| Interacting proteins: P51114 and Q06787 |
Pubmed |
SVM Score :0.57397118 |
| In addition , FMR 1 and FXR 2 interact tightly with the recently described autosomal homolog FXR 1 . 0.57397118^^^ |
|
| Interacting proteins: P51114 and Q06787 |
Pubmed |
SVM Score :0.0 |
| We found a novel gene , FXR 1 , that is highly homologous to FMR 1 and located on chromosome 12 at 12q13 . ^^^ FXR 1 encodes a protein which , like FMR 1 , contains two KH domains and is highly conserved in vertebrates . ^^^ The KH domains of FXR 1 and FMR 1 are almost identical , and the two proteins have similar RNA binding properties in vitro . ^^^ However , FXR 1 and FMR 1 have very different carboxy termini . ^^^ FXR 1 and FMR 1 are expressed in many tissues , and both proteins , which are cytoplasmic , can be expressed in the same cells . ^^^ |
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| Interacting proteins: P51114 and Q06787 |
Pubmed |
SVM Score :0.0 |
| Highly conserved 3 ' UTR and expression pattern of FXR 1 points to a divergent gene regulation of FXR 1 and FMR 1 . ^^^ A search for genes with sequence homologies to the FMR 1 gene resulted in the isolation of mouse and human homologues of the recently described FXR 1 gene . ^^^ The mouse FXR 1 gene shares amino acid identity and similarity of 99 . 1 % and 99 . 6 % , respectively , with the human FXR 1 gene and amino acid identify and similarity of 67 . 3 % and 79 . 5 % respectively , with the mouse FMR 1 gene . ^^^ The gene structure of FXR 1 is very similar to that of FMR 1 and both genes probably originate from a common ancestral gene . ^^^ While FMR 1 is highly expressed in proliferating spermatogonia , FXR 1 is highly expressed in postmeiotic spermatids . . ^^^ |
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| Interacting proteins: P51114 and Q06787 |
Pubmed |
SVM Score :0.0 |
| Recently , we described two novel cytoplasmic proteins , FXR 1 and FXR 2 , which are both very similar in amino acid sequence to FMR 1 and which also interact strongly with FMR 1 and with each other . ^^^ The association of the FMR 1 , FXR 1 , and FXR 2 proteins with ribosomes suggests they have functions in translation or mRNA stability . . ^^^ |
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| Interacting proteins: P51114 and Q06787 |
Pubmed |
SVM Score :0.0 |
| Differential expression of FMR 1 , FXR 1 and FXR 2 proteins in human brain and testis . ^^^ In adult brain , FMR 1 , FXR 1 and FXR 2 proteins are coexpressed in the cytoplasm of specific differentiated neurons only . ^^^ Recently , two proteins homologous to FMRP were discovered : FXR 1 and FXR 2 . ^^^ |
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| Interacting proteins: P51114 and Q06787 |
Pubmed |
SVM Score :0.0 |
| Two autosomal homologues of the FMR 1 gene , FXR 1 and FXR 2 , have been identified and the overall structures of the corresponding proteins are very similar to that of FMRP . ^^^ The complex expression pattern of FXR1P suggests tissue specific expression for the various isoforms of FXR 1 and the differential expression of FMRP and FXR1Ps suggests that in certain types of cells and tissues , complementary functions may be fulfilled by the various FMRP family members . . ^^^ |
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| Interacting proteins: P51114 and Q06787 |
Pubmed |
SVM Score :0.0 |
| While the cDNA has two regions with similarity to the mouse double KH domain probe at the nucleotide level , there is no significant similarity of the amino acid sequence with human FMR 1 , FXR 1 or FXR 2 , nor with KH amino acid motifs . ^^^ |
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| Interacting proteins: P51114 and Q06787 |
Pubmed |
SVM Score :0.0 |
| Reported cDNAs for human , murine , and Xenopus FXR 1 suggested the potential for alternatively spliced isoforms , a feature also found in the FMR 1 gene . ^^^ |
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| Interacting proteins: P51114 and Q06787 |
Pubmed |
SVM Score :0.0 |
