| Interacting proteins: O15304 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Siva 1 binds to and inhibits BCL 10 ( L ) mediated protection against UV radiation induced apoptosis . ^^^ The fact that Siva 1 is partly localized to mitochondria despite the absence of any mitochondrial targeting signal , it harbors a 20 aa long putative amphipathic helical structure that is absent in Siva 2 , and that its expression is restricted to double positive ( CD 3 ( + ) , CD 4 ( + ) , CD 8 ( + ) ) thymocytes like BCL 10 ( L ) , prompted us to test for a potential interaction between Siva 1 and BCL 10 ( L ) . ^^^ Here , we show that Siva 1 binds to and inhibits BCL 10 ( L ) mediated protection against UV radiation induced apoptosis . ^^^ Indeed , the unique amphipathic helical region ( SAH ) present in Siva 1 is required for its binding to BCL 10 ( L ) and sensitizing cells to UV radiation . ^^^ Natural complexes of Siva 1 / BCL 10 ( L ) are detected in HUT 78 and murine thymocyte , suggesting a potential role for Siva 1 in regulating T cell homeostasis . . ^^^ |
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| Interacting proteins: O15304 and Q07817 |
Pubmed |
SVM Score :0.0 |
| The Siva 1 putative amphipathic helical region ( SAH ) is sufficient to bind to BCL XL and sensitize cells to UV radiation induced apoptosis . ^^^ Despite the fact that Siva 1 does not belong to the BCL 2 family , it specifically interacts with the anti apoptotic protein BCL XL and sensitizes MCF 7 breast cancer cells expressing BCL XL to UV radiation induced apoptosis . ^^^ In this paper we demonstrate that the SAH region in Siva 1 is sufficient to specifically interact with the anti apoptotic members of the BCL 2 family such as BCL XL and BCL 2 but not its apoptotic member BAX . ^^^ |
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| Interacting proteins: O15304 and Q07817 |
Pubmed |
SVM Score :0.0 |
| A potential method of overcoming such resistance is to use a potentiator that is capable of neutralizing the antiapoptotic effects of BCL 2 / BCL XL , such as Siva 1 . ^^^ |
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| Interacting proteins: O15304 and Q07817 |
Pubmed |
SVM Score :0.0 |
| In addition , loss of endogenous Siva 1 also resulted in the enhanced expression of NF kappaB responsive anti apoptotic genes such as Bcl xL and c FLIP . ^^^ |
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| Interacting proteins: O15304 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
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