Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.67873743
Like Bcl xL , h Bcl 10 binds to the pro apoptotic protein Bax , suggesting a functional activity in vivo . . 0.67873743^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.96516458
Although it has been suggested that heterodimerization between Bcl XL and Bax is essential for the anti death activity of Bcl XL ( refs 7 , 8 ) , our results suggest that the interaction with Bax is not required for Bcl XL to exert its death repressing activity . 0.96516458^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.94946544
These results demonstrate that the conserved BH 3 , but not BH 1 or BH 2 , homology region of Bax is necessary for its interaction with Bcl XL in mammalian cells . 0.94946544^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.72777572
We demonstrate the utility of this approach by applying it to clones isolated in a two hybrid screen using Bcl xL as bait , showing that two hybrid derived fragments of Bad and Bax , previously known to interact with Bcl xL , both colocalize and coimmunoprecipitate with Bcl xL . . 0.72777572^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.84790602
Bax interacted similarly with itself as with the apoptosis suppressing family members Bcl 2 and Bcl xL in quantitative two hybrid studies . 0.84790602^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :1.1074486
A small inhibitor of the interaction between Bax and Bcl 10 ( L ) can synergize with methylprednisolone to induce apoptosis in Bcl 10 ( L ) overexpressing breast cancer cells . 1.1074486^^^ CONCLUSIONS : We have identified a small inhibitor of the interaction between Bax and Bcl 10 ( L ) that can synergize with methylprednisolone to induce apoptosis in Bcl 10 ( L ) overexpressing breast cancer cells . . 0.88717149^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :1.345678
Co immunoprecipitation studies revealed that in untreated KB 3 cells inactive cytosolic Bax interacted with Bcl xL , whereas in vinblastine treated cells , activated mitochondrial Bax did not interact with Bcl xL . 1.345678^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.52008338
This dimerization prevents the neutralizing association of Bcl xL with Bax , freeing Bax to perform in a prodeath manner . 0.52008338^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.91333897
Interactions of Bcl xL with Bax and Bak were also evidenced in lysates from high grade prostate cancer tissues . 0.91333897^^^ In vivo interactions of Bcl xL with Bax or Bak in untreated and camptothecin treated LNCaP and PC 3 cells were investigated by means of coimmunoprecipitation . 0.74743406^^^ We investigated the role of antiapoptotic Bcl xL in the progression of prostate cancer as well as the interactions of Bcl xL with proapoptotic Bax and Bak in androgen dependent and independent prostate cancer cells . 0.74265637^^^ In the absence of any stimuli , Bcl xL interacts with Bax and Bak in androgen independent PC 3 cells but only with Bak in androgen dependent LNCaP cells . 0.64027322^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
At least two family members , Bcl xs and Bax , act in opposition to Bcl 2 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Signalling through Fas / APO 1 did not down regulate Bcl 2 or induce its antagonists Bax and Bcl xS . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In addition , activated K ras up regulates bcl 2 but has no effect on bax or bcl 10 expression . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The Bcl 2 family members analyzed were Bcl 2 , Bcl 10 , Bax , Bad , Bak , A 1 , and Mcl 1 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
None of the cytokines tested caused a change in the levels of expression of Bcl 2 , Bax , Bcl 10 , or Bak proteins . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Expression of bcl 2 family members ( bax , bcl 10 ) was modulated by fotemustine , etoposide and cisplatin . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bcl xL , but not bcl 2 and bax mRNA , was highly inducible within 3 h after stimulation . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Co expression of anti apoptotic Bcl xL showed a modest inhibitory effect on the cell death caused by Bax . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The function of BAX is countered by BCL 2 and BCL XL . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Moreover , BCL XL , BCL 2 , and BAX can form ion conductive pores in artificial membranes . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
All four groups displayed similar levels of the death proteins Bax and Bcl xS . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Moreover , enforced dimerization of BAX overrode the protection by BCL XL and IL 3 to kill cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
All three cell lines expressed equal amounts of Bcl 10 ( L ) , Bcl 10 ( S ) and Bax . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
AIDS KS cells expressed fas , bcl 2 , and bcl xL genes but lacked fasL and bax gene expression . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Here , we show by Western blotting that human neutrophils do not express Bcl 2 or Bcl 10 but constitutively express Bax . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Finally , TS1alphabeta survival is independent of Bcl 2 , Bcl 10 , or Bax . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bcl 2 , bcl xL , bcl xS , and bax levels were unaffected by CBFbeta SMMHC . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
CD 437 mediated apoptosis is not accompanied by downregulation of bcl 2 or bcl XL or upregulation of bax . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Overexpression of HA Bax but not Bcl 2 or Bcl XL attenuates 6 hydroxydopamine induced neuronal apoptosis . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bax induced caspase activation and apoptosis via cytochrome c release from mitochondria is inhibitable by Bcl xL . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
There were no significant changes in the levels of Bcl XL , Bax , and p 21 ( WAF 1 ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Mutation of threonine 169 did not affect the binding of Bax to Bax , Bcl 2 , or Bcl 10 ( L ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The induction of p 53 , Bax , and Bcl 10 mRNAs during hyperoxia was to a large extent prevented by KGF . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
BA enhances the levels of BAX and BCL 2 proteins but does not alter the levels of BCL xS or BCL xL . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The expression of Bcl 2 , Bcl xL , or Bax was largely unaffected . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The levels of Bcl 2 , Bcl xL , and Bax were not altered by cisplatin treatment and mitogen rescue . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The Bcl 2 family members , Bcl 2 , Bcl xl , and Bax , appear not to be involved in this process . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
No marked differences were seen in the regulation of Stat 5 , Bcl 10 ( L ) , or Bax in the absence of Stat 3 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Other proteins important in apoptotic control , Bax , Mcl 1 , and Bcl 10 ( S ) , are unaffected by calcitriol treatment . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
IRS 2 but not IRS 3 binds to Bcl 2 , and IRS 1 associates with Bcl XL but not with Bax or Bik . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Etoposide diminished the binding between Bax and Bcl XL but this was restored by IL 4 and VCAM 1 triggered signals . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
However , neither the presence of proapoptotic Bax nor antiapoptotic Bcl 2 or Bcl XL affected tBid degradation . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bcl 2 , Bcl xL , Bad , Bak , and Bax levels were not altered by either treatment . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In contrast , Bcl 2 , Bcl 10 ( L ) , and Bax levels were not affected by bisindolylmaleimide . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Abundant pro apoptotic protein BAX and BCL 10 ( S ) were also observed . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We immunohistochemically examined the protein expression of Bcl 2 , Bcl XL , Mcl 1 , and Bax . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Expression of CD 95 , Bax , Bcl xL , and Bcl 2 proteins was determined by western blotting . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Under similar conditions , the addition of NGF resulted in a potent reduction in bax protein but not in Fas , or bcl xl . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Other members of the Bcl 2 family ( Bag 1 , Bak , Bax , and Bcl xL ) were not altered in expression . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Pro apoptotic proteins bax and Bcl 10 ( S ) were detectable in normal keratinocytes and 4 tumor cell lines . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Neither levels of Bax nor levels of Bcl XL were altered in diabetic neuropathy . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
These findings are correlated with modulations in bax , bcl 2 , bcl 10 ( L ) and p 21 protein levels . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Expression of Bcl 2 , Bcl 10 , and Bax proteins in cultured fibroblasts was studied by Western blotting . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
SAL treatment resulted in increased levels of Bax with a concomitant decrease in expression of Bcl 10 ( L ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
IL 10 decreased expression of bcl 2 , bcl 10 ( L ) , and mcl 1 but not bax mRNA in monocytes stimulated with GM CSF . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Targeted gene disruptions of p 53 and bax inhibited and bcl 10 potentiated chloroquine induced neuron death . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The expression of other members of the Bcl 2 family such as Bax , Bcl 10 ( L ) and Bak were not affected . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Ionizing radiation moderately enhanced expression of Bax , Bcl xL , and Cpp 32 proteins . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In contrast , fumonisin B ( 1 ) had no effect on expression of bcl 2 family genes ( bax , bcl 2 , and bcl 10 ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
No relationship was found between AI and labeling indices of Bcl 2 , Bcl 10 , Bax , p 53 , APO . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Concomitant deletion of the bax gene did not significantly modify the Bcl 10 phenotype . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Also , we have measured the levels of Bcl 2 , Bcl 10 , and Bax in 20 cases of T ALL . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The regulation of apoptosis by Bcl 2 , bcl 10 ( L ) , Bcl 2alpha and Bax in chronic liver disease ] . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Neither Bcl xL nor Bax expression were significantly modified by the carotenoid . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We observed no detectable changes in the steady state levels of Bcl 2 , Bcl 10 ( L ) , and Bax . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bcl 2 , Bcl 10 ( L ) , Bax and p 53 protein expression was revealed by Western blotting . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Changes in the apoptosis related proteins , bcl 2 , bcl xL , and bax were analyzed by Western blotting . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Both cell lines express almost the same levels of FADD , RIP , c FLIP , FAP 1 , Bax , Bcl 2 and Bcl XL . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The gene expression of Bax , Bcl 2 and Bcl xL was analysed by Northern blotting . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
With YCU N 861 cells , ATRA also caused a decrease in Bcl 2 and Bcl 10 ( L ) and an increase in Bax . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
There were no significant changes in the levels of Bcl xl , Bad , and Bax after heat exposure . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
High levels of BCL XL and low levels of BAX were independently linked to radioresistance . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
This channel forming activity requires an interaction between cut Bid and Bax , and is inhibited by Bcl 10 ( L ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The expression of Bax , Bcl 2 , Bak , and Bcl 10 ( L ) was analyzed by immunoblotting . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bim ( L ) , although unable to activate Bax , can directly inhibit Bcl 2 or Bcl 10 ( L ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The proteins studied were Bcl 2 , Bcl xL ( anti apoptotic ) , Bax , Bad , Bak , and Bcl xS ( pro apoptotic ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Corticosterone differentially regulates bax , bcl 2 and bcl 10 mRNA levels in the rat hippocampus . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Similarly , the levels of Bcl 2 , Bax and Bcl xL were unchanged in imexon treated cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Recombinant Bcl xL inhibited Cyt c release induced by tBID alone or in combination with monomeric BAX . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
PCP induced proapoptotic changes in Bax and Bcl 10 ( L ) were also prevented by M 40403 treatment . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
These proteins include the death antagonists Bcl 2 and Bcl 10 ( L ) , and death agonists Bax and Bad . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The PUMA protein interacts with Bcl 10 ( L ) and promotes mitochondrial translocation and multimerization of Bax . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bcl xL and intact Bax expression levels decreased when H2O2 was > 250 micro M . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
However , loss of Bax , Bak and Bcl Xs did not compromise sensitivity to TRAIL . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Western blot analysis was performed with anti ERK1 / 2 , Mcl 1 , Bak , Bcl 10 and Bax antibodies . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
No or only minor changes in Bcl 2 , Bcl XL and Bax levels were observed . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Under the same conditions GM CSF up regulated production of BAX as well as Bcl 2 , Bcl XL , survivin , and XIAP . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
All cell lines express high levels of cyclin E , c Myc , Bcl 2 , Bax , Bcl 10 ( L ) , and Mcl 1 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bcl 10 ( L ) expression prevents the release of mitochondrial Cytochrome c and apoptosis , but not Bax translocation . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
No changes were noted in the expression of mRNAs encoding Bcl 2 , Bcl xL , Bax , caspase 8 , caspase 3 , or GAPDH . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Increases of the antiapoptotic gene Bcl XL were counterbalanced by similar increases of the proapoptotic gene BAX . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bcl 2 and Bcl xL , but not DNC 8 , inhibited TRAIL induced Bax activation . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Moreover , Bcl 2 and Bcl xL protect neurons from apoptosis , while Bax and Bcl xS may act as proapototic proteins . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
METHODS : We performed Northern blot analysis for bax , bcl 10 ( L ) and bcl 2 at both temperatures . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
No change was detected in Bcl 2 , Bax , or Bcl xL proteins . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bax , a death promoting protein , was upregulated and Bcl 10 ( L ) , a death inhibiting protein , was downregulated . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bax and Bcl xL proteins were not changed , although Bcl 2 proteins increased with troglitazone . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Immunoprecipitation studies revealed that Nbk interacts with Bcl 10 ( L ) and Bcl 2 but not with Bax . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The proteasome inhibitor PS 341 overcomes TRAIL resistance in Bax and caspase 9 negative or Bcl xL overexpressing cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In contrast , Bcl 10 ( L ) protein bound and suppressed apoptosis induction by Bax , Bak and both BH 3 domain chimeras . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We also applied the RT PCR method to analyse Bax and Bcl xL gene expression . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
While Bcl 2 , Bcl 10 ( L , ) , and Bax were not affected , Mcl 1 was induced by IL 6 in human esophageal carcinoma cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Expression of Bcl 2 , Bcl xL , and Bax in JPX 9 cells was assessed with Western blot analysis . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Moreover , it reduced the expression of Bcl 2 and Bcl XL proteins , whereas it had no effect on the level of Bax protein . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Weak expression of other bcl 2 family member proteins , bax , bcl 2 and bcl xL , were also found in the immunoblots . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
There were no significant changes in Bcl 2 , Bcl xl , and Bax protein expression after troglitazone treatment . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Expression of Bax and Bcl Xs did not differ in cisplatin resistant and sensitive cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bcl 10 ( L , ) Bax , and Bak were expressed at similar levels in cardiac , dermal , and lung fibroblasts . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Expression of Bcl 2 mRNA and protein was down regulated , with no change in Bax or Bcl XL protein production . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
On the other hand , Bcl 10 ( L ) expression was decreased after T . vaginalis treatment accompanied with Bax activation . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The antiapoptotic Bcl 2 and Bcl xL proteins were downregulated , whereas the proapoptotic Bax was upregulated . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Furthermore , pro apoptotic Bax was overexpressed while anti apoptotic Bcl 2 and Bcl 10 ( L ) were suppressed . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In addition , Bcl 2 , Bcl xL , Bax , and Bak localized in the mitochondria were detected . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Both ASA and indomethacin reduced the protein levels of Bcl 2 and Bcl xl , but upregulated those of Bax and Bcl xs . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Suppression of COX 2 increased Bax protein and decreased Bcl 10 ( L ) protein in vitro . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The expression of Bcl 2 , Bcl xL and ICAD was reduced time dependently , whereas the expression of Bax was increased . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The increase in survival was associated with an increase in expression of mRNA of bcl xl but not bcl 2 and bax ex vivo . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
They reduced the expression of Bax and Bcl 2 proteins , but not Bcl 10 ( L ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Immunoblot analysis of Bax , Bcl 2 , Bcl xL , and caspase 9 were performed . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The levels of apoptosis related proteins Bcl 2 , Bax , and Bcl XL were not modulated by boswellic acid acetate . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In the heart , this cytosolic HSP 60 complexes with Bax , Bak and Bcl XL , but not with Bcl 2 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Western blotting was used further to detect the expression of apoptosis related protein Bcl xL / Bax . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Western blot analysis was used to examine the cellular effect of the expression of Bcl xL , Bax , and p 53 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
This was associated with upregulation of Fas and Bax and down regulation of Bcl xL in HSC . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NPD 1 also upregulates the anti apoptotic proteins Bcl 2 and Bcl xL and decreases pro apoptotic Bax and Bad expression . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In addition , the up regulation of bax , and the down regulation of bcl 2 and bcl xL , was observed . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
However , we did not observe any changes in Bcl 2 , Bcl XL , or Bax expression induced by COX 2 or PGE 2 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
All of the four mouse MM cell lines examined expressed Bax , Bcl xL , c Myc , and caspase 3 but not Bcl 2 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Furthermore , tBax efficiently induced death of the MG 63 cells overexpressing Bcl 10 ( L ) , compared with wt Bax . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In addition , palmitate treatment resulted in a significant decrease in Bcl 10 ( L ) , a Bax antagonist . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Renal function , structure , and immunohistochemistry for Bcl 2 , Bcl XL , and Bax were analyzed . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Justicidin A also reduced Bcl 10 ( L ) and increased Bax and Bak in mitochondria . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Matrine did not alter the level of bcl 2 and bcl xL as well as bax . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Expression of Bcl 2 , Bcl XL and Bax proteins was investigated using immunohistochemistry . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Similarly , the expression of bcl 2 , bcl 10 , bax and IL 1 beta converting enzyme did not correlate with susceptibility to anti IgM induced PCD . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bcl 2 and its relatives bcl 10 and bax encode intracellular membrane bound proteins that share homology in three domains with a wider family of viral and cellular proteins . ^^^ High levels of Bax or of a smaller Bcl 10 variant antagonize the survival function of Bcl 2 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bax also heterodimerizes with Bcl xL , Mcl 1 , and A 1 . ^^^ A Gly 159 > Ala substitution in BH 1 of Bcl xL disrupted its heterodimerization with Bax and abrogated its inhibition of apoptosis in mammalian cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Expression of Bcl 2 , Bcl 10 , and Bax after T cell activation and IL 2 withdrawal . ^^^ Bcl 2 , bcl 10 , and bax genes code for proteins that affect the susceptibility of cells to apoptosis . ^^^ In general , the expression of bcl 2 or bcl 10 inhibits apoptosis while bax promotes apoptosis . ^^^ Bcl 2 and Bax proteins vary coordinately , but Bcl 10 varies independently : Bcl 2 and Bax are higher in splenic T cells than in thymocytes , and their levels increase even more after T cell activation . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Immunoprecipitation indicated that Bcl xL , like Bcl 2 , heterodimerized with the death promoting molecule Bax in thymocytes . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Regulation of bcl 2 , bcl XL and bax in the control of apoptosis by hematopoietic cytokines and dexamethasone . ^^^ Treatment of M 1 myeloid leukemic cells with interleukin 6 ( IL 6 ) or dexamethasone ( DEX ) , both of which induce differentiation in these cells , down regulated expression of the apoptosis suppressing gene bcl 2 and the apoptosis promoting gene bax but up regulated expression of the apoptosis suppressing gene bcl XL . ^^^ Another myeloid leukemia that shows barely detectable expression of bcl 2 also showed up regulated expression of bcl XL but no change in bax after induction of differentiation with granulocyte macrophage colony stimulating factor , and this reduced cell susceptibility to induction of apoptosis by Adriamycin or cycloheximide . ^^^ The results indicate that the related apoptosis regulating genes bcl 2 , bcl XL , and bax are differently regulated and that up regulation of bcl XL expression may compensate for down regulation of bcl 2 in the balance between genes that control apoptosis . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
There are no cytokine related changes in Bcl 2 , Bax , or Bcl 10 protein levels that could account for the modulation of G 1 arrest versus apoptosis by growth factors . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We therefore propose a potential role of the novel bcl 2 gene family members bcl 10 and bax in surface IgM triggered apoptosis . . ^^^ Thus , we observed a much stronger expression of the death promoting proteins Bax alpha ( inducible ) and Bcl xs ( constitutive ) in sensitive cells than in resistant cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Herein we have characterized changes in the expression of the bcl 2 protooncogene ( an inhibitor of apoptosis ) , the bax gene ( an inducer of apoptosis ) , and the bcl 10 gene ( which encodes both bcl xlong , an inhibitor of apoptosis , and bcl xshort , an inducer of apoptosis ) during gonadotropin stimulated follicular development in vivo and during atresia of antral follicles incubated in vitro . ^^^ Complementary DNA fragments corresponding to rat bcl 2 , rat bax , and rat bcl 10 coding sequences were obtained by the reverse transcription polymerase chain reaction ( RT PCR ) technique using total RNA prepared from immature rat ovaries . ^^^ Northern blot analysis of steady state bcl 2 , bax , and bcl 10 messenger RNA ( mRNA ) levels in total RNA prepared from ovaries of immature rats before and after in vivo priming with 10 IU equine CG ( eCG ) revealed that eCG induced follicular growth and survival were associated with a relatively constitutive level of bcl 2 and bcl 10 expression but markedly reduced levels of bax mRNA ( 29 + / 5 % of saline treated control animals ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bad , a heterodimeric partner for Bcl XL and Bcl 2 , displaces Bax and promotes cell death . ^^^ Bad selectively dimerized with Bcl xL as well as Bcl 2 , but not with Bax , Bcl xs , Mcl 1 , A 1 , or itself . ^^^ When Bad dimerized with Bcl xL , Bax was displaced and apoptosis was restored . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Some members of the BCL 2 family ( bcl 2 alpha , bcl xL ) inhibit apoptosis , whereas some other ( Bax , Bclxs ) induce it . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We have previously demonstrated that the gonadotropin mediated inhibition of apoptosis in ovarian granulosa cells is linked to changes in the expression of several cell death related genes , including members of the bcl 2 gene family ( bcl 2 , bax , and bcl 10 ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We have studied the expression of the apoptosis regulating genes bcl 2 , bcl 10 , bax and APO 1 / fas ( CD 95 ) in human breast cancer . ^^^ We therefore propose that dysregulation of apoptosis contributes to the pathogenesis of breast cancer , at least in part , due to an imbalance between anti apoptosis genes ( such as bcl 2 / bcl 10 ) and apoptosis promoting genes ( bax ) . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Interactions of the Bcl 2 protein with itself and other members of the Bcl 2 family , including Bcl 10 L , Bcl 10 S , Mcl 1 , and Bax , were explored with a yeast two hybrid system . ^^^ Bcl 2 also interacted with Bcl 10 L and Mcl 1 and with the dominant inhibitors Bax and Bcl 10 S . ^^^ The findings suggest a model whereby Bax and Bcl 10 S differentially regulate Bcl 2 function , and indicate that requirements for Bcl 2 / Bax heterodimerization may be different from those for Bcl 2 / Bcl 2 homodimerization . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Sequence analysis of the BHRF 1 protein disclosed similarity with the recently described bcl 2 homologues bcl 10 ( 32 % ) and bax ( 34 % ) over the carboxyl portion , with several domains of complete identity . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Sequences similar to this domain were identified in Bax and Bip 1 , two other proteins that promote apoptosis and interact with Bcl xL , and were likewise critical for their capacity to kill cells and bind Bcl xL . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Here , we have investigated the possibility that the three recently identified Bcl 2 homologues , Bax , Bcl 10 , and Mcl 1 , could be involved instead . ^^^ Freshly isolated cells expressed both Bax and Mcl 1 protein , but only low levels of Bcl xL and no detectable Bcl xS , as determined by Western blot analysis . ^^^ Upon culture of cells with apoptotic or survival stimuli , Bax and Bcl xL protein levels remained relatively unchanged . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Immunoblot analysis of cellular expression of Bcl 2 family proteins , Bcl 2 , Bax , Bcl 10 and Mcl 1 , in human peripheral blood and lymphoid tissues . ^^^ Several homologues of the bcl 2 gene , such as bax , bcl 10 or mcl 1 , have recently been identified . ^^^ Like Bcl 2 , both Bcl XL and Mcl 1 appear to function as repressors of apoptotic cell death , whereas Bax facilitates it , indicating possible interactions among them in the control of cellular survival . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In mammalian cells , the Bcl 2 and Bcl 10 ( L ) proteins suppress programmed cell death whereas the topographically similar Bax protein accelerates the apoptotic process . ^^^ Recently published data suggest that expression of the human Bax alpha gene is lethal for the yeast Saccharomyces cerevisiae and that this toxicity can be overcome by co expressing Bcl 2 or Bcl 10 ( L ) . ^^^ Our results indicate that the process involving Bax induced growth inhibition followed by possible lethality , and the rescuing effect of Bcl 2 and Bcl 10 ( L ) is linked to yeast mitochondrial function . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Interleukin 2 receptor common gamma chain signaling cytokines regulate activated T cell apoptosis in response to growth factor withdrawal : selective induction of anti apoptotic ( bcl 2 , bcl xL ) but not pro apoptotic ( bax , bcl xS ) gene expression . ^^^ This rescue involves the induction of the anti apoptosis genes bcl 2 and bcl xL ) , but causes little change in expression of bax and bcl xS , which promote apoptosis . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
IGF 1 or insulin suppresses ICE mediated cell death without affecting the expression levels of Bcl 2 , Bcl 10 , or Bax . ^^^ Taken together , these results indicate that ICE is activated by growth factor deprivation , and IGF 1 is able to suppress ICE mediated cell death through a mechanism independent of the expression of Bcl 2 , Bcl 10 , or Bax . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Immunohistochemical analysis of bcl 2 , bax , bcl 10 , and mcl 1 expression in prostate cancers . ^^^ Using antibodies specific for the Bcl 2 , Bax , Bcl 10 , and Mcl 1 proteins in combination with immunohistochemical methods , we examined for the first time the expression of these bcl 2 family genes in 64 cases of adenocarcinoma of the prostate , including 10 Gleason grade 2 to 4 tumors , 21 grade 5 to 7 tumors , 17 grade 8 to 10 tumors , 8 lymph node metastases , and 8 bone metastases . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Taken together , these results suggest that expression of Bcl XL is increased in undifferentiated primary colorectal cancers , often with accompanying reciprocal decreases in the anti apoptotic proteins Bcl 2 and Mcl 1 and the pro apoptotic protein Bak , whereas Bax expression is relatively constant . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bcl 2 , Bcl 10 and Bax are members fo a family of cytoplasmic proteins that influence cell survival . ^^^ Whereas increased expression of Bcl 2 or Bcl 10 promotes cell survival following withdrawal of survival factors , increased expression of Bax is thought to suppress survival . ^^^ Surprisingly , overexpression of Bax rescued populations of sensory neurons deprived of nerve growth factor , as did overexpression of Bcl 2 and two Bcl 10 variants , Bcl XL and Bcl Xbeta . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bcl 10 ( L ) is able to increase the cellular apoptotic threshold and is able to form stable complexes with Bax both in vitro and in vivo . ^^^ However , compared with Bax , Bcl 10 ( S ) binds to Bcl 10 ( L ) weakly when assessed by in vitro binding assays . ^^^ In addition , overexpression of Bel 10 ( S ) does not alter the ability of Bax to heterodimerize with Bcl 10 ( L ) in vivo . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Mutant p 53 gene expression was detected in the majority of the cell lines and no relationship between p 53 gene expression and the expression of either bcl 2 , bcl 10 or bax was observed . ^^^ No changes in bcl 2 , bcl 10 and bax gene expression were observed in multidrug resistant cell lines compared with their drug sensitive counterparts . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The expression of a cell death inducing gene , Bax , was investigated in 52 cases of Hodgkin ' s disease in parallel with Epstein Barr virus and was compared with the immunodetection of other apoptosis regulating proteins , Mcl 1 , Bcl 2 , and Bcl 10 . ^^^ With the exception of 1 case , all Bax positive tumors also expressed either Bcl 2 , Bcl 10 , Mcl 1 , or combinations of these anti apoptotic proteins . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We report here that apoptosis induced by PMA , sphingosine , and N , N dimethylsphingosine ( DMS ) was accompanied by a concomitant decrease of bcl 2 expression in both RNA and protein levels in HL 60 cells , while expression of bcl XL and bax mRNA did not change , and neither sphingosine nor DMS induced differentiation of HL 60 cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Recent work also has revealed the existence of several bcl 2 related genes that also can inhibit ( e . g . , bcl 10 ( L ) and Mcl 1 ) or activate ( e . g . , bax , bcl 10 ( s ) , bag , and bad ) apoptosis in several systems . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
This protective effect of Bcl 2 occurs in the absence of significant variations , in the stimulated livers , in the level of expression of other proteins also involved in resistance or sensitivity to apoptosis , namely Bcl 10 , Bax , Bad , Bak , and p 53 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Association of bcl 2 , bax , bcl xL and interleukin 1 beta converting enzyme expression with initial response to chemotherapy in acute myeloid leukemia . ^^^ In this study we determined the role of bcl 2 to bax expression ratio , bcl xL and ICE expression level for predicting clinical response to chemotherapy in acute myelold leukemia ( AML ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The susceptibility of normal and cancer cells to induction of apoptosis is also regulated by the balance between apoptosis inducing genes such as the tumor suppressor wild type p 53 , and c myc and bax , and apoptosis suppressing genes such as the oncogene mutant p 53 , and bcl 2 and bcl XL . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The authors examined the expression of the apoptosis related modulators , Fas ( receptor ) , Fas ligand , Bax , Bcl 2 , Bcl XL , and interleukin 1 beta converting enzyme ( ICE ) in corneal cells as candidate mediators of this response and tested the effect of Fas receptor stimulating antibody on corneal stromal fibroblast cells in vitro . ^^^ METHODS : Reverse transcription polymerase chain reaction was used to detect FAS , FAS ligand , Bax , Bcl 2 , Bcl XL , and ICE mRNA expression in primary cultures of human corneal epithelial , stromal fibroblast , and endothelial cells . ^^^ RESULTS : FAS , Fas ligand , Bax , Bcl 2 , Bcl XL , and ICE mRNAs are expressed in all three major cell types of the cornea . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The expression of apoptosis regulating proteins , Bcl 2 , Bax , Mcl 1 , and Bcl 10 , was evaluated by immunohistochemical methods in 39 cases of thyroid carcinomas . ^^^ Normal thyroid tissues showed a consistent expression of Bcl 2 and Mcl 1 whereas Bax and Bcl 10 proteins were essentially absent from most follicular thyroid cells . ^^^ In particular , unlike normal thyroid epithelium , the apoptosis blocking gene bcl 10 and the apoptosis inducing gene bax are frequently expressed in thyroid carcinomas derived from the follicular cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The expression of the apoptosis regulating genes Bcl 2 , Bcl 10 , Bax , Mcl 1 , and p 53 analyzed in 4 cases of human immunodeficiency virus ( HIV ) associated Hodgkin ' s disease , in 36 cases of HIV related non Hodgkin ' s lymphomas ( NHLs ) , and in 109 cases of non HIV related NHLs by using immunohistochemistry . ^^^ For the HIV related NHL samples , 36 , 66 , 88 , 100 , and 94 % of the cases were Bcl 2 , Bcl 10 , Bax , Mcl 1 , and p 53 were found to be expressed in 69 , 65 , 82 , 83 , and 42 % , respectively . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
IR upregulated p 53 and p21WAF1 about 5 to 10 fold and downregulated bcl 2 and bcl XL by 80 90 % at 6 hr in both parent and bax stably transfected MCF 7 cells to the same degree . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The gamma IFN dependent protection was due neither to down regulation of p 53 , nor to the p 53 induced genes , p 21 ( WAF 1 ) and bax , nor to up regulation of bcl 2 or bcl xL . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The results show that : ( 1 ) As2O3 triggers relatively specific NB 4 cell apoptosis at micromolar concentration , as proved by morphology , histogramic related nuclear DNA contents , and DNA gel eletrophoresis . ( 2 ) As2O3 does not influence bax , bcl 10 , c myc , and p 53 gene expression , but downregulates bcl 2 gene expression at both mRNA and protein levels . ( 3 ) As2O3 induces a significant modulation of the PML staining pattern in NB 4 cells and HL 60 cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
These results indicate that radiation elicited apoptosis of fetal brain cells is associated with activation of the p 53 system , probable increases in AP 1 Fos / JunB heterodimers , and an increased ratio of Bax to Bcl 2 + Bcl xL . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Intense cytoplasmic immunostaining for pro apoptotic Bax protein and moderate immunolabeling for Bcl 10 was observed in the epithelium of the choroid plexus of the lateral and third ventricles . ^^^ However , constitutive expression of Bax and Bcl 10 proteins in the plexus choroideus did not change significantly following focal ischemia . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Fas , Bcl 2 family ( Bcl 2 , Bcl 10 and Bax ) and ICE family ( ICE , Ich 1 ) were found to be involved in tumorigenesis of certain brain tumors . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Thus , like Bcl 2 and Bcl 10 , the Bcl w protein promotes cell survival , in contrast to other close homologues , Bax and Bak , which facilitate cell death . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In this report , we examined the levels of expression of proteins that can either prevent apoptosis ( i . e . , Bcl 2 or the long form of Bcl 10 , designated Bcl x 1 ) or promote apoptosis ( i . e . , Bax or the short form of Bcl 10 , designated Bcl xs ) in proliferating benign and malignant endothelial cells ( ECs ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
When HCD 57 cells were cultured in the absence of Epo , Bcl 2 and Bcl XL but not Bax were downregulated , and the cells underwent apoptotic cell death . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Despite the down regulation of bcl 2 in MCF 7 / Adr cells and equal levels of bcl 10 , and bax proteins in both cell lines , cytoplasmic DNA histone complexes induced by doxorubucin , taxol , vincristine and VP 16 indicate that MCF 7 / Adr cells are highly resistant to apoptosis . ^^^ Down regulation of apoptosis related bcl 2 but not bcl xL or bax proteins in multidrug resistant MCF 7 / Adr human breast cancer cells . ^^^ Recent studies have shown that high levels of the apoptosis related proteins bcl 2 and bcl xL increase , while over expression of bcl xs or bax decreases , resistance to drugs that induce apoptosis in some human cancer cells . ^^^ In this study , high levels of bcl xL and bax proteins are detected in both MCF 7 and MCF 7 / Adr cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Apoptosis in Tag mice was associated with increased steady state RNA levels of bax and bcl xL + S , with a relative increase in bcl xs expression . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In addition , the absence of functional p 53 did not alter the involution related pattern of bax ( death inducer ) gene expression or the ratio of RNAs encoding bcl xs ( death inducer ) to bcl xL ( survival inducer ) . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bax and Bcl xs are induced at the onset of apoptosis in involuting mammary epithelial cells . ^^^ These findings point to a significant role for Bax and Bcl xS in the regulation of apoptosis of secretory alveolar cells during involution . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The proto oncogene bcl 2 and its family members , bcl 10 and bax are recognized as major regulators of cell death and survival . ^^^ Here we have studied the expression of bcl 2 , bcl xL and bax mRNA in rat cerebellar granule neurons cultured under conditions which influence neuron survival . ^^^ Insulin like growth factor 1 and brain derived neurotrophic factor supported the survival of these neurons , but affected neither the expression of bcl 2 , bcl xL nor bax mRNA . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The pattern of expression of Bcl 2 , Bcl xL , Bcl xS and Bax genes , selected because of their interrelated role in the control of apoptosis , was analysed in a series of CD5+ B cell chronic lymphoid leukaemias . ^^^ According to the functional role of Bcl 2 , Bcl xL , Bcl xS and Bax , these data indicate that the pattern of Bcl 2 family genes expression in leukaemic CD5+ B cells is skewed toward prevention of apoptosis and may thus favour the relentless accumulation of CD5+ leukaemic B cells . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Localization of bcl 2 , bax , and bcl 10 mRNAs in the developing inner ear of the mouse . ^^^ In situ hybridization was employed to study the expression of bcl 2 mRNA and its family members , bax and bcl 10 mRNAs , in the developing inner ear . ^^^ We found that in the cochlear structure , sensory epithelial cells , the spiral ganglion and stria vascularis expressed these mRNAs in postnatal period in a temporally similar manner , but in embryos , neither bax nor bcl 10 mRNA were expressed in the sensory epithelium from embryonic day ( E ) 13 to 19 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In mouse mammary tumors , the relative Bcl xL / Bax ratio was higher in TGF alpha / Myc double transgenics than in Myc single transgenics , in agreement with the in vitro data . ^^^ Northern and Western analysis revealed high levels of Bax and p 53 , and low or undetectable levels of Bcl 2 and Bcl xS under all treatment condition . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We examined the expression of Fas and bcl 2 family gene products , such as Bcl 2 , Bcl 10 , Bax , and Mcl 1 , in human tonsillar B cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Altered expression of Bcl 2 , Bcl 10 , Bax , and c Fos colocalizes with DNA fragmentation and ischemic cell damage following middle cerebral artery occlusion in rats . ^^^ A decrease in immunoreactivity for Bcl 2 , and Bcl 10 and an increase in immunostaining for Bax was observed exclusively in neurons within the ischemic cortex and thalamus . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Factors that influence activated CD8+ T cell apoptosis in patients with acute herpesvirus infections : loss of costimulatory molecules CD 28 , CD 5 and CD 6 but relative maintenance of Bax and Bcl 10 expression . ^^^ This spontaneous cell death could be prevented by interleukin 2 ( IL 2 ) and was related to a decreased expression of Bcl 2 but not Bax or Bcl XL , additional molecules that promote or prevent apoptosis , respectively , as well as an increase in CD 95 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
As compared to HL 60 / neo , HL 60 / Bcl 2 cells contained significantly higher ( approximately 10 fold ) p26Bcl 2 , but equivalent levels of Bax and undetectable levels of Bcl xL . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The Bcl 2 related genes , Bax and Bcl2l ( formerly called Bclx ) , are involved in the regulation of apoptotic cell death , and the chromosome location of these two genes was determined in the mouse and rat by fluorescence in situ hybridization . ^^^ Chromosomal assignment of the Bcl 2 related genes , Bcl2l and Bax , in the mouse and rat . ^^^ Bcl2l was localized to mouse chromosome 2H1 and rat chromosome 3q41 . 2 , and Bax was localized to mouse chromosome 7B5 and rat chromosome 1q31 . 2 . ^^^ Molecular linkage analysis using interspecific backcross mice revealed the murine Bcl2l locus at 0 . 7 cM terminal to D2Mit22 , and the murine Bax locus at 0 . 8 cM terminal to D7Nds5 . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The apoptosis regulating proteins Bcl 2 , Bax , Bcl 10 , Bak , and Mcl 1 were examined by immunohistochemical methods in 48 archival specimens of adenocarcinoma of the stomach , and the results were correlated with tumor histology ( intestinal versus diffuse pattern ) and clinical stage ( early versus late stage disease , ie , stages 1 and 2 versus stage 3 ) . ^^^ Tumor cells containing immunostaining for the anti apoptotic proteins Bcl 2 , Bcl 10 , and Mcl 1 were present in 26 ( 54 % ) , 41 ( 85 % ) , and 36 ( 75 % ) of the 48 cases evaluated , respectively , whereas immunopositivity for the pro apoptotic proteins Bax and Bak was found in 44 ( 92 % ) and 42 ( 88 % ) specimens Comparisons of these immunostaining results with tumor histology revealed statistically significant differences for Bax ( P = 0 . 03 ) , Bcl 10 ( P = 0 . 003 ) , and Mcl 1 ( P = 0 . 005 ) , which were all more frequently immunopositive for tumors with an intestinal than a diffuse histological pattern ( chi 2 analysis ) . ^^^ The immunointensity for the Bcl 2 , Bcl 10 , and Mcl 1 proteins was stronger in tumor cells compared with normal foveolar cells in 7 ( 21 % ) , 15 ( 44 % ) , and 8 ( 2 . 1 % ) of 34 cases , respectively , whereas the immunointensity of the proapoptotic proteins Bax and Bak was reduced compared with normal cells in 8 ( 24 % ) and 24 ( 71 % ) cases . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Messenger RNA ( mRNA ) expression of bcl 2 , bcl 10 , bax , and c myc in T and B cells was determined by enzyme linked immunosorbent assay polymerase chain reaction ( ELISA PCR ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Using in situ hybridization , Northern blotting and RT PCR we studied the post ischemic expression of bcl 2 , bcl 10 , bax and ICE . ^^^ One day following 5 min or 10 min of global ischemia bcl 2 and bcl 10 mRNAs were induced in CA 1 hippocampal pyramidal neurons while bax was unchanged . ^^^ By 72 h after ischemia the expression of bcl 2 , bcl 10 and bax mRNAs decreased in CA 1 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
This multigene family of cell death regulators includes members which enhance rates of apoptosis , including bcl xs and bax , and those which inhibit apoptosis , including MCL 1 and bcl xL . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Immunoblotting revealed that BAX transfectants expressed a mean of 10 fold increased levels of BAX compared with neo transfected control clones , with similar levels of BCL 2 and BCL xL . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Since the discovery of Bcl 2 a decade ago , several other cellular and viral genes encoding homologous proteins have been identified , some of which suppress cell death akin to Bcl 2 ( Bcl XL , Mcl 1 , A1 / Bfl 1 , Nr 13 , Ced 9 , BHRF 1 ) and others which promote apoptosis ( Bax , Bcl Xs , Bak , Bik , Bad ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
All lines showed constitutive expression of bcl 2 and bcl XL ( the suppressors of apoptosis ) with low and non inducible levels of bax ( a promoter of apoptosis ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
This effect is achieved in the absence of any detectable changes in the levels of BCL 2 , BAX or BCL 10 proteins and is independent of proliferative , MAP kinase dependent effects of BCR ABL kinase . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Like BAX , another member of the BCL 2 family and a p 53 regulated gene , the induction of BCL 10 ( L ) was dependent on normal p 53 function and required that cells have an apoptosis susceptible phenotype . ^^^ We speculate that the physiological function of increased BCL 10 ( L ) protein would be expected to probably limit the severity and length of BAX effect in order to maintain a proper threshold for apoptosis and to complete cell cycle arrest activated by p53 . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Expression pattern of candidate cell death effector proteins Bax , Bcl 2 , Bcl 10 , and c Jun in sensory and motor neurons following sciatic nerve transection in the rat . ^^^ In the L 5 dorsal root ganglia ( DRG ) levels of Bax , Bcl 2 , and Bcl 10 proteins were highly variable . ^^^ It should be noted , however , that numerous strongly Jun positive DRG neurons contained low levels of Bax or high levels of Bcl 2 and Bcl 10 immunoreactivity . ^^^ These findings indicate that the high susceptibility of central neurons and small sized DRG neurons to axotomy induced cell death might be related to their low ratio of cell death repressor Bcl 2 and Bcl XL to cell death promotor Bax expression . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In contrast , both cell types expressed equivalent levels of Bcl xL , Bax , Bcl 2 , Myc , retinoblastoma , p21cbor abl , and p145abl proteins . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Modulation of apoptosis associated genes bcl 2 , bcl 10 , and bax during rat liver regeneration . ^^^ Western blot analyses of Bcl 2 and Bcl 10 proteins showed no significant change through 96 h of LR , whereas Bax protein levels cycled in parallel with its mRNA . ^^^ When liver growth was induced by the peroxisome proliferator clofibrate , transcript and protein levels were coupled for bcl 10 but not for bax . ^^^ In conclusion , the apoptosis associated genes bcl 2 , bcl 10 and bax are modulated at the transcript and protein levels during LR , suggesting a role for these gene products in normal liver growth . ^^^ Furthermore , unlike bax , steady state protein and transcript levels are uncoupled for both bcl 2 and bcl 10 , suggesting a role for translational regulation during LR after PH . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Apoptosis resistance in the metastatic cells was associated with higher levels of expression of the cell death suppressor BCL 2 and lower levels of the death promoters BAX and BAK than were detected in the nonmetastatic LNCaP Pro 5 cells , whereas levels of two other BCL 2 family members ( BCL 10 ( L ) and BAD ) were indistinguishable . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In the nervous system , genes have been identified which either 1 ) promote apoptosis : Bax , Bcl xS , c fos , c jun , p75NGFR and ICE like proteases , or 2 ) block apoptosis : Bcl 2 and Bcl xL . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
This effect of IFN alpha 2 was neither explained by a down regulation of the Apo 1 / Fas receptor nor caused by modulation of the expression levels of c myc , bcl 2 , bcl xL , bax or p 53 genes . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The pro apoptotic protein bax was expressed at lower levels in carcinomas than in adenomas , whereas bak and bclx were expressed in the same order of magnitude in all tissues examined . ^^^ In all four cell lines , the amounts of the pro apoptotic proteins bax , bak and bclx were higher than in most tumor tissues . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Expression of wild type p 53 stimulates an increase in both Bax and Bcl xL protein content in HT 29 cells . ^^^ We show here that when wild type p 53 activity is expressed in HT 29 human colon cancer cells by use of a temperature sensitive p 53 mutant , Bax levels rise , but so do levels of Bcl xL protein . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Partial cDNA clones encoding bovine bax , bcl 10 , p 53 , and Ice were isolated using the reverse transcriptase polymerase chain reaction ( RT PCR ) technique with total RNA prepared from functional or regressed CL . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bax alpha can heterodimerize with Bcl 2 and Bcl 10 ( L ) , countering their effects , as well as promoting apoptosis on overexpression . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Overexpression of P glycoprotein ( PGP ) , MRP or LRP has been characterized as the ' proximal ' , while overexpression of the anti apoptosis Bcl 2 or Bcl xL relative to the pro apoptosis Bax protein has been recognized as the ' distal ' mechanism of multidrug resistance in human AML cells . ^^^ For this , immunoblot analyses were performed to determine the expression of PGP , MRP , Myc , Bcl 2 , Bcl xL and Bax on either the multidrug resistant HL 60 sublines created under the selection pressure of doxorubicin ( HL 60 / AR ) , paclitaxel ( HL 60 / TAX1000 ) or vincristine ( HL 60 / VCR ) , or sublines created by transfection and overexpression of the bcl 2 ( HL 60 / Bcl 2 ) or bcl xL gene ( HL 60 / Bcl xL ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Analysis of oncogenes regulating apoptotic cell death revealed a marked decrease of bcl 2 in combination with a moderate reduction of bax protein , but a striking overexpression of the long form of the bcl 10 protein . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The process o apoptosis in keratinocytes was dissected at the molecular level and found to be correlated with increased expression of Bax and decreased levels of Bcl XL , with no role for either Bcl 2 or Bcl XS . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Immunohistochemical examination of the expression of the apoptotic checkpoint proteins , Bcl 10 , Bax and Bcl 2 , demonstrated that they are expressed in the terminal endbud . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We report here on the high detection rate of the Bcl 10 protein found in 86 % of Hodgkin ' s disease samples and on the significance regarding its complex role among the Bcl 2 family of proteins : Bcl 10 is known to heterodimerize with Bcl 2 ( an anti apoptosis protein ) and with Bax , a potent inducer of cell death . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The possibility also exists that inducers of apoptosis , e . g . tumor necrosis factor ( TNF ) , interleukin 1 beta converting enzyme ( ICE ) , Bcl xS , or Bax , do not have a lethal effect . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In order to determine whether the process of programmed cell death is distinct between cord blood and peripheral blood lymphocytes , we analyzed the expression of fas and bax ( apoptosis promoting genes ) and bcl 2 and bcl xL ( apoptosis inhibiting genes ) at protein or mRNA levels using flow cytometry and quantitative PCR methods , respectively . ^^^ We observed that cord blood T cell subsets expressed lower levels of Fas and Bcl 2 , a low bcl 2 / bax ratio , and higher bcl xL compared to peripheral blood . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Immunohistochemical analysis of Bcl 2 , Bcl 10 , Mcl 1 , and Bax in tumors of central and peripheral nervous system origin . ^^^ The expression of Bcl 2 , Bcl 10 , Mcl 1 , and Bax was examined by immunohistochemical methods in 93 tumors of nervous system origin , including 49 gliomas ( 30 astrocytomas and 19 glioblastoma multiforme ( GMs ) ) , 16 medulloblastomas ( MBs ) , 19 neuroblastomas ( NBs ; 9 undifferentiated and 10 differentiated ) , and 9 miscellaneous neuroectodermal neoplasms . ^^^ Among the 49 gliomas , immunopositivity ( defined as > or = 10 % ) was observed for Bcl 2 in 45 ( 92 % ) , Bcl 10 in 48 ( 98 % ) , Mcl 1 in 49 ( 100 % ) , and Bax in 48 ( 98 % ) of 49 specimens . ^^^ Of the 16 MBs , immunopositivity was found for Bcl 2 in 4 ( 25 % ) , Bcl 10 in 9 ( 56 % ) , Mcl 1 in 8 ( 50 % ) , and Bax in 16 ( 100 % ) of the cases . ^^^ The intensity of immunostaining was strong for Bcl 2 in only 1 ( 6 % ) specimen , for Bcl 10 in 3 ( 19 % ) , and for Mcl 1 in 2 ( 12 . 5 % ) , in contrast to Bax immunostaining , which was strong in 12 ( 75 % ) tumors . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In the present studies , we demonstrate that in human AML HL 60 cells that express Bcl 2 but little Bcl xL ( HL 60 / neo cells ) , paclitaxel induced phosphorylation of Bcl 2 is followed by increased intracellular free Bax levels . ^^^ Immunoprecipitation studies with anti Bcl 2 and / or anti Bcl 10 antibodies demonstrated that HL 60 / Bcl xL cells possess lower free Bax but higher levels of Bax heterodimerized to Bcl 2 and Bcl xL . ^^^ Following treatment of HL 60 / Bcl xL cells with paclitaxel , although Bcl 2 phosphorylation was observed , it was not followed by increased free Bax levels , cleavage of CPP32beta / Yama and poly ( ADP ribose ) polymerase , or induction of the DNA fragmentation of apoptosis . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bax deficiency prevents the increased cell death of immature neurons in bcl 10 deficient mice . ^^^ Targeted disruption of bcl 10 , a death repressing member , causes massive cell death of immature neurons in the developing mouse CNS , whereas targeted disruption of bax , a proapoptotic member , blocks the death of specific populations of sympathetic and motor neurons . ^^^ In the present study , mice deficient in both Bcl xL and Bax ( bcl 10 / / bax / ) are used to examine the relative significance and potential interactions of Bcl xL and Bax during early CNS development . bcl 10 / / bax / mice demonstrate greatly reduced levels of apoptosis both in vivo and in vitro compared with the CNS of Bcl xL deficient mice , as assessed by histology and terminal deoxytransferase mediated deoxyuridine triphosphate nick end labeling . ^^^ These results suggest that Bax critically interacts with Bcl xL to regulate survival of immature neurons , but indicate that other cell death regulating proteins , in addition to Bcl xL and Bax , also function during CNS development . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bax activation in 6 hydroxydopamine induced apoptosis in PC 12 cells . p 53 , Bax and Bcl xL proteins have been implicated in apoptotic neuronal cell death . ^^^ Up regulation of p 53 and Bax proteins was demonstrated 4 and 6 h , respectively , after 6 OHDA treatment ; in contrast , no change in Bcl xL levels was found . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Neonatal diethylstilbestrol treatment alters the estrogen regulated expression of both cell proliferation and apoptosis related proto oncogenes ( c jun , c fos , c myc , bax , bcl 2 , and bcl 10 ) in the hamster uterus . ^^^ As part of a project to investigate the molecular and cellular mechanisms responsible for this phenomenon , expression of several proto oncogenes ( c jun , c fos , c myc , bax , bcl 2 and bcl 10 ) was compared in estrogen stimulated uteri from control versus neonatally DES treated hamsters . ^^^ However , the 1 . 0 kb bax and 2 . 7 kb bcl 10 transcript levels were significantly increased in the neonatally DES exposed uteri . ^^^ According to immunohistochemical analysis of paraformaldehyde fixed and paraffin embedded tissue sections , levels of c Jun , c Fos , c Myc , Bax , and Bcl 10 proteins were enhanced dramatically in both the luminal and glandular epithelial cells of neonatally DES exposed uteri . ^^^ In conclusion , neonatal DES treatment induced persistent and epithelial cell specific imbalances in the estrogen regulated uterine expression of c jun , c fos , c myc , bax , bcl 2 , and bcl 10 proto oncogenes . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
ET 18 OCH 3 did not affect the expression of bcl 2 , bcl xL , or bax in HEL and HL 60 human leukemic cells but induced expression of c myc , an important effector of apoptosis in several systems . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The Bcl 2 and Bcl 10 proteins suppress programmed cell death , whereas Bax promotes apoptosis . ^^^ We investigated the pattern of expression of Bcl 2 , Bax and Bcl 10 during neuronal differentiation and development . ^^^ All three proteins were widely expressed in neonatal rats but , in the adult , Bax levels were 20 to 140 fold lower in the cerebral cortex , cerebellum and heart muscle , whereas Bcl 10 was not downregulated in any of the tissues examined . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Experiments using transgenic and gene knockout mice have revealed much about the roles played by Bcl 2 , Bcl 10 and Bax in regulating apoptosis in the immune system . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Cytosol to membrane redistribution of Bax and Bcl 10 ( L ) during apoptosis . ^^^ Bcl 2 , Bcl 10 ( L ) , and Bax are members of the Bcl 2 family that play key roles in the regulation of apoptosis . ^^^ Herein we report that in murine thymocytes , Bcl 2 is exclusively membrane bound , whereas Bax is present predominantly in the cytosol and Bcl 10 ( L ) is present in both soluble and membrane bound forms . ^^^ Induction of apoptosis in murine thymocytes by dexamethasone or gamma irradiation shifts the subcellular locations of Bax and Bcl 10 ( L ) from soluble to membrane bound forms . ^^^ Inhibition of apoptosis with cycloheximide inhibits the movement of Bax and Bcl 10 ( L ) in thymocytes from the cytosol into membranes induced by dexamethasone treatment . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Expression and regulation of Bcl 2 , Bcl xl , and Bax correlate with p 53 status and sensitivity to apoptosis in childhood acute lymphoblastic leukemia . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Similar assays demonstrate that Bcl xL can form both homodimers and heterodimers and that these interactions are also inhibited by Bax and the BH 3 derived peptides . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
