Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
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Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
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Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
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Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
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Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
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Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
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Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
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Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
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Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
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Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
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Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
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Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
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Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
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Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
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Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
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Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
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Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
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Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
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Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
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Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
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Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
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Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
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Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
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Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
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Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
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Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
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Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
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Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
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Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
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Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
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Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
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Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
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Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
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Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
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Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
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Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
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Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
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Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
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Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
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Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
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Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
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Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
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Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
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Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
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Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
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Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
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Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
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Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
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Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
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Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
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Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
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Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
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Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
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Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
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Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
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Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
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Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
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Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
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Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
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Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :1.1969765
In addition , Mcl 1 was found to interact with Bax , a member of the Bcl 2 family that promotes cell death as a homodimer but that can heterodimerize with Bcl 2 to promote cell viability . 1.1969765^^^ Taken as a whole , these findings provide further parallels between Mcl 1 and Bcl 2 , showing that Mcl 1 can interact with Bax in hematopoietic FDC P 1 cells and can prolong cell viability under a variety of cytotoxic conditions . . 1.1729518^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Bax also heterodimerizes with Bcl xL , Mcl 1 , and A 1 . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Bad selectively dimerized with Bcl xL as well as Bcl 2 , but not with Bax , Bcl xs , Mcl 1 , A 1 , or itself . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
The Bcl 2 family members analyzed were Bcl 2 , Bcl 10 , Bax , Bad , Bak , A 1 , and Mcl 1 . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Bcl 2 , Mcl 1 , and also Bax and Bak , but not p 53 were demonstrable in the tumor cells by immunostaining . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Bcl 2 , Mcl 1 and caspases 2 and 3 protein levels varied widely , whereas Bax expression was comparable among cell lines . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
After Ad5CMVE2F 1 infection , expression of Bax and Bak was unchanged , whereas Mcl 1 levels decreased markedly . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Other proteins important in apoptotic control , Bax , Mcl 1 , and Bcl 10 ( S ) , are unaffected by calcitriol treatment . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
We immunohistochemically examined the protein expression of Bcl 2 , Bcl XL , Mcl 1 , and Bax . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
IL 10 decreased expression of bcl 2 , bcl 10 ( L ) , and mcl 1 but not bax mRNA in monocytes stimulated with GM CSF . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Western blot analysis was performed with anti ERK1 / 2 , Mcl 1 , Bak , Bcl 10 and Bax antibodies . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
All cell lines express high levels of cyclin E , c Myc , Bcl 2 , Bax , Bcl 10 ( L ) , and Mcl 1 . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
The levels of Mcl 1 , Bax , Bid , Akt , c IAP 1 , c IAP 2 , XIAP and c FLIP were compared in all HL 60 lines . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
In the same way , BFA did not alter Bcl 2 , Bax and Mcl 1 expression . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
However , the expression levels of Bcl 2 , Bax , Bak , and Mcl 1 were unchanged . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
While Bcl 2 , Bcl 10 ( L , ) , and Bax were not affected , Mcl 1 was induced by IL 6 in human esophageal carcinoma cells . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
An increase in Bax and a decrease in Mcl 1 proteins were also observed . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
It down regulated the Bcl 2 and Mcl 1 expression , and up regulated Bax protein in a time response manner . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
The expression of MCL 1 and BAX were not different between M Mphi and GM Mphi and were CSF independent . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Interactions of the Bcl 2 protein with itself and other members of the Bcl 2 family , including Bcl 10 L , Bcl 10 S , Mcl 1 , and Bax , were explored with a yeast two hybrid system . ^^^ Bcl 2 also interacted with Bcl 10 L and Mcl 1 and with the dominant inhibitors Bax and Bcl 10 S . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Here , we have investigated the possibility that the three recently identified Bcl 2 homologues , Bax , Bcl 10 , and Mcl 1 , could be involved instead . ^^^ Freshly isolated cells expressed both Bax and Mcl 1 protein , but only low levels of Bcl xL and no detectable Bcl xS , as determined by Western blot analysis . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Immunoblot analysis of cellular expression of Bcl 2 family proteins , Bcl 2 , Bax , Bcl 10 and Mcl 1 , in human peripheral blood and lymphoid tissues . ^^^ Several homologues of the bcl 2 gene , such as bax , bcl 10 or mcl 1 , have recently been identified . ^^^ Like Bcl 2 , both Bcl XL and Mcl 1 appear to function as repressors of apoptotic cell death , whereas Bax facilitates it , indicating possible interactions among them in the control of cellular survival . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Immunohistochemical analysis of bcl 2 , bax , bcl 10 , and mcl 1 expression in prostate cancers . ^^^ Using antibodies specific for the Bcl 2 , Bax , Bcl 10 , and Mcl 1 proteins in combination with immunohistochemical methods , we examined for the first time the expression of these bcl 2 family genes in 64 cases of adenocarcinoma of the prostate , including 10 Gleason grade 2 to 4 tumors , 21 grade 5 to 7 tumors , 17 grade 8 to 10 tumors , 8 lymph node metastases , and 8 bone metastases . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Taken together , these results suggest that expression of Bcl XL is increased in undifferentiated primary colorectal cancers , often with accompanying reciprocal decreases in the anti apoptotic proteins Bcl 2 and Mcl 1 and the pro apoptotic protein Bak , whereas Bax expression is relatively constant . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
