| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.63967365 |
| In ER stressed cells , but not in normal cells , Bcl xL was co immunoprecipitated with Bim , a pro apoptotic member of the Bcl 2 family , suggesting that Bcl xL sequesters Bim , thereby inhibiting the apoptotic signaling . 0.63967365^^^ |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.64110166 |
| Substitution of the conserved leucine residue in the BH 3 domain of BimEL for alanine ( M 1 ) inhibits the interaction of BimEL with Bcl XL but does not abolish the ability of BimEL to induce Bax conformational change and apoptosis . 0.64110166^^^ |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Bim ( L ) , although unable to activate Bax , can directly inhibit Bcl 2 or Bcl 10 ( L ) . ^^^ |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| PS 341 activated the BH 3 only proteins Bik and Bim and down regulated Bcl 2 and Bcl xL mRNA and protein expression . ^^^ |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Significantly , Bcl xL and Bcl w , the two closest homologues of Bcl 2 , also bind to Bim and inhibit its activity , but more distant viral homologues , adenovirus E1B19K and Epstein Barr virus BHRF 1 , can do neither . ^^^ |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Deletion of BH 4 rendered Bcl 2 ( and Bcl xL ) inactive but did not impair either Bcl 2 homodimerization or ability to bind to Bax or five other pro apoptotic relatives ( Bak , Bad , Bik , Bid or Bim ) . ^^^ |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Endogenous Apaf 1 also failed to coimmunoprecipitate with endogenous Bcl 2 or Bcl 10 ( L ) , or with two proapoptotic relatives ( Bax and Bim ) . ^^^ |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Western blot analysis revealed that the content of Bcl 10 ( L ) ( but not of Bcl 2 , BAX , Bad , and Bim ) significantly decreased in thymocytes after CLP . ^^^ |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| The expression of Bcl 2 family proteins ( Bcl 2 , Bcl 10 , Bax , Bak and Bim ) in human lymphocytes . ^^^ We investigated the expression of Bcl 2 , Bcl 10 , Bax , Bak and Bim in human lymphocytes using flow cytometry . ^^^ |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| TCR ligation upregulated Bim expression and promoted interaction of Bim with Bcl XL , inhibiting its survival function . ^^^ |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Enforced expression of PIM 2 ( 34 kDa ) kinase does not appear to regulate expression of BCL 2 , BCL xL , BIM , or BAX proteins . ^^^ |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| The crystal structure of mouse Bcl 10 ( L ) bound to a long helical fragment of Bim indicates that the structure of Bim is very different from proteins with a Bcl 2 like fold and may leave the BH 3 region of Bim constitutively exposed . ^^^ Based on the structural homology between Bcl 10 ( L ) and Bax , we predicted that binding of Bim to Bax would require displacement of the Bax penultimate alpha helix . ^^^ The structure of a Bcl xL / Bim fragment complex : implications for Bim function . ^^^ |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| This led , in turn , to the activation of the BCL 2 homology 3 domain only proteins BIM and BAD and down regulation of the anti apoptotic multi BCL homology domain protein BCL xL . ^^^ |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| However , IGF 1 does not regulate Bim or anti apoptotic Bcl xL protein expression levels , which suggests that IGF 1 neuroprotection is not through regulation of their expression . ^^^ |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| At the molecular level , IGF IR deficiency in fetal brown adipocytes altered the balance of the expression of several proapoptotic ( Bcl xS and Bim ) and antiapoptotic ( Bcl 2 and Bcl xL ) members of the Bcl 2 family . ^^^ |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| One prominent feature was the increased ratio between the levels of expression of pro apoptotic ( BIM ) and anti apoptotic ( Bcl XL and Bcl W ) genes . ^^^ |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| To understand which JNK mediated pathway may be involved , a number of JNK target proteins were examined , including the transcription factor , c Jun , and the apoptotic regulatory proteins Bcl 10 ( L ) and Bim . ^^^ |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Prolonged insulin treatment ( 24 hours ) increased expression of antiapoptotic genes ( Bcl xL ) , downregulated proapoptotic genes ( Bim and nuclear Foxo 1 ) , and decreased caspase 3 activity in wild type hepatocytes but not in IRS 2 ( / ) cells . ^^^ |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Proapoptotic Bcl 2 family member Bim is involved in