| Interacting proteins: P43246 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43246 and Q06609 |
Pubmed |
SVM Score :0.0 |
| Further , it suggests that the EXO 1 , RAD 51 and MSH 2 genes control independent mechanisms for the maintenance of UV resistance . . ^^^ |
|
| Interacting proteins: P43246 and Q06609 |
Pubmed |
SVM Score :0.0 |
| Furthermore , some Msh 2 null clones expressed high levels of Rad 51 specifically , a critical component of HRR . ^^^ |
|
| Interacting proteins: P43246 and Q06609 |
Pubmed |
SVM Score :0.0 |
| Homologous and homeologous intermolecular gene conversion are not differentially affected by mutations in the DNA damage or the mismatch repair genes RAD 1 , RAD 50 , RAD 51 , RAD 52 , RAD 54 , PMS 1 and MSH 2 . ^^^ Homologous recombination in rad 51 , rad 52 and rad 54 mutants was considerably reduced , while there was little effect of rad 1 , rad 50 , pms 1 and msh 2 null mutations . ^^^ |
|
| Interacting proteins: P43246 and Q06609 |
Pubmed |
SVM Score :0.0 |
| Finally , we demonstrate the specificity of this phenotype by showing that the DNA repair and / or checkpoint mutants mgt 1 delta , mag 1 delta , apn 1 delta , rev 3 delta , rad 18 delta , rad 16 delta , dun 1 delta 100 , sad 4 1 , tel 1 delta , rad 26 delta , rad 51 delta , rad 52 1 , rad 54 delta , rad 14 delta , rad 1 delta , pol 30 46 , pol 30 52 , mad 3 delta , pds 1 delta / esp2 delta , pms 1 delta , mlh 1 delta , and msh 2 delta are all proficient at S phase regulation , even though some of these mutations confer sensitivity to alkylation . . ^^^ |
|
| Interacting proteins: P43246 and Q06609 |
Pubmed |
SVM Score :0.0 |
| We find that transposition is elevated in cells mutated for genes in the RAD 52 recombinational repair pathway , such as RAD 50 , RAD 51 , RAD 52 , RAD 54 , or RAD 57 , or in the DNA ligase 1 gene CDC 9 , but is not elevated in cells mutated in the DNA repair functions encoded by the RAD 1 , RAD 2 , or MSH 2 genes . ^^^ |
|
| Interacting proteins: P43246 and Q06609 |
Pubmed |
SVM Score :0.0 |
| The DNA synthesis , repair , and recombination genes ( nine genes ) were the DNA replication licensing factor MCM 4 , the DNA replication licensing factor MCM 5 , the DNA mismatch repair gene PMS 2 , the DNA excision repair gene , the DNA mismatch repair gene MSH 2 , the ultraviolet excision repair gene Rad 23 DNA ligase 1 , Rad 51 , and Rad 52 . ^^^ |
|
| Interacting proteins: P43246 and Q06609 |
Pubmed |
SVM Score :0.0 |
| Furthermore , MSH 2 ( / ) cells displayed an elevated spontaneous RAD 51 focus forming activity and a higher induction of RAD 51 foci following camptothecin treatment . ^^^ Thus , the absence of MSH 2 could result in both spontaneous DNA damage and uncontrolled recombination events leading to the observed higher yield of chromosomal damage and the higher induction of RAD 51 foci following CPT treatment . ^^^ Therefore , our results suggest an involvement of MSH 2 in the early events leading to correct RAD 51 relocalization after the formation of DSBs specifically produced at the blocked replication fork . . ^^^ |
|
| Interacting proteins: P43246 and Q06609 |
Pubmed |
SVM Score :0.0 |
| Interestingly , 10 repair genes ( RAD 51 , RAD 54 , CDC 8 , MSH 2 , RFA 2 , RFA 3 , UBC 5 , SRS 2 , SPO 12 and TOP 1 ) , involved in recombination and DNA synthesis , display similar regulation of expression in the two irradiated populations . ^^^ |
|
| Interacting proteins: P43246 and Q06609 |
Pubmed |
SVM Score :0.0 |
| These p 53 and MSH 2 foci also show significant overlaps with foci of the recombination enzymes Rad 50 and Rad 51 , which for the first time unveiled recombination related functions of p 53 in replicating cells . ^^^ |
|
| Interacting proteins: P43246 and Q06609 |
Pubmed |
SVM Score :0.0 |
| The mammalian mismatch repair protein MSH 2 is required for correct MRE 11 and RAD 51 relocalization and for efficient cell cycle arrest induced by ionizing radiation in G 2 phase . ^^^ Cell survival , checkpoint functions and relocalization of the recombination related proteins MRE 11 and RAD 51 were analysed in embryonic fibroblasts derived from MSH 2 ( + / + ) and MSH 2 ( / ) mice , and in MSH 2 proficient and deficient mouse colorectal carcinoma cells . ^^^ Loss of MSH 2 function was found to be associated with reduction in cell survival following radiation , absence of either MRE 11 or RAD 51 relocalization and a higher level of 10 ray induced chromosomal damage specifically in G 2 phase cells . ^^^ |
|
| Interacting proteins: P43246 and Q06609 |
Pubmed |
SVM Score :0.0 |
| Whereas the requirements for the MutS homolog , MSH 2 , and the MutL homolog , MLH 1 , in the suppression of homeologous recombination were similar in rad 51 strains , the loss of MSH 2 caused a greater loss in homeologous recombination suppression than did the loss of MLH 1 in a rad 59 strain . ^^^ |
|
| Interacting proteins: P43246 and Q06609 |
Pubmed |
SVM Score :0.0 |
| In this report , we analysed the regulation of expression of mammalian MSH 2 , MSH 3 and MLH 1 genes involved in mismatch repair , and Rad 51 and Rad 50 genes involved in homologous recombination repair , in relation to cell growth . ^^^ The expression of MSH 2 , MLH 1 and Rad 51 genes was clearly growth regulated , whereas MSH 3 and Rad 50 genes were constitutively expressed , suggesting differential requirement of the repair gene products for cell proliferation . ^^^ |
|