| Interacting proteins: Q07011 and Q96L50 |
Pubmed |
SVM Score :0.0 |
| A novel leucine rich repeat protein ( LRR 1 ) : potential involvement in 4 1BB mediated signal transduction . 4 1BB , a member of the tumor necrosis factor receptor ( TNFR ) superfamily , is induced on CD4+ and CD8+ T cells upon engagement of the T cell receptor ( TCR ) / CD 3 complex with the antigen bound to MHC . 4 1BB plays an important role in transmitting costimulatory signal during T cell activation . ^^^ A novel leucine rich repeat ( LRR ) containing protein , herein named LRR 1 , was found to specifically interact with the cytoplasmic domain of 4 1BB . ^^^ Overexpression of LRR 1 suppressed the activation of NF KB induced by 4 1BB or TNF receptor associated factor ( TRAF ) 2 . ^^^ In addition , LRR 1 down regulated JNK 1 activity was induced by 4 1BB . ^^^ These results indicate that LRR 1 negatively regulates the 4 1BB mediated signaling cascades which result in the activation of NF kappaB and JNK1 . . ^^^ |
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| Interacting proteins: Q96L50 and Q07011 |
Pubmed |
SVM Score :0.0 |
| A novel leucine rich repeat protein ( LRR 1 ) : potential involvement in 4 1BB mediated signal transduction . 4 1BB , a member of the tumor necrosis factor receptor ( TNFR ) superfamily , is induced on CD4+ and CD8+ T cells upon engagement of the T cell receptor ( TCR ) / CD 3 complex with the antigen bound to MHC . 4 1BB plays an important role in transmitting costimulatory signal during T cell activation . ^^^ A novel leucine rich repeat ( LRR ) containing protein , herein named LRR 1 , was found to specifically interact with the cytoplasmic domain of 4 1BB . ^^^ Overexpression of LRR 1 suppressed the activation of NF KB induced by 4 1BB or TNF receptor associated factor ( TRAF ) 2 . ^^^ In addition , LRR 1 down regulated JNK 1 activity was induced by 4 1BB . ^^^ These results indicate that LRR 1 negatively regulates the 4 1BB mediated signaling cascades which result in the activation of NF kappaB and JNK1 . . ^^^ |
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