The expression of a cell death inducing gene , Bax , was investigated in 52 cases of Hodgkin ' s disease in parallel with Epstein Barr virus and was compared with the immunodetection of other apoptosis regulating proteins , Mcl 1 , Bcl 2 , and Bcl 10 . ^^^ Of 48 ( 89 % ) Bax positive tumors , 43 were found to express apoptosis inhibiting proteins such as Mcl 1 or Bcl 2 . ^^^ With the exception of 1 case , all Bax positive tumors also expressed either Bcl 2 , Bcl 10 , Mcl 1 , or combinations of these anti apoptotic proteins . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Recent work also has revealed the existence of several bcl 2 related genes that also can inhibit ( e . g . , bcl 10 ( L ) and Mcl 1 ) or activate ( e . g . , bax , bcl 10 ( s ) , bag , and bad ) apoptosis in several systems . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
The expression of apoptosis regulating proteins , Bcl 2 , Bax , Mcl 1 , and Bcl 10 , was evaluated by immunohistochemical methods in 39 cases of thyroid carcinomas . ^^^ Normal thyroid tissues showed a consistent expression of Bcl 2 and Mcl 1 whereas Bax and Bcl 10 proteins were essentially absent from most follicular thyroid cells . ^^^ Mcl 1 protein expression was similar to that of Bax in papillary and follicular tumors , but was also frequently detectable in undifferentiated tumors . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
The expression of the apoptosis regulating genes Bcl 2 , Bcl 10 , Bax , Mcl 1 , and p 53 analyzed in 4 cases of human immunodeficiency virus ( HIV ) associated Hodgkin ' s disease , in 36 cases of HIV related non Hodgkin ' s lymphomas ( NHLs ) , and in 109 cases of non HIV related NHLs by using immunohistochemistry . ^^^ For the HIV related NHL samples , 36 , 66 , 88 , 100 , and 94 % of the cases were Bcl 2 , Bcl 10 , Bax , Mcl 1 , and p 53 were found to be expressed in 69 , 65 , 82 , 83 , and 42 % , respectively . ^^^ No significant differences were observed in Bax and Mcl 1 staining between HIV unrelated NHLs of B cell and T cell types . ^^^ Of interest , all cases with a positive expression of Bax were also found to express either Mcl 1 and / or Bcl 2 , suggesting that Mcl 1 and Bcl 2 may counteract the pro apoptosis function of Bax in vivo by protein protein interaction within the tumor cell , as demonstrated previously in vitro . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
We examined the expression of Fas and bcl 2 family gene products , such as Bcl 2 , Bcl 10 , Bax , and Mcl 1 , in human tonsillar B cells . ^^^ The addition of anti Ig did not significantly change Bcl 2 , Bax , and Mcl 1 levels compared to those of B cells activated by CD40L alone . . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Removal of the carboxyl terminal transmembrane ( TM ) domain from Bax [ creating Bax ( deltaTM ) ] prevented targeting to mitochondrial and completely abolished cytotoxic function in yeast cells , suggesting that membrane targeting is crucial for Bax mediated lethality . ^^^ Fusing a TM domain from Mas70p , a yeast mitochondrial outer membrane protein , to Bax ( deltaTM ) restored targeting to mitochondria and cytotoxic function in yeast cells . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
The apoptosis regulating proteins Bcl 2 , Bax , Bcl 10 , Bak , and Mcl 1 were examined by immunohistochemical methods in 48 archival specimens of adenocarcinoma of the stomach , and the results were correlated with tumor histology ( intestinal versus diffuse pattern ) and clinical stage ( early versus late stage disease , ie , stages 1 and 2 versus stage 3 ) . ^^^ Tumor cells containing immunostaining for the anti apoptotic proteins Bcl 2 , Bcl 10 , and Mcl 1 were present in 26 ( 54 % ) , 41 ( 85 % ) , and 36 ( 75 % ) of the 48 cases evaluated , respectively , whereas immunopositivity for the pro apoptotic proteins Bax and Bak was found in 44 ( 92 % ) and 42 ( 88 % ) specimens Comparisons of these immunostaining results with tumor histology revealed statistically significant differences for Bax ( P = 0 . 03 ) , Bcl 10 ( P = 0 . 003 ) , and Mcl 1 ( P = 0 . 005 ) , which were all more frequently immunopositive for tumors with an intestinal than a diffuse histological pattern ( chi 2 analysis ) . ^^^ The immunointensity for the Bcl 2 , Bcl 10 , and Mcl 1 proteins was stronger in tumor cells compared with normal foveolar cells in 7 ( 21 % ) , 15 ( 44 % ) , and 8 ( 2 . 1 % ) of 34 cases , respectively , whereas the immunointensity of the proapoptotic proteins Bax and Bak was reduced compared with normal cells in 8 ( 24 % ) and 24 ( 71 % ) cases . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
This multigene family of cell death regulators includes members which enhance rates of apoptosis , including bcl xs and bax , and those which inhibit apoptosis , including MCL 1 and bcl xL . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Since the discovery of Bcl 2 a decade ago , several other cellular and viral genes encoding homologous proteins have been identified , some of which suppress cell death akin to Bcl 2 ( Bcl XL , Mcl 1 , A1 / Bfl 1 , Nr 13 , Ced 9 , BHRF 1 ) and others which promote apoptosis ( Bax , Bcl Xs , Bak , Bik , Bad ) . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Immunohistochemical analysis of Bcl 2 , Bcl 10 , Mcl 1 , and Bax in tumors of central and peripheral nervous system origin . ^^^ The expression of Bcl 2 , Bcl 10 , Mcl 1 , and Bax was examined by immunohistochemical methods in 93 tumors of nervous system origin , including 49 gliomas ( 30 astrocytomas and 19 glioblastoma multiforme ( GMs ) ) , 16 medulloblastomas ( MBs ) , 19 neuroblastomas ( NBs ; 9 undifferentiated and 10 differentiated ) , and 9 miscellaneous neuroectodermal neoplasms . ^^^ Among the 49 gliomas , immunopositivity ( defined as > or = 10 % ) was observed for Bcl 2 in 45 ( 92 % ) , Bcl 10 in 48 ( 98 % ) , Mcl 1 in 49 ( 100 % ) , and Bax in 48 ( 98 % ) of 49 specimens . ^^^ Of the 16 MBs , immunopositivity was found for Bcl 2 in 4 ( 25 % ) , Bcl 10 in 9 ( 56 % ) , Mcl 1 in 8 ( 50 % ) , and Bax in 16 ( 100 % ) of the cases . ^^^ The intensity of immunostaining was strong for Bcl 2 in only 1 ( 6 % ) specimen , for Bcl 10 in 3 ( 19 % ) , and for Mcl 1 in 2 ( 12 . 5 % ) , in contrast to Bax immunostaining , which was strong in 12 ( 75 % ) tumors . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
These findings demonstrate that cytotoxic DNA damage causes an increase in the expression of MCL 1 along with increases in GADD 45 and BAX and a decrease in BCL 2 . ^^^ Furthermore , while the increase in GADD 45 is seen both in cells that undergo growth arrest and in cells that undergo apoptosis in response to DNA damage , alterations in the profile of expression of BCL 2 family members occur exclusively in cells that undergo the apoptotic response , with some family members increasing through p 53 dependent ( BAX ) and others through p 53 independent ( MCL 1 ) pathways . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
In all LBC tested , radiation induced apoptosis occurs in all phases of the cell cycle and appears not to directly involve changes in the levels of the apoptosis associated proteins bcl 2 , bax and mcl 1 . ^^^ Radiation induced cell death is not cell cycle phase specific , does not involve the regulation of bcl 2 , bax or mcl 1 , but is associated with changes in the phosphorylation state and activation of p34CDC2 kinase . . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Bax / Bak lethality was suppressed by coexpression of Bcl 2 family members that are anti apoptotic in vertebrates , namely Bcl xL , Bcl 2 , Mcl 1 , and A 1 . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
To investigate the dual effects ( proliferation and apoptosis ) of IL 10 on B cells , the expression of a panel of bcl 2 protoncogene family members , bcl 2 , bcl 10 , mcl 1 , and bax , was analyzed when B cells were activated by SAC . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Other proteins , like bcl xL , A 1 or mcl 1 have the same anti apoptotic function , but several molecules of the same family , like bcl xS , bax alpha or bak can trigger the opposite effect . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
HL 60 / Bcl 2 cells displayed a 5 fold increase in Bcl 2 protein compared with empty vector counter parts ( HL 60 / pCEP4 ) but comparable levels of Bax , Mcl 1 , and Bcl xL . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Here we demonstrate that , in addition to the previously identified A 1 , four other members of the Bcl 2 family , Bcl 2 , Mcl 1 , Bcl 10 ( L ) , and Bax , are expressed in endothelial cells . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Levels of Bcl 2 , Mcl 1 , Bcl xL , and Bax each varied over a more than 10 fold range in different pretreatment leukemia specimens . ^^^ Bax levels did not show a twofold decrease in any patient . these results , coupled with recent observations that cells overexpressing Mcl 1 are resistant to a variety of chemotherapeutic agents , raise the possibility that some chemotherapeutic regimens might select for leukemia cells with elevated levels of this particular apoptosis inhibitor . . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
The expression of the Bcl 2 family proteins Bax , Mcl 1 , Bcl 2 , and Bcl xL , was examined in human peripheral blood eosinophils or in umbilical cord blood derived eosinophils . ^^^ Incubation of both eosinophil types for 1 to 3 days in a cytokine deprived medium led to apoptosis , without changes in the expression of Bax , Mcl 1 , Bcl 2 , or Bcl xL . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Immunoblot analysis of primary adenocarcinomas revealed expression of the anti apoptotic proteins Bcl 2 , Bcl 10 ( L ) , Mcl 1 , and BAG 1 , as well as the pro apoptotic proteins Bax , Bak , and CPP 32 , in at least 2 of the 3 tumors examined . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
The expression of several apoptosis regulating proteins , including the Bcl 2 family proteins Bcl 2 , Bcl XL , Mcl 1 , Bax , Bak , and BAD ; the Bcl 2 binding protein BAG 1 ; and the cell death protease Caspase 3 ( CPP 32 ) , was evaluated by immunoblotting using 58 peripheral blood B CLL specimens from previously untreated patients . ^^^ Expression of Bcl 2 , Mcl 1 , BAG 1 , Bax , Bak , and Caspase 3 was commonly found in circulating B CLL cells , whereas the Bcl XL and BAD proteins were not present . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Here we have examined the expression of several proteins involved in the susceptibility to apoptosis in 20 human gliomas , including the BCL 2 family proteins BCL 2 , BCL 10 , BAX and MCL 1 , as well as p 53 and RB . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Positive ( ICE , ICErel 2 , ICErel 3 , Ich 1L , CPP 32 , mch 2 , mch 3 , bcl xS , bax and bak ) and negative ( bcl 2 , bcl xL , MCL 1 and Ich 1S ) regulators of apoptosis were successively examined using a semi quantitative technique of reverse transcription polymerase chain reaction ( RT PCR ) . ^^^ Baseline levels of message were detected for 3 ced 3 ( CPP 32 , Ich 1 and ICE ) and 4 ced 9 homologs ( bcl 10 , MCL 1 , bcl 2 and bax ) in the frontal cortex . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
