| Interacting proteins: Q07812 and Q96BY2 |
Pubmed |
SVM Score :0.0 |
| The tumor suppressor RASSF1A and MAP 1 link death receptor signaling to Bax conformational change and cell death . ^^^ RASSF1A / MAP 1 binding relieved this inhibitory interaction , resulting in MAP 1 association with Bax . ^^^ Deletion of the RASSF1A gene or short hairpin silencing of either RASSF1A or MAP 1 expression blocked MAP 1 / Bax interaction , Bax conformational change and mitochondrial membrane insertion , cytochrome c release , and apoptosis in response to death receptors . ^^^ |
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| Interacting proteins: Q07812 and Q96BY2 |
Pubmed |
SVM Score :0.0 |
| MAP 1 is a mitochondrial effector of Bax . ^^^ We have previously identified modulator of apoptosis 1 ( MAP 1 ) as a Bax associating protein , but its functional relationship with Bax in contributing to apoptosis regulation remains to be established . ^^^ In this study , we show that MAP 1 is a critical mitochondrial effector of Bax . ^^^ MAP 1 is a mitochondria enriched protein that associates with Bax only upon apoptotic induction , which coincides with the release of cytochrome c from mitochondria . ^^^ Small interfering RNAs that diminish MAP 1 levels in mammalian cell lines confer selective inhibition of Bax mediated apoptosis . ^^^ |
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| Interacting proteins: Q07812 and Q96BY2 |
Pubmed |
SVM Score :0.0 |
| The RASSF1A tumor suppressor activates Bax via MOAP 1 . ^^^ We now identify a novel pathway connecting RASSF1A to Bax via the Bax binding protein MOAP 1 . ^^^ RASSF1A can activate Bax via MOAP 1 . ^^^ Moreover , activated K Ras , RASSF1A , and MOAP 1 synergize to induce Bax activation and cell death . ^^^ Analysis of a tumor derived point mutant of RASSF1A showed that the mutant was defective for the MOAP 1 interaction and for Bax activation . ^^^ |
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| Interacting proteins: Q07812 and Q96BY2 |
Pubmed |
SVM Score :0.0 |
| As one of the downstream modulaters of GR activation , Bax can be up regulated and translocated to the mitochondria , where it binds to modulator of apoptosis 1 ( MAP 1 ) , a mitochondrial effector of BAX to cause change Deltapsi . ^^^ |
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