the control of mast cell survival and is induced together with Bcl XL upon IgE receptor activation . ^^^ The prosurvival protein Bcl XL and the proapoptotic Bim were both induced upon FcvarepsilonRI activation . ^^^ |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Down regulation of normal human T cell blast activation : roles of APO2L / TRAIL , FasL , and c FLIP , Bim , or Bcl 10 isoform expression . ^^^ We have observed for the first time that the higher sensitivity of normal human T cell blasts to apoptosis and activation induced cell death ( AICD ) as compared with naive T cells correlates with the increased expression of Bcl 10 short ( Bcl xS ) and Bim . ^^^ |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Specifically , we observe that Abeta significantly reduces expression of antiapoptotic Bcl w and Bcl 10 ( L ) , mildly affects expression of bim , Bcl 2 , and bax , but does not alter expression of bak , bad , bik , bid , or BNIP3 . ^^^ |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| In the current study , we demonstrated that in normal tonsil B cells the three major Bim isoforms are strongly associated with the anti apoptotic Bcl 2 family members Mcl 1 , Bcl 2 and Bcl 10 ( L ) . ^^^ Endogenous association of Bim BH 3 only protein with Mcl 1 , Bcl xL and Bcl 2 on mitochondria in human B cells . ^^^ |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Indeed , bortezomib induced increases of Bik and / or Bim in multiple cell lines but not notably of two other BH 3 only proteins ( Puma and Bid ) nor other family members ( Bax , Bak , Bcl 2 , and Bcl xL ) . ^^^ |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| In both cases , Oc survival was accompanied by analogous rises in the mRNA ratios for anti apoptotic Bcl xL and Bfl 1 relative to pro apoptotic Bax , and by marked protein suppression of the critical pro apoptotic signal Bim . ^^^ |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Distinct mechanisms of neuronal apoptosis are triggered by antagonism of Bcl 2 / Bcl 10 ( L ) versus induction of the BH 3 only protein Bim . ^^^ To determine if this is the principal function of Bim in CGNs , we contrasted Bim mediated apoptosis to neuronal death induced by HA 14 1 , a BH 3 domain mimetic that antagonizes Bcl 2 and Bcl 10 ( L ) . ^^^ These data show that antagonism of Bcl 2 / Bcl 10 ( L ) function elicits oxidative stress dependent CGN apoptosis that is mechanistically distinct from Bim mediated cell death . ^^^ These results further indicate that , although Bcl 2 / Bcl 10 ( L ) antagonism is sufficient to induce neuronal apoptosis , Bim likely promotes neuronal death by interacting with additional proteins besides Bcl 2 / Bcl 10 ( L ) . . ^^^ |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| The enhanced TRAIL effect after pretreatment with HDAC inhibitors was consistent with the upregulation of the proapoptotic Bcl 2 family members ( Bim , Bak , Bax , Noxa , and PUMA ) , the downregulation of the anti apoptotic members of the Bcl 2 family ( Bcl 2 and Bcl 10 ( L ) ) , and IAPs . ^^^ |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| We also find that TCR cross linking on thymocytes induces an increase in the proportion of Bcl 10 ( L ) bound to Bim at late time points . ^^^ Our results favor a model in which strong TCR signals regulate the apoptotic activity of Bim by phosphorylation and subsequent changes in binding to Bcl 10 ( L ) in immature thymocytes . . ^^^ |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| This was associated with up regulation of the pro death Bak and Bim , as well as with attenuation of the levels of Her 2 and XIAP , survivin , Bcl 2 , and Bcl 10 ( L ) proteins . ^^^ |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Some defects in the function of PKCtheta ( / ) T cells ( poor survival and reduced Bcl 2 and Bcl 10 ( L ) expression , CTL activity , and IFN gamma expression ) were partially or fully restored by coculture with wild type T cells or by addition of exogenous IL 2 , whereas others ( increased Bim ( EL ) expression and TNF alpha production ) were not . ^^^ |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| TLR mediated protection also failed to correlate with increased expression of Bcl 10 or decreased expression of pro apoptotic Bim . ^^^ |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Coimmunoprecipitation experiments were designed to study Bcl XL / Bim heterodimerization , and Western blots to study cytochrome c release . ^^^ Results from coimmunoprecipitation experiments indicate that the effect of ( ) gossypol is mediated , at least , in part via disrupting the heterodimerization of Bcl XL with Bim in BxPC 3 pancreatic cancer cells . ( ) Gossypol completely disrupts Bcl XL / Bim