High grade malignant non Hodgkin ' s lymphomas differ from low grade lymphomas in the extent of apoptosis and their expression of bcl 2 , mcl 1 , bax and p 53 . ^^^ To study the influence of apoptosis regulating proteins bcl 2 , bax , mcl 1 and p 53 on the extent of apoptosis , we also immunostained the samples with antibodies to them . ^^^ The results suggest that apoptosis affecting genes bcl 2 , bax , mcl 1 and p 53 all take part in the regulation of apoptosis in malignant non Hodgkin ' s lymphomas and contribute to a different level of apoptosis between high and low grade non Hodgkin ' s lymphomas . . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Expression of the Bcl 2 family of apoptosis related genes ( bcl 2 , bcl 10 , mcl 1 , and bax ) and the proliferation and apoptosis related genes p 53 and cyclin D 1 were determined in 40 low T stage laryngeal carcinomas and in uvular epithelium from patients without SCC . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Some Bcl 2 related proteins ( Bcl 2 , Bcl xLong , MCl 1 , and Dad 1 ) function as cell death repressors , whereas others ( Bax , Bcl xShort , Bak , and Bad ) facilitate apoptosis . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Immunohistochemical analysis of bcl 2 , bax , mcl 1 , and bcl 10 expression in ovarian surface epithelial tumors . ^^^ The expression of bcl 2 family proteins was investigated in 28 ovarian surface epithelial tumors , including serous and mucinous benign , borderline , and malignant tumors by immunohistochemical staining with antibodies to bcl 2 , bax , bcl 10 , and mcl 1 proteins . ^^^ No difference was seen in immunostaining for bax or mcl 1 when benign , borderline , or malignant serous tumors were compared . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
In this study we have investigated by Western blotting the expression pattern of Bcl 2 and its homologues Bax , Bak , Bcl xL , Bcl xS , Mcl 1 and Bad in 12 distant lymph node metastases from patients who have been treated by different regimes , in nine newly established cell lines of these metastases , in three cell lines obtained from other sources and in primary melanocytic cell lines from three neonatal and two adult subjects . ^^^ Taken together , our data suggest that Bax , Bak , Bad , Bcl xL and Mcl 1 are expressed in addition to Bcl 2 in both normal melanocytes and in cell lines established from melanoma metastases . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Prognostic significance of the bcl 2 apoptotic family of proteins in primary and recurrent cervical cancer . bcl 2 is one of a family of genes that control the apoptotic threshold of a cell . bcl 2 protein and its anti apoptotic homologue , mcl 1 , with the pro apoptotic protein , bax , are thought to function by forming homo and heterotypic dimers that then control the progression to apoptosis . p 53 is also involved as a down regulator of bcl 2 and a promoter of bax . ^^^ To determine the effect of these apoptotic mechanisms , we used immunohistochemistry to determine the prognostic significance of the expression of bcl 2 , mcl 1 , bax and p 53 in primary and recurrent cervical cancer . ^^^ Tissues from 46 patients with primary cervical cancer and 28 women with recurrent carcinoma were stained for bcl 2 , mcl 1 , bax and p 53 . ^^^ Positive staining for p 53 was associated with a survival disadvantage ( p 53 +ve , 4 year survival 38 % vs p 53 ve , 4 year survival 78 % , P = 0 . 02 ) . mcl 1 and bax staining were not useful as prognostic indicators in primary disease . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Bcl 2 family proteins are key regulators of apoptosis and function as cell death antagonists ( e . g . , Bcl 2 , Bcl XL , and Mcl 1 ) or agonists ( e . g . , Bax , Bad , and Bak ) . ^^^ Here we report that among the Bcl 2 family of proteins tested ( Bcl 2 , Bcl XL , Mcl 1 , Bax , Bad , and Bak ) , Bcl XL was unique in that its protein levels were tightly regulated by hemopoietins in both immortal and primary myeloid progenitors . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
We examined the expression of Bax , Bcl 2 , Bcl 10 , and Mcl 1 in human benign nevi , primary MM , and metastatic MM using immunohistochemistry . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
In the yeast cell assay , BOD interacts with diverse antiapoptotic Bcl 2 proteins [ Mcl 1 , Bcl 2 , Bcl xL , Bcl w , Bfl 1 , and Epstein Barr virus ( EBV ) BHRF 1 ] but not with different proapoptotic Bcl 2 proteins ( BAD , Bak , Bok , and Bax ) . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Our BAX deletion constructs and minimal domain constructs indicated that the BH 3 domain was required for BAX homodimerization and heterodimerization with BCL 2 , BCL XL , and MCL 1 . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
OBJECTIVE : To evaluate the relationships among several factors related to proliferation and apoptosis in LAM cells , we employed immunohistochemical methods for the localization of Bcl 2 and Mcl 1 ( inhibitors of apoptosis ) , Bax ( a promoter of apoptosis ) , c Myc ( an apoptosis related oncoprotein ) , proliferating cell nuclear antigen ( an indicator of mitotic activity ) , and nick end labeling ( to identify apoptotic cells ) in lung tissues of 9 patients with LAM . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
The proteins evaluated were p 53 and six members of the Bax / Bcl 2 family : three proapoptotic proteins ( Bax , Bak , and Bcl xS ) and three survival factors ( Bcl 2 , Bcl xL , and Mcl 1 ) . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Expression of the Bcl 2 , Mcl 1 , Bcl 10 , Bax , and Bak proteins was analyzed to determine whether the differences in MCF 7 cell sensitivity to apoptosis could be correlated to the differential expression of these proteins . ^^^ Whereas Bak , Bcl 10 , and Mcl 1 levels were identical between variants , the levels of Bcl 2 were 3 . 5 3 . 8 fold higher and the levels of Bax were 1 . 5 1 . 7 fold lower in the resistant variants ( M and L ) as compared with those of the sensitive variant ( N ) . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Apoptotic index and apoptosis influencing proteins bcl 2 , mcl 1 , bax and caspases 3 , 6 and 8 in pancreatic carcinoma . ^^^ AIMS : To study the expression of bcl 2 , bax and mcl 1 and caspases 3 , 6 and 8 and apoptosis in pancreatic carcinoma . ^^^ METHODS AND RESULTS : Eighty seven pancreatic carcinomas were studied immunohistochemically with antibodies to bcl 2 , mcl 1 , bax and caspases 3 , 6 and 8 . ^^^ Apoptosis was detected by the TUNEL method . bcl 2 and mcl 1 positivity was observed in 13 % and 86 % of the cases , while bax was observed in all of them . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Immunohistochemical analysis of Bcl 2 , Bax , Bcl 10 , and Mcl 1 expression in pancreatic cancers . ^^^ We found that Bcl 2 was expressed in 23 % , Bax in 53 % , Bcl 10 in 90 % , and Mcl 1 in 90 % of the invasive ductal adenocarcinomas . ^^^ In intraductal papillary mucinous adenocarcinomas , the expression rate of Bax was 44 % and those of Bcl XL and Mcl 1 were 88 % ; these values were higher than those for intraductal papillary mucinous adenomas . ^^^ These results suggest that an imbalance between antiapoptosis proteins ( such as Bcl 2 , Bcl XL , and Mcl 1 ) and proapoptotic proteins ( such as Bax and Bcl Xs ) is involved in the distinctive biologic features of adenocarcinomas of the pancreas . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
In a BCL family , BCL 2 was coexpressed in one or two nuclei in the perinuclear space of the multinuclei of MVECs , whereas MCL 1 , BCL XS / L , and BAX were all negative , indicating that the BCL 2 coding gene is expressed only in the corresponding one or two nuclei of the multinuclei . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
There was no correlation between the susceptibility to gemcitabine and the endogenous expression of the B cell lymphoma 2 ( BCL 2 ) family proteins BCL 2 , BCL XL , myeloid cell leukemia 1 ( MCL 1 ) , BCL 2 associated 10 protein ( BAX ) , BCL 2 homologous antagonist / killer ( BAK ) and BCL XS . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
All these events are prevented by p27Kip1 overexpression . p27Kip1 does not modulate Bcl 2 , Bcl 10 ( L ) , Mcl 1 and Bax protein level in leukemic cells but suppresses Mcl 1 expression decrease observed in mock transfected U 937 cells undergoing etoposide induced cell death . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
We used antibodies specific for the human Bcl 2 , Mcl 1 , Bax , Bak and p 53 proteins to examine the expression of these apoptosis regulating genes in 49 archival specimens of patients with radically resected non small cell lung cancer ( NSCLC ) . ^^^ Tumour cells containing immunostaining for the antiapoptotic proteins Bcl 2 and Mcl 1 were present in 31 % and 58 % of the cases evaluated , respectively , whereas immunopositivity for the proapoptotic proteins Bax and Bak was found in 47 % and 58 % of the samples . p 53 immunopositivity was detected in 61 % of the samples . ^^^ The expression of Bcl 2 and p 53 and the expression of Mcl 1 and Bax showed a positive association ( P = 0 . 02 and P = 0 . 06 respectively ) , whereas the expression of Bax was inversely related to p 53 ( P = 0 . 008 ) . ^^^ Our results establish the frequent expression of the Bcl 2 family proteins Bcl 2 , Mcl 1 , Bax and Bak in NSCLC . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
The expression of p 53 and members of the bcl 2 gene family , such as bcl 2 , bax and mcl 1 , were determined immunohistochemically with specific antibodies . ^^^ However , the extent of apoptosis did not correlate with the expression of p 53 , bcl 2 , bax and mcl 1 . ^^^ We conclude that , in the metaplasia dysplasia carcinoma sequence in the lung , the elevation of the AI % is an early event associated with cell proliferation activity , but is independent of the expression of p 53 , bcl 2 , mcl 1 and bax . . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
In addition , the expression of MCL 1 , an antiapoptotic member of the BCL 2 family , is downregulated during Na Sal induced cell death , whereas the expression of BCL 2 , BAX , and BCL XL is unchanged . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Using quantitative Western blotting we have determined the level of expression of BCL 2 , BAX , MCL 1 , and BCL 10 in lymphoblasts from 47 children with ALL ( 33 at presentation only , 4 at relapse only , and 10 at both presentation and on relapse ) . ^^^ BCL 2 , BAX , and MCL 1 were detected in all samples . ^^^ BCL 2 levels and the BCL / BAX and MCL 1 / BAX ratios were found to be significantly higher in B lineage as compared with T lineage disease ( P < . 003 , . 02 , and . 02 , respectively ) . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
