| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| The former include p 53 , Bid , Noxa , PUMA , Bax , TNF , TRAIL , Fas / FasL , PITSLRE , interferons , and c KIT / SCF . ^^^ |
|
| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| Treatment of CLL cells with fludarabine induced only the proapoptotic genes Bax and Puma in a p 53 dependent manner . ^^^ |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| Veratridine induced transcription of the pro apoptotic p 53 target gene PUMA , but not of bax or pig 3 . ^^^ |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| It was shown that some of the pro apoptotic family members , such as Bax , Noxa or PUMA , are transcriptional targets of p 53 . ^^^ |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| The p 53 target genes tested can be divided into a group showing high promoter occupancy in vivo ( p 21 , MDM 2 , and PUMA ) and a group giving substantially weaker or background p 53 binding ( bax , AIP 1 , and PIG 3 ) . ^^^ |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| Among them are Bcl 2 family members , Noxa , PUMA , and Bax . ^^^ The Bax protein belongs to the multidomain Bcl 2 family , while Noxa and PUMA are BH 3 domain only proteins . ^^^ |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| Proapoptotic activity of p 53 was shown to involve several genes like Bax , Noxa and Puma , which may function in the release of cytochrome c from the mitochondria . ^^^ |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| We transfected these cells with luciferase reporter plasmids containing promoter sequence of p 53 target genes ( p21waf1 , BAX , MDM 2 , p53AIP1 or PUMA ) . ^^^ |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| The PUMA protein interacts with Bcl 10 ( L ) and promotes mitochondrial translocation and multimerization of Bax . ^^^ Accordingly , genetic disruption of BAX makes cells resistant to the apoptosis resulting from PUMA expression . ^^^ |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| Analysis of this database yielded 23 proteins with a pro apoptotic BH 3 domain and three with anti apoptotic BIR2 / BIR3 domains , including well known p 53 targets : Bax , Puma , Noxa and survivin . ^^^ |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| Bax conformational change is a crucial step for PUMA mediated apoptosis in human leukemia . ^^^ Overexpression of PUMA was accompanied by an increased Bax expression , Bax conformational change , and translocation to mitochondria . ^^^ A PUMA BH 3 peptide can induce Bax conformational change , cytochrome c release , and reduction in the mitochondrial membrane potential ( DeltaPsi ( m ) ) in isolated K 562 mitochondria and can be inhibited by Bcl XL . ^^^ The homo dimer of Bax / Bax was also weakly shown after mitochondria were treated with PUMA BH 3 peptide but may not be lethal for PUMA induced apoptosis in K 562 cells . ^^^ Our results suggest that PUMA induced Bax conformational change and Bax translocation to mitochondria can be separate events and the conformational change in Bax is crucial for PUMA induced mitochondrial dysfunction . . ^^^ |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| The absence of Bax or PUMA strongly inhibited both p 53 induced apoptosis and ROS increase , indicating an important role these p 53 targets affecting mitochondrial function genes in p 53 mediated ROS accumulation . ^^^ |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| We found that p 73 induced apoptosis is mediated by PUMA ( p 53 up regulated modulator of apoptosis ) induction , which , in turn , causes Bax mitochondrial translocation and cytochrome c release . ^^^ Induces apoptosis via PUMA transactivation and Bax mitochondrial translocation . p 73 , an important developmental gene , shares a high sequence homology with p 53 and induces both G ( 1 ) cell cycle arrest and apoptosis . ^^^ The ability of p 73 to directly transactivate PUMA and the direct effect of PUMA on Bax conformation and mitochondrial relocalization suggest a molecular link between p 73 and the mitochondrial apoptotic pathway . ^^^ Our data therefore indicate that PUMA mediated Bax mitochondrial translocation , rather than its direct transactivation , correlates