| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.95418357 |
| Interactions between 4 1BB and its ligand , 4 1BBL , enhance CD 8 ( + ) T cell mediated antiviral and antitumor immunity in vivo . 0.95418357^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.66356023 |
| Crosslinking of 4 1BB evoked an antigen specific , active suppression mechanism that differed from the results of blocking the interaction between 4 1BB and its ligand , 4 1BBL . 0.66356023^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| The gene for 4 1BB ligand maps to mouse chromosome 17 , but considerably distal to the tumor necrosis factor and lymphotoxin genes . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| Expression of the epitope detected by this monoclonal antibody correlates with the induction of the costimulatory activity , and the molecule recognized by the monoclonal antibody is a single chain of around 85 kDa , distinct from B 7 1 , B 7 2 , ICAM 1 , ICAM 2 , ICAM 3 , HSA CD 5 , integrin and 4 1BB ligand . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| Costimulation of CD 28 T lymphocytes by 4 1BB ligand . ^^^ In this work , we show that T cells purified from CD 28 mice respond to B lymphomas expressing 4 1BB ligand ( 4 1BBL ) , a member of the TNF gene family . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| Role of IL 12 and 4 1BB ligand in cytokine production by CD28+ and CD 28 T cells . ^^^ IL 4 production by CD28+ or CD 28 T cells responding to B 7 ( low ) B lymphomas was abrogated by blocking 4 1BB ligand 4 1BB interaction . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| Amplification of tumor immunity by gene transfer of the co stimulatory 4 1BB ligand : synergy with the CD 28 co stimulatory pathway . ^^^ We have explored the role of an activation induced T cell molecule , 4 1BB ( CDw 137 ) , in the amplification of tumor immunity by retrovirus mediated transduction of the 4 1BB ligand ( 4 1BBL ) into tumor cells . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| This protein was used in immunohistochemical studies to identify tissues that express the 4 1BB ligand . 4 1BB Rg bound to virtually all tissues examined , suggesting that extracellular components might function as its ligands . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| Role of 4 1BB ligand in costimulation of T lymphocyte growth and its upregulation on M 12 B lymphomas by cAMP . ^^^ In this paper we report that this costimulatory activity is mediated at least in part by 4 1BB ligand , a member of the tumor necrosis factor ( TNF ) gene family that binds to 4 1BB , a T cell activation antigen with homology to the TNF / nerve growth factor receptor family . ^^^ When the antigen presenting cells express B 7 molecules as well as 4 1BB ligand , we find that B 7 molecules and 4 1BB AP both contribute to T cell activation . ^^^ These data suggest that 4 1BB ligand plays an important role in costimulation of IL 2 production and proliferation by T cells . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| CD 28 independent , TRAF 2 dependent costimulation of resting T cells by 4 1BB ligand . 4 1BB ligand ( 4 1BBL ) is a member of the tumor necrosis factor ( TNF ) family expressed on activated antigen presenting cells . ^^^ However , when 4 1BB ligand is provided together with strong TCR signals , then 4 1BBL and anti CD 28 are equally potent in stimulation of IL 2 production by resting T cells . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| The 4 1BB ( CDw 137 ) T cell molecule is a member of the TNF receptor family and triggering by either 4 1BB ligand or antibody ligation induces T cell activation and growth . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| Analysis of 4 1BB ligand ( 4 1BBL ) deficient mice and of mice lacking both 4 1BBL and CD 28 reveals a role for 4 1BBL in skin allograft rejection and in the cytotoxic T cell response to influenza virus . 4 1BB ligand ( 4 1BBL ) is a member of the TNF family expressed on activated APC . 4 1BBL binds to 4 1BB ( CD 137 ) on activated CD 4 and CD 8 T cells and in conjunction with strong signals through the TCR provides a CD 28 independent costimulatory signal leading to high level IL 2 production by primary resting T cells . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| BB ligand , a member of the TNF family , is important for the generation of antiviral CD 8 T cell responses . 4 1BB ( CD 137 ) is a costimulatory molecule expressed on activated T cells and interacts with 4 1BB ligand ( 4 1BBL ) on APCs . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| Co stimulation of antigen specific CD 4 T cells by 4 1BB ligand . 4 1BB is a member of the TNF receptor family predominantly expressed on activated T cells , and binds an inducible ligand found on B cells , macrophages and dendritic cells . ^^^ Using pigeon cytochrome c presenting fibroblast antigen presenting cells transfected with 4 1BB ligand ( 4 1BBL ) , we show that engaging 4 1BB on naive CD 4 cells promotes proliferation , cell cycle progression and IL 2 secretion , and suppresses cell death , all to a similar extent as B 7 1 engagement of CD 28 . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| Immunomodulatory gene therapy with interleukin 12 and 4 1BB ligand : long term remission of liver metastases in a mouse model . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| Expression of co stimulatory 4 1BB ligand induces significant tumor regression and protective immunity . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| Now , since mice deficient in 4 1BB or the 4 1BB ligand are available , subtle roles played by 4 1BB may be revealed in the near future . . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| Expression of 4 1BB ligand ( 4 1BBL ) mRNA was detected by both RT PCR and Northern blot analysis , and expression of 4 1BBL protein was detected by Western blot analysis of whole cell lysates and by FACS analysis of tumor cells and cell lines . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| Aggregation of 4 1BB alone induces p 38 activation in a T cell hybridoma , whereas , in normal T cells , p 38 MAPK is activated synergistically by immobilized anti CD 3 plus immobilized 4 1BB ligand . 4 1BB induced p 38 MAPK activation is inhibited by the p 38 specific inhibitor SB 203580 in both a T cell hybridoma and in murine T cells . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| Tumour rejection by gene transfer of 4 1BB ligand into a CD 80 ( + ) murine squamous cell carcinoma and the requirements of co stimulatory molecules on tumour and host cells . ^^^ We examined the effect of gene transfer of the 4 1BB ligand ( 4 1BBL ) into NRS 1 cells . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| Although some reports have suggested that 4 1BB is primarily involved in CD 8 T cell activation , in this report we demonstrate that both CD 4 and CD 8 T cells respond to 4 1BB ligand ( 4 1BBL ) with similar efficacy . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| Here , we define the molecular genetics of the human LIGHT locus , revealing its close linkage to the TNF superfamily members CD 27 ligand and 4 1BB ligand , and the third complement protein ( C 3 ) , which positions LIGHT within the MHC paralog on chromosome 19p13 . 3 . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| These genes included the tumor necrosis factor family 4 1BB ligand , ephrin B 1 , stra 6 , autotaxin , and ISLR . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| Expression and function of 4 1BB and 4 1BB ligand on murine dendritic cells . 4 1BB ( CDw 137 ) and its ligand ( 4 1BBL ) have been implicated in cellular immune responses . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| Temporal segregation of 4 1BB versus CD 28 mediated costimulation : 4 1BB ligand influences T cell numbers late in the primary response and regulates the size of the T cell memory response following influenza infection . ^^^ In this report , we demonstrate that CD 28 ( / ) mice are severely impaired in the initial expansion of D ( b ) / NP366 374 specific CD 8 T cells in response to influenza virus infection , whereas 4 1BB ligand ( 4 1BBL ) ( / ) mice show no defect in primary T cell expansion to influenza virus . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| T cell activation with systemic agonistic antibody versus local 4 1BB ligand gene delivery combined with interleukin 12 eradicate liver metastases of breast cancer . ^^^ In this study , we compared the effect of a systemically delivered agonistic anti 4 1BB monoclonal antibody ( anti 4 1BB mAb ) with intra tumoral adenoviral mediated gene transfer of the 4 1BB ligand ( ADV / 4 1BBL ) to liver metastases in a syngeneic animal model of breast cancer . ^^^ The anti tumor immunity is mainly mediated by CD4+ T cells in IL 12 plus 4 1BB ligand treated animals , and CD8+ T cells in IL 12 plus anti 4 1BB mAb treated animals . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| Thus , 4 1BB ligand ( L ) , APRIL , CD27L , CD40L , FasL , LIGHT , TRAIL receptor 4 were upregulated , while TRAIL receptor 3 was downregulated . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| For maintenance and full expansion of CTL , interaction of the DC expressed 4 1BB ligand with its receptor 4 1BB on CTL is also important . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| The interaction of 4 1BB and 4 1BB ligand provides a costimulatory signal leading to T cell activation . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| Initially , scientific interest in the 4 1BB / 4 1BB Ligand system focused on the role of the 4 1BB ( CD 137 ) receptor in the costimulation of T cells . ^^^ In this review we discuss the functional properties of 4 1BB Ligand such as its preference for CD 8 positive T cells and the differences to costimulation via the B7 / CD28 system . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| BB ( CD 137 ) differentially regulates murine in vivo protein and polysaccharide specific immunoglobulin isotype responses to Streptococcus pneumoniae . 4 1BB ( CD 137 ) is induced on activated CD 4 ( + ) and CD 8 ( + ) T cells and delivers a costimulatory signal upon binding the 4 1BB ligand ( 4 1BBL ) expressed on antigen presenting cells . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| We investigated whether 4 1BB ligand ( 4 1BBL ) , a member of the tumor necrosis factor ( TNF ) family , is involved in the maturation process to mature myeloid DCs during in vitro DC differentiation from immature DCs derived from human umbilical cord blood ( CB ) CD 34 ( + ) progenitor cells . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| A novel adenovirus expressing human 4 1BB ligand enhances antitumor immunity . 4 1BB ligand ( 4 1BBL ) , a member of the tumor necrosis factor ( TNF ) superfamily , interacts with 4 1BB ( CDw 137 ) expressed on activated T cells and delivers a costimulatory signal for T cell activation and growth . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| Provision of 4 1BB ligand enhances effector and memory CTL responses generated by immunization with dendritic cells expressing a human tumor associated antigen . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| Costimulation of human CD 28 T cells by 4 1BB ligand . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| NF kappaB and AP 1 regulate activation dependent CD 137 ( 4 1BB ) expression in T cells . 4 1BB ( CD 137 ) is a member of the tumor necrosis factor receptor superfamily and provides a costimulatory signal by interaction with 4 1BB ligand expressed on antigen presenting cells . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| Although treatment of the HeLaTR cells with T 3 did not induce expression of NF kappaB reporter luciferase , even in the presence of the 4 1BB Ligand , it increased the caspase activities . ^^^ An increase in the caspase activities was also observed in the HeLaTR cells transfected with 4 1BB cDNA , and the 4 1BB Ligand further increased the caspase activities of the HeLaTR cells overexpressing the 4 1BB . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| Blocking 4 1BB / 4 1BB ligand interactions prevents herpetic stromal keratitis . ^^^ We used the murine model of HSK to demonstrate the importance of the interaction between an inducible T cell costimulatory receptor , 4 1BB , and its ligand , 4 1BB ligand ( 4 1BBL ) , in the development of this disease . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| Tumor expression of 4 1BB ligand sustains tumor lytic T cells . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| Role of 4 1BB : 4 1BB ligand in cancer immunotherapy . ^^^ These include the more recently described 4 1BB : 4 1BB ligand ( 4 1BBL ) molecules . 4 1BB : 4 1BBL are a member of the TNFR : TNF ligand family , which are expressed on T cells and antigen presenting cells ( APCs ) , respectively . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| A functional anti human 4 1BB ligand monoclonal antibody that enhances proliferation of monocytes by reverse signaling of 4 1BBL . 4 1BB Ligand ( 4 1BBL ) , a transmembrane molecule , member of the tumor necrosis factor ligand superfamily , is an important costimulatory molecule in the immune response . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| Lipopolysaccharide preferentially induces 4 1BB ligand expression on human monocyte derived dendritic cells . ^^^ In view of recent studies demonstrating the critical role of 4 1BB co stimulation in T cell response , it is of importance to optimize 4 1BB ligand ( 4 1BBL ) expression on human monocyte derived DCs ( MDDCs ) , the DC source of many clinical studies . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| Co stimulation via 4 1BB and its ligand 4 1BB ligand ( 4 1BB L ) plays an important role in cytotoxic and pro inflammatory immune responses . 4 1BB L is generally described on activated antigen presenting cells but there is limited information on its expression and function in human dendritic cells ( DC ) . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| Functional expression of 4 1BB ( CD 137 ) in the inflammatory tissue in Crohn ' s disease . 4 1BB ligand ( L ) expressed on antigen presenting cells ( APC ) interacts with 4 1BB , expressed on activated T cells and this interaction costimulates T cells to secrete cytokines and to proliferate . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| Blockade of 4 1BB ( CD 137 ) / 4 1BB ligand interactions increases allograft survival . ^^^ Longer transplant survival was induced by blockade of 4 1BB / 4 1BB ligand ( 4 1BBL ) interactions using an anti 4 1BBL monoclonal antibody . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| Here we show that resting tonsillar MCs , when compared with lung MCs , revealed significantly higher expression levels for CC chemokines ( CCL 3 and 4 ) , which recruit T cells , and for TNFR superfamilies ( OX 40 ligand and 4 1BB ligand ) , which induce proliferation of T cells . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| An abundance of NK cells for transduction was secured by culturing peripheral blood mononuclear cells with K 562 cells expressing the NK stimulatory molecules 4 1BB ligand and interleukin 15 , which yielded a median greater than 1000 fold expansion of CD56+CD3 cells at 3 weeks of culture , without T lymphocyte expansion . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| The systemic administration of Ig 4 1BB ligand in combination with IL 12 gene transfer eradicates hepatic colon carcinoma . ^^^ We have previously shown that the local membrane bound 4 1BB ligand and IL 12 gene transfer induced a significant antitumor response in a mouse colon carcinoma model . ^^^ In this study , we hypothesize that the systemic administration of soluble Ig 4 1BB ligand can give rise to better T cell immune activation than local gene delivery . ^^^ With potential clinical applications in mind , we further compare whether the natural 4 1BB ligand fused to mouse IgG2a ( Ig 4 1BBL ) would be as effective as the agonistic anti 4 1BB antibody . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| Functional analyses demonstrate that purified T cells from NOD congenic mice with the C57BL / 10 ( B 10 ) allele at Idd9 . 3 produce more IL 2 and proliferate more vigorously in response to anti CD 3 plus immobilized 4 1BB ligand than T cells from NOD mice with the NOD allele at Idd9 . 3 . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| Immunity to melanoma mediated by 4 1BB is associated with enhanced activity of tumour infiltrating lymphocytes . 4 1BB costimulates T cells to carry out effector functions such as eradication of established tumours . 4 1BB ( CD 137 ) is a member of the TNF receptor family , and its triggering by either 4 1BB ligand or antibody ligation induces T cell activation and growth . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| Surprisingly , wild type CD8+ memory T cells expanded normally in primed OX 40 ligand or 4 1BB ligand deficient mice . ^^^ However , when wild type memory cells were generated in OX 40 ligand or 4 1BB ligand deficient mice , their secondary expansion was impaired . ^^^ This provides the novel concept that stimulation of CD8+ T cells by OX 40 and 4 1BB ligand during priming imprints into them the capacity for secondary expansion . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| Analysis of 4 1BB ligand ( 4 1BBL ) deficient cells supported this notion . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| The interaction between 4 1BB ligand ( CD137L ) , a member of the tumor necrosis factor superfamily , and its receptor 4 1BB provides a co stimulatory signal for T lymphocyte proliferation and survival . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| Several recently identified costimulators , namely , 4 1BB ligand , ICOS ligand , and OX 40 ligand , are up regulated on cultured HDMEC in response to TNF or coculture with allogeneic T cells . ^^^ Furthermore , blocking 4 1BB ligand , ICOS ligand , or OX 40 ligand in this model reduces human skin allograft injury and T cell effector molecule expression . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| Involvement of 4 1BB ( CD 137 ) 4 1BBligand interaction in the modulation of CD 4 T cell mediated inflammatory colitis . 4 1BB ligand ( 4 1BBL ) expressed on antigen presenting cells interacts with 4 1BB on activated T cells ( especially CD8+ cells ) and co stimulates the latter to secrete cytokines and to proliferate . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| The interaction of 4 1BB and 4 1BB ligand ( 4 1BBL ) activates an important costimulatory pathway with diverse and important roles in immune regulation . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| A signal through 4 1BB ligand inhibits receptor for activation of nuclear factor kappaB ligand ( RANKL ) induced osteoclastogenesis by increasing interferon ( IFN ) beta production . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| Crystallization and preliminary 10 ray crystallographic study of the extracellular domain of the 4 1BB ligand , a member of the TNF family . ^^^ The 4 1BB ligand , a member of the tumour necrosis factor ( TNF ) family , is an important co stimulatory molecule that plays a key role in the clonal expansion and survival of CD8+ T cells . ^^^ Signalling through binding of the 4 1BB ligand and 4 1BB has been reported to enhance CD8+ T cell expansion and protect activated CD8+ T cells from death . ^^^ The 4 1BB ligand is an integral protein expressed on activated antigen presenting cells . ^^^ The extracellular domain of the 4 1BB ligand fused with glutathione S transferase was expressed in Escherichia coli ( Origami ) and purified by using affinity and ion exchange column chromatographic methods . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| This unique function of OX40L was not shared by two costimulatory TNF family members , GITR ligand and 4 1BB ligand . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| Increased soluble 4 1BB ligand ( 4 1BBL ) levels in peripheral blood of patients with multiple sclerosis . 4 1BB ligand ( 4 1BBL ; CD137L ) is a member of the tumour necrosis factor superfamily expressed primarily on antigen presenting cells such as B cells , macrophages and dendritic cells . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| A genetic linkage , as evidence for evolutionary relatedness , is found by chromosomal cluster of TNFR p 80 , CD 30 , 4 1BB , and OX 40 for 1p36 ; TNFR p 60 , TNFR RP , and CD 27 for 12p13 ; TNF , LT alpha , and LT beta for 6 ( MHC locus ) ; CD27L and 4 1BBL for 19p13 ; and FASL and OX40L for 1q25 . ^^^ However , the other family members presently have a one ligand / one receptor binding principle ( CD27 / CD27L , CD30 / CD30L , CD40 / CD40L , 4 1BB / 4 1BBL , OX40 / gp34 , and FAS / FASL ) . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| Recently , we identified and cloned a murine ligand for 4 1BB ( mu 4 1BB L ) and demonstrated it to be a member of an emerging family of ligands with structural homology to tumor necrosis factor . ^^^ To characterize further the role of 4 1BB in the immune response we undertook to clone the human homologue of 4 1BB L . ^^^ However , attempts to isolate a cDNA encoding the human 4 1BB L by cross hybridization with the murine cDNA were unsuccessful . ^^^ Fc ) was then used to identify and clone a gene for human 4 1BB L from an activated CD4+ T cell clone using a direct expression cloning strategy . ^^^ Human 4 1BB L shows 36 % amino acid identity with its murine counterpart and maps to chromosome 19p13 . 3 . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| A genetic linkage , as evidence for evolutionary relatedness , is also found by chromosomal cluster for CD 30 , CD120b , 4 1BB and OX 40 to 1p36 ; CD 27 , CD120a and TNFR RP to 12p13 ; TNF , LT alpha and LT beta to 6p21 ; CD27L and 4 1BBL to 19p13 ; CD95L and OX40L to 1q25 . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| In this study , to address the role of costimulatory molecules CD 27 , CD 30 , 4 1BB , and OX 40 , which belong to the tumor necrosis factor receptor superfamily , in the development of Th 1 and Th 2 cells in vivo , we administered monoclonal antibody ( mAb ) against their ligands , CD 70 , CD 30 ligand ( L ) , 4 1BBL , and OX40L , to mice infected with L . major . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| However , unlike the CD28 / B7 pair , 4 1BB and its ligand 4 1BBL constitute a member of the tumor necrosis factor ( TNF ) receptor / TNF pair superfamily . ^^^ To investigate whether 4 1BB takes the signaling pathways analogous to those for TNF receptors , we generated polyclonal antibodies against human 4 1BB and 4 1BBL and established stable transfectants of the receptor and the ligand with a high level of cell surface expression . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| METHODS : Vascularized heart transplantation , allogeneic mixed leukocyte reaction ( MLR ) , and graft versus host disease models were used to examine 4 1BB and 4 1BBL expression . ^^^ RESULTS : Using a heart transplant model , we found that 4 1BB and 4 1BBL transcripts were both expressed in rejecting cardiac grafts . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| Recently , a tumor necrosis factor like ligand of m 4 1BB , m 4 1BBL , as well as the human counterparts of 4 1BB ( ILA ) and 4 1BBL ( h 4 1BB and h 4 1BBL , respectively ) have been cloned . ^^^ Analysis of 4 1BBL and laminin binding to murine 4 1BB , a member of the tumor necrosis factor receptor superfamily , and comparison with human 4 1BB . ^^^ No information is currently available on how binding of m 4 1BB to ECM proteins affects its binding to m 4 1BBL and vice versa and if the ability of m 4 1BB to bind ECM proteins is conserved across species . ^^^ We report that binding of m 4 1BBL to m 4 1BB blocked its ability to bind laminin ( LN ) , while binding of m 4 1BB to LN did not block its ability to bind m 4 1BBL . ^^^ Furthermore , binding of m 4 1BBL to the m 4 1BB . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| The 4 1BB glycoprotein is a member of the tumor necrosis factor receptor superfamily and binds to a high affinity ligand ( 4 1BBL ) expressed on several antigen presenting cells such as macrophages and activated B cells . ^^^ Expression of 4 1BB is restricted to primed CD4+ and CD8+ T cells , and 4 1BB signaling either by binding to 4 1BBL or by antibody ligation delivers a dual mitogenic signal for T cell activation and growth . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| The natural ligand for 4 1BB , 4 1BBL is also induced and is found on activated antigen presenting cells . ^^^ Interference with the 4 1BB 4 1BBL pathway may be of therapeutic use in the treatment of HIV infection . 4 1BB deficient mice show dysregulated immune responses and mount elevated Ig responses to T dependent antigens . . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| In vitro blocking experiments with anti B 7 1 plus anti B 7 2 and / or soluble 4 1BB receptor showed B 7 1 , B 7 2 , and 4 1BBL all contributed to the CTL activity . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| Interaction of 4 1BB ( CD 137 ) and its ligand ( 4 1BBL ) is thought to positively regulate cell mediated and humoral immune responses . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| Soluble 4 1BBL was active in that it competed with recombinant 4 1BBL for binding to the 4 1BB receptor and was able to costimulate IL 2 and IFN gamma release from peripheral T cells . ^^^ These results indicate that the release of soluble 4 1BBL from the cell surface is mediated by one or more sheddases and likely regulates 4 1BB 4 1BBL interactions between cells in vivo . ^^^ Cleavage of 4 1BBL to an active soluble form would alter both proximal and distal cellular responses , including cell survival and costimulatory or inflammatory responses , that are mediated through the 4 1BB pathway . ^^^ Expression of CD 137 ligand ( 4 1BBL ) , a member of the TNF family of proteins , has been reported on several types of APCs , various carcinoma cells , and can be induced on activated T cells . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| Since the discovery of 4 1BB 15 years ago , the receptor and its ligand ( 4 1BBL ) have remained enigmatic molecules because of their highly regulated pattern of expression . ^^^ Recent studies highlight the participation of 4 1BB and its ligand 4 1BBL in a more complex network of immune cell responses and suggest that intervening in the 4 1BB costimulatory pathway might have some potential as a therapeutic approach to immune disorders . . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| Polyclonal CD4+ T lymphocytes can be activated and expanded using anti CD 3 and anti CD 28 antibodies presented on magnetic beads , and CD8+T lymphocytes can be successfully expanded using a novel genetically engineered cell based technology that presents anti CD 3 and anti CD 28 along with the costimulatory molecule CD 137 ( 4 1BBL ) . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| A switch in costimulation from CD 28 to 4 1BB during primary versus secondary CD 8 T cell response to influenza in vivo . 