Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
Examples of prominent CARD proteins are caspase 9 and Apaf 1 , which are involved in the intrinsic death pathway ; BCL 10 and CARD 11 , which mediate antigen receptor induced NF kappaB activation ; and receptor interacting protein ( RIP ) like interacting caspase like apoptosis regulatory protein kinase ( RICK ) and the nucleotide binding oligomerization domain ( NOD ) proteins , which induce NF kappaB activation in response to intracellular bacterial peptidoglycan . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
Bcl 2 expression is markedly increased in TGF beta 1 treated pre B cells , whereas cellular FLICE like inhibitory protein long ( c FLIPL ) , Bcl XL , Bax , and Bad expression remains unchanged . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
Characterization of the resulting clones for inhibitors of TRAIL induced death ( ITIDs ) led to the isolation of c FLIP ( S ) , Bax inhibitor 1 , and Bcl XL as candidate suppressors of TRAIL signaling . ^^^ We have demonstrated that c FLIP ( S ) and Bcl XL are sufficient when overexpressed to convey resistance to TRAIL treatment in previously sensitive cell lines . ^^^ Furthermore both c FLIP ( S ) and Bcl XL protected against overexpression of the TRAIL receptors DR 4 and KILLER / DR5 . ^^^ When c FLIP ( S ) and Bcl XL were overexpressed together in SW 480 and HCT 116 , an additive inhibitory effect was observed after TRAIL treatment suggesting that these two molecules function in the same pathway in the cell lines tested . ^^^ Surprisingly , we have found that the serine / threonine protein kinase Akt , which is an upstream regulator of both c FLIP ( S ) and Bcl XL , is not sufficient when overexpressed to protect against TRAIL in the cell lines tested . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
We now demonstrate that active caspase 8 is initially generated at the DISC of both MCF 7 Fas Vec and MCF 7 Fas Bcl 10 ( L ) cells and that the early steps of CD 95 signaling such as caspase 8 dependent cleavage of DISC bound c FLIP ( L ) , caspase 8 dependent clustering , and internalization of CD 95 , as well as processing of pro caspase 8 bound to mitochondria are very similar in both transfectants . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
Both cell lines express almost the same levels of FADD , RIP , c FLIP , FAP 1 , Bax , Bcl 2 and Bcl XL . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
Bcl 2 , Bcl xL and c FLIP ( L ) potentially regulate the susceptibility of human peripheral blood monocyte derived dendritic cells to cell death at different developmental stages . ^^^ Antigen ( Ag ) specific and nonspecific cognate interaction with T cells failed to cause cell death of iDCs and mDCs . iDCs constitutively expressed transcripts and intracellular products of Bcl 2 and Bcl xL , but not cellular FLICE inhibitory protein ( long ( c FLIP ( L ) ) , while the increased expressions of Bcl 2 , Bcl xL and c FLIP ( L ) were observed in mDCs . ^^^ These results suggest that the selective expressions of Bcl 2 , Bcl xL and c FLIP ( L ) may be involved in the difference in the susceptibility to cell death between iDCs and mDCs . . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
The ability of CpG ODN to protect T cells from these forms of death was associated with the up regulation of antiapoptotic gene products including c FLIP , bcl xL , and , to some extent , bcl 2 . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
Their survival was associated with expression of antiapoptotic cellular FLICE inhibitory protein ( c FLIP ) , Bcl 10 ( L ) , and Bcl 2 . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
Antiapoptotic proteins of the Bcl 2 family such as Bcl 2 and Bcl 10 ( L ) are also expressed but , in contrast to c FLIP , c IAP , and 10 chromosome linked IAP , do not appear to be tightly regulated by the presence of the parasite . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
Antiapoptotic function of NF kappaB in T lymphocytes is influenced by their differentiation status : roles of Fas , c FLIP , and Bcl xL . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