As the low level of bcl 2 and bax mRNA was not influenced by progesterone treatment , the observed changes in total amount of bcl 10 transcripts and spliced isoforms could represent the mechanism by which progesterone controls cell death in epithelial cells of the endometrium . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Ten erythema multiforme and five control oral mucosa biopsy specimens were evaluated in immunohistochemically stained sections for apoptosis regulating proteins Bcl 2 , Bcl 10 , Bax , p 53 , Fas , and Fas ligand . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bcl 2 and its homologues , bcl 10 and bax , also increase in amount with bcl 2 and bcl 10 increasing more rapidly than bax . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The product of harakiri , Hrk , physically interacts with the death repressor proteins Bcl 2 and Bcl 10 ( L ) , but not with death promoting homologs , Bax or Bak . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In this study , we examined the sphingosine induced apoptosis of the androgen independent human prostatic carcinoma cell line DU 145 , which expresses bcl 10 ( L ) and Bax but not bcl 2 , and found that treatment of DU 145 cells with sphingosine suppressed bcl 10 ( L ) in both mRNA and protein levels but did not change bax expression at all . ^^^ In contrast , in apoptotic cells treated with a PKC inhibitor , staurosporine , no effect on bcl 10 ( L ) or bax expression was observed . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Members of the Bcl 2 family ( including Bcl 2 , Bcl XL , and Bax ) play key roles in the regulation of apoptosis . ^^^ We have found that whereas Bcl 2 is predominantly membrane associated as previously reported , significant amounts of Bcl XL and most of the Bax proteins are not membrane associated and thus appear in the cytosolic fraction of thymocyte and splenocyte extracts . ^^^ For this analysis , we have produced monoclonal antibodies that are specific for known epitopes of Bax , Bcl 2 , and Bcl XL . ^^^ In the presence of nonionic detergent , the 6A7 antibody avidly binds the monomeric form of Bax , but not Bax complexed with either Bcl XL or Bcl 2 . ^^^ Bcl XL or the Bax . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Denervated muscle fibres revealed strong immunoreactivity of the anti apoptotic proteins bcl 2 and bcl xL , and the pro apoptotic factor bax . ^^^ In reinnervated muscle fibres , only bcl 2 was constantly upregulated while bcl xL and bax diminished after the 7th week . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
IGF induced protection against dexamethasone was not associated with any alteration in quantitative or qualitative expression of BCL 2 , BAX or BCL 10 proteins . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bcl 2 , Bcl 10 , Bax and p 53 apoptosis associated proteins were evaluated in immunohistochemically stained tissue sections according to staining intensity and pattern . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The Bcl 10 ( S ) levels were increased rapidly after treatment with all of these agents , whereas the levels of Bcl 10 ( L ) and Bax remained largely unchanged . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The three pro apoptotic members of the family , Bak , Bad , and Bax , all showed an early decline in mRNA levels when Bcl 10 transcripts increased , followed by later peaks at 12 , 24 , and 48 to 72 hours , respectively . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Using western blotting and immunochemical analysis , we investigated alterations in the expression of the apoptosis related proteins bcl 2 , bax , and bcl 10 in colonic adenocarcinomas induced by subcutaneous injection of azoxymethane ( AOM ) ( 15 mg / kg body weight weekly for 2 wk ) into male Sprague Dawley rats . ^^^ As determined by immunohistochemical analysis , the tumor cells had more bax and bcl 10 protein . ^^^ Expression of bcl 2 , bax , and bcl XL proteins in azoxymethane induced rat colonic adenocarcinomas . ^^^ The expression of bax protein , an apoptosis accelerator , was significantly stronger ( 7 . 33 fold ) in all the tumors than in the non tumoral mucosa . bcl XL protein , which functions as a repressor of apoptosis , was significantly upregulated ( 3 . 23 fold ) in all the tumors when compared with the non neoplastic mucosa . ^^^ These findings indicate that the regulation of the apoptosis related proteins bcl 2 , bax , and bcl XL was altered in the AOM induced colonic neoplastic tissue . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bax / Bak lethality was suppressed by coexpression of Bcl 2 family members that are anti apoptotic in vertebrates , namely Bcl xL , Bcl 2 , Mcl 1 , and A 1 . ^^^ Furthermore , Bcl xL and Bcl 2 suppressed Bax toxicity by distinct mechanisms in yeast . ^^^ However , two mutants of Bcl xL suppressed Bax induced cell death while having no Bax binding activity . ^^^ Therefore , Bcl xL functions independently of Bax binding , perhaps by interacting with a common target or promoting a pathway that antagonizes Bax . ^^^ Thus , the pathways downstream of Bax and Bcl xL may be conserved between vertebrates and yeast . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
To investigate the dual effects ( proliferation and apoptosis ) of IL 10 on B cells , the expression of a panel of bcl 2 protoncogene family members , bcl 2 , bcl 10 , mcl 1 , and bax , was analyzed when B cells were activated by SAC . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Preablation biopsy specimens and prostatectomy specimens were immunohistochemically stained for apoptotic cells and for expression of apoptosis regulatory proteins Bcl 2 , Bax , Bcl 10 , and Bak . ^^^ In all 26 specimens , benign prostatic hyperplasia demonstrated increased expression of the Bcl 2 protein , but no change in the expression of Bax , Bcl 10 , and Bak . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Cells growing attached to flasks appear to be relatively more resistant than suspension growing cells in spite of endogenous bcl 2 , bax , or bcl 10 levels . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The effects of the expression of the human Bcl 2 family proteins Bax , Bak , Bcl 2 , and Bcl XL were examined in the fission yeast Schizosaccharomyces pombe and compared with Bax induced cell death in mammalian cells . ^^^ Expression of the proapoptotic proteins Bax and Bak conferred a lethal phenotype in this yeast , which was strongly suppressed by coexpression of the anti apoptotic protein Bcl XL . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
On mRNA or protein levels induction of pro and anti apoptotic gene products like fasL , bcl 2 , or bax with minor effects on fas / Apo 1 or bcl XL was observed under culture conditions with both IL 2 and IL 15 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Previous work has shown that the death inhibiting family members Bcl 2 and Bcl xL form heterodimers with the death promoting homologue Bax and that certain site directed mutants of Bcl 2 and Bcl xL lose both biological activity and the ability to bind Bax . ^^^ To better understand the structural basis of heterodimer formation , we have used a yeast two hybrid assay to screen for mutants of Bax that regain the ability to bind to these inactive Bcl 2 ( G145A ) and Bcl xL ( G138A ) mutants . ^^^ These results indicate that while the Bcl 2 and Bcl xL mutants fail to bind full length Bax , they still retain a binding site for the critical BH 3 domain . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Since phosphorylation / dephosphorylation reactions have been suggested to be involved in the regulation of Bcl 2 , we planned to investigate whether the expression of Bcl 2 , Bcl 10 ( L ) and Bax , a protein that antagonizes the antiapoptotic function of Bcl 2 , are regulated in myeloid leukemia cell lines ( K 562 , KU 812 and HL 60 ) treated with okadaic acid . ^^^ Our results indicate that exposure of all three leukemic cell lines to nanomolar concentrations of okadaic acid causes a loss of viability by activation of an apoptotic process accompanied by a marked decrease in the expression of Bcl 2 , Bcl 10 ( L ) and Bax at both mRNA and protein level , but not of c fos , vimentin and epsilon globin , ruling out a non specific effect of okadaic acid . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Analysis of bi transgenic K rasVal 12 10 TAgWt mice homozygous for wild type or null p 53 alleles established that the enhancement of apoptosis occurs through a p 53 independent mechanism , is not attributable to augmented proliferation or to an increase in abortive cell cycle reentry ( compared to TAgWt mice ) , and is not associated with detectable changes in the crypt villus patterns of expression of apoptotic regulators ( Bcl 2 , Bcl xL , Bak , and Bax ) or mediators of epithelial cell matrix interactions and survival ( e . g . , alpha5beta1 integrin and its ligand , fibronectin ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
To further understand the underlying mechanism ( s ) for these findings as they relate to gene directed neural cell death , we studied the in situ expression of the Bcl 2 family of proteins , including the pro apoptosis gene product Bax , the anti apoptosis gene product Bcl 2 , and Bcl 10 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Expression of Bcl 10 ( an antiapoptotic Bcl 2 family protein ) was not altered by bile duct ligation , whereas expression of Bax ( a proapoptotic Bcl 2 family protein ) increased slightly as determined by Northern and Western blot analyses . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bcl xL and bax are bcl 2 related genes whose protein products either inhibit or promote apoptosis . ^^^ The ability of the Bcl proteins to affect GSH was assessed in control , bax and bcl xL transfected FL5 . 12 cells [ an interleukin ( IL ) 3 dependent murine prolymphocytic cell line ] . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Expression of the BCL 2 protein family members , BAX , BAK , BAD , BCL xL , BCL xS , and BCL 2 , was measured ( by western blotting using specific antibodies ) in PC 12 cells before and during apoptosis induced by either H2O2 treatment or by serum deprivation and during rescue from apoptosis by nerve growth factor ( NGF ) . ^^^ Our results show that the expression of BAX , BAK , BAD , and BCL xL is altered in a stimulus dependent manner but can not be used to define whether a cell will undergo or survive apoptosis . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
High levels of the antiapoptotic Bcl 10 ( L ) or Bcl 2 , relative to the proapoptotic Bax , have been shown to inhibit HIDAC induced cleavage and activity of caspase 3 and apoptosis of the human acute myeloid leukemia HL 60 cells . ^^^ In a previous report , we demonstrated this inhibition , using the control HL 60 ( HL 60 / neo ) cells and their counterparts , HL 60 / Bcl 10 ( L ) , which have enforced overexpression of Bcl 10 ( L ) and a significantly lower ratio of free to bound Bax . ^^^ HIDAC treatment for 4 h also modestly increased the intracellular levels of free Bax relative to Bax bound to Bcl 2 and Bcl 10 ( L ) in HL 60 / neo but not in HL 60 / Bcl 10 ( L ) cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Remarkably , reentry of villus enterocytes to the cell cycle increases the radiosensitivity of the crypt epithelium without changing Bcl 2 , Bcl xL , Bak , or Bax expression . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
To better understand the regulation of apoptosis in this paradigm of endocrine regulated cell turnover , we studied the expression of the cell death regulatory genes , bax , bcl 2 , and bcl 10 , in human proliferative and secretory endometria relative to the absence or presence of apoptosis . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The expression of cell cycle genes including cyclin A , C , D 1 , E , cdk 2 , 4 , c myc , bax and bcl 10 showed no difference between these two cell lines upon growth factor removal . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
After exposure to soluble CD 95 ligand , Jurkat T cells , but not Ag specific T cells , exhibit loss of BCL 2 and BCL 10 expression whereas BAX expression is not affected . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In addition , we examined expression patterns of the anti apoptotic proteins Bcl 2 and Bcl 10 and the cell death promoting protein Bax in retinae after crushing the optic nerve . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
These lesions also revealed expression of apoptosis promoting factors , such as bax and ICE , inducing cleavage of myofilaments , and of the apoptosis inhibiting proteins bcl XL and bcl 2 which neutralized high bax levels . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Other proteins , like bcl xL , A 1 or mcl 1 have the same anti apoptotic function , but several molecules of the same family , like bcl xS , bax alpha or bak can trigger the opposite effect . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
It shares a conserved domain , BH 3 , with other pro apoptotic proteins , Bax , Bak , Bid , and Hrk , and certain anti apoptosis proteins such as Bcl 2 and Bcl xL . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Induction of anergy resulted in up regulation and persistent expression of moderate amounts of bcl xL and bax and absence of induction of bad . ^^^ Resistance to apoptotic cell death was temporally associated with a dramatic increase of bcl xL and the presence of bcl xL : bax heterodimers . ^^^ Subsequent sensitivity to AICD was associated with down regulation of bcl xL , induction of bad , and the displacement of bax from bcl xL : bax heterodimers . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In the present study , Bcl xL was expressed in the basal cell and spinous cell layers , and Bax was expressed in the spinous cell and granular cell layers . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Expression of Apo 1 / Fas ( CD 95 ) , Bcl 2 , Bax and Bcl 10 in myeloma cell lines : relationship between responsiveness to anti Fas mab and p 53 functional status . ^^^ We studied eight myeloma cell lines for the presence of Bcl 2 , which inhibits apoptosis , of Bax , which counteracts Bcl 2 , of Bcl 10 ( L ) and Bcl 10 ( S ) , which act in an anti and pro apoptotic fashion , respectively , and of Apo 1 / Fas , which induces programmed cell death , when activated by the Apo 1 / Fas ligand or the relevant monoclonal antibody ( mab ) . ^^^ All cell lines constitutively expressed homogenous amounts of Bcl 2 , but displayed different amounts of Bax and Bcl 10 proteins . ^^^ The relative expression levels of Apo 1 / Fas correlated with that of Bax , but not with that of Bcl 2 or Bcl 10 subtypes . ^^^ Furthermore , the effectiveness of the Apo 1 / Fas mab was associated with the relative expression levels of the Apo 1 / Fas and with that of the Bax antigen , but not with that of the Bcl 2 and Bcl 10 antigens . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Release of cytochrome c and decrease of cytochrome c oxidase in Bax expressing yeast cells , and prevention of these effects by coexpression of Bcl xL . ^^^ The characteristics of mitochondria of yeast cells expressing the pro apoptotic gene Bax or coexpressing Bax and the anti apoptotic gene Bcl xL have been investigated in whole cells , isolated mitochondria and permeabilized spheroplasts . ^^^ Coexpression of Bcl xL almost fully prevented the effect of Bax . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Our data also indicate the possibility that a cell death program dependent on the bcl 2 family exists , because of the potential involvement of p 53 , bcl XS and Bax in apoptosis . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bcl 2 , Bcl 10 long , and Bax protein expression were evaluated by immunoblot analysis , and Bcl 2 expression was modulated using antisense technology . ^^^ Although expression of Bcl 10 long and Bax protein were similiar in the two cell lines , Bcl 2 protein expression was 15 fold greater in malignant than in nonmalignant cholangiocytes . ^^^ We compared the apoptotic threshold and expression of the Bcl 2 protein family members , Bcl 2 , Bcl XL , and Bax , in two human cell lines : 1 ) nonmalignant human cholangiocytes immortalized by transfection with the simian virus 40 ( SV 40 ) large T antigen ; and 2 ) a malignant human cholangiocarcinoma cell line . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Protein expression of Fas / APO 1 or bcl 2 , and messenger RNA ( mRNA ) expression of bcl 2 , bcl xL , bax , bak , Fas / APO 1 , Fas ligand ( Fas L ) , c myc , mad , or max were determined . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The expression of several other bcl 2 family members ( bcl 10 , ich 1 , bax , bag , and bak ) and retinoid receptors ( RARalpha , RXRalpha , and RXRbeta ) was not affected by treatment with RAR and / or RXR activating retinoids ; RARbeta RNA was undetectable before and after retinoid treatment . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Homology modeling of Bcl 2 and Bax , based on the Bcl xL structure , suggests that Bax has the strongest potential for membrane insertion . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Caspase dependent apoptosis of COS 7 cells induced by Bax overexpression : differential effects of Bcl 2 and Bcl xL on Bax induced caspase activation and apoptosis . ^^^ We also found that the Bax induced apoptosis of COS 7 cells was suppressed by Bcl xL and Bcl 2 , though both Bcl xL and Bcl 2 similarly prevented etoposide induced apoptosis in COS 7 cells . ^^^ In addition , Bcl xL inhibited the activation of caspase 3 like proteases accompanying Bax induced COS 7 cell death but Bcl 2 did not . ^^^ These results indicate that the caspase activation is essential for Bax induced apoptosis , and that the ability of Bcl 2 and Bcl xL to prevent the Bax induced caspase activation and apoptosis in COS 7 cells could be differentially regulated . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
A 26 amino acid peptide within this domain , which showed significant homology to the alpha helical BH 3 domains of related apoptotic proteins like Bak and Bax , was found to be necessary and sufficient to bind Bcl xL . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Several of these genes , including bcl 2 , bcl 10 , and bax , share homology at the amino acid level in the BH 1 and BH 2 domains , through which they also interact . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
To explore Bcl 2 family member localization in living cells , the green fluorescent protein ( GFP ) was fused to the NH 2 termini of Bax , Bcl 2 , and Bcl XL . ^^^ Confocal microscopy performed on living Cos 7 kidney epithelial cells and L 929 fibroblasts revealed that GFP Bcl 2 and GFP Bcl XL had a punctate distribution and colocalized with a mitochondrial marker , whereas GFP Bax was found diffusely throughout the cytosol . ^^^ The diffuse localization of GFP Bax did not change with coexpression of high levels of Bcl 2 or Bcl XL . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Thus , as previously shown for BAX , BAK , BCL 2 , and BCL XL , the BH 3 domain of BAD is required for its dimerization with other BCL 2 family proteins . ^^^ BAD was further analyzed for its ability to bind to various mutants of BCL 2 and BCL XL that have lost the ability to bind BAX and BAK , some of which retain biological activity and some of which do not . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The pattern of endogenous expression levels of Bax , Bcl 2 , Bcl 10 and Bak , which was not modulated by cisplatin treatment , demonstrated that these Bcl 2 family proteins are not involved in drug induced apoptosis in the TGCT cell lines . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Here , we demonstrate that expression of galectin 3 in human breast carcinoma BT 549 cells inhibits cis diamminedichloroplatinum ( cisplatin ) induced poly ( ADP ribose ) polymerase degradation and apoptosis , without altering Bcl 2 , Bcl 10 ( L ) , or Bax expressions . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We postulated that Mycobacterium tuberculosis could trigger the apoptotic pathway in macrophages , resulting in death of the microorganism by modulating the expression of bcl 2 , bax , bcl xL , and bcl xS . ^^^ At the same time points , there was no change in the expression of Bax or Bcl xS , inducers of apoptosis , but Bcl xL , another inhibitor of apoptosis , was minimally upregulated by BCG . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
HL 60 / Bcl 2 cells displayed a 5 fold increase in Bcl 2 protein compared with empty vector counter parts ( HL 60 / pCEP4 ) but comparable levels of Bax , Mcl 1 , and Bcl xL . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Here we demonstrate that , in addition to the previously identified A 1 , four other members of the Bcl 2 family , Bcl 2 , Mcl 1 , Bcl 10 ( L ) , and Bax , are expressed in endothelial cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bcl xL overexpression restricts heat induced apoptosis and influences hsp 70 , bcl 2 , and Bax protein levels in FL5 . 12 cells . ^^^ The current study , using control and bcl xL overexpressing IL 3 dependent FL5 . 12 cells , compared the effects of 1 h of acute heat stress ( 42 degrees C ) followed by 1 , 4 , and 8 h recovery ( 37 degrees C ) on hsp 70 , bax , bcl 2 , and bcl xL protein levels and apoptosis . ^^^ Immunoblotting revealed a time dependent increase in hsp 70 protein levels following 1 h of heat stress in control , but not bcl xL overexpressing cells . bcl 2 protein levels were lower in bcl xL overexpressing cells than in controls , but decreased in both cell lines after heat stress . bax protein levels in bcl xL overexpressing cells were decreased approximately 80 % below baseline levels 1 h post heat shock . ^^^ The rapid loss of bax protein following heat stress in bcl xL overexpressing , but not control , cells may contribute to their resistance to apoptosis . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bcl XL , an inhibitor of apoptosis , and Bax , which can accelerate apoptosis , are expressed at maximal levels 24 h after initial isolation of the cells and again after day 25 in heavily mineralized bone tissue nodules . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Further , there was no apparent correlation of the steady state level of the apoptosis regulating proteins , Bcl 2 , Bcl XL , Bax and Ich 1 , with tumorigenicity of the prostate cells xenografted in nude mice , aggressiveness of tumors grown in nude mice , and induction of apoptosis by 9NC . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
OBJECT : Genes known to be involved in the regulation of apoptosis include members of the bcl 2 gene family , such as inhibitors of apoptosis ( bcl 2 and bcl xl ) and promoters of apoptosis ( bax ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Similarly , the Bcl 2 family member , Bcl 10 ( L ) also blocked staurosporine induced cell death in MN9D cells whereas overexpression of Bcl 10 ( S ) or Bax did not . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
This preliminary results of very small group of patients could indicate that hepatocytes in the HBV infection are in the quiescent stage as in the controls and that the cell cycle regulation during infection could be controlled by other genes such as bax , bcl Xs , FAS etc . , but further studies are required . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We have selected bcl 10 gene expression for study because there is increasing evidence that proteins encoded by the bcl 2 gene family ( bcl 2 , bcl 10 , bax etc ) play a role in the regulation of programmed cell death . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
This line , which expresses p glycoprotein and serves as a model of multidrug resistance in multiple myeloma cells , demonstrated an up regulated expression of BCL 10 L , which was relatively specific , in that BCL 2 or BAX expression was not altered . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Additionally , PGE 2 inhibits programmed cell death caused by SC 58125 and induces Bcl 2 expression , but did not affect Bcl 10 or Bax expression in human colon cancer ( HCA 7 ) cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bcl 2 , Bax and Bcl 10 expression following hypoxia ischemia in the infant rat brain . ^^^ Expression of Bcl 2 , Bax and Bcl 10 was examined in control and hypoxic ischemic rats using immunohistochemistry and Western blotting . ^^^ Bcl 2 , Bax and Bcl 10 immunoreactivity decreased in necrotic cells , but about 60 % of cells with apoptotic like morphology and cells with granular chromatin degeneration were stained with antibodies to Bcl 2 , Bax or Bcl 10 . ^^^ These results suggest that Bcl 2 , Bax , Bcl xL and Bcl xS do not play a leading role in the fate of damaged nerve cells following a severe hypoxic ischemic insult of the developing brain . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Levels of Bcl 2 , Mcl 1 , Bcl xL , and Bax each varied over a more than 10 fold range in different pretreatment leukemia specimens . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The farnesyltransferase inhibitor , FPT inhibitor 3 upregulates Bax and Bcl xs expression and induces apoptosis in human ovarian cancer cells . ^^^ Here , we report that a newly synthesized farnesyltransferase inhibitor , FPT inhibitor 3 , upregulates Bax and Bcl xs expression and induces apoptosis in human ovarian cancer cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In this study we investigated what effect the differentiation agent butyrate had on the cellular levels of the apoptosis regulators BCL 2 , BCLX ( L ) and BAX and on radiation induced apoptosis . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Differential regulation of Bax , Bcl 2 , and Bcl 10 proteins in focal cortical ischemia in the rat . ^^^ At the border of the ischemic lesion , two areas were distinguished : 1 2 days after induction of photothrombosis , pyknotic cells located immediately adjacent to the lesion core displayed nuclear Bcl 10 and Bax immunoreactivity . ^^^ Double staining for each of the Bcl 2 family proteins and TUNEL revealed that DNA strand breaks and nuclear fragmentation seen in cells located in the lesion core were often associated with increased levels of Bax , but not with elevated Bcl 2 or Bcl 10 protein levels , suggesting a role for Bax in the induction of apoptotic death in these cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Relationship between nitrogen mustard drug resistance in B cell chronic lymphocytic leukemia ( B CLL ) and protein expression of Bcl 2 , Bax , Bcl 10 and p 53 . ^^^ Several genes have been implicated in the regulation of apoptosis including bcl 2 , bax , bcl 10 and p 53 . ^^^ Using Western blot analysis , we examined the levels of Bcl 2 , Bax , Bcl 10 and p 53 protein expression and determined whether the levels of these proteins correlated with in vitro drug resistance in CLL patients ' lymphocyte samples . ^^^ Our investigations suggest that in CLL , NM drug resistance develops without any detectable alteration of Bcl 2 , Bax or Bcl 10 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In the centre of the lesion , Bax protein increased and Bcl 2 and Bcl 10 proteins decreased after loss of microtubule associated protein 2 antigenicity occurred , but at the border of the lesion , the former changes preceded loss of microtubule associated protein 2 antigenicity . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We studied the expression of three members of the Bcl 2 protein family , Bcl 2 , Bcl 10 , and Bax , in a selection of senile and DS related AD patients as well as in controls . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
BH 4 of Bcl 2 could be replaced by that of Bcl 10 without perturbing function but not by a somewhat similar region near the N terminus of Bax . ^^^ Bcl 2 and close homologues such as Bcl xL promote cell survival , while other relatives such as Bax antagonize this function . ^^^ Deletion of BH 4 rendered Bcl 2 ( and Bcl xL ) inactive but did not impair either Bcl 2 homodimerization or ability to bind to Bax or five other pro apoptotic relatives ( Bak , Bad , Bik , Bid or Bim ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We also found that the expression of p 53 , p21waf1 / cip1 , Bcl 2 , Bax , Bcl xL , Bad and cyclins D 1 , E , A and B did not show any significant changes following c Myc induction . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We analyzed the expression of genes promoting apoptosis ( fas / fasL1 and bax ) and those inhibiting apoptosis ( bcl 2 and bcl xL ) in lymphocytes from aging and young subjects at the protein level , using flow cytometry / Western blotting , and at the mRNA level , using quantitative PCR . ^^^ No significant difference was observed in Bcl xL expression between aging and young ; however , the ratio of Bax : Bcl xL was increased in aging . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The apoptotic population in the cells expressing Bax 112 192 was not decreased by co expression of Bcl 2 or Bcl XL , while Bcl 2 or Bcl XL suppressed apoptosis in the cells expressing native Bax . ^^^ Therefore , Bax induces apoptosis by its own activity without blocking the anti apoptotic activity involved in Bcl 2 or Bcl XL . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The expression of the Bcl 2 family proteins Bax , Mcl 1 , Bcl 2 , and Bcl xL , was examined in human peripheral blood eosinophils or in umbilical cord blood derived eosinophils . ^^^ Incubation of both eosinophil types for 1 to 3 days in a cytokine deprived medium led to apoptosis , without changes in the expression of Bax , Mcl 1 , Bcl 2 , or Bcl xL . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Among the various Bcl like proteins , the effects and functions of the Bcl 10 and Bax proteins in controlling apoptosis induced by cancer chemotherapy have been studied recently . ^^^ The Bcl xL and Bax alpha control points : modulation of apoptosis induced by cancer chemotherapy and relation to TPCK sensitive protease and caspase activation . ^^^ Modulation of apoptosis either negatively by Bcl xL or positively by Bax alpha resides downstream of the primary mechanism of action of anticancer drugs , suggesting that they act primarily as intrinsic control points following cytotoxic drug injuries . ^^^ Evidence obtained using a combination of assays including cell free systems and enzyme activity assays now suggests that Bcl xL and Bax alpha control points function upstream of TPCK sensitive protease and caspase activation . ^^^ Bcl xL delays and prevents activation of apoptotic protease cascades whereas Bax alpha shows the opposite effect , accelerating their activation . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Immunoblot analysis of primary adenocarcinomas revealed expression of the anti apoptotic proteins Bcl 2 , Bcl 10 ( L ) , Mcl 1 , and BAG 1 , as well as the pro apoptotic proteins Bax , Bak , and CPP 32 , in at least 2 of the 3 tumors examined . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Alteration of proteins regulating apoptosis , Bcl 2 , Bcl 10 , Bax , Bak , Bad , ICH 1 and CPP 32 , in Alzheimer ' s disease . ^^^ Apoptosis is regulated by the B cell leukemia 2 gene product ( Bcl 2 ) family ( Bcl 2 , Bcl 10 , Bax , Bak and Bad ) and the caspase family ( ICH 1 and CPP 32 ) , with apoptosis being prevented by Bcl 2 and Bcl 10 , and promoted by Bax , Bak , Bad , ICH 1 and CPP 32 . ^^^ In the cytosolic fractions , the level of Bcl 10 beta was increased , while Bcl xL , Bax , Bak , and Bad and ICH 1L were unchanged . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Diminished susceptibility to chemotherapy has also been attributed , in in vitro systems , to alterations in the levels of bcl 2 , bax , or bcl 10 . ^^^ Among these , bcl 2 and bcl xL prevent cells from entering apoptosis , whereas bax and bcl xS can induce cell death . ^^^ We analyzed the expression of bcl 2 , bax , bcl xL , and bcl xS in normal and neoplastic ovarian tissues by reverse transcriptase PCR and Western blotting . ^^^ Interestingly , the levels of these genes in normal and neoplastic tissues were significantly different : bcl 2 was higher in normal tissue ( P < 0 . 002 ) , whereas bax and bcl xL were higher in carcinoma ( P < 0 . 018 and P < 0 . 030 , respectively ) . bcl xS was present at low levels in 83 % of neoplastic samples and was undetectable in normal tissue . ^^^ Only bax and bcl xL were correlated with progesterone receptor levels ( n = 29 , r = +0 . 44 , P < 0 . 0189 , and r = 0 . 40 , P < 0 . 035 , respectively ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
A comparative examination of HVS transformed T cell clones and their native parental clones revealed that the expression of Bcl 2 , Bcl 10 ( L ) , Bax , and members of the tumor necrosis factor receptor ( TNF R ) superfamily with a death domain , namely , TNF RI , CD 95 , and TRAMP , were not modulated by HVS . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Throughout the course of the disease , which peaked 12 14 days after inoculation and was followed by clinical recovery , we analyzed the DNA content of the spinal cord inflammatory cells to assess apoptosis and , simultaneously , we measured the expression of five proteins ( Fas , Fas ligand ( Fas L ) , Bcl 2 , Bcl 10 and Bax ) which modulate the apoptotic process . ^^^ There was no evidence , however , that the apoptotic regulators Bcl 10 and Bax influenced the susceptibility to apoptosis . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Sensitive S 49 cells and resistant variants did not differ in the expression levels of the apoptosis regulating genes bax , bad , bcl 10 and bcl 2 , the status of the p 53 gene nor in a different requirement for the growth factors 2 2 , IL 4 or IL 9 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We investigated apoptotic cell death in the cerebellum of five cases of XP group A ( XPA ) , four cases of CS , and twelve controls , using TdT mediated DIG dUTP nick end labeling ( TUNEL ) and immunohistochemical staining for bcl 2 , bcl 10 , p 53 , bax , BDNF and Trk B . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
OBJECTIVE : To investigate the nuclear localization of the transcription factor NF kappa B , the status of apoptosis and the expression of the Fas antigen , Fas ligand , Bcl 2 , Bcl xL and Bax by synovial cells . ^^^ An overexpression of Bax compared to Bcl xL was seen in the synovial tissues ( ST ) of patients with ongoing apoptosis , but not in patients with few apoptotic cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The effect of TGF beta 1 and DEX on cellular amounts of several apoptosis related proteins , members of the Bcl 2 family , Bcl 2 , Bcl xL , Bcl xS , Bad , and Bax was also examined . ^^^ Bcl 2 and Bcl xS proteins were not detected , and Bax and Bad content did not change by treatment with TGF beta 1 or DEX . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bcl 2 , Bcl XL , and Bax are members of the Bcl 2 family that play important roles in apoptosis regulation . ^^^ However , we recently found by subcellular fractionation that whereas Bcl 2 is predominantly a membrane protein as previously reported , Bax and a significant fraction of Bcl XL are soluble in thymocyte and splenocyte extracts . ^^^ Induction of apo ptosis which causes the insertion of the soluble form of Bax into membranes did not result in appreciable Bax / Bcl XL , Bax / Bcl 2 or Bax / Bax dimer formation as determined by cross linking studies . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The expression of several apoptosis regulating proteins , including the Bcl 2 family proteins Bcl 2 , Bcl XL , Mcl 1 , Bax , Bak , and BAD ; the Bcl 2 binding protein BAG 1 ; and the cell death protease Caspase 3 ( CPP 32 ) , was evaluated by immunoblotting using 58 peripheral blood B CLL specimens from previously untreated patients . ^^^ Expression of Bcl 2 , Mcl 1 , BAG 1 , Bax , Bak , and Caspase 3 was commonly found in circulating B CLL cells , whereas the Bcl XL and BAD proteins were not present . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Recombinant Bcl XL protein abrogated Bax induced release of Cyt c from isolated mitochondria and prevented caspase activation . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Here we have examined the expression of several proteins involved in the susceptibility to apoptosis in 20 human gliomas , including the BCL 2 family proteins BCL 2 , BCL 10 , BAX and MCL 1 , as well as p 53 and RB . ^^^ There was good correlation between expression of the functional antagonists , BCL 2 / BCL 10 and BAX , suggesting that changes in the BCL 2+BCL X / BAX ratio are not responsible for the differential response of glioma patients to chemotherapy . ^^^ There was no prominent association of outcome with the expression patterns of p 53 , RB , BCL 2 , BCL 10 or BAX . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The identity of the insert of each clone was determined by slotblots of the DNA amplified from individual colonies and by hybridization with radioactive probes specific to the bcl 2 , bcl 10 , or bax genes . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In addition , the expression of Bax , Bcl 2 , Bcl 10 ( L ) , and p 53 messenger RNA ( mRNA ) was analyzed by in situ hybridization . ^^^ The mRNAs for Bax and p 53 also were increased , whereas no changes were detected in Bcl 2 and Bcl 10 ( L ) mRNA levels . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Baseline levels of message were detected for 3 ced 3 ( CPP 32 , Ich 1 and ICE ) and 4 ced 9 homologs ( bcl 10 , MCL 1 , bcl 2 and bax ) in the frontal cortex . ^^^ Positive ( ICE , ICErel 2 , ICErel 3 , Ich 1L , CPP 32 , mch 2 , mch 3 , bcl xS , bax and bak ) and negative ( bcl 2 , bcl xL , MCL 1 and Ich 1S ) regulators of apoptosis were successively examined using a semi quantitative technique of reverse transcription polymerase chain reaction ( RT PCR ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Surface plasmon resonance was used to examine the kinetics of dimerization as a function of pH between the anti apoptotic protein Bcl XL ( applied in the mobile phase ) and three other members of the Bcl 2 family : Bcl 2 , Bax , and Bid ( immobilized on biosensor chips ) . ^^^ At pH 4 . 0 , the circular dichroism spectra of Bcl XL and Bax were essentially unchanged relative to pH 7 . 0 7 . 4 , indicating a complete retention of alpha helical secondary structure at low pH and excluding gross denaturation of the proteins . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The position of a single intron was conserved in comparison to other members of the Bcl 2 family , namely Bax , CED 9 , Bcl 10 and Bcl 2 , but all other introns were displaced , consistent with a divergent phylogeny . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
METHODS : Human glioblastoma cells were treated with or without TAM and / or IGF 1 in vitro and evaluated for : viability by the 3 ( 4 , 5 dimethylthiazol 2 yl ) 2 , 5 diphenol tetrazolium bromide cleavage assay ; apoptosis by histochemical analysis of nuclear morphology and 3 ' OH DNA fragments ; and expression of the IGF 1 receptor , and the bcl 2 , bcl xL , and bax proteins by immunoblot analysis . ^^^ Exogenous IGF 1 stimulated WITG 3 cell proliferation and significantly ( p < 0 . 05 ) antagonized the cytotoxic effects of TAM in a dose dependent fashion ; IGF 1 , but not TAM , enhanced expression of bcl 2 and bcl xL proteins ; however , bax protein expression was unchanged by either treatment . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Expression of the death related proteins ( DRPs ) Bcl 2 , Bax , Bcl 10 and Bak that regulate cell survival and death was examined using immuno histochemical methods in a group of 142 T 1 ( < 2 cm ) ductal breast carcinomas . ^^^ Expression of these DRPs was associated significantly with the HG of the tumors : Bcl 2 and Bak expression was predominant in HG I / II tumors , whereas expression of Bcl xL and Bax was commonly observed in HG 3 tumors , as occurs for p 53 over expression . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
There were no changes in levels of Bcl 2 , Bcl XL , or 24 kDa Bax over 72 hr after exposure to cisplatin or paclitaxel , but each agent led to up regulation of Bak and 21 kDa Bax in A 2780 cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Semi quantitative RT PCR revealed that expression of c myc and bcl 2 genes was reduced during the apoptotic process , while expression of bax and bcl 10 ( L ) genes was not changed . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Expression of the Bcl 2 family of apoptosis related genes ( bcl 2 , bcl 10 , mcl 1 , and bax ) and the proliferation and apoptosis related genes p 53 and cyclin D 1 were determined in 40 low T stage laryngeal carcinomas and in uvular epithelium from patients without SCC . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Expression of p 53 , p21 / WAF / CIP , Bcl 2 , Bax , Bcl 10 , and Bak in radiation induced apoptosis in testicular germ cell tumor lines . ^^^ Expression of p21 / WAF / CIP was determined by Northern blot analysis and immunoblotting was used to monitor p 53 , Bax , Bcl 2 , Bcl 10 , and Bak protein levels . ^^^ Constitutive expression of Bax , Bcl 2 , Bcl 10 , and Bak was not affected by radiation and showed no correlation with cell susceptibility to radiation induced apoptosis . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The mitochondrial permeability transition ( PT ) pore , also called mitochondrial megachannel or multiple conductance channel , is a multiprotein complex formed at the contact site between the mitochondrial inner and outer membranes , exactly at the same localization at which Bax , Bcl 2 , and Bcl XL are particularly abundant . ^^^ Experiments involving the purified PT pore complex indicate that Bax , Bcl 2 , and Bcl XL exert at least part of their apoptosis regulatory function by facilitating ( Bax ) or inhibiting ( Bcl 2 , Bcl XL ) PT pore opening . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Examination of apoptosis related gene expression by RT PCR showed that bcl 2 expression was greater in 4 pp R than in RVC . p 53 , bax and bcl xL were expressed at the same level in 4 pp R and RVC cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
To examine which proteins are involved in this apoptosis , we examined changes in protein levels of the Bcl 2 family , including Bcl 2 , Bcl 10 and Bax . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Variable levels of bcl 2 , bcl 10 and bax mRNA in bladder cancer progression . ^^^ We investigated the expression of the anti apoptotic genes bcl 2 and bcl 10 and the pro apoptotic gene bax in bladder tumors and normal samples from urinary bladder , using RT PCR analysis . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The IL 7 trophic affect correlated with increased intracellular levels of Bcl 2 and decreased levels of Bax , whereas no Bcl 10 ( L ) , Bcl w , or Bad was detectable . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Recent studies have focused on the role that programmed cell death ( i . e . , apoptosis ) plays in both normal and neoplastic growth : certain genes can either suppress ( e . g . , Bcl 2 , Bcl xL ) or promote ( e . g . , Bik , Bax , Bak ) apoptosis . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
There was no statistically significant change in the expression of Bax , Bcl xl , Bcl 2 , or p 53 following androgen withdrawal . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Immunohistochemical analysis of bcl 2 , bax , mcl 1 , and bcl 10 expression in ovarian surface epithelial tumors . ^^^ The expression of bcl 2 family proteins was investigated in 28 ovarian surface epithelial tumors , including serous and mucinous benign , borderline , and malignant tumors by immunohistochemical staining with antibodies to bcl 2 , bax , bcl 10 , and mcl 1 proteins . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In many tissues the apoptosis related gene products act in cohort : Bcl 2 and Bcl xl promoting survival of a cell , whilst Bax promotes cell death often positively regulated by the tumour suppressor gene p 53 . ^^^ Western blot analysis showed that : ( 1 ) Bcl 2 and p 53 were absent from interstitial Leydig cells but were expressed in the seminiferous tubules . ( 2 ) Bax protein although expressed in the interstitium was not present in the Leydig cells . ( 3 ) Bcl xl in Leydig cells was transiently increased after EDS . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Moreover , BI 1 can interact with Bcl 2 and Bcl XL but Bax or Bak , as demonstrated by in vivo cross linking and coimmunoprecipitation studies . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We tested the role of bcl 2 by transfecting 2 low bcl 2 expressing myeloma cell lines , ARP 1 and 8226 , with a bcl 2 expression vector and compared the effects of DEX and MEL on apoptosis , cell cycle distribution and the levels of proapoptotic ( bax ) and antiapoptotic ( bcl 2 , bclx ) proteins . ^^^ The levels of bclx and bax remained unchanged following treatment with either MEL or DEX . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In this study we have investigated by Western blotting the expression pattern of Bcl 2 and its homologues Bax , Bak , Bcl xL , Bcl xS , Mcl 1 and Bad in 12 distant lymph node metastases from patients who have been treated by different regimes , in nine newly established cell lines of these metastases , in three cell lines obtained from other sources and in primary melanocytic cell lines from three neonatal and two adult subjects . ^^^ Taken together , our data suggest that Bax , Bak , Bad , Bcl xL and Mcl 1 are expressed in addition to Bcl 2 in both normal melanocytes and in cell lines established from melanoma metastases . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In this study , we screened for the expression of bcl 2 homologues ( bcl 2 , bax , bcl xl , and bcl xs ) and Fas ligand ( FasL ) by RT PCR method in grafts during acute rejection in rats following liver transplantation . ^^^ Both bax and bcl xs ( inducers of apoptosis ) mRNA levels increased steadily in the allografted group from postoperative day ( POD ) 2 to 8 , while no remarkable changes of bcl 2 and bcl xl expression ( inhibitors of apoptosis ) were recognized . ^^^ Our results indicated , for the first time , that rejection induced cell apoptosis is closely associated with upregulation of bax and bcl xs expression besides FasL , but not with down regulation of bcl xl . . ^^^ Expression of bcl 2 homologue mRNAs in rat liver allograft : rejection induced cell apoptosis is associated with upregulation of bax and bcl xs expression . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In particular , the content of the antiapoptotic products Bcl 2 and Bcl XL resulted to be increased in treated cells , whereas the expression of the proapoptotic protein Bax remained unaltered . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
To examine whether the altered sensitivity to this apoptotic signal was correlated with the expression of proteins of the bcl 2 family , the expression of bcl 2 , bcl 10 , and bax proteins was determined . ^^^ CD28+ and CD 28 CD4+ T cells could not be distinguished by the levels of bax or bcl xL protein ; however , CD4+CD28 T cells expressed higher amounts of bcl 2 protein than did CD4+CD28+ T cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
To elucidate the role of Bcl 2 family members in the inhibition of eosinophil apoptosis , we examined the expression of the known anti apoptotic genes Bcl 2 , Bcl xL , and A 1 , as well as Bax and Bcl xS , which promote apoptosis in other systems . ^^^ We show herein that freshly isolated human eosinophils express significant amounts of Bcl xL and Bax , but only little or no Bcl 2 , Bcl xS , or A 1 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Some of them , Bcl 10 , and Bax have been shown to be involved in neuronal death during development in some pathological situations . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Here , we report that the expression of bcl 2 , bcl xL , bcl xS , bax and bad mRNA as well as of Bcl 2 , Bax , Bcl XL , Bcl XS and Bag 1 proteins is not modulated in these two paradigms of neuronal cell death . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bcl 2 , Bax , and Bcl 10 expression in the CA 1 area of the hippocampus following transient forebrain ischemia in the adult gerbil . ^^^ Immunohistochemistry and Western blotting to Bcl 2 , Bax , and Bcl 10 was examined in control ( age matched , non operated and sham operated ) and ischemic gerbils . ^^^ Bcl 2 , Bax , and Bcl 10 were localized in dying cells , thus suggesting that expression of Bcl 2 was not sufficient to prevent nerve cells from dying . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Quantitative Western blotting was used to examine the protein expression of P 53 and P21WAF 1 , Bcl 2 and Bcl 10 ( L ) ( anti apoptotic proteins ) , and Bax , Bak , and Bad ( proapoptotic proteins ) . ^^^ Upon deprivation , these cancer cells up regulated P 21 and Bcl 2 and / or BclX ( L ) , lost response to withdrawal induced up regulation of Bax / Bad / Bak or decreased or even completely lost Bax expression and expressed some novel proteins such as P 25 and P54 / 55 complex . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bcl 10 ( l ) Bax interaction after transient global ischemia . ^^^ We used immunoblots to estimate levels of Bcl 2 , Bcl 10 ( l ) , and Bax at various times after carotid occlusion . ^^^ These studies demonstrated that Bcl 10 ( l ) association with Bax increases after ischemia . ^^^ Therefore , Bax may disrupt the more favorable Bcl 10 ( l ) ( Bcl 2 ) interactions necessary for normal neuronal functioning and thus promote transient ischemic death . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The expression of Bcl 2 , Bcl xl , Bax , p 53 and poly ( ADP ) ribose polymerase ( PARP ) was demonstrated in tissue extracts by Western blotting . ^^^ However , in the long term treated testes , Bcl xl and PARP expression declined , Bax and p 53 protein concentrations were unchanged , and Bcl 2 was up regulated . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Immunochemical analysis revealed that expression of apoptosis related gene products , such as Bcl 2 , Bcl xL and Bax , was below detectable levels with both cell types . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The bcl 2 gene was expressed in 54 % of the tumors ( 19 / 35 ) , whereas bcl 10 and bax gene products were present in only a low fraction of these lymphomas ( 4 / 35 ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
During the process of terminal differentiation toward mature neutrophils , the anti apoptotic proteins Bcl 2 and Bcl 10 become down regulated and eventually cease to be expressed , whereas the death promoting Bcl 2 homologue , Bax , persists . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
To investigate the molecular mechanism of glandular parenchyma destruction in Sjgren ' s syndrome ( SS ) , Bcl 2 , Bax , Bcl 10 , and Bak expression were studied . ^^^ Both SS and control salivary gland ductal epithelial cells expressed Bcl 2 , Bax , and Bcl 10 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bcl 2 family proteins are key regulators of apoptosis and function as cell death antagonists ( e . g . , Bcl 2 , Bcl XL , and Mcl 1 ) or agonists ( e . g . , Bax , Bad , and Bak ) . ^^^ Here we report that among the Bcl 2 family of proteins tested ( Bcl 2 , Bcl XL , Mcl 1 , Bax , Bad , and Bak ) , Bcl XL was unique in that its protein levels were tightly regulated by hemopoietins in both immortal and primary myeloid progenitors . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We examined the expression of Bax , Bcl 2 , Bcl 10 , and Mcl 1 in human benign nevi , primary MM , and metastatic MM using immunohistochemistry . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Formalin fixed tissue sections were immunohistochemically stained for apoptosis associated proteins ( Bcl 2 , Bcl 10 , Bax , Bak , p 53 , MDM 2 , BHRF ) . ^^^ Most lymphomas were positive for Bcl 10 and Bax , and few expressed Bak . ^^^ The irregular expression of Bcl 2 , Bcl 10 , Bax , and Bak in oral lymphomas indicates dysfunctional apoptotic mechanisms in these tumors . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In yeast , Bax is lethal , and this activity is suppressed by Bcl xL , Bcl 2 , and A 1 . ^^^ A second group , which includes Bax , is lethal , whereas a third class , including Bcl xS , potentiates killing , although the members are not lethal by themselves . ^^^ Co expression of Bcl xS did not diminish the ability of any of the anti apoptotic members to antagonize Bax . ^^^ Therefore , Bcl xS may act downstream of Bax and in a pathway that is conserved in yeast . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Similarly , we analyzed the expression of bcl 2 related proteins bcl xL , bax , bad , and bak before and during ex vivo expansion . ^^^ These cells expressed strongly the bcl xL protein ( > 95 % ) but were bax low ( 4 % to 12 % ) , bad low ( 0 % to 0 . 8 % ) , and bak low ( 0 % to 3 % ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In the yeast cell assay , BOD interacts with diverse antiapoptotic Bcl 2 proteins [ Mcl 1 , Bcl 2 , Bcl xL , Bcl w , Bfl 1 , and Epstein Barr virus ( EBV ) BHRF 1 ] but not with different proapoptotic Bcl 2 proteins ( BAD , Bak , Bok , and Bax ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We did not observe any changes in Bcl 2 or Bcl 2 related proteins ( Bcl 10 , Bax , and Bad ) in control or KCREB transfected cells before or after treatment with Tg . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
To elucidate molecular events in the apoptosis , expressions of Bcl 2 protein family members , such as Bcl 2 , Bcl 10 and Bax , and heat shock protein 70 ( HSP 70 ) were measured by western blotting using specific antibodies . ^^^ The levels of Bax and Bcl Xs remained largely unchanged , but the Bcl 2 and Bcl XL expression showed down regulation . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Our BAX deletion constructs and minimal domain constructs indicated that the BH 3 domain was required for BAX homodimerization and heterodimerization with BCL 2 , BCL XL , and MCL 1 . ^^^ This suggests that BAX ' s killing function reflects mechanisms beyond its binding to BCL 2 or BCL XL to inhibit them or simply displace other protein partners . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Northern blot analysis revealed an increase in bax mRNA levels and a decrease in bcl 10 mRNA levels coincident with luteal cell apoptosis induced by estradiol withdrawal . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bleomycin induced apoptosis was accompanied by decreases in bcl 2 and bcl xl and increases in p 53 , bak , and bax protein levels . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bcl 2 , Bax and Bcl 10 expression in neuronal apoptosis : a study of mutant weaver and lurcher mice . ^^^ We investigated the expression of the apoptosis modulating proteins Bcl 2 , Bax and Bcl 10 in the cerebellum of mutant lurcher and weaver mice . ^^^ Instead apoptotic lurcher Purkinje cells exhibited increased Bax and Bcl 10 expression , while surviving cells had an expression pattern similar to that of healthy littermates . ^^^ Increased Bax expression was also found in apoptotic weaver germinal cells , while no change of Bcl 10 expression was detected . ^^^ The observed expression patterns of Bcl 2 , Bax and Bcl 10 protein in apoptotic lurcher and weaver neurons support the hypothesis that the execution of neuronal apoptosis involves increased expression of Bax , which could represent a general mechanism in diverse neurodegenerative processes . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Hyperoxia induces a marked increase in RNA or protein levels of p 53 , bax , bcl 10 , and Fas , which are known to be expressed in certain types of apoptosis . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
A dose and time response study revealed that 5 nmol of MK886 / 10 ( 6 ) cells was sufficient to induce apoptosis both in control and bcl xL cells , respectively , but to different degrees . bcl xL and bcl 2 proteins , but not bax or FLAP , were decreased by 4 h after 5 nmol of MK886 / 10 ( 6 ) cells in both cell lines , although the higher levels of bcl xL in overexpressors took longer to disappear . ^^^ This early loss of bcl xL and bcl 2 was not attributable to generalized proteolysis , as shown by Coomassie Blue staining and by the maintenance of bax . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In contrast , the ratio of expression of the proapoptotic gene bax to antiapoptotic gene bcl xL was many times higher in immature than mature neurons , both in vivo and in vitro . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
This increase in paclitaxel or etoposide induced apoptosis of HL 60 / Apaf 1 cells was not associated with any significant alterations in Bcl 2 , Bcl xL , Bax , Fas , or Fas ligand expression . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bcl 2 , Bcl 10 ( L ) , Bax , Bad , Bak and p 53 protein expression was analysed by Western blotting . ^^^ There was a significant correlation between chemosensitivity and Bcl 10 ( L ) to Bax ratio , rather than Bcl 2 to Bax . ^^^ In conclusion , these results suggest that some members of the Bcl 2 family of proteins , in human colon cancer cell lines , are modulated by 5 FU and that the ratio of Bcl 10 ( L ) to Bax may be related to chemosensitivity to 5 FU . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The proteins evaluated were p 53 and six members of the Bax / Bcl 2 family : three proapoptotic proteins ( Bax , Bak , and Bcl xS ) and three survival factors ( Bcl 2 , Bcl xL , and Mcl 1 ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Expression of the Bcl 2 , Mcl 1 , Bcl 10 , Bax , and Bak proteins was analyzed to determine whether the differences in MCF 7 cell sensitivity to apoptosis could be correlated to the differential expression of these proteins . ^^^ Whereas Bak , Bcl 10 , and Mcl 1 levels were identical between variants , the levels of Bcl 2 were 3 . 5 3 . 8 fold higher and the levels of Bax were 1 . 5 1 . 7 fold lower in the resistant variants ( M and L ) as compared with those of the sensitive variant ( N ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We have previously examined the involvement of the B cell leukemia 2 gene product ( Bcl 2 ) family proteins ( Bcl 2 , Bcl 10 , Bax , Bak , and Bad ) in Alzheimer ' s disease ( AD ) and found that Bcl 2 , Bcl 10 , Bak , and Bad were upregulated . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
RT PCR shows that in REHIPs , Abeta decreases mRNA expression of Bcl 2 , as well as the ratio of Bcl xL / Bcl xS , with little effect on Bax expression . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Treatment of LNCaP cells with 10 nm Taxol led , after 24 h , to relatively specific and almost total down regulation of bcl xL protein in the absence of alteration of bax , bak , or bcl 2 levels . ^^^ In contrast , treatment of LNCaP cells with estramustine induced apoptosis , but this was not associated with any change in the intracellular level of bcl xL or bax protein . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The expression levels of Bcl 2 , Bax , and Bcl XL were not changed following the co treatment with inostamycin plus paclitaxel , whereas the activated form of caspase 3 was markedly increased . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Results from Western blot analysis indicate that WSU CLL cells express high levels of Bcl 2 , Bcl xL and c myc , and a low level of Bax . p 53 in untreated WSU CLL cells is undetectable . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Apoptosis is co regulated by the conserved family of Bcl 2 related proteins , which includes both its agonists ( Bax ) and antagonists ( Bcl 10 ( L ) ) . ^^^ Overexpression of Bax is lethal in S . cerevisiae , whereas simultaneous overexpression of Bcl 10 ( L ) rescues the cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The expression of Bax was clearly induced only on IL 2 stimulated or PMA plus ionomycin stimulated PBLs and that of other Bcl 2 family proteins such as Bcl 10 and Bad could not be detected on human PBLs , including IL 2 stimulated or PMA plus ionomycin stimulated PBLs . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Members of the Bcl 2 family of proteins , Bcl 2 , Bcl 10 ( L ) , Bcl Xs and Bax , are considered to play important roles in the regulation of apoptosis and drug resistance . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Importantly , this effect was associated with binding of HA BAD to BCL xL and concomitant disruption of BAX : BCL xL interaction . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bax induced mitochondrial changes were inhibited by recombinant Bcl xL and transgene derived Bcl 2 , antiapoptotic members of the Bcl 2 family , as well as by oligomycin , suggesting a possible regulatory effect of F0F1 ATPase on Bax induced mitochondrial changes . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Under respiratory growth conditions , Bcl 10 ( L ) and Bcl 2 are unable to overcome yeast cell death triggered by a mutant Bax protein lacking the membrane anchor . ^^^ However , the death inhibitory proteins Bcl 10 ( L ) and Bcl 2 fail to rescue Bax delta mediated growth inhibition under conditions promoting respiration , although they bind Bax delta in the cell . ^^^ Results in Jurkat T cells corroborate that Bcl 10 ( L ) is much less efficient at rescuing mammalian cells from the effect of Bax delta than from full length Bax . ^^^ We have also inquired if the respiration dependent toxicity of Bax and Bax delta in yeast is nullified by Bcl 10 ( L ) delta and Bcl 2delta , molecules which lack membrane anchors but bind Bax in the yeast two hybrid system . ^^^ It appears that , under conditions which facilitate respiration in yeast , Bcl 10 ( L ) delta and Bcl 2delta are incapable of rescuing both Bax containing and Bax delta containing cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