The expression of p 53 , Bcl 2 , Mcl 1 , Bax , and Bak was assessed by immunohistochemical analysis . ^^^ RESULTS : Tumor cells containing immunostaining for the antiapoptotic proteins Bcl 2 and Mcl 1 were present in 4 ( 15 % ) and 24 ( 92 % ) of the cases evaluated , respectively , whereas immunopositivity for the proapoptotic proteins Bax and Bak was found in 9 ( 35 % ) and 24 ( 92 % ) of the samples . ^^^ There was a positive correlation between the expression of Bcl 2 and Bax and between Mcl 1 and Bak . ^^^ CONCLUSIONS : Our results establish the frequent expression of the Bcl 2 family proteins Bcl 2 , Mcl 1 , Bax , and Bak in locally advanced head and neck cancer . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
We examined the expression of the bcl 2 family oncoproteins bax , bak , bcl 2 , bcl xL , and mcl 1 in the course of differentiation of human keratinocytes cultured at low ( 0 . 15 mM ) and high ( 1 . 87 mM ) calcium concentrations . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
The expression of Bcl 2 family proteins ( Bcl 2 , Bcl 10 , Bcl XL , Bcl Xs , BAX , BAD , MCL 1 ) and of Interleukin 1 converting enzyme ( ICE ) related proteins ( ICE , CPP 32 , ICH 1 ) was analyzed in acute leukemia cells by flow cytometry . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
The levels of other BCL 2 family members including BAX , BCL 2 , BCL 10 or MCL 1 were not consistently modulated by mutant or wild type p53val135 . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Exposure of undifferentiated U 937 cells to 50 microM etoposide for 6 h , that triggers apoptosis in 80 % cells , activates procaspase 2L , 3 and 8 , induces the mitochondrial release of cytochrome c and decreases Mcl 1 expression without modifying Bcl 2 , Bcl xL and Bax protein levels . ^^^ Exposure of TPA differentiated U 937 cells to 0 . 8 microg / ml cycloheximide for 24 h , that triggers apoptosis in 50 % cells , activates procaspase 2L , 3 and 8 , induces the mitochondrial release of cytochrome c and decreases Bcl xL expression without modifying Bcl 2 , Mcl 1 and Bax protein levels . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
The expression of the pro apoptotic proteins ( Bax , Bak ) and anti apoptotic proteins ( Bcl 2 , Bcl 10 , Mcl 1 ) was studied by immunohistochemistry in 110 invasive ductal breast carcinomas . ^^^ Overall , Bcl 2 , Bcl 10 , Mcl 1 , Bax , Bak , ER , and p 53 were detected in 62 , 75 , 68 , 75 , 60 , 68 and 26 per cent of the cases respectively , but at different levels in each case . ^^^ No correlation was found between the apoptotic index and Bax , Bcl 10 , and Mcl 1 immunostaining results . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Transcript levels of c erbB 2 , p 53 , p 21 , GADD 45 , bax , bcl 10 , mcl 1 , and c fos were also unaffected by EMF exposure . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Examination of expression levels of Bcl 2 protoncogene family members ( Bcl 2 , Bcl 10 ( L ) , Mcl 1 , and Bax ) showed a downregulation of Bcl 10 ( L ) and Mcl 1 after CD 22 ligation . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
In order to test the hypothesis that increased apoptotic activity is connected with neuroendocrine differentiation and low differentiation degree in large cell carcinoma ( LCLC ) and is regulated by bcl 2 family proteins , we analysed the extent of apoptosis and tumor necrosis and their relation to the expression of bcl 2 , bax , bak and mcl 1 in 35 LCLCs , of which 20 were classified as large cell neuroendocrine lung carcinomas ( LCNEC ) and 15 as large cell non neuroendocrine lung carcinomas ( LCNNEC ) . ^^^ The extent and intensity of expression of the bcl 2 , bax , bak and mcl 1 proteins were studied by immunohistochemistry . ^^^ Immunohistochemically detected bax , bcl 2 and bak expression was independent of apoptotic index in both tumor types , while there was a statistically significant positive association between mcl 1 expression and apoptotic index in LCNNEC but not in LCNEC . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
We have found that , in addition to Bcl 2 and Bax , the expression levels of apoptosis inducers ( Bad , Bak ) and inhibitors ( Bcl xL , Mcl 1 ) were highly variable in blasts from 78 children with newly diagnosed acute lymphoblastic leukemia ( ALL ) . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Apoptosis regulating proteins bcl 2 , mcl 1 , and bax were visualized by immunohistochemistry . ^^^ No significant difference was found in the expression of bcl 2 , mcl 1 , and bax in BOOP and in UIP , suggesting that regulation of apoptosis might partly bypass the influence of these proteins . . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Using the GM CSF dependent TF 1 myeloid leukaemia cell line , the authors show that the endogenous levels of BCL 2 and MCL 1 are downregulated upon GM CSF withdrawal , whereas the levels of BCL 10 ( L ) and Bax are unchanged . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Expression of Bcl 2 , Bax , Bcl 10 , and Mcl 1 proteins and of the proliferation marker Ki 67 was evaluated by immunohistochemistry . ^^^ In tumors that had progressed from WHO Grade 3 anaplastic oligodendrogliomas , the authors found significantly more Bcl 10 positive ( P = 0 . 005 ) , Mcl 1 positive ( P = 0 . 002 ) , and Bax positive ( P = 0 . 03 ) cells . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
The differences of expression of BCL 2 , BCL 10 , BAX , and MCL 1 proteins of paired first resection and recurrence glioblastoma specimens were examined . ^^^ RESULTS : In the whole group , we found a significant up regulation of antiapoptotic BCL 2 ( median cumulative score of 15 in the primary , 19 at recurrence ; p < 0 . 0001 in the Wilcoxon test ) , BCLX ( median scores 20 and 25 , respectively , p < 0 . 0001 ) , and MCL 1 ( median scores 11 and 14 , p=0 . 0395 ) , and a significant down regulation of proapoptotic BAX ( median scores 14 and 11 , p < 0 . 0001 ) . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
In the yeast two hybrid system , Mcl 1 binds to the hypophosphorylated mutant of BAD and interacts preferentially with different proapoptotic ( Bax , Bak , Bok , Bik , and BOD ) compared with antiapoptotic Bcl 2 family members ( Bcl 2 , Bcl xL , Bcl w , Bfl 1 , CED 9 , and BHRF 1 ) . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Apoptosis and expression of apoptosis regulating proteins bcl 2 , mcl 1 , bcl 10 , and bax in malignant mesothelioma . ^^^ We investigated apoptosis and the expression of bcl 2 , mcl 1 , bcl 10 , and bax in histological sections from 35 malignant mesotheliomas and 21 metastatic adenocarcinomas . ^^^ Moreover , the expression of bcl 2 , mcl 1 , bcl 10 , and bax were assessed by Western blotting in nonmalignant human mesothelial cells ( Met5A ) and seven malignant cell lines . ^^^ Patients with mesotheliomas showing a high apoptotic index ( > or =0 . 75 % ) had a worse prognosis ( P = 0 . 008 ) . bcl 2 positivity was observed in only seven cases , but bcl 10 , mcl 1 , and bax positivity was seen in all of them . ^^^ In immunoblotting experiments , all mesothelioma cell lines were negative for bcl 2 but positive for bcl 10 , mcl 1 , and bax . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Apoptosis in gallbladder carcinomas and dysplasias , its relation to the expression of caspases 3 , 6 and 8 and apoptosis regulating proteins bcl 2 , mcl 1 and bax . ^^^ In this study we investigated apoptosis and the expression of caspases 3 , 6 and 8 and bcl 2 , mcl 1 and bax in 39 gallbladder carcinomas and 7 epithelial dysplasias . ^^^ In contrast , mcl 1 positivity was found in 34 ( 87 % ) and bax positivity in all cases . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
We examined immunohistochemically 4 apoptosis regulating bcl 2 familial proteins ( bcl 2 , mcl 1 , bcl 10 , and bax ) in the biliary epithelium in 19 cases of primary biliary cirrhosis . ^^^ Bcl 2 and mcl 1 are inhibitors of apoptosis , bcl 10 , probably bcl XL in biliary epithelial cells , an inhibitor , and bax , a promoter of apoptosis . ^^^ Mcl 1 , bcl 10 , and bax were diffusely detectable at the any level of the intrahepatic biliary tree , with a staining pattern that was diffuse and cytoplasmic . ^^^ Expression levels of mcl 1 , bcl 10 , and bax were similarly reduced to that of bcl 2 in these 2 diseases . ^^^ These findings suggest that bax is not important as a proapoptotic factor in the damaged bile ducts and that downregulation of bcl 2 and mcl 1 , and probably that of bcl XL , leads to a decrease in the threshold of apoptosis and increase in the vulnerability to apoptotic stimuli in these bile ducts , followed by the progressive apoptotic loss of interlobular bile ducts , in primary biliary cirrhosis . . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
The BCL 2 family proteins ( BCL 2 , BCL 10 , MCL 1 , and BAX ) and p 53 expression were studied by immunohistochemistry on paraffin slides . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
The authors examined apoptosis and the expression of apoptosis regulating proteins Bcl 2 , Bax , Bak , and Mcl 1 in 21 typical and 10 atypical bronchopulmonary carcinoid tumors . ^^^ METHODS : Thirty one bronchopulmonary carcinoid tumors were examined by using in situ 3 ' end labeling of DNA ( TUNEL ) for apoptosis and immunohistochemical staining methods for Bcl 2 , Bax , Bak , Mcl 1 , p 53 , and Ki 67 in formalin fixed , paraffin embedded tissue specimens . ^^^ No relation between apoptosis and Bcl 2 , Bax , Bak , or Mcl 1 expression was found . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
We observed baseline expression of the anti apoptotic Mcl 1 and pro apoptotic Bax proteins in immunoblots of eosinophil lysates , but not Bcl 10 , Bcl 2 . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
The present study examined the expression of some Bcl 2 family members , including Bcl 2 , Bcl 10 ( L ) , Mcl 1 , and Bax , in response to cytokine stimulation in TF 1 and JYTF 1 cells in which SCF costimulation is differentially required for optimal proliferation . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
RESULTS : Herein , we showed that inhibition of ERK1 / 2 activities caused ( 1 ) a G 1 arrest ; ( 2 ) a down regulation of the expression levels of the anti apoptotic homologs Bcl 2 , Mcl 1 , and Bcl 10 ( L ) without affecting the pro apoptotic levels of Bax and Bak ; ( 3 ) a promotion of caspases 3 , 6 , 8 , and 9 activities ; ( 4 ) a stimulation of PARP cleavage ; and ( 5 ) a programmed cell death by apoptosis . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
