| Interacting proteins: P54132 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54132 and Q06609 |
Pubmed |
SVM Score :0.75436932 |
| The interaction between BLM and RAD 51 appears to have been evolutionarily conserved since the C terminal domain of Sgs 1 , the Saccharomyces cerevisiae homologue of BLM , interacts with yeast Rad 51 . 0.75436932^^^ |
|
| Interacting proteins: P54132 and Q06609 |
Pubmed |
SVM Score :0.7088864 |
| Biochemical experiments suggested that BLM resides in a nuclear matrix bound complex in which association with hRAD 51 may be direct . 0.7088864^^^ |
|
| Interacting proteins: P54132 and Q06609 |
Pubmed |
SVM Score :1.0920686 |
| Here , we show that BLM also makes a direct physical association with the RAD51L3 protein ( also known as RAD51D ) , a so called RAD 51 paralog that shows limited sequence similarity to RAD 51 itself . 1.0920686^^^ |
|
| Interacting proteins: P54132 and Q06609 |
Pubmed |
SVM Score :0.84462118 |
| BCR / ABL promotes interactions of BLM with RAD 51 , while simultaneous overexpression of BLM and RAD 51 in normal cells increases drug resistance . 0.84462118^^^ |
|
| Interacting proteins: P54132 and Q06609 |
Pubmed |
SVM Score :0.0 |
| The induction of umuC gene expression , cell lethality , induction of W reactivation of UV irradiated lambda phage and the induction of mutagenesis caused by bleomycin ( Blm ) were studied in Escherichia coli K 12 strains with special references to the effects of SOS repair deficiencies . ( 1 ) The umuC gene is inducible by Blm and the induction is regulated by the lexA and recA genes . ( 2 ) The lexA and recA mutants are slightly more sensitive to Blm killing than wild type strain . ( 3 ) The plating efficiency of UV irradiated lambda phage increased by Blm treatment of the host cell . ^^^ The plating efficiency of UV irradiated lambda phage was drastically reduced in the lexA and recA strains treated with Blm . ( 4 ) No significant increase of the reversion of nonsense mutation ( his 4 to His+ ) in AB 1157 by the treatment of Blm was observed . ^^^ |
|
| Interacting proteins: P54132 and Q06609 |
Pubmed |
SVM Score :0.0 |
| BLM protein expression and location are detected by immunofluorescence and immunoelectron microscopy as discrete foci that are sparsely present on early meiotic prophase chromosome cores , later found abundantly on synapsed cores , frequently in combination with the recombinases RAD 51 and DMC 1 , and eventually as pure BLM foci . ^^^ |
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| Interacting proteins: P54132 and Q06609 |
Pubmed |
SVM Score :0.0 |
| We find that BLM preferentially melts those D loops that are formed more favorably by the strand exchange protein Rad 51 , but whose polarity could be less favorable for enabling restoration of an active replication fork . ^^^ |
|
| Interacting proteins: P54132 and Q06609 |
Pubmed |
SVM Score :0.0 |
| Following blockage of DNA replication , Ser ( 15 ) phospho p 53 , BLM , and RAD 51 colocalize in nuclear foci at sites likely to contain DNA replication intermediates in cells . ^^^ |
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| Interacting proteins: P54132 and Q06609 |
Pubmed |
SVM Score :0.0 |
| We show that p 53 and BLM accumulated after hydroxyurea ( HU ) treatment , and physically associated and co localized with each other and with RAD 51 at sites of stalled DNA replication forks . ^^^ HU induced relocalization of BLM to RAD 51 foci was p 53 independent . ^^^ However , BLM was required for efficient localization of either wild type or mutated ( Ser15Ala ) p 53 to these foci and for physical association of p 53 with RAD 51 . ^^^ |
|
| Interacting proteins: P54132 and Q06609 |
Pubmed |
SVM Score :0.0 |
| Here , we describe the recent progress in our understanding of how Rad 51 is involved in the signalling and repair of DNA damage and how tumour suppressors , such as p 53 , ATM , BRCA 1 , BRCA 2 , BLM and FANCD 2 are linked to Rad 51 dependent pathways . ^^^ |