METHODS : Liver biopsies from 15 early ( stages 1 and 2 ) and 14 late ( stages 3 and 4 ) cases of PBC and 15 normal cases were examined immunohistochemically for expression of p 53 , CD95 / Fas , bax , bcl 10 , bcl 2 and the proliferation marker Ki 67 . ^^^ RESULTS : CD95 / Fas , bax and bcl 10 were identified in biliary epithelium in 8 / 15 , 11 / 15 and 8 / 15 normal biopsies . ^^^ In cases of PBC surviving bile ducts showed strong bax and bcl 10 expression . ^^^ In cases showing a marked ductular reaction there was increased reactivity for bax and bcl 10 in ductules . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The effect of these cytokines was paralleled by up regulation of Fas expression and down regulation of Bcl 2 and Bcl xL but not Bax . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Furthermore , Bax and Bcl xs , two death promoting proteins of the Bcl 2 family , were up regulated following BA treatment . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Pretreatment tumor biopsies were immunohistochemically investigated for expression of p 53 , Bcl 2 , Bax ( bcl 2 associated 10 protein ) , and Bcl 10 ( L ) ( bcl 2 related 10 protein ) . ^^^ The overall expression of p 53 , Bcl 2 , Bax , and Bcl 10 ( L ) was 52 . 6 , 57 . 9 , 100 , and 97 . 4 % respectively . ^^^ Additionally , a more favorable outcome was observed in tumors positive for Bcl 2 ( not significant ) , whereas no differences in survival were observed in relation to the expression of Bax or Bcl 10 ( L ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Since the role of the Bcl 2 gene family has been only poorly investigated in colorectal cancer , we have examined the expression of the apoptosis blockers Bcl xL and Bcl 2 , as well as the proapoptotic factors Bax and Bak . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Immunohistochemical analysis of Bcl 2 , Bax , Bcl 10 , and Mcl 1 expression in pancreatic cancers . ^^^ We found that Bcl 2 was expressed in 23 % , Bax in 53 % , Bcl 10 in 90 % , and Mcl 1 in 90 % of the invasive ductal adenocarcinomas . ^^^ In intraductal papillary mucinous adenocarcinomas , the expression rate of Bax was 44 % and those of Bcl XL and Mcl 1 were 88 % ; these values were higher than those for intraductal papillary mucinous adenomas . ^^^ These results suggest that an imbalance between antiapoptosis proteins ( such as Bcl 2 , Bcl XL , and Mcl 1 ) and proapoptotic proteins ( such as Bax and Bcl Xs ) is involved in the distinctive biologic features of adenocarcinomas of the pancreas . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Two colour cytometric analysis of permeabilized CD34+ cells stained with antibodies to Bcl 2 , Bcl 10 ( anti apoptotic ) , Bax and Bad ( pro apoptotic ) , demonstrated significantly higher ratios of pro 5 anti apoptotic proteins in early MDS ( 2 . 47 ( 1 . 19 9 . 42 ) compared to advanced disease ( 1 . 14 ( 0 . 06 3 . 32 ) , P=0 . 0001 ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Although BAX and BCL 2 expression was similar among the three cell lines , the expression of the anti apoptotic protein , BCL 10 ( L ) , was significantly lower in S 1 cells than in S 3 and DCT cells , and this may have contributed to the heightened sensitivity of S 1 cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Apoptosis regulatory proteins include those that block apoptosis such as Bcl 2 and Bcl 10 , whilst a related protein Bax promotes apoptosis . ^^^ Paraffin embedded samples from ten different lesions of squamous cell carcinoma ( SCC ) , Bowen ' s disease ( BD ) , keratoacanthomas ( KA ) , and nine normal adult skin samples were stained by immunohistochemistry to detect expression of Bcl 2 , Bcl 10 , Bax , Ki 67 , p21wafl , p 53 and apoptosis ( TUNEL assay ) . ^^^ In contrast , by examining serial sections both Bcl 10 and Bax appeared to be coexpressed by the majority of malignant KCs in KA and SCC ( > 70 % ) . ^^^ These immunostaining profiles reveal that squamoproliferative lesions , including invasive transformed KCs , preferentially express Bcl 10 over Bcl 2 , in addition to upregulating their Bax levels . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Hypothesizing that loss of basal cells in oral lichen planus is due to apoptosis , we evaluated LP specimens for apoptosis regulating proteins [ positive regulators Bcl xS , Bax , Fas / Fas ligand , p 53 , and negative regulators ( anti apoptotic ) Bcl 2 , Bcl xL and compared results with reactions in normal mucosa and chronically inflamed gingiva . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Expression of bcl 2 , bcl 10 , bax and bak in renal parenchyma , oncocytomas and renal cell carcinomas . ^^^ Expression of bcl 2 , bcl 10 , bax and bak was investigated by immunohistochemistry and Western blotting of regular and alterated renal parenchyma as well as in 57 renal cell carcinomas . ^^^ Bcl 2 , bcl 10 and in part bax were found to be overexpressed in inflammed renal parenchyma , whereas atrophic tubuli predominantly stained for bcl 2 and to a lesser degree for bcl 10 and bax . ^^^ Moderate to strong expression for bcl 2 , bcl 10 , bax and bak was found in 24 , 38 , 2 and 13 of 57 carcinomas , respectively . ^^^ Bcl 2 , bcl 10 , bax and bak expression were correlated to tumor type . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Since Bcl xL can form an ion channel in synthetic lipid membranes , the possibility that this property has a role in heterodimerization independent cell survival was tested by replacing amino acids within the predicted channel forming domain with the corresponding amino acids from Bax . ^^^ Similar to mammalian cells undergoing apoptosis , yeast cells expressing Bax exhibited changes in mitochondrial properties that were inhibited by Bcl xL through heterodimerization dependent and independent mechanisms . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
OBJECTIVE : The purpose of this study was to determine whether there is an increase in expression of bcl 2 and related bcl 2 gene family members bcl 10 and bax in liver biopsy samples obtained from patients with either hepatitis C infection or cirrhosis . ^^^ Bcl 2 , bcl 10 , and bax , as well as other bcl 2 related proteins , function coordinately through homo and heterodimerization to regulate apoptosis . ^^^ METHODS : Sections cut from archived liver biopsy samples embedded in paraffin were probed with antibody specific for bcl 2 , bcl 10 , or bax . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
During this process , IL 6 downregulated expression of BCL 2 in 1A9 M cells and stimulated BCL XL expression , but had no effect on p 53 , Bax , or Bak gene expression . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In comparison with A 1 , Bcl 2 was expressed at low levels and was up regulated by monocytes only at 21 h , while neither Bax nor Bcl xL levels were altered by monocytes . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
At 10 9 M to 10 7 M , LPA and S1P significantly suppressed cellular levels of the apoptosis promoting protein Bax , without altering the levels of Bcl xL or Bcl 2 assessed by Western blots and immunoassays . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
There was no correlation between the susceptibility to gemcitabine and the endogenous expression of the B cell lymphoma 2 ( BCL 2 ) family proteins BCL 2 , BCL XL , myeloid cell leukemia 1 ( MCL 1 ) , BCL 2 associated 10 protein ( BAX ) , BCL 2 homologous antagonist / killer ( BAK ) and BCL XS . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Nonetheless , there were no significant alterations in levels of immunoreactive Bcl 2 , Bcl 10 ( L ) , Bax , Bad , and Bak , nor any evidence of cytochrome c release into cytosol and dissipation of delta ( psi ) m . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We find that ( 1 ) Bax ( delta ) is as efficient as full length Bax in promoting cytochrome c release , but Bcl 10 ( L ) delta has remarkably reduced rescuing ability compared to full length Bcl 10 ( L ) ; ( 2 ) full length Bcl 10 ( L ) protein acts by relocalizing Bax from the mitochondrial fraction to the soluble cytosolic fraction ; ( 3 ) Bax undergoes N terminal cleavage when expressed in yeast , which is prevented by coexpression of Bcl 10 ( L ) , suggesting that Bcl 10 ( L ) may mask the cleavage site of Bax through a direct physical interaction of the two proteins . . ^^^ Role of the C terminal domain of Bax and Bcl XL in their localization and function in yeast cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Whereas Fas ligand / Fas and tumor necrosis factor ( TNF ) alpha / TNF receptor 1 levels were not altered by NOS 2 deficiency , transcript levels for p 53 were significantly lower in grafts from NOS 2 / recipients , coinciding with a significant increase in the antiapoptotic Bcl 2 / Bax balance and decrease in Bcl Xl levels . ^^^ When NOS 2 is present , p 53 might control NOS 2 mediated apoptosis by stimulating Bax and repressing Bcl 2 and Bcl Xl expression , which may activate the cell death program in the rejecting heart . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Prognostic significance of Bcl 2 , Bcl xL / S , Bax and Bak expressions in colorectal carcinomas . ^^^ The immunohistochemical expressions of the apoptosis related proteins Bcl 2 , Bcl xL / S , Bax and Bak were investigated in tumor specimens selected from 58 consecutive patients undergoing surgery for advanced colorectal carcinoma . ^^^ In the normal colonic mucosa , Bcl 2 positive epithelial cells tended to be located at the base of the crypts , while the Bcl xL / S , Bax and Bak positive epithelial cells tended to be located at the luminal surface . ^^^ The intracellular expression patterns of Bcl 2 and Bax were diffuse cytoplasmic , whereas those of Bcl xL / S and Bak were granular cytoplasmic . ^^^ In the adenocarcinomas , the intracellular expression patterns of all antibodies were diffuse cytoplasmic , and the percentages of Bcl 2 , Bcl xL / S , Bax and Bak positive cases ( > 20 % of cancer cells labeled ) were 29 % , 43 % , 45 % and 69 % , respectively . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Immunohistochemical staining for BCL 2 , BCLX , BAX , and p 53 was performed in 7 pediatric low grade gliomas ( LGGs ) and 7 pediatric HGGs . ^^^ Similar BAX and BCLX protein expression was observed in LGG and HGG . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Biophysical characterization of the oligomeric state of Bax and its complex formation with Bcl XL . ^^^ Furthermore , several binding assays demonstrated that Bcl XL , an anti apoptotic member of the Bcl 2 family , can bind to the oligomeric form of Bax without requiring Bax to dissociate to monomers . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
All these events are prevented by p27Kip1 overexpression . p27Kip1 does not modulate Bcl 2 , Bcl 10 ( L ) , Mcl 1 and Bax protein level in leukemic cells but suppresses Mcl 1 expression decrease observed in mock transfected U 937 cells undergoing etoposide induced cell death . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
MycN overexpression and cytotoxic drugs also synergized to induce p 53 and Bax protein expression , while Bcl 2 and Bcl 10 ( L ) protein levels remained unchanged . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The fivefold elevation in steady state Bcl 2 concentration is not accompanied by detectable changes in the levels or cellular distributions of the related anti apoptotic regulator Bcl xL or of the proapoptotic regulators Bax and Bak and does not produce detectable effects on basal proliferation , differentiation , or death programs . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Cytofluorographic analysis and RT PCR reveal that MEC 1 and MEC 2 overexpress Bcl 2 together with Bax , express large amounts of Bcl xL and trace amounts of Bcl xS . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Exposure of endothelial cells to hypoxia did not alter levels of proapoptotic and antiapoptotic Bcl 2 family members Bax and Bcl XL by immunoblot analysis . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Analyses of apoptosis and of the apoptosis regulatory proteins Bcl 2 , Bax , Bcl 10 , and Bad were done in 95 nontumorous and neoplastic pituitary tissues by terminal deoxynucleotide transferase mediated dUTP nick end labeling ( TUNEL ) , immunohistochemistry , and Western blotting . ^^^ The lowest levels of Bcl 2 , Bax , and Bcl 10 expression were in pituitary carcinomas as detected by immunostaining . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The Bax conformational change is prevented by Bcl 2 and Bcl xL but not by caspase inhibitors . ^^^ Bcl xL can inhibit the effect of Bid by interacting directly with Bax . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
However , there was no difference between the two cell lines in the expression of Bcl 2 family proteins Bcl 2 , Bcl XL , Bcl XS , Bad , and Bax at the whole cell level , as analyzed by Western blotting . ^^^ Although the proapoptotic proteins Bcl XS , Bad , and Bax were mainly located in the cytosol , CEM / VLB100 mitochondria expressed higher levels of these proapoptotic proteins . ^^^ However , after exposure to TNF alpha , Bax , Bad , and Bcl XS translocated from the cytosol to the mitochondria of both cell lines . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In addition , the expression of MCL 1 , an antiapoptotic member of the BCL 2 family , is downregulated during Na Sal induced cell death , whereas the expression of BCL 2 , BAX , and BCL XL is unchanged . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Immunohistochemistry was performed to examine the expression of CD 3 , CD 20 , PCA 1 , CD 40 , CD40L , Bcl 2 , Bax , and Bcl 10 on T and B lymphocytes infiltrating labial salivary glands of SS patients . ^^^ Bcl 10 was also abundantly expressed on infiltrating mononuclear cells , but , Bax expression was relatively less than that of Bcl 2 or Bcl 10 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
C6tk cells constitutively express Bcl xL and Bax proteins ; when exposed to GCV , Bcl xL levels do not change but Bax accumulation is rapidly induced . ^^^ These findings suggest that the balance between Bcl xL and Bax proteins may be of importance in determining the sensitivity of tumoral cells to GCV . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Thus , both protective factors ( e . g . , Bcl 2 and Bcl xL ) and factors that promote hepatocyte death by apoptosis ( e . g . , Bax ) or necrosis ( e . g . , UCP 2 ) may be increased in fatty livers . ^^^ Immunohistochemistry showed striking induction of hepatocyte proteins that promote ( e . g . , Bax ) and inhibit ( e . g . , Bcl 2 and Bcl xL ) apoptosis in both groups with fatty liver . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Therefore , we examined the expression of the Bcl 10 and Bax genes , which are known to synergize and antagonize Bcl 2 , respectively . ^^^ With the exception of anaplastic tumor W 17 , the monotony of Bcl 10 and Bax mRNA levels did not suggest that the expression of these apoptosis regulating genes could have a role in the prognosis of nephroblastoma . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
It was found that VD 3 significantly induced the expression of Bcl 2 messenger RNA and protein in thyrocytes but had no effect on the expression of Bcl xl and Bax . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
This study examined the relationship between blastomere fragmentation in cultured human embryos obtained by in vitro fertilization and the effect of fragmentation on the distribution of the following eight regulatory proteins found to be : ( 1 ) localized in the mature oocyte in subplasmalemmal , polarized domains ; and ( 2 ) unequally inherited by the blastomeres during cleavage : leptin , signal transducer and activator of transcription 3 ( STAT 3 ) , Bax , Bcl 10 , transforming growth factor beta 2 ( TGF beta 2 ) , vascular endothelial growth factor ( VEGF ) , c kit and epidermal growth factor R ( EGF R ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Peripheral blood eosinophils were found to express constitutively Bax and Bcl 10 , but Bcl 2 was absent . ^^^ Culturing eosinophils in the presence of 100 pg / ml IL 5 for 24 h significantly reduced apoptosis ( P < 0 . 01 ) to 10 . 7 + / 2 . 6 % compared with 46 . 8 + / 7 . 4 % in the absence of IL 5 , and induced Bcl 2 mRNA and protein expression , with no detectable change in Bax , Bcl 10 , or beta actin as a control . ^^^ To investigate the role of such proteins in the regulation of apoptosis of eosinophils , the expression of Bcl 2 and homologues Bcl xL ( death antagonists ) , Bax , and Bcl xS ( death agonists ) were examined by immunoblot , flow cytometry , and reverse transcriptase polymerase chain reaction analysis . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Derangements in cell cycle control and apoptosis regulation might be responsible for the progression from metaplasia to dysplasia and adenocarcinoma We tested this hypothesis by performing cell cycle analysis , in situ detection of apoptosis , and evaluation for the immunohistochemical expression of proteins involved in proliferation ( Ki 67 ) , the control of apoptosis ( bcl 2 , bcl 10 and bax ) , and cell cycle regulation ( retinoblastoma and cyclin D 1 ) . ^^^ A statistically significant linear association was found between bcl 10 expression , bax expression , and the bcl 2 to bax expression ratio versus increasing histologic severity ( P = . 0004 , P = . 007 , and P = . 03 , respectively ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Apoptosis and expression of Bax , Bcl 10 , and Bcl 2 apoptotic regulatory proteins in colorectal carcinomas , and association with p 53 genotype / phenotype . ^^^ AIMS : Spontaneous apoptosis and expression of the apoptotic regulatory proteins Bax , Bcl 10 , and Bcl 2 were investigated in 50 colorectal carcinomas . ^^^ Staining intensities for Bax , Bcl 10 , and Bcl 2 were strong ; that is , equivalent to or greater than positive normal mucosal cells , in 11 of 50 , 20 of 49 , and 20 of 48 carcinomas . ^^^ Bax , Bcl 10 , and Bcl 2 protein expression were not correlated with tumour apoptosis or tumour DNA ploidy status . p 53 was expressed in 34 of 50 tumours and p 53 gene mutations were detected in 22 of 29 p 53 positive tumours analysed . ^^^ Bax and Bcl 10 protein expression were not significantly associated with p 53 phenotype / genotype . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
METHODS : Immunohistochemistry was performed on tissue sections using antibodies against bcl 2 , bcl 10 , bax , and bak . ^^^ Both bcl 2 and bax were diffusely cytosolic whereas bcl 10 and bak exhibited a distinct perinuclear distribution . ^^^ The distribution of bcl 10 and bax proteins within BCC and SCC overlapped and were associated with squamous differentiation . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Using quantitative Western blotting we have determined the level of expression of BCL 2 , BAX , MCL 1 , and BCL 10 in lymphoblasts from 47 children with ALL ( 33 at presentation only , 4 at relapse only , and 10 at both presentation and on relapse ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Furthermore , the antiapoptotic Bcl 2 and Bcl XL proteins can protect yeast against Bax mediated lethality , suggesting that the death regulatory functions of these Bcl 2 family proteins are well preserved in yeast . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
This review summarizes the recent initial studies on the in vitro channel activity of Bcl 2 , Bcl XL and Bax and offers some speculation as to the physiological role that these channels may play in the cell death pathway . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Developmental expression patterns of Bcl 2 , Bcl 10 , Bax , and Bak in teeth . ^^^ The ontogenic profile of expression of four members of the Bcl 2 family ( Bcl 2 , Bcl 10 , Bax and Bak ) was examined in the mouse by immunohistochemistry using paraffin sections . ^^^ In general , contemporaneous co expression of the Bcl 2 and Bax proteins , and of the Bcl 10 and Bak proteins was noted in various types of cells during the developmental process , with the intensity of Bcl 2 > Bax and of Bak > Bcl 10 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Sodium butyrate does not increase Fas receptor cell surface expression and does not modify cell levels of Bcl 2 , Bcl xL , Bcl xS and Bax . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In this paper , we have further characterized the sensitive and resistant phenotypes and investigated whether a different expression of the apoptotic genes Fas , FasL , Bcl 2 , Bcl 10 and Bax is involved in the regulation of Dex mediated apoptosis . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Here we demonstrate that inhibition of the epidermal growth factor receptor tyrosine kinase activity with either an epidermal growth factor receptor antagonistic monoclonal antibody ( MoAb 425 ) or an epidermal growth factor receptor selective tyrosine kinase inhibitor ( AG 1478 ) downregulated Bcl 10 ( L ) expression in normal human keratinocytes but had no effect on expression of the pro apoptotic Bcl 2 homologs Bad , Bak , and Bax . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
RESULTS : The infection and apoptosis of CEM cells were associated with enhanced expression of Bax , Bcl 2 , Bcl 10 ( L ) and caspase 1 ( ICE ) . ^^^ The CD 8 cells of HIV infected individuals exhibited increased expression of Bcl 2 , Bcl 10 ( L ) , Bax and caspase 1 but , in contrast to the CD 4 subset , they showed elevated expression of p21CIP1 and p16INK4a compared with controls . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Furthermore , the ratio of expression of the pro apoptotic bax gene to the anti apoptotic bcl 2 gene was reduced in bcl 10 deficient cultures grown in ITS , suggesting that the interaction between these bcl 2 family members may , in part , regulate a Bcl xL independent survival pathway . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Moreover , addition of endostatin led to a marked reduction of the Bcl 2 and Bcl XL anti apoptotic protein , whereas Bax protein levels were unaffected . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We studied the substantia nigra of three Parkinson ' s disease ( PD ) patients and three age matched individuals by in situ DNA end labeling ( ISEL ) and immunohistochemistry for the apoptosis regulating proteins Bcl 2 , Bax and Bcl 10 on 50 consecutive sections per patient . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We examined the expression of the bcl 2 family oncoproteins bax , bak , bcl 2 , bcl xL , and mcl 1 in the course of differentiation of human keratinocytes cultured at low ( 0 . 15 mM ) and high ( 1 . 87 mM ) calcium concentrations . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Ninety archived paraffin embedded specimens from 25 patients ( two or more sequential biopsies each ) and eight control specimens were evaluated in immunohistochemically stained sections for tumor suppressor protein p 53 , p 53 binding protein mdm 2 , and apoptosis regulatory proteins Bcl 2 , Bcl 10 , Bax , and Bak . ^^^ These data show that apoptosis associated proteins are altered in variable patterns in both premalignant and malignant oral epithelial lesions . p 53 and especially Bak and Bcl 10 are expressed early ; Bax is largely absent ; and Bcl 2 and mdm 2 show sporadic expression in the development of oral premalignant and malignant disease . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bax , Bcl 10 and CPP 32 immunoreactivity were increased in facial motoneurons after axotomy . ^^^ We have examined , in situ , the influence of Bcl 2 over expression on the messenger RNA level of two pro apoptotic , bax and cpp 32 , and one anti apoptotic , bcl xl , regulators of neuronal death . ^^^ No changes in bax and bcl xl messenger RNAs expression were detected . ^^^ In adult wild type mice no motoneuron death was detected one week after axotomy : bax and cpp 32 messenger RNAs were increased and bcl xl messenger RNA was decreased . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
PURPOSE : The prognostic significance of spontaneous levels of apoptosis and Bcl 2 , Bax , and Bcl 10 protein expression in follicular center lymphoma ( FCL ) is unknown . ^^^ The objectives of this retrospective study were ( 1 ) to investigate the relationship between pretreatment apoptosis levels and long term treatment outcome in patients with Stage 1 and 2 FCL ; ( 2 ) to define the incidence and patterns of Bax and Bcl 10 protein expression in human FC ; and ( 3 ) to determine the relationship of Bcl 2 , Bax , and Bcl 10 expression with spontaneous apoptosis levels and clinical outcome in localized FCL . ^^^ Expression of Bcl 2 , Bax , and Bcl 10 proteins was assessed using immunohistochemistry . ^^^ Positive staining of tumor follicles was observed in 96 % of cases for both the Bax and Bcl 10 proteins . ^^^ Expression of Bcl 2 , Bax , or Bcl 10 did not correlate with AI or clinical outcome . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Left ventricular tissue from separate groups of animals ( n = 5 per group ) , 24 hours after pretreatment with phenylephrine or vehicle but without ischemia and reperfusion , was analyzed by Western blotting for content of the anti apoptotic protein , bclx , and pro apoptotic protein , bax . ^^^ Analysis by Western blotting showed that the ratio of bclx to bax protein increased in phenylephrine pretreated hearts ( 2 . 65 + / 0 . 5 vs 1 . 0 + / 0 . 1 for vehicle , P = . 008 ) . ^^^ CONCLUSION : Delayed myocardial protection to infarction mediated by alpha 1 adrenoceptor activation involves an increased bclx / bax ratio , thereby limiting apoptotic cell death . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Western blotting analysis showed that sequential treatment ( MALD / TPA ) increased Bcl 2 oncoprotein expression , whereas Bcl XL and Bax proteins were not changed . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The Bcl 2 family members Bcl 2 and Bcl xL suppress programmed cell death , whereas Bax promotes programmed cell death . ^^^ An increase in Bcl 2 but not Bcl xL or Bax , cleavage of caspase 1 , up regulation and cleavage of caspase 3 , and evidence for DNA fragmentation with both apoptotic and necrotic morphologies were found in tissue from traumatic brain injury patients compared with controls . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Act D treatment of AIDS KS cells markedly and selectively down regulated Bcl xL expression , while the expressions of decoy receptors 1 and 2 , Bax , cellular FLICE ( Fas associated death domain protein like IL 1 converting enzyme ) inhibitory protein , FADD ( Fas associated death domain protein ) , procaspase 8 , and p 53 were not affected . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Mediated by GAPDH binding , DES increases mitochondrial BCL 2 and BCL xL levels and decreases BAX levels thereby preventing the permeability transition pore ( PTP ) form opening and preventing apoptotic degradation . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bax and Bcl 10 were evenly expressed throughout development . ^^^ Thus , the pro apoptotic proteins Bax , Bak and Bad , as well as the death suppressors Bcl 10 , Bcl 2 and Bcl w , are synthesised in mouse mammary gland , and dynamic changes in the expression profiles of these proteins occurs during development . ^^^ In extracts of mammary tissue in vivo , Bak heterodimerized with Bcl 10 whereas Bax associated with Bcl w , but Bak / Bcl w heterodimers were not detected . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bax , but not Bcl xL , decreases the lifetime of planar phospholipid bilayer membranes at subnanomolar concentrations . ^^^ We used planar phospholipid membranes to test the effect of full length Bax and Bcl xL synthesized in vitro and native Bax purified from bovine thymocytes . ^^^ Instead of forming pores with reproducible conductance levels expected for ionic channels , Bax , but not Bcl xL , created arbitrary and continuously variable changes in membrane permeability and decreased the stability of the membrane , regardless of whether the source of the protein was synthetic or native . ^^^ Bcl xL did not protect against Bax induced membrane destabilization , supporting the idea that these two proteins function independently . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Using RT PCR it was shown that mRNA for several modulators of apoptosis ( Fas , Bcl 2 , Bcl xl , Bax , and ICE ) are expressed by both cell lines and ex vivo tissues . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
A novel protein , Btf ( Bcl 2 associated transcription factor ) , that interacts with E1B 19K as well as with the antiapoptotic family members Bcl 2 and Bcl xL but not with the proapoptotic protein Bax was identified . btf is a widely expressed gene that encodes a protein with homology to the basic zipper ( bZip ) and Myb DNA binding domains . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In this lesion we identified apoptosis of vascular smooth muscle cells ( VSMCs ) by in situ DNA labelling and electron microscopy in the neointima on the 14th day after injury . mRNA expression levels of bcl 2 , bax , bcl 10 , p 53 and caspase 1 were determined by the reverse transcriptase polymerase chain reaction method both in injured and uninjured carotid arteries . ^^^ Neither bcl 2 nor bcl xl mRNA expression was detected in either injured or uninjured arteries , whereas bax and p 53 mRNA expression was identified and their mRNA levels were not altered after balloon injury . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Cpp 32 , Bax and Bcl xl are regulators of this type of cell death in the central nervous system . ^^^ Using in situ hybridization , we have studied the kinetics of expression of cpp 32 , bax and bcl xl mRNAs after a fatal lesion of the facial nerve in wild type and Bcl 2 transgenic mice , where cell death is known to be prevented . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In the IO , increased expression of bax in neurons and bcl 10 in astrocytes after 3AP was significantly reduced by IGF 1 treatment . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The beta 2 adrenoceptor agonist clenbuterol modulates Bcl 2 , Bcl xl and Bax protein expression following transient forebrain ischemia . ^^^ Bcl 2 , Bax and Bcl xl proteins were detectable in the non ischemic hippocampus and the striatum . ^^^ Bcl 2 was up regulated in both detected regions at 24 h after ischemia , while the increase in Bax and Bcl xl protein expression had appeared already at 6 h and also 24 h after ischemia . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The expression of Bcl 2 family proteins ( Bcl 2 , Bcl 10 , Bcl XL , Bcl Xs , BAX , BAD , MCL 1 ) and of Interleukin 1 converting enzyme ( ICE ) related proteins ( ICE , CPP 32 , ICH 1 ) was analyzed in acute leukemia cells by flow cytometry . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In the second set of experiments , expression of bax and bcl 10 in CL after in vitro treatment without and with 100 U / ml SOD was examined . ^^^ Although SOD treatment did not alter the levels of bcl 10 messenger RNA ( mRNA ) over the 2 h incubation period , this antioxidant enzyme significantly reduced the levels of bax mRNA in incubated CL . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
There was no evidence showing that changes in the expressions of Bcl 2 , Bcl xL , Bak , and Bax lead directly to IFN alpha mediated apoptosis . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Nerve growth factor determines survival and death of PC 12 cells by regulation of the bcl 10 , bax , and caspase 3 genes . ^^^ NGF withdrawal resulted in abrupt down regulation of bcl xl and up regulation of bax , favoring apoptosis . ^^^ These results indicate that Bcl xl , Bcl xs , Bax , and caspase 3 are important regulators of apoptosis in PC 12 cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Western blot analysis for Bcl 2 family of proteins showed that Bax was expressed at a 2 . 2 times lower level in 11ad cells than in KHM 11 cells while there was no difference in expression of Bcl 2 , Bcl Xs nor Bcl XL . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The levels of other BCL 2 family members including BAX , BCL 2 , BCL 10 or MCL 1 were not consistently modulated by mutant or wild type p53val135 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
METHODS : Primary bovine glomerular endothelial cells were stimulated with TNF alpha or LPS , and apoptotic cell death was investigated by DNA fragmentation analysis , morphological studies , measurement of cytochrome c efflux and mitochondrial permeability transition , Bak , Bad , Bax , Bcl 2 , Bcl xL protein expression , and caspase 3 like protease activity . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Recent results from our laboratory have indicated that ischaemia induced acute renal failure is associated with up regulation of two anti apoptotic Bcl 2 proteins ( Bcl 2 and Bcl XL ) in the damaged distal tubule and occasional up regulation of Bax in the proximal tubule . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
During the induction of apoptosis by phloretin , the expression of Bax protein in B 16 cells increased and the levels of p 53 , Bcl 2 , and Bcl XL proteins did not change . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Here we create liposomes that carry the mitochondrial porin channel ( also called the voltage dependent anion channel , or VDAC ) to show that the recombinant pro apoptotic proteins Bax and Bak accelerate the opening of VDAC , whereas the anti apoptotic protein Bcl 10 ( L ) closes VDAC by binding to it directly . ^^^ Bax and Bak allow cytochrome c to pass through VDAC out of liposomes , but passage is prevented by Bcl 10 ( L ) . ^^^ In agreement with this , VDAC 1 deficient mitochondria from a mutant yeast did not exhibit a Bax / Bak induced loss in membrane potential and cytochrome c release , both of which were inhibited by Bcl 10 ( L ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In addition , Bcl 2 also prevented the increase in cellular levels of Bak , Bax and Bcl xL , along with degradation of actin and Bax . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Co treatment did not significantly alter Bcl 2 , Bcl xL , Bax or Fas receptor ( FasR ) , but modestly increased Fas ligand ( FasL ) protein . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Among them , bcl xl and bax , which encode for antiapoptotic and proapoptotic proteins , respectively , play major roles during development . ^^^ To gain insight into the possible implications of these cell death genes during the postnatal development , we investigated the expression of bax , bcl xl , and cpp 32 mRNAs by in situ hybridization in the mouse brain from birth to adulthood . ^^^ Whereas bax and bcl xl mRNAs were expressed widely in neonates and adult mice , our results showed that cpp 32 mRNA levels were decreased strongly from 12 postnatal days . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Downregulation of Bcl 2 , but not of Bax or Bcl 10 , is associated with T lymphocyte apoptosis in HIV infection and restored by antiretroviral therapy or by interleukin 2 . ^^^ The role of Bcl 2 , Bax , and Bcl 10 in the apoptosis of T lymphocytes in HIV infected individuals was investigated . ^^^ In contrast to Bcl 2 , no correlation is detectable between Bax or Bcl 10 expression and apoptosis . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Exposure of undifferentiated U 937 cells to 50 microM etoposide for 6 h , that triggers apoptosis in 80 % cells , activates procaspase 2L , 3 and 8 , induces the mitochondrial release of cytochrome c and decreases Mcl 1 expression without modifying Bcl 2 , Bcl xL and Bax protein levels . ^^^ Exposure of TPA differentiated U 937 cells to 0 . 8 microg / ml cycloheximide for 24 h , that triggers apoptosis in 50 % cells , activates procaspase 2L , 3 and 8 , induces the mitochondrial release of cytochrome c and decreases Bcl xL expression without modifying Bcl 2 , Mcl 1 and Bax protein levels . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bcl 2 , Bax and Bcl 10 expression following kainic acid administration at convulsant doses in the rat . ^^^ To assess the involvement of members of the Bcl 2 family in cell death or survival , immunohistochemistry , western and northern blotting to Bcl 2 , Bcl 10 and Bax , and in situ hybridization to Bax were examined at different time points after kainic acid treatment . ^^^ Dying neurons in the pyramidal cell layer of CA 1 and CA 3 areas , entorhinal and piriform cortices , and amygdala also expressed Bcl 2 , Bax and Bcl 10 following excitotoxicity , although many dying cells did not . ^^^ Western blots disclosed no modifications in the intensity of the bands corresponding to Bcl 2 , Bcl 10 and Bax , between control and kainic acid treated rats . ^^^ The present results suggest that cell death or survival does not correlate with modifications of Bcl 2 , Bax and Bcl 10 protein , and messenger RNA expression , but rather that kainic acid excitotoxicity is associated with Bax translocation to the nucleus in a subset of dying cells . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The expression of the mitochondrial factors Bcl 2 , Bcl 10 , and Bax was determined because each has been implicated in the regulation or release of cytochrome c at the level of the mitochondria . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The expression of the pro apoptotic proteins ( Bax , Bak ) and anti apoptotic proteins ( Bcl 2 , Bcl 10 , Mcl 1 ) was studied by immunohistochemistry in 110 invasive ductal breast carcinomas . ^^^ Overall , Bcl 2 , Bcl 10 , Mcl 1 , Bax , Bak , ER , and p 53 were detected in 62 , 75 , 68 , 75 , 60 , 68 and 26 per cent of the cases respectively , but at different levels in each case . ^^^ No correlation was found between the apoptotic index and Bax , Bcl 10 , and Mcl 1 immunostaining results . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Overexpression of the anti apoptotic bcl xL transcript and the pro apoptotic bax mRNA was also detected but no alterations in bcl 2 or bag 1 mRNA levels were observed . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
After infection with AxCA p 53 , the expression levels of bax or bcl XL protein changed in MKN 1 , but not in the other cell lines . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Deletion of the C terminal of bax ( baxDeltaC ) or exchanging the C terminal ends of bax and bcl XL suggests that the bax C terminus is not an addressing / anchoring signal . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The aim of the present study is to clarify ( 1 ) whether cardiac apoptosis occurs during the transition from compensated hypertrophy to decompensated heart failure , and ( 2 ) whether expression of the genes encoding Bax ( an apoptosis inducer ) and Bcl xL and Bcl 2 ( apoptosis inhibitors ) is altered during this transition . ^^^ The expression of bcl 2 , bcl xL and bax was analysed by Northern blotting . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The incidence of apoptotic nuclei ( < 1 % ) as evidenced by the terminal deoxynucleotidyl transferase mediated dUTP nick end labeling ( TUNEL ) method , and the histological distribution of immunoreactive Bcl 2 , Bax , and Bcl 10 proteins , were similar in placentae collected after delivery and before the onset of labor and in placental explants maintained overnight at 4 degrees C in a minimal salt Hepes medium . ^^^ This marked increase was associated with a decrease in the intensity of the Bcl 2 immunostaining and an increase in the intensity of Bax and Bcl 10 immunostaining . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
No significant changes in Bcl 2 , BclX , and Bax protein expression level were observed in the transfected clones as compared with the control H 460 cells whereas a 2 fold increase in Bak protein levels was noticed . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
This effect was specific to bcl 2 , as expression of other members of the bcl 2 family ( bax , bcl 10 ( L ) , bcl 10 ( S ) , and bad ) was unaffected by estradiol treatment . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We tested an unselected panel of 11 melanoma cell lines for sensitivity to CD 95 and the corresponding expression of CD 95 , CD95L , bcl 2 , bcl 10 , bcl xS , bax and FLIP proteins . ^^^ Apoptosis related proteins CD95L , bcl 2 , bcl 10 , bcl xS and bax were found to be heterogenously expressed in different melanoma cell lines tested . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Mammary gland tissue , similar to many other tissues , expresses a number of different Bcl 2 relatives including bcl 10 , bax , bak , bad , bcl w , bfl 1 , bcl 2 as well as the bcl 2 binding protein Bag 1 . ^^^ In contrast , expression of bcl 10 and bax continues through late pregnancy , is down regulated during lactation , and upregulated with the start of involution . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Transcript levels of c erbB 2 , p 53 , p 21 , GADD 45 , bax , bcl 10 , mcl 1 , and c fos were also unaffected by EMF exposure . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Examination of expression levels of Bcl 2 protoncogene family members ( Bcl 2 , Bcl 10 ( L ) , Mcl 1 , and Bax ) showed a downregulation of Bcl 10 ( L ) and Mcl 1 after CD 22 ligation . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In this study , the expression of four apoptosis related proteins ( bcl 2 , bcl 10 , bax and p 53 ) in 53 cases of HD was examined and the data were correlated with the genotype , the EBV status and the phenotype ( B , T or null ) of the neoplastic cells . ^^^ The H RS cells were bcl 2 positive in 19 / 53 ( 36 % ) , bcl 10 positive in 17 / 53 ( 32 % ) , bax positive in 1 / 53 , and p 53 positive in 41 / 53 ( 77 % ) cases . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Differential distribution of presenilin 1 , Bax , and Bcl 10 ( L ) in Alzheimer ' s disease and frontotemporal dementia . ^^^ To examine if this is also the case in other dementing conditions , and if it is associated with changes in the expression of the main apoptosis related proteins , a quantitative immunocytochemical study of presenilin 1 , Bax , and Bcl 10 ( L ) in the cerebral cortex of non demented and AD patients , and patients with frontotemporal dementia ( FTD ) was performed . ^^^ In non demented cases , the frequency of neurons showing PS 1 immunoreactivity was 25 60 % , Bax immunoreactivity 36 54 % , and Bcl 10 ( L ) immunoreactivity 26 63 % depending on the cortical area . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Acute first postnatal week ethanol exposure up regulated mRNA transcripts encoding the cell death promoting molecules bax and bcl xs as measured on P 4 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Moreover , we found that this effect is mediated in the absence of changes in expression of Bcl 2 , Bcl Xl , and the pro apoptotic protein Bax . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Endogenous Apaf 1 also failed to coimmunoprecipitate with endogenous Bcl 2 or Bcl 10 ( L ) , or with two proapoptotic relatives ( Bax and Bim ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Here , the expression of bcl 2 family members ( bcl 2 , bax , bad , and bcl 10 ( s / l ) ) and caspases 1 , 2 , 3 , 4 , and 6 was investigated through a range of stages of chick lens development using immunocytochemistry , Western blotting , and affinity labelling for caspases using biotinylated caspase inhibitors . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Cells overexpressing MnSOD contained less bcl 10 ( L ) within the mitochondria compared to control ( NEO ) cells , therefore excluding the role of bcl 10 ( L ) . p 53 was undetectable by Western analysis and examination of the proapoptotic protein bax , a p 53 target gene , did not increase with treatment . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
To study the possible roles of bcl 2 family proteins in oncogenesis and cytodifferentiation of odontogenic epithelium , the expression of bcl 2 , bcl 10 and bax proteins was examined immunohistochemically in tooth germs and various types of ameloblastoma . ^^^ In ameloblastomas , bcl 2 and bcl 10 proteins were expressed intensely in peripheral columnar cells and weakly in central polyhedral cells , while bax protein reactivity was low . ^^^ Basal cell ameloblastomas showed intense reactivity for bcl 2 and bcl 10 proteins , but slight or no reactivity for bax protein . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
With the combination , the expression of Bax and Bcl xS , the apoptosis enhancing proteins , was more up regulated and that of Bcl 2 and Bcl xL , the apoptosis suppressing proteins , was more down regulated compared to the use of EPA or TNP 470 alone , suggesting that their synergistic effect was due to an acceleration of apoptosis . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In this study , we demonstrate that constitutive expression of bcl xl but not bcl 2 , bcl xs , bak , bad , or bax was associated with apoptosis resistance after IL 2 deprivation in CTLL 2 cells that expressed Tax . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bcl xL and Bcl 2 were protective without any change in the level of endogenous Bcl xL or Bax and inhibited hepatic caspase 3 like activity . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The antiapoptotic protein bcl 2 was apparently up regulated in A549 / UCN cells , however , bcl xL , another antiapoptotic protein , was down regulated , without changes in bak and bax . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Studying the role of estrogen in DRG , we observed that low concentrations of 17beta estradiol increased survival of cultured DRG neurons deprived of nerve growth factor . 17beta Estradiol up regulated the expression of the antiapoptotic molecule Bcl 10 without affecting that of Bax , suggesting a mechanism by which the hormone counteracted neuronal death . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Unlike other proapoptotic Bcl 2 family members , such as Bax and Bak , Bcl 10 ( S ) does not seem to induce cell death in the absence of an additional death signal . ^^^ However , Bcl 10 ( S ) does interfere with the ability of Bcl 10 ( L ) to antagonize Bax induced death in transiently transfected 293 cells . ^^^ Deletion mutants of Bax and Bcl 2 , which lacked BH 1 and BH 2 domains but contained a BH 3 domain , were able to antagonize the survival effect conferred by Bcl 10 ( L ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The treatment of taxotere activated proapoptotic genes such as bcl Xs and bax genes . ^^^ The relationship between the mRNA induction of bcl Xs and bax genes and the internucleosomal DNA ladders by taxotere was significant , respectively ( p < 0 . 05 ) . ^^^ The introduction of bcl Xs gene into MKN 45 gastric cancer cells increased the sensitivity to VP 16 and taxotere 2 3 fold in the IC 50 values , whereas the introduction of bax gene increased the sensitivity to CDDP , VP 16 and taxotere 2 5 fold in the IC 50 values , as compared to that of the Neo transfected MKN 45 cells . ^^^ The mRNA overexpression of bax gene was found in the bcl Xs transfected cells . ^^^ Likewise , the mRNA overexpression of bcl Xs gene was also found in the bax transfected cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The decision between survival or death in response to an apoptotic stimulus is determined and regulated in part by oncoproteins which include proteins of the Bcl 2 family ( bcl 2 , bax , bcl xL ) and bcr abl . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Neither the expression of the anti apoptotic protein Bcl xL nor that of the pro apoptotic proteins Bax and Bak were altered in cells expressing mutated N Ras . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The expression of members of the Bcl 2 family of proteins , such as Bcl 2 , Bcl xL , Bax , and Bad , was unchanged by the overexpression of PHGPx in cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Intact plasmid DNAs were recovered by PCR amplification from the slices with bcl 2 or bcl 10 cDNAs but not from slices with empty vector or bax cDNA that promotes cell death . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The GnRH Ag induced decrease in the 18 kDa PBR protein also correlated with the reduction in the Bcl 10 ( L ) , but not Bcl 2 ( cell survival ) , gene product levels and the increase in the Bax ( cell death ) gene product expression in the luteal mitochondrial preparations . ^^^ Considering the function of PBR in cholesterol uptake and intramitochondrial movement , we propose that decreased PBR expression may lead to reduced levels of mitochondrial membrane cholesterol , which , together with the ability of Bcl 10 ( L ) and Bax to form ion channels , produces breaks in the outer membranes allowing the exit of cytochrome c , thus triggering apoptosis . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Expression of Bcl 2 and its homologues , Bcl xL , Bcl xS , Bax , Bad , Bak and Bag 1 , was detected in all NHL cases , with wide variations between histological subtypes and within each subtype . ^^^ When compared to NHL cells , normal B cells showed a higher level of Bax expression , and a lower level of Bcl xL expression . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In contrast to its effects on apoptosis , bryostatin 1 failed to restore paclitaxel mediated increases in free Bax levels in U937 / Bcl xL cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We have found that , in addition to Bcl 2 and Bax , the expression levels of apoptosis inducers ( Bad , Bak ) and inhibitors ( Bcl xL , Mcl 1 ) were highly variable in blasts from 78 children with newly diagnosed acute lymphoblastic leukemia ( ALL ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The expression of bcl 2 and bcl xL was higher and the expression of bax was lower in lower density cultures compared to higher density cultures at basal condition . ^^^ After incubation with stressors , bcl 2 and bcl xL expressions decreased and bax expression increased in both lower and higher density cultures . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Relative level of expression of Bax and Bcl XL determines the cellular fate of apoptosis / necrosis induced by the overexpression of Bax . ^^^ Upon simultaneous overexpression of the Bcl XL and Bax proteins in the U 251 cells , Bax induced apoptosis of U 251 cells was suppressed and an increase in the number of necrotic cells was seen . ^^^ If a cancerous cell expresses a level of Bcl XL which prevents Bax induced apoptosis , the overexpression of Bax leads to necrotic cell death . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
As Bcl 2 related proteins are involved in apoptotic process , we also evaluated their role by examining the expression of Bcl 2 , Bcl 10 ( L ) , and Bax on SEB FK 506 treated murine splenic T cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bcl 2 , Bcl 10 , Bax , and Bak expression in short and long lived patients with diffuse large B cell lymphomas . ^^^ The expression of the apoptosis regulating proteins , Bcl 2 , Bcl 10 , Bax , and Bak , in the initial biopsy samples was examined with immunohistochemical methods . ^^^ An inverse association was found between length of patient survival and expression of Bcl 2 , Bcl 10 , and Bax . ^^^ Several combinations of protein expression , i . e . , Bcl 2 with Bax , Bcl 2 with Bcl 10 , and Bcl 10 with Bax , were different between the groups : a positive expression of these proteins was found in the short lived patients . ^^^ In diffuse large B cell NHL , Bcl 2 , Bcl 10 , and Bax expression alone or in combination is associated with chemoresistance and shortterm survival . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Tamoxifen induced apoptosis in breast cancer cells relates to down regulation of bcl 2 , but not bax and bcl 10 ( L ) , without alteration of p 53 protein levels . ^^^ In this study , we investigated the effects of TAM on bcl 2 family gene products bcl 2 , bax , and bcl 10 ( L ) and on p 53 levels in estrogen receptor positive MCF 7 breast cancer cells . ^^^ TAM did not , however , affect bax , bcl 10 ( L ) , or p 53 expression at the mRNA or protein level . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Expression of p 53 also had no effect on the expression levels of proteins such as Fas , GADD 45 , Bax , Bcl 2 , Bcl 10 ( L ) or p 53 induced proteins ( PIGS ) in resting cells or after irradiation . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Using the GM CSF dependent TF 1 myeloid leukaemia cell line , the authors show that the endogenous levels of BCL 2 and MCL 1 are downregulated upon GM CSF withdrawal , whereas the levels of BCL 10 ( L ) and Bax are unchanged . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Expression of Bcl 2 , Bax , Bcl 10 , and Mcl 1 proteins and of the proliferation marker Ki 67 was evaluated by immunohistochemistry . ^^^ In tumors that had progressed from WHO Grade 3 anaplastic oligodendrogliomas , the authors found significantly more Bcl 10 positive ( P = 0 . 005 ) , Mcl 1 positive ( P = 0 . 002 ) , and Bax positive ( P = 0 . 03 ) cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Ginsenoside Rh 2 induces apoptosis independently of Bcl 2 , Bcl xL , or Bax in C6Bu 1 cells . ^^^ It was demonstrated that the expression of Bcl 2 , Bcl xL and Bax was not altered in ginsenoside Rh 2 treated C6Bu 1 cells . ^^^ These results suggest the existence of other apoptotic pathway that requires induction of apoptosis by ginsenoside Rh 2 rather than the pathway through Bcl 2 , Bcl xL or Bax in C6Bu 1 cells . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The ratio of the expression of Bcl 2 to Bax or Bcl xL to Bax , and XIAP expression in synovial cells may not be directly associated with the susceptibility of synovial cells to apoptosis by LLL CHO . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bcl 2 , bax and bcl xL expression in human sensitive and resistant leukemia cell lines . ^^^ Furthermore , the role of bcl 2 and bcl xL apoptosis inhibitors as well as bax expression ( apoptosis inducer ) in human sensitive leukemic cell lines ( CCRF CEM and HL 60 ) as compared to their resistant variants such as CCRF CEM / ACT400 , CCRF CEM / VCR1000 , HL 60 / IDA40 , HL 60 / DNR250 was evaluated . ^^^ Bcl 2 and bax were analyzed by both flow cytometry and ECL Western blot , bcl xL by ECL Western blot alone . ^^^ Comparison of the two sensitive cell lines demonstrated different bcl 2 , bax and bcl xL patterns . ^^^ The common characteristic of all resistant cell lines was the decreased expression of bax compared to bcl 2 or bcl xL . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In the present study , we characterized the regulation of antiapoptotic ( Bcl 2 , Bcl xL ) and proapoptotic ( Bad , Bax ) Bcl 2 family proteins in the rat heart during development and in oxidative stress induced apoptosis . ^^^ In unstimulated neonatal cardiac myocytes , Bcl 2 and Bcl xL were associated with the mitochondria , but Bad and Bax were predominantly present in a crude cytosolic fraction . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The differences of expression of BCL 2 , BCL 10 , BAX , and MCL 1 proteins of paired first resection and recurrence glioblastoma specimens were examined . ^^^ RESULTS : In the whole group , we found a significant up regulation of antiapoptotic BCL 2 ( median cumulative score of 15 in the primary , 19 at recurrence ; p < 0 . 0001 in the Wilcoxon test ) , BCLX ( median scores 20 and 25 , respectively , p < 0 . 0001 ) , and MCL 1 ( median scores 11 and 14 , p=0 . 0395 ) , and a significant down regulation of proapoptotic BAX ( median scores 14 and 11 , p < 0 . 0001 ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The expression of Bcl 2 , Bax , and Bcl 10 was not changed among Jurkat , Tax ( ) JPX 9 , and Tax ( + ) JPX 9 cells in the presence or absence of NF kappaB inhibitors . 10 chromosome linked inhibitor of apoptosis ( XIAP ) protein expression in Tax ( ) JPX 9 cells was significantly suppressed by NF kappaB inhibitors , however , its expression in Tax ( + ) JPX 9 cells was maintained even by the addition of NF kappaB inhibitors . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In the yeast two hybrid system , Mcl 1 binds to the hypophosphorylated mutant of BAD and interacts preferentially with different proapoptotic ( Bax , Bak , Bok , Bik , and BOD ) compared with antiapoptotic Bcl 2 family members ( Bcl 2 , Bcl xL , Bcl w , Bfl 1 , CED 9 , and BHRF 1 ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Western blot analysis demonstrated that neither p 53 nor Bcl 2 , Bcl XL and Bax protein expression changed during anoikis . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In asymptomatic transgenic mSOD 1 mice , expression of Bcl 2 , Bcl XL , Bad , and Bax does not differ from that in nontransgenic mice . ^^^ In contrast , in symptomatic mice , expression of Bcl 2 and Bcl XL , which inhibit apoptosis , is reduced , whereas expression of Bad and Bax , which stimulate apoptosis , is increased . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The mechanism by which FDC spare malignant B cells from apoptosis did not involve alterations in levels of Bcl 2 , Bcl XL , or Bax . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Apoptosis and expression of apoptosis regulating proteins bcl 2 , mcl 1 , bcl 10 , and bax in malignant mesothelioma . ^^^ We investigated apoptosis and the expression of bcl 2 , mcl 1 , bcl 10 , and bax in histological sections from 35 malignant mesotheliomas and 21 metastatic adenocarcinomas . ^^^ Moreover , the expression of bcl 2 , mcl 1 , bcl 10 , and bax were assessed by Western blotting in nonmalignant human mesothelial cells ( Met5A ) and seven malignant cell lines . ^^^ Patients with mesotheliomas showing a high apoptotic index ( > or =0 . 75 % ) had a worse prognosis ( P = 0 . 008 ) . bcl 2 positivity was observed in only seven cases , but bcl 10 , mcl 1 , and bax positivity was seen in all of them . ^^^ In immunoblotting experiments , all mesothelioma cell lines were negative for bcl 2 but positive for bcl 10 , mcl 1 , and bax . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
These pre apoptotic events were associated with the cleavage of the caspase 3 , while the expression of Bcl 2 , Bcl XL and Bax proteins was not affected by the presence of Tat . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In addition , bcl 10 ( s ) does not possess the 5th and 6th alpha helices ( thought to be the membrane spanning domains in bcl 2 , bcl 10 ( L ) , and bax ) and , therefore , should not be able to form membrane channels , thus eliminating this possible mechanism of action . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The aim of this study was to determine the role of Bcl 2 , Bcl 10 L , Bax , and c Fos in regulation of apoptosis , induced by ultraviolet light A ( UV A ) and daunorubicin ( DNR ) , in retinal pigment epithelium ( RPE ) cells grown on bovine extracellular matrix ( ECM ) coated or uncoated plastic dishes . ^^^ Cellular expression of Bcl 2 , Bcl 10 L , Bax , and c Fos was determined by the use of antibodies and flow cytometry , Western blot analysis , and immunocytochemical staining . ^^^ After UV A or DNR treatment , Bcl 2 , Bcl 10 L , Bax , and c Fos levels were differently regulated in cells grown on ECM coated dishes compared to cells grown on uncoated dishes . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Epigenetic determinants of resistance to etoposide regulation of Bcl 10 ( L ) and Bax by tumor microenvironmental factors . ^^^ We investigated how survival signals in the cellular microenvironment affect the expression , protein conformation , and protein protein interactions of the Bcl 2 family proteins Bax and Bcl 10 ( L ) and how changes in response to microenvironmental signals alter the response of cancer cells to the drug etoposide . ^^^ Bcl 10 ( L ) gene transcription and protein levels of Bcl 10 ( L ) and Bax were measured by northern and western blotting , respectively . ^^^ Bax conformation and Bax Bcl 10 ( L ) interactions were monitored by immunofluorescence and immunoprecipitation , respectively . ^^^ VCAM 1 and interleukin 4 mediated signals diminished conformational changes in Bax protein and prevented the etoposide induced disruption of constitutive Bax Bcl 10 ( L ) binding . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Here , using yeast two hybrid and co immunoprecipitation studies , we show that RAD 9 , a human protein involved in the control of a cell cycle checkpoint , interacts with the anti apoptotic Bcl 2 family proteins BCL 2 and BCL 10 L , but not with the pro apoptotic BAX and BAD . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Furthermore , an additional 18 kDa Bax related protein was expressed by the stimulation of G CSF or IL 6 , while Bcl 2 and Bcl 10 proteins remained unchanged . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Immunohistochemistry and RT PCR showed that 71 % of the cell lines were Bcl 2 positive , 62 % were Bax positive , 38 % were Bcl XL positive and 62 % were Bcl XS positive . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Adenovirus mediated transfer of Bcl 10 ( L ) protects neuronal cells from Bax induced apoptosis . ^^^ Two molecules belonging to the Bcl 2 family , Bcl 2 and Bcl 10 ( L ) , protect cells from Bax induced apoptosis and show distinct expression patterns in adult neurons , with downregulated Bcl 2 and highly upregulated Bcl 10 ( L ) expression . ^^^ To investigate the biological functions of these two molecules in Bax mediated apoptosis in neurons , we transduced various levels of Bcl 10 ( L ) or Bcl 2 via adenoviral vectors into nerve growth factor ( NGF ) treated PC 12 cells . ^^^ Bcl 10 ( L ) expressed at a wide range of levels conferred a high level of protection against Bax mediated apoptosis . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Then we determined whether Bcl 2 , Bax , Bcl xL and Bcl xS , which regulate the release of cytochrome c from mitochondria , were altered in the ischemia tolerant CA 1 region . ^^^ Bcl 2 and Bax were up regulated in the ischemia tolerant group , but Bcl xL and Bcl xS showed no apparent difference in their expression . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
