| Interacting proteins: Q13315 and Q06609 |
Pubmed |
SVM Score :0.0 |
| Using Western blots we measured , in non irradiated cells , the basal expression levels of ATM , Rad 1 and Hus 1 , involved in the control of cellular DNA damage checkpoints , together with DNA PKcs , Ku 70 , Ku 80 ; XRCC 4 , ligaseIV and Rad 51 , involved in radiation induced DSB repair . ^^^ |
|
| Interacting proteins: Q13315 and Q06609 |
Pubmed |
SVM Score :0.0 |
| BRCA 1 contains several functional domains that interact directly or indirectly with a variety of molecules , including tumor suppressors ( p 53 , RB , BRCA 2 and ATM ) , oncogenes ( c Myc , casein kinase 2 and E2F ) , DNA damage repair proteins ( RAD 50 and RAD 51 ) , cell cycle regulators ( cyclins and cyclin dependent kinases ) , transcriptional activators and repressors ( RNA polymerase 2 , RHA , histone deacetylase complex and CtIP ) and others . ^^^ |
|
| Interacting proteins: Q13315 and Q06609 |
Pubmed |
SVM Score :0.0 |
| Abl tyrosine kinase is not essential for ataxia telangiectasia mutated functions in chromosomal maintenance . c Abl is activated by DNA damage in an ataxia telangiectasia mutated ( ATM ) dependent manner and plays important roles in growth arrest and apoptosis induced by DNA damage . c Abl also interacts physically and functionally with Rad 51 , a key molecule in homologous recombinational ( HR ) DNA repair . ^^^ |
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| Interacting proteins: Q13315 and Q06609 |
Pubmed |
SVM Score :0.0 |
| We have located the single nucleotide changes suffered in recA sequence of 2 recF partial suppressor mutations : srf 2020 at codon 121 and srf 801 at codon 257 . srf 2020 changes codon 121 from threonine ( ACC ) to isoleucine ( ATC ) . srf 801 changes codon 257 from glutamine ( CAG ) to proline ( CCG ) . ^^^ |
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| Interacting proteins: Q13315 and Q06609 |
Pubmed |
SVM Score :0.0 |
| Atm is required for proper assembly of Rad 51 onto the chromosomal axial elements during meiosis . ^^^ Because Atm deficient mice are viable but completely infertile , our studies suggest that the Rad 51 assembly defects and elevated levels of p 53 , p 21 and Bax represent tissue specific responses to the absence of Atm . . ^^^ |
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| Interacting proteins: Q13315 and Q06609 |
Pubmed |
SVM Score :0.0 |
| ATR , a protein related to ATM , DMC 1 , a RAD 51 family member , and RAD 51 are mislocalized to chromatin and have reduced localization to developing synaptonemal complexes in spermatocytes from Atm deficient mice , suggesting dysregulation of the orderly progression of meiotic events . ^^^ |
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| Interacting proteins: Q13315 and Q06609 |
Pubmed |
SVM Score :0.0 |
| Radiation induced assembly of Rad 51 and Rad 52 recombination complex requires ATM and c Abl . ^^^ Here we demonstrate that there is an 1 R induced Rad 51 tyrosine phosphorylation , and this induction is dependent on both ATM and c Abl . ^^^ ATM , c Abl , and Rad 51 can be co immunoprecipitated from cell extracts . ^^^ After 1 R , an increase in association between Rad 51 and Rad 52 occurs in wild type cells but not in cells with mutations that compromise ATM or c Abl . ^^^ Our data suggest signaling mediated through ATM , and c Abl is required for the correct post translational modification of Rad 51 , which is critical for the assembly of Rad 51 repair protein complex following 1 R . . ^^^ |
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| Interacting proteins: Q13315 and Q06609 |
Pubmed |
SVM Score :0.0 |
| ATM ( / ) cells show altered kinetics of radiation induced Rad 51 and Rad 54 focus formation . ^^^ |
|
| Interacting proteins: Q13315 and Q06609 |
Pubmed |
SVM Score :0.0 |
| Thus , RAD 51 , XRCC 2 and XRCC 3 act in the same pathway for centrosome fragmentation , independently of the sensitivity to exogenous genotoxic stresses and of the ATM / ATR pathway . . ^^^ |
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| Interacting proteins: Q13315 and Q06609 |
Pubmed |
SVM Score :0.0 |
