| Interacting proteins: Q06787 and P51116 |
Pubmed |
SVM Score :0.0 |
| Recently , two proteins homologous to FMRP were discovered : FXR 1 and FXR 2 . ^^^ |
|
| Interacting proteins: Q06787 and P51116 |
Pubmed |
SVM Score :0.0 |
| FXR 2 protein , which is closely related to FMRP , is also detected associated with mRNPs in translating polyribosomes . ^^^ |
|
| Interacting proteins: Q06787 and P51116 |
Pubmed |
SVM Score :0.0 |
| Two autosomal homologues of the FMR 1 gene , FXR 1 and FXR 2 , have been identified and the overall structures of the corresponding proteins are very similar to that of FMRP . ^^^ |
|
| Interacting proteins: Q06787 and P51116 |
Pubmed |
SVM Score :0.0 |
| We analyzed the distribution of FMR 1 , FXR 1 , FXR 2 mRNA , and FMRP in whole normal human embryos and in the brains of normal and fragile 10 fetuses . ^^^ The coexpression in the same tissues of FMR 1 , FXR 1 , and FXR 2 , associated with the normal expression of FXR 1 and FXR 2 and the absence of obvious neuropathological abnormalities in pathological brains , supports the notion that the FXR 1 and FXR 2 proteins partially compensate for FMRP function . ^^^ Thus , a dominant negative effect of abnormal multimeric protein complexes lacking FMRP ( e . g . by modification of FXR 1 and FXR 2 protein functions ) may result in the fragile 10 syndrome phenotype . . ^^^ |
|
| Interacting proteins: Q06787 and P51116 |
Pubmed |
SVM Score :0.0 |
| NUFIP does not interact with the FMRP homologues encoded by the FXR 1 and FXR 2 genes . ^^^ |
|
| Interacting proteins: Q06787 and P51116 |
Pubmed |
SVM Score :0.0 |
| This effect is specific for FMRP , since other proteins with similar RNA binding domains , including the autosomal homologues of FMRP , FXR 1 and FXR 2 , failed to suppress translation in the same concentration range . ^^^ The failure of FMRP I304N to suppress translation is not due to its reduced affinity for mRNA or its interacting proteins FXR 1 and FXR 2 . ^^^ |
|
| Interacting proteins: Q06787 and P51116 |
Pubmed |
SVM Score :0.0 |
| In earlier studies , we found that Fmr 1 knockout ( KO ) mice , which do not express Fmrp , and Fxr 2 KO mice , which do not express Fxr2p , show similarities in some behavioral responses such as hyperactivity . ^^^ To better understand the functional relationship between FMRP and FXR2P , we generated Fmr 1 KO , Fxr 2 KO , Fmr1 / Fxr2 double KO and wild type control mice as littermates on the same genetic background and examined them in several behavioral assays . ^^^ |
|
| Interacting proteins: Q06787 and P51116 |
Pubmed |
SVM Score :0.0 |
| This novel protein , FXR 2 , is very similar to FMR 1 ( 60 % identity ) . ^^^ FXR 2 encodes a 74 kDa protein which , like FMR 1 , contains two KH domains , has the capacity to bind RNA and is localized to the cytoplasm . ^^^ In addition , FMR 1 and FXR 2 interact tightly with the recently described autosomal homolog FXR 1 . ^^^ FXR 1 and FXR 2 are thus likely to play important roles in the function of FMR 1 and in the pathogenesis of the Fragile 10 Mental Retardation Syndrome . . ^^^ |
|
| Interacting proteins: Q06787 and P51116 |
Pubmed |
SVM Score :0.0 |
| Recently , we described two novel cytoplasmic proteins , FXR 1 and FXR 2 , which are both very similar in amino acid sequence to FMR 1 and which also interact strongly with FMR 1 and with each other . ^^^ The association of the FMR 1 , FXR 1 , and FXR 2 proteins with ribosomes suggests they have functions in translation or mRNA stability . . ^^^ |