At the same time , neither overexpression of Bcl xL in A 2780 , nor its antisense expression in A 2780 ( 100 ) , and nor overexpression of Bax in A 2780 ( 100 ) , significantly affected drug sensitivity of either line . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Significantly , As ( 2 ) O ( 3 ) induced apoptosis of HL 60 / Bcr Abl and K 562 cells was associated with a decline in Bcr Abl protein levels , without any significant alterations in the levels of Bcl 10 ( L ) , Bax , Apaf 1 , Fas , and FasL . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Inhibition of endogenous p 53 activity did not affect the sensitivity of TAD 2 cells to iodide , and Western blot analysis demonstrated that p 53 , Bcl 2 , Bcl XL , and Bax protein expression did not change when cells were treated with iodide . ^^^ This type of apoptosis is p 53 independent , does not require protein synthesis , and is not induced by modulation of Bcl 2 , Bcl XL , or Bax protein expression . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The apoptosis resistant phenotype of A 11 cells was associated with the expression level of caspase 3 , but not with those of Bcl 2 , Bcl 10 ( L ) Bax , p27Kip1 and DAP kinase . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Influence of age on hypoxia / reoxygenation induced DNA fragmentation and bcl 2 , bcl xl , bax and fas in the rat heart and brain . ^^^ The ratios of bcl 2 / bax and of bcl xL / bax were higher in the old heart and brain compared to that in the young adult after hypoxia / reoxygenation . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
This study hypothesized that apoptosis regulatory genes other than Fas Fas ligand , such as p 53 , p 21 ( Waf1 / Cip1 ) , bcl 2 , bcl 10 , and bax , may also participate in epithelial cell apoptosis in this model . ^^^ The expression of bcl 10 ( L ) and bax mRNA was strongly up regulated at 1 h to 7 days . ^^^ The expression of bcl 10 protein was up regulated in lymphocytes and macrophages , whereas bax protein was up regulated in both epithelial and inflammatory cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
PhIP induced rat mammary gland carcinomas were examined for mutations in several genes ( exons ) known to regulate cell growth and apoptosis , including p 53 ( 4 8 ) , p 21 ( Waf 1 ) ( coding region ) , Apc ( 14 , 15 ) , B catenin ( 3 ) , E cadherin ( 9 , 13 , 15 ) , Bcl 10 ( coding region ) , Bax ( 3 ) , IGFIIR ( 28 ) , and TGFBIIR ( 3 ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Role of Bcl 2 family proteins ( Bax , Bcl 2 and Bcl 10 ) on cellular susceptibility to radiation in pancreatic cancer cells . ^^^ The aim of this study was to examine Bax , Bcl 2 and Bcl XL proteins in human pancreatic cancer cell lines and to clarify the mechanism of radiation resistance . ^^^ Both PANC 1 / Rad and AsPC 1 / Rad cells had greater Bcl XL expression than the parental cells , and the basal level of the Bax / Bcl 2 ratio was no longer predictive of radiosensitivity . ^^^ Upregulated expression of Bax protein after irradiation was not related to induction of apoptosis in these cells , suggesting that overexpression of Bcl XL and functional reconstruction of Bcl 2 family proteins are important factors in acquired radioresistance . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In this model , TAM resistance resulted in an increase in the detectable basal levels of cyclin E , GADD 153 , p 16 , BAX , Bcl XL , and wild type and mutant p 53 , an increase in TAM induction of p 16 , and a decrease in the detectable basal levels of cyclin D 1 , p 21 and p 27 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The putative pore forming domain of Bax regulates mitochondrial localization and interaction with Bcl 10 ( L ) . ^^^ The enhanced function of this Bax mutant was correlated with increased binding to Bcl 10 ( L ) , through a BH 3 independent mechanism . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bcl 2 : bax and bcl 2 : Bcl 10 ratios by image cytometric quantitation of immunohistochemical expression in ovarian carcinoma : correlation with prognosis . ^^^ Bax and bcl 10 are members of the bcl 2 family ; when overexpressed , they can counteract the ability of bcl 2 to inhibit apoptosis . ^^^ This suggests a model in which the ratios of bcl 2 to bax and bcl 10 can be used to determine response to therapy and prognosis . ^^^ The expression of bcl 2 , bax and bcl 10 was studied in 50 ovarian carcinomas . ^^^ The ratios were obtained by dividing the PPA of bcl 2 by the PPA of bax and bcl 10 . 17 of 50 ovarian carcinomas ( 34 % ) stained positively for bcl 2 , 39 for bax ( 78 % ) and 47 for bcl 10 ( 94 % ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Similarly , decreased Bax expression during STS treatment , coupled with overexpression of the antiapoptotic Bcl 10 ( L ) and inability to translocate cytochrome c to the cytosol , provided a mechanism for the insensitivity of PC 3 cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We examined immunohistochemically 4 apoptosis regulating bcl 2 familial proteins ( bcl 2 , mcl 1 , bcl 10 , and bax ) in the biliary epithelium in 19 cases of primary biliary cirrhosis . ^^^ Bcl 2 and mcl 1 are inhibitors of apoptosis , bcl 10 , probably bcl XL in biliary epithelial cells , an inhibitor , and bax , a promoter of apoptosis . ^^^ Mcl 1 , bcl 10 , and bax were diffusely detectable at the any level of the intrahepatic biliary tree , with a staining pattern that was diffuse and cytoplasmic . ^^^ Expression levels of mcl 1 , bcl 10 , and bax were similarly reduced to that of bcl 2 in these 2 diseases . ^^^ These findings suggest that bax is not important as a proapoptotic factor in the damaged bile ducts and that downregulation of bcl 2 and mcl 1 , and probably that of bcl XL , leads to a decrease in the threshold of apoptosis and increase in the vulnerability to apoptotic stimuli in these bile ducts , followed by the progressive apoptotic loss of interlobular bile ducts , in primary biliary cirrhosis . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In the multimodally treated esophageal cancer patients , strong expression of p21WAF1 and accumulation of p 53 were predictors of poor survival , whereas expression of Bcl 2 , Bax , and Bcl XL had no prognostic significance . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In an effort to understand this role , we have used polyomavirus transformed pyF 111 rat fibroblasts , which are hypersusceptible to apoptosis as they constitutively hyperexpress PKC delta , but can not make the antiapoptotic Bcl 2 and Bcl 10 ( L ) proteins , while making the proapoptotic Bax protein . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Results from Western blot analysis indicated that HepG 2 cells did not express either the death repressor Bcl 2 , or the death promoters Bcl XS and Bax . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Overexpression of BCL 2 , BCL 10 , and BAX in primary central nervous system lymphomas that occur in immunosuppressed patients . ^^^ The BCL 2 family proteins ( BCL 2 , BCL 10 , MCL 1 , and BAX ) and p 53 expression were studied by immunohistochemistry on paraffin slides . ^^^ In contrast , PCNSLs in immunosuppressed patients were shown to express high levels of BCL 2 , BCL 10 , and BAX in more than 80 % of tumor cells in 7 , 10 , and 11 cases , respectively . ^^^ In immunocompetent patients , only one case showed a high level of BCL 2 expression in more than 80 % of the cells , whereas BCL 10 and BAX were overexpressed in two cases . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
As expected , gamma irradiation increased p 53 protein and bax mRNA levels and the presence of hGM CSF dramatically modulated bax / bcl 10 ( L ) ratio . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
This study analyzes the temporal and spatial relationship between expression of pro and anti apoptotic members of the Bcl 2 gene family ( Bcl 2 , Bcl 10 ( L ) , Bax ) and epidermal growth factor ( EGF ) , insulin like growth factor ( IGF 1 ) , and transforming growth factor beta ( TGF beta ) , growth factors that are thought to be reparative in ARF . ^^^ In control kidneys , expression of Bcl 2 , Bcl 10 ( L ) was low in epithelium of distal tubules , Bax had low to moderate expression in the proximal tubule and had low expression in the distal tubule , EGF and IGF 1 had low to moderate expression in the distal tubule , and TGF beta had low expression in the proximal tubule . ^^^ In contrast , within 24 h of reperfusion , distal tubules showed a marked increase in expression of Bcl 2 and a moderate increase in Bcl 10 ( L ) and Bax . ^^^ Proximal tubules showed a marked increase in Bax expression and a moderate increase in Bcl 10 ( L ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bcl 2 , Bax , Bcl 10 ( L ) and Bcl 10 ( S ) expression in neoplastic and normal endometrium . ^^^ The two anti apoptotic proteins Bcl 2 and Bcl 10 ( L ) , and the two pro apoptotic proteins Bax and Bcl 10 ( S ) were measured by Western blotting in 51 neoplastic and 8 normal endometrial samples . ^^^ Despite the fact that the amounts of Bcl 2 , Bax and Bcl 10 ( L ) proteins in the neoplastic population were not significantly differently distributed according to the clinicopathological features of the patients , the differences observed between normal and neoplastic samples suggest that these proteins may play a role in endometrial carcinoma : long term follow up studies will be required to confirm this hypothesis . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Among multimodally treated esophageal cancer patients , again strong expression of p21WAF1 as well as accumulation of p 53 were predictors of poor survival , whereas expression of Bcl 2 , Bax and Bcl XL did not show any prognostic influence . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bcl 2 family proteins govern this mitochondria dependent apoptosis pathway , with proteins such as Bax functioning as inducers and proteins such as Bcl 2 and Bcl 10 ( L ) serving as suppressors of cell death . ^^^ The BAR protein contains a SAM domain , which is required for its interactions with Bcl 2 and Bcl 10 ( L ) and for suppression of Bax induced cell death in both mammalian cells and yeast . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Apoptosis could be induced in cell lines that overexpressed Bcl 2 or Bcl XL when the cells were treated with anti Fas antibody , tumor necrosis factor alpha , staurosporine , or Bax , in addition to TC A . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Overexpression of anti apoptotic members of the Bcl 2 family such as Bcl 2 and Bcl 10 ( L ) has been implicated in cancer chemoresistance , whereas high levels of pro apoptotic proteins such as Bax promote apoptosis and sensitize tumor cells to various anticancer therapies . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Four hours after AMPH injection , increase in c myc and decreases in Bcl 2 and Bcl 10 ( L ) mRNAs occurred in all tissues , whereas p 53 , Bax , and Bcl 10 ( S ) mRNAs increased in N 30 and HCC . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Furthermore , BH 4 oligopeptides of Bcl 2 and Bcl 10 ( L ) , but not mutant peptides , were able to inhibit both VDAC activity on liposomes even in the presence of Bax and apoptotic Deltapsi loss in isolated mitochondria . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In this report , we show that the opposing actions of MR and GR on neuronal survival result from their ability to differentially influence the expression of members of the bcl 2 gene family ; specifically , in the rat hippocampus , activation of GR induces cell death by increasing the ratio of the proapoptotic molecule Bax relative to the antiapoptotic molecules Bcl 2 or Bcl 10 ( L ) ; the opposite effect is observed after stimulation of MR . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Hepatotoxicant treated WT and TNFR DKO mice induced liver transcripts for the pro and anti apoptotic genes , Bax and Bcl 10 ( L ) , respectively , indicating TNF independent gene activation . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
An immunohistochemical study showed that the lymphoma cells were positive for leukocyte common antigen , Epstein Barr virus , bax . and bcl XL , and negative for L 26 and bcl 2 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bcl 2 , bcl 10 , and bax expression in dysembryoplastic neuroepithelial tumors . ^^^ BACKGROUND : Bcl 2 , bcl 10 and bax are regulatory proteins which are variably expressed in brain tissue and are known to be involved in the regulation of apoptosis ; bcl 2 and bcl 10 inhibit apoptosis and bax generally promotes apoptosis . ^^^ The oligodendroglial like cells of DNT stained positively for bcl 2 in 2 / 17 tumors , bcl 10 in 10 / 17 tumors , and bax in 12 / 17 tumors . ^^^ The neuronal cell component of the DNT stained positively with bcl 2 in 15 / 17 tumors , bcl 10 in 5 / 17 tumors , and bax in 8 / 17 tumors . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Furthermore , lutein and ATRA selectively increased the ratio of Bcl xL : Bax protein expression in normal cells but not transformed mammary cells , suggesting a possible mechanism for selective modulation of apoptosis . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The expression patterns of the calcium binding proteins calbindin and parvalbumin and of the apoptosis modulating proteins Bcl 2 , Bax , and Bcl 10 were studied in the cerebellum of patients with multiple system atrophy ( MSA ) . ^^^ Calbindin and parvalbumin immunoreactivity was markedly decreased in MSA Purkinje cells whereas Bax and Bcl 10 protein expression was increased . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We demonstrated in the yeast two hybrid system that BFL 1 interacts strongly with human BAX but is not able to form homodimers nor to interact with human BCL 2 or BCL xL . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Late apoptotic AxV ( hi ) cells did not express Bcl 10 ( S ) or Bax . ^^^ RESULTS : ( 1 ) AxV staining is more sensitive than sub G 1 or ISEL in detecting early apoptotic cells ; ( 2 ) only late apoptotic cells are equally detected by all assays ; ( 3 ) AxV is a valuable tool in the detection and isolation of apoptotic cells at different stages of PCD ; and ( 4 ) pro apoptotic Bcl 10 ( S ) and Bax are expressed at early , not late , stages of apoptosis . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Biochemical and genetic analysis of the mitochondrial response of yeast to BAX and BCL 10 ( L ) . ^^^ The BCL 2 family includes both proapoptotic ( e . g . , BAX and BAK ) and antiapoptotic ( e . g . , BCL 2 and BCL 10 ( L ) ) molecules . ^^^ We examined the function of BAX and BCL 10 ( L ) using genetic and biochemical approaches in budding yeast because studies with yeast suggest that BCL 2 family members act upon highly conserved mitochondrial components . ^^^ Coexpression of BCL 10 ( L ) prevented all BAX mediated responses . ^^^ We also assessed the function of BCL 10 ( L ) and BAX in the same strain of Saccharomyces cerevisiae with deletions of selected mitochondrial proteins that have been implicated in the function of BCL 2 family members . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We observed baseline expression of the anti apoptotic Mcl 1 and pro apoptotic Bax proteins in immunoblots of eosinophil lysates , but not Bcl 10 , Bcl 2 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In this study , using MRP overexpressing multidrug resistant nasopharyngeal cancer cells , we examined the expression of apoptosis related genes including p 53 , p21WAF1 , bax and bcl Xs between drug sensitive KB and its resistant KB / 7D cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In contrast to previous studies , we found no evidence of Bad binding to anti apoptotic Bcl 2 , Bcl XL or McI 1 , or of alterations in Bax heterodimers . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Apoptosis and regulation of Bax and Bcl 10 proteins during human neonatal vascular remodeling . ^^^ The expressions of Bax and Bcl 10 were stronger in umbilical artery than in the neonatal aorta , but Bcl 2 was weak in both arteries in immunohistochemistry . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We have recently shown that some of these proteins , such as Bcl 10 ( L ) , Bax , and Bak , directly modulate the mitochondrial voltage dependent anion channel ( VDAC ) and thus regulate apoptogenic cytochrome c release and potential loss . ^^^ Anti apoptotic Bcl 10 ( L ) and its BH 4 oligopeptide completely closed the VDAC , in contrast to the Bax . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In human cells , Bax sigma function was counteracted by Bcl xL overexpression , and co immunoprecipitation experiments indicated that Bax sigma was associated with Bcl xL . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
PC 12 cells express endogenous Bcl xS , Bax and Bcl xL proteins . ^^^ Subcellular fractionation revealed that Bax is presented mainly in the cytosolic and the heavy membrane fractions , Bcl xS is present only in the cytosol , and the anti apoptotic protein Bcl xL is located mainly in the heavy membrane fraction . ^^^ The Bax induced cell death was inhibited by co expression of Bax with Bcl 2 or Bcl xL , but was not inhibited by Z VAD FMK , NGF , or the Bcl 2 ml 3 or deltaC 22 mutants . ^^^ Bcl xS and Bax induce different apoptotic pathways in PC 12 cells . ^^^ Apoptosis is regulated by the action of the Bcl 2 family of proteins , which includes anti and pro apoptotic members such as Bcl xS and Bax . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In contrast , the expression of Bcl 10 ( L ) decreased and that of proapoptotic Bax , Bad , and Bak was unchanged or down regulated after removal of growth factors . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
To investigate the molecular pathway to apoptosis induction , members of the Bcl 2 family of proteins were examined ( Bcl 2 , Bcl 10 , Bax , and Bak ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We examined apoptosis and expression of p 53 , E2F 1 , bax , bclx ( L ) and bc 12 proteins in two L5178Y ( LY ) murine lymphoma sublines , LY R and LY S , which differ in radiosensitivity and double strand break ( DSB ) repair . ^^^ We found that there is no change in expression of E2F 1 , bax , bclx ( L ) or bc 12 proteins in both LY sublines after 10 irradiation . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We first analyzed mRNA expression of pro apoptotic Bak and Bax along with that of anti apoptotic Bcl 2 and Bcl xL , using breast cancer specimens of 27 patients . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The described effects of TGF beta 1 neutralization were observed in the absence of any relevant effect on cell cycle ; number of cell divisions ; p 53 , c myc , and p 21 RNA levels ; bcl xL and bax protein levels ; and c myc / p16 / p21 / p107 / Rb cell cycle related protein levels . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In addition , immunohistochemistry was performed for an array of apoptosis related proteins , i . e . the recently described apoptosis specific protein cJun / AP1 ( ASP ) , the proto oncogenes c Jun , c Jun AP 1 , Bcl 2 , Bax , Bcl 10 , p 53 , CD 95 ( Fas / Apo 1 ) , activated caspase 3 , several heat shock proteins ( alpha B crystallin , ubiquitin ) , and alpha synuclein . ^^^ There were no significant differences in the expression of c Jun , ASP , Bcl 2 , Bax , and Bcl 10 in substantia nigra neurons between PD , DLB , and controls nor between cortical and subcortical neurons with and without Lewy bodies . ^^^ No expression of p 53 , and activated caspase 3 , or any of the examined stress proteins was seen in neurons , while reactive astroglia and microglia were decorated by antibodies to Bcl 2 , Bax , alpha B crystallin and less , to Bcl 10 and caspase 3 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The neoplastic B cells showed similar phenotypes and genotypes in most cases ( CD20+ , CD79+ , CD 5 , CD 10 , cyclin D 1 , bcl 2+ , bcl 10 , bax , t ( 14 ; 18 ) negative ) . p 53 protein was expressed in five cases , and four harboured mis sense or loss of function mutations in the p 53 gene . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Using reverse transcriptase polymerase chain reaction , cloning , and sequencing techniques , we have found that HL 60 cells express bak , bik , bax , bad , bcl 2 , bcl xL , bcl w , bfl 1 , fas , and caspases 1 4 and 7 10 . ^^^ Peripheral blood neutrophils expressed bak , bad , bcl w , bfl 1 , fas , and caspases 1 , 3 , 4 , and 7 10 , but hardly expressed bcl 2 , bcl xL , bik , bax , and caspase 2 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bcl 2 , bax , bcl 10 ( L ) and bcl 10 ( S ) expression in neoplastic and normal cervical tissue . ^^^ We simultaneously assessed bcl 2 , bax , bcl 10 ( L ) and bcl 10 ( S ) expression levels by Western blotting on 53 primary untreated cervical cancers and 15 normal samples . ^^^ Bcl 2 showed a trend to be lower in neoplastic than in normal samples ( P < 0 . 01 ) , while no significant difference was observed for bax and bcl 10 ( L ) . ^^^ Bcl 2 , bax and bcl 10 ( L ) levels in responding and non responding patients were not differently distributed . ^^^ Bcl 2 , bax and bcl 10 ( L ) are likely to play a role in the natural history of cervical tumors , but their clinical significance in predicting response to treatment and clinical outcome needs long term follow up studies . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The family can be divided into two classes : those such as Bcl 2 and Bcl xL that suppress cell death , and others , such as Bak and Bax , that appear to promote apoptosis . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
This is opened by pro apoptotic members of the Bcl 2 family such as BAX and prevented by anti apoptotic members such as Bcl 10 ( L ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Immunoblots showed no downregulation of Bcl 2 or Bcl xL and no upregulation of Bax , whereas decreased mitochondrial membrane potential was readily measurable 24 h after cytokine deprivation . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The earliest event induced by drug exposure was increase in Bad protein levels , followed by Bcl 2 down regulation , cytochrome c release , and Bcl xL and Bax up regulation . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We used single cell techniques ( patch clamp , videomicroscopy and immunocytochemistry ) to clarify some of the specific aspects of S 100 induced apoptosis , the modality ( ies ) of early intracellular Ca2+ concentration increase and the expression of some classes of genes ( c fos , c jun , bax , bcl 10 , p 15 , p 21 ) known to be implicated in apoptosis of different cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
CONCLUSIONS : These data demonstrate , at the molecular level , that bcl XL is selected as an apoptosis protective gene in place of bcl 2 while bax retains its dominant proapototic role . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The downregulation of Bcl 10 ( L ) protein occurred from 6 h , while Bax protein conversely showed a slight increase from 6 h . ^^^ Taken together , the present findings show that the dose dependent apoptotic effect of etoposide is based on a change in the balance between Bcl 10 ( L ) and Bax , which precedes the activation of caspase 3 . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We have studied by immunocytochemistry , Western blotting and RT PCR the expression pattern of Bcl xL , Bcl 2 and BAX in the in vitro model of neuronal differentiation constituted by retinoic acid ( RA ) treated NTera 2 / D1 ( NT2 / D1 ) cells . ^^^ Whereas BAX level did not change significantly during the RA treatment , Bcl xL level increased markedly during the first week , before returning to basal level during the second week . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Using immunohistochemical techniques and Western blot analysis , the possible role of Bcl 2 family members Bax , Bcl 2 , Bcl 10 ( s ) , and Bcl 10 ( l ) in male germ cell density related apoptosis and DNA damage induced apoptosis was studied . ^^^ Furthermore , as Bcl 10 ( l ) , but not Bcl 2 , is present in spermatogonia and spermatocytes , Bcl 10 ( l ) may regulate germ cell density , possibly in cooperation with Bax . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
To determine the role of bcl 2 , bcl 10 and bax in melanocytic tumors we investigated the differential expression of these genes via RT PCR in tissue samples from human benign nevi , primary melanomas and melanoma metastases in comparison with normal skin . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
When p 53 , c Myc , Bcl 2 , Bcl 10 ( L ) , and Bax were measured by flow cytometry and the activities of caspase 1 and caspase 3 like protease determined with Ac YVAD AMC or Ac DEVD AMC as substrates , the profile of ROS induced changes in these apoptosis regulatory and effector proteins suggests that elevation of c Myc , p 53 , and Bax and activation of caspase 3 play an important role in the apoptosis . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Furthermore , exposure of PCP treated cultures to NMDA led to increased expression of Bax and decreased expression of Bcl 10 ( L ) . ^^^ The Bcl 10 ( L ) / Bax ratio was markedly decreased by 30 microM NMDA in the PCP treated , but not control , cultures . ^^^ Addition of superoxide dismutase and catalase prevented the decrease in Bcl 10 ( L ) / Bax . ^^^ This study suggests that NMDA induced changes in Bax and / or Bcl 10 ( L ) involve the formation of reactive oxygen species . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Downregulation of proapoptotic proteins Bax and Bcl 10 ( S ) in p 53 overexpressing hepatocellular carcinomas . ^^^ In addition , we observed significant underexpression of two proapoptotic proteins , Bax and Bcl 10 ( S ) , in 81 % ( P = 0 . 02 ) and 64 % ( P = 0 . 03 ) of HCC , respectively . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We have examined , in a rat glioma cell line A15A5 , the effect of the stable transfection of human bcl 2 , bax and bcl xl on MMPs expression . ^^^ In bcl 2 and bcl xl transfected cells , the transcription of MMP 9 was decreased compared to that of control or bax transfected cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Western blot analysis of Bcl 2 , Bcl xL and Bax expression and immunofluorescence analysis of promyelocytic leukemia ( PML ) protein indicated that apoptosis induced by spicamycin and KRN 5500 was associated with down regulation of Bcl 2 expression and modulation of PML protein . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Mitochondrial function , that is , incorporation of 3 , 3 ' dihexyloxacarbocyanine iodide [ DiOC ( 6 ) ( 3 ) ] and generation of reactive oxygen species ( ROS ) as well as expression of c Myc and Bcl 2 family members ( Bcl 2 , Bcl 10 ( L ) , Bax ) were evaluated by multiparameter flow cytometry . ^^^ Moreover , Bax protein was overexpressed in postG ( median fluorescence intensity = 180 , range 168 186 ) compared with preG cultures ( median fluorescence intensity = 75 , range 68 80 ; p < 0 . 01 ) , while no differences in Bcl 2 , Bcl 10 ( L ) , and c Myc staining intensity were observed . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bcl 10 and Bax regulate mouse primordial germ cell survival and apoptosis during embryogenesis . ^^^ Primordial germ cells ( PGCs ) in bcl 10 hypomorph mice migrated to the genital ridge by E12 . 5 but were depleted by E15 . 5 , a time when Bcl 10 and Bax were present . ^^^ Bax was detected by immunohistochemistry in germ cells from bcl 10 hypomorph and control testes at E12 . 5 and E13 . 5 . ^^^ Alternatively , the loss of Bcl 10 function in the hypomorph was corrected by the deletion of both copies of the bax gene , resulting in a restoration of germ cell survival . ^^^ These findings demonstrate that the balance of Bcl 10 and Bax control PGC survival and apoptosis . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
METHODS : Using Western blotting and immunohistochemistry , the authors investigated the expression of bcl 2 , bcl xL , bax , caspase 1 , and caspase 3 in temporal cortex samples from patients who had undergone temporal lobectomy surgery for intractable epilepsy ( n = 19 ) . ^^^ Bcl 2 , bax , and caspase 3 immunoreactivity was increased predominantly in cells with the morphologic appearance of neurons , whereas bcl xL immunoreactivity was increased in cells with the appearance of glia . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The degree of apoptosis was analyzed in relation to several clinicopathologic parameters , cell proliferative activity , and immunohistochemical expression of apoptosis related proteins , including bcl 2 , bax , bcl 10 , bak , p 53 , p 21 ( WAF1 / CIP1 ) , Fas , and Fas ligand . ^^^ Many synovial sarcomas were diffusely positive for bcl 2 family proteins ( bcl 2 , bax , bcl 10 , and bak ) and were negative or only sporadically positive for Fas , Fas ligand , p 53 , and p 21 ( WAF1 / CIP1 ) proteins . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Similarly , levels of the antiapoptotic protein Bcl 10 ( L ) are significantly decreased ( P < . 05 ) compared with controls at t = 0 resulting in an increased ( approximately 3 . 5 fold ) Bax / Bcl 10 protein ratio that is significantly elevated ( P < . 05 ) compared with controls . ^^^ These observations combine to suggest that retrorsine injured hepatocytes are removed after PH via apoptotic pathways dependent on relative levels and localization of Bax and Bcl 10 ( L ) protein . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
These results indicate that Bax promotes apoptosis regardless of ceramide formation and that Bcl 2 or Bcl xL prevents ceramide formation by repressing neutral sphingomyelinase as well as ceramide induced cytochrome c release . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In Epo and SCF stimulated cells , we found a marked increase in the level of Bcl 10 ( L ) protein expression and downregulation of Bax expression , apparent from day 4 and more pronounced on days 8 and 21 . ^^^ In contrast , Bcl 10 ( L ) protein expression was downregulated in G CSF and SCF stimulated cells compared with cells cultured in medium alone , whereas there was no sign of change in the level of Bax . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Transgenic animal models and expression studies have shown that caspases , Bcl 2 , Bax , and possibly Bcl 10 are necessary players for the control of programmed cellular death in retinal ganglion cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
To explore the potential involvement of Bcl 2 family members in this process , the expression and localization of some Bcl 2 family proteins ( Bcl 2 , Bcl xL , Bcl w , Bak , Bax , and Bad ) and p 53 were analyzed during testicular development in the rat by Western blotting and immunohistochemistry . ^^^ The dynamic changes in the expression profiles of Bcl 2 family proteins are consistent with a model in which germ cells are primed for apoptosis during the first cycle of spermatogenesis by de novo expression of the death effectors Bax and Bad in a p 53 dependent manner and these proteins are prevented from triggering further apoptosis after the first spermatogenic cycle has been set up by anti apoptotic Bcl 2 family proteins Bcl xL and Bcl w . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Analysis of bcl 2 family gene transfectants revealed a down regulation of TNF induced apoptosis by bcl 2 and bclX overexpression , and an up regulation by bax gene . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The expression of Bcl 2 , Bcl 10 ( L ) , and Bax was evaluated in both cell types by Western blot analysis . ^^^ C 6 glioma cells strongly expressed Bcl 10 ( L ) and only weakly expressed Bcl 2 and Bax , whereas SY5Y neuroblastoma cells expressed lower levels of Bcl 10 ( L ) and higher levels of both Bcl 2 and Bax . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The apoptosis cascade was due to up regulation of Bax protein , down regulation of Bcl XL protein , and activation of caspase 3 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The present study examined the expression of some Bcl 2 family members , including Bcl 2 , Bcl 10 ( L ) , Mcl 1 , and Bax , in response to cytokine stimulation in TF 1 and JYTF 1 cells in which SCF costimulation is differentially required for optimal proliferation . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
An increase in the antiapoptotic Bcl 2 and Bcl xL protein levels and a decrease in the proapoptotic Bax and Bcl xS protein levels were also detected by Western blot analysis after SNAP treatment . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Expression of Bcl 10 ( L ) and Bid decreased significantly in the cadmium treated cells , although no apparent change in Bcl 2 and Bax expression was found . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Deparaffinized tissue sections from 22 OLP and 10 control oral biopsy specimens were immunohistochemically stained with anti Bcl 2 , anti Bcl 10 , anti Bax and anti TNF alpha antibodies . ^^^ All control tissues were TNF alpha negative , thus indicating a possible involvement of this cytokine in the pathogenesis of OLP The differences in the staining intensities of Bcl 10 and Bax between OLP and normal epithelium were slight ; therefore an obvious association of the phenotypic TNF alpha expression with these apoptosis regulating proteins was not apparent . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
RESULTS : Herein , we showed that inhibition of ERK1 / 2 activities caused ( 1 ) a G 1 arrest ; ( 2 ) a down regulation of the expression levels of the anti apoptotic homologs Bcl 2 , Mcl 1 , and Bcl 10 ( L ) without affecting the pro apoptotic levels of Bax and Bak ; ( 3 ) a promotion of caspases 3 , 6 , 8 , and 9 activities ; ( 4 ) a stimulation of PARP cleavage ; and ( 5 ) a programmed cell death by apoptosis . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
After exposure to CDDP , p 53 and Bax protein expression increased and Bcl xL expression decreased in the KF cells and TP 53 gene transducted SK OV 3 cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Importantly , the early release of cytochrome c from mitochondria closely correlates with the degradation of Bcl 2 and Bcl xL and a decrease in the ratios of Bcl 2 and Bcl xL to Bax during STA . ^^^ These findings suggest that the degradation of Bcl 2 and Bcl xL may favor Bax to induce cytochrome c release from mitochondria , which subsequently activates downstream caspases in STA . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In studies of apoptosis associated proteins , BMP 2 was seen to down regulate the expression of Bcl 10 ( L ) ; however , BMP 2 had no effects on the expression of Bcl 2 , Bax , or Bad . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
CGP57148B treatment down regulated antiapoptotic XIAP , cIAP 1 , and Bcl 10 ( L ) , without affecting Bcl 2 , Bax , Apaf 1 , Fas ( CD 95 ) , Fas ligand , Abl , and Bcr Abl levels . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bax and Bcl xL independently regulate apoptotic changes of yeast mitochondria that require VDAC but not adenine nucleotide translocator . ^^^ We have previously shown that Bax and Bak open the voltage dependent anion channel ( VDAC ) allowing cytochrome c to pass through the channel , and Bcl xL closes the channel . ^^^ However , it has been reported that it is adenine nucleotide translocator ( ANT ) with which Bax / Bcl xL interacts that modulate the channel activity . ^^^ The data also indicate that Bcl xL and Bax possess an ability to regulate mitochondrial membrane permeability independently of other Bcl 2 family members . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The mitochondrial permeability transition ( PT ) pore , also called the mitochondrial megachannel , is a multiprotein complex formed at the contact site between the mitochondrial inner and outer membranes , exactly the same location at which Bax , Bcl 2 and Bcl XL are particularly abundant . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In FDCP Mix cells , neither IL 3 nor TGF beta 1 induced any change in Bcl 10 ( L ) protein levels or the proapoptotic proteins Bad or Bax . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In MCF 7 , an increase in Bad and Bax protein expression and a decrease in Bcl 10 ( L ) protein and Bcl 2 protein and mRNA were observed . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Hepatic mRNA levels for Fas , the apoptosis promoting gene Bax , and the anti apoptotic gene , Bcl 10 ( L ) , were up regulated following 4 and 7 DMN exposures in both WT and TNFR DKO mice as compared to vehicle controls . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
METHODS AND RESULTS : By counting apoptotic biliary cells and by immunostaining apoptosis related proteins in normal liver , fatty liver , and those with acute viral hepatitis , chronic viral hepatitis , and hepatitis virus related cirrhosis , it was found that the larger the intrahepatic bile ducts became , the more biliary epithelial cells underwent apoptosis . bcl 2 , an inhibitor of apoptosis , was diffusely expressed in the interlobular bile ducts , but rarely detectable in the large and septal bile ducts . bcl XL and mcl 1 , inhibitors of apoptosis , and bax , a promoter of apoptosis , were diffusely expressed along the intrahepatic biliary tree . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
During the leukemic phases , the clonal cells were activated blasts expressing elevated levels of wild type ( wt ) p 53 , Bcl 2 , Bcl 10 ( L ) , and Bax , while Bak expression increased during the decline of lymphocytosis . ^^^ Bax heterodimerized with Bcl 2 but not with Bcl 10 ( L ) . ^^^ The elevation in Bcl 2 , Bcl 10 ( L ) and Bax expression during early leukemic phases seems to result from cell activation since a similar increase was induced by activating the remission phase leukemic cells in culture . ^^^ The data suggest that wt p 53 , Bcl 10 ( L ) , and Bcl 2 / Bax heterodimers support the accumulation of activated leukemic cells during the leukemic phases , while Bax and Bak may be involved in their decline during regression . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bcl 10 ( l ) and Bax play important roles in the regulation of apoptosis . ^^^ This study investigated the involvement of the mitochondrial death pathway and the role of Bcl 10 ( l ) and Bax in the escape from apoptosis after prolonged serum deprivation in Madin Darby canine kidney ( MDCK ) cells . ^^^ Bax / Bcl 10 ( l ) coimmunoprecipitation by anti Bax antibody showed reduced Bax / Bcl 10 ( l ) interaction at the membrane at 72 h , but not at 24 or 48 h . ^^^ Amelioration of the leakage of cytochrome c and apoptosis requires not only the increase of Bcl 10 ( l ) / Bax ratio , but also the release of Bcl 10 ( l ) from Bax at the membrane . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In 56 specimens [ CCH , n=1 ; MTC with CCH , n=26 ; MTC , n=20 ; lymph node metastasis ( LNM ) , n=9 ] from 46 patients [ multiple endocrine neoplasia type 2a ( MEN2a ) , n=24 ; MEN2b , n=2 ; familiar MTC ( FMTC ) , n=4 ; sporadic MTC , n 16 ] and 3 cases of non neoplastic CCH , proliferation activity ( MIB 1 ) , the rate of apoptosis [ dUTP nick end labelling ( TUNEL ) ] and expression of p 53 , bcl 2 , bcl 10 and bax were investigated and compared with clinical data . ^^^ In MEN associated CCH and small MTC , bcl 2 was strongly expressed , bcl 10 was moderately expressed and bax was only weakly expressed . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In contrast , levels of Bax protein remained relatively unchanged in four of the cell lines , and levels of Bcl 10 ( L ) , Bcl 10 ( S ) , and Bak proteins showed little or no cell cycle dependent changes in Jurkat T cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Heterodimerization of Bcl 2 and Bcl 10 ( L ) with Bax and Bad in colorectal cancer . ^^^ The rate of cell loss owing to apoptosis is mediated by competitive dimerization with selective pairs of cell death antagonists ( Bcl 2 , Bcl 10 ( L ) ) and agonists ( Bax , Bad ) . ^^^ We analyzed the expression of Bcl 2 , Bcl 10 ( L ) , Bax , and Bad in normal appearing mucosa and colorectal tumor tissues by Western blotting after immunoprecipitation . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Temporally associated with this increase in apoptosis was augmented expression of pro apoptotic molecules that included Fas , Bax , and Bcl XS . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The increase in cell death of late erythroid cells is independent from the proapoptotic factor Bax , as demonstrated in conditional double mutant mice for Bcl 10 and Bax . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
There was no correlation between expression of members of the Bcl 2 family ( Bcl 2 , Bcl xL , Bax , and Bak ) and TRAIL sensitivity . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
After PDT , expression of Bcl 2 , Bcl 10 ( L ) , Bax , and Bak was also examined in cell lysates by Western blot analysis . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The level of expression of Bax in cells treated with either of these chalcones was markedly elevated and the level of Bcl XL decreased slightly . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The release of cytochrome c can be influenced by different Bcl 2 family member proteins , including , but not limited to , Bax , Bid , Bcl 2 , and Bcl 10 ( L ) . ^^^ Bax and Bid potentiate cytochrome c release , whereas Bcl 2 and Bcl 10 ( L ) antagonize this event . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
This is accompanied by progestin up regulation of the antiapoptotic protein bcl xL , no effect on the proapoptotic protein bax , and , surprisingly , diminution of the antiapoptotic protein bcl 2 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NSAIDs inhibited the expression of the antiapoptotic protein Bcl XL , resulting in an altered ratio of BAX to Bcl XL and subsequent mitochondria mediated cell death . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Consistent with this , overexpressing active Akt rescues cells from apoptosis without altering expression levels of endogenous Bcl 2 , Bcl 10 , or Bax . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We studied the expression of several genes involved in differentiation , apoptosis and chemoresistance : ets 1 , bax , bcl 2 , bag 1 , bcl 10 , mdr 1 and mrp . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The effect of TBI on regional cellular patterns of expression of survival promoting proteins such as Bcl 2 , Bcl xL , and extracellular signal regulated kinases , and death inducing proteins such as Bax , c Jun N terminal kinase , tumor suppressor gene , p 53 , and the caspase family of proteases are reviewed . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Messenger RNA expression levels of c myc , p 21 , bax , bcl 2 , and bcl 10 were not changed by the treatment with troglitazone . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Immunohistochemical stains for cytokeratins , involucrin , and apoptosis related proteins such as Bcl 2 , Bcl 10 ( L ) , and Bax were done . ^^^ Both Bcl 10 ( L ) and Bax were demonstrated in the nucleated cells adjacent to the ghost cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
PURPOSE : The present study was undertaken to investigate the prognostic and predictive relevance of the expression of apoptosis related proteins Bax , Bcl 10 ( L ) , and Mcl 1 in advanced ovarian cancer . ^^^ PATIENTS AND METHODS : Tumor biopsies from 185 consecutive and homogeneously treated patients with stage 3 ovarian cancer were examined immunohistochemically for the expression of Bax , Bcl 10 ( L ) and Mcl 1 proteins . ^^^ RESULTS : Sixty six percent of cancer cases expressed Bax , 62 % Bcl 10 ( L ) , and 53 % Mcl 1 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Western blot analysis revealed that the content of Bcl 10 ( L ) ( but not of Bcl 2 , BAX , Bad , and Bim ) significantly decreased in thymocytes after CLP . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bax and Bcl 10 ( L ) levels did not differ between melanoma cells or melanocytes and were unaffected by the addition of TPA . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Western blot analysis did not display variations in the expression of p 53 , Bcl 2 , Bcl XL , and Bax proteins during the treatment with AMD and DEA . ^^^ These data indicate that AMD induces cytochrome c release from mitochondria , triggering apoptosis through an iodine independent mechanism , and that this process is not mediated by modulation of p 53 , Bcl 2 , Bcl XL , or Bax protein expression and does not involve the generation of free radicals . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Selective light induced modulation of bcl XL and bax expressions in indocyanine green loaded U 937 cells : effects of continuous or intermittent photo sensitization with low IR light using a 805 nm diode laser . ^^^ In contrast , when the photostimulation was achieved by means of several consecutive pulses , we observed not only a remarkable increase in Bax but also a noticeable abatement in Bcl XL expression . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The resistance of U 266 cells to anti Fas did not appear to reflect dysregulation of Bcl 2 , Bcl 10 ( L ) , and Bax , because these proteins were expressed in both RPM 18226 and U 266 cells to similar levels . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bax consists of 9 alpha helices where the assembly of helices alpha 1 through alpha 8 resembles that of the apoptosis inhibitor , Bcl 10 ( L ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Inhibition of Bcl XL function by overexpression of Bax or administration of antisense oligonucleotides against Bcl XL mRNA resulted in sensitization of Panc 1 cells to TRAIL and PancTuI cells to anti CD 95 antibody induced cell death . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Expression of other apoptosis related genes ( bcl 2 , bcl XL , bax , bad , caspase 3 ) was not affected by light exposure or the lack of c Fos in knockout mice . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Because cell survival and apoptosis are regulated , in part , by the relative abundance of proteins of the Bcl 2 family , we hypothesized that lung cells dying during exposure would show increased expression of pro apoptotic members , such as Bax , whereas surviving cells would have increased expression of anti apoptotic members , such as Bcl 10 ( L ) . ^^^ The hypothesis is tested in the current study by determining which Bcl 2 genes are regulated by hyperoxia , with specific focus on correlating expression of Bax and Bcl 10 ( L ) with morphologic evidence of apoptosis or necrosis . ^^^ Adult mice exposed to greater than 95 % oxygen concentrations for 48 to 88 hours had increased whole lung mRNA levels of Bax and Bcl 10 ( L ) , no change in Bak , Bad , or Bcl 2 , and decreased levels of Bcl w and Bfl 1 . ^^^ In situ hybridization revealed that hyperoxia induced Bax and Bcl 10 ( L ) mRNA in uniform and overlapping patterns of expression throughout terminal bronchioles and parenchyma , coinciding with TUNEL staining . ^^^ Unexpectedly , Western analysis demonstrated increased Bcl 10 ( L ) , but not Bax , protein in response to hyperoxia . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
A dose and time dependent increase in apoptotic cells in the DEA NO treated culture was also observed , with a concomitant increase in the proapoptotic Bax protein levels and a reduction in the ratio between Bcl xL and Bcl xS proteins . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Both anti apoptotic ( Bcl W , Bcl 10 ( L ) ) and pro apoptotic ( Bad , Bak , Bax ) members of the Bcl 2 family were expressed in developing skeletal muscle in vivo . ^^^ Loss of Bcl 2 did not affect expression of other family members , because neonatal muscles of wild type and Bcl 2 null mice had similar amounts of Bcl 10 ( L ) , Bcl W , Bad , Bak , and Bax mRNAs . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In separate experiments , brains of sham operated control and HI only animals and animals subjected to HI plus C 2 ceramide or DMSO infusion were sampled 6 hours , 24 hours , and 5 days after treatments and analyzed for Bcl 2 , Bcl xl , and Bax expression ( Western blotting ) , and apoptosis ( TUNEL assay ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
To examine Bcl 2 and Caspase family dependent apoptotic pathways in telencephalic neurons , we compared the effects of cytosine arabinoside ( AraC ) , a known neuronal apoptosis inducer , on wild type , Bcl 10 ( L ) , Bax , Caspase 9 , Caspase 3 , and p 53 deficient telencephalic neurons in vitro . ^^^ AraC caused extensive apoptosis of wild type and Bcl 10 ( L ) deficient neurons . p 53 and Bax deficient neurons showed marked protection from AraC induced death , whereas Caspase 9 and Caspase 3 deficient neurons showed minimal or no protection , respectively . ^^^ In total , these results indicate a transition from Caspase 9 to Bax and Bcl 10 ( L ) mediated neuronal apoptosis . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The substitution of the C terminus of bax by that of bcl xL does not affect its subcellular localization but abrogates its pro apoptotic properties . ^^^ We report here that a substitution of the C terminal end of pro apoptotic bax by that of anti apoptotic bcl xL ( baxCxL ) does not modify its association with mitochondria in human and rat cells or in Saccharomyces cerevisiae . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We assessed the protein expression levels of bcl 2 , bax , bcl xL , and bcl xS in a group of 51 endometrial cancers and 8 normal samples as well as in 59 cervical neoplasms and in 15 normal cervical tissues . ^^^ Expression of bcl 2 , bax xL , and bcl xS in endometrial and cervical tissues . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The present study examines the contributions of apoptosis related proteins ( Bcl 2 , Bcl XL , Bax , and p21WAF1 / CIP1 ) in the regulation of T cell death induced by butyric acid , using p 53 knock out ( p 53 / ) and wild type ( p53+ / + ) mice . ^^^ These results suggest that butyric acid mediated apoptosis of murine T cells takes place via a pathway that is independent of p 53 , and is followed by the p 53 regulated proteins Bax and p21WAF1 / CIP1 , which lower the levels of the apoptosis antagonists Bcl 2 and Bcl XL in cells . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
RESULTS : The techniques used herein determined accumulation of paclitaxel / PSC 833 induced apoptotic cells with sub G 0 ( hypodiploid ) DNA content and blocked in the G2 / M phase of the cell cycle , internucleosomal DNA fragmentation , poly ( ADP ribose ) polymerase cleavage , Bcl 2 modulation and Bax up regulation , without any significant alterations in the levels of Bcl xL , CD95 / Fas or Fas L proteins . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Since the Bcl 2 family of proteins constitutes a critical checkpoint in apoptosis , acting upstream of the apoptotic machinery , we investigated the expression of six Bcl 2 homologs ( Bcl 2 , Bcl 10 ( L ) , Mcl 1 , Bax , Bak , Bad ) and one non homologous associated molecule ( Bag 1 ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The expression of proapoptotic ( Bad , Bak , Bax ) and antiapoptotic ( Bcl 2 , Bcl XL ) genes was analyzed by quantitative RT PCR . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We found that a mutant , Bcl 10 ( L ) ( F131V ) , which was previously reported to have impaired binding capacity , can bind to Bax almost as strongly as wild type Bcl 10 ( L ) . ^^^ However , non ionic detergent induces a conformational change in the Bcl 10 ( L ) ( F131V ) mutant and causes it to lose Bax binding capacity . ^^^ Wild type Bcl 10 ( L ) , on the other hand , is more resistant to detergent induced effects and retains its ability to bind Bax in the presence of detergent . ^^^ Since it has been shown that the Bcl 10 ( L ) ( F131V ) mutant has nearly the same anti apoptotic activity as wild type Bcl 10 ( L ) , it would be likely that the Bcl 10 ( L ) ( F131V ) mutant can adopt the wild type conformation , rather than the detergent induced conformational state and can bind to Bax in vivo . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bcl 2 gene and its family genes Bax , Bcl Xl as well as Fas / Apo 1 and their clinical significance in acute leukemia . ^^^ OBJECTIVE : To study the suppressing genes of apoptosis , namely Bcl 2 , its family genes Bax , Bcl Xl , and the inducing gene of apoptosis Fas / Apo 1 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Using immunofluorescence and Western blot analysis , we show that whilst Apaf 1 is a predominantly cytoplasmic protein , Bcl 2 , Bcl xL and Bax mostly reside on nuclear / ER and mitochondrial membranes . ^^^ This pattern of localization is maintained when the proteins are co expressed in both normal and apoptotic cells , suggesting that Bcl 2 , Bcl xL or Bax do not significantly sequester cytoplasmic Apaf 1 to intracellular membranes . ^^^ Based on these data , we propose that Apaf 1 is not a direct , physiological target of Bcl 2 , Bcl xL or Bax . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
ONYX 015 induces increased pro apoptotic BAX and reduced anti apoptotic BCLX ( L ) in parental cells , but not in the resistant derivative A2780 / cp70 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Expression of Tax in a human T cell line , Jurkat , induced the expression of the Bcl xL gene , but did not significantly affect the expression of the other apoptosis related genes , Bcl 2 and Bax . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
METHODS : Five pancreatic cell lines were investigated for the expression of FasL / Fas , DcR 3 , DR 4 , DR5 / TRAIL , DcR 1 , DcR 2 , and other death pathways related molecules such as Bax , bcl xL , bcl 2 , FADD , and caspase 3 by flow cytometry , immunoblotting , and RT / PCR , both semiquantitative and real time ( TaqMan ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
METHODS AND RESULTS : For immunohistochemistry , tissue sections of 32 patients were treated with an antigen retrieval METHOD : Primary antibodies against the apoptosis related proteins , bcl 2 , bcl 10 , bax , and bak were applied . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The deficiency of PAI 1 in the medium caused a significant reduction in Bcl 2 and Bcl XL mRNAs and an increase in Bcl XS and Bax mRNAs in PC 12 neurons at 3 h . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We also investigated intracellular levels of Bcl 2 , bcl xl and bax in CD 4 ( + ) and CD 8 ( + ) CVI T cells , as well as the bax / Bcl 2 ratio , using flow cytometry techniques but could not detect any differences between CVI and normal subjects . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
ATF 3 strongly downregulated CRE dependent transcription , while ATF 3 did not affect the expression levels of Bcl 2 , Bcl 10 , or Bax . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Apoptosis induced in the IL 3 dependent murine pro B lymphocytic ( FL5 . 12 ) cell line by the 5 lipoxygenase activating protein inhibitor MK 886 is accompanied by the rapid loss of the anti apoptotic bcl 10 ( L ) and bcl 2 , but not the proapoptotic bax proteins ( Datta et al . , J . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We therefore assessed expression levels of the anti apoptotic proteins BCL 2 and BCL XL and the pro apoptotic proteins BAX and BCL XS in T / null cell ALCL using immunohistochemical methods and correlated the findings with ALK expression and apoptotic rate ( AR ) , the latter assessed by a modified Tdt mediated dUTP nick end labeling assay . ^^^ ALK+ and ALK ALCLs also showed significant differences in expression of BCL XL , BAX , and BCL XS . ^^^ ALK+ tumors less commonly had a high level of BCL XL ( 1 of 17 versus 14 of 35 , P = 0 . 01 ) , and more commonly had high levels of BAX ( 13 of 18 versus 15 of 36 , P = 0 . 05 ) , and BCL XS ( 11 of 16 versus 12 of 31 , P = 0 . 05 ) compared with ALK tumors . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Characterization of the resulting clones for inhibitors of TRAIL induced death ( ITIDs ) led to the isolation of c FLIP ( S ) , Bax inhibitor 1 , and Bcl XL as candidate suppressors of TRAIL signaling . ^^^ These results suggest a key role for c FLIP ( S ) , Bcl XL , and Bax in determining tumor cell sensitivity to TRAIL . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
As IL 3 removal also down regulates expression of Bcl 10 , we examined the relationship between Bcl 10 decrease and Bax membrane association . ^^^ Inhibition of IL 3 signalling via PI 3 kinase and MEK1 / 2 resulted in cells with minimal Bcl 10 , which remained viable with soluble Bax . ^^^ However BAF 3 derived cells , which maintained Bcl 10 expression without IL 3 , also remained viable with soluble Bax on IL 3 removal . ^^^ Therefore a decrease in Bcl 10 is necessary , though not sufficient , for Bax membrane association on IL 3 removal . ^^^ Thus , apoptosis after IL 3 removal requires a decrease in Bcl 10 and Bax membrane association , whereas that induced by cytotoxic drugs does not . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Western blotting analysis and flow cytometric studies revealed that HGF inhibited doxorubicin and etoposide induced decreases in the levels of the anti apoptotic proteins Bcl 10 ( L ) , and to a lesser extent Bcl 2 , without inducing changes in the pro apoptotic Bax protein . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
BACKGROUND : The purpose of the present study was to examine the expression of cell cycle regulators [ p 53 , p21WAF1 / CIP1 ( p 21 ) , and Rb ] and apoptosis related proteins Bax and Bcl 10 ( L ) and to evaluate the relationship between their expressions and clinicopathological findings in patients with superficial squamous cell carcinomas of the esophagus . ^^^ METHODS : We immunohistochemically investigated the expression of p 53 , p 21 , Rb , Bax , and Bcl 10 ( L ) in 79 patients with superficial esophageal carcinoma . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Expression of bcl 2 , bax and bcl xl in human gliomas : a re appraisal . ^^^ We have analyzed the expression of the anti apoptotic proteins bcl 2 , bcl xl and that of bax , a pro apoptotic protein , in human WHO grade 2 astrocytomas ( LGA ) and WHO grade 4 glioblastoma multiforme ( GBM ) . ^^^ Confocal analyses provide us with another possible level of complexicity in the regulation of apoptosis in these tumors , as these markers exhibited different subcellular localizations : bcl 2 was strictly associated with mitochondria and bcl xl was present in both cytosolic and mitochondrial compartments while bax was found essentially in the cytosol of the tumoral cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
During the induction of chemoresistance , the appearance of a functional P glycoprotein ( P gp ) , in addition to the expression of anti apoptotic Bcl 2 , Bcl XL and pro apoptotic Bax proteins was assessed . ^^^ In addition , the synthesis of Bcl 2 appeared to be replaced by Bcl XL while that of Bax remained unchanged . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Additionally , U 69593 increased the content of the anti apoptotic members of the Bcl 2 family of proteins , the Bcl 2 and Bcl 10 ( L ) , whereas it had no significant effect on the apoptosis promoting homologues Bax , Bcl 10 ( S ) and Bak . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Emodin induced apoptosis of CH 27 cells does not involve modulation of endogenous Bcl 10 ( L ) protein expression , but appears to be associated with the increased expression of cellular Bak and Bax proteins . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The neurons died by a caspase dependent mechanism after inhibition of PI 3 kinase , and were also killed by antisense Bcl xL and antisense Bcl 2 or by overexpression of Bcl xS , Bad , and Bax . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Using mid gestation human jejunum and colon organotypic cultures , we analyzed the impact of growth factors ( namely insulin ; 10 microg / ml ) and pharmacological compounds that inhibit signal transduction molecules / pathways ( namely tyrosine kinases , Fak , P 13 K / Akt , and MEK / Erk ) on cell survival and Bcl 2 homolog expression ( anti apoptotic : Bcl 2 , Bcl 10 ( L ) , Mcl 1 ; pro apoptotic : Bax , Bak , Bad ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Specifically , this report examined expression of apoptotic promoters Bax and Bad and apoptotic inhibitors Bcl 2 and Bcl 10 ( all members of the Bcl 2 protein family ) . ^^^ Expression of Bcl 2 , Bcl 10 , Bax , and Bad and the extent of apoptosis were determined by flow cytometric analysis of freshly isolated cells and cells cultured with TGF beta ( 1 ) and FL effectors . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In this study , phosphatase inhibitor okadaic acid induces apoptosis in U 937 cells via a mechanism that appears to involve caspase 3 activation , but not modulation of Bcl 2 , Bax , and Bcl 10 ( L ) expression levels . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The expression of regulating molecules was analyzed by using western blotting for p 53 , Bcl 2 , Bax , Bcl XL , Bcl XS , and p 21 ( WAF1 / CIP1 ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
