| Interacting proteins: Q07812 and Q13794 |
Pubmed |
SVM Score :0.70893479 |
| Interestingly , the Noxa mitochondrial targeting domain deletion mutant interacted with Bax in a dsRNA dependent manner and redirected Bax away from the mitochondria , thus acting as a dominant negative protein . 0.70893479^^^ |
|
| Interacting proteins: Q07812 and Q13794 |
Pubmed |
SVM Score :0.0 |
| The former include p 53 , Bid , Noxa , PUMA , Bax , TNF , TRAIL , Fas / FasL , PITSLRE , interferons , and c KIT / SCF . ^^^ |
|
| Interacting proteins: Q07812 and Q13794 |
Pubmed |
SVM Score :0.0 |
| Hence Noxa , Puma and Bim could potentially link p 53 to Bax . ^^^ |
|
| Interacting proteins: Q07812 and Q13794 |
Pubmed |
SVM Score :0.0 |
| Cells with an upstream defect , lacking `` multidomain ' ' BAX , BAK demonstrate long term resistance to all BH 3 domain only members , including BAD , BIM , and NOXA . ^^^ |
|
| Interacting proteins: Q07812 and Q13794 |
Pubmed |
SVM Score :0.0 |
| It was shown that some of the pro apoptotic family members , such as Bax , Noxa or PUMA , are transcriptional targets of p 53 . ^^^ |
|
| Interacting proteins: Q07812 and Q13794 |
Pubmed |
SVM Score :0.0 |
| Among them are Bcl 2 family members , Noxa , PUMA , and Bax . ^^^ The Bax protein belongs to the multidomain Bcl 2 family , while Noxa and PUMA are BH 3 domain only proteins . ^^^ |
|
| Interacting proteins: Q07812 and Q13794 |
Pubmed |
SVM Score :0.0 |
| Proapoptotic activity of p 53 was shown to involve several genes like Bax , Noxa and Puma , which may function in the release of cytochrome c from the mitochondria . ^^^ |
|
| Interacting proteins: Q07812 and Q13794 |
Pubmed |
SVM Score :0.0 |
| Recent evidence indicates that some present day prokaryotes release redox proteins that induce apoptosis in mammalian cells through stabilization of the tumour suppressor protein p 53 . p 53 interacts with mitochondria either directly or through activation of the genes for pro apoptotic proteins such as Bax or NOXA or genes that encode redox enzymes responsible for the production of reactive oxygen species ( ROS ) . ^^^ |
|
| Interacting proteins: Q07812 and Q13794 |
Pubmed |
SVM Score :0.0 |
| Noxa and mitochondrial Bax translocation . ^^^ Real time RT PCR analysis reveals a significant induction of RNA expression of Noxa and Bax in p 53 ( + / + ) , but not in p 53 ( / ) MEF . ^^^ Noxa protein expression becomes detectable prior to Bax translocation , and downregulation of endogenous Noxa by RNA interference protects wt MEF against p 53 dependent apoptosis . ^^^ |
|
| Interacting proteins: Q07812 and Q13794 |
Pubmed |
SVM Score :0.0 |
| Mouse embryonic fibroblasts deficient in Noxa [ Noxa ( / ) mouse embryonic fibroblasts ( MEFs ) ] showed notable resistance to oncogene dependent apoptosis in response to DNA damage , which was further increased by introducing an additional null zygosity for Bax . ^^^ |
|
| Interacting proteins: Q07812 and Q13794 |
Pubmed |
SVM Score :0.0 |
| Analysis of this database yielded 23 proteins with a pro apoptotic BH 3 domain and three with anti apoptotic BIR2 / BIR3 domains , including well known p 53 targets : Bax , Puma , Noxa and survivin . ^^^ |
|
| Interacting proteins: Q07812 and Q13794 |
Pubmed |
SVM Score :0.0 |
| In contrast , the induction of proapoptotic Noxa , the activation of Bax , the cytoplasmic release of cytochrome c , as well as a drop of the mitochondrial transmembrane potential Deltapsim are equally observed in wt and apaf 1 ( / ) MEF following DNA damage . ^^^ |
|
| Interacting proteins: Q07812 and Q13794 |
Pubmed |
SVM Score :0.0 |
| In agreement with this lower p 53 response to DNA damage in cells lacking STAT 1 , the induction of p 53 responsive genes , such as Bax , Noxa , and Fas , was reduced in STAT 1 deficient cells . ^^^ |
|
| Interacting proteins: Q07812 and Q13794 |
Pubmed |
SVM Score :0.0 |
| Perp , a tetraspan protein localizing to the plasma membrane , rather than to mitochondria , is a novel type of p 53 effector that may stimulate apoptosis through a different mechanism from the BH 3 containing proteins Noxa , Puma , and Bax . . ^^^ |
|
| Interacting proteins: Q07812 and Q13794 |
Pubmed |
SVM Score :0.0 |
| Furthermore , Notch activation in neural progenitor cells leads to elevated levels of nuclear p 53 and transcriptional upregulation of the target genes Bax and Noxa , and the promotion of apoptotic cell death by Notch activation is completely suppressed by p 53 deficiency . ^^^ |
|
| Interacting proteins: Q07812 and Q13794 |
Pubmed |
SVM Score :0.0 |
| Thus , DNA damage induced apoptosis requires new protein synthesis , accumulation of p 53 tumor suppressor protein , and p 53 dependent induction of BOK and NOXA genes , while a role for BAX in this pathway is not essential . ^^^ |
|
| Interacting proteins: Q07812 and Q13794 |
Pubmed |
SVM Score :0.0 |