|
| Interacting proteins: P54132 and Q06609 |
Pubmed |
SVM Score :0.0 |
| These abnormalities are not associated with a failure of the BLM T99A / T122A protein to localize to replication foci or to colocalize either with ATR itself or with other proteins that are required for response to DNA damage , such as phosphorylated histone H2AX and RAD 51 . ^^^ |
|
| Interacting proteins: P54132 and Q06609 |
Pubmed |
SVM Score :0.0 |
| Consistent with these observations , hMSH 6 colocalized with BLM and phospho ser 15 p53 in hydroxyurea induced RAD 51 nuclear foci that may correspond to the sites of presumed stalled DNA replication forks and more likely the resultant DNA double stranded breaks . ^^^ In addition , we show that hMSH 2 and hMSH 6 coimmunoprecipitated with BLM , p 53 , and RAD 51 . ^^^ Both the number of RAD 51 foci and the amount of the BLM p 53 RAD51 complex are increased in hMSH 2 or hMSH 6 deficient cells . ^^^ |
|
| Interacting proteins: P54132 and Q06609 |
Pubmed |
SVM Score :0.0 |
| By controlling the balance between the BLM and the RAD 51 pathways , this direct role of p 53 could maintain genome stability when replication forks are stalled at regions of DNA damage . ^^^ |
|
| Interacting proteins: P54132 and Q06609 |
Pubmed |
SVM Score :0.0 |
| The acute sensitivity of recN cells was comparable to that of recA , implying a central role for the RecN protein in BLM lesion repair . ^^^ |
|
| Interacting proteins: P54132 and Q06609 |
Pubmed |
SVM Score :0.0 |
| This band was also completely supershifted by the addition of antibodies to ATM , Ku 70 , DNA ligase 3 , Rpa 32 , Rpa 14 , DNA ligase 4 , XRCC 4 , WRN , BLM , RAD 51 and p 53 . ^^^ The density of one of the DNA EBCs predicted the radiosensitization caused by BRCA haploinsufficiency , and this band contains Ku 70 , ATM , DNA ligase 3 , Rpa 32 , Rpa 14 , DNA ligase 4 , XRCC 4 , WRN , BLM , RAD 51 and p 53 but not BRCA 1 or 2 . ^^^ |
|
| Interacting proteins: P54132 and Q06609 |
Pubmed |
SVM Score :0.0 |
| P 53 may downregulate HR through multiple mechanisms including the reported associations with the Rad 51 and Rad 54 recombinases , and the BLM and WRN helicases . ^^^ |
|
| Interacting proteins: P54132 and Q06609 |
Pubmed |
SVM Score :0.0 |
| To investigate the mechanism of the elevated SCE , we deleted FANCC in cells lacking Rad 51 paralog XRCC 3 , TLS factor RAD 18 , or BLM . ^^^ |
|
| Interacting proteins: P54132 and Q06609 |
Pubmed |
SVM Score :0.0 |
| Rad 51 dependent DNA structures accumulate at damaged replication forks in sgs 1 mutants defective in the yeast ortholog of BLM RecQ helicase . ^^^ |
|
| Interacting proteins: P54132 and Q06609 |
Pubmed |
SVM Score :0.0 |
| Our data suggest that p53pSer15 plays a dual role in the functional interactions with early complexes of Rad 51 dependent recombination and with BLM associated surveillance and signalling complexes within distinct nuclear subcompartments . . ^^^ |
|
| Interacting proteins: P54132 and Q06609 |
Pubmed |
SVM Score :0.0 |
| We show that mobile D loops created by the RecA recombinase are a highly preferred substrate for BLM with the invading strand being displaced from the duplex . ^^^ |
|
| Interacting proteins: P54132 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54132 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54132 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54132 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54132 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54132 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54132 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54132 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54132 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54132 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54132 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54132 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
|