While bcl 2 , bax , NFkappaB and p 53 gene expression were spontaneously upregulated , bcl xL and p21WAF1 gene expression decreased and IkappaB remained unchanged during the activation process in vitro . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The increased expressions of Bax and Bad were detected in HAECs incubated for 24 h with gly ox HDL , but gly ox HDL failed to interfere with the expression of Bcl 2 and Bcl 10 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Furthermore , ceramide inhibits the expression of the antiapoptotic protein Bcl xL with an increase in the ratio of Bax to Bcl xL . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bcl 2 , Bcl 10 , and Bax expression by immunohistochemistry in inclusion body myositis : a study of 27 cases . ^^^ CONTEXT : Bcl 2 , Bcl 10 , and Bax are among the variety of proteins that have been described as being involved in the regulation of apoptotic cell death . ^^^ Bcl 2 and Bcl 10 ( L ) inhibit apoptosis , and Bax is proapoptotic . ^^^ OBJECTIVE : To evaluate the expression of Bcl 2 , Bcl 10 , and Bax in inclusion body myositis ( IBM ) . ^^^ We examined muscle specimens from 27 patients ( 17 men , 10 women ) with IBM to evaluate Bcl 2 , Bcl 10 , and Bax expression by immunohistochemistry . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Following AdBax / SB and AdBak / SB , a decrease of the AAP bcl xl was noted in combination with increases in PAP bax and bak . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
HuH 7 cells do not express Bcl 2 ; however , down regulation of Bcl xL expression preceded activation of the caspase cascade in GGOH treated HuH 7 cells , while Bax expression was not changed by GGOH treatment . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
METHODS : We investigated the expression of Bcl 2 , Bcl 10 , and Bax using immunohistochemistry in 86 ESCCs , and scored the expression by the weighted score . ^^^ The inverse relationship between Bcl 2 and Bcl 10 expression was detected ( P = 0 . 001 ) , while the positive one between Bcl 10 and Bax expression was detected ( P = 0 . 014 ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
BCL 2 , BCL 10 ( L ) sequester BH 3 domain only molecules preventing BAX and BAK mediated mitochondrial apoptosis . ^^^ Comparison of wild type versus mutant BCL 2 , BCL 10 ( L ) indicates these antiapoptotics sequester BH 3 domain only molecules in stable mitochondrial complexes , preventing the activation of BAX , BAK . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In conclusion , by inducing apoptosis , by enhancing apoptosis induced by fludarabine , by suppressing Bcl 2 , Bcl 10 and by inducing Bax expression , PDE 4 inhibitors may add a new therapeutic option for patients with B CLL . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
GDNF protects against aluminum induced apoptosis in rabbits by upregulating Bcl 2 and Bcl XL and inhibiting mitochondrial Bax translocation . ^^^ Coadministration of glial cell neuronal derived factor ( GDNF ) inhibits these Bcl 2 and Bax changes , upregulates Bcl XL , and abolishes the caspase 3 activity . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
When colonization occurs : ( 1 ) neuregulin beta ligand is expressed and binds to an ErbB 2 ErbB3 receptor tyrosine kinase heterodimer on primordial germ cells ; ( 2 ) Vasa , an ortholog of the Drosophila gene vasa , member of an ATP dependent RNA helicase of the DEAD ( Asp Glu Ala Asp ) box family protein is also expressed by primordial germ cells ; ( 3 ) Bcl 10 ( cell survival factor ) and Bax ( cell death factor ) join forces to modulate the first burst of primordial germ cell apoptosis ; ( 4 ) Cadherins , integrins , and disintegrins bring together primordial germ cells and somatic cells to organize testis and ovary . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
DMS inhibited bcl 10 ( L ) and bak but not bax gene expression , while BSOCOP potentiated bax mRNA synthesis immediately after application . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Expression and redistribution of cellular Bad , Bax , and Bcl 10 ( L ) protein is associated with VCD induced ovotoxicity in rats . ^^^ However , consistent with a Bax mediated mechanism of apoptosis , the relative ratio of Bax / Bcl 10 ( L ) in the mitochondrial fraction of small preantral follicles was significantly increased by VCD dosing ( 1 . 62 + / 0 . 21 , VCD / control , P < 0 . 05 ) . ^^^ These data provide evidence that the apoptosis induced by VCD in ovarian small preantral follicles of rats is associated with increased expression of Bad protein , redistribution of Bcl 10 ( L ) protein and cytochrome c from the mitochondria to the cytosolic compartment , and an increase in the Bax / Bcl 10 ( L ) ratio in the mitochondria . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bax and Bcl 10 ( L ) expression are not related to prognosis in patients with advanced esophageal squamous cell carcinoma . ^^^ Bax and Bcl 10 ( L ) genes play an important role in the apoptotic pathway . ^^^ The positive rates of p 53 , Bax , and Bcl 10 ( L ) were 42 . 3 , 38 . 7 , and 46 . 8 % , respectively . ^^^ The expression of both Bax and Bcl 10 ( L ) was not related to clinicopathological findings , including survival . ^^^ Neither Bax nor Bcl 10 ( L ) expression correlated with p 53 overexpression . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
After neutrophils were incubated with HPWE , expression of Bcl 2 family [ antiapoptotic ( Bcl 2 , Bcl XL and Mcl 1 ) and proapoptotic ( Bax , Bak and Bcl XS ) ] was determined by RT PCR and Western blotting , respectively . ^^^ The expression of Bax and Bak was upregulated and Bcl 2 , Bcl XL and Mcl 1 downregulated in HL 60 cells during neutrophilic differentiation . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
This is closely associated with [ 1 ] the down regulation of Bcl 2 and Bcl xL proteins and [ 2 ] upregulation of Bax and Bad , whose gene products are known to be involved the regulation of apoptosis in mammalian cells . ^^^ These findings suggest that modulation of Bax , Bcl xL , Bcl 2 and Bad proteins by ICI may be , in part , responsible for the anti proliferative and apoptotic effect of ICI seen clinically and in animal models . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Overexpression of Bcl 10 ( L ) or treatment with antisense oligodeoxynucleotides targeted against Bax significantly inhibited radiation induced apoptosis in MIA PaCa 2 / RII but not in MIA PaCa 2 / Vector cells , suggesting that Bax induction is necessary for radiation induced TGF beta signaling mediated apoptosis . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
At that time , the whole kidney mRNA expression of the apoptosis inhibitory genes bcl xL and bcl 2 , as well as that of the apoptosis promotor bax , was significantly reduced . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
A significant decrease in BCL XL protein expression was noted with BAK , BAX , and BCL 2 unchanged , and this was corroborated at the transcriptional level with selectively decreased bcl xl mRNA production after sodium butyrate exposure . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Finally , the apoptotic regulatory molecules Bcl 2 , Bcl xL , and Bax , do not appear to play a significant role in the regulation of eosinophil apoptosis in the schistosome granuloma . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The prognostic significance of apoptosis associated proteins BCL 2 , BAX and BCL 10 in clinical nephroblastoma . ^^^ Various apoptosis associated regulatory proteins , such as Bcl 2 , Bax and Bcl 10 , may contribute to the rate of apoptosis in neoplasia . ^^^ Generally , Bcl 2 , Bax and for Bcl 10 ( S / L ) were expressed in the blastemal and epithelial components of Wilms ' tumour . ^^^ Immunoreactive blastema cells were found in 53 % , 41 % and 38 % of tumours for Bcl 2 , Bax and for Bcl 10 ( S / L ) , respectively . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In tissue from the frontal cortex , western blot analysis revealed that phencyclidine treatment increased Bax and decreased Bcl 10 ( L ) proteins . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
METHODS : TAD 2 cells were treated with lovastatin to induce apoptosis , and expression of p 53 , Bc 1 2 , Bcl XL and Bax was analyzed by Western blot . ^^^ RESULTS : p 53 , Bc 1 2 , Bcl XL and Bax protein expression were unchanged during apoptosis . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
As2O3 had no effect on the expression of the apoptosis related genes like Bcl 2 , Bcl xL / S , Bax , ICH 1L , p 53 , PARP , either , but downregulated PML protein expression in K 562 cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Treatment with etoposide did not decrease the ratio of anti apoptotic Bcl 2 and Bcl xL proteins to pro apoptotic Bax protein . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Importantly , 16 10A1 could retard the growth of lymphomas and favored the up regulation of pro apoptotic molecules caspase 3 , caspase 8 , Fas , FasL , Bak , and Bax and down regulation of anti apoptotic molecule Bcl 10 ( L ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Aloe emodin induced apoptosis of CH 27 cells involved modulation of the expression of Bcl 2 family proteins , such as BclX ( L ) , Bag 1 , and Bak , and was associated with the translocation of Bak and Bax from cytosolic to particulate fractions . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The search for the corresponding effector genes revealed that the expression of FKBP 25 , FKBP 38 and FKBP 52 ( analysis by reverse transcription polymerase chain reaction ( RT PCR ) did not change following H ( 2 ) O ( 2 ) or FK 506 , and this was also true for the expression of apoptosis related genes caspase 3 , bax , bcl 2 and bcl xL ( analysis by Multiplex PCR ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In comparison , strong expression of Bax , Bak and p 21 ( waf1 / cip1 ) and suppressed expression of Bcl 2 , Bcl 10 ( L ) and COX 2 were observed in the Mn SOD antisense group and the expression pattern of these proteins was the inverse in the empty vector group . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
At the later stage of cell death ( < 32 36 hr ) , a specific cleavage of Bax and fodrin appeared that was completely blocked by calpain inhibitor or by Bcl 10 ( L ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
EGCG also caused a decrease in the Bcl 2 and Bcl 10 ( L ) proteins , an increase in the Bax protein , and activation of caspase 9 , suggesting that EGCG induces apoptosis via a mitochondrial pathway . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Targeted gene disruptions of members of the bcl 2 and caspase gene families have demonstrated particularly significant roles for bcl 10 , bax , caspase 9 and caspase 3 in mammalian brain development . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Densitometric analysis of western blots revealed that the ratios of both Bcl 10 ( L ) / Bax and Bcl 2 / Bax were significantly increased ( > 2 . 5 fold ) in arsenic transformed cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We examined the effects of cadmium on the bcl 2 family of proteins bcl 2 , bax , bad , and bcl xS / L in cadmium induced cytotoxicity . ^^^ Western blot analyses revealed that cadmium markedly increased endogenous bcl 2 protein ( to 3 4 times the level in wild type cells ) earlier than metallothionein induction , but that the metal did not enhance the induction of bax , bad , or bcl xS proteins . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
RT PCR analysis of two regulators of apoptosis , Bcl 10 ( L ) ( anti apoptotic ) and Bax ( pro apoptotic ) , revealed equivalent increases in levels of expression . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Moreover , while expression levels of apoptosis inhibitors , Bcl 2 and Bcl XL were increased following UC treatment , that of an apoptosis promoter , Bax , was decreased . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Expression of both anti apoptotic ( such as Bcl 2 and Bcl 10 ( L ) ) and proapoptotic ( such as Bax ) proteins is markedly elevated in the liver of human ALD and chronically ethanol fed IL 6 ( + / + ) mice . ^^^ On the contrary , induction of Bcl 2 and Bcl 10 ( L ) is not observed in the liver of chronically ethanol fed IL 6 ( / ) mice , whereas expression of Bax protein remains elevated . ^^^ Injection of IL 6 markedly induces expression of Bcl 2 and Bcl 10 ( L ) but not Bax in the liver . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
As biomarkers , expression of Bcl 2 , Bax , Bcl 10 , and the accumulation of P 53 protein were also studied immunohistochemically . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The ratios of the apoptosis regulating proteins Bcl 2 to Bax and Bcl 10 ( L ) to Bax were higher in cells overexpressing wild type , but not NLS mutated , PTHrP compared with control cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
PURPOSE : To detect cell specific apoptosis factors , Fas and Fas ligand , and the common intracellular apoptosis modulators , interleukin 1 beta converting enzyme ( ICE ) like protease ( caspase 1 ) , Bcl 2 , Bcl xL and Bax in lens epithelial cells ( LEC ) of human cataracts . ^^^ METHODS : Reverse transcriptase polymerase chain reaction ( RT PCR ) was used to detect Fas , Fas ligand , caspase 1 , Bcl 2 , Bcl xL and Bax , after cDNA was synthesized from the total RNA isolated from human cataractous LEC obtained by capsulotomy during cataract surgery . ^^^ RESULTS : Fas , caspase 1 , Bcl 2 , Bcl xL and Bax mRNA were detected by RT PCR . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The tumor response to low dose FP treatment was associated with the induction of apoptotic cell death and with the overexpression of apoptosis related genes , such as Bax and Bcl Xs , in cancer cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Proapoptotic ( p 53 and Bax ) , Bcl XL and cyclooxygenase ( COX ) proteins have been implicated in betaA induced neuronal death . ^^^ However , in this study the protective effects of EGCG seem to be independent of the regulation of p 53 , Bax , Bcl XL and COX proteins . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
However , in HCa 1 , the application of a priming dose increased radiation induced Bcl XL and Bcl XS , but not Bcl 2 or Bax . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
This effect was not apparently mediated through downregulation of the PK hBcl 2 transgene or via delocalization of the Bcl 2 protein , and a direct interaction of HBx with Bcl 2 , Bcl 10 ( L ) or Bax could not be evidenced in yeast two hybrid assays . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Analysis of mitochondria associated proteins Bax and Bcl xl in hemin and CO exposed rats showed significant responses , revealing interactions with apoptotic pathways . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Dynamics of expression of apoptosis regulatory proteins Bid , Bcl 2 , Bcl 10 , Bax and Bak during development of murine nervous system . ^^^ We have used immunohistochemistry and immunoblotting to examine the expression of Bid and four other Bcl 2 family proteins ( Bcl 2 , Bcl 10 , Bax and Bak ) in the developing and adult murine central nervous system ( CNS ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The aim of our study was to determine whether mRNA levels of Mdm 2 , Bcl 2 , Bcl 10 ( L ) , Bad , and Bax are independent prognostic parameters for outcome . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The expression of pro and anti apoptotic proteins p 53 , p 21 , MDM 2 , BCL 2 , BCL 10 ( L ) , BCL 10 ( S ) , and BAX , and caspase 3 activity was determined in circulating blasts collected from the peripheral blood of children with leukemia prior to , and at serial time points following chemotherapy . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Expression of Akt did not alter the levels of Bax , Bcl 2 , Bcl 10 ( L ) , or phosphorylated JNK under the conditions used , suggesting that there were alternative mechanisms for Akt in the suppression of Bax translocation . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
IFN gamma or TRAIL treatment alone did not change expression of other pro or antiapoptotic proteins such as DR 4 , DR 5 , FADD , Bax , IAP 1 , XIAP , Bcl 2 , and Bcl XL . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Finally , adult mice deficient for the CD 40 receptor demonstrate neuronal dysfunction as evidenced by decreased neurofilament isoforms , reduced Bcl 10 ( L ) : Bax ratio , neuronal morphological change , increased DNA fragmentation , and gross brain abnormality . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Expression of apoptosis related genes such as Bax , Bcl 10 ( L ) , Bcl 2 or caspase 8 were reduced by p27Kip1 transduction compared with that of beta actin , whereas p27Kip1 transduction did not affect the expression level of Fas or the Fas ligand . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
OBJECTIVE : To determine the role of apoptosis related proteins ( Myc , Bax , Bcl 2 , and Bcl 10 ( L ) ) in muscular damage in obstructed rat ureters . ^^^ The numbers of apoptotic cells in the smooth muscle layer correlated significantly with the expressions of Myc and Bax ( r = 0 . 7360 and 0 . 7432 , respectively ; both P < 0 . 005 ) , and with the expression index of Bax / Bcl 2 and Bax / Bcl 10 ( L ) ( r = 0 . 8909 and 0 . 8592 , respectively ; both P < 0 . 001 ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The expression of Bcl 2 family proteins ( Bcl 2 , Bcl 10 , Bax , Bak and Bim ) in human lymphocytes . ^^^ We investigated the expression of Bcl 2 , Bcl 10 , Bax , Bak and Bim in human lymphocytes using flow cytometry . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Expression of Bcl 10 , Bcl 2 , Bax , and Bak in endarterectomy and atherectomy specimens . ^^^ The aim of this study was to determine the expression of Bcl 2 , Bcl 10 , Bax , and Bak in relation to apoptosis in advanced atherosclerotic lesions . ^^^ In all TUNEL positive apoptotic cells , Bax and Bak were present , while Bcl 10 was absent . ^^^ In conclusion , increased Bax and Bak coupled with lack / paucity of Bcl 2 and Bcl xL are associated with SMC apoptosis in advanced lesions . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Expression of Bcl 2 , Bcl 10 , Mcl 1 , Bax and Bak in human uterine leiomyomas and myometrium during the menstrual cycle and after menopause . ^^^ To investigate the expression of Bcl 2 , Bcl 10 , Mcl 1 , Bax and Bak proteins in human uterine leiomyomas and homologous myometrium during the menstrual cycle and after menopause . ^^^ The expression of Bcl 2 , Bcl 10 , Mcl 1 , Bax and Bak in leiomyomas ( n=24 ) and myometrial samples ( n=22 ) from women with leiomyomas was measured by immunohistochemistry and Western blot . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
METHODS : Bcl 2 , Bax , Bcl 10 , Fas ( CD 95 ) and tumor necrosis factor ( TNF ) receptor expression was determined by flow cytometry in control and mitomycin C treated Tenon fibroblasts . ^^^ RESULTS : Tenon fibroblasts constitutively express Bcl 2 , Bax , and Bcl 10 in culture . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In this study , we detected DNA fragmentation by the terminal deoxynucleotide transferase mediated dUTP nick end labeling ( TUNEL ) method and immunohistochemically examined the expression of Bcl 10 and Bax in psoriasis . ^^^ Whereas , in nonlesional and normal skin , only a few TUNEL positive cells were observed and only the lower epidermis showed positive staining for Bcl 10 and Bax . ^^^ A large number of TUNEL positive cells as well as Bcl xL and Bax positive cells were observed throughout the epidermis in psoriatic lesions . ^^^ The expression of bcl xL mRNA in cultured normal human keratinocytes stimulated or not with IFN gamma and PMA was suppressed by VD 3 in a dose dependent manner , and the expression of Bcl xL , but not Bax , in psoriatic lesional skin decreased after topical application of VD 3 for 4 weeks . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The expressions of bax protein and mRNA were increased and bcl 10 ( s ) mRNA became detectable after taxol treatment . ^^^ Bax and bcl 10 ( s ) participate in the taxol induced apoptosis of Jurkat cells . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Rat1a cells exposed to hyperoxia underwent apoptosis characterized by the release of cytochrome c , activation of caspase 9 , and nuclear fragmentation that was prevented by the overexpression of Bcl 10 ( L . ) Murine embryonic fibroblasts from bax ( / ) bak ( / ) mice were resistant to hyperoxia induced cell death . ^^^ We conclude that exposure to hyperoxia results in apoptosis that requires Bax or Bak and can be prevented by the overexpression of Bcl 10 ( L ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bcl 10 ( L ) and calyculin A prevent translocation of Bax to mitochondria during apoptosis . ^^^ Both Bcl 10 ( L ) and the protein phosphatase inhibitor calyculin A have been shown to prevent apoptosis , and here we investigated their impact on Bax translocation . ^^^ Both Bcl 10 ( L ) and calyculin A prevented Bax translocation and cytochrome c release . ^^^ Bcl 10 ( L ) is generally thought to heterodimerize with Bax to prevent cytochrome c release and yet they remain in different cellular compartments , suggesting that their heterodimerization at the mitochondria is not the primary mechanism of Bcl 10 ( L ) mediated protection . ^^^ Upon induction of apoptosis , Bax formed homo oligomers in the mitochondrial fraction with no evidence for cross linking to Bcl 2 or Bcl 10 ( L ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The predictive value of bcl 2 , bax , bcl xL , bag 1 , fas , and fasL for chemotherapy response in advanced breast cancer . ^^^ In 126 patients , histological blocks of primary tumors were available for immunohistochemical analysis of bax , bcl 2 , bcl xL , bag 1 , fas and fasL . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The expression of thymidylate synthase ( TS ) , p 53 , retinoblastoma protein ( Rb ) , Fas receptor , Fas ligand , bcl 2 , mcl 1 , bax , and bcl 10 was measured using immunohistochemistry . ^^^ The expression of bax , mcl 1 , and bcl 10 in normal mucosa was more apical than that seen in malignant cells , where a more diffuse expression pattern was seen ( p < 0 . 04 ) . ^^^ CONCLUSIONS : These results demonstrate that proliferation and apoptosis are disturbed during colorectal cancer progression , and this is accompanied by loss of Rb and Fas expression , the accumulation of p 53 and TS , and changes in the expression patterns of bax , mcl 1 , and bcl xl . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Ribonuclease protection assays compared the effects of acetaminophen and E 2 on expression of selected genes ( c myc , c fos , cyclin D 1 , bcl 2 , bax , gadd 45 , mcl 1 , p 53 , p 21 ( CIP1 / WAF1 ) , and bcl xL ) in E 2 responsive breast cancer ( MCF 7 ) and endometrial adenocarcinoma ( Ishikawa ) cells as well as in E 2 nonresponsive ( MDA MB 231 ) breast cancer cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Since no consistent differences in Bcl 2 , Bcl 10 ( L ) or Bax expression were seen in the STS and radiation resistant neuroblastomas , it suggests that a unique mitochondrial signaling factor ( s ) is responsible for the defect in cytochrome c release in this sub group of tumors . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The other ovary was used for immunohistochemical analysis of selected members of the B cell lymphoma / leukemia 2 family of protooncogenes ( Bax , Bcl 2 , Bcl 10 ) , proliferating cell nuclear antigen ( PCNA ) , and cyclin dependent kinase 2 ( Cdk 2 ) . ^^^ Further , the results indicate that Smad 3 may regulate the expression of Bax and Bcl 2 , but not Bcl 10 , Cdk 2 , and PCNA . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Real time quantitative RT PCR analyses revealed that mRNAs of Fas , Bcl xL , Bax and ICAD ( inhibitor of caspase 3 related DNase ) of the psoriatic involved epidermis were increased by 4 . 2 , 2 . 8 , 2 . 6 and 5 . 6 fold , respectively , compared with the uninvolved epidermis . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Requirement of BAX for TRAIL / Apo2L induced apoptosis of colorectal cancers : synergism with sulindac mediated inhibition of Bcl 10 ( L ) . ^^^ We additionally demonstrate that TRAIL / Apo2L induced death of p 53 ( + / + ) or p 53 ( / ) BAX proficient but not BAX deficient colorectal cancer cells is augmented by reducing nuclear factor kappaB dependent expression of Bcl 10 ( L ) with either a peptide that disrupts the inhibitor of kappaB kinase complex or the nonsteroidal anti inflammatory drug , sulindac sulfide . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Resistance of colon cancer cells to long term 5 fluorouracil exposure is correlated to the relative level of Bcl 2 and Bcl 10 ( L ) in addition to Bax and p 53 status . ^^^ In addition , we found that high levels of anti apoptotic Bcl 2 and Bcl 10 ( L ) proteins combined with a low level of Bax were correlated to high 5 FU resistance of wild type p 53 cell lines . ^^^ In conclusion , the relative levels of Bcl 2 , Bcl 10 ( L ) and Bax may altogether contribute to determine the resistance of a majority of colon tumor cells to long term 5 FU treatment , whatever their p 53 status . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
CONCLUSIONS : Overexpression of Bcl xl in cardiac myocytes failed to regulate Dox induced ROS generation and cardiac specific gene downregulation but inhibited apoptosis accompanied by reduction of Bax protein . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The mRNA expression levels of the bcl 2 genes family was changed as follows : bax increased up to 40 % in CCI vs the sham rats , while bcl 2 did not change ; bcl xS massively decreased ( by 70 % and 100 % ) , while bcl xL increased ( by 40 % ) in CCI rats . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Levels of bcl 2 , bcl 10 , bax , p 53 and p 21 were determined by Western blotting , and celi cycle analysis was determined by flow cytometry . ^^^ Neither IL 1 nor ceramide induced apoptosis in EEC , but they increased bcl 2 levels and decreased bax and p 21 levels without affecting bcl 10 and p 53 levels . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Within 24 h after 3 NP administration there were elevations in both bcl xl and bax . ^^^ However , bcl xl protein levels quickly returned to control levels while bax levels continued to increase , resulting in a detrimental bax / bcl xl ratio . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Tumor biopsy specimens at pretreatment status were examined for apoptosis related proteins such as p 53 protein , Fas , bax , bcl 10 , and apoptosis using immunohistologic methods . ^^^ RESULTS : p 53 mutations were identified in 20 ( 29 % ) of 70 patients . p 53 protein was overexpressed in 39 patients ( 56 % ) , Fas in 20 patients ( 29 % ) , bax in 40 patients ( 57 % ) , and bcl 10 in 33 patients ( 47 % ) . ^^^ Overexpression of bax was associated with negativity of bcl 10 ( P = 0 . 015 ) and with high AI ( P = 0 . 024 ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Indeed , DC activation effectively inhibited DC apoptosis , which was predominantly accompanied by the upregulation of Bcl 10 ( L ) and to a lesser extent Bcl 2 , while Bax and FLICE inhibitory protein ( FLIP ) remained unchanged . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Furthermore , rifampicin down regulated the expression of Bax and CD95L and up regulated the expression of Bcl 2 , Bcl xL , and Flice inhibitory protein L ( FLIPL ) ; however , rifampicin had no effect on CD 95 or XIAP expression . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bad , Bax , Bcl 10 ( S ) ) were reduced 2 4 fold in the resistant cell line , whereas the anti apoptotic proteins Bcl 2 and Bcl 10 ( L ) were expressed at similar levels in both cell lines . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Cellular commitment to apoptosis is partly regulated by the Bcl 2 family proteins , which includes the death antagonists Bcl 2 and Bcl 10 ( L ) , and death agonists Bax and Bad . ^^^ Cellular expression of Bcl 2 , Bcl 10 ( L ) , Bax or Bad in MS patients was independent of the expression of other apoptotic regulatory molecules , such as Fas receptor protein or FLIP . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
M 40403 also prevented NMDA induced nuclear transport of NF kappaB and increased expression of Bax relative to Bcl 10 ( L ) . ^^^ SN 50 was also able to block NMDA induced cell death as well as the increased Bax / Bcl 10 ( L ) ratio . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
IVIG decreased the intracellular expression of anti apoptotic proteins of the Bcl 2 family ( A 1 and Bcl XL ) while IVIG increased the intracellular expression of pro apoptotic proteins ( Bax and Bcl XS ) in the TNF alpha stimulated HUVECs . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
RANKL had no effect on H / RS cell survival in culture , and it did not modulate the expression of bcl 2 , bcl xL , bax , or inhibitors of apoptosis proteins . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Although protein expression of Fas , FADD , Bax , Bak , and Bcl 10 in the whole cell lysates was not changed by H pylori , Bax was decreased from mitochondria free cytosol suggesting that Bax was translocated into mitochondria . ( 3 ) Cell death and the activities of caspases 3 and 8 were promoted in MKN 45 cells stably expressing super repressor Ikappabetaalpha that inhibits NFkappaB activation . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Since the Bcl 2 family is critically involved in the regulation of apoptosis , we investigated the protein expression of Bcl 2 , Bcl 10 ( L ) , and Bax in peripheral blood mononuclear cells ( PBMC ) of 23 MS patients and 29 control subjects . ^^^ In contrast to Bcl 10 ( L ) , no differences were found in the protein expression of Bcl 2 and Bax between patients and controls . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
High mutation levels of cell cycle control genes such as p 53 , p 16 , p 21 , SMAD 4 , and cyclin D 1 are found , and there is abnormal expression of apoptotic genes , such as bcl 2 , bcl XL , and bax . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The function of the second domain is still unknown . vMIA does not share any significant amino acid sequence homology with Bcl 2 , and , unlike Bcl 2 or Bcl 10 ( L ) , it does not bind BAX or VDAC . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Apoptosis and expression of Bcl 2 , Bcl XL , and Bax in renal cell carcinomas . ^^^ The present study analyses the inter relationship between the expression of representatives of the anti apoptotic ( Bcl 2 , Bcl XL ) or pro apoptotic ( Bax ) Bcl 2 proteins , incidence of apoptosis , and mitosis in a selected small group of 22 graded RCCs that had paired normal renal tissue , or non neoplastic tissue in the renal biopsy specimen . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
By using a ribonuclease protection assay , the ratios of both pro and antiapoptotic mRNA ( bcl 10 , bcl 2 , bax , caspase 2 , and caspase 3 ) to the housekeeping glyceraldehyde phosphate dehydrogenase ( GAPDH ) gene were determined . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
MAIN OUTCOME MEASURES : We examined the expression of Bcl 2 , Bcl xl , Bax , caspase 3 , and inducible nitric oxide synthase in infiltrating mononuclear cells of colorectal cancer tissues and also in colorectal cancer tissues . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
To investigate the potential role of the BCL 2 gene family ( BAX , BCL 2 , MCL 1 , and BCL XL ) in ovarian cancer development and progression , mRNA expression levels of these genes were measured using semi quantitative PCR in epithelial ovarian tumor tissues and normal ovaries . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The Mtb induced apoptosis was associated with a speedy and transient increase in expression of Bax protein , a proapoptotic member of the Bcl 2 family , and a more prominent reduction in expression of the antiapoptotic protein Bcl 10 ( L ) . ^^^ Pretreatment with an inhibitor of NADPH oxidase distinctly suppressed the Mtb stimulated activation of caspase 3 and alteration of Bax / Bcl 10 ( L ) expression in neutrophils . ^^^ These results indicate that infection with Mtb causes ROS dependent alteration of Bax / Bcl 10 ( L ) expression and activation of caspase 3 , and thereby induces apoptosis in human neutrophils . ^^^ Mycobacterium tuberculosis promotes apoptosis in human neutrophils by activating caspase 3 and altering expression of Bax / Bcl xL via an oxygen dependent pathway . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Rasagiline increased the levels of bcl 2 and bcl 10 ( l ) mRNA at 100 10 nM and 100 10 pM , but not the level of pro apoptotic bax mRNA . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In addition , gene expression analysis revealed that EGCG prevented both the 6 OHDA induced expression of several mRNAs , such as Bax , Bad , and Mdm 2 , and the decrease in Bcl 2 , Bcl w , and Bcl 10 ( L ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Malignant pleural mesothelioma lines and tumors rarely express the antiapoptotic Bcl 2 protein but routinely express the antiapoptotic protein Bcl xl and the proapoptotic proteins Bax and Bak . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Our data demonstrated that Gyp induced apoptotic cell death was accompanied by up regulation of Bax , Bak and Bcl 10 ( L ) , and down regulation of Bcl 2 and Bad , while it had no effect on the level of Bag 1 protein . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NF kappaB mediated up regulation of Bcl 10 ( S ) and Bax contributes to cytochrome c release in cyanide induced apoptosis . ^^^ After cyanide ( 100 500 microm ) treatment for 24 h , two pro apoptotic Bcl 2 proteins , Bcl 10 ( S ) and Bax were up regulated as shown by western blot and RT PCR analysis . ^^^ The expression levels of two antiapoptotic Bcl 2 proteins , Bcl 2 and Bcl 10 ( L ) , remained unchanged after cyanide treatment , whereas the mRNA levels of Bcl 10 ( S ) and Bax began to increase within 2 h and their protein levels increased 6 h after treatment . ^^^ NF kappaB , a redox sensitive transcription factor activated after cyanide treatment , is responsible for the up regulation of Bcl 10 ( S ) and Bax . ^^^ SN 50 , which is a synthetic peptide that blocks translocation of NF kappaB from cytosol to nucleus , inhibited the up regulation of Bcl 10 ( S ) and Bax . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Immunoblotting for Bcl 2 family members revealed no significant changes in the expression levels of Bcl 2 , Bcl 10 ( L ) , Bax or Bak following gene or ' chemogene ' therapy with E2F 1 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Four molecules of the Bd 2 family ( BID , Bcl 2 , Bax , Bcl 10 ( L ) ) have been reported to be deaved during apoptosis , as has a cellular inhibitor of apoptosis ( XIAP ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In addition , it counteracted the effect of TNP BSA on the expression of the Bcl 2 family , resulting in down regulation of Bax and Bad and up regulation of Bcl XL . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Blood and liver were analyzed for plasma aminotransferase activity , liver histology , liver apoptotic nuclei , mRNA of several cytokines ( tumor necrosis factor [ TNF ] alpha , interleukin [ IL ] 1beta , IL 6 , and IL 10 ) , apoptotic ligands ( TRAIL ) , cytokine receptors ( TNFRp 55 ) , pro and antiapoptotic regulators / adaptors ( Fas receptor , FasL , FADD , TRADD , RIP , Bak , Bax , Bcl 10 , Bcl 2 and Bcl w ) , and caspase 8 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
MCF 7 cells were cultured with either 1 nM melatonin , 100 nM D 3 or its diluent to determine their effects on cell proliferation , cell viability , cell cycle phase distribution , population of apoptotic cells , and expression of p 53 , p21WAF1 , bcl 2 , bcl 10 ( L ) and bax proteins . ^^^ No significant changes in bcl 2 , bcl XL and bax mRNAs were detected after treatment with melatonin whereas in D 3 treated cells , a significant drop in bcl XL was observed . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In this study , we evaluated the expression patterns of Bcl 2 , Bcl xL , and Bax protein in 126 primary invasive breast carcinomas , and the association with other clinicopathological parameters . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We observed no detectable changes in the steady state levels of Bcl 10 ( L ) , Bax , and Bid , although TNF suppresses Bcl 2 expression . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
TUNEL staining detected apoptotic T cells at low frequency corresponding to an increased expression of the anti apoptotic molecules Bcl 2 and Bcl 10 ( L ) and a reduced expression of the pro apoptotic molecules Bad , Bax , and Fas ligand in CD 4 and CD 8 T cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We observed no detectable change in the steady state levels of Bax , Bcl 2 , and Bcl 10 ( L ) following raloxifene treatment . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Intracisternal administration of aluminum into rabbit brain induces cytochrome c release , decreases levels of the anti apoptotic proteins Bcl 2 and Bcl 10 ( L ) , increases levels of the pro apoptotic Bax , activates caspase 3 , and causes DNA fragmentation as measured by the TUNEL assay . ^^^ Pretreatment for 14 days with 7 mm of lithium carbonate in drinking water prevents aluminum induced translocation of cytochrome c , and up regulates Bcl 2 and Bcl 10 ( L , ) down regulates Bax , abolishes caspase 3 activity and reduces DNA damage . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Further studies demonstrated that the expression of Bcl 2 and Bcl 10 ( L ) decreased in both mRNA and protein levels , whereas p 53 and Bax increased after anti NS 1 treatment . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Enhanced expression of Bax itself did not inhibit the growth rate of infected cells and did not influence expression of Bcl 2 and Bcl xL . ^^^ Caspase activation and / or an imbalance in Bax and Bcl 2 / Bcl xL expression may be the reasons for the augmentation of cytotoxicity by these drugs . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Moreover , NCTD treatment also increased the phosphorylation of Bcl 2 and Bcl 10 ( L ) but did not affect the expression of Bax or Bad . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Quantitative analysis of apoptosis and the apoptosis regulatory genes Bcl 2 , Bcl xL , and Bax were performed by terminal deoxynucleotidyl transferase mediated deoxyuridine triphosphate digoxigenin nick end labeling staining and real time PCR , respectively . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Detailed tissue expression of bcl 2 , bax , bak and bcl 10 in the normal human pancreas and in chronic pancreatitis , ampullary and pancreatic ductal adenocarcinomas . ^^^ METHOD : Expression of bcl 2 , bax , bcl 10 , bak and p 53 was determined in formalin fixed paraffin wax embedded archival specimens of normal pancreatic tissue ( n = 7 ) , chronic pancreatitis ( n = 7 ) , pancreatic ductal adenocarcinoma ( n = 23 ) and ampullary cancer ( n = 7 ) by immunohistochemistry using specific antibodies . ^^^ RESULTS : In normal pancreas and chronic pancreatitis tissues , bcl 2 , bax and bcl 10 were predominantly expressed in ductal epithelial cells while p 53 was not detected . ^^^ In pancreatic ductal adenocarcinoma and ampullary cancer , bcl 2 was not detected compared with expression seen in normal acini ( p < 0 . 01 ) , minor ( p < 0 . 001 ) and major ducts ( p < 0 . 01 ) , bax expression was reduced with respect to minor ducts ( p < 0 . 01 ) but no different from normal acini or major ducts . bak and bcl 10 were more strongly expressed in malignant epithelia compared with acini and major ducts but reduced when compared with minor ducts ( p < 0 . 01 ) . ^^^ Differential survival of individual patients was predicted by the relative level of bcl 10 expression but not bax or bak , such that strong expression of bcl 10 was associated with a median postoperative survival of 171 days when compared with 912 days for diminished expression ( p < 0 . 001 ) of bcl 10 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Cells were evaluated for growth inhibition , apoptosis ( propidium iodide staining and flow cytometry , caspase 3 activation ) and for Bcl 10 ( L ) / BAX expression ( by Western blot analysis ) . ^^^ Increased cell death in PANC 1alpha was mediated by activated caspase 3 and was correlated with decreased expression of Bcl 10 ( L ) / BAX . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Peptides derived from BH 3 domains of Bcl 2 family members : a comparative analysis of inhibition of Bcl 2 , Bcl 10 ( L ) and Bax oligomerization , induction of cytochrome c release , and activation of cell death . ^^^ In vitro interaction assays were used to compare the abilities of the different peptides to inhibit Bax / Bcl 2 and Bax / Bcl 10 ( L ) heterodimerization , as well as Bcl 2 and Bax homodimerization . ^^^ Bax BH 3 peptide ( 20 amino acids ) potently inhibited both Bax / Bcl 2 and Bax / Bcl 10 ( L ) interactions , exhibiting IC ( 50 ) values of 15 and 9 . 5 microM , respectively . ^^^ The Bad BH 3 peptide ( 21 amino acids ) was slightly more potent than Bax BH 3 at inhibiting Bax / Bcl 10 ( L ) but failed to disrupt Bax / Bcl 2 . ^^^ Bcl 2 BH 3 peptide ( 20 amino acids ) was inactive toward Bax / Bcl 2 and had only a weak inhibitory effect on Bax / Bcl 10 ( L ) heterodimerization . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Using reverse transcription polymerase chain reaction , Bcl 10 ( L ) and Bcl 2 were overexpressed in Q versus P AML cells , whereas no difference in Bcl XS and Bax expression was found . ^^^ Furthermore , the Bcl 10 ( L ) / X ( S ) but not the Bcl 2 / Bax ratio was higher in Q AML compared with normal CD34+ Q cells ( P = 0 . 001 ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Department of Veterans Affairs Cooperative Study Program ( VA CSP 268 ) were evaluated for the expression of Bcl 2 , Bcl 10 ( L ) , and Bax protein expression . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In addition , CK 2 promotes nuclear factor kappa B ( NF kappa B ) mediated expression of Bcl 10 ( L ) , which sequesters tBID and curtails its ability to activate BAX . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Investigation of bax , bcl 2 , bcl 10 and p 53 gene polymorphisms in multiple sclerosis . ^^^ To analyze genetic differences in the apoptosis regulating factors bcl 2 , bax , bcl 10 and p 53 we investigated polymorphisms of these genes in 105 patients with a relapsing remitting disease course and 99 controls by PCR SSCP and direct sequencing . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
High bad and bcl xL gene expression and combined bad , bcl xL , bax and bcl 2 mRNA levels : molecular predictors for survival of stage 2 soft tissue sarcoma patients . ^^^ Samples from 82 STS patients were analyzed for mRNA expression of bad , bax , bcl xL and bcl 2 by a high throughput quantitative RT PCR approach , using validated assays based on TaqMan technology . ^^^ Considering STS patients of tumor stage 2 , multivariate Cox analysis revealed that bad mRNA values > or = 10 ( p=0 . 0039 ; RR=9 . 08 ) , bcl xL > or = 1 . 5 ( p=0 . 067 ; RR=4 . 59 ) , bax > or = 0 . 005 ( p=0 . 1 ; RR=2 . 84 ) and bcl 2 < 3 ( p=0 . 42 ; RR=1 . 7 ) were associated with a poor prognosis . ^^^ There was a 14 . 5 fold and 6 . 5 fold increase in the risk for the combinations of high bax / bcl xL mRNA ( p=0 . 018 ) and bax / bcl 2 mRNA expression ( p=0 . 017 ) , respectively . ^^^ In conclusion , high bad mRNA levels and combined values of bad / bcl xL bax / bcl xL and bax / bcl 2 appear to be independent prognostic factors at least for stage 2 STS patients . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
METHODS : Paraffin embedded archival tissue from 103 N0M0 consecutive patients with invasive bladder cancer ( 28 T 1 , 57 T 2 , 13 T 3 and 5 T 4 ) was immunostained for bcl 2 , bax , bcl XL , bcl Xs , p 53 , Ki 67 and with an anti single stranded DNA monoclonal antibody recognizing the apoptotic cells . ^^^ RESULTS : Most tumours were immunoreactive for bax ( 73 . 1 % ) and bcl XL ( 80 . 9 % ) whereas bcl 2 and bcl XS expression was comparatively less common ( 44 . 4 and 28 . 9 % , respectively ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
DEX increases the expression of anti apoptotic Bcl 2 and Bcl 10 ( L ) proteins , decreases the expression of pro apoptotic Bax and inhibits Bad translocation thereby preventing the release of cytochrome c , the activation of caspases , and cell death . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Immunohistochemistry was performed for Fas , Bcl 2 , Bax , Bcl xl , inducible nitric oxide synthase ( iNOS ) , and cyclooxygenase 2 ( COX 2 ) . ^^^ We conclude that the apoptotic balance in the transformation from IM to adenocarcinoma switches to an antiapoptotic phenotype because of increased Bcl xl expression and decreased Bax expression . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bcl XL protects BimEL induced Bax conformational change and cytochrome C release independent of interacting with Bax or BimEL . ^^^ To further understand how the BH 3 only protein activates Bax , we provide evidence here that BimEL induces Bax conformational change and apoptosis through a Bcl XL suppressible but heterodimerization independent mechanism . ^^^ Substitution of the conserved leucine residue in the BH 3 domain of BimEL for alanine ( M 1 ) inhibits the interaction of BimEL with Bcl XL but does not abolish the ability of BimEL to induce Bax conformational change and apoptosis . ^^^ Moreover , the Bcl XL mutant ( mt 1 ) , which is unable to interact with Bax and BimEL , blocks Bax conformational change and cytochrome c release induced by BimEL in intact cells and isolated mitochondria . ^^^ Taken together , these findings indicate that BimEL may activate Bax by damaging the mitochondrial membrane structure directly , in addition to its binding and antagonizing Bcl 2 / Bcl XL function . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
CD 40 ligation and TNF alpha prevented release of cytochrome c and activation of caspase 3 , which could not be explained by effects on the expression of Bcl 2 , Bcl 10 ( L ) or Bax . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
To analyze the mechanisms of the apoptotic activity of Cl F araA , we sought to determine the effects of the drug on the levels of Bcl 2 family proteins ( Bcl 2 , Bcl 10 ( L ) , Mcl 1 , Bax , Bak ) and cell survival signals via Akt . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Changes ( mRNA , protein ) in expression of major proapoptotic p 53 , p21WAF1 / CIP1 , bax , bcl Xs genes , and the antiapoptotic bcl 2 gene were observed in malignant MCF 7 and MDA MB 231 cells and in benign MCF 10a human mammary tumor cells in culture . ^^^ Apparent antiapoptotic effects of increased bcl 2 expression in MDA MBA 231 cells were countered by increased proapoptotic p21WAF1 / CIP1 , Bax , and Bcl Xs proteins . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Image cytometric bcl 2 : bax and bcl 2 : bcl 10 ratios in invasive breast carcinoma : correlation with prognosis . ^^^ Some of the members , such as bcl 2 and bcl 10 ( L ) , inhibit cell death , whereas others , such as bax and bcl 10 ( S ) , promote cell death . ^^^ We evaluated the ratios of bcl 2 : bax and bcl 2 : bcl 10 expression by image cytometry in invasive breast carcinoma to determine prognostic significance . ^^^ DESIGN : Five micron sections of formalin fixed , paraffin embedded tissue from 88 invasive breast carcinomas were immunostained using steam antigen retrieval , an avidin biotin complex technique with automated stainer and primary antibodies against bcl 2 ( 1 / 160 ; Dako , Carpenteria , CA ) , bax ( 1 / 1 , 500 ; PharMingen , San Diego , CA ) , and bcl 10 ( 1 / 1 , 500 ; PharMingen ) . ^^^ Positive controls were tonsil ( bcl 2 ) and normal breast ( bax and bcl 10 ) tissue samples . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We have investigated whether subsets of indolent B cell non Hodgkin ' s lymphoma ( IB NHL ) differ in the expression of the bcl 2 family members ; 116 cases of IB NHL , composed of chronic lymphocytic leukemia ( CLL , n = 48 ) , follicular lymphoma ( FL , n = 38 ) , marginal zone B cell lymphoma ( MZBCL , n = 15 ) , and mantle cell lymphoma ( MCL , n = 15 ) , were investigated for expression of bcl 2 , bcl 10 , mcl 1 , bax , and bak proteins by immunohistochemistry . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The antiapoptotic protein Bcl 10 ( L ) prevents the cytotoxic effect of Bax , but not Bax induced formation of reactive oxygen species , in Kluyveromyces lactis . ^^^ The antiapoptotic protein Bcl 10 ( L ) , when co expressed with Bax , localized to the mitochondria and prevented Bax cytotoxicity . ^^^ These data suggest that in K . lactis cells expressing Bax , ROS are not the sine qua non of cell death and that the antiapoptotic function of Bcl 10 ( L ) is not limited to its antioxidant property . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Total endothelial cell growth factor deprivation gave a significant increase in apoptosis accompanied by a decrease of Bcl 2 in apoptotic cells while Bcl xl and Bax levels were unaffected . ^^^ Our data indicate that anti apoptotic protein Bcl 2 and pro apoptotic protein Bax are reciprocally regulated during apoptosis , whilst Bcl xl is essentially unaffected . ^^^ This implies that Bcl 2 / Bax ratio rather than Bcl xl controls apoptosis in primary endothelial cells . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bcl xL expression detected in both mRNA and protein level assays was three times higher in DLD1 / TRAIL R cells than in parental or DLD1 / Bax R cells . ^^^ A survey of molecules involved in TRAIL or Bax mediated apoptotic pathways showed no significant change in expression of death receptors , death decoy receptors ; FLIP ; Bcl 2 ; Bcl xS ; Bax ; Bak ; XIAP or caspase 2 , 7 , 8 , or 9 in either DLD1 / Bax R or DLD1 / TRAIL R cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
This might be related to decreased Bcl xL expression and increased bax expression , which is subsequently followed by cytochrome c release and caspase activation and also by microglia mediated inflammatory responses via the NFkappaB and mitogen activated protein kinase pathways . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The immunohistochemistry assay was used to detect the protein levels of Bcl 2 , Bcl xl , Bax , inducible nitric oxide synthase ( iNOS ) , neuronal NOS ( nNOS ) , and cleaved caspase 3 . ^^^ Moreover , Rg 1 elevated the levels of cleaved caspase 3 , Bax , and iNOS , but reduced the levels of Bcl 2 and Bcl xl ( P < 0 . 01 ) . ^^^ CONCLUSION : Rg 1 has protective effect against MPTP induced apoptosis and this effect may be attributed to enhancing Bcl 2 and Bcl xl expression , reducing Bax and iNOS expression , and inhibiting activation of caspase 3 . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Cell survival indices including proliferating cell nuclear antigen ( PCNA ) , Bcl 2 , Bcl xL and Bax were measured by immunohistochemistry and Western blots . ^^^ Bcl 2 was enhanced in the HGF transfected UUO rats , while no changes of Bcl xL and Bax were found . ^^^ Bcl 2 rather than Bcl xL or Bax may contribute to the anti apoptotic function of HGF . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Pyruvate significantly increased the ratio of Bcl Xl ( antiapoptotic molecule ) / Bax ( proapoptotic molecule ) , prevented the release of cytochrome c from mitochondria , and decreased the fragmentation of caspase 3 and poly ( ADP ribose ) polymerase ( DNA repair enzyme ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
No correlation was found between apoptosis sensitivity and the expression of TNF receptor 1 or the expression of Bax , Bcl 2 and Bcl 10 ( L ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Changes of bcl 10 ( L ) and bax mRNA expression following traumatic brain injury in rats . ^^^ The bcl 10 ( L ) and bax mRNA expression was detected by reverse transcription polymerase chain reaction ( RT PCR ) . ^^^ CONCLUSIONS : Decreased expression of bcl 10 ( L ) mRNA and increased expression of bax mRNA coincides with apoptosis following brain injury . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
CD 437 mediated apoptosis was not associated with the modulation of Bcl 2 , Bax , or Mcl 1 levels , but was associated with the cleavage of the antiapoptotic protein Bcl 10 ( L ) to a proapoptotic 18 kD form . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Proapoptotic BAD ( Bcl 2 associated death protein ) has been shown to dissociate from its sequestered site with the molecular chaperone protein 14 3 3 and displace proapoptotic BAX ( Bcl 2 associated 10 protein ) from antiapoptotic BCL Xl . ^^^ In control hippocampus and cortex , BAD was found constitutively bound to 14 3 3 , whereas BCL Xl bound BAX . ^^^ Within damaged hippocampus , seizures induced the dissociation of BAD from 14 3 3 and the subsequent dimerization of BAD with BCL Xl as determined by immunoprecipitation and immunohistochemical colocalization . 14 3 3 was found to translocate to the nucleus of degenerating neurons , whereas BAX accumulated at mitochondrial membranes . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Immunohistochemical analyses of bcl 2 , bax , bcl 10 , and steroid receptors were performed in 22 endometrial carcinomas , 26 endometrial hyperplasias , and 19 cases of normal cyclical endometrium . ^^^ There was increased expression of bax , decreased expression of bcl 2 , and persistence of bcl 10 protein in advanced endometrial carcinomas . ^^^ Our findings show that ovarian hormones have a regulatory role on bcl 2 protein and that there is a correlation between other members of the bcl 2 family ( bcl 10 and bax ) and steroid hormone receptors . ^^^ Bax / bcl 10 may be the major control mechanisms of apoptosis in advanced carcinomas ; other members of the bcl 2 family may also be under hormonal control . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Although protein expression of Fas , FADD , Bax , Bak , and Bcl 10 in the whole cell lysates was not changed by H pylori , Bax was decreased from mitochondria free cytosol suggesting that Bax was translocated into mitochondria . ( 3 ) Cell death and the activities of caspases 3 and 8 were promoted in MKN 45 cells stably expressing super repressor IkappaBalpha that inhibits NFkappaB activation . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
On the other hand , Trp P 1 upregulated anti apoptotic factors Bcl 2 and Bcl XL and downregulated pro apoptotic factor Bax in mitochondria 1 hr after injection , indicating that Trp P 1 also stimulated anti apoptotic signals . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Here we show that expression of the endogenous bcl xL was strongly downregulated in NIH3T3 cells within 2 h after UV C irradiation , and that of bax was upregulated from 8 h after irradiation . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The behaviour of Bcl 2 , Bax and Bcl 10 in Darier ' s disease . ^^^ There is little information on the behaviour of Bcl 2 , Bax and Bcl 10 in DD . ^^^ OBJECTIVES : To investigate the dynamic control and the behaviour of Bax , Bcl 2 and Bcl 10 in DD . ^^^ CONCLUSIONS : The decrease or absence of Bcl 2 and Bcl 10 and the imbalance of Bax in the epithelial cells of affected DD skin is likely to be an important control point determined by the genetic mutation of SERCA 2 , which modifies the programme of the antiapoptotic proteins . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The Bcl 2 , Mcl 1 , Bcl xL / S , Bcl w , Bax , Bak , and Bad were shown to be expressed in both malignant and non neoplastic , normal plasma cells . ^^^ Furthermore , the anti apoptotic proteins Bcl 2 , Mcl 1 and Bcl xL were down regulated , while the expression of the pro apoptotic Bax protein was increased . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We also detected the expression of Bax , Bak , p 53 , Bcl 2 , Bcl 10 ( L ) , AIF and MRP 1 by Western blots . ^^^ Bcl 2 protein expression was significantly increased in p 50 , p 46 and p 33 transfected cells , while the expression of Bax , Bak , p 53 , Bcl 10 ( L ) and MRP 1 was essentially unchanged . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Hepatocellular carcinoma and markers of apoptosis ( bcl 2 , bax , bcl 10 ) : prognostic significance . ^^^ Patients with tumors expressing promoters of apoptosis ( bax ) versus inhibitors of apoptosis ( bcl 2 , bcl 10 ) may have increased survival . ^^^ Seventy HCC were immunostained for bcl 2 , bax , and bcl 10 . ^^^ Staining frequency for bcl 2 , bax , and bcl 10 was 20 % , 66 % , and 60 % , respectively . ^^^ By multivariate analysis , this relationship held for bax ( P = 0 . 011 ) and bcl 10 ( P = 0 . 048 ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
CD 44 cross linkage up regulated expression of the pro apoptotic protein Bax , and down regulated the anti apoptotic protein , Bclx ( L ) , in the presence of DEX . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We have proposed that Bax and DeltaN76Bcl 10 ( L ) ( the Bax like cleavage fragment of Bcl 10 ( L ) ) function by forming pores that are at least partially composed of lipids ( lipidic pore formation ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The present study therefore , examines the expression of active and proactive caspase 3 , and the bax , bcl 2 and bcl 10 members of the bcl 2 family , to characterise the temporal profile of apoptosis in a model of traumatic brain injury in rats that produces significant diffuse axonal injury . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
IL 1beta induced CFb apoptosis was associated with an increase in p 53 and Bax protein expression with no changes in Bcl 2 or Bcl 10 ( L ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
G ( 2 ) M arrest was associated with phosphorylation of Bcl 2 ( but not BAD , Bax , or Bcl XL ) : both of these end points were abrogated by treatment with a calcium chelator . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Survival probability depends on multiple biologic factors , including overexpression of Bcl 2 , p 53 , Bax , Bcl 10 ( L ) , MIB 1 , and apoptotic index . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The resistance of this cell subset to starvation induced programmed cell death , lasting from 48 to 96 hours , is accompanied by a rise of mitochondrial adenosine triphosphate ( ATP ) , a high nicotinamide adenine dinucleotide ( NAD ) / reduced nicotinamide adenine dinucleotide ( NADH ) ratio , and by the up regulation of expression of the antiapoptotic proteins Bcl 2 and Bcl 10 , together with an increase in the cytoplasmic , inactive , form of Bax . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We hypothesized that apoptosis is a downstream event in erectile dysfunction , and pro apoptotic ( Bak and Bax ) and anti apoptotic ( Bcl 2 and Bcl 10 ) factors are involved in the etiology of aging erectile dysfunction . ^^^ Gene expression of pro apoptotic ( Bak and Bax ) and anti apoptotic ( Bcl 2 and Bcl 10 ) factors were then analyzed by reverse transcription polymerase chain reaction . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
GCDCA ( 100 microm ) did not alter expression of TRAIL R1 / DR4 , TRAIL R2 / DR5 , procaspase 8 , cFLIP L , cFLIP s , Bax , Bcl xL , or Bax . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Antibody cellular translocation induced the increase of bcl 10 ( s ) and bax and the decrease in the bcl 10 ( L ) protein . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We conclude that mitochondrial protein release in apoptosis can be mediated by supramolecular openings in the outer mitochondrial membrane , promoted by BH3 / Bax / lipid interaction and directly inhibited by Bcl 10 ( L ) . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The levels of anti apoptotic proteins Bcl 2 and Bcl 10 ( L ) were increased , and the cellular levels of pro apoptotic proteins Bid and Bax were reduced . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Furthermore , the expression levels of procaspase 3 and the ratio of the proapoptotic protein bax to antiapoptotic protein bcl xl were several folds higher in immature than mature oligodendrocytes . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Using both an immunohistochemical and an immunoblot approach , we found that IL 1 increased the expression of Bcl 2 and decreased that of Bax , while having no effect on the expression of Bclx ( L ) , Fas and CD 40 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
To clarify the subcellular mechanisms of age associated dysregulation of apoptosis and the effects of CR , we analyzed the expression of genes promoting apoptosis ( p 53 , Fas receptor , Fas ligand , TNF receptor 1 , TNFalpha , Bax , TGF beta 1 ) and genes preventing apoptosis ( Bcl 2 and Bcl XL ) in the livers of 3 , 6 , 15 , and 24 month old male F 344 rats that were either fed ad libitum or subjected to a 30 % reduction in food intake ( CR ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The release of cytochrome c is the central gate in turning on / off apoptosis , and is regulated by the interaction of proapoptotic proteins , including Bid , Bax and Bak , and antiapoptotic proteins including Bcl 2 and Bcl 10 ( L ) , and a specific class of inhibitors of apoptosis proteins ( IAPs ) including Akt , survivin , and heat shock proteins . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Effect of bax , bcl 2 and bcl xL on regulating apoptosis in tissues of normal liver and hepatocellular carcinoma . ^^^ AIM : To investigate the expression of bax , bcl 2 and bcl xL mRNA in the tissues of normal liver and hepatocellular carcinoma ( HCC ) , and analyze the relationship between the expression of bax , bcl 2 and bcl xL mRNA and clinical parameters of HCC patients . ^^^ METHODS : The expression of bax , bcl 2 and bcl xL mRNA of normal liver and HCC was measured by Northern blot . ^^^ RESULTS : A very low mRNA level was indicated at bax , bcl 2 and bcl xL in the HCC tissues in contrast to the tissues of normal liver by Northern blot analysis . ^^^ The analyses of mRNA level revealed that HCC tissues exhibited a mean 7 . 6 fold decrease in bax , 4 . 2 fold in bcl 2 and 3 . 5 fold in bcl xL in comparison with normal control tissues , respectively . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Treating HT 1197 cells with 5 FU enhanced expression of the pro apoptotic molecule Bax , while JTE 522 treatment reduced expression of the anti apoptotic molecule Bcl XL , resulting in a significantly higher ratio of Bax to Bcl XL . ^^^ CONCLUSIONS : This study shows that combination treatment of bladder cancer cells with the selective COX 2 inhibitor JTE 522 and 5 FU results in synergistic cytotoxicity and apoptosis due to the enhanced Bax to Bcl XL expression ratio . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
