| Interacting proteins: P40692 and Q06609 |
Pubmed |
SVM Score :0.0 |
| Twelve loci of selected DNA repair genes were genotyped by matrix assisted laser desorption / ionization time of flight mass spectrometry ( XRCC 2 Arg188His , XRCC 4 921G > T , XRCC 6 1796G > T , LIG 4 1977T / C , RAD 51 135G > C , 172G > T , RAD 52 2259C > T , LIG 1 551A > C , ERCC 1 8092A > C , 354C > T , hMLH 1 93G > A , and Ile219Val ) . ^^^ |
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| Interacting proteins: P40692 and Q06609 |
Pubmed |
SVM Score :0.0 |
| Finally , we demonstrate the specificity of this phenotype by showing that the DNA repair and / or checkpoint mutants mgt 1 delta , mag 1 delta , apn 1 delta , rev 3 delta , rad 18 delta , rad 16 delta , dun 1 delta 100 , sad 4 1 , tel 1 delta , rad 26 delta , rad 51 delta , rad 52 1 , rad 54 delta , rad 14 delta , rad 1 delta , pol 30 46 , pol 30 52 , mad 3 delta , pds 1 delta / esp2 delta , pms 1 delta , mlh 1 delta , and msh 2 delta are all proficient at S phase regulation , even though some of these mutations confer sensitivity to alkylation . . ^^^ |
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| Interacting proteins: P40692 and Q06609 |
Pubmed |
SVM Score :0.0 |
| Several of the proteins examined have been implicated in repair / recombination and include RAD 51 , a mammalian homolog of the Escherichia coli RecA protein ; Replication Protein A ( RPA ) , a single strand DNA binding protein ; and MLH 1 , a mismatch repair protein which is a homolog of the E . coli MutL protein . ^^^ |
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| Interacting proteins: P40692 and Q06609 |
Pubmed |
SVM Score :0.0 |
| Accompanying cytological studies with fluorescent antibodies indicated that while there was no detectable effect on the number of recombination nodules ( MLH 1 foci ) , there were marked changes in the stage of appearance and localization of RAD 51 and RPA proteins . ^^^ |
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| Interacting proteins: P40692 and Q06609 |
Pubmed |
SVM Score :0.0 |
| This included prolonged association of gammaH2AX with sites of DNA damage , reduced sex body formation , diminished Rad 51 foci and absence of Mlh 1 foci in the pachytene stage . ^^^ |
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| Interacting proteins: P40692 and Q06609 |
Pubmed |
SVM Score :0.0 |
| However , the localization of Rad 51 , Brca 1 , Fancd 2 and Mlh 1 appeared normal on Fanca ( tm1Hsc ) homozygous meiotic chromosomes . ^^^ |
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| Interacting proteins: P40692 and Q06609 |
Pubmed |
SVM Score :0.0 |
| Whereas the requirements for the MutS homolog , MSH 2 , and the MutL homolog , MLH 1 , in the suppression of homeologous recombination were similar in rad 51 strains , the loss of MSH 2 caused a greater loss in homeologous recombination suppression than did the loss of MLH 1 in a rad 59 strain . ^^^ |
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| Interacting proteins: P40692 and Q06609 |
Pubmed |
SVM Score :0.0 |
| In this report , we analysed the regulation of expression of mammalian MSH 2 , MSH 3 and MLH 1 genes involved in mismatch repair , and Rad 51 and Rad 50 genes involved in homologous recombination repair , in relation to cell growth . ^^^ The expression of MSH 2 , MLH 1 and Rad 51 genes was clearly growth regulated , whereas MSH 3 and Rad 50 genes were constitutively expressed , suggesting differential requirement of the repair gene products for cell proliferation . ^^^ Promoter analysis showed that the growth regulated expression of MLH 1 and Rad 51 genes was mainly mediated by E2F that plays crucial roles in regulation of DNA replication , suggesting close relation between some of the repair genes and DNA replication . . ^^^ |
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| Interacting proteins: P40692 and Q06609 |
Pubmed |
SVM Score :0.0 |
| We propose that ASCIZ acts as a lesion specific focus scaffold in a Rad 51 dependent pathway that resolves cytotoxic repair intermediates , most likely single stranded DNA gaps , resulting from MLH 1 dependent processing of base lesions . . ^^^ |
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| Interacting proteins: P40692 and Q06609 |
Pubmed |
SVM Score :0.0 |
| To date , immunocytology has been used in humans to detect a limited number of meiotic proteins : components of the synaptonemal complex ( SCP 1 and SCP 3 ) and some proteins known to participate in recombination events , such as MLH 1 or RAD 51 . ^^^ This work reports the relative timing and localization of five different meiotic proteins that have previously been implicated in human homologous recombination [ RAD 51 , replication protein A ( RPA ) , MSH 4 , MLH 1 and MLH 3 ] . ^^^ |
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| Interacting proteins: P40692 and Q06609 |
Pubmed |
SVM Score :0.0 |
| Fluorescent immunolocalization of meiotic proteins showed normal SYCP 3 , scarcity of SYCP 1 , null MLH 1 foci , about 10 patches of gamma H2AX , abnormal presence of BRCA 1 among autosomal axes , absence of RAD 51 in early and advanced spermatocytes and permanence of gamma H2AX labelling up to the abnormal spermatocyte divisions that are the most advanced stage reached . ^^^ |
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| Interacting proteins: P40692 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40692 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40692 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40692 and Q06609 |
Pubmed |
SVM Score :0.0 |
| NA |
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