with cell death . ^^^ The DeltaNp 73 isoforms seem therefore to act as dominant negatives , repressing the PUMA / Bax system and , thus , finely tuning p 73 induced apoptosis . ^^^ |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| We found that Ad / p53 induced the expression of the proapoptotic genes PUMA , Bak , Bax , and Fas in a cell type and time dependent manner . ^^^ |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| We demonstrated that bortezomib induced p 53 , and activated its downstream genes p 21 , PUMA and Bax in a p 53 dependent fashion . ^^^ |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| Expression of other proapoptotic genes , including BAX , BAD , BID , and PUMA , was unaffected by treatment with 5 aza deoxycytidine . ^^^ |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| Perp , a tetraspan protein localizing to the plasma membrane , rather than to mitochondria , is a novel type of p 53 effector that may stimulate apoptosis through a different mechanism from the BH 3 containing proteins Noxa , Puma , and Bax . . ^^^ |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| By binding to p 63 and p 73 in vitro and in vivo , ASPP 1 and ASPP 2 stimulate the transactivation function of p 63 and p 73 on the promoters of Bax , PIG 3 , and PUMA but not mdm 2 or p 21 ( WAF 1 / CIP1 ) . ^^^ |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| This cell death involves neither subcellular redistribution of p 53 nor transcriptional regulation of p 53 target genes such as Bax , Ras , Puma or Bcl 2 . ^^^ |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| Macroarrays led to the identification of several Env elicited , p 53 dependent proapoptotic transcripts , in particular Puma , a proapoptotic `` BH 3 only ' ' protein from the Bcl 2 family known to activate Bax / Bak . ^^^ Down modulation of Puma by antisense oligonucleotides , as well as RNA interference of Bax and Bak , prevented Env induced apoptosis . ^^^ |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| Thus , at 8 hours following radiation treatment , the p 21 and puma promoter sites were characterized by relative increases in chromatin precipitation , while the bax promoter site was not . ^^^ |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| Moreover , PUMA knockout HCT 116 cells were resistant to MDA induced Bax conformational change and apoptosis . ^^^ However , ectopic expression of the p 53 point mutation L22Q / W23S , but not the proline rich domain deletion mutants 83 393 and DeltaProAE , could also sensitize p 53 knockout HCT 116 cells to MDA induced Bax activation and apoptosis , although all mutants failed to restore PUMA expression . ^^^ Together , these findings suggest that p 53 acts upstream of Bax to promote MDA mediated cell death in a proline rich domain dependent manner through both transcription dependent ( by up regulating PUMA expression ) and independent mechanisms in human colon cancer HCT 116 cells . . ^^^ |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| Activation of PUMA is associated with the activation and clustering of the pro apoptotic Bcl 2 family member Bax and the loss of cytochrome C from the mitochondria . . ^^^ |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| The first alpha helix of Bax plays a necessary role in its ligand induced activation by the BH 3 only proteins Bid and PUMA . ^^^ We report that the first alpha helix ( Halpha 1 ) of Bax specifically interacts with the BH 3 domains of Bid and PUMA but not with that of Bad . ^^^ Inhibition of this interaction , by a peptide comprising Halpha 1 or by a mutation in this helix , prevents ligand induced activation of Bax by Bid , PUMA , or their BH 3 peptides . ^^^ Halpha 1 mutated Bax , which can mediate death induced by Bad or its BH 3 peptide , does not mediate that induced by Bid , PUMA , or their BH 3 peptides . ^^^ Thus , a specific interaction between Bax Halpha 1 and their BH 3 domains allows Bid and PUMA to function as `` death agonists ' ' of Bax , whereas Bad recruits Bax activity through a distinct pathway . . ^^^ |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| The molecular mechanism through which p 73 induces apoptosis involves ( 1 ) expression and changes