| CONCLUSION : ATM belongs to a group of repair proteins , including PARP , DNA PK and HsRad 51 , which are specifically cleaved during apoptosis . ^^^ |
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| Interacting proteins: Q13315 and Q06609 |
Pubmed |
SVM Score :0.0 |
| No effect on survival was seen for polymorphisms in ATM , BRCA1 / 2 , CHK 2 , KU 70 , NBS 1 , RAD 51 , RAD 52 , XRCC 3 , AR , COMT , NQO 1 , VDR , ADH 3 , CYP1A1 , GSTP 1 , TGF beta , or CDH 1 . ^^^ |
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| Interacting proteins: Q13315 and Q06609 |
Pubmed |
SVM Score :0.0 |
| To facilitate association based linkage studies we have studied the linkage disequilibrium ( LD ) and haplotype architecture around five genes of interest for cancer risk : ATM , BRCA 1 , BRCA 2 , RAD 51 , and TP 53 . ^^^ |
|
| Interacting proteins: Q13315 and Q06609 |
Pubmed |
SVM Score :0.0 |
| Ionizing radiation induced Rad 51 nuclear focus formation is cell cycle regulated and defective in both ATM ( / ) and c Abl ( / ) cells . ^^^ In conclusion , effective and prompt IR induced Rad 51 focus formation is cell cycle regulated and requires both ATM and c Abl . . ^^^ |
|
| Interacting proteins: Q13315 and Q06609 |
Pubmed |
SVM Score :0.0 |
| We show the immediate response of PARPs to local irradiation , concomitant with the recruitment of ATM and Rad 51 at sites of DNA damage , both proteins being involved in DNA strand break repair . ^^^ |
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| Interacting proteins: Q13315 and Q06609 |
Pubmed |
SVM Score :0.0 |
| In summary , our results suggest that neocarzinostatin induces Rad 51 focus formation through an ATM and cell cycle dependent , but NBS 1 independent , pathway . . ^^^ |
|
| Interacting proteins: Q13315 and Q06609 |
Pubmed |
SVM Score :0.0 |
| Here , we describe the recent progress in our understanding of how Rad 51 is involved in the signalling and repair of DNA damage and how tumour suppressors , such as p 53 , ATM , BRCA 1 , BRCA 2 , BLM and FANCD 2 are linked to Rad 51 dependent pathways . ^^^ |
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| Interacting proteins: Q13315 and Q06609 |
Pubmed |
SVM Score :0.0 |
| An increase in protein expression of integrin alphav , integrin beta 1 , MAPK ( p 42 ) , Rad 51 , DNA PK ( CS ) , and ataxia telangiectasia gene ( ATM ) was detected in HUVEC grown in CC with GFP U 87 cells compared with HUVEC grown in mono culture . ^^^ |
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| Interacting proteins: Q13315 and Q06609 |
Pubmed |
SVM Score :0.0 |
| Gene targeting of ATM reduced , but did not abrogate , centrosome amplification induced by DNA damage in both the Rad 51 and Rad 54 knockout models , demonstrating ATM dependent and independent components of DNA damage inducible G 2 phase centrosome amplification . ^^^ |
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| Interacting proteins: Q13315 and Q06609 |
Pubmed |
SVM Score :0.0 |
| This band was also completely supershifted by the addition of antibodies to ATM , Ku 70 , DNA ligase 3 , Rpa 32 , Rpa 14 , DNA ligase 4 , XRCC 4 , WRN , BLM , RAD 51 and p 53 . ^^^ The density of one of the DNA EBCs predicted the radiosensitization caused by BRCA haploinsufficiency , and this band contains Ku 70 , ATM , DNA ligase 3 , Rpa 32 , Rpa 14 , DNA ligase 4 , XRCC 4 , WRN , BLM , RAD 51 and p 53 but not BRCA 1 or 2 . ^^^ |
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| Interacting proteins: Q13315 and Q06609 |
Pubmed |
SVM Score :0.0 |
| The proteins involved in FA act coordinately in the cellular response to DNA cross links in a pathway that has been shown to interact physically or functionally with a variety of other proteins involved in DNA repair or cell cycle control , notably BRCA 1 , Rad 51 , ATM , ATR , and Nbs 1 . ^^^ |
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| Interacting proteins: Q13315 and Q06609 |
Pubmed |
SVM Score :0.0 |
| MATERIALS AND METHODS : We have studied two tissue microarrays that include 103 familial and 104 sporadic breast tumors , with a panel of DNA repair markers including ATM , CHEK 2 , RAD 51 , RAD 50 , XRCC 3 , and proliferating cell nuclear antigen . ^^^ |