Activation of caspases 9 and 3 plays a role in 2A3 antibody induced apoptosis , since inhibitors specific for these caspases and overexpression of the anti apoptotic protein Bcl 10 ( L ) , but not c FLIP , inhibit 2A3 antibody triggered endothelial cell death . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
DHMEQ inhibition of NF kappaB triggers activation of caspases 8 and 9 , as well as G0 / G1 cell cycle arrest accompanied by downregulation of antiapoptotic genes Bcl XL and c FLIP and cell cycle progression gene cyclins D 1 and D 2 . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
Bcl xl , in contrast to bcl 2 and c FLIP , is strongly upregulated after viral infection and represents an essential NFkappaB dependent survival factor against TRAIL mediated apoptosis . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
Expression of c FLIP , Fas associated phosphatase 1 , FADD , Bcl 2 , Bcl 10 ( L ) , and Bcl 10 ( S ) was determined by Western blot analysis . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
Inhibition of T cell death by 4 1BB ligation and up regulation of c FLIP ( short ) and Bcl 10 ( L ) were abolished by blocking the phosphatidylinositol 3 kinase or the AKT / protein kinase B , which also mediate CD 28 induced inhibition of activation induced cell death . ^^^ Costimulation by CD137 / 4 1BB inhibits T cell apoptosis and induces Bcl xL and c FLIP ( short ) via phosphatidylinositol 3 kinase and AKT / protein kinase B . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
Moreover , substantial evidence that H / RS cells have defective cell cycle and apoptosis regulation has been provided by studies showing that these cells are characterized , in a large proportion of cases , by alterations of the p 53 , Rb and p 27 tumor suppressor pathways , overexpression of cyclins involved in the G1 / S and G2 / M transition such as cyclins E , D 2 , D 3 , A and B 1 , overexpression of cyclin dependent kinases such as CDK 1 , 2 and 6 and overexpression of anti apoptotic proteins such as c FLIP , bcl xl , c IAP 2 , 10 linked I4P and survivin . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
RESULTS : Multiple survival factor genes , including cellular inhibitor of apoptosis protein ( c IAP 1 ) , c IAP 2 , TNF receptor associated factor 1 ( TRAF 1 ) , TRAF 2 , B cell leukemia / lymphoma 2 ( Bcl 2 ) , Bcl 10 , A 1 , and cellular Fas associated death domain ( FADD ) like interleukin 1beta converting enzyme like inhibitory protein ( c FLIP ) , were expressed in basal conditions in both cultured RPE cells and RPE cells in situ , whereas survivin was expressed only by cultured cells . ^^^ TRAF 1 , c FLIP , and to a lesser extent c IAP 2 protein levels were increased by TNF alpha in a time dependent manner , whereas c IAP 1 , survivin , Bcl 10 ( L ) , and TRAF 2 protein levels were not influenced by TNF alpha treatment at any time point tested . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
Differential effect of anti apoptotic genes Bcl xL and c FLIP on sensitivity of MCF 7 breast cancer cells to paclitaxel and docetaxel . ^^^ In the present study , we tested the sensitivity of MCF 7 breast cancer cells overexpressing anti apoptotic genes TRAF 1 , c FLIP , Bcl xL , clAP 2 or Mn SOD to paclitaxel and docetaxel . ^^^ Cell cycle analysis and carboxyfluorescein FLICA assay were employed to determine whether defects in the cell cycle arrest or apoptotic pathway are responsible for the resistance of cells overexpressing Bcl xL or c FLIP . ^^^ Caspase 8 and 9 activities were measured in cells overexpressing Bcl xL or c FLIP exposed to docetaxel and paclitaxel using fluorescent substrate cleavage assay . ^^^ CONCLUSION : Because c FLIP inhibits the extrinsic pathway of cell death whereas Bcl xL inhibits the intrinsic pathway of cell death , these results suggest that overexpression of anti apoptotic genes that inhibit either the extrinsic or intrinsic cell death pathways can reduce sensitivity of cancer cells to paclitaxel , whereas anti apoptotic genes that inhibit only the intrinsic pathway reduce sensitivity to docetaxel . . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
