| Interacting proteins: Q07812 and O60936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07812 and O60936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07812 and O60936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07812 and O60936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07812 and O60936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07812 and O60936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07812 and O60936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07812 and O60936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07812 and O60936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07812 and O60936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07812 and O60936 |
Pubmed |
SVM Score :0.0 |
| No change in myc and bax expressions was observed in zinc treated SHE cells . . ^^^ |
|
| Interacting proteins: Q07812 and O60936 |
Pubmed |
SVM Score :0.0 |
| Northern blot experiments showed no significant difference in the expression of myc and bax apoptosis promoting genes in susceptible ( SP2 / 0 and D 5 ) and resistant ( P3X63 ) cell lines . ^^^ |
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| Interacting proteins: Q07812 and O60936 |
Pubmed |
SVM Score :0.0 |
| In mouse mammary tumors , the relative Bcl xL / Bax ratio was higher in TGF alpha / Myc double transgenics than in Myc single transgenics , in agreement with the in vitro data . ^^^ |
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| Interacting proteins: Q07812 and O60936 |
Pubmed |
SVM Score :0.0 |
| For example , apoptotic death depends on the balance of Fas , Fas ligand , nuclear factors ( eg , bcl 2 , bax , and myc ) , cytokines , neuropeptides , and cell membrane interactions with extracellular matrix . ^^^ |
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| Interacting proteins: Q07812 and O60936 |
Pubmed |
SVM Score :0.0 |
| In contrast , both cell types expressed equivalent levels of Bcl xL , Bax , Bcl 2 , Myc , retinoblastoma , p21cbor abl , and p145abl proteins . ^^^ |
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| Interacting proteins: Q07812 and O60936 |
Pubmed |
SVM Score :0.0 |
| For this , immunoblot analyses were performed to determine the expression of PGP , MRP , Myc , Bcl 2 , Bcl xL and Bax on either the multidrug resistant HL 60 sublines created under the selection pressure of doxorubicin ( HL 60 / AR ) , paclitaxel ( HL 60 / TAX1000 ) or vincristine ( HL 60 / VCR ) , or sublines created by transfection and overexpression of the bcl 2 ( HL 60 / Bcl 2 ) or bcl xL gene ( HL 60 / Bcl xL ) . ^^^ In addition , these multidrug resistant cells possess 1 . 5 to 2 . 5 fold higher Bcl 2 , while their Bax and Myc levels are similar to those in the control HL 60 cells . ^^^ |
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| Interacting proteins: Q07812 and O60936 |
Pubmed |
SVM Score :0.0 |
| For example , apoptotic death depends on the balance of Fas , Fas ligand , nuclear factors ( such as bcl 2 , bax , and myc ) , cytokines , neuropeptides , and cell membrane interactions with extracellular matrix . ^^^ |
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| Interacting proteins: Q07812 and O60936 |
Pubmed |
SVM Score :0.0 |
| Susceptibility to apoptosis measured by MYC , BCL 2 , and BAX expression in arterioles and capillaries of adult spontaneously hypertensive rats . ^^^ We analyzed the expression of c myc , bcl 2 , and bax and in situ end labeling DNA fragmentation in vascular smooth muscle cells of arterioles and endothelial cells of arterioles and capillaries . ^^^ Endothelial cells of capillaries and endothelial and smooth muscle cells of arterioles of hypertensive animals ( SHR ) express more Bax protein and Myc protein than their respective normotensive controls by margins that were statistically significant . ^^^ |
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| Interacting proteins: Q07812 and O60936 |
Pubmed |
SVM Score :0.0 |