A decrease in the anti apoptotic protein , Mcl 1 , was detected in emodin treated HL 60 cells , whereas other Bcl 2 family proteins including Bax , Bcl 2 , Bcl XL , and Bad remained unchanged . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Apoptosis was studied by the terminal deoxynucleotidyl transferase ( TdT ) mediated deoxy UTP nick end labeling ( TUNEL ) method , and immunohistochemistry was used to detect p 53 , caspase 3 and 6 , the antiapoptotic proteins Bcl 2 and Bcl 10 , and the proapoptotic proteins Bax and Bad . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We investigated its occurrence and time course in rat hindlimb skeletal muscles during the first 3 weeks of postnatal development , its morphological and biochemical features , and the concomitant expression of Bax , Bcl 2 , and Bcl 10 ( L ) . ^^^ Constitutive levels of Bax , Bcl 2 , and Bcl 10 ( L ) were detected by means of reverse transcriptase polymerase chain reaction ( RT PCR ) analysis at all ages examined , with a moderate increase around the period of maximal apoptosis . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
While Bcl 2 and Bax expression did not change , Bcl 10 ( L ) was down regulated and Bcl xs was up regulated after being exposed to flavopiridol . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In 30 consecutive children with ALL treated with prednisone we determined changes in the expression of Bcl 2 , Bax and Bcl xl proteins in leukemic lymphoblasts and related these to clinical features and rate of prednisone induced apoptosis . ^^^ At diagnosis , we detected expression of Bcl 2 and Bcl xl protein in 28 samples , while Bax expression protein was detected in 21 of the 30 patients . ^^^ Prednisone treatment induced a decrease in Bcl 2 and Bcl xl levels in 17 and 16 of the 28 patients , respectively , while Bax protein increased in 14 of the 21 patients . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bcl 2 members can either be anti ( Bcl 2 , Bcl 10 ( L ) , Bcl w ) or pro apoptotic ( Bax , Bak , Bid , Bad , Bcl 10 ( S ) ) . ^^^ The expression of the pro apoptotic members Bax , Bak , Bid , and Bcl 10 ( S ) was significantly ( P < 0 . 05 ) decreased after TPN . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The expression of anti apoptotic proteins ( Bcl 2 , Bcl 10 ( L ) ) and pro apoptotic proteins ( Bax , Bcl 10 ( S ) , Bad , and Bak ) in response to cryo injury varied in this cell line panel . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Pro death Bax increased , whereas anti death Bcl 2 and Bcl XL decreased , and apoptotic TUNEL positive cells were detected in the hippocampus of klotho mutant mice at the age of 7 wk . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Using cultured prostate cancer ( PC ) cell lines , LN CaP and ALVA 31 , we studied the effects of 1alpha , 25 ( OH ) 2 Vitamin D 3 ( VD 3 ) on expression of several apoptosis regulating proteins including : ( a ) Bcl 2 family proteins ( Bcl 2 , Bcl 10 ( L ) , Mcl 1 , Bax , and Bak ) ; ( b ) the heat shock protein 70 binding protein BAG1L ; and ( c ) IAP family proteins ( XIAP , cIAP 1 , and cIAP 2 ) . ^^^ VD 3 induced decreases in levels of antiapoptotic proteins Bcl 2 , Bcl 10 ( L ) , and Mcl 1 , BAG1L , XIAP , cIAP 1 , and cIAP 2 ( without altering proapoptotic Bax and Bak ) in association with increases in apoptosis . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Apoptosis , assayed by terminal deoxynucleotidyl transferase mediated dUTP nick end labeling ( TUNEL ) , expression of activated caspase 3 , and proapoptotic genes Bax and Bcl 10 ( L ) , was not detected until acute vascular rejection was well advanced , and even then , apoptosis was largely confined to myocytes . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
From this we could exclude the involvement of the anti apoptotic protein Bcl 10 ( L ) as well as its pro apoptotic counterpart Bax , since they are not expressed . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The tBax ( 29 ) induced apoptotic cell death was substantially resistant to Bcl 10 ( L ) mediated rescue , compared with wt Bax , in spite of the complex formation between these two molecules . ^^^ Together , the tBax ( 29 ) would be valuable for the treatment of tumors with high levels of Bcl 10 ( L ) as well as the understanding of Bax mediated apoptotic processes . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Doxorubicin did not affect steady state levels of Bax , Bcl 2 and Bcl 10 ( L ) in the majority of the prostate cancer cell lines . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The release of cytochrome c can be influenced by different Bcl 2 family member proteins , including Bax , Bid , Bcl 2 , and Bcl 10 ( L ) . ^^^ Bax and Bid potentiate cytochrome c release , whereas Bcl 2 and Bcl 10 ( L ) antagonize this event . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
DES induced the expression of 12 genes ( bad , bax , bcl 10 , caspase 1 , p 53 , cyclin D 3 , GADD 45 , p 21 , p 15 , p 27 , p 57 and Skp 1 ) and down regulated the expression of eight genes ( bcl 2 , caspase 2 , caspase 7 , caspase 8 , E 124 , iNOS , mdm 2 and NFkappab 1 ) at twofold or greater levels . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In MB 468 cells with overexpression of Bcl 2 ( 468 / Bcl 2 ) , FP induced Bax conformational change and apoptosis were inhibited , whereas the FP mediated decline in the levels of IAP proteins , Mcl 11 and Bcl 10 ( L ) remained unaltered . ^^^ Treatment with Epo B followed by FP induced more Bax conformational change and was associated with a greater decline in the levels of XIAP , cIAP 2 , Mcl 1 , and Bcl 10 ( L ) . ^^^ Taken together , these findings suggest that the superior sequence dependent anti breast cancer activity of Epo B followed by FP may be due to FP induced Bax conformational change and down regulation of the antiapoptotic IAP , Bcl 10 ( L ) , and Mcl 1 proteins , but this treatment may not overcome the resistance to apoptosis of breast cancer cells conferred by overexpression of Bcl 2 . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Whereas IL 4 and PPARgamma ligands failed to induce cleavage of Bid and release of cytochrome c from mitochondria , they caused translocation of the proapoptotic protein Bax from cytoplasm to mitochondria with a concomitant decrease in the Bcl 10 ( L ) level . ^^^ We therefore believe that in unstimulated cells Bcl 10 ( L ) and Bax form a heterodimer , in which Bcl 10 ( L ) dominates and prevents the induction of apoptosis , whereas in IL 4 stimulated cells the 15 ( S ) HETE / PPARgamma complex down regulates Bcl 10 ( L ) , and the resulting overweight of Bax commits the cell to apoptosis via caspase 3 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
METHODS : The expression of apoptosis associated proteins ( bcl 2 , bcl xL , bax , bcl xs ) , the activity of caspase 3 and cleavage of poly ADP ribose polymerase ( PARP ) were determined with Western blot analysis in the cisplatin resistant cell ( COC1 / DDP ) and cisplatin sensitive human ovarian cancer cell ( COC 1 ) . ^^^ RESULTS : The expression of bcl 2 and bcl XL in COC1 / DDP cell was significantly higher than that in COC 1 cell , whereas the expression of bax showed no change in COC1 / DDP and COC 1 . ^^^ CONCLUSIONS : Cisplatin resistance in human ovarian cancer cell lines may associated with the overexpression of anti apoptotic protein bcl 2 and downregulation of caspase 3 activity , but not associated with the expression of bax and bcl xs . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
METHODS : Flow cytometry and a panel of antibodies were used to analyze the expression of MDR proteins ( P gp , MRP , LRP , BCRP , GST pi ) and apoptosis modulating proteins ( bcl 2 , bcl 10 , bax , bad ) in MDR cell line HL 60 / VCR and drug sensitive cell line HL 60 . ^^^ The levels of apoptosis modulating proteins ( bcl 2 , bcl 10 , bad ) were ( 2 . 48 , 1 . 25 , 1 . 08 fold ) higher in HL 60 / VCR than in HL 60 , while the pro apoptosis protein bax contrarily decreased in HL 60 / VCR . ^^^ CONCLUSION : Various MDR mechanisms were involved in multi drug resistance HL 60 / VCR cell line , which including increasing expression of drug resistance protein ( P gp , MRP , BCRP , and GST pi ) ; the apoptosis modulating proteins ( bcl 2 , bcl 10 , bax , and bad ) might take part in the mechanism of drug resistance . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Electrophoresis and Western blotting were used to analyze DNA fragmentation and expression of DNA fragmentation factor ( DFF 45 ) , Bcl 2 , Bcl xL and Bax genes respectively . ^^^ The anti apoptotic genes Bcl 2 and Bcl xL were down regulated and the pro apoptotic gene Bax was expressed at higher levels compared with the euthyroid state . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Treatment with G 3139 led to a sequence specific reduction of Bcl 2 protein levels within 4 days of exposure in 10 out of 11 clinical samples from patients with chemosensitive and multidrug resistant disease , without significant reduction of alpha Actin , Bax , Bcl XL , or Mcl 1 proteins . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We detected apoptosis with the in situ terminal deoxynucleotidyl transferase assay and flow cytometry , and measured the expression of several apoptotic regulatory proteins ( Bcl 2 , Bax , Bclx , NF kappa B ) with Western blotting . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Apo2L / TRAIL induced the expression of pro apoptotic proteins , Bad and Bax ; downregulated the anti apoptotic proteins , Bcl 2 and Bcl xL ; and activated caspases 3 , 7 , 8 , 9 and 10 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
This increased apoptosis was accompanied by decreased antiapoptotic bcl 2 mRNA expression among bcl 2 related genes ( bcl 2 , bax , bak , mcl 1 , and bcl 10 ( L / S ) ) , and the effect was also more prominent in the cagA ( + ) strains . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bcl xL overexpression blocks bax mediated mitochondrial contact site formation and apoptosis in rod photoreceptors of lead exposed mice . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Nonetheless , there were no significant alterations in the level of Bcl 2 , Bcl 10 ( L ) , Bax and Bak by the proteasome inhibitor , nor any evidence of cytochrome ( cyt ) c release into cytosol from dying cells , suggesting that cyt c is not involved . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Alteration of the expression of Bcl 2 , Bcl 10 , Bax , Fas , and Fas ligand in the involved skin of psoriasis vulgaris following topical anthralin therapy . ^^^ In normal skin , keratinocytes expressed low to absent levels of Bcl 10 and Bax , while Bcl 2 was detected only in melanocytes in basal layers . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Fifty excisional biopsy samples were studied by immunohistochemical technique for the differential expressions of bcl 2 , bax , bcl 10 and alpha smooth muscle actin . ^^^ Bcl 2 , bcl 10 and bax were expressed in 34 ( 68 % ) , 38 ( 76 % ) and 41 ( 82 % ) specimens , respectively . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
EXPERIMENTAL DESIGN : We investigated proteins involved in regulation of apoptosis ( p 53 , BAX , BCL 2 , and BCL 10 ( L ) ) , cell cycle control [ p 21 and retinoblastoma protein ( RB ) ] , and drug export and inactivation [ P glycoprotein , multidrug resistance associated protein ( MRP ) 1 , MRP 2 , breast cancer resistance protein , lung resistance protein , metallothionein , and glutathione S transferase pi ] immunohistochemically in samples of unselected GCT patients ( n = 20 ) , patients with advanced metastatic disease in continuous remission after first line chemotherapy ( n = 12 ) , and chemotherapy refractory patients ( n = 24 ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Phytosphingosine induced mitochondrial translocation of Bax from the cytosol without changes in the protein levels of Bcl 2 , Bcl xL , and Bax . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The expression of apoptosis related genes BCL 2 , BAX , BCL2L1 , BCL2A1 , MCL 1 , DAPK 1 and MYC was studied by quantitative real time polymerase chain reaction on total RNA samples from patients with acute lymphoblastic leukaemia ( ALL , n = 16 ) , acute myeloid leukaemia ( AML , n = 27 ) , chronic myeloid leukaemia ( CML , n = 12 ) , mantle cell lymphoma ( MCL , n = 19 ) and chronic lymphoid leukaemia ( CLL , n = 32 ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bcl 2 , bax and bcl 10 protein expression were detected by standard avidin biotin peroxidase method . ^^^ Bcl 2 , bax and bcl 10 expression were detected in 84 % , 80 % , and 76 % , respectively , of normal squamous mucosa . ^^^ Pre therapeutic bcl 2 , bax and bcl 10 protein expression ( 27 % , 75 % , and 87 . 5 % , respectively ) were not associated with tumor response or resistance to therapy . ^^^ Preoperative chemoradiotherapy induces expression of bax and bcl 10 protein . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In this model of simulated ischemia , represented by serum deprivation plus hypoxia , cardiomyoblasts apoptosis was associated with a p 53 independent Bax accumulation and with a down regulation of Bcl xL , whereas the levels of cIAP 1 , cIAP 2 and 10 IAP proteins did not change . ^^^ Phorbol 12 myristate 13 acetate significantly reduced the induction of apoptosis , inhibiting caspase 3 cleavage , Bax accumulation , Bcl xL down regulation as well as restoring cell viability . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Sequential analyses were made following ethanol exposure on these two postnatal days , with assessments of NTFs nerve growth factor ( NGF ) , brain derived neurotrophic factor ( BDNF ) , neurotrophin 3 ( NT 3 ) , and neurotrophin 4 ( NT 4 ) ; apoptosis related proteins Bcl 2 , Bcl xl , Bax , Akt and c jun N terminal kinase ( JNK ) ; antioxidants superoxide dismutase , glutathione reductase and catalase ; and ROS . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The effect of IFN a is not accompanied by a modulation of CD 95 , CD95L , p 53 , p 21 ( WAF 1 ) , p 27 , bcl 2 , bcl xL , bax , NFkappaB , or IkappaB gene expression . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Mouse uterine epithelial apoptosis is associated with expression of mitochondrial voltage dependent anion channels , release of cytochrome C from mitochondria , and the ratio of Bax to Bcl 2 or Bcl 10 . ^^^ In addition , the apoptotic index showed good correlation with the release of cytochrome c from mitochondria , activation of caspase 3 , which was immunohistochemically detected only in the epithelium , and the mRNA and protein ratios of Bax : Bcl 2 and Bax : Bcl 10 in the uterus . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We report herein that human oocytes and preimplantation embryos possess abundant levels of transcripts encoding cell death suppressors , Mcl 1 , Bcl 10 and Bag 1 , and the cell death inducer genes , Bax and Caspase 2 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Both antioxidant vitamins attenuated the increase in Bax pro apoptotic protein and augmented Bcl xL antiapoptotic protein levels ( 35 % ) at 3 and 5 hr post PH ; Bcl xL / Bax ratio was , therefore , increased . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Adenoviral transfer of mda 7 leads to BAX up regulation and apoptosis in mesothelioma cells , and is abrogated by over expression of BCL XL . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
CD 53 stimulated cells also have an increase in the level of bcl 10 ( L ) and a reduction of bax protein , two components of the mitochondrial apoptotic pathway , changing their ratio by 24 fold in the direction of survival . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The expression of Bcl 2 family proteins ( Bcl 2 , Bax and Bcl 10 ( L ) ) was analyzed by flow cytometry showing high expression of the three proteins which was not significantly modified after treatment with either PSC 833 or CsA on the sensitive as well as on the resistant cell lines . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Regulation of 17 AAG induced apoptosis : role of Bcl 2 , Bcl XL , and Bax downstream of 17 AAG mediated down regulation of Akt , Raf 1 , and Src kinases . 17 allylamino demethoxy geldanamycin ( 17 AAG ) inhibits the chaperone function of heat shock protein 90 ( Hsp 90 ) and promotes the proteasomal degradation of its misfolded client proteins . ^^^ In addition , in HL 60 / Bcl 2 and HL 60 / Bcl xL cells , which ectopically express Bcl 2 and Bcl xL respectively , 17 AAG induced Bax conformational change , cytosolic accumulation of cyt c and Smac / DIABLO , and apoptosis were markedly inhibited . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
High toxic concentration of DA ( 500 microM ) , R APO ( 50 microM ) , melatonin ( 50 microM ) , and EGCG ( 50 microM ) exhibited a similar profile of proapoptotic gene expression , increasing the level of bax , caspase 6 , fas ligand , and the cell cycle inhibitor gadd 45 genes , while decreasing antiapoptotic bcl 2 and bcl xL . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Endothelial cells incubated with IL 8 had higher levels of Bcl 10 ( L ) : Bcl 10 ( S ) and Bcl 2 : Bax ratios . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Precursors from aged animals were deficient in ability to modulate expression of apoptosis regulatory genes Bax , Bcl 2 , and Bcl 10 in comparison to B cell precursors from young animals . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
METHODS : Immunohistochemical analysis of Bax , Bcl 2 , and Bcl 10 ( L ) was performed in tissue specimens of patients with RA and compared to normal synovial tissue . ^^^ Bax and Bcl 10 ( L ) were markedly colocalized in synovium . ^^^ CONCLUSIONS : The marked colocalization of Bax and antiapoptotic Bcl 10 ( L ) as well as the low frequency of TUNEL positive cells in RA synovium suggest that Bax activity is not sufficient to decrease synovial hyperplasia in RA . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Screening potential mediators of DN IkappaB and TNF induced apoptosis shows that caspase 3 , caspase 9 , poly ( ADP ribose ) polymerase , and Bax are activated , whereas levels of Bcl XL , cIAP 1 , and TRAF 6 were reduced . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
This peptide nevertheless interferes with Bax / Bcl xL interactions in vitro and stimulates the apoptotic activity of Bax when combined with Bcl xL . ^^^ Similarly , a peptide derived from the BH 3 domain of Bad stimulates Bax activity only in the presence of Bcl xL . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
These two mutants still retained the ability to interact with wild type Bcl 2 and Bcl xL , and abrogated the inhibitory effect of wild type Bcl 2 or Bcl xL on Bax or Bak induced apoptosis . ^^^ Taken together , our results demonstrate that Bcl 2 / DeltaBH1 or Bcl 2 / G145A acts as a dominant negative of endogenous anti apoptotic proteins such as Bcl 2 and Bcl xL , thereby enhancing antitumor drug induced apoptosis , and that this dominant negative activity requires both a failure of interaction with Bax and Bak through the BH 1 domain of Bcl 2 and retention of the ability to interact with Bcl 2 and Bcl xL . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
MPP ( + ) increased levels of Bax , Bcl 2 and Bcl 10 ( L ) proteins approximately 2 fold over 24 hr , with Bax increases occurring first ; Bax did not increase in rho ( 0 ) cells . ^^^ The Bax increase , but not that of Bcl 2 or Bcl 10 ( L ) , was dependent on nitric oxide ( NO ) and seemed post transcriptional . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The long term NO generator diethylenetriamine NO ( DETA NO ) reproduced the post transcriptional Bax protein increase , but did not increase Bcl 2 or Bcl 10 ( L ) proteins . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
This report suggests enhanced apoptosis of blood neutrophils during the acute phase of CA resulting from enhanced expression of the pro apoptotic proteins Bax and Bik and from a decrease of the anti apoptotic BCl 10 ( L ) mRNA . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The cytosolic domain of BCL w consists of 8 alpha helices , which adopt a fold similar to that of BCL xL , BCL 2 , and BAX proteins . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
This review focuses on novel strategies to induce apoptosis in glioma cells by transduction with adenoviral vectors carrying a variety of apoptosis related genes , including Fas ligand , Fas , FADD , caspase 8 , p 53 , p33ING1 , p73alpha , Bax , Apaf 1 , caspase 9 , IkappaBdN , caspase 3 , Bcl 2 , and Bcl 10 ( L ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The paraquat mediated gene or protein expression of proapoptotic Bax , Bcl w , and Bcl 10 ( S ) , cell survival / death factors GADD 45 , MDM 2 , c Myc , and caspase 3 was upregulated , but that of antiapoptotic Bcl 2 was downregulated in the GPX 1 / mice vs . the WT mice . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Molecular markers of outcome after radiotherapy in patients with prostate carcinoma : Ki 67 , bcl 2 , bax , and bcl 10 . ^^^ The current study examined the association between expression levels of Ki 67 , bcl 2 , bax , and bcl 10 in pretreatment biopsy specimens and patient outcome after definitive radiotherapy alone . ^^^ Expression levels of Ki 67 ( MIB 1 staining ; n = 106 patients ) , bcl 2 ( n = 77 patients ) , bax ( n = 70 patients ) , and bcl 10 ( both long and short splice variants ; n = 72 patients ) were determined by immunohistochemical staining . ^^^ RESULTS : High Ki 67 LI ( > 3 . 5 % ) expression was observed in 33 % of patients , overexpression of bcl 2 was observed in 16 % of patients , altered bax expression was observed in 23 % of patients , and altered bcl 10 expression was observed in 53 % of patients . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Whether conventional hypothermic CPB induces myocyte apoptosis in dog hearts and modulation of bcl 2 , bcl xl , bax , bad , and caspase 3 pathways in this setting was investigated . ^^^ Immunohistochemistry and flow cytometry were employed for detection of expressions of bcl 2 , bcl xl , bax and bad proteins . ^^^ The results of immunohistochemistry demonstrated that bcl 2 , bcl xl , bax and bad proteins were constitutionally present on the sarcolemma of the LV myocytes . ^^^ FACS results showed that , after CPB , expressions of bax and bad in CPB group were significantly upregulated , while the expressions of bcl 2 and bcl xl were not significantly changed in both groups . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Quantitative measurements of apoptosis , Bax and Bcl xL protein expression in the ApcMin mice revealed the ratio of Bax / Bcl xL expression and apoptosis increased in the small intestine but decreased in the cecum , consistent with the regional tumorigenesis observed after sulindac . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
To dissect apoptotic genes governing the survival of colorectal carcinoma cells , we employed RNAi to silence Bcl 2 and Bcl 10 ( L ) in isogenic clones of p53+ / + and p 53 / cells , and of Bax+ / and Bax / cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
To examine p 75 ( NTR ) dependent apoptosis in tumor cells , we demonstrated that a dose dependent increase in p 75 ( NTR ) expression was associated with a concomitant increase in the mitochondrial proapoptotic effector proteins Bad , Bax and Bik and a decrease in the mitochondrial prosurvival effector proteins phospho Bad , Bcl 2 and Bcl 10 ( L ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We therefore developed a four color flow cytometry method that enables establishment of apoptosis related protein expression such as Bcl 2 , Bcl 10 ( L ) , Mcl 1 and Bax at diagnosis and in MRD . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
L PGDS ( 50 microg / ml ) was able to significantly inhibit VSMC proliferation and DNA synthesis and induce the apoptotic genes bax , bcl 10 , and ei 24 in SHR but had no effect on WKY cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Immunohistochemistry was used on paraffin sections to detect LMP 1 / EBV , CD 15 and the apoptosis related proteins ( bcl 2 , bax , bcl 10 , mcl 1 and CD 95 ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Our results revealed that the expression of bcl 2 and bcl 10 ( L ) decreased after 5 and 3 h p . i . , respectively ; while bax and procaspase 3 expression increased with respect to control as a function of p . i . times and at 7 h p . i . they were not observed . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We observed downregulation of the expression of inhibitors of apoptosis proteins ( IAPs ) Bcl 2 , Bcl 10 ( L ) , and survivin and upregulation of pro apoptotic p 53 and Bax as assessed by Western blotting . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
METHODS : Assessments were made of neurotrophic factors nerve growth factor , brain derived neurotrophic factor , neurotrophin 3 , and neurotrophin 4 ; apoptosis related proteins Bcl 2 , Bcl xl , Bax , Bcl xs , Bad , phosphorylated Bad , phosphorylated Akt , and phosphorylated c Jun N terminal kinase ; and the antioxidants superoxide dismutase , glutathione reductase , and catalase . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Since Bcl 2 family proteins are key regulators of apoptosis , we examined the effects of H2O2 on the expression of principal Bcl 2 family proteins ( Bcl 2 , Bcl xL , Bax , Bad ) in neonatal rat cardiac myocytes . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We previously reported that the leukemic cell death induced by an N terminally truncated Bax ( deltaN Bax : corresponding to amino acid 112 192 of full length Bax ) was not blocked by Bcl 2 or Bcl 10 ( L ) owing to the lack of the BH 3 domain needed to interact with the antiapoptotic Bcl 2 family molecules . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bcl 2 expression is markedly increased in TGF beta 1 treated pre B cells , whereas cellular FLICE like inhibitory protein long ( c FLIPL ) , Bcl XL , Bax , and Bad expression remains unchanged . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We examined the impact of beta AR blockade with metoprolol on myocardial remodeling , apoptosis , pro apoptotic ( Fas , Fas ligand , Bax , and Bcl 10 ( S ) ) and anti apoptotic ( Bcl 10 ( L ) and Bcl 2 ) gene expression , and Bcl 10 ( L ) and Bcl 10 ( S ) protein in post infarction HF in rats . ^^^ Metoprolol treatment resulted in : ( 1 ) improved LV remodeling ( P < 0 . 025 ) , ( 2 ) reduced myocardial apoptosis ( P < 0 . 005 ) , and ( 3 ) selective reduction in myocardial Bcl 10 ( S ) expression ( P < 0 . 001 ) without change in Fas , Fas ligand , Bax , Bcl 2 , or Bcl 10 ( L ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The expression of p 53 , p 21 , Bcl 2 , Bax , Bcl xL , and Bcl xS in the 22 HCC cases detected by western bioting was quantified with a densitometer . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
RESULTS : We show that CD34+ AML fractions are more resistant to apoptosis than are corresponding CD 34 AML fractions , and that this is paralleled by higher Bcl 2 , Bcl xL , Mcl 1 , Pgp and lower Bax expression levels . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Hypoxia induced cell cycle arrest at the G0 / G1 phases and massive cell apoptosis after 24 hours through a reduction in the Bcl 2 to Bax ratio , downregulation of Bcl XL and Mcl 1 , and upregulation of caspase 3 and caspase 8 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Additionally , the proteins of the p 53 regulated genes , p 21 ( WAF 1 ) and Bax , were increased with a similar time , while Bcl 2 and Bcl 10 ( L ) expression was lowered . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The present study investigated expression levels of the anti apoptotic proteins BCL 2 , BCL XL and MCL 1 and the pro apoptotic proteins BAX and BCL XS in a series of 112 peripheral T cell lymphomas ( PTCLs ) classified according to the WHO classification . ^^^ Using immunohistochemical methods and a 10 % cut off , each protein was detected in a subset of PTCLs : BCL 2 in 46 % , BCL XS in 49 % , BAX in 57 % , BCL XL in 57 % , and MCL 1 in 65 % . ^^^ The proliferation index , assessed by the MIB 1 antibody , correlated with expression levels of MCL 1 ( R = 0 . 42 , p = 0 . 003 ) , BCL 2 ( R = 0 . 32 , p = 0 . 027 ) , BAX ( R = 0 . 33 , p = 0 . 014 ) , and BCL XL ( R = 0 . 34 , p = 0 . 015 ) ( Spearman rank ) . ^^^ The mean percentage of BAX positive and BCL XS positive tumour cells was higher in ALK positive ALCL than in ALK negative ALCL or other types of PTCL ( p = 0 . 06 and p = 0 . 01 , respectively , Kruskal Wallis test ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The Bcl 10 , Mcl 1 , Bad , and Bax proteins were also expressed in all CTCL skin lesions tested . ^^^ This study examined cutaneous T cell lymphoma ( CTCL ) cell lines and cutaneous lesions for the presence of Bcl 2 gene family members and found that the two apoptosis inhibiting members Bcl xL and Mcl 1 and the two apoptosis supporting members Bad and Bax were expressed . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The objective was to evaluate the immunohistochemical expression of p 53 , p 21 , bax , bak , fas , bcl 2 and bcl 10 proteins in 10 endometriomas , 20 benign ovarian tumours ( 10 mucinous , 10 serous ) and 30 malignant ovarian tumours ( 9 mucinous , 19 serous ; 2 endometrioids ) . p 53 positive cells ( mean+ / SD ) in endometriomas , and benign and malignant tumours were 1 . 9+ / 3 . 2 , 0 and 16 . 2+ / 33 . 0 , respectively . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
It was revealed that LIGHT treatment resulted in down regulation of anti apoptosis Bcl 2 family member : Bcl 2 , Bcl 10 ( L ) , Bag 1 , and Mcl 1 ; up regulation of pro apoptosis Bcl 2 family member : Bak and Ser ( 112 ) phosphor Bad ; down regulation of pro apoptosis Bcl 2 member Bax ; the other pro apoptosis member Bid remains unaltered . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Here we reported the biochemical evidence that both pro apoptotic Bax and anti apoptotic Bcl 10 ( L ) might simultaneously contact the putative loop regions of human VDAC 1 , and the existence of VDAC 1 Bax Bcl 10 ( L ) tertiary complex in vitro suggested that VDAC 1 channel conformation and mitochondrial permeability could be determined by the delicate balance between Bax and Bcl 10 ( L ) . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Myocardial caspase 3 activation was analyzed by Western blot and the expressions of Bcl xL and Bax proteins were detected immunohistochemically . ^^^ In the immunohistochemical study , Bax and Bcl xL were expressed in myocytes , and ischemia reperfusion abolished both proteins in the center region of ischemia . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Using this system , we have focused on the action of the anti apoptotic family member Bcl 10 ( L ) , and have defined the quantitative relationships that underlie the antagonistic action of this protein on the lethal consequences of expression of the pro apoptotic family member Bax . ^^^ Bcl 10 ( L ) is able to inhibit the stable integration of Bax into mitochondrial membranes , as well as hinder the action of Bax that does become stably integrated into these membranes . ^^^ Taken together , our results suggest that both the functional and biochemical actions of Bcl 10 ( L ) may be based on the ability of this molecule to disrupt the interaction of Bax with a resident mitochondrial target that is required for Bax action . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Constitutive expression of Bcl 10 ( L ) was high in cortical tissue and astrocytes , whereas Bax expression was low . ^^^ However , Bax was highly expressed in brainstem tissue and astrocytes and Bcl 10 ( L ) expression was markedly lower . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Overexpression of anti apoptotic members of the Bcl 2 family such as Bcl 2 and Bcl XL has been implicated in cancer chemoresistance , whereas high levels of pro apoptotic proteins such as Bax promote apoptosis and sensitize tumor cells to various anticancer therapies . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Simvastatin appears to alter the balance between cell life and death promoting genes , as reflected by the decreased Bcl xL / Bax ratio . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We further report that I3C upregulates Bax / Bcl 2 ratio and downregulates Bcl xL expression in CA1a cells but not in MCF10A cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Different expression patterns of Bcl 2 , Bcl xl , and Bax proteins after sublethal forebrain ischemia in C57Black / Crj6 mouse striatum . ^^^ Although changes in the expression of apoptosis related proteins ( Bcl 2 , Bcl xl , and Bax ) have been considered to be crucially important in ischemic injury , the roles these proteins play in ischemic preconditioning induced by sublethal forebrain ischemia have not been elucidated . ^^^ Therefore , we investigated the transcription and expression of Bcl 2 , Bcl xl , and Bax in striatum of mice subjected to sublethal forebrain ischemia and lethal ischemia , with or without ischemic preconditioning . ^^^ CONCLUSIONS : Upregulation of Bcl 2 and Bcl xl but not Bax may have a role in protective ischemic preconditioning . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The expressions of Fas and Bcl 2 family genes ( Bax , Bcl 2 , Bcl xL , Bcl xS ) were not affected by NS 398 treatment in all three cell lines . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We also analyzed the relationship between TCF 4 gene splicing isoforms , proliferation ( proliferating cell nuclear antigen labeling index ) , and apoptosis [ antiapoptotic factors ( Bcl 2 and Bcl 10 ( L ) ) , proapoptotic factors ( Bak and Bax ) , and caspase 3 ] in RCC samples . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
PURPOSE : We hypothesized that apoptosis is a downstream event in erectile dysfunction , and pro apoptotic ( Bak and Bax ) and anti apoptotic ( Bcl 2 and Bcl 10 ) factors are involved in the etiology of diabetes induced erectile dysfunction . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We also attempted to estimate the level of apoptosis induced in cord blood mononuclear and CD34+ cells by employing different assays : 1 ) Annexin 5 staining using flow cytometry ( FACSCalibur ) ; 2 ) terminal deoxynucleotidyltransferase dUTP nick end labeling ( TUNEL ) ; 3 ) analysis of Bax and Bcl 10 ( L ) gene expression by RT PCR . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
At day 7 , in controls , vascular injury upregulated antiapoptotic mediator Mcl 1 and Bcl xL expression by 8 fold to 5 fold , respectively , versus sham , whereas proapoptotic Bax slightly increased by 1 . 5 fold versus sham . ^^^ AxCAdnSTAT 3 reversed the upregulated Mcl 1 and Bcl xL levels by 70 % and 37 % , respectively , while having no affect on Bax expression . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The various effects of insulin were unravelled by supplementing the in vitro culture medium with insulin ( 1 . 7 micromol l ( 1 ) ) and ( 1 ) the rates of cleavage and blastocyst development were recorded ; ( 2 ) mitogenic activity was studied by determining the total number of blastocyst cells and the ratio between trophectoderm and inner cell mass ( ICM ) cells ; ( 3 ) the frequency of apoptosis in blastocysts was determined by the TdT mediated duTP nick end labelling ( TUNEL ) assay and by quantification of the relative amounts of mRNA for Bax and Bcl XL ; and ( 4 ) expression for Glut 1 , Glut 3 and Glut 8 transcripts was compared between embryos cultured in the presence or absence of insulin . ^^^ No effects of insulin on the mRNA expression of Glut isoforms and Bax and Bcl XL were found . ^^^ These results demonstrate that the mitogenic and anti apoptotic effects of insulin on bovine preimplantation embryos did not correlate with changes in the amounts of mRNA for the glucose transporter isoforms Glut 1 , 3 and 8 , or transcripts for Bax and Bcl XL . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In both cases , Bcl 2 expression was consistently down regulated , whereas levels of other members of the Bcl 2 family , such as Bax and Bcl 10 , did not change in paclitaxel resistant cell lines . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
METHODS : The expressions of apoptosis associated genes ( bcl 2 , bax , bcl 10 ( L ) and bcl 10 ( S ) ) and the activity of caspase 3 were studied by reverse transcription polymerase chain reaction ( RT PCR ) and western blot in the cisplatin resistant ( A2780 / DDP , COC1 / DDP ) and sensitive human ovarian cancer cells ( A 2780 and COC 1 ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
However , GO 13 significantly induced a down regulation of Bcl 10 ( L ) expression in a short term treatment ( less than 3hr ) , whereas stimulated up regulation of Bax expression in a long term treatment ( 24hr ) indicating their involvement in GO 13 action . ^^^ It induced the early phase apoptosis in A 549 cells via the Bcl 10 ( L ) down regulation , and that of the late phase through up regulation of Bax expression as well as inhibition of Akt / PKB activation . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Induction of apoptosis by hydroxydibenzoylmethane through coordinative modulation of cyclin D 3 , Bcl 10 ( L ) , and Bax , release of cytochrome c , and sequential activation of caspases in human colorectal carcinoma cells . ^^^ Here , we found that HDB induced apoptotic cell death was accompanied by upregulation of cyclin D 3 , Bax , and p 21 and down regulation of Bcl 10 ( L ) , while HDB had no effect on the levels of Bcl 2 and Bad protein . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The protein contents of cytochrome c , procaspase 3 , caspase 3 , Bcl 10 ( L ) , and Bax were analyzed by Western blot and quantified by densitometry . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In these conditions , microscopic analysis revealed chromatin condensation in dying cells and the Bcl 2 , Bcl 10 ( L ) / Bax mRNA balance was altered . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Remarkably , these events occurred in the absence of any reduction in the expression of the Bcl 2 family members Bcl 2 , Mcl 1 , and Bcl xL or any change in the proapoptotic molecules Bad or Bax . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
EXPERIMENTAL DESIGN : Using wild type HCT 116 , p 53 null , Bax null , or p21 / WAF1 null isogenic derivatives , we measured expression of regulators of cellular response , and associated growth arrests or apoptosis , after SN 38 treatment , with or without antisense mediated Bcl xl knockdown . ^^^ SN 38 induced p 53 , Bax , Bcl xl , and p 53 dependent p21 / WAF1 protein accumulation . ^^^ The Bax : Bcl xl ratio changed little . ^^^ In wild type HCT 116 , but not in Bax null cells , Bcl xl knockdown induced a shift in response from drug induced senescence to apoptosis , and enhanced the global cytotoxicity of SN 38 . ^^^ The growth arrest suppresses a p 53 independent apoptotic pathway , whereas Bcl xl induction suppresses a p 53 and Bax dependent apoptotic pathway . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
It was reported that SCF / c kit , Bcl 2 and Bcl xl inhibited the apoptosis while caspase 3 , Fas , Bax and clusterine stimulated it . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
RESULTS : Ribonuclease protection assay data indicate an age related increase in Bax , Bcl xL , and procaspase 3 messenger RNA expression in aged compared with young rats . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
A decrease in the anti apoptotic protein , Mcl 1 , was detected in QUE treated HL 60 cells , whereas other Bcl 2 family proteins including Bax , Bcl 2 , Bcl XL , and Bag remained unchanged . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
AIMS : To correlate the expression of a series of apoptotic and oncogene markers ( including p 53 , Bcl 2 , BAX , Bcl XL , p21WAF , 1 / CIP1 , cyclin D 1 , HER 2 / neu ) in thymic epithelial tumours with histological type , stage and resectability and to determine whether the information on HER 2 / neu would be valuable in identifying patients who are eligible for anti HER 2 / neu treatment . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
There was no difference found in the expression of proapoptotic ( Bax and Bcl 10 ( s ) ) or antiapoptotic ( Bcl 2 and Bcl 10 ( L ) ) genes nor in the expression of the tumor suppressor gene p 53 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The analysis of the bcl 2 family of proteins demonstrates that bcl 2 , bax and bcl XL are involved in triggering apoptosis in spheroids exposed to 5 Gy . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The levels of B cell leukaemia / lymphoma 2 ( Bcl 2 ) , but not those of Bcl 2 associated 10 protein ( Bax ) or Bcl 10 ( L ) , were down regulated concentration dependently by magnolol . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
To further understand such merosin driven survival signaling , we analyzed the expression of five Bcl 2 homologs ( Bcl 2 , Bcl 10 ( L ) , Bax , Bak , Bad ) and one non homologous associated molecule ( Bag 1 ) in normal and merosin deficient myotubes , with or without pharmacological inhibitors for Fyn and p 38 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
LPS stimulation induced the expression of Fas , caspase 8 , cellular FLIP Bfl 1 / A1 , and Bcl 10 , but not FasL , TNFR p 55 , Bak , Bax , and Bad at the transcriptional level . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
A pro apoptotic protein Bax is a Bcl 2 family member and forms homodimers and also heterodimerizes with death antagonists , Bcl 2 and Bcl XL . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
However , whereas combination treatment applied to in vitro cell culture was characterized by a significant up regulation and activation of Bax and down regulation of Bcl xL , the treatment applied to tumors induced Bak and Bcl xS , whereas Bcl omega and Bcl xL were down regulated . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
METH induced apoptotic cell death and mRNA expression of pro apoptotic proteins ( bax and DP 5 ) , but not anti apoptotic proteins ( bcl 2 and bcl XL ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
As ( 2 ) O ( 3 ) induced apoptosis was associated with reduced deltapsi ( m ) , enhanced generation of intracellular ROS , decreased levels of intracellular GSH , release of cytochrome c and AIF from the mitochondria , activation of caspases , down regulation of Bcl 2 and Bcl 10 ( L ) , and up regulation of Bax expression . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
AIMS : To investigate whether specific patterns in the expression of apoptosis related proteins correlate with carcinoma type and / or prognosis METHODS : The expression of Fas , Bcl 2 , Bax , Bcl xl , cyclooxygenase 2 ( COX 2 ) , and inducible nitric oxide synthase ( iNOS ) was studied immunohistochemically and the extent of apoptosis and proliferation was investigated in 11 cases of intestinal type and in eight cases of diffuse type carcinoma . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Overexpression of FLAP did not alter Bcl xL protein expression , but did decrease Bax protein and somewhat increased COX 1 and COX 2 mRNA levels . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Treatment of cells with tetrandrine caused the upregulation of p 53 , downregulation of Bcl 10 ( L ) , cleavage of Bid and Bax , and release of cytochrome c , which were accompanied by activation of caspases 9 , 3 and 8 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Enforced expression of PIM 2 ( 34 kDa ) kinase does not appear to regulate expression of BCL 2 , BCL xL , BIM , or BAX proteins . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In contrast , there was no change detected in Fas , Fas associated death domain , Bcl 2 , Bcl xl , Bax , p 53 , or XIAP ( 10 linked inhibitor of apoptosis protein ) expression up to 12 h after poly ( 1 : C ) transfection . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Overexpression of Hsp 10 and Hsp 60 increased the abundance of the anti apoptotic Bcl xl and Bcl 2 , and reduced the protein content of the pro apoptotic Bax . ^^^ Hsp 60 interacted with Bcl xl and Bax in the cardiomyocytes in vivo . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Whereas an upregulation of Bcl xL and a downregulation of Bax seemed to contribute to decreased apoptosis in burn rat neutrophils at 2 h of incubation , the decreased apoptosis at 8 h appeared to be associated with a decrease in Bax and increased phosphorylated Bad . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Based on the structural homology between Bcl 10 ( L ) and Bax , we predicted that binding of Bim to Bax would require displacement of the Bax penultimate alpha helix . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Analysis of the expression of the members of the Bcl 2 family indicated that the synthetic glucocorticoid increased Bax protein levels without affecting the levels of Bcl 2 , Bcl XL , Bcl XS , or Bak . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The intrinsic pathway is regulated by Bax and Bcl XL and involves Bax induced mitochondrial dysfunction and release of cytochrome c as antecedent events leading to caspase 3 activation . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
A decrease in the anti apoptotic protein , Mcl 1 , was detected in HT and NE treated HL 60 cells , whereas other Bcl 2 family proteins including Bax , Bcl 2 , Bcl XL , and Bag remained unchanged . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Increased expression of Bcl 2 and Bax , but not of Bcl 10 , occurs in the penumbra at the time when Bax translocates from the cytosol to the mitochondria , cytochrome c is released to the cytoplasm and active caspase 3 is expressed . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
To explain this intriguing differential sensitivity between unstimulated CD34+ cells versus those stimulated by Epo + KL , we examined the expression of apoptosis regulating genes ( FLIP , BCL 2 , BCL XL , BAD and BAX ) in these cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
These events were associated with Bcl 2 cleavage , Bax , Bak , and Bad accumulation , mitochondrial translocation of Bax , abrogation of Mcl 1 , Bcl xL , and XIAP upregulation , and a marked induction of JNK and p 53 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
It is hypothesized that the balance of proapoptotic ( Bad , Bax ) and antiapoptotic ( Bcl 2 , Bcl Xl ) proteins determines apoptosis . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Examination of Bcl 2 , Bcl 10 and bax protein expression in psoriasis . ^^^ METHODS : Twenty six lesional biopsy samples of 26 patients with psoriasis and five control specimens from normal skin were studied by immunohistochemical method for the differential expression of pro apoptotic bax and antiapoptotic bcl 2 and bcl 10 proteins . ^^^ RESULTS : Compared with the normal epidermis , bcl 2 expression was significantly reduced , whereas bax and bcl 10 were significantly overexpressed in the psoriatic epidermis . ^^^ The localization of bcl 2 / bax / bcl 10 proteins in the psoriatic epidermis did not show a significant deviation from that in the normal epidermis . ^^^ CONCLUSION : These findings indicate a discordant expression of bcl 2 and bax / bcl 10 in psoriatic epidermis . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
METHODS : TUNEL staining , immunohistochemical staining for Ki 67 , p 53 , Bcl 2 , Bcl 10 ( L ) and Bax were performed on paraffin embedded specimens obtained from 11 H . pylori negative controls , 20 H . pylori positive chronic gastritis , 10 chronic gastritis with intestinal metaplasia ( IM ) , 11 adenoma , and 7 adenocarcinoma patients . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Computational modeling predicts a binding site for AA in the extended hydrophobic groove on BCL 10 ( L ) , previously identified as an interface for dimerization to BAX and related proapoptotic proteins . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
A PUMA BH 3 peptide can induce Bax conformational change , cytochrome c release , and reduction in the mitochondrial membrane potential ( DeltaPsi ( m ) ) in isolated K 562 mitochondria and can be inhibited by Bcl XL . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Specifically rasagiline activates Bcl 2 , Bcl xl , protein kinase C ( PKC ) and reduces Bax in a variety of cells including PC 12 and neuroblastoma human dopamine derived SH SY5Y cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
GEC on plastic exhibited increased caspase 8 and 9 activities , increased expression of the proapoptotic protein , Bax , and decreased the antiapoptotic protein , Bcl XL , compared with collagen . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
It induced apoptosis as shown by : ( 1 ) decreased Bcl 2 and Bcl 10 ( L ) proteins and increased Bax protein ; ( 2 ) activation of caspase 3 ; and ( 3 ) increased shedding of apoptotic cells in the medium . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In the present study , we found that formation of TR3 / RXRalpha heterodimers in the nucleus and their subsequent translocation into the cytoplasm , in association with regulation of apoptosis related proteins Bcl 2 , Bcl xl and Bax , was critical for apoptosis induction by ATRA in breast cancer cells MCF 7 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Antiapoptotic family proteins such as Bcl 2 and Bcl 10 ( L ) function , at least in part , by binding proapoptotic members such as Bax and Bak and thereby preventing release of apoptotic proteins , including cytochrome c , from the mitochondria . `` BH 3 only ' ' members of the family disrupt this interaction by binding , via their BH 3 domain , to a hydrophobic pocket on the surface of the antiapoptotic members . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The general consensus in the literature is that pro apoptotic Bax is decreased with melanoma progression while anti apoptotic Bcl xL and Mcl 1 appear to increase with progression . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Further , chemotherapy did not cause a compatible change in expression levels of proteins such as Bcl 2 , Bcl 10 ( L ) , Bax , cIAP 2 , XIAP and survivin . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
To investigate the mechanisms responsible for survival and apoptosis / anoikis in normal human intestinal epithelial crypt cells , we analyzed the roles of various signaling pathways and cell adhesion on the expression of six Bcl 2 homologs ( Bcl 2 , Bcl XL , Mcl 1 , Bax , Bak , Bad ) in the well established HIEC 6 cell model . ^^^ For example , the inhibition of the PI 3 K / Akt 1 pathway down regulated Bcl XL , Mcl 1 , and Bad , while at the same time up regulating Bax , whereas the inhibition of Fak up regulated both Bax and Bak , down regulated Bad , and did not affect the other Bcl 2 homologs analyzed . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Pharmacological calpain inhibition during spontaneous and Fas receptor induced neutrophil apoptosis prevented cleavage of Bax into an 18 kDa fragment unable to interact with Bcl xL . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
This family of proteins now includes both anti apoptotic molecules such as Bcl 2 and Bcl 10 ( L ) , and pro apoptotic molecules such as Bax , Bak , Bid , and Bad . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Through this study , we found that , in wild type embryos , ( 1 ) apoptosis is much more frequent ( approximately 10 times ) in the male than in female germ cells , and ( 2 ) expression of Bcl xL , but not that of Bax , is higher in female than in male germ cells , at around E13 . 5 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In a mouse lung epithelial cell line ( MLE 12 ) , the overexpression of Bcl XL protected cells against hyperoxia by preventing the activation of Bax at the mitochondrial membrane . ^^^ Bax activation at the mitochondrial membrane requires the generation of ROS and can be prevented by the overexpression of Bcl XL . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Ether lipid resistant S49ar cells were cross resistant to extracellular stress factors ( cold shock , heat shock , H2O2 , dimethylsulfoxide ) and to radiation induced apoptosis but not to physiological apoptotic signals ( dexamethasone , growth factor deprivation , thapsigargin , C 2 ceramide ) and expressed similar levels of the apoptosis regulating proteins Bcl 2 , Bcl 10 , Bax , Bad and Bak as did the parent S49wt cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
This includes well established events such as activation of BCL 2 via translocations in follicular lymphoma , as well as more recent observations implicating activation of Bcl 10 ( L ) expression and frameshift and missense mutations of BAX and BCL 2 in cancer . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Atypical antipsychotics attenuate neurotoxicity of beta amyloid ( 25 35 ) by modulating Bax and Bcl 10 ( l / s ) expression and localization . ^^^ Treatment with Abeta ( 25 35 ) , however , did result in mitochondrial translocation of Bax , which effectively increased the mitochondrial ratio of Bax to Bcl 10 ( L ) . ^^^ Treatment of PC 12 cell cultures with Abeta ( 25 35 ) did not significantly alter total cellular expression levels of Bax , a proapoptotic Bcl 2 family member , or levels of Bcl XL , an antiapoptotic analogue . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Pro death Bax increased , while anti death Bcl 2 and Bcl XL decreased , and apoptotic TUNEL positive cells were detected in the hippocampus of klotho mutant mice at the age of 7 weeks . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Examination of apoptosis related proteins by immunoblot analysis revealed levels of BCL 2 , BCL 10 ( L ) , and Bax to be unaffected by celecoxib . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
On the basis that Bax and Bad were augmented in B 1a cells , and Bcl 2 and Bcl xL reduced , we conclude that the disappearance of B 1a cells , but not B 1b , in IL 10 / mice results from their enhanced susceptibility to apoptosis . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Indeed , cytochrome c was not released to the cytosol ; Bax and caspase 9 and 3 were not involved ; overexpressed Bcl xL did not block the death ; and the mitochondrial ultrastructure was not changed . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The aim of this study was to evaluate odontogenic myxomas for the expression of cell cycle protein Ki 67 , apoptosis regulating proteins Bcl 2 , Bcl XL , Bak , and Bax , and matrix metalloproteinases MMP 2 , MMP 3 , and MMP 9 . ^^^ Twenty six paraffin embedded tissue sections were used in a standard immunohistochemistry protocol and incubated with one of the following antibodies : Bcl 2 , Bcl XL , Bak , Bax , or Ki 67 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Inhibition of the NO production led to decreased rate of apoptosis accompanied by downregulation of the proapoptotic molecule Bax and increased expression of the antiapoptotic molecule Bcl 2 and Bcl 10 ( L ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The apoptosis of endothelial cells induced by halysase is closely associated with activation of caspase 3 and decreased level of Bcl 10 ( L ) / Bax . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The change in the expression of Bcl 2 , Bcl 10 ( L ) , and Bax in response to hop bitter acids was studied , and the Bcl 2 protein level slightly decreased ; however , the Bcl 10 ( L ) protein level was obviously decreased , whereas the Bax protein level was dramatically increased , indicating that the control of Bcl 2 family proteins by hop bitter acids might participate in the disruption of mitochondrial integrity . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
METHODS : We screened Bcl w , Bcl 10 , and Bax ( members of Bcl 2 family ) using polymerase chain reaction and singlestrand conformation polymorphism analysis . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Of the apoptotic mediators tested , the anti apoptotic protein Bcl 10 ( L ) was strongly down regulated by combined treatment of the cells with SBHA and TRAIL but not by the HDAC inhibitor alone , while little or no change in the expression of other Bcl 2 family members highly expressed in MM cells , including Mcl 1 and Bax , was observed . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
METHODS : We performed semi quantitative RT PCR to examine the expression level of bak , bax , bcl 2 and bcl xL in 70 % hepatectomized rat livers during the whole regeneration process and compared to that of the sham and normal groups . ^^^ RESULTS : The expression of bak and bax was decreased whereas that of bcl 2 and bcl xL was increased in hepatectomized animals compared to normal liver at most time points . ^^^ CONCLUSION : The expression changes of bak , bax , bcl 2 and bcl xL genes are altered not only due to regeneration , but also due to effects of surgical operations . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Prognostic value of immunohistochemical expression of p 53 , bax , Bcl 2 and Bcl xL in resected non small cell lung cancers . ^^^ METHODS AND RESULTS : We investigated the immunohistochemical expression of p 53 and Bcl 2 gene family members ( bax , Bcl 2 and Bcl xL ) in 94 non small cell lung cancer specimens to establish the role of these genes in lung cancer pathogenesis , and to evaluate their prognostic importance . ^^^ We also found frequent over expression of bax and Bcl xL to be of no prognostic significance . ^^^ Finally , we found no correlation between frequent detection of aberrant p 53 protein and expression of either Bcl 2 , bax or Bcl xL or with patient survival time . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In addition , the apoptotic process involves activation of caspase 9 , a decrease of Bcl 2 as well as Bcl XL levels , and an increase of Bax levels . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bcl 2 family members ( Bcl 2 , Bax , Bcl w and Bcl 10 ( L ) ) are crucial integrators of signals for cell survival and death ; the pro or antiapoptotic activities of these proteins are regulated by their subcellular localization . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Western blot and immunofluorescence analysis revealed that the anti apoptotic Bcl 2 and Bcl xL levels were downregulated , together with the pro apoptotic Bax protein . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In this paper we demonstrate that the SAH region in Siva 1 is sufficient to specifically interact with the anti apoptotic members of the BCL 2 family such as BCL XL and BCL 2 but not its apoptotic member BAX . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
When cells were co transfected with the GFP gene and the bcl 2 family genes bcl 2 , bcl 10 ( L ) , and bax , mitochondria appeared to aggregate at the periphery of the nucleus specifically where GFP was expressed . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Additionally , we found that cycloheximide treatment appeared to downregulate the Bcl xL mRNA level but not the Bax mRNA level by RNase protection assay . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The level of the pro apoptotic regulator Bax peaked after 6 h and then returned to normal , whereas the level of the anti apoptotic regulator Bcl xL , which is presumably induced in order to inhibit apoptosis , started to increase at 6 h , and remained high for 24 h . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The propensity of mitochondria to undergo permeability transition in the presence of a Ca2+ overload was determined along with distribution of various apoptotic regulators ( AIF , Smac 2 , Bax , cytochrome c , Bcl XL , Bfl 1 , and caspase 2 ) between mitochondria and cytoplasmic fractions . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Anti apoptotic Bcl 2 and Bcl XL , pro apoptotic Bax , caspase 3 and caspase 9 expression and activation were analysed using Western immunoblots and densitometry . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Additional unique oncogenic signals occur in pretumorigenic CD 45 ( / ) p 56 ( lck F505Y ) thymocytes in which p56lck kinase activity is 2 to 3 fold higher relative to p 56 ( lck F505Y ) : inhibition of DNA repair , inhibition of DNA damage induced Bcl XL deamidation , Bax conformational change and mitochondrial translocation , cytochrome c release , and the apoptotic caspase execution cascade . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Resveratrol selectively down regulated the expression of antiapoptotic proteins Bcl 10 ( L ) and myeloid cell differentiation factor 1 ( Mcl 1 ) and up regulated the expression of proapoptotic proteins Bax and apoptosis protease activating factor 1 ( Apaf 1 ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We investigated the impact of anti apoptotic Bcl xL protein and its antagonist Bax on gemcitabine induced apoptosis in human pancreatic carcinoma cells in vitro and in vivo . ^^^ The level of Bcl xL and Bax expression was determined in 3 established pancreatic cancer cell lines that differ in their sensitivity to gemcitabine mediated apoptosis . ^^^ Bcl xL and Bax genes were transduced into Colo 357 cells by retroviral infection . ^^^ The impact of Bax / Bcl xL expression on gemcitabine sensitivity in vivo was evaluated in orthotopic Colo 357 tumors in SCID mice . ^^^ Caspase 8 and Bid were cleaved in Colo 357 cells exposed to gemcitabine , and there was no correlation with either Bcl xL or with Bax expression . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The expression of the cyclin dependent kinase ( CDK ) inhibitor p21WAF1 / CIP1 was markedly reduced , but neither Bcl 2 nor Bcl xL or Bax were modulated by c Src inhibition . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
