^^ |
|
| Interacting proteins: Q07817 and P00519 |
Pubmed |
SVM Score :0.0 |
| The tyrosine kinase inhibitor CGP 57148 ( ST 1 571 ) induces apoptosis in BCR ABL positive cells by down regulating BCL 10 . ^^^ We conclude that the inhibition of the BCR ABL kinase by CGP 57148 ( a ) preferentially inhibits the growth of immature leukemic precursor cells , ( b ) efficiently reverts the antiapoptotic effects of BCR ABL by down regulation of BCL 10 , and ( c ) is more effective than the inhibition of the downstream signal transduction pathways of PI 3 kinase , mitogen activated protein / extracellular signal regulated kinase kinase , and Janus activated kinase 2 . . ^^^ |
|
| Interacting proteins: Q07817 and P00519 |
Pubmed |
SVM Score :0.0 |
| The cohort of BCR / ABL expressing cells resistant to apoptosis induced by DM BAD showed only high levels of BCL 2 and BCL 10 ( L ) . ^^^ |
|
| Interacting proteins: Q07817 and P00519 |
Pubmed |
SVM Score :0.0 |
| CGP57148B treatment down regulated antiapoptotic XIAP , cIAP 1 , and Bcl 10 ( L ) , without affecting Bcl 2 , Bax , Apaf 1 , Fas ( CD 95 ) , Fas ligand , Abl , and Bcr Abl levels . ^^^ |
|
| Interacting proteins: Q07817 and P00519 |
Pubmed |
SVM Score :0.0 |
| Bcr / Abl activates transcription of the Bcl 10 gene through STAT 5 . ^^^ We found that the proviability protein Bcl 10 ( L ) , but not Bcl 2 , was induced by both p 210 ( Bcr / Abl ) and STAT 5 1 * 6 . ^^^ Using a Bcl 10 gene promoter construct fused to a luciferase complementary DNA ( cDNA ) , both p 210 ( Bcr / Abl ) and STAT 5 1 * 6 were shown to induce transcription of Bcl 10 . ^^^ The increase in transcription of the Bcl 10 promoter and the increase in Bcl 10 protein , due to p 210 ( Bcr / Abl ) , were blocked by expression of a dominant negative STAT 5 mutant . ^^^ Interestingly , however , STAT 5 1 * 6 required the continued presence of IL 3 to cause a significant increase in Bcl 10 ( L ) protein , whereas p 210 ( Bcr / Abl ) did not need IL 3 . ^^^ |
|
| Interacting proteins: Q07817 and P00519 |
Pubmed |
SVM Score :0.0 |
| Down regulation of bcr abl and bcl 10 ( L ) expression in a leukemia cell line and its doxorubicin resistant variant by topoisomerase 2 inhibitors . ^^^ |
|
| Interacting proteins: Q07817 and P00519 |
Pubmed |
SVM Score :0.0 |
| The results also demonstrate that c Abl mediated phosphorylation of Rad 9 induces binding of Rad 9 to the antiapototic Bcl 10 ( L ) protein . ^^^ |
|
| Interacting proteins: Q07817 and P00519 |
Pubmed |
SVM Score :0.0 |
| Moreover , by modification of anti apoptotic members of the Bcl 2 family ( e . g . upregulation of Bcl 10 ( L ) ) BCR / ABL provides a cytoplasmic ' umbrella ' protecting mitochondria from the ' rain ' of apoptotic signals coming from the damaged DNA in the nucleus , thus preventing release of cytochrome c and activation of caspases . ^^^ |
|
| Interacting proteins: Q07817 and P00519 |
Pubmed |
SVM Score :0.0 |
| K 562 R and LAMA R cells that were markedly resistant to induction of mitochondrial dysfunction ( e . g . loss of mitochondrial membrane potential , Bax translocation , cytochrome c , and apoptosis inducing factor release ) and apoptosis by imatinib mesylate exhibited a pronounced reduction in expression of Bcr / Abl , Bcl 10 ( L ) , and STAT 5 but a striking increase in levels of activated Lyn . ^^^ |
|
| Interacting proteins: Q07817 and P00519 |
Pubmed |
SVM Score :0.0 |
| In this report , we describe induction of plasma cell tumors in littermate control and Bcl 10 ( L ) transgenic mice with a retrovirus expressing 5 Abl and c Myc . ^^^ |