| Myc potentiates apoptosis by stimulating Bax activity at the mitochondria . ^^^ During apoptosis , Bax translocation to the mitochondria occurs in the presence or absence of Myc expression . ^^^ Moreover , Bax mRNA and protein expression remain unchanged in the presence or absence of Myc . ^^^ However , in the absence of Myc , Bax is not activated and cytochrome c is not released into the cytoplasm . ^^^ Reintroduction of Myc into the c myc null cells restores Bax activation , cytochrome c release , and inhibition of apoptosis by Bcl 2 . ^^^ |
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| Interacting proteins: Q07812 and O60936 |
Pubmed |
SVM Score :0.0 |
| Bax loss impairs Myc induced apoptosis and circumvents the selection of p 53 mutations during Myc mediated lymphomagenesis . ^^^ Here we report that the proapoptotic Bcl 2 family member Bax also mediates apoptosis triggered by Myc and inhibits Myc induced lymphomagenesis . ^^^ Bax deficient primary pre B cells are resistant to the apoptotic effects of Myc , and Bax loss accelerates lymphoma development in E mu myc transgenics in a dose dependent fashion . ^^^ The absence of Bax did not alter the frequency of biallelic deletion of ARF in lymphomas arising in E mu myc transgenic mice or the rate of tumorigenesis in ARF null mice . ^^^ Strikingly , lymphomas from Bax null E mu myc transgenics lacked p 53 alterations , whereas 27 % of the tumors in Bax ( + / ) E mu myc transgenic mice contained p 53 mutations or deletions . ^^^ |
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| Interacting proteins: Q07812 and O60936 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To determine the role of apoptosis related proteins ( Myc , Bax , Bcl 2 , and Bcl 10 ( L ) ) in muscular damage in obstructed rat ureters . ^^^ The numbers of apoptotic cells in the smooth muscle layer correlated significantly with the expressions of Myc and Bax ( r = 0 . 7360 and 0 . 7432 , respectively ; both P < 0 . 005 ) , and with the expression index of Bax / Bcl 2 and Bax / Bcl 10 ( L ) ( r = 0 . 8909 and 0 . 8592 , respectively ; both P < 0 . 001 ) . ^^^ |
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| Interacting proteins: Q07812 and O60936 |
Pubmed |
SVM Score :0.0 |
| To elucidate the biochemical processes involved in the pathogenesis of B CLL and MCL , we analyzed the expression level of a set of genes that play central roles in apoptotic or cell proliferation pathways and of candidate genes from frequently altered genomic regions , namely ATM , BAX , BCL 2 , CCND 1 , CCND 3 , CDK 2 , CDK 4 , CDKN1A , CDKN1B , E2F1 , ETV 5 , MYC , RB 1 , SELL , TFDP 2 , TNFSF 10 , and TP 53 . ^^^ |
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| Interacting proteins: Q07812 and O60936 |
Pubmed |
SVM Score :0.0 |
| The expression of apoptosis related genes BCL 2 , BAX , BCL2L1 , BCL2A1 , MCL 1 , DAPK 1 and MYC was studied by quantitative real time polymerase chain reaction on total RNA samples from patients with acute lymphoblastic leukaemia ( ALL , n = 16 ) , acute myeloid leukaemia ( AML , n = 27 ) , chronic myeloid leukaemia ( CML , n = 12 ) , mantle cell lymphoma ( MCL , n = 19 ) and chronic lymphoid leukaemia ( CLL , n = 32 ) . ^^^ BCL 2 , BAX , BCL2A1 , MCL 1 , DAPK 1 and MYC were overexpressed in all patient groups . ^^^ |
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| Interacting proteins: Q07812 and O60936 |
Pubmed |
SVM Score :0.0 |
| In order to understand a possible involvement of genes regulating apoptotic signal pathways , expression levels of bcl 2 , bax , dapk 1 , myc , bad , wt 1 , and mcl genes were analyzed during ATRA treatment in five APL patients with t ( 15 ; 17 ) using Real time PCR ( LightCycler ) . ^^^ |
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| Interacting proteins: Q07812 and O60936 |
Pubmed |
SVM Score :0.0 |
| In addition , we report that ARC co immunoprecipitated with the pro apoptotic protein Bax , which causes cytochrome c release when activated . ^^^ TAT ARC , but not TAT ARCL31F , prevented Bax activation and cytochrome c release in hydrogen peroxide treated H9c2 cells . ^^^ In addition , recombinant ARC protein abrogated Bax induced cytochrome c release from isolated mitochondria . ^^^ This suggests that ARC can protect against cell death by interfering with activation of the mitochondrial death pathway through the interaction with Bax , preventing mitochondrial dysfunction and release of pro apoptotic factors . . ^^^ |