METHODS AND RESULTS : By counting apoptotic biliary cells and by immunostaining apoptosis related proteins in normal liver , fatty liver , and those with acute viral hepatitis , chronic viral hepatitis , and hepatitis virus related cirrhosis , it was found that the larger the intrahepatic bile ducts became , the more biliary epithelial cells underwent apoptosis . bcl 2 , an inhibitor of apoptosis , was diffusely expressed in the interlobular bile ducts , but rarely detectable in the large and septal bile ducts . bcl XL and mcl 1 , inhibitors of apoptosis , and bax , a promoter of apoptosis , were diffusely expressed along the intrahepatic biliary tree . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
PURPOSE : The present study was undertaken to investigate the prognostic and predictive relevance of the expression of apoptosis related proteins Bax , Bcl 10 ( L ) , and Mcl 1 in advanced ovarian cancer . ^^^ PATIENTS AND METHODS : Tumor biopsies from 185 consecutive and homogeneously treated patients with stage 3 ovarian cancer were examined immunohistochemically for the expression of Bax , Bcl 10 ( L ) and Mcl 1 proteins . ^^^ RESULTS : Sixty six percent of cancer cases expressed Bax , 62 % Bcl 10 ( L ) , and 53 % Mcl 1 . ^^^ In univariate analysis , Bax expression was associated with improved ( P = . 0004 ) prognosis and Mcl 1 expression with poorer ( P = . 011 ) prognosis . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Since the Bcl 2 family of proteins constitutes a critical checkpoint in apoptosis , acting upstream of the apoptotic machinery , we investigated the expression of six Bcl 2 homologs ( Bcl 2 , Bcl 10 ( L ) , Mcl 1 , Bax , Bak , Bad ) and one non homologous associated molecule ( Bag 1 ) . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
As the balance of bcl 2 genes is a crucial regulatory step in apoptosis , the results suggest that EAT and Bax likely regulate apoptosis in the early stages of differentiation . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Bax kappa , a splice variant of Bax with conserved BH 1 , BH 2 and BH 3 binding domains and a C terminal transmembrane domain ( TM ) , but with an extra 446 bp insert between exons 1 and 2 leading to loss of an N terminal ART domain , was identified from an ischemic rat brain cDNA library . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Bcl 2 and Mcl 1 expression were downregulated in both flavopiridol and fludarabine induced apoptotic cells , but the increase in Bax expression that accompanied fludarabine induced apoptosis was not evident in flavopiridol treated cells . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Using mid gestation human jejunum and colon organotypic cultures , we analyzed the impact of growth factors ( namely insulin ; 10 microg / ml ) and pharmacological compounds that inhibit signal transduction molecules / pathways ( namely tyrosine kinases , Fak , P 13 K / Akt , and MEK / Erk ) on cell survival and Bcl 2 homolog expression ( anti apoptotic : Bcl 2 , Bcl 10 ( L ) , Mcl 1 ; pro apoptotic : Bax , Bak , Bad ) . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
BACKGROUND / AIM : EAT / mcl 1 ( EAT ) , an immediate early gene , functions in a similar way to bcl 2 in neutralising Bax mediated cytotoxicity , suggesting that EAT is a blocker of cell death . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
After neutrophils were incubated with HPWE , expression of Bcl 2 family [ antiapoptotic ( Bcl 2 , Bcl XL and Mcl 1 ) and proapoptotic ( Bax , Bak and Bcl XS ) ] was determined by RT PCR and Western blotting , respectively . ^^^ The expression of Bax and Bak was upregulated and Bcl 2 , Bcl XL and Mcl 1 downregulated in HL 60 cells during neutrophilic differentiation . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Enriched broth cultures ( EBC ) , cell pellets ( CP ) , or phosphate buffered saline washed cell pellets ( PBSCP ) from enriched sponge samples were compared for detection of E . coli O 157 : H 7 , S . typhimurium DT 104 , or L . monocytogenes by the PCR using the BAX ( TM ) system . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
We evaluated the expression of apoptosis regulating proteins ( p 53 , Bcl 2 , Bax , Bak and Mcl 1 ) in paraffin embedded tissues of 33 patients with diffuse large B cell non Hodgkin ' s lymphoma , and assessed the relationship of these proteins to clinical outcome and response to chemotherapy . ^^^ Bcl 2 , Bax , Bak and Mcl 1 proteins , though highly expressed in almost all cases were not associated with prognosis or response to treatment . . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
An increase in the pro apoptotic protein , bax , and a decrease in the anti apoptotic protein , Mcl 1 , were detected in fisetin and wogonin treated HL 60 cells . ^^^ In conclusion , our experiments indicate that a decrease in intracellular peroxide level was involved in wogonin and fisetin induced apoptosis ; activation of caspase 3 and endonuclease , induction of bax protein and suppression of Mcl 1 protein were detected in the process . . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Expression of Bcl 2 , Bcl 10 , Mcl 1 , Bax and Bak in human uterine leiomyomas and myometrium during the menstrual cycle and after menopause . ^^^ To investigate the expression of Bcl 2 , Bcl 10 , Mcl 1 , Bax and Bak proteins in human uterine leiomyomas and homologous myometrium during the menstrual cycle and after menopause . ^^^ The expression of Bcl 2 , Bcl 10 , Mcl 1 , Bax and Bak in leiomyomas ( n=24 ) and myometrial samples ( n=22 ) from women with leiomyomas was measured by immunohistochemistry and Western blot . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
The expression of thymidylate synthase ( TS ) , p 53 , retinoblastoma protein ( Rb ) , Fas receptor , Fas ligand , bcl 2 , mcl 1 , bax , and bcl 10 was measured using immunohistochemistry . ^^^ The expression of bax , mcl 1 , and bcl 10 in normal mucosa was more apical than that seen in malignant cells , where a more diffuse expression pattern was seen ( p < 0 . 04 ) . ^^^ CONCLUSIONS : These results demonstrate that proliferation and apoptosis are disturbed during colorectal cancer progression , and this is accompanied by loss of Rb and Fas expression , the accumulation of p 53 and TS , and changes in the expression patterns of bax , mcl 1 , and bcl xl . . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Ribonuclease protection assays compared the effects of acetaminophen and E 2 on expression of selected genes ( c myc , c fos , cyclin D 1 , bcl 2 , bax , gadd 45 , mcl 1 , p 53 , p 21 ( CIP1 / WAF1 ) , and bcl xL ) in E 2 responsive breast cancer ( MCF 7 ) and endometrial adenocarcinoma ( Ishikawa ) cells as well as in E 2 nonresponsive ( MDA MB 231 ) breast cancer cells . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
To investigate the potential role of the BCL 2 gene family ( BAX , BCL 2 , MCL 1 , and BCL XL ) in ovarian cancer development and progression , mRNA expression levels of these genes were measured using semi quantitative PCR in epithelial ovarian tumor tissues and normal ovaries . ^^^ The expression levels of BAX and MCL 1 mRNA were significantly higher in ovarian cancers and in adenomas than in normal ovaries ( P < 0 . 05 ) . ^^^ Log rank testing showed that low BAX mRNA expression and high MCL 1 mRNA expression significantly correlate with poor survival for patients with stage 3 ovarian carcinomas ( BAX , P = 0 . 05 ; MCL 1 , P = 0 . 02 ) . ^^^ These results suggest that increased MCL 1 expression may play an important role in replacing the functions of increased BAX and decreased BCL 2 in ovarian carcinoma cells , thereby promoting cell survival , and resulting in a poor prognosis for patients with ovarian cancer . . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
In the ZS cells , bax and mcl 1 were also approximately 50 % higher compared with ZN controls , whereas bcl 2 mRNA was increased compared with ZA cells . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
We investigated the expression of Mcl 1 , Bcl 2 , Bax , and BAD at 13 21 gestational wk in the human fetal ovary and of Mcl 1 in the adult ovary . mRNA expression of Mcl 1 and its short form Mcl 1s , Bcl 2 , Bax , and BAD was demonstrated in fetal ovary by RT PCR . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
It has been proposed that Bax does not translocate to mitochondria under normal physiological conditions , due to interaction between amino ( ART ) and carboxy ( TM ) terminal domains . ^^^ Here , we report the physiological consequences of introducing a matrix targeting mitochondrial signal sequence ( Su 9 ) at the amino terminus of Bax and its mutants lacking ART , TM , or both segments . ^^^ When ART , TM , or both segments of Bax were deleted , expression of fusion proteins containing Su 9 resulted in apoptosis via cytochrome c release . ^^^ We thus demonstrate that an effective mitochondrial matrix targeting signal can override the inhibition of import of Bax to the organelle , presumed to arise as a result of interaction between ART and TM segments , in the absence of apoptotic stimulus . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Other genes involved in the regulation of apoptosis , such as human inhibitor of apoptosis 1 ( HIAP 1 ) , Bax inhibitor 1 and MCL 1 , or DNA repair , such as poly ( ADP ribose ) polymerase 1 ( PARP 1 ) , 10 associated protein 1 ( XAP 1 ) , SUMO 1 ( sentrin 1 ) and RanGTPase activating protein 1 ( RanGAP 1 ) , were isolated . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
LOX inhibitor treatment also reduced the levels of anti apoptotic proteins Bcl 2 and Mcl 1 and increased the levels of the pro apoptotic protein bax . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
To analyze the mechanisms of the apoptotic activity of Cl F araA , we sought to determine the effects of the drug on the levels of Bcl 2 family proteins ( Bcl 2 , Bcl 10 ( L ) , Mcl 1 , Bax , Bak ) and cell survival signals via Akt . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
We have investigated whether subsets of indolent B cell non Hodgkin ' s lymphoma ( IB NHL ) differ in the expression of the bcl 2 family members ; 116 cases of IB NHL , composed of chronic lymphocytic leukemia ( CLL , n = 48 ) , follicular lymphoma ( FL , n = 38 ) , marginal zone B cell lymphoma ( MZBCL , n = 15 ) , and mantle cell lymphoma ( MCL , n = 15 ) , were investigated for expression of bcl 2 , bcl 10 , mcl 1 , bax , and bak proteins by immunohistochemistry . ^^^ The different subsets of IB NHLs differ in their expression of mcl 1 , bax , and bak proteins . . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Moreover , Rho inhibition reduced expression of antiapoptotic Bcl 2 and Mcl 1 and increased proapoptotic Bid but had no effect on Bax or FLIP protein levels . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
CD 437 mediated apoptosis was not associated with the modulation of Bcl 2 , Bax , or Mcl 1 levels , but was associated with the cleavage of the antiapoptotic protein Bcl 10 ( L ) to a proapoptotic 18 kD form . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
The Bcl 2 , Mcl 1 , Bcl xL / S , Bcl w , Bax , Bak , and Bad were shown to be expressed in both malignant and non neoplastic , normal plasma cells . ^^^ Quantitative analysis revealed that the malignant phenotype seemed to correlate with an elevated expression of Mcl 1 , a decreased expression of Bax and , to a lesser extent , an increased Bcl 2 / Bax expression ratio . ^^^ Furthermore , the anti apoptotic proteins Bcl 2 , Mcl 1 and Bcl xL were down regulated , while the expression of the pro apoptotic Bax protein was increased . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