4 1BBL ( / ) mice exhibit normal primary CD 8 T cell responses to influenza virus , but show decreased CD 8 T cell numbers late in the primary response as well as decreased secondary responses . ^^^ In contrast , anti 4 1BB added during priming fails to correct the defective secondary response in 4 1BBL ( / ) mice , whereas addition of anti 4 1BB during challenge fully restores this response . ^^^ These studies rule out a model in which signals delivered through 4 1BB during priming program the T cells to give a full recall response and suggest that 4 1BB 4 1BBL interactions take place at later stages in the immune response . ^^^ The results indicate that anti 4 1BB or 4 1BBL therapy will be most effective during the boost phase of a prime boost vaccination strategy . . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| Among these costimulatory molecules , strong expression of 4 1BBL and Fas was induced in the aortic tissue , and most of the infiltrating cells expressed 4 1BB and FasL , suggesting these pathways play critical roles in T cell mediated vascular injury . ^^^ Our findings strongly suggest that 4 1BB / 4 1BBL and Fas / FasL pathways play important roles in vascular injury in Takayasu ' s arteritis . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| A panel of monoclonal antibodies specific for CD 27 ligand ( CD 70 ) , CD 30 ligand ( CD 153 ) , CD 134 ligand ( OX40L ) , and CD 137 ligand ( 4 1BBL ) were screened in vivo for their ability to affect the control of Mycobacterium avium infection in C57Bl / 6 mice . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| In addition , incubation of activated CD8+ T cells with p 815 cells expressing 4 1BBL led to redistribution of the lipid raft domains and Lck , protein kinase C theta ; , SLP 76 , and phospholipase C gamma 1 ( PLC gamma 1 ) on the T cell membranes to the areas of contact with the p 815 cells and recruitment of 4 1BB , TNFR associated factor 2 , and phospho tyrosine proteins to the raft domains . 4 1BB ligation also caused translocation of TNFR associated factor 2 , protein kinase C theta ; , PLC gamma 1 , and SLP 76 to detergent insoluble compartments in the CD8+ T cells , and cross linking of 4 1BB increased intracellular Ca2+ levels apparently by activating PLC gamma 1 . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| In this study we highlight the involvement of 4 1BB / 4 1BBL in the development of T cell responses . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| The involvement of costimulatory markers OX40 / 4 1BB / 4 1BBL leads to the enhancement of signals which are necessary for lymphocyte activation in addition to the antigen specific signal and may prevent anergy . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| Thus , it appears that 4 1BB / 4 1BBL interactions control the number of surviving CD8+ effector memory cells , late in the primary response . ^^^ These data suggest a model whereby 4 1BB expression on memory CD8+ T cells , perhaps due to encounter with IL 15 in the bone marrow , allows 4 1BB / 4 1BBL interactions to maintain memory CD 8 T cell survival in the absence of Ag . . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| This study was conducted to determine if a poxvirus expressing the ligand for 4 1BB ( 4 1BBL ) could further improve the immune and therapeutic responses of a previously reported poxvirus vaccine expressing a triad of costimulatory molecules ( B7 . 1 , ICAM 1 , and LFA 3 ) . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| Gene therapy using adenoviral vector encoding 4 1BBIg gene significantly prolonged murine cardiac allograft survival . 4 1BB , a member of the tumor necrosis factor ( TNF ) receptor superfamily , interacts with 4 1BBL expressed on APC and delivers a costimulatory signal for T cell activation and growth . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| However , inhibition of 4 1BB / 4 1BB ligand ( 4 1BBL ) interaction does not suppress the development of EAU . ^^^ It appears that cross linking of 4 1BB evokes an active antigen specific suppression mechanism rather than merely blocking 4 1BB / 4 1BBL interaction . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| The expanded CD8+ population contained more cells expressing CD 137 ( 4 1BB ) , CD 137 ( 4 1BBL ) , CD 30 ( Ki 1 ) , CD 40 and CD 134 ( OX 40 ) . ^^^ |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41273 and Q07011 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.95418357 |
| Interactions between 4 1BB and its ligand , 4 1BBL , enhance CD 8 ( + ) T cell mediated antiviral and antitumor immunity in vivo . 0.95418357^^^ |
|
| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.66356023 |
| Crosslinking of 4 1BB evoked an antigen specific , active suppression mechanism that differed from the results of blocking the interaction between 4 1BB and its ligand , 4 1BBL . 0.66356023^^^ |
|
| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| We have explored the role of an activation induced T cell molecule , 4 1BB ( CDw 137 ) , in the amplification of tumor immunity by retrovirus mediated transduction of the 4 1BB ligand ( 4 1BBL ) into tumor cells . ^^^ |
|
| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| The 4 1BB ( CDw 137 ) T cell molecule is a member of the TNF receptor family and triggering by either 4 1BB ligand or antibody ligation induces T cell activation and growth . ^^^ |
|
| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| Expression and function of 4 1BB and 4 1BB ligand on murine dendritic cells . 4 1BB ( CDw 137 ) and its ligand ( 4 1BBL ) have been implicated in cellular immune responses . ^^^ |
|
| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| This protein was used in immunohistochemical studies to identify tissues that express the 4 1BB ligand . 4 1BB Rg bound to virtually all tissues examined , suggesting that extracellular components might function as its ligands . ^^^ |
|
| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| The B lymphoma M 12 expresses low levels of 4 1BB L but can be induced to express higher levels by treatment of the B cells with cAMP , which also induces B 7 1 and B 7 2 in these cells . ^^^ Role of 4 1BB ligand in costimulation of T lymphocyte growth and its upregulation on M 12 B lymphomas by cAMP . ^^^ In this paper we report that this costimulatory activity is mediated at least in part by 4 1BB ligand , a member of the tumor necrosis factor ( TNF ) gene family that binds to 4 1BB , a T cell activation antigen with homology to the TNF / nerve growth factor receptor family . ^^^ When the antigen presenting cells express B 7 molecules as well as 4 1BB ligand , we find that B 7 molecules and 4 1BB AP both contribute to T cell activation . ^^^ These data suggest that 4 1BB ligand plays an important role in costimulation of IL 2 production and proliferation by T cells . ^^^ |
|
| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| A genetic linkage , as evidence for evolutionary relatedness , is found by chromosomal cluster of TNFR p 80 , CD 30 , 4 1BB , and OX 40 for 1p36 ; TNFR p 60 , TNFR RP , and CD 27 for 12p13 ; TNF , LT alpha , and LT beta for 6 ( MHC locus ) ; CD27L and 4 1BBL for 19p13 ; and FASL and OX40L for 1q25 . ^^^ However , the other family members presently have a one ligand / one receptor binding principle ( CD27 / CD27L , CD30 / CD30L , CD40 / CD40L , 4 1BB / 4 1BBL , OX40 / gp34 , and FAS / FASL ) . ^^^ |
|
| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| Recently , we identified and cloned a murine ligand for 4 1BB ( mu 4 1BB L ) and demonstrated it to be a member of an emerging family of ligands with structural homology to tumor necrosis factor . ^^^ To characterize further the role of 4 1BB in the immune response we undertook to clone the human homologue of 4 1BB L . ^^^ However , attempts to isolate a cDNA encoding the human 4 1BB L by cross hybridization with the murine cDNA were unsuccessful . ^^^ Fc ) was then used to identify and clone a gene for human 4 1BB L from an activated CD4+ T cell clone using a direct expression cloning strategy . ^^^ Human 4 1BB L shows 36 % amino acid identity with its murine counterpart and maps to chromosome 19p13 . 3 . ^^^ |
|
| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| The gene for 4 1BB ligand maps to mouse chromosome 17 , but considerably distal to the tumor necrosis factor and lymphotoxin genes . ^^^ |
|
| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| A novel adenovirus expressing human 4 1BB ligand enhances antitumor immunity . 4 1BB ligand ( 4 1BBL ) , a member of the tumor necrosis factor ( TNF ) superfamily , interacts with 4 1BB ( CDw 137 ) expressed on activated T cells and delivers a costimulatory signal for T cell activation and growth . ^^^ |
|
| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| Recently , a tumor necrosis factor like ligand of m 4 1BB , m 4 1BBL , as well as the human counterparts of 4 1BB ( ILA ) and 4 1BBL ( h 4 1BB and h 4 1BBL , respectively ) have been cloned . ^^^ |
|
| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| When APC express high levels of B 7 family molecules as well as 4 1BBL , soluble 4 1BB inhibits IL 4 production by CD 28 but not by CD28+ cells . ^^^ Role of IL 12 and 4 1BB ligand in cytokine production by CD28+ and CD 28 T cells . ^^^ IL 4 production by CD28+ or CD 28 T cells responding to B 7 ( low ) B lymphomas was abrogated by blocking 4 1BB ligand 4 1BB interaction . ^^^ |
|
| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| The 4 1BB glycoprotein is a member of the tumor necrosis factor receptor superfamily and binds to a high affinity ligand ( 4 1BBL ) expressed on several antigen presenting cells such as macrophages and activated B cells . ^^^ Expression of 4 1BB is restricted to primed CD4+ and CD8+ T cells , and 4 1BB signaling either by binding to 4 1BBL or by antibody ligation delivers a dual mitogenic signal for T cell activation and growth . ^^^ |
|
| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| CD 28 independent , TRAF 2 dependent costimulation of resting T cells by 4 1BB ligand . 4 1BB ligand ( 4 1BBL ) is a member of the tumor necrosis factor ( TNF ) family expressed on activated antigen presenting cells . ^^^ However , when 4 1BB ligand is provided together with strong TCR signals , then 4 1BBL and anti CD 28 are equally potent in stimulation of IL 2 production by resting T cells . ^^^ In support of a functional role for TRAF 2 in 4 1BB signaling , we find that resting T cells isolated from TRAF 2 deficient mice or from mice expressing a dominant negative form of TRAF 2 fail to augment IL 2 production in response to soluble 4 1BBL . ^^^ |
|
| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| The natural ligand for 4 1BB , 4 1BBL is also induced and is found on activated antigen presenting cells . ^^^ Interference with the 4 1BB 4 1BBL pathway may be of therapeutic use in the treatment of HIV infection . 4 1BB deficient mice show dysregulated immune responses and mount elevated Ig responses to T dependent antigens . . ^^^ |
|
| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| Expression of the epitope detected by this monoclonal antibody correlates with the induction of the costimulatory activity , and the molecule recognized by the monoclonal antibody is a single chain of around 85 kDa , distinct from B 7 1 , B 7 2 , ICAM 1 , ICAM 2 , ICAM 3 , HSA CD 5 , integrin and 4 1BB ligand . ^^^ |
|
| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| A genetic linkage , as evidence for evolutionary relatedness , is also found by chromosomal cluster for CD 30 , CD120b , 4 1BB and OX 40 to 1p36 ; CD 27 , CD120a and TNFR RP to 12p13 ; TNF , LT alpha and LT beta to 6p21 ; CD27L and 4 1BBL to 19p13 ; CD95L and OX40L to 1q25 . ^^^ |
|
| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| In this work , we show that T cells purified from CD 28 mice respond to B lymphomas expressing 4 1BB ligand ( 4 1BBL ) , a member of the TNF gene family . ^^^ This response is inhibited by a soluble form of 4 1BB , the T cell surface receptor for 4 1BBL . ^^^ Thus , 4 1BBL / 4 1BB interaction provides costimulatory signals to T cells independent of signaling through the CD 28 receptor . ^^^ Costimulation of CD 28 T lymphocytes by 4 1BB ligand . ^^^ |
|
| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| In vitro blocking experiments with anti B 7 1 plus anti B 7 2 and / or soluble 4 1BB receptor showed B 7 1 , B 7 2 , and 4 1BBL all contributed to the CTL activity . ^^^ |
|
| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| Analysis of 4 1BB ligand ( 4 1BBL ) deficient mice and of mice lacking both 4 1BBL and CD 28 reveals a role for 4 1BBL in skin allograft rejection and in the cytotoxic T cell response to influenza virus . 4 1BB ligand ( 4 1BBL ) is a member of the TNF family expressed on activated APC . 4 1BBL binds to 4 1BB ( CD 137 ) on activated CD 4 and CD 8 T cells and in conjunction with strong signals through the TCR provides a CD 28 independent costimulatory signal leading to high level IL 2 production by primary resting T cells . ^^^ In agreement with these in vivo results , allogeneic CTL responses of CD 28 / but not CD28+ / + T cells to 4 1BBL expressing APC are substantially inhibited by soluble 4 1BB receptor as is the in vitro secondary response of CD28+ T cells to influenza virus peptides . ^^^ |
|
| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| BB ligand , a member of the TNF family , is important for the generation of antiviral CD 8 T cell responses . 4 1BB ( CD 137 ) is a costimulatory molecule expressed on activated T cells and interacts with 4 1BB ligand ( 4 1BBL ) on APCs . ^^^ To investigate the role of 4 1BB costimulation for the development of primary immune responses , 4 1BBL deficient ( 4 1BBL / ) mice were infected with lymphocytic choriomeningitis virus ( LCMV ) . 4 1BBL / mice were able to generate CTL and eliminate acute LCMV infection with normal kinetics , but CD 8 T cell expansion was 2 to 3 fold lower than in wild type ( + / + ) mice . ^^^ Altogether , these results indicate that T cells have distinct costimulatory requirements : optimal CD 8 responses require 4 1BBL dependent interactions , whereas CD 4 responses are minimally affected by 4 1BB costimulation , but require CD 40 CD40L and B 7 dependent interactions . . ^^^ |
|
| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| In this study , to address the role of costimulatory molecules CD 27 , CD 30 , 4 1BB , and OX 40 , which belong to the tumor necrosis factor receptor superfamily , in the development of Th 1 and Th 2 cells in vivo , we administered monoclonal antibody ( mAb ) against their ligands , CD 70 , CD 30 ligand ( L ) , 4 1BBL , and OX40L , to mice infected with L . major . ^^^ |
|
| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| Interaction of 4 1BB with its natural ligand ( 4 1BBL ) has been shown to amplify T cell ( especially CD8+ ) mediated immunity . ^^^ Immunomodulatory gene therapy with interleukin 12 and 4 1BB ligand : long term remission of liver metastases in a mouse model . ^^^ |
|
| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| Expression of co stimulatory 4 1BB ligand induces significant tumor regression and protective immunity . ^^^ |
|
| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| Now , since mice deficient in 4 1BB or the 4 1BB ligand are available , subtle roles played by 4 1BB may be revealed in the near future . . ^^^ |
|
| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| However , unlike the CD28 / B7 pair , 4 1BB and its ligand 4 1BBL constitute a member of the tumor necrosis factor ( TNF ) receptor / TNF pair superfamily . ^^^ To investigate whether 4 1BB takes the signaling pathways analogous to those for TNF receptors , we generated polyclonal antibodies against human 4 1BB and 4 1BBL and established stable transfectants of the receptor and the ligand with a high level of cell surface expression . ^^^ |
|
| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| METHODS : Vascularized heart transplantation , allogeneic mixed leukocyte reaction ( MLR ) , and graft versus host disease models were used to examine 4 1BB and 4 1BBL expression . ^^^ RESULTS : Using a heart transplant model , we found that 4 1BB and 4 1BBL transcripts were both expressed in rejecting cardiac grafts . ^^^ |
|
| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| Expression of 4 1BB ligand ( 4 1BBL ) mRNA was detected by both RT PCR and Northern blot analysis , and expression of 4 1BBL protein was detected by Western blot analysis of whole cell lysates and by FACS analysis of tumor cells and cell lines . ^^^ Incubation of tumor cells with a 4 1BB Ig fusion protein led to the production of IL 8 by the cells , demonstrating that the 4 1BBL is functionally active and signals back into the tumor cells . ^^^ |
|
| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| Using pigeon cytochrome c presenting fibroblast antigen presenting cells transfected with 4 1BB ligand ( 4 1BBL ) , we show that engaging 4 1BB on naive CD 4 cells promotes proliferation , cell cycle progression and IL 2 secretion , and suppresses cell death , all to a similar extent as B 7 1 engagement of CD 28 . ^^^ In addition , 4 1BBL synergizes with B 7 and ICAM to enhance naive CD 4 proliferation when antigen is limiting . 4 1BBL alone , and to a greater extent with B 7 , also augmented IL 2 secretion resting antigen experienced CD 4 cells , as typified by T helper clones , whereas short term effector cells showed similar levels of proliferation and cytokine secretion regardless of whether 4 1BB was engaged . ^^^ Blocking studies with activated B cells presenting antigen showed that 4 1BB participates in promoting IL 2 production by resting CD 4 cells , confirming that 4 1BBL can play a role in antigen specific CD 4 T cell responses . . ^^^ Co stimulation of antigen specific CD 4 T cells by 4 1BB ligand . 4 1BB is a member of the TNF receptor family predominantly expressed on activated T cells , and binds an inducible ligand found on B cells , macrophages and dendritic cells . ^^^ |
|
| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| Interaction of 4 1BB ( CD 137 ) and its ligand ( 4 1BBL ) is thought to positively regulate cell mediated and humoral immune responses . ^^^ |
|
| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| Soluble 4 1BBL was active in that it competed with recombinant 4 1BBL for binding to the 4 1BB receptor and was able to costimulate IL 2 and IFN gamma release from peripheral T cells . ^^^ These results indicate that the release of soluble 4 1BBL from the cell surface is mediated by one or more sheddases and likely regulates 4 1BB 4 1BBL interactions between cells in vivo . ^^^ Cleavage of 4 1BBL to an active soluble form would alter both proximal and distal cellular responses , including cell survival and costimulatory or inflammatory responses , that are mediated through the 4 1BB pathway . ^^^ |
|
| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| Here , we define the molecular genetics of the human LIGHT locus , revealing its close linkage to the TNF superfamily members CD 27 ligand and 4 1BB ligand , and the third complement protein ( C 3 ) , which positions LIGHT within the MHC paralog on chromosome 19p13 . 3 . ^^^ |
|
| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| These genes included the tumor necrosis factor family 4 1BB ligand , ephrin B 1 , stra 6 , autotaxin , and ISLR . ^^^ |
|
| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| Aggregation of 4 1BB alone induces p 38 activation in a T cell hybridoma , whereas , in normal T cells , p 38 MAPK is activated synergistically by immobilized anti CD 3 plus immobilized 4 1BB ligand . 4 1BB induced p 38 MAPK activation is inhibited by the p 38 specific inhibitor SB 203580 in both a T cell hybridoma and in murine T cells . ^^^ |
|
| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| We examined the effect of gene transfer of the 4 1BB ligand ( 4 1BBL ) into NRS 1 cells . ^^^ Tumour rejection by gene transfer of 4 1BB ligand into a CD 80 ( + ) murine squamous cell carcinoma and the requirements of co stimulatory molecules on tumour and host cells . ^^^ |
|
| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| Although some reports have suggested that 4 1BB is primarily involved in CD 8 T cell activation , in this report we demonstrate that both CD 4 and CD 8 T cells respond to 4 1BB ligand ( 4 1BBL ) with similar efficacy . ^^^ CD 4 and CD 8 TCR transgenic T cells up regulate 4 1BB , OX 40 , and CD 27 and respond to 4 1BBL mediated costimulation during a primary response to peptide Ag . 4 1BBL enhanced proliferation , cytokine production , and CTL effector function of TCR transgenic T cells . ^^^ These data support the idea that CD 28 plays a primary role in initial T cell expansion , whereas 4 1BB / 4 1BBL sustains both CD 4 and CD 8 T cell responses , as well as enhances cell division and T cell effector function . . ^^^ |
|
| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| In this report , we demonstrate that CD 28 ( / ) mice are severely impaired in the initial expansion of D ( b ) / NP366 374 specific CD 8 T cells in response to influenza virus infection , whereas 4 1BB ligand ( 4 1BBL ) ( / ) mice show no defect in primary T cell expansion to influenza virus . ^^^ Thus , CD 28 is critical for initial T cell expansion , whereas 4 1BB / 4 1BBL signaling affects T cell numbers much later in the response and is essential for the survival and / or responsiveness of the memory CD 8 T cell pool . . ^^^ Temporal segregation of 4 1BB versus CD 28 mediated costimulation : 4 1BB ligand influences T cell numbers late in the primary response and regulates the size of the T cell memory response following influenza infection . ^^^ |
|
| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| In this study , we compared the effect of a systemically delivered agonistic anti 4 1BB monoclonal antibody ( anti 4 1BB mAb ) with intra tumoral adenoviral mediated gene transfer of the 4 1BB ligand ( ADV / 4 1BBL ) to liver metastases in a syngeneic animal model of breast cancer . ^^^ When combined with intra tumoral delivery of the IL 12 gene , both anti 4 1BB mAb and ADV / 4 1BBL were synergistic and led to survival rates of 87 % and 78 % , respectively . ^^^ T cell activation with systemic agonistic antibody versus local 4 1BB ligand gene delivery combined with interleukin 12 eradicate liver metastases of breast cancer . ^^^ The anti tumor immunity is mainly mediated by CD4+ T cells in IL 12 plus 4 1BB ligand treated animals , and CD8+ T cells in IL 12 plus anti 4 1BB mAb treated animals . ^^^ |
|
| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| Thus , 4 1BB ligand ( L ) , APRIL , CD27L , CD40L , FasL , LIGHT , TRAIL receptor 4 were upregulated , while TRAIL receptor 3 was downregulated . ^^^ |
|
| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| Since the discovery of 4 1BB 15 years ago , the receptor and its ligand ( 4 1BBL ) have remained enigmatic molecules because of their highly regulated pattern of expression . ^^^ Recent studies highlight the participation of 4 1BB and its ligand 4 1BBL in a more complex network of immune cell responses and suggest that intervening in the 4 1BB costimulatory pathway might have some potential as a therapeutic approach to immune disorders . . ^^^ |
|
| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| For maintenance and full expansion of CTL , interaction of the DC expressed 4 1BB ligand with its receptor 4 1BB on CTL is also important . ^^^ |
|
| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| The interaction of 4 1BB and 4 1BB ligand provides a costimulatory signal leading to T cell activation . ^^^ |
|
| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| Initially , scientific interest in the 4 1BB / 4 1BB Ligand system focused on the role of the 4 1BB ( CD 137 ) receptor in the costimulation of T cells . ^^^ In this review we discuss the functional properties of 4 1BB Ligand such as its preference for CD 8 positive T cells and the differences to costimulation via the B7 / CD28 system . ^^^ |
|
| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| BB ( CD 137 ) differentially regulates murine in vivo protein and polysaccharide specific immunoglobulin isotype responses to Streptococcus pneumoniae . 4 1BB ( CD 137 ) is induced on activated CD 4 ( + ) and CD 8 ( + ) T cells and delivers a costimulatory signal upon binding the 4 1BB ligand ( 4 1BBL ) expressed on antigen presenting cells . ^^^ These data are the first to suggest a stimulatory role for endogenous 4 1BB 4 1BBL interactions during a humoral immune response to a pathogen and further underscore significant differences in costimulation requirements for an in vivo protein versus polysaccharide specific Ig isotype response to an extracellular bacterium . . ^^^ |
|
| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| We investigated whether 4 1BB ligand ( 4 1BBL ) , a member of the tumor necrosis factor ( TNF ) family , is involved in the maturation process to mature myeloid DCs during in vitro DC differentiation from immature DCs derived from human umbilical cord blood ( CB ) CD 34 ( + ) progenitor cells . ^^^ Stimulation of 4 1BBL on DCs with 4 1BB Fc or with 4 1BB transfected Jurkat cells resulted in acquisition of capacity for the immature DCs to produce interleukin 12 ( IL 12 ) . ^^^ |
|
| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| Provision of 4 1BB ligand enhances effector and memory CTL responses generated by immunization with dendritic cells expressing a human tumor associated antigen . ^^^ |
|
| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| Costimulation of human CD 28 T cells by 4 1BB ligand . ^^^ |
|
| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| NF kappaB and AP 1 regulate activation dependent CD 137 ( 4 1BB ) expression in T cells . 4 1BB ( CD 137 ) is a member of the tumor necrosis factor receptor superfamily and provides a costimulatory signal by interaction with 4 1BB ligand expressed on antigen presenting cells . ^^^ |
|
| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| Although treatment of the HeLaTR cells with T 3 did not induce expression of NF kappaB reporter luciferase , even in the presence of the 4 1BB Ligand , it increased the caspase activities . ^^^ An increase in the caspase activities was also observed in the HeLaTR cells transfected with 4 1BB cDNA , and the 4 1BB Ligand further increased the caspase activities of the HeLaTR cells overexpressing the 4 1BB . ^^^ |
|
| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| We used the murine model of HSK to demonstrate the importance of the interaction between an inducible T cell costimulatory receptor , 4 1BB , and its ligand , 4 1BB ligand ( 4 1BBL ) , in the development of this disease . ^^^ In BALB / c mice , HSK ordinarily induced by infection with the RE strain of herpes was prevented by blocking 4 1BB / 4 1BBL interaction , either by deleting 4 1BB ( in mutant 4 1BB ( / ) mice ) or by introducing mAbs against 4 1BBL . ^^^ Blocking 4 1BB / 4 1BB ligand interactions prevents herpetic stromal keratitis . ^^^ |
|
| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| Tumor expression of 4 1BB ligand sustains tumor lytic T cells . ^^^ |
|
| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| In view of recent studies demonstrating the critical role of 4 1BB co stimulation in T cell response , it is of importance to optimize 4 1BB ligand ( 4 1BBL ) expression on human monocyte derived DCs ( MDDCs ) , the DC source of many clinical studies . ^^^ Lipopolysaccharide preferentially induces 4 1BB ligand expression on human monocyte derived dendritic cells . ^^^ |
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| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| A switch in costimulation from CD 28 to 4 1BB during primary versus secondary CD 8 T cell response to influenza in vivo . 4 1BBL ( / ) mice exhibit normal primary CD 8 T cell responses to influenza virus , but show decreased CD 8 T cell numbers late in the primary response as well as decreased secondary responses . ^^^ In contrast , anti 4 1BB added during priming fails to correct the defective secondary response in 4 1BBL ( / ) mice , whereas addition of anti 4 1BB during challenge fully restores this response . ^^^ These studies rule out a model in which signals delivered through 4 1BB during priming program the T cells to give a full recall response and suggest that 4 1BB 4 1BBL interactions take place at later stages in the immune response . ^^^ The results indicate that anti 4 1BB or 4 1BBL therapy will be most effective during the boost phase of a prime boost vaccination strategy . . ^^^ |
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| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| These include the more recently described 4 1BB : 4 1BB ligand ( 4 1BBL ) molecules . 4 1BB : 4 1BBL are a member of the TNFR : TNF ligand family , which are expressed on T cells and antigen presenting cells ( APCs ) , respectively . ^^^ Therapies utilizing the 4 1BB : 4 1BBL signaling pathway have been shown to have antitumor effects in a number of model systems . ^^^ In this paper , we focus on the 4 1BB : 4 1BBL costimulatory molecules . ^^^ In particular , we will describe the structure and function of the 4 1BB molecule , its receptor and how 4 1BB : 4 1BBL costimulation has and may be used for the immunotherapy of cancer . . ^^^ Role of 4 1BB : 4 1BB ligand in cancer immunotherapy . ^^^ |
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| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| A functional anti human 4 1BB ligand monoclonal antibody that enhances proliferation of monocytes by reverse signaling of 4 1BBL . 4 1BB Ligand ( 4 1BBL ) , a transmembrane molecule , member of the tumor necrosis factor ligand superfamily , is an important costimulatory molecule in the immune response . ^^^ This functional anti human 4 1BBL MAb provides a valuable tool for further study of biological functions as well as signal transduction of 4 1BBL / 4 1BB . . ^^^ |
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| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| Co stimulation via 4 1BB and its ligand 4 1BB ligand ( 4 1BB L ) plays an important role in cytotoxic and pro inflammatory immune responses . 4 1BB L is generally described on activated antigen presenting cells but there is limited information on its expression and function in human dendritic cells ( DC ) . ^^^ These DC expressed 4 1BB L mRNA transcripts with highest cell surface levels on HPC derived DC cultured with IL 1 . ^^^ Pro inflammatory activation , particularly CD 40 ligand+IL 1 , up regulated 4 1BB L on DC . ^^^ We confirmed reverse signaling via 4 1BB L as immobilized 4 1BB in conjunction with CD 40 L , enhanced IL 12beta mRNA and the secretion of IL 12 p 70 in various APC , including monocytes . ^^^ Altogether , DC may differ in T cell co stimulation properties due to variable and regulated levels of 4 1BB L . ^^^ |
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| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| Among these costimulatory molecules , strong expression of 4 1BBL and Fas was induced in the aortic tissue , and most of the infiltrating cells expressed 4 1BB and FasL , suggesting these pathways play critical roles in T cell mediated vascular injury . ^^^ Our findings strongly suggest that 4 1BB / 4 1BBL and Fas / FasL pathways play important roles in vascular injury in Takayasu ' s arteritis . ^^^ |
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| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| Functional expression of 4 1BB ( CD 137 ) in the inflammatory tissue in Crohn ' s disease . 4 1BB ligand ( L ) expressed on antigen presenting cells ( APC ) interacts with 4 1BB , expressed on activated T cells and this interaction costimulates T cells to secrete cytokines and to proliferate . ^^^ |
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| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| Longer transplant survival was induced by blockade of 4 1BB / 4 1BB ligand ( 4 1BBL ) interactions using an anti 4 1BBL monoclonal antibody . ^^^ Histological analysis showed that prolonged transplant survival in the 4 1BB deficient and anti 4 1BBL treated mice correlated with reduced lymphocytic infiltration and vasculitis in the donor heart tissue . ^^^ Taken together , our data suggest that blockade of 4 1BB / 4 1BBL interactions inhibited the expansion of alloreactive T cells and reduced CTL activity against host alloantigen , which in turn resulted in the prolongation of allograft survival . ^^^ Blockade of 4 1BB ( CD 137 ) / 4 1BB ligand interactions increases allograft survival . ^^^ |
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| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| Here we show that resting tonsillar MCs , when compared with lung MCs , revealed significantly higher expression levels for CC chemokines ( CCL 3 and 4 ) , which recruit T cells , and for TNFR superfamilies ( OX 40 ligand and 4 1BB ligand ) , which induce proliferation of T cells . ^^^ |
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| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| Immunity to melanoma mediated by 4 1BB is associated with enhanced activity of tumour infiltrating lymphocytes . 4 1BB costimulates T cells to carry out effector functions such as eradication of established tumours . 4 1BB ( CD 137 ) is a member of the TNF receptor family , and its triggering by either 4 1BB ligand or antibody ligation induces T cell activation and growth . ^^^ |
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| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| Surprisingly , wild type CD8+ memory T cells expanded normally in primed OX 40 ligand or 4 1BB ligand deficient mice . ^^^ However , when wild type memory cells were generated in OX 40 ligand or 4 1BB ligand deficient mice , their secondary expansion was impaired . ^^^ This provides the novel concept that stimulation of CD8+ T cells by OX 40 and 4 1BB ligand during priming imprints into them the capacity for secondary expansion . ^^^ |
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| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| In addition , incubation of activated CD8+ T cells with p 815 cells expressing 4 1BBL led to redistribution of the lipid raft domains and Lck , protein kinase C theta ; , SLP 76 , and phospholipase C gamma 1 ( PLC gamma 1 ) on the T cell membranes to the areas of contact with the p 815 cells and recruitment of 4 1BB , TNFR associated factor 2 , and phospho tyrosine proteins to the raft domains . 4 1BB ligation also caused translocation of TNFR associated factor 2 , protein kinase C theta ; , PLC gamma 1 , and SLP 76 to detergent insoluble compartments in the CD8+ T cells , and cross linking of 4 1BB increased intracellular Ca2+ levels apparently by activating PLC gamma 1 . ^^^ |
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| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| An abundance of NK cells for transduction was secured by culturing peripheral blood mononuclear cells with K 562 cells expressing the NK stimulatory molecules 4 1BB ligand and interleukin 15 , which yielded a median greater than 1000 fold expansion of CD56+CD3 cells at 3 weeks of culture , without T lymphocyte expansion . ^^^ |
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| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| In this study we highlight the involvement of 4 1BB / 4 1BBL in the development of T cell responses . ^^^ |
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| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| With potential clinical applications in mind , we further compare whether the natural 4 1BB ligand fused to mouse IgG2a ( Ig 4 1BBL ) would be as effective as the agonistic anti 4 1BB antibody . ^^^ In addition , the Ig 4 1BBL is as potent as the agonistic anti 4 1BB antibody for the treatment of hepatic MCA 26 colon carcinoma , resulting in 50 % complete tumor regression and long term survival . ^^^ Ig 4 1BBL had equivalent biological functions when compared to the agonistic anti 4 1BB antibody . ^^^ The systemic administration of Ig 4 1BB ligand in combination with IL 12 gene transfer eradicates hepatic colon carcinoma . ^^^ We have previously shown that the local membrane bound 4 1BB ligand and IL 12 gene transfer induced a significant antitumor response in a mouse colon carcinoma model . ^^^ |