BAY 11 7082 and curcumin induced cell death was associated with downregulation of Bcl xL , cyclin D 1 , XIAP and c FLIP , followed by caspase 8 , poly ( ADP ribose ) polymerase cleavage and activation . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
The activation of NF kappaB inhibits apoptosis via a mechanism involving upregulation of various antiapoptotic genes , such as cellular FLICE inhibitory protein ( c FLIP ) , Bcl xL , A1 / Bfl 1 , and 10 chromosome liked inhibitor of apoptosis ( XIAP ) . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
In addition , loss of endogenous Siva 1 also resulted in the enhanced expression of NF kappaB responsive anti apoptotic genes such as Bcl xL and c FLIP . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
Apoptosis induced by DHMEQ was accompanied by downregulation of NF kappaB dependent antiapoptotic genes : c IAP , Bfl 1 , Bcl 10 ( L ) and c FLIP . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
The up regulated expression of Bcl 2 , Bcl xL and the cellular FLICE inhibitory protein ( c FLIP ) in fluoxetine treated NSCs was detected by real time RT PCR . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
A large amount of Adv Casp 8 ( MOI of 50 ) induced apoptosis significantly in HCC cells and resulted in downregulation of c FLIP ( in SK Hep 1 , HLE , and HepG 2 cells ) , XIAP , survivin , and Bcl xL ( in HLE cells ) and dynamic release of cytochrome c and Smac from the mitochondria into the cytosol . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
The anti apoptotic proteins like FLAME 1 , Bcl 2 and Bcl xL are believed to be such CHX sensitive inhibitors in various types of cancer cells . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
Importantly , up regulation of Gadd 45 beta by CD 40 precedes Fas induced caspase activation , as well as up regulation of other NF kappa B controlled inhibitors of apoptosis such as Bcl xL and c FLIPL . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
Finally , we have also shown that T cell blasts surviving PHA induced AICD are memory CD44high cells with increased c FLIPS and Bcl xL expression . . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
As a result , we identified four genes ( Bcl 2 , Bcl XL , cIAP 2 , and CFLAR ) whose expression was four or more times higher in HCT116 / hRFI cells than in HCT116 / LacZ cells , and found that Bcl 2 and the ratio of Bcl 2 / Bax or Bcl 2 / Bak were upregulated when HCT116 / hRFI cells were treated with 5 FU . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
The elevated apoptosis was not due to alterations in expression or to mutations in Bcl 2 , Bcl 10 ( L ) , or Flip , nor could the spontaneous apoptosis be prevented by blocking Fas , suggesting that it was independent of Fas signaling . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
We tested an unselected panel of 11 melanoma cell lines for sensitivity to CD 95 and the corresponding expression of CD 95 , CD95L , bcl 2 , bcl 10 , bcl xS , bax and FLIP proteins . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
Several endogenous or viral inhibitors of apoptosis , including Bcl 2 , Bcl xL , FLIP , p 35 , and CrmA , have been shown to be cleaved by caspases during apoptosis . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
Proximate mediators for Fas resistance include the known anti apoptotic gene products Bcl xL and FLIP ( but not Btk ) , and a novel anti apoptotic gene that encodes Fas apoptosis inhibitory molecule ( FAIM ) . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
Terminal effectors of B cell Fas resistance include the known anti apoptotic gene products , Bcl xL and FLIP , and a novel anti apoptotic gene that encodes FAIM ( Fas Apoptosis Inhibitory Molecule ) . faim was identified by differential display and exists in two alternatively spliced forms ; faim S is broadly expressed , but faim L expression is tissue specific . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