in subcellular localization of scotin , producing an endoplasmic reticulum ( ER ) stress ; and ( 2 ) transactivation of PUMA and Bax , thus determining cell fate . ^^^ |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| We now report that C . trachomatis infection leads to degradation of Bik , Puma , and Bim , three upstream proapoptotic BH 3 only proteins of the Bcl 2 family that can transmit death signals to mitochondria by inhibiting the Bcl 2 antiapoptotic proteins and / or activating the Bcl 2 proapoptotic members , such as Bax and Bak . ^^^ |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| Farnesyltransferase inhibitor BMS 214662 induces apoptosis in myeloma cells through PUMA up regulation , Bax and Bak activation , and Mcl 1 elimination . ^^^ BMS 214662 treatment increased levels of the BH 3 only protein PUMA ; induced proapoptotic conformational changes of Bax and Bak ; reduced Mcl 1 levels ; caused mitochondrial transmembrane potential loss ; induced cytochrome c release , caspase activation , apoptosis inducing factor ( AIF ) nuclear translocation , and phosphatidylserine exposure ; and allowed the development of apoptotic morphology . ^^^ These results suggest that apoptosis triggered by BMS 214662 is initiated by a PUMA / Bax / Bak / Mcl 1 dependent mechanism . ^^^ |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| PUMA ( P 53 up regulated modulator of apoptosis ) , a mitochondrial proapoptotic BH 3 only protein , induces rapid apoptosis through a Bax and mitochondria dependent pathway . ^^^ PUMA ( P 53 up regulated modulator of apoptosis ) , a mitochondrial proapoptotic BH 3 only protein , induces rapid apoptosis through a Bax and mitochondria dependent pathway . ^^^ PUMA , we showed that ( a ) PUMA induced apoptosis is dose and time dependent ; ( b ) PUMA induced apoptosis is directly associated with ROS generation ; ( c ) diphenyleneiodonium chloride , a ROS blocker , or BAX inhibiting peptide , a suppressor of BAX translocation , decreased ROS generation and apoptosis in DLD 1 . ^^^ Our findings indicate that PUMA induces apoptosis , in part , through the BAX dependent generation of superoxide and hydrogen peroxide . ^^^ |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| Indeed , bortezomib induced increases of Bik and / or Bim in multiple cell lines but not notably of two other BH 3 only proteins ( Puma and Bid ) nor other family members ( Bax , Bak , Bcl 2 , and Bcl xL ) . ^^^ |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| DeltaNp 73 downregulation was accompanied by increased levels of the pro apoptotic BH 3 family member PUMA at the mRNA and protein level , and by conformational activation of BAX which translocated to mitochondria . ^^^ |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| Western blot analysis was used to analyze the expression of p 53 , p 53 phospho Ser 15 , p 21 , Bax , PUMA , and Bcl 10 ( L ) . ^^^ |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| Second , TAp 73 induces the mitochondrial pathway by directly transactivating both Bax and the BH 3 only protein PUMA promoters . ^^^ |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| Target genes induced by p 53 in neurons include those encoding the pro apoptotic proteins Bax and the BH 3 only proteins PUMA and Noxa . ^^^ |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| Transcriptional upregulation of PUMA modulates endoplasmic reticulum calcium pool depletion induced apoptosis via Bax activation . ^^^ Recent evidence implicates Bax to be an important mediator of PUMA activated apoptotic signals . ^^^ We now present evidence that TG upregulates PUMA expression and that although Bax deficient cells exhibit resistance to TG , Bax deficiency does not attenuate TG upregulation of PUMA expression . ^^^ Thus , our results demonstrate that TG engages PUMA and Bax for full transduction of apoptotic signals and both PUMA and Bax appear to exist in the same TG activated apoptotic pathway in which PUMA may reside upstream of Bax . . ^^^ |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| In the characterization of the IP 10 induced apoptotic pathway , we found that overexpression of IP 10 upregulated p 53 and resulted in altered expression of p 