| Interacting proteins: Q07812 and P21796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07812 and P21796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07812 and P21796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07812 and P21796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07812 and P21796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07812 and P21796 |
Pubmed |
SVM Score :0.0 |
| The ANT preparations used were free of porin , cyclophilin D , and Bax as analysed immunologically and by activity measurements . ^^^ |
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| Interacting proteins: Q07812 and P21796 |
Pubmed |
SVM Score :0.0 |
| Here we create liposomes that carry the mitochondrial porin channel ( also called the voltage dependent anion channel , or VDAC ) to show that the recombinant pro apoptotic proteins Bax and Bak accelerate the opening of VDAC , whereas the anti apoptotic protein Bcl 10 ( L ) closes VDAC by binding to it directly . ^^^ |
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| Interacting proteins: Q07812 and P21796 |
Pubmed |
SVM Score :0.0 |
| Bax releases cytochrome c preferentially from a complex between porin and adenine nucleotide translocator . ^^^ This was shown by loading the vesicles with malate that was not liberated by Bax AC . ( 3 ) The Bax AC effect was dependent on a specific association of cytochrome c with the porin ANT complex , as dissociation of the complex by bongkrekate abolished the Bax dependent cytochrome c liberation . ( 4 ) The Bax AC effect was as well suppressed by hexokinase phosphorylating glucose . . ^^^ |
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| Interacting proteins: Q07812 and P21796 |
Pubmed |
SVM Score :0.0 |
| Colocalization of BAX with BID and VDAC 1 in nimesulide induced apoptosis of human colon adenocarcinoma COLO 205 cells . ^^^ In the present study the effect of nimesulide ( NIM ) , a specific COX 2 inhibitor , on apoptosis and interactions between BCL 2 family death promoters BAX and BID and BAX and VDAC 1 were examined in human colon adenocarcinoma COLO 205 cells . ^^^ This was accompanied by : ( 1 ) a decrease in intracellular prostaglandin ( PG ) E content ; ( 2 ) subcellular redistribution and aggregation of BAX and BID on organellar membranes and within the nucleus ; ( 3 ) colocalization of BAX with BID and BAX with VDAC 1 on organelles ; and ( 4 ) survival of cells with the highest BCL 2 aggregation . ^^^ A similar pattern of subcellular redistribution and colocalization of BAX with BID and BAX with VDAC 1 suggests that BAX ( in association with BID ) controls the function of VDAC 1 and its permeability for apoptogenic factors released from mitochondria of COLO 205 cells stimulated to apoptosis with NIM . . ^^^ |
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| Interacting proteins: Q07812 and P21796 |
Pubmed |
SVM Score :0.0 |
| Here we reported the biochemical evidence that both pro apoptotic Bax and anti apoptotic Bcl 10 ( L ) might simultaneously contact the putative loop regions of human VDAC 1 , and the existence of VDAC 1 Bax Bcl 10 ( L ) tertiary complex in vitro suggested that VDAC 1 channel conformation and mitochondrial permeability could be determined by the delicate balance between Bax and Bcl 10 ( L ) . . ^^^ |
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| Interacting proteins: Q07812 and P21796 |
Pubmed |
SVM Score :0.0 |
| Experiments with the use of double and triple immunolabelling visualized the colocalization of proapoptotic proteins such as Bax with Bid , Bax with Bid and voltage dependent anion channel protein ( VDAC 1 ) , and Bax with Bid and caspase 8 , on organellar membranes and within the nucleus . ^^^ Application of this technique in combination with EF EM technique augments our knowledge on the precise identification and relationship of subcellular structures containing Bax , Bid , VDAC 1 and caspase 8 . . ^^^ |
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| Interacting proteins: Q07812 and P21796 |
Pubmed |
SVM Score :0.0 |
| In the present study we used laser scanning cytometry , confocal microscopy and immunogold electron microscopy to analyze the expression , aggregation and co localization of caspase 8 , Bid , Bax and VDAC 1 . ^^^ Apoptosis in HC 11 mouse MEC manifested with a simultaneous increase in expression and subcellular aggregation of caspase 8 , Bid , Bax and VDAC 1 . ^^^ Experiments with double and triple staining immunoelectron microscopy showed a co localization of Bax / Bid , caspase 8 / Bax / Bid , and Bax / VDAC 1 , on the membranes of mitochondria , Golgi apparatus , rough endoplasmic reticulum , nuclear envelope , nuclear pore , and within the nucleus . ^^^ In conclusion , the observed pattern of changes in aggregation and subcellular localization of caspase 8 , Bid , Bax and VDAC 1 during TGF beta 1 induced apoptosis in HC 11 mouse MEC suggests an interaction between these proteins and formation of multimeric complexes on organellar membranes , thus controlling their permeability for intracellular mediators of apoptosis . . ^^^ |
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| Interacting proteins: Q07812 and P21796 |
Pubmed |
SVM Score :0.0 |
| This firstly hinders direct interaction between VDAC and ANT and secondly changes porin structure into low affinity for hexokinase and external Bax . ^^^ |
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| Interacting proteins: Q07812 and P21796 |
Pubmed |
SVM Score :0.0 |
| We also showed that GD 3 , the voltage dependent anion channel 1 ( VDAC 1 ) and the fission protein hFis 1 are structural components of a multimolecular signaling complex , in which Bcl 2 family proteins ( t Bid and Bax ) are recruited . ^^^ |
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