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| Interacting proteins: Q07812 and O60936 |
Pubmed |
SVM Score :0.0 |
| Novel genes involved in the regulation of apoptosis were found for the first time to be up regulated by gonadotrophin stimulation , including : BAX inhibitor 1 , granulysin and apoptosis repressor with caspase recruitment domain ( ARC ) . ^^^ |
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| Interacting proteins: Q07812 and O60936 |
Pubmed |
SVM Score :0.0 |
| Identification and characterization of their substrates indicate that they regulate the turnover of key cell cycle proteins ( p27Kip1 , p21Cip1 , p57Kip2 , cyclin E ) , tumor suppressor proteins ( p 53 , RB ) , signaling kinases ( Src , Zap 70 , PI 3 kinase ) , apoptosis regulators ( Bcl 2 , Bax , Bik ) and transcription factors ( Myc , NF kappaB , E1F1 ) , all of which have been implicated in the pathogenesis of malignant lymphoma . ^^^ |
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| Interacting proteins: Q07812 and O60936 |
Pubmed |
SVM Score :0.0 |
| The intrinsic pathway is antagonized by ARC Bax binding , involving ARC ' s CARD and the Bax C terminus . ^^^ Knockdown of endogenous ARC facilitates DISC assembly and triggers spontaneous Bax activation and apoptosis . ^^^ |
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| Interacting proteins: Q07812 and O60936 |
Pubmed |
SVM Score :0.0 |
| In the 6th and 8th week of intrauterine development we observed isolated TUNEL positive epithelial cells only and this was accompanied by the disperse presence of PCNA as well as by all the studied proteins : Bcl 2 , Bax , Bcl XL , c myc , N myc , p 53 , p 63 and p 73 . ^^^ The separation of primitive crypts and villi was not accompanied by any differences in distribution of Bax , Bcl XL , c myc , N myc , p 63 and p 73 proteins between those compartments : all the studied proteins showed dispersed character . ^^^ |
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| Interacting proteins: Q07812 and O60936 |
Pubmed |
SVM Score :0.0 |
| However , in cells lacking the gene c myc , membrane permeabilization by Bax is blocked by changes in the mitochondria that prevent Bax oligomerization . ^^^ Drug treated c myc null cells and cells expressing Myc were used to map the topology of Bax in membranes prior to and after mitochondrial permeabilization . ^^^ Additional topology changes for Bax were not required in Myc expressing cells to promote oligomerization and cytochrome c release . ^^^ |
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| Interacting proteins: Q07812 and O60936 |
Pubmed |
SVM Score :0.0 |
| Suppression of mtCLIC expression by RNA interference inhibited Myc induced apoptosis in response to different stress conditions and abolished the cooperative induction of apoptosis by Myc and Bax . ^^^ We also found that Myc reduces the expression of Bcl 2 and Bcl xL and that the apoptosis inducing stimuli up regulate Bax expression . ^^^ These results suggest that up regulation of mtCLIC , together with a reduction in Bcl 2 and Bcl xL , sensitizes Myc expressing cells to the proapoptotic action of Bax . . ^^^ |
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| Interacting proteins: Q07812 and O60936 |
Pubmed |
SVM Score :0.0 |
| Specific requirement for Bax , not Bak , in Myc induced apoptosis and tumor suppression in vivo . ^^^ Using a switchable mouse model of Myc induced apoptosis in pancreatic beta cells , we have shown that Myc induces apoptosis in vivo exclusively through Bax but not Bak . ^^^ Furthermore , blockade of Myc induced apoptosis by the inactivation of Bax , but not Bak , eliminates all restraints to the oncogenic potential of Myc , allowing the rapid and synchronous progression of invasive , angiogenic tumors . . ^^^ |
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| Interacting proteins: Q07812 and O60936 |
Pubmed |
SVM Score :0.0 |
| Overexpression of ARC inhibited oxidative stress induced caspase 2 / 3 activation , cytochrome c release , and translocation of Bax to mitochondria . ^^^ |
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