| Inhibition of the p 38 MAP kinase pathway rescues by 80 % the initiation of pX mediated apoptosis , whereas subsequent apoptotic events involve both pathways . pX mediated activation of p 38 MAP kinase and JNK pathways is sustained , inducing the transcription of the death receptor family genes encoding Fas / FasL and tumor necrosis factor receptor 1 ( TNFR 1 ) / TNF alpha and the p 53 regulated Bax and Noxa genes . ^^^ In turn , activated Bid , acting with pX induced Bax and Noxa , mediates the mitochondrial release of cytochrome c , resulting in the activation of caspase 9 and apoptosis . ^^^ |
|
| Interacting proteins: Q07812 and Q13794 |
Pubmed |
SVM Score :0.0 |
| Brn 3a transcription factor blocks p 53 mediated activation of proapoptotic target genes Noxa and Bax in vitro and in vivo to determine cell fate . ^^^ Here we show that , like Bax , Brn 3a antagonizes p 53 mediated transcription of another proapoptotic target , Noxa , significantly reducing transactivation of the Noxa promoter by p 53 . ^^^ Moreover , there is a significant elevation of both proapoptotic Bax and Noxa proteins in sensory neuronal tissue taken from Brn 3a / embryos during development , compared with wild type controls . ^^^ |
|
| Interacting proteins: Q07812 and Q13794 |
Pubmed |
SVM Score :0.0 |
| Of note , BIK can cooperate with a weak BH 3 only protein that targets mitochondria , such as NOXA , to activate BAX by a mechanism that is independent of DRP 1 enzyme activity . ^^^ |
|
| Interacting proteins: Q07812 and Q13794 |
Pubmed |
SVM Score :0.0 |
| Target genes induced by p 53 in neurons include those encoding the pro apoptotic proteins Bax and the BH 3 only proteins PUMA and Noxa . ^^^ |
|
| Interacting proteins: Q07812 and Q13794 |
Pubmed |
SVM Score :0.0 |
| ISL treatment was found to result in the upregulation of p 53 , p21 / WAF1 , Fas / APO 1 receptor , Fas ligand , Bax and NOXA , but not in Bad . ^^^ The enhancement of p21 / WAF1 , Fas / APO 1 , Bax and NOXA were decreased in Hep G 2 cells that lack functional p 53 . ^^^ |
|
| Interacting proteins: Q07812 and Q13794 |
Pubmed |
SVM Score :0.0 |
| The enhanced TRAIL effect after pretreatment with HDAC inhibitors was consistent with the upregulation of the proapoptotic Bcl 2 family members ( Bim , Bak , Bax , Noxa , and PUMA ) , the downregulation of the anti apoptotic members of the Bcl 2 family ( Bcl 2 and Bcl 10 ( L ) ) , and IAPs . ^^^ |
|
| Interacting proteins: Q07812 and Q13794 |
Pubmed |
SVM Score :0.0 |
| In primary human bronchial epithelial cells expressing functional p 53 , Cr ( 6 ) induced expression of PUMA and Noxa , which promote apoptosis through BAX . ^^^ |
|
| Interacting proteins: Q07812 and Q13794 |
Pubmed |
SVM Score :0.0 |
| The efficacy of chemotherapeutic agents on tumor cells has been shown to be modulated by tumor suppressor gene p 53 and its target genes such as Bcl 2 family members ( Bax , Noxa , and PUMA ) . ^^^ |
|
| Interacting proteins: Q07812 and Q13794 |
Pubmed |
SVM Score :0.0 |
| HDAC inhibitors enhance the apoptosis inducing potential of TRAIL in leukemia cells ( HL 60 , Jurkat , K 562 , and U 937 ) through multiple mechanisms ; up regulation of DR 4 , DR 5 , Bak , Bax , Bim , Noxa and PUMA , down regulation of IAPs , Mcl 1 , Bcl 2 , Bcl XL and cFLIP , release of mitochondrial proteins ( cytochrome c , Smac / DIABLO and Omi / Htr2 ) to the cytosol , induction of p21WAF1 / CIP1 and p27KIP1 , activation of caspase 3 and cleavage of poly ( ADP ribose ) polymerase ( PARP ) . ^^^ |
|
| Interacting proteins: Q07812 and Q13794 |
Pubmed |
SVM Score :0.0 |
| Surprisingly , the effect of TSA on the proapoptotic Bcl 2 proteins was mixed , the two isoforms of PUMA ( alpha , beta ) , Noxa , Bax were downregulated , while Bim was upregulated . ^^^ |
|
| Interacting proteins: Q07812 and Q13794 |
Pubmed |
SVM Score :0.0 |
| Its three factions of interacting proteins include the BH 3 only proteins ( e . g . , Bim , Puma , Bad , Noxa ) , which transduce diverse cytotoxic signals to the mammalian pro survival proteins ( Bcl 2 , Bcl 10 ( L ) , Bcl w , Mcl 1 , A 1 ) , whereas Bax and Bak , when freed from pro survival constraint , provoke the mitochondrial permeabilization that triggers apoptosis . ^^^ |
|
| Interacting proteins: Q07812 and Q13794 |
Pubmed |
SVM Score :0.0 |
| There are p 53 backup systems that involve CHK 1 and / or CHK 2 driven E2F1 activation and p 73 upregulation , which in turn transcribes BAX , PUMA and NOXA . ^^^ |
|
| Interacting proteins: Q07812 and Q13794 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07812 and Q13794 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07812 and Q13794 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07812 and Q13794 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07812 and Q13794 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07812 and Q13794 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07812 and Q13794 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07812 and Q13794 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07812 and Q13794 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07812 and Q13794 |
Pubmed |
SVM Score :0.0 |
| NA |
|