heterodimerization with no change in the total Bcl XL or Bim protein , indicating that ( ) gossypol treatment does not affect the levels of Bcl XL and Bim proteins . ^^^ |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| In addition , treatment with TGF beta induced binding of Bim , a proapoptotic Bcl 2 homology domain 3 ( BH 3 ) only protein , to Bcl 10 ( L ) , which is dependent on the activation of Smad , and reduction in the expression of Bim by RNA interference decreased the sensitivity to TGF beta induced apoptosis . ^^^ |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| HDAC inhibitors enhance the apoptosis inducing potential of TRAIL in leukemia cells ( HL 60 , Jurkat , K 562 , and U 937 ) through multiple mechanisms ; up regulation of DR 4 , DR 5 , Bak , Bax , Bim , Noxa and PUMA , down regulation of IAPs , Mcl 1 , Bcl 2 , Bcl XL and cFLIP , release of mitochondrial proteins ( cytochrome c , Smac / DIABLO and Omi / Htr2 ) to the cytosol , induction of p21WAF1 / CIP1 and p27KIP1 , activation of caspase 3 and cleavage of poly ( ADP ribose ) polymerase ( PARP ) . ^^^ |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| DBPT induced the phosphorylation of Bcl xL and Bim , and induced apoptosis , as evidenced by cleavage of caspase and poly ( ADP ribose ) polymerase . ^^^ |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| In addition , inhibition of PI 3 kinase did not alter levels of Bax , Bcl 2 , Bcl 10 ( L ) or Bim proteins in mitochondria but caused translocation of the pro apoptotic protein Bad to mitochondria . ^^^ |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| The pro apoptotic Bcl 2 family proteins , Bak , Bax , and Bim have been shown to be required for disruption of mitochondria and intrinsic cell death of self reactive B cells whereas the anti apoptotic Bcl 2 , Bcl xL , and Mcl 1 can prevent cell death by interfering with the action of Bax and Bak . ^^^ |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Levels of proapoptotic factors ( bim and bax ) increased and levels of antiapoptotic factors ( bcl 2 and bcl xL ) decreased in a dose dependent manner . ^^^ |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Cotreatment with LBH 589 and AMN 107 exerted synergistic apoptotic effects with more attenuation of p STAT 5 , p ERK1 / 2 , c Myc , and Bcl 10 ( L ) and increases in p 27 and Bim levels . ^^^ |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| IL 21 stimulation also results in down regulation of antiapoptotic proteins such as Bcl 10 ( L ) and up regulation of proapoptotic proteins like Bim . ^^^ |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemistry was employed to examine the expression of the antiapoptotic proteins Bcl 2 and Bcl XL and the proapoptotic proteins Bad , Bak , Bax , Bid , Bim , and p 53 in 21 cases of gastric cancer . ^^^ |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| There was no evidence that calpain cleaved Bcl 2 family member proteins that regulate mitochondrial membrane permeability including Bcl 2 , Bcl xl , Bad , Bak , Bid , or Bim . ^^^ |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Its three factions of interacting proteins include the BH 3 only proteins ( e . g . , Bim , Puma , Bad , Noxa ) , which transduce diverse cytotoxic signals to the mammalian pro survival proteins ( Bcl 2 , Bcl 10 ( L ) , Bcl w , Mcl 1 , A 1 ) , whereas Bax and Bak , when freed from pro survival constraint , provoke the mitochondrial permeabilization that triggers apoptosis . ^^^ |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| In the current study , we demonstrate that melphalan induces a drastic downregulation of Mcl 1L , Bcl 10 ( L ) and BimEL in human melphalan sensitive myeloma cells while the most potent proapoptotic isoforms , BimL and S , are affected to a lesser extent . ^^^ |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Induction of both proapoptotic ( Bcl2l11 , Casp 6 ) and antiapoptotic ( Bcl 10 ) genes , besides suppression of p 21 , suggest complex cell death / protection related mechanisms operating early on . ^^^ |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| In the yeast cell assay , BOD interacts with diverse antiapoptotic Bcl 2 proteins [ Mcl 1 , Bcl 2 , Bcl xL , Bcl w , Bfl 1 , and Epstein Barr virus ( EBV ) BHRF 1 ] but not with different proapoptotic Bcl 2 proteins ( BAD , Bak , Bok , and Bax ) . ^^^ |
|
| Interacting proteins: O43521 and Q07817 |
Pubmed |
SVM Score :0.0 |
| In the yeast two hybrid system , Mcl 1 binds to the hypophosphorylated mutant of BAD and interacts preferentially with different proapoptotic ( Bax , Bak , Bok , Bik , and BOD ) compared with antiapoptotic Bcl 2 family members ( Bcl 2 , Bcl xL , Bcl w , Bfl 1 , CED 9 , and BHRF 1 ) . ^^^ |
|