A decrease in the anti apoptotic protein , Mcl 1 , was detected in emodin treated HL 60 cells , whereas other Bcl 2 family proteins including Bax , Bcl 2 , Bcl XL , and Bad remained unchanged . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Using cultured prostate cancer ( PC ) cell lines , LN CaP and ALVA 31 , we studied the effects of 1alpha , 25 ( OH ) 2 Vitamin D 3 ( VD 3 ) on expression of several apoptosis regulating proteins including : ( a ) Bcl 2 family proteins ( Bcl 2 , Bcl 10 ( L ) , Mcl 1 , Bax , and Bak ) ; ( b ) the heat shock protein 70 binding protein BAG1L ; and ( c ) IAP family proteins ( XIAP , cIAP 1 , and cIAP 2 ) . ^^^ VD 3 induced decreases in levels of antiapoptotic proteins Bcl 2 , Bcl 10 ( L ) , and Mcl 1 , BAG1L , XIAP , cIAP 1 , and cIAP 2 ( without altering proapoptotic Bax and Bak ) in association with increases in apoptosis . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Expression of the antiapoptotic proteins Bcl 2 and Mcl 1 was significantly decreased after LOX inhibitor treatment while that of the proapoptotic protein bax was increased . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
The role of Mcl 1 and Bax expression alteration in the decreased rescue of human neutrophils from apoptosis by GM CSF with aging . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Treatment with Epo B followed by FP induced more Bax conformational change and was associated with a greater decline in the levels of XIAP , cIAP 2 , Mcl 1 , and Bcl 10 ( L ) . ^^^ Taken together , these findings suggest that the superior sequence dependent anti breast cancer activity of Epo B followed by FP may be due to FP induced Bax conformational change and down regulation of the antiapoptotic IAP , Bcl 10 ( L ) , and Mcl 1 proteins , but this treatment may not overcome the resistance to apoptosis of breast cancer cells conferred by overexpression of Bcl 2 . . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Treatment with G 3139 led to a sequence specific reduction of Bcl 2 protein levels within 4 days of exposure in 10 out of 11 clinical samples from patients with chemosensitive and multidrug resistant disease , without significant reduction of alpha Actin , Bax , Bcl XL , or Mcl 1 proteins . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
This increased apoptosis was accompanied by decreased antiapoptotic bcl 2 mRNA expression among bcl 2 related genes ( bcl 2 , bax , bak , mcl 1 , and bcl 10 ( L / S ) ) , and the effect was also more prominent in the cagA ( + ) strains . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
The expression of apoptosis related genes BCL 2 , BAX , BCL2L1 , BCL2A1 , MCL 1 , DAPK 1 and MYC was studied by quantitative real time polymerase chain reaction on total RNA samples from patients with acute lymphoblastic leukaemia ( ALL , n = 16 ) , acute myeloid leukaemia ( AML , n = 27 ) , chronic myeloid leukaemia ( CML , n = 12 ) , mantle cell lymphoma ( MCL , n = 19 ) and chronic lymphoid leukaemia ( CLL , n = 32 ) . ^^^ BCL 2 , BAX , BCL2A1 , MCL 1 , DAPK 1 and MYC were overexpressed in all patient groups . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
We report herein that human oocytes and preimplantation embryos possess abundant levels of transcripts encoding cell death suppressors , Mcl 1 , Bcl 10 and Bag 1 , and the cell death inducer genes , Bax and Caspase 2 . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
It was hypothesized that the expression of proapoptotic ( Bax ) and prosurvival ( Bcl 2 and Mcl 1 ) proteins would be altered in neuroblastoma cells grown in a cell culture model of metastatic neuroblastoma . ^^^ Bcl 2 , Mcl 1 , and Bax mRNA were measured with reverse transcriptase polymerase chain reaction ( RT PCR ) . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Changes in other apoptotic proteins , including Bcl 2 , Bax , Mcl 1 , and 10 linked inhibitor of apoptosis ( XIAP ) , were not observed . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
NO 2 in supernate , the proliferation and apoptosis of TM cells and mRNA expression of bcl 2 and bax were measured by Griess reagent , terminal deoxynucleotidyl transferase mediated dUTP nick end labeling ( TUNEL ) , MTT assay and in situ hybridization , respectively . ^^^ The results showed that L arginine with concentration > or = 1 10 10 ( 4 ) mol / L could induce apoptosis of the TM cells and inhibit the proliferation of TM cells through increasing the NO levels , down regulating bcl 2 mRNA expression and up regulating bax mRNA expression ; L NAME with concentration > or = 1 10 10 ( 5 ) mol / L could induce the proliferation of the TM cells through suppressing the production of NO . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
To investigate whether the Bcl 2 gene family is involved in modulating mechanism of apoptosis and change of cell cycle protein induced by curcumin in acute myeloid leukemia HL 60 cell line and primary acute myelogenous leukemic cells , the Bcl 2 family member Mcl 1 , Bax and Bak and cell cycle proteins including P27kipl , P21wafl , cyclin D 3 and pRbp were selected and their expression detected by SABC immuno histochemical stain method . ^^^ It was found that when HL 60 cells were treated with 25 mumol / L curcumin for 24 h , the expression level of Mcl 1 was down regulated , but that of Bax and Bak up regulated time dependently . ^^^ There was significant difference in the expression level of Mcl 1 , Bax and Bak between the curcumin treated groups and control group ( P < 0 . 05 0 . 01 ) . ^^^ At the same time , curcumin had no effect on progress of cell cycle in primaty acute myelogenous leukemia at newly diagnosis , but could increase the peak of Sub G 1 ( P < 0 . 05 ) , and down regulate the expression of Mcl 1 and up regulate the expression of Bax and Bak with the difference being statistically significant . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
We therefore developed a four color flow cytometry method that enables establishment of apoptosis related protein expression such as Bcl 2 , Bcl 10 ( L ) , Mcl 1 and Bax at diagnosis and in MRD . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Immunohistochemistry was used on paraffin sections to detect LMP 1 / EBV , CD 15 and the apoptosis related proteins ( bcl 2 , bax , bcl 10 , mcl 1 and CD 95 ) . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
RESULTS : We show that CD34+ AML fractions are more resistant to apoptosis than are corresponding CD 34 AML fractions , and that this is paralleled by higher Bcl 2 , Bcl xL , Mcl 1 , Pgp and lower Bax expression levels . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Hypoxia induced cell cycle arrest at the G0 / G1 phases and massive cell apoptosis after 24 hours through a reduction in the Bcl 2 to Bax ratio , downregulation of Bcl XL and Mcl 1 , and upregulation of caspase 3 and caspase 8 . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
The present study investigated expression levels of the anti apoptotic proteins BCL 2 , BCL XL and MCL 1 and the pro apoptotic proteins BAX and BCL XS in a series of 112 peripheral T cell lymphomas ( PTCLs ) classified according to the WHO classification . ^^^ Using immunohistochemical methods and a 10 % cut off , each protein was detected in a subset of PTCLs : BCL 2 in 46 % , BCL XS in 49 % , BAX in 57 % , BCL XL in 57 % , and MCL 1 in 65 % . ^^^ The proliferation index , assessed by the MIB 1 antibody , correlated with expression levels of MCL 1 ( R = 0 . 42 , p = 0 . 003 ) , BCL 2 ( R = 0 . 32 , p = 0 . 027 ) , BAX ( R = 0 . 33 , p = 0 . 014 ) , and BCL XL ( R = 0 . 34 , p = 0 . 015 ) ( Spearman rank ) . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
This study examined cutaneous T cell lymphoma ( CTCL ) cell lines and cutaneous lesions for the presence of Bcl 2 gene family members and found that the two apoptosis inhibiting members Bcl xL and Mcl 1 and the two apoptosis supporting members Bad and Bax were expressed . ^^^ The Bcl 10 , Mcl 1 , Bad , and Bax proteins were also expressed in all CTCL skin lesions tested . ^^^ Overexpression of Mcl 1 and synthesis of non functional Bax may be responsible for the resistance of CTCL cells to the anti cancer drugs chlorambucil and sulindac . . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
It was revealed that LIGHT treatment resulted in down regulation of anti apoptosis Bcl 2 family member : Bcl 2 , Bcl 10 ( L ) , Bag 1 , and Mcl 1 ; up regulation of pro apoptosis Bcl 2 family member : Bak and Ser ( 112 ) phosphor Bad ; down regulation of pro apoptosis Bcl 2 member Bax ; the other pro apoptosis member Bid remains unaltered . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Furthermore , Bax and Bag 1 possible heterodimeric partners for EAT in the anti apoptotic process were up regulated in islets isolated from the EAT transgenic mice . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
The disappearance of Mcl 1 is also required for other mitochondrial apoptotic events including Bax translocation , cytochrome c release , and caspase activation . . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
At day 7 , in controls , vascular injury upregulated antiapoptotic mediator Mcl 1 and Bcl xL expression by 8 fold to 5 fold , respectively , versus sham , whereas proapoptotic Bax slightly increased by 1 . 5 fold versus sham . ^^^ AxCAdnSTAT 3 reversed the upregulated Mcl 1 and Bcl xL levels by 70 % and 37 % , respectively , while having no affect on Bax expression . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Remarkably , these events occurred in the absence of any reduction in the expression of the Bcl 2 family members Bcl 2 , Mcl 1 , and Bcl xL or any change in the proapoptotic molecules Bad or Bax . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
A decrease in the anti apoptotic protein , Mcl 1 , was detected in QUE treated HL 60 cells , whereas other Bcl 2 family proteins including Bax , Bcl 2 , Bcl XL , and Bag remained unchanged . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
In contrast , treatment of cells with LY 294002 , to inhibit phosphoinositide 3 kinase ( PI3K ) , caused downregulation of Bcl 2 and Mcl 1 and allowed deltaMEKK 1 : ER * to elicit a robust apoptotic response characterized by activation of Bax and caspases . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Expression of the anti apoptosis proteins , Bcl 2 and Mcl 1 expression decreased time dependently while Bax expression increased . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Western blot analysis of the expression of various Bcl 2 family members in betulinic acid treated cells showed , surprisingly , a suppression of the expression of the proapoptotic protein Bax but no changes in Mcl 1 or Bcl 2 expression . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