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| Interacting proteins: Q13315 and Q06609 |
Pubmed |
SVM Score :0.0 |
| In contrast , repair factors ( Rad 51 , Rad 52 , BRCA 2 , and FANCD 2 ) , ATM and Rad 3 related ( ATR ) cascade ( ATR , ATR interacting protein , and replication protein A ) , and the DNA clamp ( Rad 17 and 9 ) accumulate in subchromatin microcompartments delineated by single stranded DNA ( ssDNA ) . ^^^ |
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| Interacting proteins: Q13315 and Q06609 |
Pubmed |
SVM Score :0.0 |
| We analyzed 49 SNPs in BRCA 1 , BRCA 2 , ESR 1 , XRCC 1 , XRCC 2 , XRCC 3 , NBN , RAD 51 , RAD 52 , LIG 4 , ATM , BCL 2 , TGFB 1 , MSH 6 , ERCC 2 , XPF , NR3C1 , CYP1A1 , CYP2C9 , CYP2C19 , CYP3A5 , CYP2D6 , CYP11B2 , and CYP17A1 genes using the Pyrosequencing technique . ^^^ |
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| Interacting proteins: Q13315 and Q06609 |
Pubmed |
SVM Score :0.0 |
| FA proteins interact with various proteins involved in DNA damage response and cell cycle checkpoint regulation , such as : RAD 51 , BRCA 1 , BRCA 2 , ATM or NBS 1 . ^^^ |
|
| Interacting proteins: Q13315 and Q06609 |
Pubmed |
SVM Score :0.0 |
| Finally , we demonstrate the specificity of this phenotype by showing that the DNA repair and / or checkpoint mutants mgt 1 delta , mag 1 delta , apn 1 delta , rev 3 delta , rad 18 delta , rad 16 delta , dun 1 delta 100 , sad 4 1 , tel 1 delta , rad 26 delta , rad 51 delta , rad 52 1 , rad 54 delta , rad 14 delta , rad 1 delta , pol 30 46 , pol 30 52 , mad 3 delta , pds 1 delta / esp2 delta , pms 1 delta , mlh 1 delta , and msh 2 delta are all proficient at S phase regulation , even though some of these mutations confer sensitivity to alkylation . . ^^^ |
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| Interacting proteins: Q13315 and Q06609 |
Pubmed |
SVM Score :0.0 |
| Inactivation of Tel 1 or either the Rad 51 or Rad 59 recombination pathways in telomerase deficient cells increased the GCR rate , even though telomeres were maintained . ^^^ We observed chromosome fusions only in mutant strains expressing Rad 51 and Rad 55 or when Tel 1 was inactivated . ^^^ |
|
| Interacting proteins: Q13315 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13315 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13315 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13315 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13315 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13315 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13315 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13315 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13315 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13315 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13315 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13315 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13315 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13315 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13315 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13315 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13315 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13315 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13315 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13315 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13315 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13315 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13315 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13315 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13315 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13315 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13315 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13315 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13315 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13315 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13315 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13315 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
|