These results came along with a low level of the anti apoptotic proteins Bcl 2 and Bclx ( L ) in Wmyo , whereas there was an increase in the level of the pro apoptotic molecule Bax when compared to the results obtained for Fb and Hmyo . ^^^ Hmyo showed a higher level of Bcl 2 compared to Fb but no difference in the Bax or Bclx ( L ) level . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Exercise did not change the expression of antiapoptotic ( bcl xL ) and apoptotic ( bax and bcl xS ) genes in neutrophils from immature rats but caused a significant increase of bax and bcl xS expression and provoked a significant decrease of bcl xL expression in cells from mature rats . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The administration of appropriate doses of quinapril , losartan , or triple therapy to spontaneously hypertensive rats + subtotal nephrectomy normalized systolic blood pressure , partially prevented proteinuria , renal lesions and apoptosis , and decreased Bax , but no changes were noted in Bcl xL . ^^^ The Bax / Bcl xL index was significantly increased in spontaneously hypertensive rats + subtotal nephrectomy compared to sham operated spontaneously hypertensive rats and decreased in treated groups . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We found that cytosolic localization of endogenous wild type or trans activation deficient p 53 was necessary and sufficient for apoptosis . p 53 directly activated the proapoptotic Bcl 2 protein Bax in the absence of other proteins to permeabilize mitochondria and engage the apoptotic program . p 53 also released both proapoptotic multidomain proteins and BH 3 only proteins [ Proapoptotic Bcl 2 family proteins that share only the third Bcl 2 homology domain ( BH 3 ) ] that were sequestered by Bcl xL . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We assessed survivin expression in ovarian carcinoma , correlating results with expression of other anti apoptotic ( bcl 2 , bcl 10 , mutant p 53 ) and pro apoptotic ( bax ) markers , with prognostic parameters , and prognosis . ^^^ Paraffin embedded sections of 49 ovarian carcinoma were immunostained for survivin , bcl 2 , bcl 10 , bax , and p 53 . ^^^ Frequency of survivin , bcl 2 , bcl 10 , bax , and p 53 was 73 . 5 % , 36 . 7 % , 93 . 9 % , 77 . 6 % , and 60 . 4 % , respectively . ^^^ Survivin expression did not correlate with bcl 2 , bcl 10 , or bax expression , stage , or overall or disease free survival . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Expression levels of p 53 , Bcl 2 , Bcl xL , Bad , Bax , survivin , Caspase 3 and poly ( ADP ribose ) polymerase ( PARP ) were evaluated by immunoblot analysis . ^^^ During the induction of apoptosis , expression of Bcl 2 , Bcl xL and survivin was decreased , and that of p 53 , Bad and Bax was increased . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Diploid human lung fibroblasts were incubated with 3 9 uM Na2CrO4 , and RNA was isolated at 4 , 8 , and 24 h , as well as 24 h after Cr ( 6 ) exposure was terminated ( recovery ) . mRNA expression was quantitated by RNase protection assay with a 32P labeled multi transcript probe containing gene sequences for the cdk inhibitors , p21waf1 / cip1 , p27kip1 , p16INK4a , p15INK4b ; the pro apoptotic proteins bcl XS and bax ; the anti apoptotic proteins bcl W , bcl XL , and bcl 2 , GADD 45 , and cyclin A . ^^^ Of particular interest is that bax expression was reduced , in a dose and time dependent fashion , however that of bcl XS was elevated by nearly 3 fold after 8 h , and declined to control levels at the end of the recovery period . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The ability of RB + AR to induce mitochondria damage was dependent on the proapoptotic proteins Bax and Bak and could be blocked by the antiapoptotic protein Bcl 10 ( L ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
This evidence that ER induced apoptosis mediated by the mitochondrial pathway was additionally supported by the finding that levels of Bcl 2 , Bcl xl , and XIAP protein were significantly lower ( P < 0 . 01 ) , and levels of Bax and Apaf 1 were elevated ( P < 0 . 02 ) in ER carcinomas versus those carcinomas from control or ER REP rats . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
An early ( 2 3 days post CCI ) E2F1 and p 53 independent apoptosis appeared in the spinal cord as the pro apoptotic bax gene increased ( 320 + / 19 % ) , followed by an increased expression of the anti apoptotic bcl 2 and bcl xL genes ( 60 + / 11 % and 110 + / 15 % , respectively ) 7 days from CCI . ^^^ Despite the MPEP treatment , which normalised bax / bcl 2 and bcl xL / bcl xS ratios at all times post CCI , mechanical hyperalgesia reappeared by 7 days after CCI . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Resveratrol treatment also up regulated the Bax protein and mRNA expression in a dose dependent manner ; however , Bcl 2 and Bcl xL levels were not significantly affected . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Neutralization of endogenous BAFF and APRIL by soluble TACI and BCMA decoy receptors attenuates the survival of NHL B cells , decreases activation of the prosurvival transcription factor NF kappaB , down regulates the antiapoptotic proteins Bcl 2 and Bcl 10 ( L ) , and up regulates the proapoptotic protein Bax . ^^^ Conversely , exposure of NHL B cells to recombinant or myeloid cell derived BAFF and APRIL attenuates apoptosis , increases NF kappaB activation , up regulates Bcl 2 and Bcl 10 ( L ) , and down regulates Bax . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
No modifications of Bcl 2 , Bcl 10 , and Bax levels were observed , as well as no changes in Pi3K / Akt and JAK / STAT pathways that are often constitutively active in these cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
METHODS : Total 40 nasal polyps biopsies were detected the expression of Bcl 2 , Bax , Bcl xL as well as Fas protein on eosinophils by immunohistochemistry . ^^^ The expression of Bax , Bcl xL , Fas on eosinophils in 15 nasal polyps explants which cultured with or without erythromycin were detected also . ^^^ RESULTS : In nasal polyps , the expression of Bcl 2 , Bax , Bcl xL and Fas protein on eosinophils are 5 % ( 2 / 10 ) , 65 % ( 26 / 40 ) , 40 % ( 16 / 40 ) and 90 % ( 36 / 40 ) respectively . ^^^ After cultured with erythromycin , the expression of Bax protein increased ( P < 0 . 05 ) , but the expression of Bcl xL and Fas protein had not changed . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In addition , other proteins of the BCL family are overexpressed in MCL like BCLX , whereas the expression of BAX and BAK was not elevated in MCL . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
K 562 R and LAMA R cells that were markedly resistant to induction of mitochondrial dysfunction ( e . g . loss of mitochondrial membrane potential , Bax translocation , cytochrome c , and apoptosis inducing factor release ) and apoptosis by imatinib mesylate exhibited a pronounced reduction in expression of Bcr / Abl , Bcl 10 ( L ) , and STAT 5 but a striking increase in levels of activated Lyn . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The anchorage dependent growth of these cells was decreased due to increased cell cycle arrest in S G2 / M phase ; however , the surviving cells developed resistance due to an increased Bcl xL to Bax ratio . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Survivin , bcl 2 , bax , and bcl 10 gene expression in sentinel lymph nodes from melanoma patients . ^^^ PURPOSE : The expression of apoptosis related genes , such as survivin , bcl 2 , bcl 10 , and bax , has been evaluated by reverse transcriptase polymerase chain reaction ( RT PCR ) and by immunohistochemistry in sentinel lymph nodes ( SLNs ) from melanoma patients and then correlated to the outcome of patients . ^^^ After RNA extraction , an RT PCR followed by Southern blot hybridization was performed to detect survivin , bcl 2 , bcl 10 , and bax mRNA . bcl 2 , survivin , and bax gene expression was evaluated , whenever possible , also by immunohistochemistry at the protein level . ^^^ We did not find a significant correlation between bcl 2 , bax , and bcl 10 gene expression and outcome of patients . ^^^ CONCLUSION : Our findings show a variable expression of apoptosis related genes in SLNs of melanoma patients ; more interestingly , we found that survivin expression correlates to outcome of patients in a statistically significant way , whereas the expression of other genes , such as bcl 2 , bax , and bcl 10 , did not seem to correlate to progression of disease . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Here , we report that rasagiline ( 0 . 1 10 microM ) decreased apoptosis via multiple protection mechanisms , including the stimulation of PKC phosphorylation ; up regulation of PKCalpha and PKC mRNAs , induction of Bcl xL , Bcl w , and brain derived neurotrophic factor ( BDNF ) mRNAs ; and down regulation of Bad and Bax mRNAs . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Expression of biomolecular markers ( Ki 67 , PCNA , Bcl 2 , BAX , BclX , VEGF ) in breast tumors . ^^^ We carried out a retrospective immunohistochemical study of Ki 67 , PCNA , Bcl 2 , BAX , BclX , and VEGF expression in tumors of two groups of breast cancer patients with favorable and unfavorable course of the disease . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Lastly , the presence of either one of these antioxidants in the treatment medium also attenuated Cd induced Cyt c release in cytosol and the level of Bax in the mitochondria after 24 and 48 h , while high Bcl xL expression was observed . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Percentages of CD8+Annexin V+ ( ANX+ ) and CD8+CD95+ cells , changes in mitochondrial membrane potential and levels of expression of Bcl 2 , Bcl XL , and Bax in CD8+ T lymphocytes were measured by quantitative flow cytometry . ^^^ Circulating CD8+ but not CD4+ T cells in patients were found to contain higher levels of proapoptotic Bax and antiapoptotic Bcl XL ( P < 0 . 01 ) than NC cells . ^^^ The Bax / Bcl XL ratio discriminated AD from NED patients . ^^^ Up regulated Bax and Bcl XL expression , the elevated Bax / Bcl 2 ratio and its association with ANX binding implicate the mitochondrial pathway in death of CD8+ T cells of patients with SCCHN . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Antisense transfected cells expressed high levels of Bax and Bak , but low levels of Bcl 2 and Bcl XL when treated with CDDP , peplomycin , 5 fluorouracil or gamma rays . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In contrast to reported observations in acute promyelocytic leukemia , myeloma cell apoptosis was not associated with either the downregulation of Bcl 2 protein or with alterations in the expression of other Bcl 2 family members , Bax , Bak , Bag , and Bcl xl . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Data are described on a retrospective immunohistochemical study of the Ki 67 , PCNA , Bcl 2 , BAX , BclX and VEGF expression in tumors of two groups of patients with breast cancer ( BC ) and with the favorable and unfavorable clinical courses . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Alterations in the cellular distribution of bcl 2 , bcl 10 and bax in the adult rat substantia nigra following striatal 6 hydroxydopamine lesions . ^^^ In this study we examined the localization of the pro apoptotic protein bax , and the anti apoptotic proteins bcl 2 and bcl 10 ( L ) in the substantia nigra ( SN ) of the adult rat and their response to oxidative stress caused by striatal injections of 6 hydroxydopamine ( 6 OHDA ) . ^^^ Our data show that bcl 2 , bcl 10 and bax proteins are present in the SN . ^^^ Bcl 10 staining in neurons was weak , though it was strongly expressed in GFAP positive astrocytes . 6 OHDA injections , which resulted in loss of dopamine neurons between 7 14 days post lesion , altered the distribution of bax , bcl 2 and bcl 10 proteins in the SN . ^^^ While the neuronal distribution of bcl 2 and bcl 10 does not change following lesion , bax became evenly distributed thought the soma . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Here , we report on the membrane insertion properties of different segments from antiapoptotic Bcl 10 ( L ) and proapoptotic Bax and Bid , that correspond to defined alpha helices in the structure of their soluble forms . ^^^ According to prediction methods , there are only two putative TM fragments in Bcl 10 ( L ) and Bax ( the C terminal alpha helix and alpha helix 5 ) and one in activated tBid ( alpha helix 6 ) . ^^^ Surprisingly , the amphipathic helices alpha 6 of Bcl 10 ( L ) and Bax and alpha 7 of Bid do insert in membranes only as part of the alpha 5 alpha6 ( Bcl 10 ( L ) and Bax ) or alpha 6 alpha7 ( Bid ) hairpins but not when assayed individually . ^^^ Membrane insertion fragments of Bcl xL , Bax , and Bid . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In general agreement with activation of the intrinsic caspase pathway , cell death correlated with reduced BCL XL expression and with increased levels of the pro apoptotic proteins BAD and BAX . ^^^ Inhibition of caspase 9 after combination treatment blunted neither JNK1 / 2 / 3 activation nor the enhanced expression of BAD and BAX , but did block caspase 3 cleavage , reduced expression of BCL XL and inhibition of ERK1 / 2 activity . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Expression of Bcl 2 family member proteins Bcl xL , Bcl 2 , and Bax were assessed in glioma cells both before and after chemotherapy treatment . ^^^ Down regulation of Bcl xL and Bcl 2 resulted in reversal of the ratio of Bax / Bcl xL and Bax / Bcl 2 and enhanced cell death after treatment with BCNU . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Regarding the antiapoptotic mechanisms , we have previously demonstrated that under staurosporine treatment , HalphaA and HalphaB crystallins can interact with Bax and Bcl XS , proapoptotic members of the Bcl 2 family , to sequester their translocation into mitochondria , and thus prevent the staurosporine induced apoptosis . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In addition , release of cytochrome c from mitochondria , down expression of Bcl 2 and Bcl 10 ( L ) , up regulation of Bax , and caspase 9 activities were observed in SM treated A 549 cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We determined p 53 , proapoptotic protein Bax , antiapoptotic Bcl xL , proliferating cell nuclear antigen ( PCNA ) and apoptotic index at the early stages of regenerative process after NO increase by lipopolysaccharide induction ( LPS ) of inducible type nitric oxide synthase ( iNOS ) and by direct NO donor ( sodium nitroprusside , SNP ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Consistent with these findings , apoptosis induced by phenylurea based compounds was not altered by genetic alterations in the expression of Bcl 2 family proteins that control mitochondria dependent cell death pathways , including over expression of anti apoptotic proteins Bcl 2 or Bcl 10 ( L ) and genetic ablation of pro apoptotic proteins Bax and Bak . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
EGCG differentially regulated the expression of genes and proteins ( Bax , p 21 , Retinoblastoma , cyclin D 1 , CDK 4 , Bcl 10 ( L ) ) more than 2 fold , showing a possible gene regulatory role of EGCG . ^^^ And Bax , PCNA , and Bcl 10 are important in EGCG mediated apoptosis . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
This effect was found to correlate with the up regulation of Fas / APO 1 , Fas ligand , and Bax , and down regulation of NF kappaB , Bcl 2 , and Bcl XL . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In parallel cultures , there was a significant increase in Bad and Bax expression , concomitant with an increase in DNA fragmentation , and a significant decrease in Bcl 2 and Bcl XL expression . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Using indirect inmunohistochemical method , the expression of Bcl XL and Bax , anti and proapoptotic proteins of Bcl 2 family , as well as of cytokine IL 1beta were studied to demonstrate the role of these substances in apoptosis regulation of sensory neurons of different subpopulations after the severance of their peripheral processes . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Hypoxia induced renal epithelial cell death through caspase dependent pathway : role of Bcl 2 , Bcl xL and Bax in tubular injury . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The expression of important proapoptotic ( Bcl xs , Bax , p 53 , caspase 3 ) and antiapoptotic genes ( Bcl 2 and Bcl xL ) was also altered by tumor cachexia . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In this investigation , we used human 1321N1 astrocytoma cells expressing a recombinant P2Y2 receptor to assess the role of this receptor in the regulation of anti apoptotic ( bcl 2 and bcl xl ) and pro apoptotic ( bax ) gene expression . ^^^ Acute treatment with the P2Y2 receptor agonist UTP up regulated bcl 2 and bcl xl , and down regulated bax , gene expression . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Activation of different initiator and effector caspases , Bax and Bcl xL expression , mitochondrial cytochrome c release and activation of PKB / Akt were analyzed by use of synthetic caspase substrates and Western blotting , respectively . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Here , we found that shikonin induced apoptotic cell death was accompanied by upregulation of p 27 , p 53 , and Bad and down regulation of Bcl 2 and Bcl 10 ( L ) , while shikonin had little effect on the levels of Bax protein . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
HUVECs in vitro expressed Bcl 2 , Bcl xL , and Bax ; however , expression was not changed by SNAP treatment in the presence or absence of LLL CHO , etoposide , or C 2 ceramide . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The pro apoptotic protein Fas , FasL , Bax and the anti apoptotic protein Bcl 2 , Bcl 10 ( L ) , Bcl 2 alpha were studied immunohistochemically by SP method . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Studies of the interaction of substituted mutants of BAX with yeast mitochondria reveal that the C terminal hydrophobic alpha helix is a second ART sequence and plays a role in the interaction with anti apoptotic BCL xL . ^^^ Also , opposite to a mutation that changes the conformation of the N terminal ART , the mutations in the C terminal part of the protein impaired the inhibitory effect of anti apoptotic BCL xL over BAX insertion , suggesting that the conformation of the alpha 9 helix plays a significant role in BAX / BCL xL interaction . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Combined treatment with low concentrations of these two agents also acted synergistically to induce apoptosis in HepG 2 cells through induction of Bax and Apaf 1 , reduction of Bcl 2 and Bcl xL , and activation of caspase 3 , 8 , and 9 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Furthermore , the balance between pro apoptotic ( i . e . , Bax ) and anti apoptotic ( i . e . , Bcl 2 or Bcl xL ) proteins , which was rather pro apoptotic after IR exposure , became anti apoptotic 24 h later , suggesting a protective effect . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Moreover , we found that the TG 2 BH3 peptides as well as TG 2 itself were able to interact with the pro apoptotic Bcl 2 family member Bax , but not with anti apoptotic members Bcl 2 and Bcl 10 ( L ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Furthermore , a marked down regulation of the expression of the Bcl 2 , Bcl XL and XIAP , and up regulation of the Bax and Bad proteins were noted . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In a third series of experiments , expression of mRNA for bcl 10 and bax was measured by Northern analysis of CL treated without and with day 16 PE using cRNA probes for bcl 10 and bax developed in our laboratory by RT PCR . ^^^ Treatment with PE significantly reduced bax mRNA levels but did not change bcl 10 mRNA levels . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The expression of Bcl 2 , Bcl xl , Bak and Bax proteins in axons of the optic nerve in closed angle glaucoma ] . ^^^ PURPOSE : The aim of our study was the evaluation of Bcl 2 , Bcl xl , Bak and Bax immunoexpression in axons of the optic nerve with absolute glaucoma . ^^^ The samples were immuno stained with antibodies for Bcl 2 , Bak , Bax and Bcl xl protein . ^^^ RESULTS : In our study proapoptotic Bak and Bax protein expression was stronger than antiapoptotic Bcl 2 , Bcl xl protein expression ; Bak / Bcl 2 ( p = 0 . 008 ) , Bax / Bcl 2 ( p = 0 . 0007 ) , Bak / Bcl xl ( p = 0 . 0356 ) , Bax / Bcl xl ( p = 0 . 0077 ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Western blotting analyses revealed that IFN gamma dramatically increased the protein levels of interferon regulatory factor ( IRF ) 1 , but not TRAIL receptors ( DR 4 and DR 5 ) and pro apoptotic ( FADD and Bax ) and anti apoptotic factors ( Bcl 2 , Bcl XL , cIAP 1 , cIAP 2 and XIAP ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
While SCF up regulated the expression of the anti apoptotic proteins Bcl 2 and Bcl xL , it did the opposite to the pro apoptotic factor Bax . ^^^ The PI3K inhibitor reversed the regulation of SCF on Bcl xL and Bax but not on Bcl 2 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The combination treatment activated caspase 3 and cleaved PARP , but it did not induce any notable change in the expression of Bcl XL , Bcl 2 and Bax compared with each single treatment . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The growth inhibitory effects of resveratrol are mediated through cell cycle arrest ; upregulation of p21Cip1 / WAF1 , p 53 and Bax ; down regulation of survivin , cyclin D 1 , cyclin E , Bcl 2 , Bcl xL and clAPs ; and activation of caspases . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
MATERIALS AND METHODS : The combined immunohistochemical expression levels of the proteins bax , bak , bad , bid , bcl 2 and bcl xl were evaluated by cluster and discriminant analysis . ^^^ RESULTS : Cluster analysis produced : a ) a low expression ( 69 / 79 cases ) and a high expression pro apoptotic cluster ( 10 / 79 cases ) for the combined expression levels of the pro apoptotic proteins bax , bak , bad and bid and b ) a low expression ( 37 / 76 cases ) and a high expression antiapoptotic cluster ( 39 / 76 cases ) for the combined expression levels of anti apoptotic proteins bcl 2 and bcl xl . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In the present paper , we demonstrate that the absence of apoptosis in HIV 1 infected primary human monocyte differentiated macrophages ( MDM ) correlates with an increase in anti apoptotic ( Bcl 2 and Bcl 10 ( L ) ) and a decrease in pro apoptotic ( Bax and Bad ) proteins . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Western blot analysis was used to evaluate the level of ICAD , ERK / p ERK , JNK / p JNK , and Bcl 10 ( L ) / Bax expression . ^^^ Up regulation of mitochondrial Bax expression and down regulation of Bcl 10 ( L ) expression also participated in the apoptosis induced by NCTD . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Western blot analyses were performed on cultured seminiferous tubule segments for Bcl 2 family proteins ( Bax , Bad , Bcl w , Bcl xL ) and fas ligand . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
No effect of the two cytokines on major members of apoptosis regulating systems ( CD 95 , CD95L , bcl 2 , bax , bcl xL , p 53 , p21WAF1 , p 27 , NFkappaB ) could be observed . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bcl 2 and Bcl XL inhibit apoptosis by binding to proapoptotic proteins such as Bax , thereby preventing chemotherapy induced or radiation induced release of cytochrome c from mitochondria and subsequent activation of the caspase protease cascade . ^^^ Peptides were quantitatively examined for their ability to inhibit Bax / Bcl 2 and Bax / Bcl XL heterodimerization in vitro and to promote cytochrome c release from mitochondria isolated from Jurkat , HL 60 , U 937 , and PC 3 cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Apoptosis induced by BaP 1 on endothelial cells was independent of two Bcl 2 family members ( anti apototic Bcl xL and pro apoptotic Bax ) , that did not show any changes in their expression during a 24 h treatment period . ^^^ In conclusion , treatment of human endothelial cells with BaP 1 induces apoptosis / anoikis , independently of Bcl 2 family members Bax and Bcl xL and associated with caspase 8 activation and cFLIP ( L ) up regulation . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
HMBA , used at cytostatic concentrations , reduced the ratio be tween antiapoptotic ( Bcl 2 , Bcl XL ) and proapoptotic ( Bax ) members of the Bcl 2 family of proteins , thus lowering the threshold for MM cell death commitment . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Using lysate RNase protection assays , mRNA expression of the anti cell death genes Bcl 2 and Bcl xL , and the pro cell death gene Bax , was evaluated following experimental brain injuries in adult male Sprague Dawley rats . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Our results demonstrated that 16 genes ; bad , bax , bcl 2 , bcl w , bcl 10 , caspase 3 , caspase 7 , caspase 8 , c myc , E 124 , GADD 45 , mdm 2 , NKkappab 1 , p 53 , p 21 , Rb and trail were up regulated and six genes ; caspase 1 , caspase 2 , DR 5 , E2F1 , FasL and iNOS did not changed in response to DES treatment in wild type mice compared to p53+ / knockout mice . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Overexpression of Bcl 2 or Bcl 10 ( L ) , loss of Bax or Bak function , high expression of inhibitor of apoptosis proteins , and reduced release of second mitochondria derived activator of caspases ( Smac / Diablo ) from the mitochondria to the cytosol have all been reported to result in TRAIL resistance in mitochondria dependent type 2 cancer cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
AIM : To observe the relationship between apoptosis of mouse thymic lymphocytes and the expressions of bax , bcl 2 and bcl 10 ( L ) after gamma ray radiation with lethal dose and provide the basis for treatment of acute severe radiation sickness . ^^^ The expressions of bax , bcl 2 and bcl 10 ( L ) were detected by in situ hybridization and immunohistochemical staining . ^^^ Increased Bax and decreased Bcl 10 ( L ) expressions in lymphocyte suggest that both of them play an important role in thymic lymphocyte apoptosis caused by lethal dose radiation . . ^^^ Relationship between apoptosis of mouse thymic lymphocytes and expressions of bax , bcl 2 and bcl XL after gamma ray radiation with lethal dose ] . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The expression of Bcl 2 family members , Bcl xL , Bcl 2 , Mcl 1 and Bax was investigated in delayed apoptosis of canine neutrophils induced by lipopolysaccharide ( LPS ) . ^^^ By real time quantitative PCR analysis , it was indicated that Bcl xL and Bax levels in canine neutrophils were significantly affected by LPS stimulation . ^^^ The levels of Bcl xL , Bcl 2 , Mcl 1 and Bax transcripts at 9 h incubation in neutrophils stimulated by LPS ( 100 ng / ml ) were increased by about 80 . 4 , 1 . 9 , 1 . 4 and 5 . 3 folds , in comparison to those in non stimulated neutrophils , respectively . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The expression of Bcl 10 ( L ) protected MLEC against H / R induced cell death by blocking Bax and Bid translocation and inhibiting mitochondrial cytochrome c release . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Treatment with dmPGE 2 did not alter bax or bcl 10 expression but suppressed bax translocation to the mitochondrial membrane . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
An up regulated expression of Bcl 2 and Bcl 10 ( L ) proteins was observed in ECSC in comparison with ESCwE and NESC , whereas the levels of Bax , Bad , Fas and Fas ligand proteins in ECSC were similar to those in ESCwE and NESC . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Western blot analysis showed that combinations of ICI 182780 and BE 3 3 3 caused down regulation of the anti apoptotic Bcl 2 and Bcl XL proteins and increased the level of the pro apoptotic Bax protein . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
All patients were treated by BOAI , and expression of cancer cell apoptosis was examined by the TUNEL method , expression of bax , bcl 2 and bcl xL proteins were examined by immunohistochemistry , and expression of bax , bcl 2 and bcl xL mRNA was examined by quantitative RT PCR before and 3 days after BOAI . ^^^ These results suggest that bax / bcl xL expression can be used as an indicator of the effectiveness of BOAI therapy . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Hence , TFEC induced necrotic cell death in the TAMH cell line is mediated by BAX and antagonized by the anti apoptotic BCL 2 family member , BCL xL . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Although most studies focus on phosphorylation of pro and antiapoptotic proteins ( BAD , Bax , Bcl 2 , Bcl xL ) , kinase mediated regulation of complex 1 activity , anion and cation channels , metabolic enzymes , and Mn SOD mRNA has also been reported . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
N Bak interacts with Bcl XL but not BAX , suggesting an indirect mechanism for promoting Bax translocation to the mitochondria . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Expression of cellular proteins Bcl 10 ( L ) , XIAP and Bax involved in apoptosis in cells infected with herpes simplex virus 1 and effect of pavine alkaloid ( ) thalimonine on virus induced suppression of apoptosis . ^^^ The expression of three cellular proteins involved in the modulation of apoptosis , namely antiapoptotic Bcl 10 ( L ) and XIAP and proapoptotic Bax , was investigated in cells infected with Herpes simplex virus 1 ( HSV 1 ) . ^^^ In addition , the expression of Bcl 10 ( L ) , XIAP and Bax was studied in cells infected with HSV 1 and treated with pavine alkaloid ( ) thalimonine . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The mechanism of neuroprotective activity has been attributed to the ability of propargylamines inducing the antiapoptotic family proteins Bcl 2 and Bcl xl , while decreasing Bad and Bax and preventing opening of mitochondrial permeability transition pore . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Cotreatment with 17 AAG and SAHA also induced down regulation of Mcl 1 , Bcl xL , and B Raf ; up regulation of Bak ; cleavage of 14 3 3 proteins ; and a profound conformational change in Bax accompanied by translocation to the membrane fraction . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The major antiapoptotic family members , Bcl 10 ( L ) and Bcl 2 , and the major proapoptotic proteins , Bax and Bak , show distinct temporal and spatial patterns of expression in the developing brain . ^^^ Targeted deletions of Bcl 10 ( L ) and Bcl 2 as well as Bax and Bak have proven to be important tools in delineating the process of cell death in the nervous system . ^^^ These genetic models show that Bcl 10 ( L ) and Bax play crucial roles in regulating the survival of differentiating neurons . ^^^ Bax , Bcl 10 ( L ) , and Bcl 2 regulate the apoptotic response to neurotrophic factor deprivation . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
METHODS : Apoptosis of human hepatoblastoma cell lines HepG 2 ( p 53 wild ) , Hep3B ( p 53 null ) and PLC / RPF / 5 ( p 53 mutant ) infected with Ad TIP 30 ( bearing a wild type human Tip 30 gene ) were analyzed and p 53 , Bax and Bcl xl expression levels were compared among these cells . ^^^ MTT assay , DNA fragmentation , in situ 3 ' end labeling of DNA , annexin 5 FITC staining were used to detect cell death and apoptosis in cells at various time intervals subsequent to infection , and to determine whether TIP 30 had an effect on the expression levels of some apoptosis related gene products such as Bax , p 53 and Bcl xl . ^^^ In contrast , ectopic expression of TIP 30 in Hep3B and PLC / RPF / 5 cells had no effect on the regulation of Bax expression , but had an effect on Bcl xl levels . ^^^ In comparison with HepG 2 cells , these data suggested that up regulation of p 53 levels by TIP 30 might be a pre requisite for Bax and Bax / Bcl xl ratio increase . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Combined exposure to flavopiridol and HA 14 1 was associated with down regulation of Mcl 1 and Bcl xL , Bid cleavage , and mitochondrial translocation of Bax . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Apoptosis was assessed in various types of gliomas and was defined by the apoptotic index ( IA ) and shown immunohistochemically with using Bcl 2 , Bax and Bcl 10 antibodies . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Inhibition of apoptosis closely correlated with sequestration of Bax , Bid and BAD in the mitochondrial inner membrane , increased Bcl 2 and Bcl 10 ( L ) , and inability to process p 21 Bid . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Overexpression of Bcl 10 ( L ) rescued NUB 7 from apigenin induced cell death , suggesting that Bax activity is important for the action of apigenin . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
As expected ( ) gossypol induced complete cytochrome c release from mitochondria , increased caspases 3 and 9 activity , and caused apoptotic death without affecting protein levels of Bcl 2 , Bcl 10 ( L ) , Bax , and Bak . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
This review notably summarizes the present knowledge of the ( de ) regulation of the effects of androgens , p 53 , Bcl 2 , Bcl xL , Bax , Akt , PTEN , Par 4 , clusterine , caspases and NF kappaB in prostate adenocarcinoma cell lines and provides an appraisal of their therapeutic potential . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Our results also show that Bcl 2 , Bcl 10 ( L ) and Bax protein levels and heterodimerization are selectively regulated by NMDA and non NMDA receptor stimulation . ^^^ In contrast , changes in Bax protein levels are not required for KA induced apoptotic cell death , but decreased levels of both Bax : Bcl 2 and Bax : Bcl 10 ( L ) heterodimer levels are necessary . ^^^ Intrastriatal grafting of a BDNF secreting cell line counter regulated p AKT , Bcl 2 , Bcl 10 ( L ) and Bax protein levels , prevented changes in the heterodimerization between Bax and pro survival proteins , and blocked caspase 3 activation induced by excitotoxicity . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The expression of regulating molecules was analyzed by Western blotting for p 53 , p 21 ( WAF1 / CIP1 ) , and the Bcl 2 family , such as Bcl 2 , Bax , and Bcl 10 ( L / s ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In the SCP group , p 53 protein expression was observed in 30 cases ( 66 . 6 % ) , Ki 67 in 14 ( 31 . 1 % ) , PCNA in 44 ( 97 . 8 % ) , Bcl 2 in 24 ( 53 . 3 % ) , Bak in 28 ( 62 . 2 % ) , Bax in 31 ( 68 . 9 % ) , and Bcl xl in 11 ( 100 % ) . ^^^ In the SCC group , p 53 protein expression was evaluated in 8 cases ( 72 . 8 % ) , Ki 67 in 2 ( 18 . 2 % ) , PCNA in 8 ( 72 . 7 % ) , Bcl 2 in 5 ( 45 . 4 % ) , Bax and Bak both in 10 ( 90 . 9 % ) , and Bcl xl in 100 % . ^^^ In the BCC group , p 53 protein expression was estimated in 23 cases ( 85 . 1 % ) , Ki 67 in 13 ( 48 . 1 % ) , PCNA in 26 ( 96 . 2 % ) , Bcl 2 in 13 ( 48 . 1 % ) , Bak in 21 ( 77 . 8 % ) , Bax in 22 ( 81 . 5 % ) , and Bcl xl in 23 ( 85 . 2 % ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Human colon cancer cells lacking Bax resist curcumin induced apoptosis and Bax requirement is dispensable with ectopic expression of Smac or downregulation of Bcl XL . ^^^ Curcumin induced release of cytochrome c , Second mitochondria derived activator of caspase ( Smac ) and apoptosis inducing factor ( AIF ) was also blocked in Bax / cells and reintroduction of Bax , downregulation of the antiapoptotic protein Bcl XL by antisense DNA as well as the overexpression of Smac , highly sensitized the Bax / cells toward curcumin induced apoptosis . ^^^ The present study demonstrates the role of Bax but not Bak as a critical regulator of curcumin induced apoptosis and implies the potential of targeting antiapoptotic proteins like Bcl XL or overexpression of proapoptotic proteins like Smac as interventional approaches to deal with Bax deficient chemo resistant cancers for curcumin based therapy . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Fucoxanthin treatment caused cleavages of procaspase 3 and poly ( ADP ribose ) polymerase without any effect on the protein level of Bcl 2 , Bcl 10 ( L ) , or Bax . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We identified early proapoptotic transcriptional changes , including upregulation of proapoptotic Bax and downregulation of antiapoptotic Bcl xL , Bcl 2 , and Bcl w , using Affymetrix DNA microarrays . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Regarding the antiapoptotic mechanisms , we have previously demonstrated that under staurosporine treatment , HalphaA and HalphaB crystallins can interact with Bax and Bcl XS , proapoptotic members of the Bcl 2 family , to sequester their translocation into mitochondria , and thus prevent the staurosporine induced apoptosis . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The expression of bcl xL mRNA was significantly decreased in the OP treated groups , whereas the expressions of bcl 2 and bax mRNA were not significantly changed . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Apoptosis was assessed by DNA laddering , localizing apoptotic bodies using immunofluorescent labeling of DNA fragments ( the terminal deoxynucleotidyl transferase mediated dUTP nick end labeling method ) , and immunohistochemical assessment of apoptosis markers bcl 2 , bcl 10 , and bax . ^^^ Immunostaining for bcl 2 was higher in hCG and progesterone treated cycles , whereas bax expression was decreased and bcl 10 immunostaining was not different between treatments . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The effects of Bcl xL overexpression , Bax antisense oligodeoxynucleotides , and different caspase inhibitors on cell death were studied . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Furthermore , exposure of VSMCs to high glucose markedly increased the abundance of Bcl 2 and Bcl xl mRNAs compared with treatment with normal glucose , while expression of bax and IAP 1 mRNA remained unchanged . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
METHODS : We examined the expression pattern of bax , bcl 2 , bcl xL , mtd , and bcl w both at messenger RNA ( mRNA ) and protein level in the brain tissues during the formation of epilepsy with kindling model in adult rats , which has been the most acceptable form of experimental model of human epilepsy . ^^^ CONCLUSIONS : Our study shows differential expression of Bax and Bcl xL at the CA 1 region during the formation of hippocampal kindling model . ^^^ The absence of DNA fragmentation during this period suggests that epileptic changes in neurons have the potential to induce DNA fragmentation by altering the expression levels of Bax and Bcl xL . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We have evaluated the expression and mutational status of p 53 and the expression of bcl 10 ( L ) and bax in a series of 62 consecutive children ( median age : 4 years ; 38 males and 24 females ) affected by de novo ALL . ^^^ Alterations and overexpression of p 53 were uncommon events ( 9 / 62 , 14 . 5 % ) while bcl 10 ( L ) and bax overexpression were frequent ( about 70 % ) . ^^^ In conclusion , both bcl xL and bax were frequently expressed at high intensity , but only bcl xL was an independent predictor of EFS in our series . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Antiapoptotic ( Bcl 2 and Bcl 10 ( L ) ) and proapoptotic ( Bax and Bad ) proteins were expressed in neonatal rat hearts of both groups . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Specifically , we observe that Abeta significantly reduces expression of antiapoptotic Bcl w and Bcl 10 ( L ) , mildly affects expression of bim , Bcl 2 , and bax , but does not alter expression of bak , bad , bik , bid , or BNIP3 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Suppression of chondrosarcoma cells by 15 deoxy Delta 12 , 14 prostaglandin J 2 is associated with altered expression of Bax / Bcl xL and p 21 . ^^^ The preliminary results of cDNA microarray analysis showed the down regulation of anti apoptotic Bcl xL and up regulation of pro apoptotic Bax in the process of 15d PGJ ( 2 ) induced apoptosis . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
This study focused on the immunohistochemical detection of the expression levels of Bcl 2 family regulators ( anti apoptotic Bcl 2 and Bcl XL , pro apoptotic Bcl Xs and Bax ) , p 53 , and PCNA as a marker of proliferation , together with the evaluation of the level of apoptosis in human embryos ( anlage of limbs , axial skeleton , metanephros , and intestine ) . ^^^ The role of pro apoptotic members of Bcl 2 family remains ambiguous , as TUNEL positive cells are both Bax / Bcl Xs positive and negative . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Increase of Bax / Bcl XL ratio and arrest of cell cycle by luteolin in immortalized human hepatoma cell line . ^^^ Luteolin also activated casepase 3 , increased Bax protein with a concomitant decrease in Bcl XL level . ^^^ Increase in Bax / Bcl XL ratio and activation of caspase 3 supported the apoptotic finding on gel electrophoresis . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The expression levels of Survivin , Bcl xl , Bax and glyceraldehyde 3 phosphate dehydrogenase ( GAPDH ) messenger RNA ( mRNA ) were analyzed quantitatively by reverse transcriptase polymerase chain reaction ( Rt PCR ) . ^^^ RESULT : Compared with Puerarin groups , VSMC activity in daidzein groups was lower , and the ratio of Bax / Gapdh / Bcl xl / Gapdh was higher . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
CD 40 activation stimulated both anti apoptotic Bcl XL and pro apoptotic Bax mRNA synthesis in the Daudi cell line ; CD 40 activation increased the Bax mRNA level but had no effect on the Bcl XL mRNA level in the XG 2 cell line . ^^^ Apoptosis in both cell lines was associated with an increasing ratio of Bax to Bcl XL both in mRNA and in protein levels . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
There was no significant change in bcl 10 or bax . ^^^ Therefore bcl 10 and bax do not appear to have a significant role in apoptosis in the first trimester in vitro . ^^^ Using in vitro model for studying the induction and inhibition of spontaneous apoptosis in human first trimester placental villi , mediated by the free radical scavenger SOD , we have examined the expression of bcl xL , bax , Caspase 3 and PARP ( Poly ADP ribosyl ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The cleavage of the proapoptotic Bcl 2 proteins , such as Bad and Bax to produce their truncated forms , and the cleavage of the antiapoptotic Bcl 2 proteins , such as Bcl 2 and Bcl XL , into their potent pro apoptotic fragments were detected in our study . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The constitutive expression of antiapoptotic proteins Bcl 2 and Bcl xl were decreased after silymarin treatment , whereas the expression of the proapoptotic protein Bax was increased . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Different protein regulators of apoptosis , such as Bcl 2 , BclX , and Bax have an influence on the rate of apoptosis in various tumors . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The antiapoptotic proteins , Bcl 2 and Bcl xl , were downregulated by GSP , whereas the expression of the pro apoptotic protein , Bax , and the levels of cytochrome c release , Apaf 1 , caspase 9 , and cleaved caspase 3 ( p 19 and p 17 ) were markedly increased in JB 6 C141 cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
PC 12 cells exposed to H ( 2 ) O ( 2 ) underwent apoptotic cell death as determined by internucleosomal DNA fragmentation and an increased pro apoptotic Bax to anti apoptotic Bcl 10 ( L ) ratio . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Several BH 3 peptides relieved the inhibition of Bax caused by the antiapoptotic Bcl 10 ( L ) and / or Mcl 1 proteins , some displaying a specificity for either Bcl 10 ( L ) or Mcl 1 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
There was a decrease in the expression of anti apoptotic Bcl 2 and Bcl xL proteins , whereas pro apoptotic Bax was increased . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In the 6th and 8th week of intrauterine development we observed isolated TUNEL positive epithelial cells only and this was accompanied by the disperse presence of PCNA as well as by all the studied proteins : Bcl 2 , Bax , Bcl XL , c myc , N myc , p 53 , p 63 and p 73 . ^^^ The separation of primitive crypts and villi was not accompanied by any differences in distribution of Bax , Bcl XL , c myc , N myc , p 63 and p 73 proteins between those compartments : all the studied proteins showed dispersed character . ^^^ In the presence of Bcl 2 , Bax , Bcl XL , p 63 and p 73 we did not find any dramatic changes . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Glutamate excitotoxicity decreased bcl 2 , bcl 10 ( L ) , and bax mRNA levels , . ^^^ NMDA increases Bcl 2 and Bcl 10 ( L ) protein levels and decreases Bax protein levels . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Interestingly , apoptotic +SA cells showed a paradoxical decrease in mitochondrial levels of pro apoptotic proteins Bid , Bax , and Bad , and a corresponding increase in mitochondrial levels of anti apoptotic proteins , Bcl 2 and Bcl xL , suggesting that mitochondrial membrane stability and integrity might actually be enhanced for a limited period of time following acute tocotrienol exposure . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Western blot analyses revealed that CT induced an elevation of bcl xL but not bcl 2 or proapoptotic factors bax , bak , and bad . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Indeed , bortezomib induced increases of Bik and / or Bim in multiple cell lines but not notably of two other BH 3 only proteins ( Puma and Bid ) nor other family members ( Bax , Bak , Bcl 2 , and Bcl xL ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Connexin 26 correlates with Bcl xL and Bax proteins expression in colorectal cancer . ^^^ AIM : To evaluate of Cx 26 in correlation with Bcl xL and Bax proteins in colorectal cancer . ^^^ METHODS : Immunohistochemical staining using specific antibodies was performed to evaluate the protein expression of Cx 26 , Bax and Bcl xL in 152 colorectal cancer samples and the correlations among studied proteins as well as the relationships between the expression of Cx 26 , Bax , Bcl xL and clinicopathological features were analyzed . ^^^ RESULTS : Both normal epithelial cells and carcinoma cells expressed Cx 26 , Bax and Bcl xL , but Cx 26 in cancer cells showed aberrant , mainly cytoplasmic staining . ^^^ Expression of Cx 26 , Bax and Bcl xL was observed in 55 . 9 % , 55 . 5 % and 72 . 4 % of evaluated colorectal cancers respectively . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Activation of caspase 3 as well as the increase in the ratio of Bax to Bcl xl were seen at early time points ( 1 24 h ) as well as in the heart failure stage ( 3 wk ) . ^^^ In contrast , a gradual and persistent increase in p 38 and JNK MAPKs as well as in caspase 3 and the Bax to Bcl xl ratio may contribute in the initiation of apoptosis and progression of heart failure . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Rapamycin induces apoptosis of JN DSRCT 1 cells by increasing the Bax : Bcl xL ratio through concurrent mechanisms dependent and independent of its mTOR inhibitory activity . ^^^ Rapamycin induced apoptosis by increasing the Bax : Bcl xL ratio as a consequence of the concomitant downregulation of Bcl xL and upregulation of Bax , both at the post transcriptional level . ^^^ Transient transfection studies using kinase dead and rapamycin resistant forms of mTOR demonstrated that only the downregulation of Bcl xL was caused by the mTOR inhibitory action of rapamycin , which prevented cap dependent translation initiation , whereas Bax upregulation was induced by rapamycin through a mechanism independent of its mTOR inhibitory activity . ^^^ Treatment of JN DSRCT 1 cells with MG 132 , a proteasome specific inhibitor , also resulted in the induction of apoptosis through a similar increase in the Bax : Bcl xL ratio specifically caused by inhibiting Bax degradation and turnover . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
MX 3350 1 decreased the levels of antiapoptotic Bcl 2 and Bcl XL , increased proapoptotic Bax , induced mitochondrial membrane permeabilization ( MMP ) , and cytochrome c release from mitochondria to cytosol . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
RA repressed c fos mRNA expression in control and irradiated SiHa cultures , but did not repress bcl 10 ( L ) , p 53 , GADD 45 , p 21 , bax , bcl 2 , or mcl 1 mRNA expression . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In both cases , Oc survival was accompanied by analogous rises in the mRNA ratios for anti apoptotic Bcl xL and Bfl 1 relative to pro apoptotic Bax , and by marked protein suppression of the critical pro apoptotic signal Bim . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Prevalence of apoptosis was defined by TUNEL and ISOL staining and further characterized by immunohistochemical staining for caspase 3 , Bcl 2 , BCL 10 ( L ) , Bax , proliferating cell nuclear antigen ( PCNA ) , and Ki 67 . ^^^ The antiapoptotic proteins , Bcl 2 and BCL 10 ( L ) , demonstrated intense upregulation within and surrounding MFL cells , whereas pro apoptotic protein Bax expression was only seen at control level . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Recently , it was discovered that Bcl 10 ( L ) deamidation occurs in vivo , and this results in Bcl 10 ( L ) degradation that sensitizes cells to apoptosis by enhancing BAX activity . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
EXPERIMENTAL DESIGN : We studied whether Bcl 2 , Bcl xL , Mcl 1 , Bax as well as the Bcl 2 / Bax ratio and a combination of all ( antiapoptosis index , AAI ) are related to the frequency of malignant cells surviving the chemotherapy ( i . e . , minimal residual disease , MRD ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Even a single injection of paraquat + maneb in the non transgenic treated group modulated several key pro and anti apoptotic proteins , including Bax , Bad , Bcl xL , and upstream stress induced cascade . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
To characterize the mechanisms of apoptosis induction by proteasome inhibitors , we examined levels of Bcl 2 protein family members ( Bik / NBK , Bax , Bak , Bcl 2 , and Bcl XL ) , release of cytochrome c , and activation of caspase 9 and 3 in human colon cancer cell lines DLD 1 , LOVO , SW 620 , and HCT 116 ; human lung cancer cell line H 1299 ; and human ovarian cancer cell line SKOV 3 after they were treated with bortezomib . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Treatment of human HEK 293 cells with the terephthalamide derivative 26 resulted in disruption of the Bcl 10 ( L ) / Bax interaction in whole cells with an IC ( 50 ) of 35 . 0 microM . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
One day following washout , it was observed that PCP treatment caused an increase in NR 1 , NR2A and Bax polypeptides in the cortex , but had no effect on Bcl xL . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bax , bcl 2 and bcl 10 change their expression in stromal cells , whereas bcl 10 was induced after drug treatment and bcl 2 down regulated in progenitor cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
On the other hand , intracellular levels of the anti apoptotic proteins , such as Bcl 2 and Bcl xL , and the pro apoptotic protein Bax , were assessed during viral infection . ^^^ These analyses showed that as viral infection proceeded , the cellular level of Bcl xL decreased , while the levels of Bax and Bcl 2 remained unaffected . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We discovered that there was high expression in the lens equatorial epithelium ( the region of the lens in which differentiation is initiated ) of pro apoptotic molecules such as Bax and Bcl 10 ( S ) and release of cytochrome c from mitochondria . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
A number of proteins mediated with apoptotic process have been identified , including p 53 , BAX , BCL 2 and BCL 10 . ^^^ In the cultures exposed to pure anoxia , a significant increase of p 53 and BAX immunoreactivity , associated with the decreased level of BCL 2 and BCL 10 immunopositive cells was observed , related to the activation of apoptotic process . ^^^ This strong immunoreactivity of proapototic proteins ( p 53 and BAX ) in hippocampal cultures exposed to anoxia or / and TPEN correlated with previous ultrastructural evidences of anoxia and TPEN induced apoptosis , while the overexpression of anti apoptotic protein ( BCL 2 and BCL 10 ) in zinc pretreated cultures evidenced the protective ability of this metal against apoptosis in model of anoxia in vitro . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
A 12 fold increase in anti apoptotic Bcl 10 ( L ) compared with a 2 fold increase in proapoptotic Bax suggested a balance in favor of antiapoptotic signaling in hibernators . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Deregulation of the apoptotic machinery plays a major role in cell death , cellular transformation and cancer . p 53 , Bcl 2 , Bcl XL , Bax and Mdm 2 mRNA expression patterns were evaluated in tissue samples with cervical intraepithelial neoplasia ( CIN ) and cervical cancer compared to those of normal cervical tissues , and correlated with the underlying cervical lesions . ^^^ Bax and Bcl XL mRNA expression was negatively correlated . ^^^ Mdm 2 transcriptional levels correlated significantly with those of Bax , Bcl XL and Bcl 2 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
These effects of flavokawain A are accompanied by a time dependent decrease in Bcl 10 ( L ) , a decrease in the association of Bcl 10 ( L ) to Bax , and an increase in the active form of Bax protein . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
OBJECTIVES : The present study was designed to analyze the expression of the major antiapoptotic molecules Bcl 2 , Bcl XL and the proapoptotic Bax in pancreatic ductal carcinoma and their correlation to the extent of apoptosis . ^^^ The levels of Bcl 2 , Bcl XL , and Bax mRNA expression were analyzed by semiquantitative reverse transcriptase polymerase chain reaction ( RT PCR ) . ^^^ Semiquantitative RT PCR revealed variable mRNA expression , with the Bcl 2 / Bax ratio ranging from 0 . 2 to 1 . 5 and the Bcl XL / Bax ratio ranging from 0 . 3 to 1 . 8 . ^^^ Immunohistochemical analysis showed positive Bcl 2 , Bax , Bcl XL expression in 20 % , 72 % , and 92 % of cancer samples ; however , their levels were variable . ^^^ However , as compared with the normal pancreas , Bcl 2 , Bcl XL , Bax were overexpressed in most of the pancreatic cancer samples ( Mann Whitney U test , P < 0 . 01 ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Treatment of U 937 cells with MNNG resulted in the inhibition of viability and the induction of apoptosis in a concentration dependent manner , which was associated with a dose dependent upregulation in pro apoptotic Bax protein , downregulation of anti apoptotic Bcl 2 and Bcl xL proteins , and proteolytic activation of caspase 3 protease . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Western blot analysis was used to analyze the expression of p 53 , p 53 phospho Ser 15 , p 21 , Bax , PUMA , and Bcl 10 ( L ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Skin biopsies of LyP ( n = 20 ) and LTCL ( n = 19 ) and five CD30+ lymphoma cell lines were analysed by means of immunohistochemistry and Western blotting in order to evaluate the proliferation ( Ki 67 ) , apoptosis ( FragEl ) and expression of Bax , Bcl 10 , C kit and Mcl 1 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Here we used embryonic fibroblasts derived from mice deficient in the multidomain proapoptotic members of the Bcl 2 family ( Bax and Bak ) and the apoptotic components of the apoptosome ( Apaf 1 and caspase 9 ) to unravel the cascade of events by which Bcl 10 ( S ) promotes apoptosis . ^^^ Our results show that Bak but not Bax is essential for Bcl 10 ( S ) induced apoptosis . ^^^ Bak but not Bax is essential for Bcl xS induced apoptosis . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The present study investigates the expression of apoptotic proteins Bax , Bad , Bcl 2 , and Bcl xl following hypoxia in the cerebral cortex of the guinea pig fetus as a function of gestational age . ^^^ Hypoxia resulted in increased expression of the proapoptotic proteins Bax and Bad by 20 % and 30 % in the preterm as compared to 24 % and 38 % at term , without altering the expression of anti apoptotic proteins Bcl 2 and Bcl xl . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Meanwhile , Bcl xL was upregulated , and Bid activation or translocation , or conformational changes of Bax were not identified . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In order to understand the molecular alterations leading to heterogeneous cisplatin sensitivity and apoptosis inducibility in NSCLC cells , we analyzed various apoptotic pathways , including the activation of caspase 8 , 9 and 3 , the release of cytochrome c from mitochondria and the expression levels of pro and anti apoptotic proteins such as Bax , Bad , Bcl 2 , Bcl xL , Fas and p 53 using heterogeneously apoptosis sensitive cells ( Ma 10 , Ma 31 and Ma 46 ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Both caused apoptosis by increasing the protein expression of Bax and Bcl xs while decreasing Bcl 2 and Bcl 10 ( L ) , releasing apoptogenic cytochrome c , and augmenting the activity of caspase 9 and caspase 3 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Inhibition of core protein expression also altered the expression level of Bcl 2 family proteins , displaying an increase of the proapoptotic Bax and a decrease in the level of the anti apoptotic Bcl xL proteins . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In these models , both SAHA and m carboxycinnamic acid bis hydroxamide induced growth arrest and caspase mediated apoptosis and increased p 21 protein levels , retinoblastoma hypophosphorylation , BH 3 interacting domain death agonist cleavage , Bax up regulation , down regulation of Bcl 2 , A 1 , and Bcl 10 ( L ) expression , and cleavage of poly ( ADP ribose ) polymerase and caspase 8 , 9 , 3 , 7 , and 2 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Several connections were demonstrated between Cox and a few oncogenes ( 5 src , 5 Ha ras , HER 2 \ neu , Wnt , p 53 mutated ) , alimentary products ( PUFAs ) , transcription factors ( c jun and c fos ) , proapoptotic proteins [ Bax et Bcl 10 ( L ) ] or antiapoptotic ( Bcl 2 ) , CYP 19 aromatase gene , NFkappaB receptor ( RANKL ) , angiogenesis ( via VEGF , TXA 2 , oxid nitric synthetase , alphaVbeta 3 integrin receptor ) , peroxisome gamma proliferator receptor ( PPARgamma ) and its ligand PGJ 2 and with antitubuline chemotherapy drugs . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
This work describes the isolation of cDNA and genomic fragments from five sheep BCL 2 related genes : BCL 2 , BCL2L1 , BCL2L2 , BAX and MCL 1 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In addition , we confirm that stabilization of TP 53 and transactivation of pro apoptosis BAX also occurs during the delayed apoptosis and show that anti apoptosis BCL 10 ( L ) is down regulated . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
It is believed that oesophageal cancer has an intricate molecular mechanism of evading apoptosis by the down regulation of Bax , up regulation of Bcl 2 , Bcl xl and Survivin , mutation of p 53 and alteration in Fas expression . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
