| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.66228882 |
| Using the highly invasive melanoma cell line BLM , we demonstrate that the chemokine Mig , a ligand for CXCR 3 , activates the small GTPases RhoA and Rac 1 , induces a reorganization of the actin cytoskeleton , and triggers cell chemotaxis and modulation of integrin VLA 5 and VLA 4 dependent cell adhesion to fibronectin . 0.66228882^^^ |
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| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| Tumor derived lymphocytes showed strong chemotactic responses to both CC and CXC chemokines in vitro and expressed high levels of CXCR 3 ( HuMig and IP 10 receptor ) and CCR 5 ( RANTES , MIP 1alpha , and MIP 1beta receptor ) . ^^^ |
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| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| The number of CXCR 3 ( MIG and IP 10 receptor ) positive lymphocytes ( Th 1 lymphocytes ) was not different between MIG and IP 10 positive and negative HD . ^^^ |
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| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| Mig is related functionally to interferon inducible protein 10 ( IP 10 ) , with which it shares a receptor , CXCR 3 . ^^^ |
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| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| Particularly important chemokines for activated / memory T cells are the CXCR 3 ligands IP 10 and Mig and the CCR 5 ligands RANTES , macrophage inflammatory protein 1alpha , and macrophage inflammatory protein 1beta . ^^^ |
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| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| This was confirmed by functional responses : only Th2s responded with an increase in [ Ca2+ ] 1 to the CCR 3 and CCR 4 agonists eotaxin and thymus and activation regulated chemokine ( TARC ) , whereas only Th0s and Th1s responded to low concentrations of the CXCR 3 agonists IFN gamma inducible protein 10 ( IP 10 ) and monokine induced by IFN gamma ( Mig ) . ^^^ |
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| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| The chemokine receptor CXCR 3 mediates rapid and shear resistant adhesion induction of effector T lymphocytes by the chemokines IP 10 and Mig . ^^^ We show that the chemokines 10 kDa inflammatory protein ( IP 10 ) and monokine induced by IFN ( Mig ) induce rapid and transient adhesion of human IL 2 stimulated T lymphocytes ( IL 2 T cells ) to immobilized integrin ligands through their receptor CXCR 3 , which is selectively expressed on activated T cells . ^^^ No effect was seen with resting naive / memory T cells which lack CXCR 3 and migration responses to IP 10 and Mig . ^^^ Under conditions of flow , IL 2 T cells roll and rapidly adhere to IP10 / Mig expressing HUVEC , and anti CXCR 3 mAb treatment reduces arrest and firm adhesion . ^^^ |
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| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| This novel chemokine , referred to as 1 TAC ( interferon inducible T cell alpha chemoattractant ) , is regulated by interferon ( IFN ) and has potent chemoattractant activity for interleukin ( IL ) 2 activated T cells , but not for freshly isolated unstimulated T cells , neutrophils , or monocytes . 1 TAC interacts selectively with CXCR 3 , which is the receptor for two other IFN inducible chemokines , the IFN gamma inducible 10 kD protein ( IP 10 ) and IFN gamma induced human monokine ( HuMig ) , but with a significantly higher affinity . ^^^ In addition , higher potency and efficacy of 1 TAC over IP 10 and HuMig is demonstrated by transient mobilization of intracellular calcium as well as chemotactic migration in both activated T cells and transfected cell lines expressing CXCR 3 . ^^^ |
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| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| CXCR 3 , an IP 10 / Mig receptor , was expressed on lymphocytic cells in virtually every perivascular inflammatory infiltrate in active MS lesions . ^^^ |
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| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| We therefore asked whether the CXC chemokines IFN induced protein of 10 kDa ( IP 10 ) , monokine induced by IFN gamma ( Mig ) , and IFN inducible T cell alpha chemoattractant ( 1 TAC ) , which specifically chemoattract activated T cells by signaling through the chemokine receptor CXCR 3 , were inducible in respiratory epithelial cells . ^^^ |
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| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| Monokine induced by IFN gamma ( MIG ) , IFN inducible T cell alpha chemoattractant ( 1 TAC ) , and IFN gamma inducible protein of 10 kDa ( IP 10 ) are related members of the CXC chemokine subfamily that bind to a common receptor , CXCR 3 , and that are produced by different cell types in response to IFN gamma . ^^^ Finally , supernatants harvested from stimulated PMN induced migration and rapid integrin dependent adhesion of CXCR 3 expressing lymphocytes ; these activities were significantly reduced by neutralizing anti MIG and anti IP 10 Abs , suggesting that they were mediated by MIG and IP 10 present in the supernatants . ^^^ |
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| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| Human IP 9 : A keratinocyte derived high affinity CXC chemokine ligand for the IP 10 / Mig receptor ( CXCR 3 ) . ^^^ By this approach we were able to isolate IP 10 and Mig , and in addition identified a novel highly potent ligand for the CXCR 3 receptor , designated interferon gamma inducible protein 9 , which proved to be chemotactic for activated T cells expressing CXCR 3 . ^^^ |
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| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| The migration elicited by IP 10 and Mig was inhibited by blocking CXCR 3 . ^^^ |
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| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| Increased intragraft expression of interferon y and the interferon gamma induced chemokines , inducible protein 10 and Mig , and infiltration by activated mononuclear cells expressing CXCR 3 , the receptor for inducible protein 10 and Mig , was also seen . ^^^ |
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| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| It was found that the CXCR 3 ligands , MIG and interferon gamma inducible protein 10 ( IP 10 ) , unlike SLC , did not induce chemotaxis of CD34+ HPC . ^^^ |
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| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| We now report the pharmacological characterization of CXCR 3 and find that , when heterologously expressed , CXCR 3 binds IP 10 and MIG with Ki values of 0 . 14 and 4 . 9 nM , respectively . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| Expression of CXCR 3 , the receptor for the CXC chemokines IFN gamma inducible 10 kDa protein ( IP 10 ) and monokine induced by IFN gamma ( Mig ) , in human T lymphocytes and their responses to IP 10 and Mig were analyzed . ^^^ Addition of chondroitin sulfate C to CXCR 3 expressing murine pre B cells allowed the determination of high affinity binding for Mig and IP 10 with Kd of 0 . 9 1 . 2 nM and 0 . 2 0 . 3 nM , respectively , and 1 . 3 10 10 ( 4 ) binding sites per cell . ^^^ |
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| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| The present study demonstrates the differential expression of the 3 IFN gamma inducible CXC chemokines IFN inducible protein 10 ( IP 10 ) , monokine induced by IFN gamma ( Mig ) , and IFN inducible T cell alpha chemoattractant ( 1 TAC ) by atheroma associated cells , as well as the expression of their receptor , CXCR 3 , by all T lymphocytes within human atherosclerotic lesions in situ . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| Transfection of murine CXCR 3 in murine pre B lymphocyte line ( CXCR3++ / L1 . 2 ) conferred binding of the ligands IP 10 , ITAC and Mig with K ( D ) ' s of 1 . 35 + / 0 . 56 , 1 . 41 + / 0 . 20 , and 11 . 65 + / 0 . 90 nM , respectively . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| Role for interactions between IP 10 / Mig and CXCR 3 in proliferative glomerulonephritis . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| The chemokine receptor CXCR 3 has been previously shown to be widely expressed on activated T cells and to mediate T cell chemotaxis on binding to various ligands , including Mig , IP 10 , and ITAC . ^^^ We also report that the CXCR 3 ligand , Mig , is coexpressed on tumor cells in many cases of CLL / SLL ( 10 of 13 cases examined ) with Mig expression less frequently seen in other B cell lymphoma subtypes . ^^^ Coexpression of CXCR 3 and its ligand , Mig , may be an important functional interaction in B CLL , as well as a useful diagnostic marker for the differential diagnosis of small cell lymphomas . ( Blood . 2000 ; 95 : 627 632 ) . ^^^ |
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| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| Expression of the interferon gamma inducible chemokines IP 10 and Mig and their receptor , CXCR 3 , in multiple sclerosis lesions . ^^^ Using immunocytochemistry , the expression of the alpha chemokines , interferon ( IFN ) gamma inducible protein 10 ( IP 10 ) and monokine induced by IFN gamma ( Mig ) , and their receptor CXCR 3 have been examined in post mortem central nervous system ( CNS ) tissue from MS cases at different stages of lesion development . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| Gamma interferon ( IFN gamma ) inducible protein 10 ( IP 10 ) and monokine induced by IFN gamma ( Mig ) are related CXC chemokines which bind to the CXCR 3 receptor and specifically target activated T lymphocytes and natural killer ( NK ) cells . ^^^ IP 10 and Mig may contribute to host defense in Th 1 mediated host defense during infections by attracting CXCR 3 ( + ) Th 1 cells to the site of inflammation . . ^^^ |
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| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| The CXCR 3 activating chemokines IP 10 , Mig , and IP 9 are expressed in allergic but not in irritant patch test reactions . ^^^ In the present study , we investigated whether the mRNA expression of IP 10 and the related CXCR 3 activating chemokines , Mig and IP 9 are also differentially expressed in human allergic contact dermatitis and irritant contact dermatitis reactions . ^^^ Results of chemokine mRNA expression were correlated with clinical scoring , histology , and immunohistochemical data including the proportion of inflammatory cells expressing CXCR 3 , the receptor for IP 10 , Mig , and IP 9 , and ICAM 1 and HLA DR expression on keratinocytes . ^^^ |
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| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| The chemokines Mig ( CXCR 3 ligand ) , TARC ( CCR 4 ligand ) , and MCP 2 ( CCR 5 ligand ) were detected in intratumoral blood vessels and histiocytes . ^^^ Mig was also coexpressed by a subset of CXCR 3 positive tumor cells in 6 of 20 lymphomas . ^^^ |
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| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| Moreover , we showed that CXCR 3 ligands , IP 10 and Mig , were able to activate ERK1 / 2 pathway in mouse cortical neurons , suggesting a novel mechanism of neuronal glial interaction . . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| IFN induced protein of 10 kDa ( IP 10 ) , monokine induced by IFN gamma ( Mig ) , and IFN inducible T cell alpha chemoattractant ( 1 TAC ) belong to the non glutamate leucine arginine motif CXC chemokine family and act solely through the CXCR 3 receptor for potent attraction of T lymphocytes . ^^^ In this study , we evaluated the capacity of the T cell derived cytokines IL 4 , IL 10 , and IL 17 to modulate IP 10 , Mig , and 1 TAC in cultured human keratinocytes and CXCR 3 expression in T cells from allergic contact dermatitis ( ACD ) . ^^^ |
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| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| CXC chemokine receptor 3 ( CXCR 3 ) , predominately expressed on memory / activated T lymphocytes , is a receptor for both IFN gamma inducible protein 10 ( gamma IP 10 ) and monokine induced by IFN gamma ( Mig ) . ^^^ We report a novel finding that CXCR 3 is also expressed on eosinophils . gamma IP 10 and Mig induce eosinophil chemotaxis via CXCR 3 , as documented by the fact that anti CXCR 3 mAb blocks gamma IP 10 and Mig induced eosinophil chemotaxis . gamma IP 10 and Mig induced eosinophil chemotaxis are up and down regulated by IL 2 and IL 10 , respectively . ^^^ Correspondingly , CXCR 3 protein and mRNA expressions in eosinophils are up and down regulated by IL 2 and IL 10 , respectively , as detected using flow cytometry , immunocytochemical assay , and a real time quantitative RT PCR technique . gamma IP 10 and Mig act eosinophils to induce chemotaxis via the cAMP dependent protein kinase A signaling pathways . ^^^ The fact that gamma IP 10 and Mig induce an increase in intracellular calcium in eosinophils confirms that CXCR 3 exists on eosinophils . ^^^ These results indicate that CXCR 3 gamma IP 10 and Mig receptor ligand pairs as well as the effects of IL 2 and IL 10 on them may be especially important in the cytokine / chemokine environment for the pathophysiologic events of allergic inflammation , including initiation , progression , and termination in the processes . . ^^^ |
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| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| Also , utilization of neutralizing antibodies to the CXCR 3 ligand Mig in murine allograft transplantation models has demonstrated the importance of CXCR 3 in orchestrating T cell mediated tissue rejection . . ^^^ |
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| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| Assessment of the functional capacity of CXCR 3 unexpectedly revealed that HMECs migrated in response to relatively higher concentrations ( 100 500 ng / ml ) of each of the ' angiostatic ' chemokines IP 10 , ITAC , and MIG . ^^^ |
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| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| Pulmonary T cells expressing CXCR 3 exhibited a high migratory capability in response to IP 10 and Mig . ^^^ |
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| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| Here we show that acute cardiac allograft rejection is accompanied by progressive intragraft production of the chemokines interferon ( IFN ) gamma inducible protein of 10 kD ( IP 10 ) , monokine induced by IFN gamma ( Mig ) , and IFN inducible T cell alpha chemoattractant ( 1 TAC ) , and by infiltration of activated T cells bearing the corresponding chemokine receptor , CXCR 3 . ^^^ |