| Expression of FMR 1 , FXR 1 , and FXR 2 genes in human prenatal tissues . ^^^ We analyzed the distribution of FMR 1 , FXR 1 , FXR 2 mRNA , and FMRP in whole normal human embryos and in the brains of normal and fragile 10 fetuses . ^^^ The coexpression in the same tissues of FMR 1 , FXR 1 , and FXR 2 , associated with the normal expression of FXR 1 and FXR 2 and the absence of obvious neuropathological abnormalities in pathological brains , supports the notion that the FXR 1 and FXR 2 proteins partially compensate for FMRP function . ^^^ However , the absence of significant overexpression of FXR 1 and FXR 2 in pathological brains suggests that these genes do not compensate for the lack of FMR 1 expression . ^^^ Alternatively , FMR 1 , FXR 1 , and FXR 2 proteins may not have compensatory functions , but instead may regulate functions by hetero or homo oligomerization , as suggested by other studies . ^^^ |
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| Interacting proteins: P51114 and Q06787 |
Pubmed |
SVM Score :0.0 |
| NUFIP does not interact with the FMRP homologues encoded by the FXR 1 and FXR 2 genes . ^^^ |
|
| Interacting proteins: P51114 and Q06787 |
Pubmed |
SVM Score :0.0 |
| Both FXR 1 and FXR 2 are autosomal gene homologues of FMR 1 . ^^^ |
|
| Interacting proteins: P51114 and Q06787 |
Pubmed |
SVM Score :0.0 |
| FMR 1 encodes a cytoplasmic RNA binding protein which interacts with two autosomal homologs , FXR 1 and FXR 2 . ^^^ |
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| Interacting proteins: P51114 and Q06787 |
Pubmed |
SVM Score :0.0 |
| In mammals , FMR 1 is a member of a small protein family that consists of FMR 1 , FXR 1 , and FXR 2 . ^^^ |
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| Interacting proteins: P51114 and Q06787 |
Pubmed |
SVM Score :0.0 |
| This effect is specific for FMRP , since other proteins with similar RNA binding domains , including the autosomal homologues of FMRP , FXR 1 and FXR 2 , failed to suppress translation in the same concentration range . ^^^ The failure of FMRP I304N to suppress translation is not due to its reduced affinity for mRNA or its interacting proteins FXR 1 and FXR 2 . ^^^ |
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| Interacting proteins: P51114 and Q06787 |
Pubmed |
SVM Score :0.0 |
| Comparative genomic sequence analysis of the FXR gene family : FMR 1 , FXR 1 , and FXR 2 . ^^^ Two autosomal paralogs of FMR 1 have been identified , and are known as FXR 1 and FXR 2 . ^^^ Here we describe and compare the genomic structures of the mouse and human genes FMR 1 , FXR 1 , and FXR 2 . ^^^ Finally , we noted several regions of mouse / human homology in the noncoding portions of FMR 1 and FXR 1 . ^^^ |
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| Interacting proteins: P51114 and Q06787 |
Pubmed |
SVM Score :0.0 |
| FXR 1 is one of the two known homologues of FMR 1 . ^^^ FXR 1 shares a high degree of sequence homology with FMR 1 and also encodes two KH domains and an RGG domain , conferring RNA binding capabilities . ^^^ |
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| Interacting proteins: P51114 and Q06787 |
Pubmed |
SVM Score :0.0 |
| The 10 linked FMR 1 gene , which is involved in the fragile 10 syndrome , forms a small gene family with its two autosomal homologs , FXR 1 and FXR 2 . ^^^ |
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| Interacting proteins: P51114 and Q06787 |
Pubmed |
SVM Score :0.0 |
| FXR 1 and FXR 2 are autosomal paralogs of FMR 1 . ^^^ We demonstrate that zebrafish possess only three FMR 1 related genes , fmr 1 , fxr 1 and fxr 2 , and these are orthologous to the human FMR 1 , FXR 1 and FXR 2 genes respectively . ^^^ Expression of fmr 1 , fxr 1 and fxr 2 is widespread throughout this time . ^^^ |
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| Interacting proteins: P51114 and Q06787 |
Pubmed |
SVM Score :0.0 |
| Two members of the Fxr gene family , Fmr 1 and Fxr 1 , are differentially expressed in Xenopus tropicalis . ^^^ The Fxr gene family is composed of three members , FMR 1 , FXR 1 and FXR 2 . ^^^ In Xenopus tropicalis both Fmr 1 and Fxr 1 were identified ; however , unexpectedly Fxr 2 was not . ^^^ |
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| Interacting proteins: P51114 and Q06787 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51114 and Q06787 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51114 and Q06787 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51114 and Q06787 |
Pubmed |
SVM Score :0.0 |
| NA |
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