|
| Interacting proteins: Q06787 and P51116 |
Pubmed |
SVM Score :0.0 |
| Ordering of 66 STSs along the entire short arm of human chromosome 17 and chromosome assignment of a transcribed sequence ( FMR1L2 ) homologous to FMR 1 . ^^^ FMR1L2 , a second FMR 1 autosomal homologue has been identified and assigned to a genomic interval between D17S796 and D17S799 . . ^^^ |
|
| Interacting proteins: Q06787 and P51116 |
Pubmed |
SVM Score :0.0 |
| While the cDNA has two regions with similarity to the mouse double KH domain probe at the nucleotide level , there is no significant similarity of the amino acid sequence with human FMR 1 , FXR 1 or FXR 2 , nor with KH amino acid motifs . ^^^ |
|
| Interacting proteins: Q06787 and P51116 |
Pubmed |
SVM Score :0.0 |
| Both FXR 1 and FXR 2 are autosomal gene homologues of FMR 1 . ^^^ |
|
| Interacting proteins: Q06787 and P51116 |
Pubmed |
SVM Score :0.0 |
| FMR 1 encodes a cytoplasmic RNA binding protein which interacts with two autosomal homologs , FXR 1 and FXR 2 . ^^^ |
|
| Interacting proteins: Q06787 and P51116 |
Pubmed |
SVM Score :0.0 |
| In mammals , FMR 1 is a member of a small protein family that consists of FMR 1 , FXR 1 , and FXR 2 . ^^^ |
|
| Interacting proteins: Q06787 and P51116 |
Pubmed |
SVM Score :0.0 |
| Comparative genomic sequence analysis of the FXR gene family : FMR 1 , FXR 1 , and FXR 2 . ^^^ Two autosomal paralogs of FMR 1 have been identified , and are known as FXR 1 and FXR 2 . ^^^ Here we describe and compare the genomic structures of the mouse and human genes FMR 1 , FXR 1 , and FXR 2 . ^^^ |
|
| Interacting proteins: Q06787 and P51116 |
Pubmed |
SVM Score :0.0 |
| Given the behavioral phenotype in fragile 10 patients and the phenotype previously reported for the Fmr 1 knockout mouse , we performed a thorough evaluation of the Fxr 2 knockout phenotype using a behavioral test battery . ^^^ Interestingly , there are some behavioral phenotypes in Fxr 2 knockout mice which are similar to those observed in Fmr 1 knockout mice , but there are also some different behavioral abnormalities that are only observed in the Fxr 2 mutant mice . ^^^ |
|
| Interacting proteins: Q06787 and P51116 |
Pubmed |
SVM Score :0.0 |
| Mouse knockout ( KO ) models exist for both Fmr 1 and Fxr 2 . ^^^ |
|
| Interacting proteins: Q06787 and P51116 |
Pubmed |
SVM Score :0.0 |
| The 10 linked FMR 1 gene , which is involved in the fragile 10 syndrome , forms a small gene family with its two autosomal homologs , FXR 1 and FXR 2 . ^^^ |
|
| Interacting proteins: Q06787 and P51116 |
Pubmed |
SVM Score :0.0 |
| FXR 1 and FXR 2 are autosomal paralogs of FMR 1 . ^^^ We demonstrate that zebrafish possess only three FMR 1 related genes , fmr 1 , fxr 1 and fxr 2 , and these are orthologous to the human FMR 1 , FXR 1 and FXR 2 genes respectively . ^^^ Expression of fmr 1 , fxr 1 and fxr 2 is widespread throughout this time . ^^^ |
|
| Interacting proteins: Q06787 and P51116 |
Pubmed |
SVM Score :0.0 |
| The Fxr gene family is composed of three members , FMR 1 , FXR 1 and FXR 2 . ^^^ In Xenopus tropicalis both Fmr 1 and Fxr 1 were identified ; however , unexpectedly Fxr 2 was not . ^^^ |
|
| Interacting proteins: Q06787 and P51116 |
Pubmed |
SVM Score :0.0 |
| NA |
|