53 responsive genes such as the p21Cip1 , p27kip1 , NF kappaB , Bax , and PUMA genes and the mitochondrial translocation of Bax . ^^^ |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| In adriamycin treated BALB / 3T3 cells , the down shift in temperature from 37 degrees C to 32 degrees C increased the Bcl xL protein level and decreased the mRNA level of Puma and mitochondrial translocation of Bax , suppressing caspase 9 mediated apoptosis . ^^^ |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| The enhanced TRAIL effect after pretreatment with HDAC inhibitors was consistent with the upregulation of the proapoptotic Bcl 2 family members ( Bim , Bak , Bax , Noxa , and PUMA ) , the downregulation of the anti apoptotic members of the Bcl 2 family ( Bcl 2 and Bcl 10 ( L ) ) , and IAPs . ^^^ |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| Irradiated cells became senescent , although irradiation triggered a functional p 53 response and induced expression of p 21 , Bax , and Puma . ^^^ |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| In these cells , Cr ( 6 ) induced apoptosis is mediated by p 53 upregulation of p 53 upregulated modulator of apoptosis ( PUMA ) , BAX translocation to mitochondria , cytochrome c release , and caspase 3 activation . ^^^ In primary human bronchial epithelial cells expressing functional p 53 , Cr ( 6 ) induced expression of PUMA and Noxa , which promote apoptosis through BAX . ^^^ |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| The efficacy of chemotherapeutic agents on tumor cells has been shown to be modulated by tumor suppressor gene p 53 and its target genes such as Bcl 2 family members ( Bax , Noxa , and PUMA ) . ^^^ |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| Pharmacologic modulation of GSK 3beta markedly impaired p 53 dependent transactivation of targets including p 21 and Puma but promoted p 53 dependent conformational activation of Bax , resulting in cytochrome c release , loss of mitochondrial membrane potential , and caspase 9 processing . ^^^ We further show that the induction of apoptosis is through a direct mitochondrial pathway that requires Bax but not Puma . ^^^ |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| These sensitive cells showed an increased Bax and PUMA transcription , altered mitochondrial membrane potential , followed by the release of cytochrome c , and cleaved caspase 9 and caspase 3 . ^^^ |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| HDAC inhibitors enhance the apoptosis inducing potential of TRAIL in leukemia cells ( HL 60 , Jurkat , K 562 , and U 937 ) through multiple mechanisms ; up regulation of DR 4 , DR 5 , Bak , Bax , Bim , Noxa and PUMA , down regulation of IAPs , Mcl 1 , Bcl 2 , Bcl XL and cFLIP , release of mitochondrial proteins ( cytochrome c , Smac / DIABLO and Omi / Htr2 ) to the cytosol , induction of p21WAF1 / CIP1 and p27KIP1 , activation of caspase 3 and cleavage of poly ( ADP ribose ) polymerase ( PARP ) . ^^^ |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| Surprisingly , the effect of TSA on the proapoptotic Bcl 2 proteins was mixed , the two isoforms of PUMA ( alpha , beta ) , Noxa , Bax were downregulated , while Bim was upregulated . ^^^ |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| Nutlin 3 stabilized p 53 and induced p 53 target genes , including MDM 2 , p 21 ( CIP 1 ) , PUMA , BAX , PIG 3 , and WIG 1 . ^^^ |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| We found that 3 ng / ml of BMP 4 is sufficient to induce the expression of proapoptotic proteins , puma and bax , in a p 53 dependent mechanism , and facilitate Ca ( 2+ ) release from the ER to the cytosol , resulting in the activation of caspase 12 and ER dysfunction . ^^^ |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| This is linked to the activation and translocation of Bax to the mitochondrial membrane , cytochrome c release into the cytosol , and activation of caspase 3 , in a PUMA dependent manner . ^^^ Thus , interference with the p53 / PUMA / Bax cascade is crucial for the antiapoptotic function of the viral E 6 oncogene in HPV positive cancer cells . . ^^^ |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| Hence Noxa , Puma and Bim could