Recently developed antisense oligonucleotides with the ability to inhibit the expression of anti apoptotic proteins , including Bcl 2 , Bcl xL , FLIP and surviving , have been shown to facilitate tumor cell apoptosis and sensitize tumor cells to cytotoxic treatments . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
In contrast to BCL 2 , BCL 10 ( L ) , 10 linked inhibitor of apoptosis protein ( XIAP ) and FLICE inhibitory protein ( FLIP ) , the levels of the cyclin dependent kinase ( CDK ) inhibitor , p21Waf / Cip1 , rapidly decreased in response to CHX . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
In contrast , APRIL does not regulate the expression levels of the antiapoptotic proteins FLICE inhibitory protein ( FLIP ) , Bcl 2 or Bcl 10 ( L ) . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
In this condition , Th 2 type cytokines upregulate the anti apoptotic molecules FLIP and Bcl 10 ( L ) and protect thyrocytes from apoptosis . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
Exogenous mrIL 2 restored MRL apoptosis to the level of FVB / N ; in addition , expression of procaspase 3 , and FLIP ( L ) , Bcl 10 ( L ) and CD 25 was normalized . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
Indeed , DC activation effectively inhibited DC apoptosis , which was predominantly accompanied by the upregulation of Bcl 10 ( L ) and to a lesser extent Bcl 2 , while Bax and FLICE inhibitory protein ( FLIP ) remained unchanged . ^^^ We conclude that under serum free conditions , Bcl 10 ( L ) rather than FLIP plays the main role in protection against DC apoptosis . . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
Cellular expression of Bcl 2 , Bcl 10 ( L ) , Bax or Bad in MS patients was independent of the expression of other apoptotic regulatory molecules , such as Fas receptor protein or FLIP . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
In contrast , the expression of several known anti apoptotic proteins ( FLIP , XIAP , Bcl 10 ( L ) ) was not altered during myogenesis . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
The administration of agonistic anti Fas antibody ( CH 11 ) or cycloheximide alone did not induce apoptosis , whereas the co administration of CH 11 with cycloheximide induced apoptosis in WI 38 cells , in which caspase 8 and 3 , but not 9 , were activated , and 10 chromosome linked inhibitor of apoptosis ( ILP ) and FLICE like inhibitor protein ( FLIP ( L ) ) , but not bcl xL and bcl 2 , were remarkably down regulated . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
A survey of molecules involved in TRAIL or Bax mediated apoptotic pathways showed no significant change in expression of death receptors , death decoy receptors ; FLIP ; Bcl 2 ; Bcl xS ; Bax ; Bak ; XIAP or caspase 2 , 7 , 8 , or 9 in either DLD1 / Bax R or DLD1 / TRAIL R cells . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
Antiapoptotic , NF kappa B responsive transcripts include two gene products previously implicated in mediating anti Ig induced Fas resistance , Bcl 10 ( L ) and FLIP . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
Bcl 10 ( L ) and FLIP were identified after DNA sequencing analysis of cDNA rescued from TRAIL resistant clones . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
FLIP and BCL XL expression may reduce sensitivity of cancer cells to combination therapies . . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
Peripheral immune cells were investigated for apoptosis and for the expression of apoptosis regulatory genes CD 95 , CD 95 ligand , FLIP , Bcl 2 , Bcl 10 ( L ) , Bag 1 , and caspase 3 by quantitative real time PCR . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
LPS stimulation induced the expression of Fas , caspase 8 , cellular FLIP Bfl 1 / A1 , and Bcl 10 , but not FasL , TNFR p 55 , Bak , Bax , and Bad at the transcriptional level . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
Sequential up regulation of FLIP ( FLICE like inhibitory protein ) , but not Bcl 2 , Bcl 10 ( L ) or inhibitors of apoptosis protein ( IAPs ) , was observed in resistant cells but not in parental cells . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