A decrease in the anti apoptotic protein , Mcl 1 , was detected in HT and NE treated HL 60 cells , whereas other Bcl 2 family proteins including Bax , Bcl 2 , Bcl XL , and Bag remained unchanged . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Furthermore , when the B CLL patients were analysed according to P2X7 genotype ( 1513 A / A versus 1513 A / C ) , there was no significant difference in age at diagnosis , stage at diagnosis , lymphocyte doubling time , time to first treatment , progression free survival and overall survival , and neither was there any evidence of bias in terms of VH gene mutational status , CD 38 expression , in vitro sensitivity to fludarabine or expression of Bcl 2 , Bax or Mcl 1 between the two groups . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
These events were associated with Bcl 2 cleavage , Bax , Bak , and Bad accumulation , mitochondrial translocation of Bax , abrogation of Mcl 1 , Bcl xL , and XIAP upregulation , and a marked induction of JNK and p 53 . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
The general consensus in the literature is that pro apoptotic Bax is decreased with melanoma progression while anti apoptotic Bcl xL and Mcl 1 appear to increase with progression . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
To investigate the mechanisms responsible for survival and apoptosis / anoikis in normal human intestinal epithelial crypt cells , we analyzed the roles of various signaling pathways and cell adhesion on the expression of six Bcl 2 homologs ( Bcl 2 , Bcl XL , Mcl 1 , Bax , Bak , Bad ) in the well established HIEC 6 cell model . ^^^ For example , the inhibition of the PI 3 K / Akt 1 pathway down regulated Bcl XL , Mcl 1 , and Bad , while at the same time up regulating Bax , whereas the inhibition of Fak up regulated both Bax and Bak , down regulated Bad , and did not affect the other Bcl 2 homologs analyzed . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Upon loss of the MCL 1 BAK complex , BAK complexed with either BAX in proapoptotic E1B mutant adenovirus infected cells , or with the adenovirus BCL 2 homolog E1B 19K in cells infected with the wild type virus in which apoptosis is inhibited . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
In this study , expression of Mcl 1 , Bid , Bcl 2 , and Bax were investigated in septic neutrophils . ^^^ Mcl 1 , Bid , Bcl 2 , and Bax mRNA expression was detected by reverse transcriptase polymerase chain reaction and protein determined by Western blot analysis . ^^^ The upregulation of Mcl 1 mRNA in patients with sepsis suggests an active role for Mcl 1 in regulation of apoptosis during sepsis ; Bax remains unchanged . . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Tissue sections were examined immunohistochemically for expression of proapoptotic proteins ( Bax , p 53 ) , antiapoptotic proteins ( Bcl 2 , Mcl 1 ) , and spontaneous apoptosis ( M 30 ) . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Mcl 1 and Bcl 2 / Bax ratio are associated with treatment response but not with Rai stage in B cell chronic lymphocytic leukemia . ^^^ Although both Bcl 2 / Bax ratio and Mcl 1 have been identified to be of clinical relevance in B cell chronic lymphocytic leukemia ( CLL ) , there is controversy regarding their role ; further , their relative importance is not well delineated . ^^^ Expression of Bcl 2 , Bax , the Bcl 2 / Bax ratio , and Mcl 1 in 51 consecutive previously untreated CLL patients and 16 controls was determined by Western blotting . ^^^ Low Mcl 1 appears to be a requirement for CR , while low Bcl 2 / Bax ratio is indicative of some response to conventional treatment . . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Of the apoptotic mediators tested , the anti apoptotic protein Bcl 10 ( L ) was strongly down regulated by combined treatment of the cells with SBHA and TRAIL but not by the HDAC inhibitor alone , while little or no change in the expression of other Bcl 2 family members highly expressed in MM cells , including Mcl 1 and Bax , was observed . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Resveratrol selectively down regulated the expression of antiapoptotic proteins Bcl 10 ( L ) and myeloid cell differentiation factor 1 ( Mcl 1 ) and up regulated the expression of proapoptotic proteins Bax and apoptosis protease activating factor 1 ( Apaf 1 ) . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Spontaneous apoptosis of B CLL cells by in vitro culture resulted in decreased bcl 2 , bcl w , bfl 1 , mcl 1 , bak , bax , and bcl 2 / bax expression . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
However , the DN forms of STAT 5 did not alter the expression of Bcl 2 , Bax , Bcl 10 , Bim , A 1 and Mcl 1 proteins in IL 7 stimulated cells . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
METHODS : The parameters reflecting cell proliferation and cell death were studied together with oxidative response , mitochondrial membrane potential ( MMP ) and changes of selected regulatory molecules associated with cell cycle ( p 27 ( Kip 1 ) and p 21 ( Cip1 / WAF1 ) ) and apoptosis ( caspase 3 , caspase 9 , poly ( ADP ribose ) polymerase PARP , Bcl 2 , Bax , Bak , Mcl 1 ) . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
According to prediction methods , there are only two putative TM fragments in Bcl 10 ( L ) and Bax ( the C terminal alpha helix and alpha helix 5 ) and one in activated tBid ( alpha helix 6 ) . ^^^ Subsequent analysis by glycosylation mapping of single alpha helix segments in a model chimeric system confirms the above predictions and allows finding an extra TM fragment made of helix alpha 1 of Bax . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Western blotting was used for caspase 3 and PARP , caspase 7 , caspase 9 , cytochrome c , Bcl 2 , Bax , Mcl 1 , cyclinA , cyclin B 1 , cyclin D 1 , cyclin E , CDK 2 , CDK 4 , CDK 6 , P 21 , P 27 , GADD 45 , GADD 153 . ^^^ The anti apoptosis proteins Bcl 2 and Mcl 1 were decreased in parallel and Bax increased , indicating that Bcl 2 family proteins mitochondria caspase cascade was responsible for oil induced apoptosis . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Treatment with BMS 214662 induced loss of mitochondrial membrane potential ( DeltaPsi ( m ) ) , phosphatidylserine exposure , proapoptotic conformational changes of Bax and Bak , reduction in Mcl 1 levels and activation of caspases 9 and 3 . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Under apoptosis induction , the disappearance of Mcl 1 allows Bim to exercise its pro apoptotic function and to activate Bax . . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
We also analyzed caspase 3 , 7 , 8 , 9 , Bcl 2 , Bax , Bid , and cytochrome C by Western analysis , and mitochondrial permeability and reactive oxygen species production by flow cytometry using mitosensor ( TM ) and DCFH DA , respectively . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
The expression of Bcl 2 family members , Bcl xL , Bcl 2 , Mcl 1 and Bax was investigated in delayed apoptosis of canine neutrophils induced by lipopolysaccharide ( LPS ) . ^^^ The levels of Bcl xL , Bcl 2 , Mcl 1 and Bax transcripts at 9 h incubation in neutrophils stimulated by LPS ( 100 ng / ml ) were increased by about 80 . 4 , 1 . 9 , 1 . 4 and 5 . 3 folds , in comparison to those in non stimulated neutrophils , respectively . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Differences in mcl 1 , bax , bcl w , bad or bak mRNA levels in infected versus uninfected neutrophils were not remarkable . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Cotreatment with 17 AAG and SAHA also induced down regulation of Mcl 1 , Bcl xL , and B Raf ; up regulation of Bak ; cleavage of 14 3 3 proteins ; and a profound conformational change in Bax accompanied by translocation to the membrane fraction . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Combined exposure to flavopiridol and HA 14 1 was associated with down regulation of Mcl 1 and Bcl xL , Bid cleavage , and mitochondrial translocation of Bax . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Placental tissues were examined for a ) Brd U ( immunohistochemistry ) and b ) apoptosis regulatory genes by in situ hybridization , Northern analyses ( bax , mcl 1 ) , immunohistochemistry , and Western analyses ( bax ) . ^^^ Bax and mcl 1 mRNA were localized to the maternal fetal interface . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Several BH 3 peptides relieved the inhibition of Bax caused by the antiapoptotic Bcl 10 ( L ) and / or Mcl 1 proteins , some displaying a specificity for either Bcl 10 ( L ) or Mcl 1 . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Farnesyltransferase inhibitor BMS 214662 induces apoptosis in myeloma cells through PUMA up regulation , Bax and Bak activation , and Mcl 1 elimination . ^^^ BMS 214662 treatment increased levels of the BH 3 only protein PUMA ; induced proapoptotic conformational changes of Bax and Bak ; reduced Mcl 1 levels ; caused mitochondrial transmembrane potential loss ; induced cytochrome c release , caspase activation , apoptosis inducing factor ( AIF ) nuclear translocation , and phosphatidylserine exposure ; and allowed the development of apoptotic morphology . ^^^ However , Z VAD fmk did not prevent BMS 214662 induced Bax and Bak activation and decrease of Mcl 1 levels . ^^^ These results suggest that apoptosis triggered by BMS 214662 is initiated by a PUMA / Bax / Bak / Mcl 1 dependent mechanism . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
RA repressed c fos mRNA expression in control and irradiated SiHa cultures , but did not repress bcl 10 ( L ) , p 53 , GADD 45 , p 21 , bax , bcl 2 , or mcl 1 mRNA expression . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Exposure of B CLL cells to honokiol resulted in up regulation of Bcl 2 associated protein ( Bax ) and down regulation of the expression of the key survival protein myeloid cell leukemia sequence 1 ( Mcl 1 ) , which is associated with response to treatment in B CLL patients . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Here we review the significance of apoptosis dysregulation in CLL , focusing on the role of Bcl 2 and related Bcl 2 family proteins , such as Bax and Mcl 1 . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Additionally , expression of the apoptosis regulating proteins Bax , Bak , Bid , Bcl w , Bcl 2 , XIAP and Mcl 1 was evaluated in B CLL lymphocytes . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
EXPERIMENTAL DESIGN : We studied whether Bcl 2 , Bcl xL , Mcl 1 , Bax as well as the Bcl 2 / Bax ratio and a combination of all ( antiapoptosis index , AAI ) are related to the frequency of malignant cells surviving the chemotherapy ( i . e . , minimal residual disease , MRD ) . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Skin biopsies of LyP ( n = 20 ) and LTCL ( n = 19 ) and five CD30+ lymphoma cell lines were analysed by means of immunohistochemistry and Western blotting in order to evaluate the proliferation ( Ki 67 ) , apoptosis ( FragEl ) and expression of Bax , Bcl 10 , C kit and Mcl 1 . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