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| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| CXC chemokine receptor 3 ( CXCR 3 ) , which is known to be expressed predominately on memory and activated T lymphocytes , is a receptor for both interferon gamma ( IFN gamma ) inducible protein 10 ( gamma IP 10 ) and monokine induced by IFN gamma ( Mig ) . ^^^ Freshly isolated CD 34 ( + ) progenitors expressed low levels of CXCR 3 messenger RNA , but this expression was highly up regulated by GM CSF , as indicated by a real time quantitative reverse transcriptase polymerase chain reaction technique . gamma IP 10 and Mig induced chemotaxis of GM CSF stimulated CD 34 ( + ) progenitors by means of CXCR 3 , since an anti CXCR 3 monoclonal antibody ( mAb ) was found to block gamma IP 10 induced and Mig induced CD 34 ( + ) progenitor chemotaxis . ^^^ These chemotactic attracted CD 34 ( + ) progenitors are colony forming units granulocyte macrophage . gamma IP 10 and Mig also induced GM CSF stimulated CD 34 ( + ) progenitor adhesion and aggregation by means of CXCR 3 , a finding confirmed by the observation that anti CXCR 3 mAb blocked these functions of gammaIP 10 and Mig but not of chemokine stromal cell derived factor 1 alpha . gamma IP 10 induced and Mig induced up regulation of integrins ( CD49a and CD49b ) was found to play a crucial role in adhesion of GM CSF stimulated CD 34 ( + ) progenitors . ^^^ Moreover , gamma IP 10 and Mig stimulated CXCR 3 redistribution and cellular polarization in GM CSF stimulated CD 34 ( + ) progenitors . ^^^ These results indicate that CXCR 3 gamma IP 10 and CXCR 3 Mig receptor ligand pairs , as well as the effects of GM CSF on them , may be especially important in the cytokine / chemokine environment for the physiologic and pathophysiologic events of differentiation of CD 34 ( + ) hematopoietic progenitors into lymphoid and myeloid stem cells , subsequently immune and inflammatory cells . ^^^ |
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| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| CXCR 3 , the receptor for 1 TAC ( interferon inducible T cell alpha chemoattractant ) , Mig ( monokine induced by gamma interferon ) , and IP 10 ( interferon inducible protein 10 ) , is expressed preferentially on Th 1 cells , whereas CCR 3 , the receptor for eotaxin and several other CC chemokines , is characteristic of Th 2 cells . ^^^ While studying responses that are mediated by these two receptors , we found that the agonists for CXCR 3 act as antagonists for CCR 3 . 1 TAC , Mig , and IP 10 compete for the binding of eotaxin to CCR 3 bearing cells and inhibit migration and Ca ( 2+ ) changes induced in such cells by stimulation with eotaxin , eotaxin 2 , MCP 2 ( monocyte chemottractant protein 2 ) , MCP 3 , MCP 4 , and RANTES ( regulated on activation normal T cell expressed and secreted ) . ^^^ |
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| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| IP 10 and Mig share a common functional receptor on activated T lymphocytes , named CXC chemokine receptor 3 ( CXCR 3 ) . ^^^ Both IP 10 and Mig , as well as the IFN gamma inducible T cell alpha chemoattractant ( 1 TAC ) , which all share high affinity binding for CXCR 3 , block HMVEC proliferation in vitro , an effect that can be inhibited by an anti CXCR 3 antibody . ^^^ |
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| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| Since chemokine receptors CXCR 3 and CCR 5 are preferentially expressed on Th 1 cells , we tested the expression and regulation of several chemokines , including those that signal through CXCR 3 ( interferon gamma inducible protein of 10 kDa , IP 10 , CXCL 10 ; and monokine induced by interferon gamma , Mig , CXCL 9 ) and CCR 5 ( macrophage inflammatory protein ( Mip ) 1 alpha , CCL 3 ; and Mip 1 beta , CCL 4 ) in RA synovial fluids , synovial tissues , and blood . ^^^ Chemokines , including IP 10 , Mig , Mip 1 alpha , and Mip 1 beta , may participate in the selective recruitment of CCR 5 ( + ) CXCR 3 ( + ) T cells to the inflamed synovium . . ^^^ |
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| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| Quantitative analysis of mRNA expression in the colons of IL 4 treated mice showed an up regulation of both Th 1 and Th 2 associated molecules , including IFN gamma , IP 10 , MIG , CXCR 3 , chemokine receptor 8 , and IL 4 . ^^^ |
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| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| RESULTS : IP 10 and Mig were constitutively expressed by normal human colon epithelium , and their cognate receptor , CXCR 3 , was expressed by mucosal mononuclear cells . ^^^ CONCLUSIONS : The constitutive and regulated production of the IFN gamma inducible chemokines IP 10 , Mig , and 1 TAC by human intestinal epithelium , and the expression of their cognate receptor , CXCR 3 , by mucosal mononuclear cells , suggest that the intestinal epithelium can play a role in modulating physiologic and pathologic T cell mediated mucosal inflammation . . ^^^ |
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| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| We have shown that two other ligands of CXCR 3 , IP 10 and MIG , are potent inhibitors of tumor growth in severe combined immunodeficiency ( SCID ) mice . ^^^ |
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| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| The human CXC chemokines IP 10 ( 10 kDa interferon inducible protein ) , MIG ( monokine induced by human interferon gamma ) , and 1 TAC ( interferon inducible T cell alpha chemoattractant ) attract lymphocytes through activation of CXCR 3 . ^^^ |
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| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| Serial analysis of allografts showed that intragraft expression of the three chemokine ligands for the CXC chemo kine receptor CXCR 3 was induced in the order of interferon ( IFN ) gamma inducible protein of 10 kD ( IP 10 , or CXCL 10 ) , IFN inducible T cell alpha chemoattractant ( 1 TAC ; CXCL 11 ) , and then monokine induced by IFN gamma ( Mig , CXCL 9 ) . ^^^ |
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| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| CXCR 3 and CCR 4 were expressed by dermal CD3+ lymphocytes , and their chemokine ligands , IP 10 , MIG , TARC , and MDC , were up regulated in psoriatic lesions . ^^^ |
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| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| Finally , CCR 3 expression by CD4+ / CD45RO+ T cells was positively correlated with plasma levels of its ligand , eotaxin , whereas strong negative correlations were evident between CXCR 3 expression and IP 10 or Mig . ^^^ |
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| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| Here , the biological activity and expression patterns of murine CXCL 11 relative to CXCL 9 ( MIG ) and CXCL 10 ( IP 10 / crg 2 ) , the other two CXCR 3 ligands , were assessed . ^^^ Calcium mobilization and chemotaxis experiments demonstrated that murine CXCL 11 stimulated murine CXCR 3 at much lower doses than murine CXCL 9 or murine CXCL 10 . ^^^ |
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| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| Differential expression of CXCR 3 targeting chemokines CXCL 10 , CXCL 9 , and CXCL 11 in different types of skin inflammation . ^^^ As CXCR 3 activating chemokines CXCL 10 ( IP 10 ) , CXCL 9 ( Mig ) , and CXCL 11 ( IP 9 / I TAC ) specifically attract activated T cells , this study addressed the question of whether differences in the expression of these chemokines correlate with the site and cellular composition of the skin infiltrates in different types of inflammatory skin disease . ^^^ |
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| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| At the time of rejection in Mig antiserum treated recipients ( i . e . , days 17 19 ) , intra allograft expression of macrophage inflammatory protein 1alpha , 1beta , and their ligand CCR 5 was high , whereas expression of CXCR 3 , the Mig receptor , was virtually absent . ^^^ |
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| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| CXCR 3 , known to have four ligands ( IFN gamma inducible protein 10 ( gamma IP 10 ) , monokine induced by IFN gamma ( Mig ) , 1 TAC , and 6Ckine ) , is predominantly expressed on memory / activated T lymphocytes . ^^^ We recently reported that GM CSF induces CXCR 3 expression on CD 34 ( + ) hemopoietic progenitors , in which gamma IP 10 and Mig induce chemotaxis and adhesion . ^^^ Thus , GM CSF binds to its receptor CD 116 , and consequently activates Syk phosphorylation , which leads to induce CXCR 3 expression . gamma IP 10 and Mig can induce Syk , Cbl , and Cbl b phosphorylation in CD 34 ( + ) progenitors by means of CXCR 3 . gamma IP 10 or Mig has induced neither chemotaxis nor adhesion in GM CSF stimulated Cbl b blocked CD 34 ( + ) hemopoietic progenitors , whereas SDF 1alpha induces both chemotaxis and adhesion in these cells . ^^^ |
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| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| T lymphoblasts expressing CXCR 3 showed an increased migration to supernatants from stimulated TFCs , which was abolished by specific antibodies to the chemokines Ip 10 and Mig , as well as to their receptor CXCR 3 . ^^^ |
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| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| The CXC chemokines ( monokine induced by IFN gamma ( MIG ) / CXC chemokine ligand ( CXCL ) 9 , IP 10 / CXCL10 , and IFN inducible T cell alpha chemoattractant ( ITAC ) / CXCL11 ) act through their shared receptor , CXCR 3 . ^^^ Translational studies in a murine model demonstrated increased expression of MIG / CXCL9 , IP 10 / CXCL10 , and ITAC / CXCL11 paralleling the recruitment of CXCR 3 expressing mononuclear cells . ^^^ In vivo neutralization of CXCR 3 or its ligands MIG / CXCL9 and IP 10 / CXCL10 decreased intragraft recruitment of CXCR 3 expressing mononuclear cells and attenuated BOS . ^^^ |
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| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| Monokine induced by IFN gamma ( Mig ; CXC chemokine ligand 9 ) is an IFN gamma inducible CXC chemokine that signals through the receptor CXCR 3 and is known to function as a chemotactic factor for human T cells , particularly following T cell activation . ^^^ We have investigated the expression and activities of Mig and CXCR 3 in mouse cells and the role of Mig in models of host defense in mice . ^^^ Together , our data suggest that Mig and CXCR 3 may be important not only to recruit T cells to peripheral inflammatory sites , but also in some cases to maximize interactions among activated T cells , B cells , and dendritic cells within lymphoid organs to provide optimal humoral responses to pathogens . . ^^^ |
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| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| Therefore , we investigated expression of IFN inducible protein 10 ( IP 10 ) , IFN inducible T cell alpha chemoattractant ( 1 TAC ) , monokine induced by IFN ( Mig ) , and their receptor CXCR 3 in consecutive endomyocardial biopsies ( n = 133 ) from human cardiac allografts and corresponding normal donor hearts ( n = 11 ) before transplantation . ^^^ |
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| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| We therefore characterized constitutive and regulated epithelial expression of the CXC chemokines IP 10 , 1 TAC and Mig , which specifically attract CXCR 3 expressing CD 4 ( + ) T cells . ^^^ |
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| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| The interferon ( IFN ) inducible chemokines , specifically , IFN gamma inducible protein 10 ( IP 10 ) , monokine induced by IFN gamma ( Mig ) , and IFN inducible T cell alpha chemoattractant ( 1 TAC ) , share a unique CXC chemokine receptor ( CXCR 3 ) . ^^^ These data demonstrate a negative feedback regulation by CD26 / DPP 4 in CXCR 3 mediated chemotaxis without affecting the angiostatic potential of the CXCR 3 ligands IP 10 and Mig . . ^^^ |
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| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| Using neutralizing mAbs to IFN induced protein 10 ( CXCL 10 ) , monokine induced by IFN gamma ( CXCL 9 ) , and IFN inducible T cell alpha chemoattractant ( 1 TAC ; CXCL 11 ) , we found that even though 1 TAC was secreted from IFN gamma activated HSVEC to lower levels than IFN induced protein 10 or the monokine induced by IFN gamma , it was the principal chemokine responsible for CXCR 3 internalization . ^^^ |
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| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| We detected constitutive expression of the MIG receptor , CXCR 3 , on the surface of the endothelial cells and therefore hypothesize that it plays a role in maintaining the cytokine gradient at the region of CNS inflammation . . ^^^ |
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| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| In addition , IFN gamma positive lymphocytes were frequently detected in the surrounding dead tissue , and the lymphocytes in the same area were frequently positive for CXCR 3 , a specific receptor of MIG and IP 10 . ^^^ |
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| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| Mig , IP 10 , and CXCR 3 gene expression is predictive for the individual response of children with chronic allograft nephropathy to mycophenolate mofetil . ^^^ |
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| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| Structure function relationship between the human chemokine receptor CXCR 3 and its ligands . 1 TAC , IP 10 , and Mig are interferon gamma inducible CXC chemokines that share the same G protein coupled receptor CXCR 3 , which is preferentially expressed on Th 1 lymphocytes . ^^^ A potent antagonist for CXCR 3 was obtained by NH ( 2 ) terminal truncation of 1 TAC . 1 TAC ( 4 73 ) , which lacks the first three residues , has no agonistic activity but competes for the binding of 1 TAC to CXCR 3 bearing cells and inhibits migration and Ca ( 2+ ) changes in such cells in response to stimulation with 1 TAC , IP 10 , and Mig . ^^^ |
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| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| Of note was the marked expression of both CXCR 3 and its ligand Mig on endothelial cells from portal neovessels in chronic hepatitis C . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| The expression of interferon ( IFN ) gamma inducible protein ( IP ) 10 , monokine induced by IFN gamma ( Mig ) , interferon inducible T cell alpha chemoattractant ( 1 TAC ) , regulated on activation normal T cell expressed and secreted ( RANTES ) , monocyte chemotactic protein ( MCP ) 1 , interleukin ( IL ) 8 , and the receptors CXCR 3 and CCR 5 were tested using quantitative , real time polymerase chain reaction . ^^^ RESULTS : Expression of IP 10 , Mig , 1 TAC , RANTES , CXCR 3 , and CCR 5 , but not MCP 1 and IL 8 , increased significantly in both grade 2 and grade 3 rejection ( P < / =0 . 0096 ) . ^^^ CONCLUSION : The expression of IP 10 , Mig , 1 TAC , RANTES , CXCR 3 , and CCR 5 in cardiac allografts significantly correlates with the presence and grade of acute rejection . . ^^^ |