These changes in the Fas Fas ligand pathway and Bcl 2 mitochondrial apoptosis regulation are enhanced by complete suppression of antiapoptotic FADD like IL 1beta converting enzyme inhibitory protein ( FLIP ) ( from 30 . 5 to 0 . 0 % , P < 0 . 01 ) and Bcl xL ( from 22 . 5 to 0 . 1 % , P = 0 . 03 ) expression among these cells from the earliest days after gene transfer . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
To explain this intriguing differential sensitivity between unstimulated CD34+ cells versus those stimulated by Epo + KL , we examined the expression of apoptosis regulating genes ( FLIP , BCL 2 , BCL XL , BAD and BAX ) in these cells . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
Interestingly , death effector domain containing proteins such as MC 159 , E 8 , K 13 , and cellular FLIP , but not the apoptosis inhibitors Bcl xL , p 35 , and XIAP , potently suppressed programmed necrosis . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
Interestingly , we found that the elevated expression of FLIP , Bcl 10 ( L ) and IAP in parallel with a downregulation of FADD and Bid was common for the resistant cell lines . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
On the other hand , expression levels of the other anti apoptotic factors , such as FLICE inhibitory protein ( FLIP ) , Bcl 2 and Bcl XL , which are associated with the Fas mediated apoptotic signal pathway , did not change after LY 294002 treatment . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
Apoptosis related proteins were also expressed , including FLIP , bclx , Apaf 1 and XIAP , but expression levels differed among the three cell lines . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
Stat 3 C upregulated expression of FLICE inhibitor protein ( FLIP ) , Bcl xL , and Bcl 2 , and accordingly downregulated activities of FLICE and caspase 3 that were redox independent . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
TNF induced expression of the NF kappaB regulated gene products cyclin D 1 , COX 2 , MMP 9 , survivin , IAP 1 , IAP 2 , Bcl 10 ( L ) , Bfl 1 / A1 , TRAF 1 , and FLIP in wild type mouse embryonic fibroblasts but not in GSK 3beta ( / ) cells , and this correlated with potentiation of TNF induced apoptosis as indicated by cell viability , annexin 5 staining , and caspase activation . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
Immunohistochemical evaluation included members of the NF kappaB ( p 50 , p 65 , p 52 , c Rel , Rel B ) and the IkappaB ( IkappaBalpha , IkappaBbeta , IkappaBepsilon , Bcl 3 ) families , as well as putative targets of NF kappaB such as Flip , Bcl xL , Cyclin D 1 , and oestrogen and progesterone receptors . ^^^ Immunostaining for putative targets of NF kappaB was as follows : Bcl xL , 76 . 2 % ( p = 0 . 001 ) ; Flip 43 . 0 % ; Cyclin D 1 , 64 . 79 % . p 65 immunostaining correlated with increased immunoreaction for steroid hormone receptors . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
Bcl 10 ( L ) expression also up regulated FLIP , a caspase 8 inhibitor . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
NF kappaB regulated gene products such as Cyclin D 1 , c Myc , COX 2 , MMP 9 , ICAM 1 , MDR 1 , Survivin , XIAP , IAP 1 , IAP 2 , FLIP , Bcl 2 , Bcl xL , and Bfl 1 / A1 were all down regulated by evodiamine . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
FLIP expression also upregulated Bcl 10 ( L ) , an antiapoptotic protein . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
Consequently , ACA suppressed the expression of TNF induced NF kappaB regulated proliferative ( e . g . , cyclin D 1 and c Myc ) , antiapoptotic ( survivin , inhibitor of apoptosis protein 1 ( IAP 1 ) , IAP 2 , 10 chromosome linked IAP , Bcl 2 , Bcl 10 ( L ) , Bfl 1 / A1 , and FLIP ) , and metastatic ( cyclooxygenase 2 , ICAM 1 , vascular endothelial growth factor , and matrix metalloprotease 9 ) gene products . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