|
| Interacting proteins: Q07817 and P00519 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Cotreatment of Bcr / abl ( + ) cells with minimally toxic concentrations of DMAG and PD 184352 resulted in synergistic induction of mitochondrial injury ( cytochrome c release and Bax conformational change ) , events associated with the pronounced and sustained inactivation of ERK1 / 2 accompanied by down regulation of Bcl 10 ( L ) . ^^^ CONCLUSIONS : A regimen combining the heat shock protein 90 antagonist DMAG and the mitogen activated protein kinase / ERK kinase 1 / 2 inhibitor potently induces apoptosis in Bcr / abl ( + ) cells , including those resistant to imatinib mesylate through various mechanisms including Bcr / abl kinase mutations , through a process that may involve sustained ERK1 / 2 inactivation and Bcl 10 ( L ) down regulation . ^^^ |
|
| Interacting proteins: Q07817 and P00519 |
Pubmed |
SVM Score :0.0 |
| Here we demonstrate that 5 Abl PTK activation is followed by an approximately twofold increase in mRNA level of Bcl XL by 6 h and a corresponding increase in Bcl XL protein level by 24 h . ^^^ Bcl xL RNA and protein decreased in IL 3 deprived cells in the absence of 5 Abl PTK activity . ^^^ Exposure of cells with 5 Abl PTK active to the PKC inhbitor calphostin C ( 125 ng / ml ) prevented the increase in Bcl xL protein and resulted in apoptosis . ^^^ The data suggest that suppression of apoptosis by 5 Abl PTK in the absence of IL 3 is associated with PKC signalling and the upregulation of Bcl xL in IC . ^^^ |
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| Interacting proteins: Q07817 and P00519 |
Pubmed |
SVM Score :0.0 |
| Bcl 2 independent Bcr Abl mediated resistance to apoptosis : protection is correlated with up regulation of Bcl xL . ^^^ Interestingly , wild type and mutant Bcr Abl induced in HL 60 cells a dramatic down regulation of Bcl 2 and increased the levels of Bcl xL . ^^^ Bcl xL , however , seems to participate in part in Bcr Abl mediated resistance to apoptosis in HL 60 cells . . ^^^ |
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| Interacting proteins: Q07817 and P00519 |
Pubmed |
SVM Score :0.0 |
| DP cells ; that 5 Abl TK activation , probably via upregulation of Bcl XL , prevents loss of Psim and blocks the release of cytochrome c from mitochondria ; and that neither of these mitochondrial events is sufficient for commitment to apoptosis . . ^^^ |
|
| Interacting proteins: Q07817 and P00519 |
Pubmed |
SVM Score :0.0 |
| The anti apoptotic properties of BCR / ABL can be partly explained by an increase in the expression of Pim 1 and Bcl XL , as ectopic expression of these STAT 5 target genes imparts both cytokine independent survival and partial gamma radiation resistance . ^^^ |
|
| Interacting proteins: Q07817 and P00519 |
Pubmed |
SVM Score :0.0 |
| This phenomenon correlated with accumulation of cells in the G2 / M phase of cell cycle ; transient downregulation of NFkappaB DNA binding activity ; downregulation of Bcl xL ; activation of caspase 3 , induction of apoptosis ; inhibition of expression and phosphorylation of Bcr / Abl . ^^^ |
|
| Interacting proteins: Q07817 and P00519 |
Pubmed |
SVM Score :0.0 |
| Bcl xL mRNA was elevated in three of five 5 Abl transformed MEF clones . ^^^ The data suggest that increases in cell survival associated with Bcl xL and increases in cell growth associated with c Myc facilitate the transformation process dependent on constitutive mitogenic signaling by 5 Abl . . ^^^ |
|