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| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| The IP 10 and MIG receptor CXCR 3 was detected in the bronchiolar epithelium of preterm lambs by immunostaining . ^^^ |
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| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| Expression of chemokine receptor CXCR 3 and its ligand , mig , in gastric and thyroid marginal zone lymphomas . ^^^ Our study was designed to investigate the expression of CXCR 3 and its ligand Mig , and their relationships in MALT using immunohistochemistry . ^^^ In double staining , CXCR 3 Mig coexpressing lymphoma cells were abundant in high MALT of the stomach and thyroid , but rare in other subtypes . ^^^ Our results indicate a tendency for low grade MALT to contain CXCR 3 ( + ) Mig lymphoma cells , high grade to contain CXCR 3 ( + ) Mig+ and DL to contain CRCR 3 ( ) Mig lymphoma cells . ^^^ |
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| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| In contrast to CXCR 4 , the expression levels of the chemokine receptor CXCR 3 and the migration of cells in response to CXCL 9 and CXCL 10 increased after IL 2 treatment . ^^^ |
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| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| The chemokines CXCL 9 , 10 , and 11 exert their action via CXC chemokine receptor 3 ( CXCR 3 ) , a receptor highly expressed on activated T cells . ^^^ |
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| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| Human microvascular endothelial cell line 1 ( HMEC 1 ) , transfected with either the known CXCR 3 ( renamed CXCR 3 A ) or CXCR 3 B , bound CXCL 9 , CXCL 10 , and CXCL 11 , whereas CXCL 4 showed high affinity only for CXCR 3 B . ^^^ Remarkably , primary cultures of human microvascular endothelial cells , whose growth is inhibited by CXCL 9 , CXCL 10 , CXCL 11 , and CXCL 4 , expressed CXCR 3 B , but not CXCR 3 A . ^^^ An alternatively spliced variant of CXCR 3 mediates the inhibition of endothelial cell growth induced by IP 10 , Mig , and 1 TAC , and acts as functional receptor for platelet factor 4 . ^^^ |
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| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| Expression of CD 4 , CD8alpha , CD 40 , CD 86 , CD 28 , CD 31 and vascular endothelial growth factor was not different between the two tumor groups but expression of CD 40 ligand , CD 80 , NK1 . 1 and CXCR 3 was relatively lower in A11 / Mig tumors . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| This review discusses chemokine responses in relation to HSV infection of the cornea emphasizing the role of CXCR 3 chemokine signaling by the IFN gamma inducible ligands MIG , IP 10 and 1 TAC and includes discussion of their potential role in immunopathology in the nervous system . . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| METHODS : Expression of inducible protein ( IP ) 10 , monokine induced by IFN gamma ( Mig ) , interferon inducible T cell alpha chemoattractant ( 1 TAC ) , regulated on activation normal T cell expressed and secreted ( RANTES ) , and their receptors CXCR 3 and CCR 5 was tested in 60 endomyocardial biopsies from 24 patients using quantitative ( Taqman ) real time polymerase chain reaction ( PCR ) . ^^^ RESULTS : IP 10 , Mig , RANTES , CXCR 3 , and CCR 5 expression levels were increased in the later versus earlier biopsies ( P < or =0 . 01 ) despite no change in histologic rejection grade status . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| CCR 3 functional responses are regulated by both CXCR 3 and its ligands CXCL 9 , CXCL 10 and CXCL 11 . ^^^ The chemokine receptor CXCR 3 is predominantly expressed on T lymphocytes , and its agonists CXCL 9 , CXCL 10 and CXCL 11 are IFN gamma inducible chemokines that promote Th 1 responses . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| Most of the CD3+ infiltrating lymphocytes in dense periductal foci expressed CXCR 3 , the receptor for IP 10 and Mig . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| Immunohistologic analysis of human renal transplant biopsies showed expression of inducible costimulator ( ICOS ) , the chemokine receptor CXCR 3 , and its ligands , Mig and IP 10 , by intraglomerular and periglomerular leukocytes in biopsies with CAN and TGP but not CAN alone . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| The expression of the CXCR 3 ligands CXCL 9 and CXCL 10 was significantly higher than the other chemokines investigated . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| The PMN mediated regulation of granuloma formation depended on chemokines signaling through CXCR 3 , in particular MIG , as indicated by immune histochemical analysis of lung sections from C57BL / 6 wild type and CXCR 3 ( / ) mutant mice and supported by microarray transcriptome analysis . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| CXCR 3 is a chemokine receptor predominantly expressed on T lymphocytes , and binds the chemokines CXCL 9 ( Mig ) , CXCL 10 ( IP 10 ) and CXCL 11 ( 1 TAC ) . ^^^ In contrast , the N terminus and first extracellular loop of CXCR 3 play some role in CXCL 10 and CXCL 11 mediated activation but are dispensable for CXCL 9 induced signaling . ^^^ The third extracellular loop of CXCR 3 is important only for CXCL 9 and CXCL 10 induced chemotaxis . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| The ELR negative CXC chemokines CXCL 9 , CXCL 10 , and CXCL 11 ) are potent chemoattractants for mononuclear cells and act through their shared receptor , CXCR 3 . ^^^ We performed studies in a rat orthotopic lung transplantation model of acute rejection , and demonstrated increased expression of CXCL 9 and CXCL 10 paralleling the recruitment of mononuclear cells and cells expressing CXCR 3 to the allograft . ^^^ Inhibition of CXCL 9 decreased intragraft recruitment of mononuclear cells and cellular expression of CXCR 3 , resulting in lower acute lung allograft rejection scores . ^^^ This supports the notion that CXCL 9 interaction with cells expressing CXCR 3 has an important role in the recruitment of mononuclear cells , a pivotal event in the pathogenesis of acute lung allograft rejection . . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| High CXCR 3 expression in synovial mast cells associated with CXCL 9 and CXCL 10 expression in inflammatory synovial tissues of patients with rheumatoid arthritis . ^^^ These findings suggest that substantial expression of CXCR 3 protein on mast cells within synovial tissue from RA patients plays a significant role in the pathophysiology of RA , accompanied by elevated levels of the chemokines CXCL 9 and CXCL 10 . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| In addition , the relative roles of the chemokines that bind CXCR 3 ( CXCL 9 , CXCL 10 , CXCL 11 ) and CCR 5 ( CCL 3 , CCL 4 , CCL 5 ) in this process are unknown . ^^^ T lymphoblasts migrated in vitro to CXCR 3 ligands with a relative potency of CXCL 10 > CXCL 11 > CXCL 9 , but these cells demonstrated much less chemotaxis to the CCR 5 ligands . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| Because IFN gamma inducible chemokines , Mig ( CXCL 9 ) , IP 10 ( CXCL 10 ) , 1 TAC ( CXCL 11 ) and their receptor , CXCR 3 , are critical molecules in T cell trafficking and generation of effector T cells , we examined their expression in the muscle biopsies of patients with sporadic inclusion body myositis ( s IBM ) and disease controls . ^^^ By double label immunohistochemistry , Mig was expressed on a subset of CD 8 ( + ) cells and the areas of the muscle fiber in contact or contiguous to the T cells ; CXCR 3 was expressed only on a subset of the autoinvasive CD 8 ( + ) T cells but not the myofibers . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| PURPOSE : To examine the expression of the three interferon gamma inducible CXCR 3 binding chemokines , CXCL10 / IP 10 ( interferon gamma inducible protein of 10 KDa ) , CXCL9 / Mig ( monokine induced by interferon gamma ) , and CXCL11 / I TAC ( interferon inducible T cell alpha chemoattractant ) in the conjunctiva of patients with vernal keratoconjunctivitis ( VKC ) . ^^^ CONCLUSIONS : The CXC chemokine Mig is selectively and highly expressed in VKC suggesting a pathogenic role of the chemokine receptor CXCR 3 and the ligand Mig in the recruitment of activated T lymphocytes . . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| Among the potent Th 1 type chemokines inhibited were the CXCR 3 ligands CXCL 9 and CXCL 10 , which could directly inhibit vector mediated gene expression in myoblasts , although targeting CXCR 3 or its ligands did not prolong allograft survival with vIL 10 gene transfer . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| Among CXCR 3 chemokines , IFN gamma inducible protein of 10 kDa ( CXC chemokine ligand ( CXCL ) 10 ) but not monokine induced by IFN gamma ( CXCL 9 ) imprints a pattern for the subsequent development of autoimmune disease . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| We now show that islet allograft rejection is associated with a steady increase in intragraft expression of the chemokines CCL 8 ( monocyte chemoattractant protein 2 ) , CCL 9 ( monocyte chemoattractant protein 5 ) , CCL 5 ( RANTES ) , CXCL 10 ( IFN gamma inducible protein 10 ) , and CXCL 9 ( monokine induced by IFN gamma ) and their corresponding chemokine receptors CCR 2 , CCR 5 , CCR 1 , and CXCR 3 . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| Monokine induced by IFN gamma ( MIG ) , IFN gamma inducible T cell alpha chemoattractant ( 1 TAC ) , and IFN gamma inducible protein 10 ( IP 10 ) , are chemokines that bind CXCR 3 and mediate the chemotaxis of leukocytes . ^^^ IP 10 , MIG , and CXCR 3 have been shown to be expressed at sites of CD . ^^^ To better understand the role of CXCR 3 interactions during CD , we characterized the effects of IP 10 , MIG , 1 TAC , and CXCR3+ T cells on mucosal immune responses . ^^^ Taken together , these studies suggest that IP 10 , MIG , 1 TAC , and CXCR 3 interactions are involved in mucosal immune responses required for the induction of CD . . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| The effects of two regulatory cytokines , TNFalpha and IFNgamma , on the expression of CD 54 ( ICAM 1 ) and CD 106 ( VCAM 1 ) adhesion molecules and the CXCR 3 ligands ( CXCL 9 , CXCL 10 , CXCL 11 ) , were assessed in a primary culture of human OB by real time PCR , flow cytometry , and immunohistochemistry . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| Unexpectedly , the allergen challenged lung ( a T helper 2 microenvironment ) was found to be associated with the expression of T helper 1 associated CXCR 3 ligands , monokine induced by IFN gamma ( Mig ) , and IFN gamma inducible protein of 10 kDa ( IP 10 ) . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| Synergistic induction of CXCL 9 and CXCL 11 by Toll like receptor ligands and interferon gamma in fibroblasts correlates with elevated levels of CXCR 3 ligands in septic arthritis synovial fluids . ^^^ Enhanced levels of the CXC chemokine ligand ( CXCL 9 ) / monokine induced by interferon gamma ( IFN gamma ) and CXCL11 / IFN inducible T cell alpha chemoattractant , two chemoattractants for activated T cells and natural killer cells , and ligands for CXC chemokine receptor 3 ( CXCR 3 ) were detected in the synovial fluid of septic arthritis compared with osteo and crystal arthritis patients . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| In this study , we investigated the production of the CXCR 3 agonistic chemokines CXCL 9 , CXCL 10 , and CXCL 11 by synovial tissue cells and synovial fibroblast cell lines ( fourth or fifth passage ) from RA patients . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| The CXC chemokines 1 TAC , Mig and IP 10 and their receptor CXCR 3 are associated with advanced stage tumor and contribute to tumor progression , invasion and metastasis . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| Rat recombinant Mig displayed chemotactic properties and induced CXCR 3 internalization in CD4+ T cells . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| Expression of CXCR 3 ligands , such as monokine induced by IFN gamma ( Mig ) leads to preferential Th 1 recruitment , whereas CCR 4 ligands , thymus and activation regulated chemokine ( TARC ) or macrophage derived chemokine ( MDC ) , mediate preferential Th 2 recruitment . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| In this study , we investigated the expression of ligands for CXCR 3 ( Mig , IP 10 , and 1 TAC ) and CXCR 4 ( SDF 1 ) in the human endometrium throughout the menstrual cycle . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| Serum interleukin ( IL ) 12 and IFN gamma and the expression of IFN gamma inducible chemokines IP 10 , Mig and their receptor CXCR 3 in peripheral cells were analyzed . ^^^ An enhanced expression of IFN gamma chemokines IP 10 , Mig and CXCR 3 in patients with stable angina was also observed . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| Importantly , such a stimulation of metastasis was largely suppressed when CXCR 3 expression in B16F10 cells was reduced by antisense RNA or when mice were treated with specific antibodies against CXCL 9 and CXCL 10 . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| The selective CXC chemokine receptor 3 ( CXCR 3 ) agonists , monokine induced by interferon gamma ( IFN gamma ) / CXC chemokine ligand 9 ( CXCL 9 ) , IFN inducible protein 10 / CXCL10 , and IFN inducible T cell alpha chemoattractant ( 1 TAC ) / CXCL11 , attract CXCR3+ cells such as CD45RO+ T lymphocytes , B cells , and natural killer cells . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| Regulation of cockroach antigen induced allergic airway hyperreactivity by the CXCR 3 ligand CXCL 9 . ^^^ The CXCR 3 ligands , CXCL 9 ( monokine induced by IFN gamma ) and CXCL 10 ( IFN inducible protein , 10 kDa ) , are IFN gamma inducible , Th 1 type chemokines . ^^^ Taken together , our results demonstrate that the CXCR 3 ligand CXCL 9 is involved in regulation of the allergic response in the lung by regulation of lymphocyte activation and eosinophil recruitment . . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| CXCL 11 ( ITAC ) is one of three chemokines known to bind the receptor CXCR 3 , the two others being CXCL 9 ( Mig ) and CXCL 10 ( IP 10 ) . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| We found both in skin lesions and in invaded lymph nodes an expression by tumor cells of CXCR 3 , CXCR 4 , and CCR 7 , and the concomitant expression by cells in the microenvironment of their respective ligands CXCL 9 , CXCL 12 , and CCL 19 . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| From the gene expression profiling , CCR 4 , CCR 3 , MIG , CXCR 3 and BLC were selected for immunohistochemistry . ^^^ ALCL ( n=26 ) expressed CCR 3 , NKL ( n=20 ) expressed MIG , and AILD ( n=29 ) expressed CXCR 3 and / or BLC . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| Most impressively , mRNA for CXCR 3 , the receptor for CXCL 9 and CXCL 10 , was massively up regulated in the lungs of SARS CoV infected mice . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| Renal biopsies were examined by immunohistochemical staining for CXCR 3 and Mig . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| T lymphocytes are the most important effectors of immunity , and the CXCR 3 ligands CXCL 9 and CXCL 10 may play an important role in the T cell mediated clearance of rickettsiae from the infected vasculature as suggested by recent expression studies . ^^^ Here we showed that antibody mediated neutralization of CXCL 9 and CXCL 10 , and CXCR 3 gene knockout , had no effect on survival or bacterial loads of mice infected with rickettsiae . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| The authors examined expression of 1 TAC , Mig , and their receptor , CXCR 3 , in tissue samples from patients with renal cell carcinoma ( RCC ) . ^^^ The expression levels of 1 TAC , Mig , and CXCR 3 were investigated using reverse transcriptase polymerase chain reaction ( RT PCR ) analysis , real time RT PCR analysis , and Western blot analysis . ^^^ RESULTS : RT PCR analysis showed strong expression levels of 1 TAC , Mig , and CXCR 3 in RCC tissues and very weak or undetectable expression in normal kidney tissues . ^^^ Real time RT PCR analysis showed that expression levels of 1 TAC , Mig , and CXCR 3 in RCC tissues were 14 . 9 times greater , 30 . 3 times greater , and 9 . 9 times greater compared with the levels in the corresponding normal kidney tissues , respectively ( P < 0 . 01 ) . ^^^ Western blot analysis showed up regulation of 1 TAC , Mig , and CXCR 3 at the protein level . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| MIG secreted on RANKL treatment could stimulate the migration and adhesion of osteoclast precursors and osteoclasts that were primed to express CXCR 3 , the MIG receptor , by macrophage colony stimulating factor ( M CSF ) . ^^^ Therefore , we provide the first evidence demonstrating that RANKL stimulates the serine phosphorylation of STAT 1 through the p 38 MAPK pathway , causing MIG gene transcription and secretion , which may have a role in recruiting CXCR 3 positive osteoclast precursors and osteoclasts to bone remodeling or inflammatory sites . . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| CXCR 3 , IP 10 , and Mig are required for CD4+ T cell recruitment during the DTH response to HSV 1 yet are independent of the mechanism for viral clearance . ^^^ CXCR 3 ligands IP 10 and Mig were elevated at the DTH site . ^^^ Furthermore , CXCR 3 ligand expression was abrogated and DTH diminished in mice unable to make IFN gamma , a potent inducer of IP 10 and Mig . ^^^ Collectively , these results suggest that in the sensitized host , CXCR 3 , IP 10 , and Mig are required for optimal DTH responsiveness but are not essential for containing HSV 1 replication in the ear pinna . . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| The three CXCR 3 ligands CXCL 9 , CXCL 10 , and CXCL 11 are produced at sites of inflammation and elicit migration of pathological Th 1 cells . ^^^ There was a striking difference in potencies among the three CXCR 3 ligands , with CXCL 11 > > CXCL 10 > CXCL 9 . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| Bronchoscopic PPD challenge of skin test positive subjects resulted in the production of CXCR 3 ligands IFN gamma inducible protein ( IP ) 10 and monokine induced by IFN gamma ( Mig ) , but not of CCR 5 ligands macrophage inflammatory protein 1alpha and regulated upon activation , normal T cell expressed and secreted , whereas skin test negative subjects produced none of these chemokines . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| The chemokines ( CXCL 9 , CXCL 10 and CXCL 11 ) and associated CXCR 3 receptor are expressed during the inflammatory process from multiple sclerosis , atherosclerosis or organ transplantation resulting in the recruitment of lymphocytes leading to tissue damage . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| In this study , we evaluated the roles of the chemokines MIG ( CXCL 9 ) , IP 10 ( CXCL 10 ) , and 1 TAC ( CXCL 11 ) and their common receptor , CXCR 3 . ^^^ Induced MIG , IP 10 , and 1 TAC protein expression was localized in areas of inflammation at 2 to 3 days and was temporally associated with increased levels of CXCR 3 ( + ) lymphocytes in bronchoalveolar lavage fluid . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| CXCR 3 positive B cells found at elevated frequency in the peripheral blood of patients with MALT lymphoma are attracted by MIG and belong to the lymphoma clone . ^^^ In MALT cases , CXCR 3 positive B lymphocytes in PB could migrate to MIG , the CXCR 3 ligand . ^^^ Immunohistochemical analysis showed that MALT lymphoma cells expressed CXCR 3 , whereas epithelial glands and / or stromal cells expressed MIG . ^^^ The findings support the theory that CXCR 3 positive B lymphocytes in PB of MALT patients belong to the lymphoma clone and migrate to MIG expressing mucosa associated lymphoid tissue . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| CXCR 3 was functional , inducing a rise in cytosolic free Ca2+ , actin reorganization , and chemotaxis in response to the CXC ligands CXCL 9 , 10 , and 11 . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| Transcript levels of CXCR 3 and its ligands , interferon inducible protein 10 ( IP 10 ) and monokine induced by IFN gamma ( Mig ) , significantly increased between early and late time points together with expression of MIP 1alpha , regulated on activation normal T expressed and secreted protein ( RANTES ) and MCP 1 . ^^^ CONCLUSIONS : Our data suggest that CXCR 3 , with ligands IP 10 and Mig , is involved in T cell recruitment in acute islet xenograft rejection in non human primates . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| Accumulation of CXCR 3 expressing eosinophils and increased concentration of its ligands ( IP 10 and Mig ) in bronchoalveolar lavage fluid of patients with chronic eosinophilic pneumonia . ^^^ BACKGROUND : Since human peripheral eosinophils have been shown to migrate to the CXC chemokine receptor 3 ( CXCR 3 ) ligands IFN gamma inducible protein 10 ( IP 10 ) and monokine induced by IFN gamma ( Mig ) , this confirms that CXCR 3 is functionally expressed on these cells . ^^^ To examine the contribution of IP 10 and Mig in the pathogenesis of CEP , we measured the concentration of IP 10 and Mig , and evaluated the expression of CXCR 3 on eosinophils in BALF taken from patients with CEP . ^^^ CONCLUSIONS : Our findings suggest that IP 10 and Mig contribute to the accumulation of CXCR 3 expressing eosinophils in the lungs of patients with CEP , and modulate the eosinophilic inflammation of the lung . . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| The expression of MIG was correlated with that of MUM 1 in B CLL cell lines , and treatment with neutralizing antibodies against MIG and its receptor , CXCR 3 , slightly inhibited the proliferation of two MUM 1 expressing lines . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| Gene and protein expression of CXCL 10 , CXCL 9 , and CXCR 3 was significantly lower in IFN gamma / compared with DBA / 1 WT thyroids . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| The present study investigated the role of the receptor for CXCL 9 and CXCL 10 in the host response to HSV 1 infection using mice deficient in CXCR 3 expression ( CXCR 3 / ) . ^^^ Coinciding with the increase in virus titer , CCL 5 , CXCL 9 , CXCL 10 and IFN gamma protein levels were enhanced in the trigeminal ganglion and / or brain stem of the CXCR 3 / mice associated with a 2 fold increase in the percentage of CD3+CD8+ T lymphocytes in the trigeminal ganglion . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| Quantitative real time PCR confirmed these findings and revealed up regulated mRNA levels of another chemoattractant that activates CXCR 3 , monokine induced by IFN gamma ( Mig ; CXCL 9 ) . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| RESULTS : In the present study , we identified the CXCR 3 ligands CXCL 9 ( interferon gamma [ IFNgamma ] induced monokine ) , CXCL 10 ( IFNgamma inducible protein 10 ) , and CXCL 11 ( IFN inducible T cell alpha chemoattractant ) as being the most abundantly expressed chemokine family members in cutaneous LE . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| Infiltrating T cells , confined to the adventitia and intima , expressed CXCR 3 and CCR 5 , but were not recruited into the media despite production by vascular smooth muscle cells of IP 10 , Mig , 1 TAC , RANTES and MIP 1beta . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| However , the CXCR 3 ligand , Mig , did not affect the migration or invasiveness of CXCR 3 positive cells . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : Two variants of the CXCR 3 receptor exist , one ( CXCR 3 A ) reactive with CXCL 9 , CXCL 10 , and CXCL 11 and the other ( CXCR 3 B ) also reactive with CXCL 4 . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| In uninfected mice , IL 4 producing T cells preferentially migrated to the CCR 4 ligand , CCL 17 , whereas IFN gamma expressing T cells as well as populations of IL 4+ or IL 10+ T cells migrated to the CXCR 3 ligand , CXCL 9 . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| CXCR 3 and its ligands , CXCL 11 , CXCL 10 , and CXCL 9 , play a major role in T helper 1 ( Th 1 ) dependent inflammatory responses . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| The IFN gamma inducible and CXCR 3 targeting human CXC chemokines CXCL 9 ( Mig ) and CXCL 10 ( IP 10 ) have potent antitumor activity through attraction of cytotoxic T lymphocytes and inhibition of angiogenesis . ^^^ The more recently identified CXCR 3 targeting chemokine CXCL 11 ( 1 TAC / IP9 ) proved to be a more potent chemokine than CXCL 9 and CXCL 10 in vitro , both in chemotaxis assays with CXCR3+ T lymphocytes and in calcium mobilization experiments . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| Specimens with inner media infiltration displayed robust production of IFN gamma , induction of the IFN gamma inducible chemokines IP 10 and Mig , and recruitment of lymphocytes bearing their cognate receptor CXCR 3 . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| CXCR 3 is a Galpha ( 1 ) protein coupled receptor that binds the proinflammatory chemokines CXCL 9 , CXCL 10 , and CXCL 11 , which are released from the intestinal epithelium . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| Serum ELISAs were performed to detect the CCR 5 ligands CCL 5 , CCL 3 ; the CXCR 3 ligands CXCL 10 , CXCL 9 ; and the CCR 4 ligand , CCL 17 before and after administration of the TNFalpha blocking agent infliximab . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| Monokine induced by gamma interferon ( MIG / CXCL9 ) has been shown to be expressed by IFN gamma stimulated mononuclear cells and to attract activated T cells through the chemokine receptor CXCR 3 . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| We found that combined systemic IL 2 with an intratumor CXCR 3 ligand ( CXCL 9 ) lead to significantly greater reduction in tumor growth and angiogenesis , increased tumor necrosis , and increased intratumor infiltration of CXCR3+ mononuclear cells , as compared with either IL 2 or CXCL 9 alone . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| The data suggest that CNS infection provides strong stimuli to recruit ASC into the inflamed tissue through sustained up regulation of the CXCR 3 ligands CXCL 9 and CXCL 10 . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : Ligands for CXCR 3 chemokines [ IFN gamma inducible protein of 10 kD ( IP 10 / CXCL10 ) , monokine induced by IFN gamma ( Mig / CXCL9 ) , IFN inducible T cell alpha chemoattractant ( 1 TAC / CXCL11 ) ] and those for CCR 4 [ macrophage derived chemokine ( MDC / CCL22 ) , thymus and activation regulated chemokine ( TARC / CCL17 ) ] have been shown to play the central roles for T helper cell recruitment into the tissues . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| This study compared the potency and efficacy of three CXCR 3 ligands , 1 TAC / CXCL11 , IP 10 / CXCL10 , and Mig / CXCL9 , as inducers of chemotaxis in HAEC and examined the underlying signaling pathways involved . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| Furthermore , despite marked up regulation of the two remaining CXCR 3 ligands : CXCL 9 and 11 , we found a reduced accumulation of CD 8 ( + ) T cells in the brain parenchyma around the time point when wild type mice succumb as a result of CD 8 ( + ) T cell mediated inflammation . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| CXCR 3 , the receptor for CXCL 10 , CXCL 9 , and CXCL 11 , is preferentially expressed on activated Th 1 T cells and has been proposed to govern the migration of lymphocytes into the inflamed CNS during multiple sclerosis and EAE . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| CXCL 10 replacement partially restored Th 1 cell trafficking in STAT 1 deficient mice in vivo , and deficiency in CXCR 3 , the receptor for CXCL 9 , CXCL 10 , and CXCL 11 , impaired the trafficking of adoptively transferred Th 1 cells in wild type mice . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| In addition to the chemokine , interferon gamma inducible protein 10 kDa ( IP 10 , CXCL 10 ) , the chemokine receptor , CXCR 3 , also recognizes two other chemokines ; monokine induced by IFN gamma ( MIG , CXCL 9 ) and IFN inducible T cell alpha chemoattractant ( 1 TAC , CXCL 11 ) . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| This study further elucidates the roles of selected chemokines ( IP 10 , MIG , and RANTES ) and their receptors ( CCR 3 , CCR 5 , and CXCR 3 ) in asthma . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVES : To investigate tissue samples from patients with CD30+ CLPD for the expression of the chemokine receptors CXCR 3 , CCR 4 and CCR 3 and their ligands MIG , TARC and RANTES . ^^^ We also found that LyP cells expressed CXCR 3 , which might support their migration towards the CXCR 3 ligand MIG , which is expressed in stromal cells of the skin . . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| IFNbeta markedly upregulated CXCR 3 ligand chemokines ( SCYB 11 , SCYB 10 and SCYB 9 ) chiefly active on effector T helper type 1 ( Th 1 ) T cells , and CCR 2 ligand chemokines ( SCYA 8 and SCYA 2 ) effective on monocytes , whereas it downregulated CXCR 2 ligand chemokines ( SCYB 2 , SCYB 1 and IL 8 ) primarily active on neutrophils . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| The chemokine receptor CXCR 3 and two of its ligands , CXCL 9 and CXCL 10 , have been identified as important mediators of OB . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| Therefore , MIG antiserum or CXCR 3 antiserum was administered to the rat skin engrafted mice every other day until rejection . ^^^ RESULTS : Compared with the control normal rabbit serum treated mice , either the MIG antiserum or CXCR 3 antiserum treated mice showed a delayed rejection of approximately 2 days ( 8 . 3 + / 0 . 5 days vs . 10 . 6 + / 0 . 5 days or 10 . 8 + / 1 . 9 days , respectively , P < 0 . 05 ) . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| Three gamma interferon inducible chemokines activate CXCR 3 : CXCL 9 ( Mig ) , CXCL 10 ( IP 10 ) , and CXCL 11 ( 1 TAC ) . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| TLR ligands and cytokines induce CXCR 3 ligands in endothelial cells : enhanced CXCL 9 in autoimmune arthritis . ^^^ In contrast to CXC chemokine ligand 8 ( CXCL 8 ) , no CXC chemokine receptor 3 ( CXCR 3 ) ligand ( ie CXCL 9 , CXCL 10 and CXCL 11 ) was induced by bacterial TLR ligands in human microvascular endothelial cells ( HMVEC ) . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemistry showed that the degree of CXCR 3 positive cell infiltration significantly correlated with IFN gamma inducible protein 10 , MIG and IFN gamma inducible T cell a chemoattractant expression ( 1 TAC ) . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| Interaction of CXCR 3 ligands , CXCL 9 , CXCL 10 , and CXCL 11 , with CXCR 3 on the highly malignant murine mammary tumor cell line 66 . 1 resulted in intracellular calcium mobilization and chemotaxis in vitro . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| We investigated the effects of heparin on the IFN gamma inducible chemokines IP 10 / CXCL10 , 1 TAC / CXCL11 , and Mig / CXCL9 , which play important roles in the vascular recruitment of IFN gamma producing Th 1 cells through interactions with their cognate receptor , CXCR 3 . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| Tissue slides were stained for a variety of cell markers ( CD 3 , CD 4 , CD 8 , CD 20 , CD 68 , CD79a ) , chemokines ( monokine induced by interferon [ MIG ] , interferon inducible protein 10 [ IP 10 ] , interferon inducible T cell alpha chemoattractant [ ITAC ] , RANTES [ regulated on activation normal T cell expressed and secreted ] , and fractalkine ) , and chemokine receptors ( CXCR 3 , CCR 5 , and CX3CR1 ) . ^^^ |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49682 and Q07325 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.66228882 |