potentially link p 53 to Bax . ^^^ Despite the powerful pro apoptotic effects of overexpressed Puma in Bax expressing neurons , Bax nullizygous neurons were resistant to Puma induced death . ^^^ Therefore , Puma provides the critical link between p 53 and Bax , and is both necessary and sufficient to mediate DNA damage induced apoptosis of sympathetic neurons . . ^^^ |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| HCT 116 lines , wherein the downstream p53 / p73 targets Bax and PUMA ( p 53 up regulated modulator of apoptosis ) were deleted , were less sensitive to T ara C and gemcitabine . ^^^ |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| PUMA Dissociates Bax and Bcl 10 ( L ) to induce apoptosis in colon cancer cells . ^^^ PUMA interacts with anti apoptotic Bcl 2 and Bcl 10 ( L ) and is dependent on Bax to induce apoptosis . ^^^ In this study , we investigated how the interactions of PUMA with the antiapoptotic proteins coordinate with Bax to initiate apoptosis in HCT 116 colon cancer cells . ^^^ Mutant Bcl 10 ( L ) that can not interact with Bax was unable to protect cells from PUMA mediated apoptosis . ^^^ Furthermore , Bax was found to be dissociated preferentially from Bcl 10 ( L ) in HCT 116 cells but not in the PUMA knockout cells , in response to PUMA induction and adriamycin treatment . ^^^ |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| To test the role of Bad , Bim , and other proapoptotic Bcl 2 family members in IL 3 withdrawal induced apoptosis , we generated IL 3 dependent cell lines from mice lacking the genes for Bad , Bim , Puma , both Bad and Bim , and both Bax and Bak . ^^^ |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| Our data also suggest that PUMA and Bax are required for p 53 dependent apoptosis in manner that is independent of p 53 transcriptional activity . . ^^^ |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| The apoptotic death of putaminal neurons and glia in a patient with hereditary ferritinopathy is studied immunohistochemically with antibodies to p 53 , activated caspase 3 , PUMA , BAX , cytochrome c , and inducible nitric oxide synthase . ^^^ |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| Because p 21 can protect against genotoxic stress by reducing p 53 dependent transcription of the proapoptotic proteins PUMA and Bax , the current study uses genetically modified lines of HCT 116 colon carcinoma cells to investigate whether p 21 mediated protection against hyperoxia involves attenuation of the p 53 apoptotic pathway . ^^^ Genetic ablation of p 21 increased cell death , and loss of Bax or PUMA increased cell survival . ^^^ Unlike damage caused by adriamycin , whereby p 21 sensitivity could be rescued by removal of p 53 , PUMA , or Bax , increased sensitivity of p 21 deficient cells to hyperoxia could not be rescued by additional loss of these genes . ^^^ |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| On incubation with CDDP , levels of positively regulated p 53 transcriptional targets p 21 ( WAF ) , PIG 3 , MDM 2 , Bax , and PUMA increased in p 14 ( ARF ) deficient cells , whereas negatively regulated survivin decreased . ^^^ |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| Its three factions of interacting proteins include the BH 3 only proteins ( e . g . , Bim , Puma , Bad , Noxa ) , which transduce diverse cytotoxic signals to the mammalian pro survival proteins ( Bcl 2 , Bcl 10 ( L ) , Bcl w , Mcl 1 , A 1 ) , whereas Bax and Bak , when freed from pro survival constraint , provoke the mitochondrial permeabilization that triggers apoptosis . ^^^ |
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| Interacting proteins: Q07812 and Q9BXH1 |
Pubmed |
SVM Score :0.0 |
| DSBs are detected by ATM ( ataxia telangiectasia mutated ) and ATR ( ataxia telangiectasia and Rad 3 related ) proteins , which signal downstream to CHK 1 , CHK 2 ( checkpoint kinases ) and p 53 . p 53 induces transcriptional activation of pro apoptotic factors such as FAS , PUMA and BAX . ^^^ There are p 53 backup systems that involve CHK 1 and / or CHK 2 driven E2F1 activation and p 73 upregulation , which in turn transcribes BAX , PUMA and NOXA . ^^^ |
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