AIMS : To examine the prognostic relevance of the expression of the Bcl 2 , Bcl xL , and Bax proteins in stage IB squamous cervical carcinoma ( SCC ) . ^^^ Immunohistochemistry using monoclonal antibodies against Bcl 2 , Bcl xL , and Bax was used to examine protein expression . ^^^ RESULTS : Cytoplasmic expression of Bcl 2 , Bcl xL , and Bax was low ( < 5 % positive cells ) in 159 of 220 ( 73 % ) , 193 of 220 ( 87 % ) , and 39 of 220 ( 18 % ) tumours , respectively , and high ( > or = 5 % positive cells ) in 61 of 220 ( 27 % ) , 27 of 220 ( 13 % ) , and 181 of 220 ( 82 % ) tumours , respectively . ^^^ CONCLUSION : Bcl 2 , Bcl xL , and Bax were not independently associated with prognosis in stage IB SCC . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The overexpression of Bcl xL enhances autophagic cell death when apoptotic cell death is inhibited in Bax ( / ) / Bak ( / ) double knockout cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Using immunohistochemistry the groups were compared for expression of apoptotic proteins : bcl 2 , bcl 10 ( L ) , bax , bak and survivin . ^^^ Radioresistant laryngeal cancer was associated with bcl 2 ( P < 0 . 001 ) and bcl 10 ( L ) ( P = 0 . 005 ) expression and loss of bax expression ( P = 0 . 012 ) in pretreatment biopsies . ^^^ The association between expression of bcl 2 , bcl 10 ( L ) and bax with radioresistant cancer suggests a potential mechanism by which cancer cells avoid the destructive effects of radiotherapy . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The p 53 siRNA treated KCs were characterized by elevated E2F 1 levels accompanied by accelerated elimination of the Mcl 1 and Bcl 10 ( L ) antiapoptotic proteins , as well as enhanced Bax oligomerization . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The present study examined the effects of progesterone on mRNA and protein levels of the Bcl 2 apoptosis regulatory genes , bax , bad , bcl 2 , and bcl 10 ( L ) , in cerebral cortex after TBI . ^^^ Our results indicate that bax and bad mRNA levels and Bax and Bad protein expression in the ipsilateral , injured cerebral cortex were significantly elevated post TBI , while mRNA levels of bcl 2 and bcl 10 ( L ) or Bcl 2 and Bcl 10 ( L ) protein expression were not changed . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Western blot analysis revealed that the expression of Bcl xL , Bax , and Apaf 1 was not affected in cells transfected with sense or antisense AP 4 genes . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Also , we found that Bax translocation to mitochondria was associated with the exposure of an NH 2 terminal epitope , and that this translocation could be partially blocked by the prosurvival factors Bcl 2 and Bcl XL . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Polyglutamine expanded ataxin 7 activates mitochondrial apoptotic pathway of cerebellar neurons by upregulating Bax and downregulating Bcl 10 ( L ) . ^^^ Polyglutamine expanded ataxin 7 Q 75 promoted the release of apoptogenic cytochrome c and Smac from mitochondria , which was preceded by the downregulation of Bcl 10 ( L ) protein and upregulation of Bax protein expression in cultured cerebellar neurons . ^^^ Further real time TaqMan RT PCR assays showed that mutant ataxin 7 Q 75 upregulated Bax mRNA level and downregulated Bcl 10 ( L ) mRNA expression in the primary neuronal culture of cerebellum . ^^^ The present study provides the evidence that polyglutamine expanded ataxin 7 Q 75 activates mitochondria mediated apoptotic cascade and induces neuronal death by upregulating Bax expression and downregulating Bcl 10 ( L ) expression of cerebellar neurons . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The expressions of dioxin responsive gene cytochrome P 450 1A1 ( CYP1A1 ) , apoptotic gene Bax , and anti apoptotic genes Bcl 2 and Bcl xL were examined in rat liver and brains using Western blot analysis and RT PCR . ^^^ These results indicate that early exposure of dioxin could affect the development of certain brain regions with gender difference , in terms of its differential effect on expressions of Bcl xL , Bcl 2 , and Bax . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We also studied the expression of estrogen receptors and the levels of anti apoptotic Bcl xL protein , pro apoptotic Bax protein , and messenger RNA in the cells by Western blot and reverse transcriptase polymerase chain reaction analysis . ^^^ The expression of Bcl xL was markedly increased in a dose dependent manner , resulting in an elevated ratio of Bcl xL to Bax . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Immunohistochemical expression of bcl 2 , bcl xL , bax , p 53 proteins in gastric adenoma and adenocarcinoma ] . ^^^ BACKGROUND / AIMS : The aim of this study was to investigate the immunohistochemical expression of bcl 2 , bcl xL , bax , and p 53 proteins according to the pathological parameters such as grade of dysplasia , histological type , depth of invasion , lymph node metastasis , and TNM stage in the gastric adenoma and gastric adenocarcinoma . ^^^ METHODS : Immunohistochemical staining using monoclonal bcl 2 , bcl xL , bax , p 53 antibodies were performed on paraffin embedded specimens from forty one gastric adenomas and 100 gastric adenocarcinomas . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Regulation of apoptosis in granulosa cells was examined by annexin 5 and propidium iodide staining ; measurement of relative levels of mRNA encoding Bcl 2 , Bcl xL and Bax ; and activity of caspase 3 , 8 and 9 . ^^^ The ratios of relative levels of mRNA encoding Bcl 2 to Bax and Bcl xL to Bax were higher on day 6 than days 4 and 8 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
METHODS : NOS isoenzymes , pro ( Bax ) and antiapoptotic factors ( Bcl 2 , Bcl XL ) , and neurotrophic factors ( brain derived neurotrophic factor , BDNF ; neurotrophin 3 , NT 3 ; fibroblast growth factor 2 , FGF 2 ) were determined by immunoblotting in the EL mouse brain at various developmental stages . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Dexamethasone also lowered the increase in the proapoptotic Bax , which was increased by PA , and increased expression of the antiapoptotic Bcl xL protein . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Proteins for Western blot analysis included Fas associated death domain ( FADD ) and caspase 8 for extrinsic pathway , as well as Bcl 2 , Bcl XL , Bax , Bad , Bid , Akt , p Akt , and caspase 9 for intrinsic pathway . ^^^ Levels of FADD , Bax , Bad , and Bid were substantially increased in the TA induced myopathy group , whereas Bcl 2 , Bcl XL , Akt , p Akt , and caspase 9 did not change between control and myopathy groups . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The antiapoptotic activity of BMP 7 in the LNCaP and C 4 2B cell lines was not associated with a significant alteration in the levels of the proapoptotic protein Bax or the antiapoptotic proteins Bcl 2 , Bcl xl , and 10 linked inhibitor of apoptosis . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Further studies were conducted to compare these changes to the localization and expression of the bcl 2 group of proteins bcl 10 , bax and mcl 1 , and Fas Fas ligand in the same cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bcl xL gene transfer inhibits Bax translocation and prolongs cardiac cold preservation time in rats . ^^^ In heart transplantation , overexpression of Bcl xL inhibited Bax translocation from the cytosol to the mitochondria , resulting in decreased cytochrome c release from the mitochondria ; it also significantly decreased cardiac cell apoptosis and improved graft survival rate after long cold preservation , followed by warm reperfusion . ^^^ CONCLUSIONS : Bcl xL gene transfer inhibited the translocation of Bax and prolonged the cold preservation time of cardiac transplants . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In this study we evaluate the expression of apoptosis related proteins of the Bcl 2 family ( Bcl 2 , Bax and Bcl xL ) in the traumatic penumbra area in correlation with the extent of apoptosis in the rat model of focal cerebral contusion , treated by HBO . ^^^ The pathological study was based on immunohistochemical staining of the brain sections for Bcl 2 , Bax and Bcl xL with quantitative evaluation of staining by image analysis . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Cultured Nb cells were sensitized to alpha TOS by pre treatment with Bcl 2 , Bcl xL or Mcl 1 siRNAs , while the malignant cell line was more resistant to the vitamin E analogue when Bax was knocked down . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The proapoptotic BH 3 only protein natural born killer / Bcl 2 interacting killer ( Nbk / Bik ) has been described to inhibit Bcl 2 and Bcl xL , thereby supporting the death promoting ability of Bax . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The expression levels of Mcl 1 and Bcl XL but not those of Bcl 2 , Bax , and Bak were suppressed by TSA or SK 7041 treatment . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We evaluated the levels of Bax , Bcl xL , Bcl 2 and cytochrome c expression by Western blot analysis , and caspase 9 and 3 activities were determined in a colorimetric assay . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Apoptosis of T 24 cells by Chan Su was associated with a down regulation of anti apoptotic Bcl 2 and Bcl 10 ( S / L ) expression and an up regulation of pro apoptotic Bax expression . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In adriamycin treated BALB / 3T3 cells , the down shift in temperature from 37 degrees C to 32 degrees C increased the Bcl xL protein level and decreased the mRNA level of Puma and mitochondrial translocation of Bax , suppressing caspase 9 mediated apoptosis . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
This pathway is regulated by bcl 2 family of anti apoptotic ( bcl 2 , bcl xl , mcl 1 ) and pro apoptotic proteins ( bax , bad , bak ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bax , Bcl 2 , Bcl XL , Bid , cytochrome c and PKCd were detected by Western blotting . ^^^ A decreased expression of Bid was noted , although no significant changes in Bax , Bcl 2 and Bcl XL expression were observed after the combined treatment . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
T 3 inhibited the apoptotic process induced by streptozocin , S Nitroso N Acetylpenicylamine ( SNAP ) , and H2O2 via regulation of the pro and anti apoptotic factors Bcl 2 , Bcl XL , Bad , Bax , and Caspase 3 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The results showed that Bcl 2 family molecules , such as Bid , Bak , and Bax , are involved in the parthenolide induced apoptosis and that the defective expression of Bcl 10 ( L ) might contribute to the higher parthenolide sensitivity in the SCK cells than in the other adenomatous cholangiocarcinoma cells . ^^^ Molecular dissection revealed that Bcl 10 ( L ) inhibited the translocation of Bax to the mitochondria , decreased the generation of intracellular reactive oxygen species , reduced the mitochondrial transmembrane potential ( deltapsi ( m ) ) , decreased the release of cytochrome c , decreased the cleavage of poly ( ADP ribose ) polymerase , and eventually inhibited apoptotic cell death . ^^^ These results suggest that parthenolide effectively induces oxidative stress mediated apoptosis , and that the susceptibility to parthenolide in cholangiocarcinoma cells might be modulated by Bcl 10 ( L ) expression in association with Bax translocation to the mitochondria . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
RT PCR analysis for apoptosis related gene expression showed that the expression of Bax , Bcl 2 , Bcl xL , and Bcl xs genes , which are implicated in mitochondrial pathway , was significantly upregulated in the testes of the treated rats . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The enhanced TRAIL effect after pretreatment with HDAC inhibitors was consistent with the upregulation of the proapoptotic Bcl 2 family members ( Bim , Bak , Bax , Noxa , and PUMA ) , the downregulation of the anti apoptotic members of the Bcl 2 family ( Bcl 2 and Bcl 10 ( L ) ) , and IAPs . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Ellipticine increased the expression of Bax , but decreased the level of Bcl 2 , Bcl XL and 10 linked inhibitor of apoptosis protein ( XIAP ) , and subsequently triggered the mitochondrial apoptotic pathway ( release of cytochrome c , and activation of caspase 9 and 3 ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Treatment of human embryonic kidney 293 ( HEK 293 ) cells with terphenyl derivatives resulted in the disruption of the binding of Bcl 10 ( L ) to Bax in intact cells . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Trauma to the peripheral processes of sensory neurons of different subpopulations was followed by indirect immunohistochemical analysis of the expression of Bcl 10 ( L ) and Bax , which are , respectively , antiapoptotic and proapoptotic proteins of the Bcl 2 family , and also of the cytokine interleukin 1beta , with the aim of identifying the roles of these substances in controlling apoptosis . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Moreover , sulforaphane induced apoptotic cell death was accompanied by upregulation of Bax and downregulation of Bcl 2 and Bcl 10 ( l ) protein . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In the present study , the effects of EtOH on multiple functional mechanisms of Bcl 2 , Bcl xL , and Bax were investigated to characterize further the processes underlying these disparate EtOH sensitivities . ^^^ For these analyses , we addressed the following questions , by using P 4 and P 7 cerebellar tissue following in vivo exposure : 1 ) Are there differential patterns of expression of antiapoptotic Bcl 2 or proapoptotic Bax in EtOH vulnerable Purkinje cells that could contribute to the different degrees of temporal EtOH vulnerability . 2 ) How does EtOH affect intracellular localization of apoptosis related proteins . 3 ) Does cleavage of Bax contribute to EtOH sensitivity . 4 ) Does EtOH differentially modulate cerebellar protein protein interactions of Bcl 2 , Bcl xL , and Bax at the vulnerable vs . the resistant ages . ^^^ Overall , we show that , at P 4 , the EtOH mediated effects on Bcl 2 , Bcl xL , and Bax favor a prodeath response , whereas most of the intracellular responses to EtOH exposure at P 7 promote survival . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Expression of Cdc2 / Cdk 1 , cyclin B 1 , cyclin A , p21 / Cip1 , pRb , pRb2 / p130 , Bcl 2 , Bcl 10 ( L ) , Bax and caspase 3 proteins were studied with western blot analysis . ^^^ Apoptosis markers like Bcl 2 and Bcl 10 ( L ) were significantly decreased and Bax and caspase 3 were increased . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In addition , antiapoptotic Bcl 2 and Bcl 10 ( L ) levels were increased and pro apoptotic Bax and Bak levels were decreased in the HIF 1alpha overexpressing OSCC line . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Antiapoptotic family proteins such as Bcl 2 and Bcl XL function , at least in part , by binding proapoptotic members such as Bax and Bak and thereby prevent release of the apoptotic cascade of events . `` BH 3 only ' ' members of the family disrupt this interaction by binding , via their BH 3 domain , to a hydrophobic pocket on the surface of the antiapoptotic members . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Pro survival factor Bcl 10 ( L ) can antagonize the pro apoptotic functions of Bax and Bad via two distinct mechanisms . ^^^ In order to map the domains of Bcl 10 ( L ) involved in inhibiting Bax and Bad , we have carried out mutational analyses of this protein . ^^^ The resulting Bcl 10 ( L ) mutant constructs were then co transfected with either GFP Bax or GFP Bad . ^^^ We found that the BH 1 4 domains and the C terminal segment of Bcl 10 ( L ) were essential for blocking Bax localization to mitochondria . ^^^ In addition , by immunoprecipitation analyses , we found that these deletions differentially affected the ability of the Bcl 10 ( L ) mutant proteins to bind Bax and Bad . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Similarly , although etoposide induced apoptosis was inhibited in Bax ( / ) / Bak ( / ) mouse embryonic fibroblasts , autophagy was not inhibited , which was regulated by Bcl xL . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Subsequent studies showed that combined treatment with bortezomib or MG 132 resulted in an increase of death receptor ( DR ) 5 and Bik at protein levels but had no effects on protein levels of DR 4 , Bax , Bak , Bcl 2 , Bcl XL or Flice inhibitory protein ( FLIP ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Apoptosis by I3C involves downregulation antiapoptotic gene products , including Bcl 2 , Bcl xL , survivin , inhibitor of apoptosis protein ( IAP ) , 10 chromosome linked IAP ( XIAP ) , and Fas associated death domain protein like interleukin 1 beta converting enzyme inhibitory protein ( FLIP ) ; upregulation of proapoptotic protein Bax ; release of micochondrial cytochrome C ; and activation of caspase 9 and caspase 3 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Similarly , immunoreactivity for the apoptotic signals Fas , Fas ligand , Bax , Bcl 10 , caspase 8 , caspase 9 and caspase 3 was absent from the NBM of AD and control brains . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bcl xL / Bax ratio is altered by IFNgamma in TNFalpha but not in TRAIL induced apoptosis in colon cancer cell line . ^^^ Although the two TNFSF ligands induced a same strong up expression of pro apoptotic Bax gene , the expression of anti apoptotic Bcl xL gene was more strongly up regulated in TNFalpha than in TRAIL stimulated cells . ^^^ Thus , we hypothesize that the Bcl xL / Bax ratio can block the apoptotic response in TNFalpha stimulated cells but allows cell death initiation when it is altered by a crosstalk between IFNgamma presensitization and TNFalpha induced signalings . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Our results show that the ITCs caused phosphorylation of Bcl 2 , induced mitochondrial translocation of Bak , and disrupted the association of Bcl xl with both Bak and Bax in mitochondrial membrane , indicating that ITC induced mitochondrial damage results at least in part from modulation of select Bcl 2 family members . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Pristimerin did not significantly alter the protein level of Bcl 2 family members ( Bcl 2 , Bcl 10 ( L ) , and Bax ) , nor did it induce Bax translocation . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Ataxin 3 Q 79 promoted mitochondrial release of cytochrome c and Smac , which was preceded by the upregulation of Bax protein and downregulation of Bcl 10 ( L ) protein expression . ^^^ Polyglutamine expanded ataxin 3 activates mitochondrial apoptotic pathway by upregulating Bax and downregulating Bcl xL . ^^^ Real time TaqMan RT PCR assays demonstrated that ataxin 3 Q 79 upregulated Bax mRNA level and downregulated Bcl xL mRNA expression in striatal , cerebellar and substantia nigra neurons . ^^^ Our results suggest that polyglutamine expanded ataxin 3 Q 79 activates mitochondrial apoptotic pathway and induces neuronal death by upregulating Bax expression and downregulating Bcl xL expression . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Only infrequently did BAX application result in large conductance channels similar to those produced by a proapoptotic BCL xL fragment or by application of a BH 3 only peptide . ^^^ Injection of BAX into the presynaptic terminal did not abolish synaptic transmission , contrary to previous findings with the proapoptotic fragment of BCL xL . ^^^ Instead , injection of BAX caused an increase in neurotransmitter release , as has also been found for the full length antiapoptotic BCL xL protein . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The effect of short term beta adrenergic stimulation by isoproterenol on the activity of plasma , lung , and left ventricular ( LV ) angiotensin 1 converting enzyme ( ACE ) activity and its association with the development of cardiac apoptosis was investigated . beta Adrenergic stimulation for 24 hours produced an early increase only in the proapoptotic proteins bax and bcl XS without changes in the levels of the antiapoptotic protein bcl XL . ^^^ The administration of perindopril ( an ACE inhibitor ) prevented the observed increase in bax and bcl XS levels and attenuated ( 50 % decrease , P < 0 . 05 ) the effect of isoproterenol on DNA fragmentation . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Although neither the total amounts nor the mitochondrial localization of Bax , Bcl 2 and Bcl xL were affected , caspase 3 activity was increased after NMDA exposure . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Expression of PCNA , p 53 , Bax , and Bcl 10 in oral poorly differentiated and basaloid squamous cell carcinoma : relationships with prognosis . ^^^ BACKGROUND : The aim of this study was to compare the clinical features and proliferating cell nuclear antigen ( PCNA ) , p 53 , Bcl 10 , and Bax expression in primary oral basaloid squamous cell carcinoma ( BSCC ) and poorly differentiated squamous cell carcinoma ( PDSCC ) matched by stage and site and to assess the possible prognostic significance of these variables . ^^^ In addition , PCNA , p 53 , Bax , and Bcl 10 expression in both carcinomas were evaluated in relation to their clinicopathologic features and prognostic values using the Kaplan Meier method and Cox regression models . ^^^ The 5 year and 10 year overall survival , cancer specific survival , and disease free survival rates demonstrated no significant differences between the BSCC and PDSCC groups , and the PCNA , p 53 , Bax , and Bcl 10 also showed no prognostic value . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Expression of the Insulin Receptor Substrate 1 in primary tumors and lymph node metastases in breast cancer : correlations with Bcl xL and Bax proteins . ^^^ The aim of the present study was to assess relationships between IRS 1 expression and anti apoptotic Bcl xL as well as proapoptotic Bax proteins , assessed by immunohistochemistry , in primary tumors and lymph node metastases of breast cancer . ^^^ IRS 1 is positively associated with both Bcl xL and Bax in primary and metastatic tumors . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
MATERIALS AND METHODS : The growth of the colo 201 human colon cancer cell line was examined by colorimetric 3 ( 4 , 5 dimethylthiazol 2 yl ) 5 ( 3 carboxymethoxyphenyl ) 2 ( 4 sulphophenyl ) 2H tetrazolium ( MTS ) assay , while the expression of apoptosis and proliferation related proteins ( p 53 , Bax , Bcl xL and S , Bcl 2 , Caspase 8 , Caspase 3 and proliferating cell nuclear antigen ( PCNA ) ) were examined by Western blotting . ^^^ The expression of an apoptosis suppressing protein ( Bcl 2 ) was down regulated , an apoptosis enhancing protein ( cleaved form of Caspase 3 ) was up regulated , proliferation related PCNA protein was down regulated and p 53 , Bax , Bcl xL and S and Caspase 8 levels were unchanged . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Finally , the analysis of the molecular markers that might be implicated in the synergism between LY 294002 and gemcitabine suggests that PI3K inhibition might aid chemotherapeutic treatment , leading to changes in the balance between anti and pro apoptotic molecules of the Bcl 2 family , Bcl XL and Bax . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
METHODS : Twenty breast cancer patients who were categorized as pre and postmenopausal and 20 mammary gland tumors obtained from dogs were included in this study The expression of Bcl 2 , Bcl 10 ( L ) , Bax , caspases 8 and 3 as well as Hsp 70 and 90 in tumor tissues and adjacent tissues were investigated using Western blotting . ^^^ RESULTS : While expression of Bcl 2 , Bcl 10 ( L ) , Hsp 70 and 90 was increased , expression of Bax and caspases 8 and 3 was significantly lower in both human as well as canine mammary tumor tissues compared to corresponding adjacent tissues . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The number of apoptotic cells in lung sections was determined by a TUNEL method . mRNAs for Fas , FasL and caspase 8 , and for Bad , Bax , Bcl w , Bcl xL and caspase 9 , for the FasL and the mitochondrial cytochrome c pathways of apoptosis , respectively , and mRNA for the effector caspase 3 were quantified in lung tissues by RT PCR . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
NPD 1 is synthesized in RPE cells undergoing oxidative stress , potently counteracts oxidative stress triggered apoptotic DNA damage in RPE , upregulates antiapoptotic proteins Bcl 2 and Bcl 10 ( L ) , and decreases proapoptotic Bax and Bad expression . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In a model of serum withdrawal induced apoptosis of rat pheochromocytoma PC 12 cells , rasagiline and its propargyl moiety , N propargylamine , decreased cell death via multiple neuroprotective pathways that include the stimulation of PKC phosphorylation ; upregulation of PKCepsilon mRNA ; induction of Bcl 10 ( L ) , Bcl w , and brain derived neurotrophic factor ( BDNF ) mRNAs ; and downregulation of PKCgamma , Bad , and Bax mRNAs . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The pro apoptotic proteins Bax and tBid antagonize this effect by blocking the biochemical interaction of Bcl 10 ( L ) with the InsP ( 3 ) R . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Immunoblot analysis revealed that PFE treatment of PC 3 cells resulted in ( 1 ) induction of Bax and Bak ( proapoptotic ) ; ( 2 ) down regulation of Bcl 10 ( L ) and Bcl 2 ( antiapoptotic ) ; ( 3 ) induction of WAF1 / p21 and KIP1 / p27 ; ( 4 ) a decrease in cyclins D 1 , D 2 , and E ; and ( 5 ) a decrease in cyclin dependent kinase ( cdk ) 2 , cdk 4 , and cdk 6 expression . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Immunoblotting analysis showed no upregulation of pro apoptotic proteins ( caspase 2L , 3 , 6 , 8 , 9 , and Bax ) with age while all the anti apoptotic proteins ( caspase 2S , Bcl 2 , and Bcl XL ) remained unchanged during aging . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
As the anti apoptotic Bcl xL gene has been shown to harbour a STAT 5 binding element we measured the expression of Bcl xL as well as the pro apoptotic Bax . ^^^ We found that hGH increased the Bcl xL / Bax ratio both in the absence and in the presence of cytotoxic cytokines . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Ectopic expression of Bcl 2 or Bcl 10 ( L ) was also unable to prevent the flavopiridol / HDACI regimen from inducing a conformational change in and mitochondrial translocation of Bax , and it did not attenuate Bax dimerization . ^^^ As a whole , these findings indicate that in contrast to certain conventional cytotoxic agents such as ara C , overexpression of Bcl 2 or Bcl 10 ( L ) are largely ineffective in preventing perturbations in Bax , mitochondrial injury , and cell death in human leukemia cells subjected to simultaneous CDK and HDAC inhibition . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
PSI induced cell death required RNA transcription and protein synthesis , but not DNA replication , was accompanied by the upregulation of Bcl 2 and modest reduction of Bax and Bcl XL proteins , and involved the activation of caspases 2 , 3 , 7 and 8 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bax and Bcl XL apoptosis protein mRNA in rat brain stem and cortex during ontogeny . ^^^ Bax mRNA level in fetal rat brain stem increases by day 40 of life and then decreases , while level of Bcl XL mRNA reaches the adult value over one month . ^^^ Bax mRNA level in the cerebral cortex decreases from day 8 to day 90 of life , while Bcl XL mRNA level does not change . ^^^ Judging from Bcl XL / Bax mRNA ratio , cortical cells exhibit higher readiness to apoptosis than brain stem cells . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Patterns of expression of Bax , Bcl 2 and Bcl 10 ( L ) in the implantation site in rat during pregnancy . ^^^ Overall Bax and Bcl 2 were expressed from day 8 till day 19 , whilst Bcl 10 ( L ) was extinguished by day 16 . ^^^ The increased levels of active caspase 9 correlated with Bax / Bcl 2 and Bcl 10 ( L ) expression suggesting that the apoptotic mitochondrion dependent pathway is involved in decidual regression during pregnancy progression . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Bcl 2 and Bcl xL expressions were down regulated after paclitaxel treatment in FHIT expressing cells , whereas Bax and Bad expressions were up regulated . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Further investigation showed that silencing of hPEBP 4 in MCF 7 cells promoted TNF alpha induced stability of p 53 , up regulation of phospho p53ser15 , p21waf / cip , and Bax , and down regulation of Bcl 2 and Bcl xL , which were shown to depend on extracellular signal regulated kinase 1 / 2 and c jun NH 2 terminal kinase activation by hPEBP 4 silencing . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Levels of other Bcl 2 family proteins ( Bcl 2 , Bcl 10 ( L ) , Bad , Bak , Bax ) were unaffected by simultaneous ATRA and TGF beta 1 treatment , when compared to ATRA alone . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Active caspase 3 and Bax expressions were increased , whereas antiapoptotic Bcl xl and heat shock protein ( HSP ) 27 expressions in DRGs were increased . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Reactive oxygen species ( ROS ) generation and Bax protein expression in the transfected AHH 1 Bcl xL cells were also lower compared to parental AHH 1 cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
BCL XL , BAX and BCL 2 are members of the BCL 2 protein family known to regulate both apoptotic and necrotic cell death signaling at the mtPTP . ^^^ No significant treatment related alterations in BCL XL , BAX or BCL 2 protein expression are observed in rat tissue homogenates or primary astrocytes . ^^^ However , moderate increases in BCL XL are observed only in DNB treated rat cortical astrocytes , and these increases may be sufficient to shift the constitutive balance in expression of antagonistic to agonistic BCL 2 proteins from a ratio which favors BAX to one in which BAX and BCL XL are comparably expressed . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Upregulation of caspase 1 , 2 , 3 , 6 , 7 , 8 , 11 and 12 and upregulation for the transcripts of apoptosis inhibitors bcl 2 , bcl w and bcl 10 and apoptosis promoters ' bax , bak and bad was detected in spleens of sPCV and mPCV mice , but not control mice . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Western blot showed that LPS in high glucose increased the levels of anti apoptotic Bcl 2 and Bcl 10 ( L , ) and did not change proapoptotic Bax . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Expression profiles of genes , c myc , AT 1 , AT 2 , ETA , ETB , Bcl 2 , Bax and Bcl 10 , were determined by reverse transcription polymerase chain reaction ( RT PCR ) in the acute phase , from 1 to 48 h , following CA arteriotomy . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
HDAC inhibitors enhance the apoptosis inducing potential of TRAIL in leukemia cells ( HL 60 , Jurkat , K 562 , and U 937 ) through multiple mechanisms ; up regulation of DR 4 , DR 5 , Bak , Bax , Bim , Noxa and PUMA , down regulation of IAPs , Mcl 1 , Bcl 2 , Bcl XL and cFLIP , release of mitochondrial proteins ( cytochrome c , Smac / DIABLO and Omi / Htr2 ) to the cytosol , induction of p21WAF1 / CIP1 and p27KIP1 , activation of caspase 3 and cleavage of poly ( ADP ribose ) polymerase ( PARP ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Up regulation of Bad and p 21 ; down regulation of Bcl 2 , Bcl XL , Bid , p 53 , and fatty acid synthase ; and cleavage of Bax were found in HMDB treated A 431 cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Tg betaCTF99 / B6 mouse brain at 12 16 months showed severely down regulated calbindin , phospho CREB , and Bcl xL expression and up regulated phospho JNK , Bcl 2 , and Bax expression . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
This BEA induced apoptosis in human NSCLC A 549 cells was also accompanied by the up regulation of Bax , Bak , and p Bad and down regulation of p Bcl 2 , but no effect on the levels of Bcl 10 ( L ) or Bad proteins . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Expression of pro apoptotic ( p 53 , p 21 , bax , bak and fas ) and anti apoptotic ( bcl 2 and bcl 10 ) proteins in serous versus mucinous borderline ovarian tumours . ^^^ MATERIALS AND METHODS : Immunohistochemical expression of pro apoptotic ( p 53 , p 21 , bax , bak , fas ) and anti apoptotic proteins ( bcl 2 , bcl 10 ) was determined in 34 borderline ( 19 mucinous , 15 serous ) , 20 benign ( 10 mucinous , 10 serous ) and 28 malignant ovarian tumours ( 9 mucinous , 19 serous ) . ^^^ No difference in bax , bak , fas or bcl 10 expression was observed among the three tumour types . ^^^ No difference in p 53 , bax , bak , fas or bcl 10 expression was observed between serous and mucinous borderline ovarian tumours . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
At the same time , p 53 , phospho p 53 ( Ser 15 ) , and other apoptosis related proteins such as Bax , Bcl 2 , Bcl xL , pro caspase 3 , and pro caspase 9 were determined by Western blot analysis . ^^^ An increase in expression of the pro apoptotic factor Bax and a decrease in expression of the anti apoptotic factor Bcl 2 were also observed in a time dependent manner after exposure of 50 microM curcumin , while the expression of the anti apoptotic factor Bcl xL was unchanged . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In addition , chalcone also triggered the mitochondrial apoptotic signaling by increasing the amount of Bax and Bak and reducing the level of Bcl 2 and Bcl 10 ( L ) , and subsequently activated caspase 9 in MCF 7 and MDA MB 231 cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Western blot analysis indicated that the induction of apoptosis by GA and ursolic acid was accompanied with an activation of caspase 8 and a reduction in the anti apoptotic proteins , Bcl 2 and Bcl xL , although the pro apoptotic proteins , Bax and Bak , remained unaffected . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In addition , inhibition of PI 3 kinase did not alter levels of Bax , Bcl 2 , Bcl 10 ( L ) or Bim proteins in mitochondria but caused translocation of the pro apoptotic protein Bad to mitochondria . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
This was accompanied by significant TRAIL and decreased caspase 3 mRNA expression , whereas the expression of Bcl 2 family members was low ( Bcl xl ) or absent ( Bcl 2 , Bax ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Western blot analysis revealed the down regulation of Bcl 2 and Bcl xL and the up regulation of Bax and Bad by cerebral I / R insult . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We also found that Myc reduces the expression of Bcl 2 and Bcl xL and that the apoptosis inducing stimuli up regulate Bax expression . ^^^ These results suggest that up regulation of mtCLIC , together with a reduction in Bcl 2 and Bcl xL , sensitizes Myc expressing cells to the proapoptotic action of Bax . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
While the expression of Bax , Bak , and Bcl 2 was comparable to the wild type cells , the selected clones showed specific up regulation of Bcl XL , an anti apoptotic protein . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
OBJECTIVES : Thus , in the present study , we studied the effects of systemically administered Epo on antiapoptotic ( bcl 2 , bcl XL ) , proapoptotic ( bax and DP 5 ) gene expression following hypoxic ischemic brain injury in neonatal rats . ^^^ Bcl 2 , bcl XL , bax , and DP 5 mRNA expression were analyzed by RT PCR . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Cytosol from untreated cells inhibited heat activated Bax or Bak ; however , depletion of cytosolic Bcl xL ablated this protection . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The levels of adenine nucleotide translocator , voltage anion dependent channel , Bax , Bcl 2 , Bcl xL , AIF and Smac / Diablo , were similar in both cell lines , whereas cytochrome c content was divided by three in the resistant cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Expression of pro survival genes bcl 2 and bcl xl was down regulated by 10 % to 60 % ; expression of the proapoptosis gene bax was up regulated by 23 % to 85 % . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The effects of chronic administration of quetiapine on the phencyclidine induced reference memory impairment and decrease of Bcl XL / Bax ratio in the posterior cingulate cortex in rats . ^^^ PCP induced reference memory impairment , and a decrease of the ratio of an anti apoptotic Bcl 2 family member ( Bcl XL ) to a pro apoptotic analogue ( Bax ) in the posterior cingulate cortex . ^^^ Chronic administration of quetiapine counteracted the PCP induced reference memory impairment and decrease of Bcl XL / Bax ratio in the posterior cingulate cortex . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
A decrease in expression of Bcl 2 , Bcl 10 ( L ) and pro caspase 3 was observed after exposure to 40 microM curcumin , while the levels of p 53 and Bax were increased in the curcumin treated cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Cytotrophoblasts also expressed a 2 fold higher level of p 53 , a 2 fold lower level of 60 kDa Mdm 2 protein , a 2 fold higher level of Bak , but no differences in the expression of 90 kDa Mdm 2 , Bcl 2 , Bcl 10 ( L ) , Mcl 1 , Bax , Bad , and Bad phosphorylated at the serine ( 112 ) , serine ( 136 ) , or serine ( 155 ) sites , compared to the syncytiotrophoblasts . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The down regulation of the cyclin A , Bcl 2 , and Bcl 10 ( L ) expression with the simultaneous up regulation of the p 21 and Bax expression , and caspase 9 activation was observed in ECSC after bufalin treatment . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
After treatment with IDN 5109 , Bcl 2 and Bcl XL were down regulated , Bax was up regulated , and caspase 3 was activated . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The pro apoptotic Bcl 2 family proteins , Bak , Bax , and Bim have been shown to be required for disruption of mitochondria and intrinsic cell death of self reactive B cells whereas the anti apoptotic Bcl 2 , Bcl xL , and Mcl 1 can prevent cell death by interfering with the action of Bax and Bak . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Transient changes in the expression of several apoptosis regulators were identified , including up regulation of Bax and Fas / CD95 and down regulation of Bcl xL and TRAMP / Apo3 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Silymarin pre treatment reversed the effect of UV irradiation on the expression of phosphorylated Akt and phosphorylated p 53 ( regulated by Akt activation ) , followed by down regulation of Bax and up regulated expressions of Bcl 2 and Bcl xL proteins in UV irradiated A 375 S2 cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In order to analyse the relationships between regulation of apoptosis and homologous recombination ( HR ) , we overexpressed proapoptotic Bax or only BH 3 Bid proteins or antiapoptotic Bcl 2 or Bcl XL , in hamster CHO cells or in SV 40 transformed human fibroblasts . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In the study of the molecular mechanism of this phenomenon , it was found that GnTV AS reduced the expressions of anti apoptotic proteins , such as phosphorylated protein kinase B and phosphorylated Bad as well as Bcl 2 and Bcl 10 ( L ) , and elevated those of pro apoptotic proteins , including Bax , full length caspase 3 and its activated fragments as well as anti oncoprotein p 53 . ^^^ The increased active caspase 3 was the consequence of the elevated Bax / Bcl 2 ( Bcl 10 ( L ) ) activity ratio in the cells . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Apoptosis was accompanied by cytochrome c release to the cytoplasm and Bax translocation to the mitochondria , while the levels of the anti apoptotic proteins Bcl 2 and Bcl xL remained unchanged . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Apoptosis induced by each TM was associated with a significant ( approximately 400 % ) increase in caspase 8 activity , but no change in caspase 9 activity , and Western analyses revealed a marked up regulation of Fas ( approximately 500 % ) and FADD ( approximately 300 % ) with no change in expression of Bax , Bcl 2 , or Bcl xL . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Treatment with nifedipine also blocked changes in the anti apoptotic protein bcl xL and in expressions of the pro apoptotic protein bax . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
After treatment with oridonin for 48 hr , the percentage of disruption of delta psi m gradually increased in a dose dependent manner along with marked changes of cell apoptosis , and necrotic cells increased remarkably after the cells were treated with oridonin for 72 hr ; Western blotting showed cleavage of the caspase 3 zymogen protein ( 32 kDa ) with the appearance of its 20 kDa subunit when apoptosis occurred ; expression of Bcl 2 and Bcl XL was downregulated remarkably while expression of Bax and Bid was upregulated concurrently after the cells were treated with oridonin for 24 hr . ^^^ We therefore conclude that oridonin has significant antiproliferation effects on HPB ALL cells by induction of apoptosis as well as directly causing cell necrosis and that oridonin induced apoptosis on HPB ALL cells is mainly related to the disruption of delta psi m and activation of caspase 3 as well as downregulation of anti apoptotic protein Bcl 2 , Bcl XL , and upregulation of pro apoptotic proteins Bax and Bid . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Gene expression levels of pro apoptotic genes ( AT 2 receptor , Fas , Bax and Bcl xS ) have shown to have significant reduction by EGb and Losartan treated groups as compared to vehicle group . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We show that the coexistence of specific mitochondrial signaling defects ( either deletion of Bax , overexpression of Bcl 10 ( L ) , or deletion of Smac ) with expression of 10 linked inhibitor of apoptosis protein decreases the sensitivity of cancer cells to IFN gamma / Apo2L / TRAIL or granzyme B induced apoptosis , lymphocyte mediated cytotoxicity in vitro , and adoptive cellular immunotherapy in vivo . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
To determine whether this phenomenon results from altered expression of Bcl 2 or related proteins , Northern and Western analysis was employed to assess the effects of bryostatin 1 and other PKC activators on steady state levels of Bcl 2 , Bax , Bcl 10 , and Mcl 1 mRNA and protein . ^^^ None of the PKC activators modified expression of Bax or Bcl 10 ( L ) mRNA or protein ; levels of Bcl 10 ( S ) were undetectable in both treated and untreated cells . ^^^ These effects were accompanied by unaltered expression of Bcl 2 , Bax , and Bcl 10 ( L ) , and by a further increase in Mcl 1 protein levels . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The analyzed genes were bax , bcl 2 and bcl 10 , with known responses to genotoxic stress ( bcl 2 ) or ionising radiation ( bax and bcl 10 ) in MCF 7 human breast cancer cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Levels of proapoptotic factors ( bim and bax ) increased and levels of antiapoptotic factors ( bcl 2 and bcl xL ) decreased in a dose dependent manner . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Immunofluorescence analysis indicates that ( DIPP L Leu ) 2 L LysOCH 3 induced upregulation of pro apoptotic Bax and downregulation of anti apoptotic Bcl 2 and Bcl 10 ( L ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Surprisingly , there was no differential expression of important proteins like Bcl 10 ( L ) , Bcl 2 or Bax that might explain enhanced apoptosis . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Relative abundances of transcripts for the glucose transporters Glut 1 , Glut 3 , Glut 4 and Glut 8 , and transcripts involved in the apoptotic cascade , including BAX , BCL XL , XIAP and HSP 70 . 1 , were analysed by a semiquantitative reverse transcription polymerase chain reaction assay in single blastocysts produced in vitro or in vivo for specific time intervals , that is , before or after maternal embryonic transition . ^^^ With the exception of XIAP , no effects of culture system on the mRNA expression patterns of BAX , BCL XL and HSP 70 . 1 could be observed . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Hepatic mRNA levels were measured for several pro apoptotic adaptors / regulators , including FasL , Fas receptor , FADD , TRADD , Bad , Bak , Bax , and Bcl 10 ( S ) , and anti apoptotic regulators , including Bcl w , Bcl 10 ( L ) , Bcl 2 , and Bfl 1 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We detected time and concentration dependent changes in protein expression of anti apoptotic Bcl 10 ( L ) as well as pro apoptotic Bax and Bak proteins . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
These responses on UVB and / or sanguinarine treatments were associated with ( a ) decrease in Bcl 2 and Bcl 10 ( L ) and ( b ) increase in Bax , Bid , and Bak protein levels . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We also show evidence suggesting that IAN 4 and IAN 5 are associated with anti apoptotic proteins Bcl 2 and Bcl xL , whereas IAN 1 is associated with pro apoptotic Bax . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
This sensitizing effect is lost if Bcl 2 expression , but not Bcl xL expression , is knocked down or if cells only express a mutant of Bax that does not interact with Bcl 2 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Moreover , the anti apoptotic proteins Bcl 2 and Bcl 10 were down regulated , whereas pro apoptotic protein Bax remained unchanged . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Treatment with 0 . 4 mmol / L H ( 2 ) O ( 2 ) up regulated Bax but down regulated Bcl 2 in a time dependent manner , while Bcl xL expression remained unchanged . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Death promoting Bcl 2 family members , such as Bax , can promote cytochrome c release and fragmentation of the mitochondrial network , whereas apoptosis inhibitory members , such as Bcl 2 and Bcl xL , can antagonize these events . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Cell death was associated with a decrease and increase in Bcl 10 ( L ) and Bax expression , respectively , as well as release of cytochrome c and translocation of apoptosis inducing factor . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In addition , the results showed that FME induced apoptosis was accompanied by up regulation of Bax and Bad , and down regulation of Bcl 2 and Bcl XL . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
RESULTS : Our results indicated that combined treatment led to an increased apoptotic cell death in U 937 cells , which is correlated with the phosphorylation of the 5 Jun sarcoma virus 17 oncogene homolog ( c JUN ) NH ( 2 ) terminal kinase protein ( JNK ) , the activation of caspases , the increase in B cell leukemia / lymphoma 2 ( Bcl 2 ) associated 10 protein ( Bax ) , the decrease in Bcl xL protein ( Bcl XL ) levels , the loss of mitochondria membrane potential and the release of cytochrome c . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Immunohistochemistry was employed to examine the expression of the antiapoptotic proteins Bcl 2 and Bcl XL and the proapoptotic proteins Bad , Bak , Bax , Bid , Bim , and p 53 in 21 cases of gastric cancer . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The authors tried to determine the responsible molecules ; however , expression of TRAIL receptors ; pro caspase 3 / 8 / 9 ; Fas associated death domain protein ( FADD ) ; tumor necrosis factor receptor 1 associated death domain protein ( TRADD ) ; silencer of death domain ( SODD ) ; FLICE inhibitory protein ( FLIP ) ; and Bcl 2 , Bcl xL , and Bax in FLS was not modulated by IFN gamma . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Among proapoptotic proteins , Bax expression was activated in H ( 2 ) S treated cells but not Bid , and the antiapoptotic proteins Bcl 10 ( L ) and Bcl 2 did not show any activation in pancreatic acinar cell apoptosis . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
ALK 7 ca induced the expression of proapoptotic factor Bax but suppressed the expression of antiapoptotic factors Bcl 2 , Bcl XL , and Xiap . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
PUMA Dissociates Bax and Bcl 10 ( L ) to induce apoptosis in colon cancer cells . ^^^ PUMA interacts with anti apoptotic Bcl 2 and Bcl 10 ( L ) and is dependent on Bax to induce apoptosis . ^^^ Mutant Bcl 10 ( L ) that can not interact with Bax was unable to protect cells from PUMA mediated apoptosis . ^^^ Furthermore , Bax was found to be dissociated preferentially from Bcl 10 ( L ) in HCT 116 cells but not in the PUMA knockout cells , in response to PUMA induction and adriamycin treatment . ^^^ PUMA inhibited the association of Bax and Bcl 10 ( L ) in vitro by directly binding to Bcl 10 ( L ) through its BH 3 domain . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
RESULTS : Cotreatment of Bcr / abl ( + ) cells with minimally toxic concentrations of DMAG and PD 184352 resulted in synergistic induction of mitochondrial injury ( cytochrome c release and Bax conformational change ) , events associated with the pronounced and sustained inactivation of ERK1 / 2 accompanied by down regulation of Bcl 10 ( L ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
PFE pretreatment of NHEK was found to increase the cell cycle arrest induced by UVA in the G 1 phase of the cell cycle and the expression of Bax and Bad ( proapoptotic proteins ) , with downregulation of Bcl 10 ( L ) expression ( antiapoptotic protein ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Rocaglaol treatment induced Bax expression through 12 to 72 h of exposure , while Bcl xl expression was slightly decreased through 48 h , and decreased more significantly by 72 h . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The protein expressions of Bcl XL , Bcl 2 , Bax , cytochrome c and AIF were studied by Western blotting . ^^^ This was accompanied by down regulation of Bcl XL and Bcl 2 and up regulation of Bax . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
In additional studies , treatment of A 431 cells with berberine ( 15 75 microM ) for 72 h resulted in a significant dose dependent increase in apoptosis ( 31 60 % , P < 0 . 05 0 . 001 ) than non berberine treated control ( 11 . 7 % ) , which was associated with an increased expression of pro apoptotic protein Bax , decreased expression of anti apoptotic proteins Bcl 2 and Bcl xl , disruption of mitochondrial membrane potential , and activation of caspases 9 , 3 and poly ( ADP ribose ) polymerase . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Molecular mechanism of cell death was investigated by p 53 , Bcl xL , Bcl 2 , Bax protein , activity of caspase 3 and 12 , and activity of telomerase . ^^^ CIZAR reduced expression of Bcl 2 and Bcl xL proteins but induced expression of Bax protein . ^^^ CIZAR ( R ) prevents the proliferation of OVCAR 3 cells by inactivation of m aconitase activity and induces apoptosis by induction of proapoptotic gene ( Bax ) , repression of antiapoptotic genes ( Bcl 2 , Bcl xL ) , and consequently activation of caspase 3 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The patterns of expression of the Bcl 2 , Bax , and Bcl xL proteins were examined immunocytochemically in rat hippocampus and neocortex after severe hypobaric hypoxia ( 180 Torr for 3 h ) and severe hypoxia preconditioned by intermittent mild hypoxia ( 360 Torr for 2 h daily , for 3 consecutive days , 24 h prior to severe hypoxia ) . ^^^ The preconditioning to severe hypoxia protected neurons from the posthypoxic apoptotic transformations , the up regulation of Bax expression , and resulted in persistent overexpression of Bcl 2 and Bcl xL . ^^^ We conclude that the protective action of hypoxic preconditioning is at least in part mediated by shifting of neuronal Bax / Bcl 2 Bcl xL ratio to a favor of antiapoptotic proteins Bcl 2 and Bcl xL . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
RESULTS : Etoposide treatment ( 1 ) induced apoptosis in one clone , ES , but not in another clone , ER , ( 2 ) had no effect on the expression of the antiapoptotic proteins Bcl 2 and Bcl 10 ( L ) in both cell clones , whereas the proapoptotic proteins Bak and Bax were dramatically upregulated in ES , but not ER cells , and ( 3 ) induced more extensive processing of procaspase 8 , procaspase 9 , and the caspase 3 targeted substrates , topoisomerase 1 and PARP , in ES cells . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Surgical injury affected the expression of apoptosis related genes Bcl 2 , Bax , Bcl xL and Bcl xS , inducing a mean 3 . 5 fold decrease in the Bcl 2 / Bax ratio and a 9 fold decrease in the Bcl xL / S ratio 4 h after injury as compared with uninjured carotid arteries . ^^^ The imbalance between proliferative stimulus represented by surgery and the c myc mRNA decrease induced greater apoptosis in AS ODN treated carotid arteries without further affecting mRNA levels of Bcl 2 , Bax , Bcl xL and Bcl xS genes . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Retroviral transduction of the sensitive parental cells with a dominant negative Trp 53 cDNA caused changes in the protein levels of p21Cip1 , BAX , and cleaved caspase 3 , but not bcl XL , and rendered the cells more resistant to Ara C . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
PAF increased the expression of mRNA and the protein synthesis of antiapoptotic factors , such as Bcl 2 and Bcl xL , but did not increase the expression of the proapoptotic factor , Bax . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
We investigated the role of the mitogen activated protein kinase ( MAPK ) signaling pathway ( ie , ERK1 / 2 ) and apoptosis regulating Bcl 2 family members ( ie , Bcl 10 ( L ) and Bax ) in the resolution of a rat carrageenan induced pleurisy model . ^^^ In conclusion , this study shows that ERK1 / 2 , Bax , and Bcl 10 ( L ) play important functional roles in the resolution phase of the acute inflammatory response in vivo by influencing apoptosis . ^^^ The involvement of the apoptosis modulating proteins ERK 1 / 2 , Bcl xL and Bax in the resolution of acute inflammation in vivo . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
This effect was associated with decreased Bcl xL : Bax ratio . ^^^ In contrast , wild type alsin was neuroprotective and increased Bcl xL : Bax ratio . ^^^ In addition , the identification of Bcl xL / Bax as target of protection by alsin and of cytotoxicity by the mutant form provides a new signalling event regulated by alsin protein that may be important to define its role in neuronal physiology and neurodegeneration . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Exposure to 5 azaC altered the expression of genes involved in imprinting ( IGF 2 ) or pro apoptosis ( BAX ) , whereas there was a reduction in the expression of the main enzyme responsible for replicating the DNA methylation pattern ( DNMT 1 ) and anti apoptosis ( BCL2L1 ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Interestingly , Bcl 2 / Bcl xL bispecific ASO treatment also resulted in the down regulation of Mcl 1 and up regulation of Bax . ^^^ Furthermore , the apoptotic induction by Bcl 2 / Bcl xL bispecific ASO was synergistically enhanced by siRNA mediated inhibition of clusterin , a cytoprotective chaperone that interacts with and inhibits activated Bax . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The proapoptotic proteins Bax and Bak are required for MOMP , while the antiapoptotic Bcl 2 proteins , including Bcl 2 , Bcl xL , Mcl 1 , and others , prevent MOMP . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The purpose of the present study was to analyse the effects of naltrexone on the expression levels of proteins regulating the extrinsic ( FasL and Fas ) and the mitochondrial ( Bcl 2 , Bcl xL , Bad and Bax ) apoptotic pathways , as well as the active fragment of the executioner caspase 3 in the mouse brain . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Inhibition of the intrinsic apoptosis pathway was suggested by decreases in the proapoptotic protein Bax and mitochondrial cytochrome c release , and an increase in the antiapoptotic protein Bcl 10 ( L ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Three groups of the Bcl 2 family proteins can be distinguished : the antiapoptotic proteins , like Bcl 2 and Bcl 10 L , the pro apoptotic members e . g . , Bax , Bak and the BH 3 only proteins . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Here we report the effects of BclX ( L ) and Bax over expression on stretch induced neural cell death using an in vitro uniaxial stretch model of traumatic axonal injury . ^^^ Specifically , YFP , YFP tagged Bax and YFP tagged BclX ( L ) proteins were expressed in differentiated NG 108 15 cells and stretch injury assays were carried out at different strain and strain rate combinations . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
A significantly increased activation of caspase 3 and 7 , decreased levels of antiapoptotic proteins Bcl 2 and Bcl 10 ( L ) , and increased levels of proapoptotic protein Bax was observed in the developing cerebral cortex of hypothyroid rats , compared with the euthyroid ( P < 0 . 001 ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
DNA fragmentation , mRNA and protein levels of Bcl XL , Bax and caspase 3 were determined to characterize interrelations between expression of these apoptotic markers in the neonatal brain regions . ^^^ High DNA fragmentation intensity in the cortex was in consonance with the lowest Bcl XL / Bax expression ratio , the highest procaspase 3 and active caspase 3 levels . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Radiation therapy induced changes in apoptosis and its major regulatory proteins , Bcl 2 , Bcl XL , and Bax , in locally advanced invasive squamous cell carcinoma of the cervix . ^^^ The major apoptotic regulatory molecules include Bcl 2 , Bcl XL ( antiapoptotic ) , and Bax ( proapoptotic ) proteins . ^^^ The TUNEL assay was performed to detect apoptotic nuclei and Bcl 2 , Bcl XL , and Bax proteins detected by immunohistochemistry ( IHC ) . ^^^ Bax , a major proapoptotic protein , was significantly increased following RT ( P < 0 . 05 ) , whereas the antiapoptotic Bcl XL showed a significant decrease ( P = 0 . 006 ) . ^^^ CONCLUSIONS : RT for invasive squamous cell carcinoma of cervix results in increased apoptotic cell death with the up regulation of Bax , a proapoptotic protein , and the down regulation of Bcl XL , an antiapoptotic protein , without any significant change in the levels of Bcl 2 . . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Reverse transcription polymerase chain reaction and immunoblotting results indicated that treatments of cells with beta lapachone resulted in down regulation of anti apoptotic Bcl 2 and Bcl 10 ( L ) and up regulation of pro apoptotic Bax expression . beta Lapachone induced apoptosis was associated with a proteolytic activation of caspase 3 and 9 and degradation of poly ( ADP ribose ) polymerase protein . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
RESULTS : At a 5 10 microM dose level , ( ) gossypol significantly enhanced apoptosis measured by DNA fragmentation . ( ) Gossypol caused apoptosis in DU 145 cells through the down regulation of Bcl 2 and Bcl xL and the up regulation of Bax at the mRNA and protein levels . ( ) Gossypol also activated caspases 3 , 8 and 9 and increased PARP [ poly ( ADP ribose ) polymerase ] cleavage . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The drug effects on the expression of the beta tubulin isotypes , Bcl 2 , Bax , Bcl XL and proteomic profiles were evaluated by immunobloting and SELDI mass spectrometry in tumor xenografts dosed at 0 . 5 MTDs . ^^^ The drugs had significantly different , yet highly heterogeneous effects on the tumor levels of betaI tubulin ( RH 30 ) , betaIII tubulin ( IMR 32 , KHOS / NP , RH ] ) , Bax ( IMR 32 , SK N MC ) and Bcl XL ( KHOS / NP ) . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The mRNA and protein levels of c Myc , Bcl 10 ( L ) and Bcl 2 were downregulated , whereas the expression of p 53 and bax was upregulated in mPER 2 overexpressing LLC cells compared with control cells transferred with empty plasmid . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Our results indicated that : ( 1 ) the hippocampus volume significantly increased from P 5 to P 60 , although the number of neurons remained stable in all studied stages ; ( 2 ) the number of apoptotic cells was highest at P 45 , based either on the Nissl staining or on the immunohistochemistry for caspase 3 ; ( 3 ) Bcl 2 mRNA expression was high from P 5 to adulthood , while Bax mRNA declined abruptly from P 5 to adulthood , and Bcl 10 mRNA was high after P 45 . ^^^ The expression levels of Bcl 2 family member mRNA and protein , including Bcl 2 , Bcl xL and Bax , were also investigated . ^^^ Bcl 2 protein was only detected at P 5 and P 15 , while detection of Bcl xL and Bax proteins paralleled levels of mRNA expression . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
However , the expressions of p 53 or pro or antiapoptotic Bcl 2 family proteins ( Bax , Bcl 2 , Bcl 10 ( L ) and Mcl 1 ) were not affected in any of the cell lines even after prolonged exposure to FB ( 1 ) at high doses . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Starting at 6 h , the apoptotic index increased in a time dependent manner , in correlation with the expression of HIF 1alpha , Bcl 2 , Bcl xL , Bax and cleaved Caspase 9 . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
These effects were accompanied by downregulation of proteins involved in anti apoptosis ( Bcl xL , XIAP or c IAP 2 ) and cell cycle progression ( cyclin D 1 ) , and induction of proteins involved in pro apoptosis ( Bax ) and cell cycle retardation ( p21Waf1 / Cip1 ) , although the degree of changes by DHMEQ was different in each hepatoma cell type . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
Its three factions of interacting proteins include the BH 3 only proteins ( e . g . , Bim , Puma , Bad , Noxa ) , which transduce diverse cytotoxic signals to the mammalian pro survival proteins ( Bcl 2 , Bcl 10 ( L ) , Bcl w , Mcl 1 , A 1 ) , whereas Bax and Bak , when freed from pro survival constraint , provoke the mitochondrial permeabilization that triggers apoptosis . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
The protein expression ratio of Bcl xL / Bax and Bcl 2 / Bax was down regulated and uncarinic acid E induced apoptosis involves the initial phase mediated by the balance among Bcl xL , Bcl 2 and Bax proteins , resulting in cytochrome c release from the mitochondria . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
EGF increased the expression of the Bcl 10 ( L ) protein , an antiapoptotic member of the Bcl 2 family , but not that of other anti ( Bcl 2 ) or proapoptotic ( Bad and Bax ) protein members . ^^^
Interacting proteins: Q07812 and Q07817	Pubmed	SVM Score :0.0
A mechanistic analysis demonstrated that CTX 3 induced apoptotic cell death was accompanied by up regulation of both Bax and endonuclease G ( Endo G ) , and downregulation of Bcl 10 ( L ) . ^^^ Up regulation of Bax and endonuclease G , and down modulation of Bcl XL involved in cardiotoxin 3 induced apoptosis in K 562 cells . ^^^ Modulation of Bax , Bcl XL , and the Endo G proteins , release of mitochondrial cytochome c , and activation of caspase 3 and 9 all are involved in the CTX 3 triggered apoptotic process in human leukemia K 562 cells . . ^^^