| Using the highly invasive melanoma cell line BLM , we demonstrate that the chemokine Mig , a ligand for CXCR 3 , activates the small GTPases RhoA and Rac 1 , induces a reorganization of the actin cytoskeleton , and triggers cell chemotaxis and modulation of integrin VLA 5 and VLA 4 dependent cell adhesion to fibronectin . 0.66228882^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| Since chemokine receptors CXCR 3 and CCR 5 are preferentially expressed on Th 1 cells , we tested the expression and regulation of several chemokines , including those that signal through CXCR 3 ( interferon gamma inducible protein of 10 kDa , IP 10 , CXCL 10 ; and monokine induced by interferon gamma , Mig , CXCL 9 ) and CCR 5 ( macrophage inflammatory protein ( Mip ) 1 alpha , CCL 3 ; and Mip 1 beta , CCL 4 ) in RA synovial fluids , synovial tissues , and blood . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| Serial analysis of allografts showed that intragraft expression of the three chemokine ligands for the CXC chemo kine receptor CXCR 3 was induced in the order of interferon ( IFN ) gamma inducible protein of 10 kD ( IP 10 , or CXCL 10 ) , IFN inducible T cell alpha chemoattractant ( 1 TAC ; CXCL 11 ) , and then monokine induced by IFN gamma ( Mig , CXCL 9 ) . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| Here , the biological activity and expression patterns of murine CXCL 11 relative to CXCL 9 ( MIG ) and CXCL 10 ( IP 10 / crg 2 ) , the other two CXCR 3 ligands , were assessed . ^^^ Calcium mobilization and chemotaxis experiments demonstrated that murine CXCL 11 stimulated murine CXCR 3 at much lower doses than murine CXCL 9 or murine CXCL 10 . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| Differential expression of CXCR 3 targeting chemokines CXCL 10 , CXCL 9 , and CXCL 11 in different types of skin inflammation . ^^^ As CXCR 3 activating chemokines CXCL 10 ( IP 10 ) , CXCL 9 ( Mig ) , and CXCL 11 ( IP 9 / I TAC ) specifically attract activated T cells , this study addressed the question of whether differences in the expression of these chemokines correlate with the site and cellular composition of the skin infiltrates in different types of inflammatory skin disease . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| Using neutralizing mAbs to IFN induced protein 10 ( CXCL 10 ) , monokine induced by IFN gamma ( CXCL 9 ) , and IFN inducible T cell alpha chemoattractant ( 1 TAC ; CXCL 11 ) , we found that even though 1 TAC was secreted from IFN gamma activated HSVEC to lower levels than IFN induced protein 10 or the monokine induced by IFN gamma , it was the principal chemokine responsible for CXCR 3 internalization . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| In contrast to CXCR 4 , the expression levels of the chemokine receptor CXCR 3 and the migration of cells in response to CXCL 9 and CXCL 10 increased after IL 2 treatment . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| The chemokines CXCL 9 , 10 , and 11 exert their action via CXC chemokine receptor 3 ( CXCR 3 ) , a receptor highly expressed on activated T cells . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| Human microvascular endothelial cell line 1 ( HMEC 1 ) , transfected with either the known CXCR 3 ( renamed CXCR 3 A ) or CXCR 3 B , bound CXCL 9 , CXCL 10 , and CXCL 11 , whereas CXCL 4 showed high affinity only for CXCR 3 B . ^^^ Remarkably , primary cultures of human microvascular endothelial cells , whose growth is inhibited by CXCL 9 , CXCL 10 , CXCL 11 , and CXCL 4 , expressed CXCR 3 B , but not CXCR 3 A . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| CCR 3 functional responses are regulated by both CXCR 3 and its ligands CXCL 9 , CXCL 10 and CXCL 11 . ^^^ The chemokine receptor CXCR 3 is predominantly expressed on T lymphocytes , and its agonists CXCL 9 , CXCL 10 and CXCL 11 are IFN gamma inducible chemokines that promote Th 1 responses . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| High CXCR 3 expression in synovial mast cells associated with CXCL 9 and CXCL 10 expression in inflammatory synovial tissues of patients with rheumatoid arthritis . ^^^ These findings suggest that substantial expression of CXCR 3 protein on mast cells within synovial tissue from RA patients plays a significant role in the pathophysiology of RA , accompanied by elevated levels of the chemokines CXCL 9 and CXCL 10 . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| The expression of the CXCR 3 ligands CXCL 9 and CXCL 10 was significantly higher than the other chemokines investigated . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| CXCR 3 is a chemokine receptor predominantly expressed on T lymphocytes , and binds the chemokines CXCL 9 ( Mig ) , CXCL 10 ( IP 10 ) and CXCL 11 ( 1 TAC ) . ^^^ In contrast , the N terminus and first extracellular loop of CXCR 3 play some role in CXCL 10 and CXCL 11 mediated activation but are dispensable for CXCL 9 induced signaling . ^^^ The third extracellular loop of CXCR 3 is important only for CXCL 9 and CXCL 10 induced chemotaxis . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| The ELR negative CXC chemokines CXCL 9 , CXCL 10 , and CXCL 11 ) are potent chemoattractants for mononuclear cells and act through their shared receptor , CXCR 3 . ^^^ We performed studies in a rat orthotopic lung transplantation model of acute rejection , and demonstrated increased expression of CXCL 9 and CXCL 10 paralleling the recruitment of mononuclear cells and cells expressing CXCR 3 to the allograft . ^^^ Inhibition of CXCL 9 decreased intragraft recruitment of mononuclear cells and cellular expression of CXCR 3 , resulting in lower acute lung allograft rejection scores . ^^^ This supports the notion that CXCL 9 interaction with cells expressing CXCR 3 has an important role in the recruitment of mononuclear cells , a pivotal event in the pathogenesis of acute lung allograft rejection . . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| Among the potent Th 1 type chemokines inhibited were the CXCR 3 ligands CXCL 9 and CXCL 10 , which could directly inhibit vector mediated gene expression in myoblasts , although targeting CXCR 3 or its ligands did not prolong allograft survival with vIL 10 gene transfer . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| Among CXCR 3 chemokines , IFN gamma inducible protein of 10 kDa ( CXC chemokine ligand ( CXCL ) 10 ) but not monokine induced by IFN gamma ( CXCL 9 ) imprints a pattern for the subsequent development of autoimmune disease . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| We now show that islet allograft rejection is associated with a steady increase in intragraft expression of the chemokines CCL 8 ( monocyte chemoattractant protein 2 ) , CCL 9 ( monocyte chemoattractant protein 5 ) , CCL 5 ( RANTES ) , CXCL 10 ( IFN gamma inducible protein 10 ) , and CXCL 9 ( monokine induced by IFN gamma ) and their corresponding chemokine receptors CCR 2 , CCR 5 , CCR 1 , and CXCR 3 . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| In addition , the relative roles of the chemokines that bind CXCR 3 ( CXCL 9 , CXCL 10 , CXCL 11 ) and CCR 5 ( CCL 3 , CCL 4 , CCL 5 ) in this process are unknown . ^^^ T lymphoblasts migrated in vitro to CXCR 3 ligands with a relative potency of CXCL 10 > CXCL 11 > CXCL 9 , but these cells demonstrated much less chemotaxis to the CCR 5 ligands . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| Because IFN gamma inducible chemokines , Mig ( CXCL 9 ) , IP 10 ( CXCL 10 ) , 1 TAC ( CXCL 11 ) and their receptor , CXCR 3 , are critical molecules in T cell trafficking and generation of effector T cells , we examined their expression in the muscle biopsies of patients with sporadic inclusion body myositis ( s IBM ) and disease controls . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| In this study , we investigated the production of the CXCR 3 agonistic chemokines CXCL 9 , CXCL 10 , and CXCL 11 by synovial tissue cells and synovial fibroblast cell lines ( fourth or fifth passage ) from RA patients . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| Importantly , such a stimulation of metastasis was largely suppressed when CXCR 3 expression in B16F10 cells was reduced by antisense RNA or when mice were treated with specific antibodies against CXCL 9 and CXCL 10 . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| The selective CXC chemokine receptor 3 ( CXCR 3 ) agonists , monokine induced by interferon gamma ( IFN gamma ) / CXC chemokine ligand 9 ( CXCL 9 ) , IFN inducible protein 10 / CXCL10 , and IFN inducible T cell alpha chemoattractant ( 1 TAC ) / CXCL11 , attract CXCR3+ cells such as CD45RO+ T lymphocytes , B cells , and natural killer cells . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| Regulation of cockroach antigen induced allergic airway hyperreactivity by the CXCR 3 ligand CXCL 9 . ^^^ The CXCR 3 ligands , CXCL 9 ( monokine induced by IFN gamma ) and CXCL 10 ( IFN inducible protein , 10 kDa ) , are IFN gamma inducible , Th 1 type chemokines . ^^^ Taken together , our results demonstrate that the CXCR 3 ligand CXCL 9 is involved in regulation of the allergic response in the lung by regulation of lymphocyte activation and eosinophil recruitment . . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| CXCL 11 ( ITAC ) is one of three chemokines known to bind the receptor CXCR 3 , the two others being CXCL 9 ( Mig ) and CXCL 10 ( IP 10 ) . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| We found both in skin lesions and in invaded lymph nodes an expression by tumor cells of CXCR 3 , CXCR 4 , and CCR 7 , and the concomitant expression by cells in the microenvironment of their respective ligands CXCL 9 , CXCL 12 , and CCL 19 . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| The effects of two regulatory cytokines , TNFalpha and IFNgamma , on the expression of CD 54 ( ICAM 1 ) and CD 106 ( VCAM 1 ) adhesion molecules and the CXCR 3 ligands ( CXCL 9 , CXCL 10 , CXCL 11 ) , were assessed in a primary culture of human OB by real time PCR , flow cytometry , and immunohistochemistry . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| Synergistic induction of CXCL 9 and CXCL 11 by Toll like receptor ligands and interferon gamma in fibroblasts correlates with elevated levels of CXCR 3 ligands in septic arthritis synovial fluids . ^^^ Enhanced levels of the CXC chemokine ligand ( CXCL 9 ) / monokine induced by interferon gamma ( IFN gamma ) and CXCL11 / IFN inducible T cell alpha chemoattractant , two chemoattractants for activated T cells and natural killer cells , and ligands for CXC chemokine receptor 3 ( CXCR 3 ) were detected in the synovial fluid of septic arthritis compared with osteo and crystal arthritis patients . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| Most impressively , mRNA for CXCR 3 , the receptor for CXCL 9 and CXCL 10 , was massively up regulated in the lungs of SARS CoV infected mice . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| T lymphocytes are the most important effectors of immunity , and the CXCR 3 ligands CXCL 9 and CXCL 10 may play an important role in the T cell mediated clearance of rickettsiae from the infected vasculature as suggested by recent expression studies . ^^^ Here we showed that antibody mediated neutralization of CXCL 9 and CXCL 10 , and CXCR 3 gene knockout , had no effect on survival or bacterial loads of mice infected with rickettsiae . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| In this study , we evaluated the roles of the chemokines MIG ( CXCL 9 ) , IP 10 ( CXCL 10 ) , and 1 TAC ( CXCL 11 ) and their common receptor , CXCR 3 . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| CXCR 3 was functional , inducing a rise in cytosolic free Ca2+ , actin reorganization , and chemotaxis in response to the CXC ligands CXCL 9 , 10 , and 11 . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| The three CXCR 3 ligands CXCL 9 , CXCL 10 , and CXCL 11 are produced at sites of inflammation and elicit migration of pathological Th 1 cells . ^^^ There was a striking difference in potencies among the three CXCR 3 ligands , with CXCL 11 > > CXCL 10 > CXCL 9 . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| The chemokines ( CXCL 9 , CXCL 10 and CXCL 11 ) and associated CXCR 3 receptor are expressed during the inflammatory process from multiple sclerosis , atherosclerosis or organ transplantation resulting in the recruitment of lymphocytes leading to tissue damage . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| The present study investigated the role of the receptor for CXCL 9 and CXCL 10 in the host response to HSV 1 infection using mice deficient in CXCR 3 expression ( CXCR 3 / ) . ^^^ Coinciding with the increase in virus titer , CCL 5 , CXCL 9 , CXCL 10 and IFN gamma protein levels were enhanced in the trigeminal ganglion and / or brain stem of the CXCR 3 / mice associated with a 2 fold increase in the percentage of CD3+CD8+ T lymphocytes in the trigeminal ganglion . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| Quantitative real time PCR confirmed these findings and revealed up regulated mRNA levels of another chemoattractant that activates CXCR 3 , monokine induced by IFN gamma ( Mig ; CXCL 9 ) . