| Interacting proteins: Q07666 and P06493 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of the Src substrate Sam 68 by Cdc 2 during mitosis . ^^^ Cdc 2 was identified as the kinase responsible for the mitotic threonine phosphorylation by ( 1 ) immunodepletion of the mitotic Sam 68 kinase from cell lysates with anti Cdc 2 antibodies , ( 2 ) inhibition of Sam 68 phosphorylation in vitro and in vivo by the cyclin dependent kinase inhibitor olomoucine and ( 3 ) phosphorylation of Sam 68 by purified Cdc 2 . ^^^ These data demonstrate that Sam 68 is a direct target of Cdc 2 and may therefore mediate some of its biological effects during mitosis . . ^^^ |
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| Interacting proteins: Q07666 and P06493 |
Pubmed |
SVM Score :0.0 |
| The Sam 68 deficient cells exhibited markedly decreased growth and the growth retardation was due to elongation of the G 2 M phase , however , the kinase activity associated with Cdc 2 remained unaltered . ^^^ |
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| Interacting proteins: Q07666 and P06493 |
Pubmed |
SVM Score :0.0 |
| Sequencing of the partially enriched cDNAs identified 36 genes differentially expressed , including ECM proteins ( pro alpha ( 1 ) collagen type 3 , fibronectin ) , structural protein ( spectrin ) , enzyme ( GTP specific succinyl CoA synthetase ) , transcriptional regulators ( glucocorticoid induced leucine zipper , inhibitor of DNA binding 3 ) and proteins involved in cell division control ( cdc 2 ) or cell signalling ( insulin like growth factor binding protein 3 , mutant p 53 binding protein , grp 75 , CGI 121 , protein phosphatase type 2A , tspan 2 and Sam 68 ) . 4 . ^^^ |
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| Interacting proteins: Q07666 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
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