Immunoblot analysis for major antiapoptotic proteins showed considerable up regulation of the short form of cellular FLIP ( cFLIP ) and Bcl 10 ( L ) in BD activated T cells , while levels of Bcl 2 , caspase 3 , and caspase 8 in activated T cells from patients with BD were comparable with those in activated T cells from normal donors . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
NF kappaB regulated gene products , such as cyclin D 1 , COX 2 , MMP 9 , ICAM 1 , c Myc , survivin , IAP 1 , IAP 2 , XIAP , Bcl 2 , Bcl xL , Bfl 1 / A1 , TRAF 1 and FLIP , were all downregulated by zerumbone . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
Intriguingly , and despite of interfering with a cellular machinery in charge of controlling the half life of the vast majority of cellular proteins , bortezomib did not promote a generalized disruption of melanoma associated survival factors ( including NF kappaB , Bcl 2 , Bcl 10 ( L ) , XIAP , TRAF 2 , or FLIP ) . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
Subsequent studies showed that combined treatment with bortezomib or MG 132 resulted in an increase of death receptor ( DR ) 5 and Bik at protein levels but had no effects on protein levels of DR 4 , Bax , Bak , Bcl 2 , Bcl XL or Flice inhibitory protein ( FLIP ) . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
Apoptosis by I3C involves downregulation antiapoptotic gene products , including Bcl 2 , Bcl xL , survivin , inhibitor of apoptosis protein ( IAP ) , 10 chromosome linked IAP ( XIAP ) , and Fas associated death domain protein like interleukin 1 beta converting enzyme inhibitory protein ( FLIP ) ; upregulation of proapoptotic protein Bax ; release of micochondrial cytochrome C ; and activation of caspase 9 and caspase 3 . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
Treatment with arsenic trioxide ( ATO ; 2 200 microM ) inhibited NF kappaB activity in normal marrow , primary MDS , and ML 1 cells , even in the presence of exogenous TNF alpha ( 20 ng / mL ) , and down regulated NF kappaB dependent antiapoptotic proteins , B cell leukemia XL ( Bcl XL ) , Bcl 2 , 10 linked inhibitor of apoptosis ( XIAP ) , and Fas associated death domain ( FADD ) like interleukin 1beta converting enzyme ( FLICE ) inhibitory protein ( FLIP ) , leading to apoptosis . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
Although TG 2 / thymocytes exposed to anti Fas antibodies die at the same rate as wild type mice , TG 2 / hepatocytes show increased sensitivity toward anti Fas treatment both in vivo and in vitro , with no change in their cell surface expression of Fas , levels of FLIP ( L ) ( FLICE inhibitory protein ) , or the rate of 1 kappaBalpha degradation , but a decrease in the Bcl xL expression . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
Expression of Smad 7 and Bcl 10 ( L ) , but not viral FLIP , was shown to prevent TGF beta induced apoptosis , indicating an exclusive requirement of the activation of Smad signaling pathway and mitochondrial dysfunction followed by activation of caspase 9 . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
These observations corresponded with the down regulation of the expression of anti apoptotic ( IAP 1 , IAP 2 , 10 chromosome linked IAP , Bcl 2 , Bcl 10 ( L ) , TRAF 1 , FLIP , and survivin ) , proliferative ( cyclin D 1 , cyclooxygenase 2 , and c Myc ) , and angiogenic ( ICAM 1 , matrix metalloproteinase 9 , and vascular endothelial growth factor ) gene products . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
The authors tried to determine the responsible molecules ; however , expression of TRAIL receptors ; pro caspase 3 / 8 / 9 ; Fas associated death domain protein ( FADD ) ; tumor necrosis factor receptor 1 associated death domain protein ( TRADD ) ; silencer of death domain ( SODD ) ; FLICE inhibitory protein ( FLIP ) ; and Bcl 2 , Bcl xL , and Bax in FLS was not modulated by IFN gamma . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
TSA reduced FLICE inhibitory protein ( FLIP ) expression but not Bcl 2 , Bcl XL , and Fas expression , indicating that the synergistic effect may be through downregulation of FLIP . ^^^
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15519 and Q07817	Pubmed	SVM Score :0.0
NA