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| RESULTS : In the present study , we identified the CXCR 3 ligands CXCL 9 ( interferon gamma [ IFNgamma ] induced monokine ) , CXCL 10 ( IFNgamma inducible protein 10 ) , and CXCL 11 ( IFN inducible T cell alpha chemoattractant ) as being the most abundantly expressed chemokine family members in cutaneous LE . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| Gene and protein expression of CXCL 10 , CXCL 9 , and CXCR 3 was significantly lower in IFN gamma / compared with DBA / 1 WT thyroids . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| The IFN gamma inducible and CXCR 3 targeting human CXC chemokines CXCL 9 ( Mig ) and CXCL 10 ( IP 10 ) have potent antitumor activity through attraction of cytotoxic T lymphocytes and inhibition of angiogenesis . ^^^ The more recently identified CXCR 3 targeting chemokine CXCL 11 ( 1 TAC / IP9 ) proved to be a more potent chemokine than CXCL 9 and CXCL 10 in vitro , both in chemotaxis assays with CXCR3+ T lymphocytes and in calcium mobilization experiments . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| CXCR 3 is a Galpha ( 1 ) protein coupled receptor that binds the proinflammatory chemokines CXCL 9 , CXCL 10 , and CXCL 11 , which are released from the intestinal epithelium . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| Serum ELISAs were performed to detect the CCR 5 ligands CCL 5 , CCL 3 ; the CXCR 3 ligands CXCL 10 , CXCL 9 ; and the CCR 4 ligand , CCL 17 before and after administration of the TNFalpha blocking agent infliximab . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : Two variants of the CXCR 3 receptor exist , one ( CXCR 3 A ) reactive with CXCL 9 , CXCL 10 , and CXCL 11 and the other ( CXCR 3 B ) also reactive with CXCL 4 . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| In uninfected mice , IL 4 producing T cells preferentially migrated to the CCR 4 ligand , CCL 17 , whereas IFN gamma expressing T cells as well as populations of IL 4+ or IL 10+ T cells migrated to the CXCR 3 ligand , CXCL 9 . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| CXCR 3 and its ligands , CXCL 11 , CXCL 10 , and CXCL 9 , play a major role in T helper 1 ( Th 1 ) dependent inflammatory responses . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| We found that combined systemic IL 2 with an intratumor CXCR 3 ligand ( CXCL 9 ) lead to significantly greater reduction in tumor growth and angiogenesis , increased tumor necrosis , and increased intratumor infiltration of CXCR3+ mononuclear cells , as compared with either IL 2 or CXCL 9 alone . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| The data suggest that CNS infection provides strong stimuli to recruit ASC into the inflamed tissue through sustained up regulation of the CXCR 3 ligands CXCL 9 and CXCL 10 . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| Furthermore , despite marked up regulation of the two remaining CXCR 3 ligands : CXCL 9 and 11 , we found a reduced accumulation of CD 8 ( + ) T cells in the brain parenchyma around the time point when wild type mice succumb as a result of CD 8 ( + ) T cell mediated inflammation . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| CXCR 3 , the receptor for CXCL 10 , CXCL 9 , and CXCL 11 , is preferentially expressed on activated Th 1 T cells and has been proposed to govern the migration of lymphocytes into the inflamed CNS during multiple sclerosis and EAE . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| CXCL 10 replacement partially restored Th 1 cell trafficking in STAT 1 deficient mice in vivo , and deficiency in CXCR 3 , the receptor for CXCL 9 , CXCL 10 , and CXCL 11 , impaired the trafficking of adoptively transferred Th 1 cells in wild type mice . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| In addition to the chemokine , interferon gamma inducible protein 10 kDa ( IP 10 , CXCL 10 ) , the chemokine receptor , CXCR 3 , also recognizes two other chemokines ; monokine induced by IFN gamma ( MIG , CXCL 9 ) and IFN inducible T cell alpha chemoattractant ( 1 TAC , CXCL 11 ) . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| The chemokine receptor CXCR 3 and two of its ligands , CXCL 9 and CXCL 10 , have been identified as important mediators of OB . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| Three gamma interferon inducible chemokines activate CXCR 3 : CXCL 9 ( Mig ) , CXCL 10 ( IP 10 ) , and CXCL 11 ( 1 TAC ) . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| TLR ligands and cytokines induce CXCR 3 ligands in endothelial cells : enhanced CXCL 9 in autoimmune arthritis . ^^^ In contrast to CXC chemokine ligand 8 ( CXCL 8 ) , no CXC chemokine receptor 3 ( CXCR 3 ) ligand ( ie CXCL 9 , CXCL 10 and CXCL 11 ) was induced by bacterial TLR ligands in human microvascular endothelial cells ( HMVEC ) . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| Interaction of CXCR 3 ligands , CXCL 9 , CXCL 10 , and CXCL 11 , with CXCR 3 on the highly malignant murine mammary tumor cell line 66 . 1 resulted in intracellular calcium mobilization and chemotaxis in vitro . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| Mig is related functionally to interferon inducible protein 10 ( IP 10 ) , with which it shares a receptor , CXCR 3 . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| Particularly important chemokines for activated / memory T cells are the CXCR 3 ligands IP 10 and Mig and the CCR 5 ligands RANTES , macrophage inflammatory protein 1alpha , and macrophage inflammatory protein 1beta . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| This was confirmed by functional responses : only Th2s responded with an increase in [ Ca2+ ] 1 to the CCR 3 and CCR 4 agonists eotaxin and thymus and activation regulated chemokine ( TARC ) , whereas only Th0s and Th1s responded to low concentrations of the CXCR 3 agonists IFN gamma inducible protein 10 ( IP 10 ) and monokine induced by IFN gamma ( Mig ) . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| The chemokine receptor CXCR 3 mediates rapid and shear resistant adhesion induction of effector T lymphocytes by the chemokines IP 10 and Mig . ^^^ We show that the chemokines 10 kDa inflammatory protein ( IP 10 ) and monokine induced by IFN ( Mig ) induce rapid and transient adhesion of human IL 2 stimulated T lymphocytes ( IL 2 T cells ) to immobilized integrin ligands through their receptor CXCR 3 , which is selectively expressed on activated T cells . ^^^ No effect was seen with resting naive / memory T cells which lack CXCR 3 and migration responses to IP 10 and Mig . ^^^ Under conditions of flow , IL 2 T cells roll and rapidly adhere to IP10 / Mig expressing HUVEC , and anti CXCR 3 mAb treatment reduces arrest and firm adhesion . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| We now report the pharmacological characterization of CXCR 3 and find that , when heterologously expressed , CXCR 3 binds IP 10 and MIG with Ki values of 0 . 14 and 4 . 9 nM , respectively . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| Expression of CXCR 3 , the receptor for the CXC chemokines IFN gamma inducible 10 kDa protein ( IP 10 ) and monokine induced by IFN gamma ( Mig ) , in human T lymphocytes and their responses to IP 10 and Mig were analyzed . ^^^ Addition of chondroitin sulfate C to CXCR 3 expressing murine pre B cells allowed the determination of high affinity binding for Mig and IP 10 with Kd of 0 . 9 1 . 2 nM and 0 . 2 0 . 3 nM , respectively , and 1 . 3 10 10 ( 4 ) binding sites per cell . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| CXCR 3 , an IP 10 / Mig receptor , was expressed on lymphocytic cells in virtually every perivascular inflammatory infiltrate in active MS lesions . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| We therefore asked whether the CXC chemokines IFN induced protein of 10 kDa ( IP 10 ) , monokine induced by IFN gamma ( Mig ) , and IFN inducible T cell alpha chemoattractant ( 1 TAC ) , which specifically chemoattract activated T cells by signaling through the chemokine receptor CXCR 3 , were inducible in respiratory epithelial cells . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| Monokine induced by IFN gamma ( MIG ) , IFN inducible T cell alpha chemoattractant ( 1 TAC ) , and IFN gamma inducible protein of 10 kDa ( IP 10 ) are related members of the CXC chemokine subfamily that bind to a common receptor , CXCR 3 , and that are produced by different cell types in response to IFN gamma . ^^^ Finally , supernatants harvested from stimulated PMN induced migration and rapid integrin dependent adhesion of CXCR 3 expressing lymphocytes ; these activities were significantly reduced by neutralizing anti MIG and anti IP 10 Abs , suggesting that they were mediated by MIG and IP 10 present in the supernatants . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| Human IP 9 : A keratinocyte derived high affinity CXC chemokine ligand for the IP 10 / Mig receptor ( CXCR 3 ) . ^^^ By this approach we were able to isolate IP 10 and Mig , and in addition identified a novel highly potent ligand for the CXCR 3 receptor , designated interferon gamma inducible protein 9 , which proved to be chemotactic for activated T cells expressing CXCR 3 . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| The migration elicited by IP 10 and Mig was inhibited by blocking CXCR 3 . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| Increased intragraft expression of interferon y and the interferon gamma induced chemokines , inducible protein 10 and Mig , and infiltration by activated mononuclear cells expressing CXCR 3 , the receptor for inducible protein 10 and Mig , was also seen . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| It was found that the CXCR 3 ligands , MIG and interferon gamma inducible protein 10 ( IP 10 ) , unlike SLC , did not induce chemotaxis of CD34+ HPC . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| The CXCR 3 activating chemokines IP 10 , Mig , and IP 9 are expressed in allergic but not in irritant patch test reactions . ^^^ In the present study , we investigated whether the mRNA expression of IP 10 and the related CXCR 3 activating chemokines , Mig and IP 9 are also differentially expressed in human allergic contact dermatitis and irritant contact dermatitis reactions . ^^^ Results of chemokine mRNA expression were correlated with clinical scoring , histology , and immunohistochemical data including the proportion of inflammatory cells expressing CXCR 3 , the receptor for IP 10 , Mig , and IP 9 , and ICAM 1 and HLA DR expression on keratinocytes . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| The present study demonstrates the differential expression of the 3 IFN gamma inducible CXC chemokines IFN inducible protein 10 ( IP 10 ) , monokine induced by IFN gamma ( Mig ) , and IFN inducible T cell alpha chemoattractant ( 1 TAC ) by atheroma associated cells , as well as the expression of their receptor , CXCR 3 , by all T lymphocytes within human atherosclerotic lesions in situ . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| The chemokine receptor CXCR 3 has been previously shown to be widely expressed on activated T cells and to mediate T cell chemotaxis on binding to various ligands , including Mig , IP 10 , and ITAC . ^^^ We also report that the CXCR 3 ligand , Mig , is coexpressed on tumor cells in many cases of CLL / SLL ( 10 of 13 cases examined ) with Mig expression less frequently seen in other B cell lymphoma subtypes . ^^^ Coexpression of CXCR 3 and its ligand , Mig , may be an important functional interaction in B CLL , as well as a useful diagnostic marker for the differential diagnosis of small cell lymphomas . ( Blood . 2000 ; 95 : 627 632 ) . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| Expression of the interferon gamma inducible chemokines IP 10 and Mig and their receptor , CXCR 3 , in multiple sclerosis lesions . ^^^ Using immunocytochemistry , the expression of the alpha chemokines , interferon ( IFN ) gamma inducible protein 10 ( IP 10 ) and monokine induced by IFN gamma ( Mig ) , and their receptor CXCR 3 have been examined in post mortem central nervous system ( CNS ) tissue from MS cases at different stages of lesion development . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| Gamma interferon ( IFN gamma ) inducible protein 10 ( IP 10 ) and monokine induced by IFN gamma ( Mig ) are related CXC chemokines which bind to the CXCR 3 receptor and specifically target activated T lymphocytes and natural killer ( NK ) cells . ^^^ IP 10 and Mig may contribute to host defense in Th 1 mediated host defense during infections by attracting CXCR 3 ( + ) Th 1 cells to the site of inflammation . . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| The chemokines Mig ( CXCR 3 ligand ) , TARC ( CCR 4 ligand ) , and MCP 2 ( CCR 5 ligand ) were detected in intratumoral blood vessels and histiocytes . ^^^ Mig was also coexpressed by a subset of CXCR 3 positive tumor cells in 6 of 20 lymphomas . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| Moreover , we showed that CXCR 3 ligands , IP 10 and Mig , were able to activate ERK1 / 2 pathway in mouse cortical neurons , suggesting a novel mechanism of neuronal glial interaction . . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| IFN induced protein of 10 kDa ( IP 10 ) , monokine induced by IFN gamma ( Mig ) , and IFN inducible T cell alpha chemoattractant ( 1 TAC ) belong to the non glutamate leucine arginine motif CXC chemokine family and act solely through the CXCR 3 receptor for potent attraction of T lymphocytes . ^^^ In this study , we evaluated the capacity of the T cell derived cytokines IL 4 , IL 10 , and IL 17 to modulate IP 10 , Mig , and 1 TAC in cultured human keratinocytes and CXCR 3 expression in T cells from allergic contact dermatitis ( ACD ) . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| Transfection of murine CXCR 3 in murine pre B lymphocyte line ( CXCR3++ / L1 . 2 ) conferred binding of the ligands IP 10 , ITAC and Mig with K ( D ) ' s of 1 . 35 + / 0 . 56 , 1 . 41 + / 0 . 20 , and 11 . 65 + / 0 . 90 nM , respectively . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| Role for interactions between IP 10 / Mig and CXCR 3 in proliferative glomerulonephritis . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| CXC chemokine receptor 3 ( CXCR 3 ) , predominately expressed on memory / activated T lymphocytes , is a receptor for both IFN gamma inducible protein 10 ( gamma IP 10 ) and monokine induced by IFN gamma ( Mig ) . ^^^ We report a novel finding that CXCR 3 is also expressed on eosinophils . gamma IP 10 and Mig induce eosinophil chemotaxis via CXCR 3 , as documented by the fact that anti CXCR 3 mAb blocks gamma IP 10 and Mig induced eosinophil chemotaxis . gamma IP 10 and Mig induced eosinophil chemotaxis are up and down regulated by IL 2 and IL 10 , respectively . ^^^ Correspondingly , CXCR 3 protein and mRNA expressions in eosinophils are up and down regulated by IL 2 and IL 10 , respectively , as detected using flow cytometry , immunocytochemical assay , and a real time quantitative RT PCR technique . gamma IP 10 and Mig act eosinophils to induce chemotaxis via the cAMP dependent protein kinase A signaling pathways . ^^^ The fact that gamma IP 10 and Mig induce an increase in intracellular calcium in eosinophils confirms that CXCR 3 exists on eosinophils . ^^^ These results indicate that CXCR 3 gamma IP 10 and Mig receptor ligand pairs as well as the effects of IL 2 and IL 10 on them may be especially important in the cytokine / chemokine environment for the pathophysiologic events of allergic inflammation , including initiation , progression , and termination in the processes . . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| CXC chemokine receptor 3 ( CXCR 3 ) , which is known to be expressed predominately on memory and activated T lymphocytes , is a receptor for both interferon gamma ( IFN gamma ) inducible protein 10 ( gamma IP 10 ) and monokine induced by IFN gamma ( Mig ) . ^^^ Freshly isolated CD 34 ( + ) progenitors expressed low levels of CXCR 3 messenger RNA , but this expression was highly up regulated by GM CSF , as indicated by a real time quantitative reverse transcriptase polymerase chain reaction technique . gamma IP 10 and Mig induced chemotaxis of GM CSF stimulated CD 34 ( + ) progenitors by means of CXCR 3 , since an anti CXCR 3 monoclonal antibody ( mAb ) was found to block gamma IP 10 induced and Mig induced CD 34 ( + ) progenitor chemotaxis . ^^^ These chemotactic attracted CD 34 ( + ) progenitors are colony forming units granulocyte macrophage . gamma IP 10 and Mig also induced GM CSF stimulated CD 34 ( + ) progenitor adhesion and aggregation by means of CXCR 3 , a finding confirmed by the observation that anti CXCR 3 mAb blocked these functions of gammaIP 10 and Mig but not of chemokine stromal cell derived factor 1 alpha . gamma IP 10 induced and Mig induced up regulation of integrins ( CD49a and CD49b ) was found to play a crucial role in adhesion of GM CSF stimulated CD 34 ( + ) progenitors . ^^^ Moreover , gamma IP 10 and Mig stimulated CXCR 3 redistribution and cellular polarization in GM CSF stimulated CD 34 ( + ) progenitors . ^^^ These results indicate that CXCR 3 gamma IP 10 and CXCR 3 Mig receptor ligand pairs , as well as the effects of GM CSF on them , may be especially important in the cytokine / chemokine environment for the physiologic and pathophysiologic events of differentiation of CD 34 ( + ) hematopoietic progenitors into lymphoid and myeloid stem cells , subsequently immune and inflammatory cells . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| Also , utilization of neutralizing antibodies to the CXCR 3 ligand Mig in murine allograft transplantation models has demonstrated the importance of CXCR 3 in orchestrating T cell mediated tissue rejection . . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| Assessment of the functional capacity of CXCR 3 unexpectedly revealed that HMECs migrated in response to relatively higher concentrations ( 100 500 ng / ml ) of each of the ' angiostatic ' chemokines IP 10 , ITAC , and MIG . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| Pulmonary T cells expressing CXCR 3 exhibited a high migratory capability in response to IP 10 and Mig . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| Here we show that acute cardiac allograft rejection is accompanied by progressive intragraft production of the chemokines interferon ( IFN ) gamma inducible protein of 10 kD ( IP 10 ) , monokine induced by IFN gamma ( Mig ) , and IFN inducible T cell alpha chemoattractant ( 1 TAC ) , and by infiltration of activated T cells bearing the corresponding chemokine receptor , CXCR 3 . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| CXCR 3 , the receptor for 1 TAC ( interferon inducible T cell alpha chemoattractant ) , Mig ( monokine induced by gamma interferon ) , and IP 10 ( interferon inducible protein 10 ) , is expressed preferentially on Th 1 cells , whereas CCR 3 , the receptor for eotaxin and several other CC chemokines , is characteristic of Th 2 cells . ^^^ While studying responses that are mediated by these two receptors , we found that the agonists for CXCR 3 act as antagonists for CCR 3 . 1 TAC , Mig , and IP 10 compete for the binding of eotaxin to CCR 3 bearing cells and inhibit migration and Ca ( 2+ ) changes induced in such cells by stimulation with eotaxin , eotaxin 2 , MCP 2 ( monocyte chemottractant protein 2 ) , MCP 3 , MCP 4 , and RANTES ( regulated on activation normal T cell expressed and secreted ) . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| IP 10 and Mig share a common functional receptor on activated T lymphocytes , named CXC chemokine receptor 3 ( CXCR 3 ) . ^^^ Both IP 10 and Mig , as well as the IFN gamma inducible T cell alpha chemoattractant ( 1 TAC ) , which all share high affinity binding for CXCR 3 , block HMVEC proliferation in vitro , an effect that can be inhibited by an anti CXCR 3 antibody . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| Quantitative analysis of mRNA expression in the colons of IL 4 treated mice showed an up regulation of both Th 1 and Th 2 associated molecules , including IFN gamma , IP 10 , MIG , CXCR 3 , chemokine receptor 8 , and IL 4 . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| RESULTS : IP 10 and Mig were constitutively expressed by normal human colon epithelium , and their cognate receptor , CXCR 3 , was expressed by mucosal mononuclear cells . ^^^ CONCLUSIONS : The constitutive and regulated production of the IFN gamma inducible chemokines IP 10 , Mig , and 1 TAC by human intestinal epithelium , and the expression of their cognate receptor , CXCR 3 , by mucosal mononuclear cells , suggest that the intestinal epithelium can play a role in modulating physiologic and pathologic T cell mediated mucosal inflammation . . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| We have shown that two other ligands of CXCR 3 , IP 10 and MIG , are potent inhibitors of tumor growth in severe combined immunodeficiency ( SCID ) mice . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| The human CXC chemokines IP 10 ( 10 kDa interferon inducible protein ) , MIG ( monokine induced by human interferon gamma ) , and 1 TAC ( interferon inducible T cell alpha chemoattractant ) attract lymphocytes through activation of CXCR 3 . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| CXCR 3 and CCR 4 were expressed by dermal CD3+ lymphocytes , and their chemokine ligands , IP 10 , MIG , TARC , and MDC , were up regulated in psoriatic lesions . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| Finally , CCR 3 expression by CD4+ / CD45RO+ T cells was positively correlated with plasma levels of its ligand , eotaxin , whereas strong negative correlations were evident between CXCR 3 expression and IP 10 or Mig . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| At the time of rejection in Mig antiserum treated recipients ( i . e . , days 17 19 ) , intra allograft expression of macrophage inflammatory protein 1alpha , 1beta , and their ligand CCR 5 was high , whereas expression of CXCR 3 , the Mig receptor , was virtually absent . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| CXCR 3 , known to have four ligands ( IFN gamma inducible protein 10 ( gamma IP 10 ) , monokine induced by IFN gamma ( Mig ) , 1 TAC , and 6Ckine ) , is predominantly expressed on memory / activated T lymphocytes . ^^^ We recently reported that GM CSF induces CXCR 3 expression on CD 34 ( + ) hemopoietic progenitors , in which gamma IP 10 and Mig induce chemotaxis and adhesion . ^^^ Thus , GM CSF binds to its receptor CD 116 , and consequently activates Syk phosphorylation , which leads to induce CXCR 3 expression . gamma IP 10 and Mig can induce Syk , Cbl , and Cbl b phosphorylation in CD 34 ( + ) progenitors by means of CXCR 3 . gamma IP 10 or Mig has induced neither chemotaxis nor adhesion in GM CSF stimulated Cbl b blocked CD 34 ( + ) hemopoietic progenitors , whereas SDF 1alpha induces both chemotaxis and adhesion in these cells . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| T lymphoblasts expressing CXCR 3 showed an increased migration to supernatants from stimulated TFCs , which was abolished by specific antibodies to the chemokines Ip 10 and Mig , as well as to their receptor CXCR 3 . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| We therefore characterized constitutive and regulated epithelial expression of the CXC chemokines IP 10 , 1 TAC and Mig , which specifically attract CXCR 3 expressing CD 4 ( + ) T cells . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| The interferon ( IFN ) inducible chemokines , specifically , IFN gamma inducible protein 10 ( IP 10 ) , monokine induced by IFN gamma ( Mig ) , and IFN inducible T cell alpha chemoattractant ( 1 TAC ) , share a unique CXC chemokine receptor ( CXCR 3 ) . ^^^ These data demonstrate a negative feedback regulation by CD26 / DPP 4 in CXCR 3 mediated chemotaxis without affecting the angiostatic potential of the CXCR 3 ligands IP 10 and Mig . . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| The number of CXCR 3 ( MIG and IP 10 receptor ) positive lymphocytes ( Th 1 lymphocytes ) was not different between MIG and IP 10 positive and negative HD . ^^^ Immunohistochemical staining was performed using antibodies for CXCR 3 ( a specific receptor for IP 10 and MIG ) , which is characteristic of Th 1 helper phenotype and CCR 3 , CCR 4 and ST 2 , which are features of Th 2 cells . ^^^ Lymphocytes surrounding MIG and IP 10 positive H & RS cells were more frequently CXCR 3 positive , however , compared to MIG and IP 10 negative cases . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| We detected constitutive expression of the MIG receptor , CXCR 3 , on the surface of the endothelial cells and therefore hypothesize that it plays a role in maintaining the cytokine gradient at the region of CNS inflammation . . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| The CXC chemokines ( monokine induced by IFN gamma ( MIG ) / CXC chemokine ligand ( CXCL ) 9 , IP 10 / CXCL10 , and IFN inducible T cell alpha chemoattractant ( ITAC ) / CXCL11 ) act through their shared receptor , CXCR 3 . ^^^ Translational studies in a murine model demonstrated increased expression of MIG / CXCL9 , IP 10 / CXCL10 , and ITAC / CXCL11 paralleling the recruitment of CXCR 3 expressing mononuclear cells . ^^^ In vivo neutralization of CXCR 3 or its ligands MIG / CXCL9 and IP 10 / CXCL10 decreased intragraft recruitment of CXCR 3 expressing mononuclear cells and attenuated BOS . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| Monokine induced by IFN gamma ( Mig ; CXC chemokine ligand 9 ) is an IFN gamma inducible CXC chemokine that signals through the receptor CXCR 3 and is known to function as a chemotactic factor for human T cells , particularly following T cell activation . ^^^ We have investigated the expression and activities of Mig and CXCR 3 in mouse cells and the role of Mig in models of host defense in mice . ^^^ Together , our data suggest that Mig and CXCR 3 may be important not only to recruit T cells to peripheral inflammatory sites , but also in some cases to maximize interactions among activated T cells , B cells , and dendritic cells within lymphoid organs to provide optimal humoral responses to pathogens . . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| Therefore , we investigated expression of IFN inducible protein 10 ( IP 10 ) , IFN inducible T cell alpha chemoattractant ( 1 TAC ) , monokine induced by IFN ( Mig ) , and their receptor CXCR 3 in consecutive endomyocardial biopsies ( n = 133 ) from human cardiac allografts and corresponding normal donor hearts ( n = 11 ) before transplantation . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| In addition , IFN gamma positive lymphocytes were frequently detected in the surrounding dead tissue , and the lymphocytes in the same area were frequently positive for CXCR 3 , a specific receptor of MIG and IP 10 . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| Mig , IP 10 , and CXCR 3 gene expression is predictive for the individual response of children with chronic allograft nephropathy to mycophenolate mofetil . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| Of note was the marked expression of both CXCR 3 and its ligand Mig on endothelial cells from portal neovessels in chronic hepatitis C . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| The expression of interferon ( IFN ) gamma inducible protein ( IP ) 10 , monokine induced by IFN gamma ( Mig ) , interferon inducible T cell alpha chemoattractant ( 1 TAC ) , regulated on activation normal T cell expressed and secreted ( RANTES ) , monocyte chemotactic protein ( MCP ) 1 , interleukin ( IL ) 8 , and the receptors CXCR 3 and CCR 5 were tested using quantitative , real time polymerase chain reaction . ^^^ RESULTS : Expression of IP 10 , Mig , 1 TAC , RANTES , CXCR 3 , and CCR 5 , but not MCP 1 and IL 8 , increased significantly in both grade 2 and grade 3 rejection ( P < / =0 . 0096 ) . ^^^ CONCLUSION : The expression of IP 10 , Mig , 1 TAC , RANTES , CXCR 3 , and CCR 5 in cardiac allografts significantly correlates with the presence and grade of acute rejection . . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| The IP 10 and MIG receptor CXCR 3 was detected in the bronchiolar epithelium of preterm lambs by immunostaining . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| Expression of chemokine receptor CXCR 3 and its ligand , mig , in gastric and thyroid marginal zone lymphomas . ^^^ Our study was designed to investigate the expression of CXCR 3 and its ligand Mig , and their relationships in MALT using immunohistochemistry . ^^^ In double staining , CXCR 3 Mig coexpressing lymphoma cells were abundant in high MALT of the stomach and thyroid , but rare in other subtypes . ^^^ Our results indicate a tendency for low grade MALT to contain CXCR 3 ( + ) Mig lymphoma cells , high grade to contain CXCR 3 ( + ) Mig+ and DL to contain CRCR 3 ( ) Mig lymphoma cells . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| Expression of CD 4 , CD8alpha , CD 40 , CD 86 , CD 28 , CD 31 and vascular endothelial growth factor was not different between the two tumor groups but expression of CD 40 ligand , CD 80 , NK1 . 1 and CXCR 3 was relatively lower in A11 / Mig tumors . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| This review discusses chemokine responses in relation to HSV infection of the cornea emphasizing the role of CXCR 3 chemokine signaling by the IFN gamma inducible ligands MIG , IP 10 and 1 TAC and includes discussion of their potential role in immunopathology in the nervous system . . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| Structure function relationship between the human chemokine receptor CXCR 3 and its ligands . 1 TAC , IP 10 , and Mig are interferon gamma inducible CXC chemokines that share the same G protein coupled receptor CXCR 3 , which is preferentially expressed on Th 1 lymphocytes . ^^^ A potent antagonist for CXCR 3 was obtained by NH ( 2 ) terminal truncation of 1 TAC . 1 TAC ( 4 73 ) , which lacks the first three residues , has no agonistic activity but competes for the binding of 1 TAC to CXCR 3 bearing cells and inhibits migration and Ca ( 2+ ) changes in such cells in response to stimulation with 1 TAC , IP 10 , and Mig . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| Unexpectedly , the allergen challenged lung ( a T helper 2 microenvironment ) was found to be associated with the expression of T helper 1 associated CXCR 3 ligands , monokine induced by IFN gamma ( Mig ) , and IFN gamma inducible protein of 10 kDa ( IP 10 ) . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| The CXC chemokines 1 TAC , Mig and IP 10 and their receptor CXCR 3 are associated with advanced stage tumor and contribute to tumor progression , invasion and metastasis . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| METHODS : Expression of inducible protein ( IP ) 10 , monokine induced by IFN gamma ( Mig ) , interferon inducible T cell alpha chemoattractant ( 1 TAC ) , regulated on activation normal T cell expressed and secreted ( RANTES ) , and their receptors CXCR 3 and CCR 5 was tested in 60 endomyocardial biopsies from 24 patients using quantitative ( Taqman ) real time polymerase chain reaction ( PCR ) . ^^^ RESULTS : IP 10 , Mig , RANTES , CXCR 3 , and CCR 5 expression levels were increased in the later versus earlier biopsies ( P < or =0 . 01 ) despite no change in histologic rejection grade status . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| Most of the CD3+ infiltrating lymphocytes in dense periductal foci expressed CXCR 3 , the receptor for IP 10 and Mig . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| Immunohistologic analysis of human renal transplant biopsies showed expression of inducible costimulator ( ICOS ) , the chemokine receptor CXCR 3 , and its ligands , Mig and IP 10 , by intraglomerular and periglomerular leukocytes in biopsies with CAN and TGP but not CAN alone . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| The PMN mediated regulation of granuloma formation depended on chemokines signaling through CXCR 3 , in particular MIG , as indicated by immune histochemical analysis of lung sections from C57BL / 6 wild type and CXCR 3 ( / ) mutant mice and supported by microarray transcriptome analysis . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| Monokine induced by IFN gamma ( MIG ) , IFN gamma inducible T cell alpha chemoattractant ( 1 TAC ) , and IFN gamma inducible protein 10 ( IP 10 ) , are chemokines that bind CXCR 3 and mediate the chemotaxis of leukocytes . ^^^ IP 10 , MIG , and CXCR 3 have been shown to be expressed at sites of CD . ^^^ To better understand the role of CXCR 3 interactions during CD , we characterized the effects of IP 10 , MIG , 1 TAC , and CXCR3+ T cells on mucosal immune responses . ^^^ Taken together , these studies suggest that IP 10 , MIG , 1 TAC , and CXCR 3 interactions are involved in mucosal immune responses required for the induction of CD . . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| PURPOSE : To examine the expression of the three interferon gamma inducible CXCR 3 binding chemokines , CXCL10 / IP 10 ( interferon gamma inducible protein of 10 KDa ) , CXCL9 / Mig ( monokine induced by interferon gamma ) , and CXCL11 / I TAC ( interferon inducible T cell alpha chemoattractant ) in the conjunctiva of patients with vernal keratoconjunctivitis ( VKC ) . ^^^ CONCLUSIONS : The CXC chemokine Mig is selectively and highly expressed in VKC suggesting a pathogenic role of the chemokine receptor CXCR 3 and the ligand Mig in the recruitment of activated T lymphocytes . . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| The authors examined expression of 1 TAC , Mig , and their receptor , CXCR 3 , in tissue samples from patients with renal cell carcinoma ( RCC ) . ^^^ The expression levels of 1 TAC , Mig , and CXCR 3 were investigated using reverse transcriptase polymerase chain reaction ( RT PCR ) analysis , real time RT PCR analysis , and Western blot analysis . ^^^ RESULTS : RT PCR analysis showed strong expression levels of 1 TAC , Mig , and CXCR 3 in RCC tissues and very weak or undetectable expression in normal kidney tissues . ^^^ Real time RT PCR analysis showed that expression levels of 1 TAC , Mig , and CXCR 3 in RCC tissues were 14 . 9 times greater , 30 . 3 times greater , and 9 . 9 times greater compared with the levels in the corresponding normal kidney tissues , respectively ( P < 0 . 01 ) . ^^^ Western blot analysis showed up regulation of 1 TAC , Mig , and CXCR 3 at the protein level . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| MIG secreted on RANKL treatment could stimulate the migration and adhesion of osteoclast precursors and osteoclasts that were primed to express CXCR 3 , the MIG receptor , by macrophage colony stimulating factor ( M CSF ) . ^^^ Therefore , we provide the first evidence demonstrating that RANKL stimulates the serine phosphorylation of STAT 1 through the p 38 MAPK pathway , causing MIG gene transcription and secretion , which may have a role in recruiting CXCR 3 positive osteoclast precursors and osteoclasts to bone remodeling or inflammatory sites . . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| Rat recombinant Mig displayed chemotactic properties and induced CXCR 3 internalization in CD4+ T cells . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| Expression of CXCR 3 ligands , such as monokine induced by IFN gamma ( Mig ) leads to preferential Th 1 recruitment , whereas CCR 4 ligands , thymus and activation regulated chemokine ( TARC ) or macrophage derived chemokine ( MDC ) , mediate preferential Th 2 recruitment . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| In this study , we investigated the expression of ligands for CXCR 3 ( Mig , IP 10 , and 1 TAC ) and CXCR 4 ( SDF 1 ) in the human endometrium throughout the menstrual cycle . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| Serum interleukin ( IL ) 12 and IFN gamma and the expression of IFN gamma inducible chemokines IP 10 , Mig and their receptor CXCR 3 in peripheral cells were analyzed . ^^^ An enhanced expression of IFN gamma chemokines IP 10 , Mig and CXCR 3 in patients with stable angina was also observed . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| From the gene expression profiling , CCR 4 , CCR 3 , MIG , CXCR 3 and BLC were selected for immunohistochemistry . ^^^ ALCL ( n=26 ) expressed CCR 3 , NKL ( n=20 ) expressed MIG , and AILD ( n=29 ) expressed CXCR 3 and / or BLC . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| Renal biopsies were examined by immunohistochemical staining for CXCR 3 and Mig . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| Infiltrating T cells , confined to the adventitia and intima , expressed CXCR 3 and CCR 5 , but were not recruited into the media despite production by vascular smooth muscle cells of IP 10 , Mig , 1 TAC , RANTES and MIP 1beta . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| Transcript levels of CXCR 3 and its ligands , interferon inducible protein 10 ( IP 10 ) and monokine induced by IFN gamma ( Mig ) , significantly increased between early and late time points together with expression of MIP 1alpha , regulated on activation normal T expressed and secreted protein ( RANTES ) and MCP 1 . ^^^ CONCLUSIONS : Our data suggest that CXCR 3 , with ligands IP 10 and Mig , is involved in T cell recruitment in acute islet xenograft rejection in non human primates . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| CXCR 3 positive B cells found at elevated frequency in the peripheral blood of patients with MALT lymphoma are attracted by MIG and belong to the lymphoma clone . ^^^ In MALT cases , CXCR 3 positive B lymphocytes in PB could migrate to MIG , the CXCR 3 ligand . ^^^ Immunohistochemical analysis showed that MALT lymphoma cells expressed CXCR 3 , whereas epithelial glands and / or stromal cells expressed MIG . ^^^ The findings support the theory that CXCR 3 positive B lymphocytes in PB of MALT patients belong to the lymphoma clone and migrate to MIG expressing mucosa associated lymphoid tissue . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| CXCR 3 , IP 10 , and Mig are required for CD4+ T cell recruitment during the DTH response to HSV 1 yet are independent of the mechanism for viral clearance . ^^^ CXCR 3 ligands IP 10 and Mig were elevated at the DTH site . ^^^ Furthermore , CXCR 3 ligand expression was abrogated and DTH diminished in mice unable to make IFN gamma , a potent inducer of IP 10 and Mig . ^^^ Collectively , these results suggest that in the sensitized host , CXCR 3 , IP 10 , and Mig are required for optimal DTH responsiveness but are not essential for containing HSV 1 replication in the ear pinna . . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| Bronchoscopic PPD challenge of skin test positive subjects resulted in the production of CXCR 3 ligands IFN gamma inducible protein ( IP ) 10 and monokine induced by IFN gamma ( Mig ) , but not of CCR 5 ligands macrophage inflammatory protein 1alpha and regulated upon activation , normal T cell expressed and secreted , whereas skin test negative subjects produced none of these chemokines . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| Monokine induced by gamma interferon ( MIG / CXCL9 ) has been shown to be expressed by IFN gamma stimulated mononuclear cells and to attract activated T cells through the chemokine receptor CXCR 3 . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| However , the CXCR 3 ligand , Mig , did not affect the migration or invasiveness of CXCR 3 positive cells . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| Accumulation of CXCR 3 expressing eosinophils and increased concentration of its ligands ( IP 10 and Mig ) in bronchoalveolar lavage fluid of patients with chronic eosinophilic pneumonia . ^^^ BACKGROUND : Since human peripheral eosinophils have been shown to migrate to the CXC chemokine receptor 3 ( CXCR 3 ) ligands IFN gamma inducible protein 10 ( IP 10 ) and monokine induced by IFN gamma ( Mig ) , this confirms that CXCR 3 is functionally expressed on these cells . ^^^ To examine the contribution of IP 10 and Mig in the pathogenesis of CEP , we measured the concentration of IP 10 and Mig , and evaluated the expression of CXCR 3 on eosinophils in BALF taken from patients with CEP . ^^^ CONCLUSIONS : Our findings suggest that IP 10 and Mig contribute to the accumulation of CXCR 3 expressing eosinophils in the lungs of patients with CEP , and modulate the eosinophilic inflammation of the lung . . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| The expression of MIG was correlated with that of MUM 1 in B CLL cell lines , and treatment with neutralizing antibodies against MIG and its receptor , CXCR 3 , slightly inhibited the proliferation of two MUM 1 expressing lines . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| Specimens with inner media infiltration displayed robust production of IFN gamma , induction of the IFN gamma inducible chemokines IP 10 and Mig , and recruitment of lymphocytes bearing their cognate receptor CXCR 3 . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : Ligands for CXCR 3 chemokines [ IFN gamma inducible protein of 10 kD ( IP 10 / CXCL10 ) , monokine induced by IFN gamma ( Mig / CXCL9 ) , IFN inducible T cell alpha chemoattractant ( 1 TAC / CXCL11 ) ] and those for CCR 4 [ macrophage derived chemokine ( MDC / CCL22 ) , thymus and activation regulated chemokine ( TARC / CCL17 ) ] have been shown to play the central roles for T helper cell recruitment into the tissues . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| This study compared the potency and efficacy of three CXCR 3 ligands , 1 TAC / CXCL11 , IP 10 / CXCL10 , and Mig / CXCL9 , as inducers of chemotaxis in HAEC and examined the underlying signaling pathways involved . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| This study further elucidates the roles of selected chemokines ( IP 10 , MIG , and RANTES ) and their receptors ( CCR 3 , CCR 5 , and CXCR 3 ) in asthma . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVES : To investigate tissue samples from patients with CD30+ CLPD for the expression of the chemokine receptors CXCR 3 , CCR 4 and CCR 3 and their ligands MIG , TARC and RANTES . ^^^ We also found that LyP cells expressed CXCR 3 , which might support their migration towards the CXCR 3 ligand MIG , which is expressed in stromal cells of the skin . . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemistry showed that the degree of CXCR 3 positive cell infiltration significantly correlated with IFN gamma inducible protein 10 , MIG and IFN gamma inducible T cell a chemoattractant expression ( 1 TAC ) . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| We investigated the effects of heparin on the IFN gamma inducible chemokines IP 10 / CXCL10 , 1 TAC / CXCL11 , and Mig / CXCL9 , which play important roles in the vascular recruitment of IFN gamma producing Th 1 cells through interactions with their cognate receptor , CXCR 3 . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| Tissue slides were stained for a variety of cell markers ( CD 3 , CD 4 , CD 8 , CD 20 , CD 68 , CD79a ) , chemokines ( monokine induced by interferon [ MIG ] , interferon inducible protein 10 [ IP 10 ] , interferon inducible T cell alpha chemoattractant [ ITAC ] , RANTES [ regulated on activation normal T cell expressed and secreted ] , and fractalkine ) , and chemokine receptors ( CXCR 3 , CCR 5 , and CX3CR1 ) . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| This novel chemokine , referred to as 1 TAC ( interferon inducible T cell alpha chemoattractant ) , is regulated by interferon ( IFN ) and has potent chemoattractant activity for interleukin ( IL ) 2 activated T cells , but not for freshly isolated unstimulated T cells , neutrophils , or monocytes . 1 TAC interacts selectively with CXCR 3 , which is the receptor for two other IFN inducible chemokines , the IFN gamma inducible 10 kD protein ( IP 10 ) and IFN gamma induced human monokine ( HuMig ) , but with a significantly higher affinity . ^^^ In addition , higher potency and efficacy of 1 TAC over IP 10 and HuMig is demonstrated by transient mobilization of intracellular calcium as well as chemotactic migration in both activated T cells and transfected cell lines expressing CXCR 3 . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| Tumor derived lymphocytes showed strong chemotactic responses to both CC and CXC chemokines in vitro and expressed high levels of CXCR 3 ( HuMig and IP 10 receptor ) and CCR 5 ( RANTES , MIP 1alpha , and MIP 1beta receptor ) . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| IFNbeta markedly upregulated CXCR 3 ligand chemokines ( SCYB 11 , SCYB 10 and SCYB 9 ) chiefly active on effector T helper type 1 ( Th 1 ) T cells , and CCR 2 ligand chemokines ( SCYA 8 and SCYA 2 ) effective on monocytes , whereas it downregulated CXCR 2 ligand chemokines ( SCYB 2 , SCYB 1 and IL 8 ) primarily active on neutrophils . ^^^ |
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| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| Therefore , MIG antiserum or CXCR 3 antiserum was administered to the rat skin engrafted mice every other day until rejection . ^^^ RESULTS : Compared with the control normal rabbit serum treated mice , either the MIG antiserum or CXCR 3 antiserum treated mice showed a delayed rejection of approximately 2 days ( 8 . 3 + / 0 . 5 days vs . 10 . 6 + / 0 . 5 days or 10 . 8 + / 1 . 9 days , respectively , P < 0 . 05 ) . ^^^ |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07325 and P49682 |
Pubmed |
SVM Score :0.0 |
| NA |
|