This work describes the isolation of cDNA and genomic fragments from five sheep BCL 2 related genes : BCL 2 , BCL2L1 , BCL2L2 , BAX and MCL 1 . ^^^ Intron polymorphisms were used for linkage mapping of BAX and MCL 1 , which were mapped on OAR 14 and OAR 1 respectively . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Furthermore , the effect of 3 microM clavulone 2 was accompanied by the up regulation of Bax , down regulation of Mcl 1 , and cleavage of Bid . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
The p 53 siRNA treated KCs were characterized by elevated E2F 1 levels accompanied by accelerated elimination of the Mcl 1 and Bcl 10 ( L ) antiapoptotic proteins , as well as enhanced Bax oligomerization . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
When neutrophils were incubated with LTB 4 for 1 to 6 h , the mRNA levels of the anti apoptotic protein Mcl 1 were upregulated approximately 2 fold , while those of the pro apoptotic protein Bax were downregulated 3 to 4 fold , as determined by real time PCR . ^^^ Accordingly , Western blot analysis revealed that the expression of Mcl 1 was upregulated in presence of LTB 4 , while flow cytometric analysis revealed that Bax protein was downregulated . ^^^ Furthermore , the modulatory effects of LTB 4 on Mcl 1 and Bax proteins were abolished in the presence of either wortmannin or PD 98059 . ^^^ Taken together , these results demonstrate the participation of PI 3 K and MEK / ERK kinases , as well as regulatory apoptotic proteins such as Mcl 1 and Bax , in the anti apoptotic effects of LTB 4 in human neutrophils . . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Further studies were conducted to compare these changes to the localization and expression of the bcl 2 group of proteins bcl 10 , bax and mcl 1 , and Fas Fas ligand in the same cells . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
The survival function of IL 7 is largely through maintaining a favorable balance of bcl 2 family members including Bcl 2 itself and Mcl 1 on the positive side , and Bax , Bad and Bim on the negative side . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Cultured Nb cells were sensitized to alpha TOS by pre treatment with Bcl 2 , Bcl xL or Mcl 1 siRNAs , while the malignant cell line was more resistant to the vitamin E analogue when Bax was knocked down . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
The expression levels of Mcl 1 and Bcl XL but not those of Bcl 2 , Bax , and Bak were suppressed by TSA or SK 7041 treatment . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
This pathway is regulated by bcl 2 family of anti apoptotic ( bcl 2 , bcl xl , mcl 1 ) and pro apoptotic proteins ( bax , bad , bak ) . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Western blot data revealed that NO gas increased the expressions of anti apoptosis proteins ( Bcl 2 and Mcl 1 ) and decreased the expression of apoptosis proteins ( Bax , t Bid , cytochrome c , FasL , and caspases ) after B [ a ] P treatment . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Results also displayed that PEITC induced apoptosis involves the up regulation of p 53 and Bax protein , down regulation of the XIAP , Bcl 2 , Bcl ( XL ) and Mcl 1 proteins , cleavage of Bid , and the release of cytochrome c and Smac / Diablo , which were accompanied by the activation of caspases 9 , 3 and 8 . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
The disappearance of full length Mcl 1 allows the release of Bim isoforms , particularly L and S , which can exert their proapoptotic function and leads to Bax activation and cytochrome c release . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
HDAC inhibitors enhance the apoptosis inducing potential of TRAIL in leukemia cells ( HL 60 , Jurkat , K 562 , and U 937 ) through multiple mechanisms ; up regulation of DR 4 , DR 5 , Bak , Bax , Bim , Noxa and PUMA , down regulation of IAPs , Mcl 1 , Bcl 2 , Bcl XL and cFLIP , release of mitochondrial proteins ( cytochrome c , Smac / DIABLO and Omi / Htr2 ) to the cytosol , induction of p21WAF1 / CIP1 and p27KIP1 , activation of caspase 3 and cleavage of poly ( ADP ribose ) polymerase ( PARP ) . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Interestingly , Mcl 1 was down regulated as well , although levels of Bax , Bad , or Bak were not altered after treatment with this bispecific antisense oligonucleotide . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Mcl 1 was critical for the survival of RA synovial fibroblasts , because the forced reduction of Mcl 1 using a Mcl 1 antisense expressing adenoviral vector induced apoptotic cell death , which was mediated through Bax , Bak , and Bim . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Immunohistochemical evaluation showed that CS treatment produced an increase in the cellular levels of Bax , t Bid , cleaved caspase 3 , phospho p 53 , phospho JNK , and FasL but a decline in Bcl 2 and Mcl 1 ( p < 0 . 001 for all ) in rat terminal bronchioles . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Cytotrophoblasts also expressed a 2 fold higher level of p 53 , a 2 fold lower level of 60 kDa Mdm 2 protein , a 2 fold higher level of Bak , but no differences in the expression of 90 kDa Mdm 2 , Bcl 2 , Bcl 10 ( L ) , Mcl 1 , Bax , Bad , and Bad phosphorylated at the serine ( 112 ) , serine ( 136 ) , or serine ( 155 ) sites , compared to the syncytiotrophoblasts . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
In addition to its ability to interact directly with Bax and Bak , tBid also binds Mcl 1 and displaces Bak from the Mcl 1 Bak complex . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Bouin ' s fixed fetal ovaries were examined for ( a ) Ki 67 immunoexpression ( proliferation ) and ( b ) Bax and Mcl 1 ( apoptosis regulating genes ) expression by in situ hybridisation ( day 110 ) and immunohistochemistry ( days 50 , 65 and 110 ) . ^^^ At day 50 , maternal nutrition had no effect on Ki 67 , predominant in germ cells , or Bax and Mcl 1 , predominant in the oocytes . ^^^ In animals fed the L ration for 110 days , primordial follicle Bax and Mcl 1 were significantly increased ( Bax : P < 0 . 01 ; Mcl 1 : P < 0 . 05 ) . ^^^ When the L ration was fed from 66 to 110 days , granulosa cell Bax ( P < 0 . 05 ) and primordial follicle Mcl 1 ( P < 0 . 01 ) were also significantly increased . ^^^ In the fetal ovarian vasculature , animals underfed for 0 110 days had significantly elevated perivascular Mcl 1 ( P < 0 . 001 ) and endothelial Bax expression ( P < 0 . 05 ) . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
The pro apoptotic Bcl 2 family proteins , Bak , Bax , and Bim have been shown to be required for disruption of mitochondria and intrinsic cell death of self reactive B cells whereas the anti apoptotic Bcl 2 , Bcl xL , and Mcl 1 can prevent cell death by interfering with the action of Bax and Bak . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Apoptosis induced by each TM was associated with a significant ( approximately 400 % ) increase in caspase 8 activity , but no change in caspase 9 activity , and Western analyses revealed a marked up regulation of Fas ( approximately 500 % ) and FADD ( approximately 300 % ) with no change in expression of Bax , Bcl 2 , or Bcl xL . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Another glial activation related gene ( CTSS ) was slightly up regulated in obex , whereas constitutive expression was detected for SOD 1 , YWHAZ , PRNP , and the apoptosis related genes BCL 2 , MCL 1 , and BAX . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
To determine whether this phenomenon results from altered expression of Bcl 2 or related proteins , Northern and Western analysis was employed to assess the effects of bryostatin 1 and other PKC activators on steady state levels of Bcl 2 , Bax , Bcl 10 , and Mcl 1 mRNA and protein . ^^^ These effects were accompanied by unaltered expression of Bcl 2 , Bax , and Bcl 10 ( L ) , and by a further increase in Mcl 1 protein levels . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
We investigated possible effects of different statins in vitro in human adult cardiac myocytes on the expression of proteins thought to be involved in the regulation of apoptosis such as Mcl 1 , an inhibitor of apoptosis , Bax , an inducer of apoptosis , as well as on cytoplasmic histone associated DNA fragments . ^^^ Simvastatin but not pravastatin reduced Mcl 1 protein expression whereas Bax protein was not detectable in HACM as determined by Western blotting . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Exposure of U 937 and other leukemia cells to SU 9516 concentrations > or =5 microM rapidly ( i . e . , within 4 h ) induced cytochrome c release , Bax mitochondrial translocation , and apoptosis in association with pronounced down regulation of the antiapoptotic protein Mcl 1 . ^^^ Ectopic expression of Mcl 1 largely blocked SU 9516 induced cytochrome c release , Bax translocation , and apoptosis , whereas knockdown of Mcl 1 by small interfering RNA potentiated SU 9516 lethality , confirming the functional contribution of Mcl 1 down regulation to SU 9516 induced cell death . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Interestingly , Bcl 2 / Bcl xL bispecific ASO treatment also resulted in the down regulation of Mcl 1 and up regulation of Bax . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
The proapoptotic proteins Bax and Bak are required for MOMP , while the antiapoptotic Bcl 2 proteins , including Bcl 2 , Bcl xL , Mcl 1 , and others , prevent MOMP . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Tumor sections were analyzed by immunohistochemistry for the expression of regulators of the cell cycle ( p 21 ; retinoblastoma protein ( pRb ) ) , of the intrinsic or extrinsic proapoptotic pathways ( p 53 ; murine double minute gene 2 protein ; tumour necrosis factor related apoptosis inducing ligand ( TRAIL ) R1 / DR4 ; TRAIL R2 / DR5 ) and of Bcl 2 related proteins ( Bcl 2 , Mcl 1 , Bax , Bak , Bok ) , which regulate the common mitochondrial apoptotic pathway . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
In conclusion , these observations support a prominent role for CAR cytoprotection against Fas mediated hepatocyte injury via a mechanism involving upregulation of Mcl 1 and , likely , downregulation of Bax and Bak . . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
COX 2 inhibition led to a rapid down regulation of myeloid cell leukemia 1 ( Mcl 1 ) , an antiapoptotic member of the Bcl 2 family , followed by translocation of Bax to mitochondria and cytochrome c release from mitochondria . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
However , the expressions of p 53 or pro or antiapoptotic Bcl 2 family proteins ( Bax , Bcl 2 , Bcl 10 ( L ) and Mcl 1 ) were not affected in any of the cell lines even after prolonged exposure to FB ( 1 ) at high doses . ^^^
Interacting proteins: Q07812 and Q07820	Pubmed	SVM Score :0.0
Its three factions of interacting proteins include the BH 3 only proteins ( e . g . , Bim , Puma , Bad , Noxa ) , which transduce diverse cytotoxic signals to the mammalian pro survival proteins ( Bcl 2 , Bcl 10 ( L ) , Bcl w , Mcl 1 , A 1 ) , whereas Bax and Bak , when freed from pro survival constraint , provoke the mitochondrial permeabilization that triggers apoptosis . ^^^