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| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| Functional analyses demonstrate that purified T cells from NOD congenic mice with the C57BL / 10 ( B 10 ) allele at Idd9 . 3 produce more IL 2 and proliferate more vigorously in response to anti CD 3 plus immobilized 4 1BB ligand than T cells from NOD mice with the NOD allele at Idd9 . 3 . ^^^ |
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| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| Analysis of 4 1BB ligand ( 4 1BBL ) deficient cells supported this notion . ^^^ |
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| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| This resulted in a much higher affinity for 4 1BB ( 1 . 2 nM ) as compared with FLAG 4 1BBL ( 55 . 2 nM ) . ^^^ The mutation of this cysteine residue exerted no effect on trimerization but increased the dissociation rate of AviTag 4 1BBL from 4 1BB . ^^^ The interaction between 4 1BB ligand ( CD137L ) , a member of the tumor necrosis factor superfamily , and its receptor 4 1BB provides a co stimulatory signal for T lymphocyte proliferation and survival . ^^^ |
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| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| Several recently identified costimulators , namely , 4 1BB ligand , ICOS ligand , and OX 40 ligand , are up regulated on cultured HDMEC in response to TNF or coculture with allogeneic T cells . ^^^ Furthermore , blocking 4 1BB ligand , ICOS ligand , or OX 40 ligand in this model reduces human skin allograft injury and T cell effector molecule expression . ^^^ |
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| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| Involvement of 4 1BB ( CD 137 ) 4 1BBligand interaction in the modulation of CD 4 T cell mediated inflammatory colitis . 4 1BB ligand ( 4 1BBL ) expressed on antigen presenting cells interacts with 4 1BB on activated T cells ( especially CD8+ cells ) and co stimulates the latter to secrete cytokines and to proliferate . ^^^ The role of 4 1BB 4 1BBL interaction was studied here in a model of colitis based on naive CD4+ T cell transfer to SCID mice , a disease model in which CD 8 cells do not take part . ^^^ In conclusion , our data provide evidence that 4 1BB 4 1BBL interaction modulates the effector CD4+ T cell driven immune response and cytokine production in experimental colitis without affecting regulatory T cell function . . ^^^ |
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| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| The interaction of 4 1BB and 4 1BB ligand ( 4 1BBL ) activates an important costimulatory pathway with diverse and important roles in immune regulation . ^^^ In addition , blockade of 4 1BB / 4 1BBL interaction has produced therapeutic effects against coxsackievirus induced myocardial inflammation , herpetic stromal keratitis , and graft rejection . ^^^ |
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| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| The involvement of costimulatory markers OX40 / 4 1BB / 4 1BBL leads to the enhancement of signals which are necessary for lymphocyte activation in addition to the antigen specific signal and may prevent anergy . ^^^ |
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| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| We tested whether any intracellular signals are transmitted through 4 1BB / CD137 ligand ( 4 1BBL ) , using a 4 1BB Fc fusion protein and 4 1BB deficient mice . ^^^ Cross linking 4 1BBL with immobilized 4 1BB Fc also dramatically reduced the number of tartrate resistant acid phosphatase ( TRAP ) positive multinuclear cells ( MNC ) derived from the BMM from 4 1BB deficient mice , suggesting that the inhibitory effect of immobilized 4 1BB on osteoclastogenesis is due to a signal through 4 1BBL . ^^^ A signal through 4 1BB ligand inhibits receptor for activation of nuclear factor kappaB ligand ( RANKL ) induced osteoclastogenesis by increasing interferon ( IFN ) beta production . ^^^ |
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| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| Thus , it appears that 4 1BB / 4 1BBL interactions control the number of surviving CD8+ effector memory cells , late in the primary response . ^^^ These data suggest a model whereby 4 1BB expression on memory CD8+ T cells , perhaps due to encounter with IL 15 in the bone marrow , allows 4 1BB / 4 1BBL interactions to maintain memory CD 8 T cell survival in the absence of Ag . . ^^^ |
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| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| Crystallization and preliminary 10 ray crystallographic study of the extracellular domain of the 4 1BB ligand , a member of the TNF family . ^^^ The 4 1BB ligand , a member of the tumour necrosis factor ( TNF ) family , is an important co stimulatory molecule that plays a key role in the clonal expansion and survival of CD8+ T cells . ^^^ Signalling through binding of the 4 1BB ligand and 4 1BB has been reported to enhance CD8+ T cell expansion and protect activated CD8+ T cells from death . ^^^ The 4 1BB ligand is an integral protein expressed on activated antigen presenting cells . ^^^ The extracellular domain of the 4 1BB ligand fused with glutathione S transferase was expressed in Escherichia coli ( Origami ) and purified by using affinity and ion exchange column chromatographic methods . ^^^ |
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| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| This study was conducted to determine if a poxvirus expressing the ligand for 4 1BB ( 4 1BBL ) could further improve the immune and therapeutic responses of a previously reported poxvirus vaccine expressing a triad of costimulatory molecules ( B7 . 1 , ICAM 1 , and LFA 3 ) . ^^^ |
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| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| Gene therapy using adenoviral vector encoding 4 1BBIg gene significantly prolonged murine cardiac allograft survival . 4 1BB , a member of the tumor necrosis factor ( TNF ) receptor superfamily , interacts with 4 1BBL expressed on APC and delivers a costimulatory signal for T cell activation and growth . ^^^ |
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| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| However , inhibition of 4 1BB / 4 1BB ligand ( 4 1BBL ) interaction does not suppress the development of EAU . ^^^ It appears that cross linking of 4 1BB evokes an active antigen specific suppression mechanism rather than merely blocking 4 1BB / 4 1BBL interaction . ^^^ |
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| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| The expanded CD8+ population contained more cells expressing CD 137 ( 4 1BB ) , CD 137 ( 4 1BBL ) , CD 30 ( Ki 1 ) , CD 40 and CD 134 ( OX 40 ) . ^^^ |
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| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| This unique function of OX40L was not shared by two costimulatory TNF family members , GITR ligand and 4 1BB ligand . ^^^ |
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| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| Increased soluble 4 1BB ligand ( 4 1BBL ) levels in peripheral blood of patients with multiple sclerosis . 4 1BB ligand ( 4 1BBL ; CD137L ) is a member of the tumour necrosis factor superfamily expressed primarily on antigen presenting cells such as B cells , macrophages and dendritic cells . ^^^ The elevated s 4 1BBL protein levels in the MS patients may function as a self regulatory mechanism of 4 1BB / 4 1BBL interaction and costimulation . . ^^^ |
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| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| Polyclonal CD4+ T lymphocytes can be activated and expanded using anti CD 3 and anti CD 28 antibodies presented on magnetic beads , and CD8+T lymphocytes can be successfully expanded using a novel genetically engineered cell based technology that presents anti CD 3 and anti CD 28 along with the costimulatory molecule CD 137 ( 4 1BBL ) . ^^^ |
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| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| A panel of monoclonal antibodies specific for CD 27 ligand ( CD 70 ) , CD 30 ligand ( CD 153 ) , CD 134 ligand ( OX40L ) , and CD 137 ligand ( 4 1BBL ) were screened in vivo for their ability to affect the control of Mycobacterium avium infection in C57Bl / 6 mice . ^^^ |
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| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q07011 and P41273 |
Pubmed |
SVM Score :0.0 |
| NA |
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