| Interacting proteins: Q9BXW9 and Q06609 |
Pubmed |
SVM Score :0.0 |
| Since all FA cells , except FA D 1 , lack the monoubiquitinated FANCD 2 L protein , this isoform is likely to be involved in the formation of nuclear foci containing RAD 51 in diploid FA cells . ^^^ FA D 1 cells show the same attenuation in RAD 51 foci formation , suggesting that the unknown FANCD 1 protein is similarly involved in RAD 51 foci formation , either independently or as a subsequent step in the FANCD 2 pathway . ^^^ |
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| Interacting proteins: Q9BXW9 and Q06609 |
Pubmed |
SVM Score :0.0 |
| S phase specific interaction of the Fanconi anemia protein , FANCD 2 , with BRCA 1 and RAD 51 . ^^^ Monoubiquitinated FANCD 2 colocalizes with BRCA 1 and RAD 51 in S phase specific nuclear foci . ^^^ |
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| Interacting proteins: Q9BXW9 and Q06609 |
Pubmed |
SVM Score :0.0 |
| However , the localization of Rad 51 , Brca 1 , Fancd 2 and Mlh 1 appeared normal on Fanca ( tm1Hsc ) homozygous meiotic chromosomes . ^^^ |
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| Interacting proteins: Q9BXW9 and Q06609 |
Pubmed |
SVM Score :0.0 |
| Here , we describe the recent progress in our understanding of how Rad 51 is involved in the signalling and repair of DNA damage and how tumour suppressors , such as p 53 , ATM , BRCA 1 , BRCA 2 , BLM and FANCD 2 are linked to Rad 51 dependent pathways . ^^^ |
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| Interacting proteins: Q9BXW9 and Q06609 |
Pubmed |
SVM Score :0.0 |
| FANCD 2 did not interact with RAD 51 , the five RAD 51 paralogs , RAD 52 , RAD 54 or DMC 1 . ^^^ FANCD 2 colocalized with RAD 51 in foci following treatment with mitomycin C or hydroxyurea , and colocalized very tightly with PCNA after treatment with hydroxyurea . ^^^ |
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| Interacting proteins: Q9BXW9 and Q06609 |
Pubmed |
SVM Score :0.0 |
| In response to DNA damaging agents , and during S phase of the cell cycle , the FA pathway is activated via the mono ubiquitination of FANCD 2 ( FANCD 2 Ub ) , signaling its translocation to discrete nuclear foci , where it co localizes with the central DNA repair proteins BRCA 1 and RAD 51 . ^^^ |
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| Interacting proteins: Q9BXW9 and Q06609 |
Pubmed |
SVM Score :0.0 |
| Fanconi anemia complementation group D 2 ( FANCD 2 ) functions independently of BRCA 2 and RAD 51 associated homologous recombination in response to DNA damage . ^^^ We show that in response to DNA damage , BRCA 2 dependent Rad 51 nuclear focus formation was normal in the absence of FANCD 2 and that FANCD 2 nuclear focus formation and mono ubiquitination appeared normal in BRCA 2 deficient cells . ^^^ Furthermore , we established that depletion of BRCA 2 or Rad 51 had a greater effect on cell survival in response to MMC than depletion of FANCD 2 and that depletion of BRCA 2 in FANCD 2 mutant cells further sensitized these cells to MMC . ^^^ Our results suggest that FANCD 2 mediates double strand DNA break repair independently of Rad 51 associated homologous recombination . . ^^^ |
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| Interacting proteins: Q9BXW9 and Q06609 |
Pubmed |
SVM Score :0.0 |
| Our results suggest that exon 27 of murine Brca 2 is crucial for the interaction of Brca 2 and Fancd 2 in Rad 51 mediated recombination in response to DNA damage , but that this interaction is not taking place in the homologous recombination during meiosis . . ^^^ |
|
| Interacting proteins: Q9BXW9 and Q06609 |
Pubmed |
SVM Score :0.0 |
| Since cells from the FA D 1 and FA J patient groups are both able to monoubiquitinate FANCD 2 , the `` Rad 51 foci phenotype ' ' provides a convenient assay to distinguish between these two groups . ^^^ |
|
| Interacting proteins: Q9BXW9 and Q06609 |
Pubmed |
SVM Score :0.0 |
| In contrast , repair factors ( Rad 51 , Rad 52 , BRCA 2 , and FANCD 2 ) , ATM and Rad 3 related ( ATR ) cascade ( ATR , ATR interacting protein , and replication protein A ) , and the DNA clamp ( Rad 17 and 9 ) accumulate in subchromatin microcompartments delineated by single stranded DNA ( ssDNA ) . ^^^ |
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| Interacting proteins: Q9BXW9 and Q06609 |
Pubmed |
SVM Score :0.0 |
| The BRCA2 / FANCD1 protein is connected to the FA pathway by interactions with the FANCG and FANCD 2 proteins , both of which co localise with the RAD 51 recombinase , which is regulated by BRCA 2 . ^^^ |
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| Interacting proteins: Q9BXW9 and Q06609 |
Pubmed |
SVM Score :0.0 |
| Here we show that BRCA 2 dependent chromatin loading of Rad 51 after mitomycin C treatment was not compromised by disruption of FANCC or FANCD 2 . ^^^ Rad 51 and FancD 2 form colocalizing subnuclear foci independently of each other . ^^^ |
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| Interacting proteins: Q9BXW9 and Q06609 |
Pubmed |
SVM Score :0.0 |
| Monoubiquitinated FANCD 2 translocates to damage induced nuclear foci containing BRCA 1 , BRCA 2 , and Rad 51 , thereby protecting the genome . ^^^ |
|
| Interacting proteins: Q9BXW9 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9BXW9 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9BXW9 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9BXW9 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9BXW9 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9BXW9 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9BXW9 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9BXW9 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9BXW9 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9BXW9 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9BXW9 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9BXW9 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9BXW9 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
|