| Interacting proteins: Q07011 and Q12933 |
Pubmed |
SVM Score :0.0 |
| The ability of both 4 1BB and Ox 40 to interact with TRAF 2 was confirmed in mammalian cells by coimmunoprecipitation studies . ^^^ While 4 1BB bound TRAF 2 and TRAF 1 , Ox 40 interacted with TRAF 3 and TRAF 2 . ^^^ |
|
| Interacting proteins: Q07011 and Q12933 |
Pubmed |
SVM Score :0.0 |
| Human 4 1BB ( CD 137 ) signals are mediated by TRAF 2 and activate nuclear factor kappa B . ^^^ We found that tumor necrosis factor receptor associated factor ( TRAF ) 1 , TRAF 2 , and TRAF 3 , all interacted with the cytoplasmic domain of 4 1BB . ^^^ Mutation analysis showed that TRAF 1 , TRAF 2 , and TRAF 3 were associated with one of two runs of acidic residues found in the cytoplasmic domain of 4 1BB . ^^^ In addition , 4 1BB cross linking with TCR signal in Jurkat cells and overexpression of 4 1BB in 293 cells were able to induce activation of the nuclear factor kappa B ( NF kappa B ) . 4 1BB mediated NF kappa B activation was inhibited by a dominant negative TRAF 2 or NF kappa B inducing kinase ( NIK ) . ^^^ |
|
| Interacting proteins: Q07011 and Q12933 |
Pubmed |
SVM Score :0.0 |
| CD 28 independent , TRAF 2 dependent costimulation of resting T cells by 4 1BB ligand . 4 1BB ligand ( 4 1BBL ) is a member of the tumor necrosis factor ( TNF ) family expressed on activated antigen presenting cells . ^^^ We find that TNF receptor associated factor ( TRAF ) 1 or TRAF 2 associate with a glutathione S transferase 4 1BB cytoplasmic domain fusion protein in vitro . ^^^ In T cells , we find that association of TRAF 1 and TRAF 2 with 4 1BB requires 4 1BB cross linking . ^^^ In support of a functional role for TRAF 2 in 4 1BB signaling , we find that resting T cells isolated from TRAF 2 deficient mice or from mice expressing a dominant negative form of TRAF 2 fail to augment IL 2 production in response to soluble 4 1BBL . ^^^ Thus 4 1BB , via the TRAF 2 molecule , can provide CD 28 independent costimulatory signals to resting T cells . . ^^^ |
|
| Interacting proteins: Q07011 and Q12933 |
Pubmed |
SVM Score :0.0 |
| Crystal structures of the TRAF domain of human TRAF 2 in complex with peptides from the TNFR family members CD 40 , CD 30 , Ox 40 , 4 1BB , and the EBV oncoprotein LMP 1 revealed a conserved binding mode . ^^^ |
|
| Interacting proteins: Q07011 and Q12933 |
Pubmed |
SVM Score :0.0 |
| In this study , using isothermal titration calorimetry ( ITC ) , we report thermodynamic characterization of the interaction between TRAF 2 and monomeric peptide sequences from TNFR members , including TNFR 2 , CD 40 , CD 30 , Ox 40 , and 4 1BB , and the Epstein Barr virus ( EBV ) transforming protein , latent infection membrane protein 1 ( LMP 1 ) . ^^^ |
|
| Interacting proteins: Q07011 and Q12933 |
Pubmed |
SVM Score :0.0 |
| Role of TNF receptor associated factor 2 and p 38 mitogen activated protein kinase activation during 4 1BB dependent immune response . 4 1BB is a costimulatory member of the TNFR family , expressed on activated CD 4 ( + ) and CD 8 ( + ) T cells . ^^^ Previous results showed that 4 1BB mediated T cell costimulation is CD 28 independent and involves recruitment of TNFR associated factor 2 ( TRAF 2 ) and activation of the stress activated protein kinase cascade . ^^^ T cells from TRAF 2 dominant negative mice are impaired in 4 1BB mediated p 38 MAPK activation . ^^^ |
|
| Interacting proteins: Q07011 and Q12933 |
Pubmed |
SVM Score :0.0 |
| Cross linking 4 1BBL with immobilized 4 1BB Fc also dramatically reduced the number of tartrate resistant acid phosphatase ( TRAP ) positive multinuclear cells ( MNC ) derived from the BMM from 4 1BB deficient mice , suggesting that the inhibitory effect of immobilized 4 1BB on osteoclastogenesis is due to a signal through 4 1BBL . ^^^ |
|
| Interacting proteins: Q07011 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07011 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07011 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07011 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|