| Interacting proteins: Q07812 and Q9Y371 |
Pubmed |
SVM Score :0.77745366 |
| Bax interacting factor 1 ( Bif 1 ) interacts with both Bax and Bak that are essential for the intrinsic pathway of apoptosis , and enhances apoptosis . 0.77745366^^^ |
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| Interacting proteins: Q07812 and Q9Y371 |
Pubmed |
SVM Score :0.0 |
| A new cDNA encoding a protein of 362 amino acids designated SH3GLB1 , for SH 3 domain GRB 2 like endophilin B 1 , was identified in a yeast two hybrid screen devoted to the identification of new partners interacting with the apoptosis inducer Bax . ^^^ SH3GLB1 and SH3GLB2 do not significantly influence the onset and time course of Bax mediated apoptosis in HeLa or 293T cells . . ^^^ |
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| Interacting proteins: Q07812 and Q9Y371 |
Pubmed |
SVM Score :0.0 |
| Loss of Bif 1 suppresses Bax / Bak conformational change and mitochondrial apoptosis . ^^^ Bif 1 , a member of the endophilin B protein family , interacts with Bax and promotes interleukin 3 withdrawal induced Bax conformational change and apoptosis when overexpressed in FL5 . 12 cells . ^^^ Here , we provide evidence that Bif 1 plays a regulatory role in apoptotic activation of not only Bax but also Bak and appears to be involved in suppression of tumorigenesis . ^^^ Inhibition of endogenous Bif 1 expression in HeLa cells by RNA interference abrogated the conformational change of Bax and Bak , cytochrome c release , and caspase 3 activation induced by various intrinsic death signals . ^^^ While Bif 1 did not directly interact with Bak , it heterodimerized with Bax on mitochondria in intact cells , and this interaction was enhanced by apoptosis induction and preceded the Bax conformational change . ^^^ |
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