| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.80016785 |
| Human Rad 51 ( hRad 51 ) has been found to be associated with BRCA 1 , BRCA 2 , and p 53 either directly or indirectly and is one of at least eight human genes that are members of the Escherichia coli RecA / Saccharomyces cerevisiae Rad 51 family thought to affect genomic stability through DNA recombination / repair processes . 0.80016785^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.67414237 |
| Association of BRCA 1 with Rad 51 in mitotic and meiotic cells . 0.67414237^^^ These findings suggest a functional interaction between BRCA 1 and Rad 51 in the meiotic and mitotic cell cycles , which , in turn , suggests a role for BRCA 1 in the control of recombination and of genome integrity . . 0.52386714^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :1.2522362 |
| The proposition that BRCA 1 might play a role as a caretaker of the genome was first put forward by the demonstration that , in mitotic and meiotic cells , BRCA 1 can interact with Rad 51 , which plays a major role in repair and / or recombination processes . 1.2522362^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :1.0917592 |
| The proposition that BRCA 1 may play a role as a caretaker of the genome , was first put forward by the demonstration that , in mitotic and meiotic cells , BRCA 1 can interact with Rad 51 , a major actor in repair and / or recombination processes . 1.0917592^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.55673571 |
| Based on its amino acid sequence and the existence of three nuclear localization signal ( NLS ) 3 regions , BRCA 1 is likely to be a cell cycle dependent nuclear protein , regulated by cyclin dependent kinases ( cdk ) and associated with nuclear proteins such as Rad 51 and BARD 1 , involved in transcription regulation and participating in DNA replication checkpoints . 0.55673571^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| Immunofluorescence microscopy revealed that hRad54B formed nuclear foci that colocalized with hRad 51 , hRad 54 , and BRCA 1 . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| The studies summarized here suggest that BRCA 1 , BRCA 2 , RAD 51 . and BARD 1 function as a biochemical complex . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| In human cells , BRCA 1 binds to both Rad 50 and Rad 51 and colocalizes with these proteins at repair foci . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| The association of BRCA 1 with RAD 51 has led to the hypothesis that BRCA 1 is involved in DNA repair . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| We have isolated a holoenzyme complex termed BRCC containing BRCA 1 , BRCA 2 , and RAD 51 . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| These include genes already known to interact with BRCA 1 such as CDKN1B , ATR , and RAD 51 . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| BRCA 1 , Rad 51 , and CHK 2 contribute to recombinational repair , in part independently of H2AX . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| Rad 51 , Rad 52 , Rad 54 , BRCA 1 , BRCA 2 ) in both normal and malignant cultures . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| XRCC 3 is one out of five RAD 51 paralogues and is involved in homologous recombination , as are the BRCA 1 and BRCA 2 proteins . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| Knockdown of BRCA 1 expression reduces ssDNA and Rad 51 foci formation in response to ionizing radiation . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| BRCA 1 and BRCA 2 account for most cases of familial , early onset breast and / or ovarian cancer and encode products that each interact with hRAD 51 . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| The two major hereditary breast cancer susceptibility genes , BRCA 1 and BRCA 2 , are associated with early onset breast and / or ovarian cancer and encode products that each interact with the product of the eukaryotic RecA homologue , hRad 51 . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| Among the BRCA 1 interactive proteins are hRAD 51 ( a human homologue of Escherichia coli rec A protein ) , BARD 1 ( BRCA 1 associated RING domain 1 ) and p 53 , all of which are involved in DNA repair . ^^^ We have analyzed the expression patterns of the hRAD 51 , BARD 1 and p 53 proteins in five breast cancer cell lines , including a BRCA 1 deficient cell line , and in 179 breast cancer tissue samples from Japanese women , including 113 sporadic , 47 hereditary ( i . e . , BRCA 1 status unknown ) , and 19 BRCA 1 associated cases . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| The functions of the proteins encoded by BRCA 1 and BRCA 2 remain to be elucidated , but their interaction and colocalization with hRAD 51 suggest a role in homologous recombination and DNA double strand break ( DSB ) repair . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| These efforts have already uncovered two interacting proteins : the BRCA 1 associated RING domain ( BARD 1 ) protein , a novel polypeptide that bears a striking structural resemblance to BRCA 1 , and hRAD 51 , a human homolog of the bacterial recA gene product . ^^^ As proliferating cells enter S phase of the cell cycle , the BRCA 1 , hRAD 51 , and BARD 1 polypeptides aggregate in discrete nuclear domains , commonly described as `` BRCA 1 nuclear dots ' ' . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| ERCC 1 , hRad 51 , and BRCA 1 protein expression in relation to tumour response and survival of stage III / IV NSCLC patients treated with chemotherapy . ^^^ Aim of this explorative study was to determine the prognostic value of protein expression of the DNA damage repair enzymes ERCC 1 , hRad 51 , and BRCA 1 for tumour response and survival of non small cell lung cancer patients treated with chemotherapy . ^^^ Tumour biopsies were assessed for differences in immunohistochemical staining using antibodies against ERCC 1 , hRad 51 , and BRCA 1 . ^^^ A positive nuclear staining for ERCC 1 , hRad 51 , and BRCA 1 was observed in 44 , 12 , and 90 % of biopsies , respectively . ^^^ In conclusion , immunohistochemical staining of ERCC 1 , hRad 51 , and BRCA 1 , in tumour biopsies from non small cell lung cancer patients was not predictive for tumour response and survival after chemotherapy . . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| The interaction of HsRad 51 with several tumor suppressor genes namely p 53 , BRCA 1 and BRCA 2 implies possible role ( s ) of this protein in tumorigenesis . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| During S phase of the cell cycle , BRCA 1 polypeptides are found in discrete nuclear bodies ( ' BRCA1 nuclear dots ' ) together with HsRad 51 , a human homolog of the E . coli recA protein , and BARD 1 , a protein that interacts with BRCA 1 to form a stable heterodimer . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| The first clue of an interaction between HsRad 51 and BRCA 1 came from the colocalization of the characteristic nuclear foci formed by these two proteins during S phase of the cell cycle . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| RAD 51 interacts with proteins involved in recombination and also with tumor suppressor proteins p 53 and breast cancer susceptibility gene 1 ( BRCA 1 ) . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| BARD 1 and Rad 51 , two proteins associated with the BRCA 1 dots , behaved similarly . ^^^ Finally , after BRCA 1 dot dispersal , BRCA 1 , BARD 1 , and Rad 51 accumulated , focally , on PCNA+ replication structures , implying an interaction of BRCA1 / BARD1 / Rad51 containing complexes with damaged , replicating DNA . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| The nuclear protein BRCA 1 has the properties of a transcription factor , and can interact with the recombination and repair protein RAD 51 . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| A recent report that BRCA 1 and human Rad 51 colocalize in S phase cells suggests a role for BRCA 1 in DNA damage repair . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| The involvement of abnormalities of the BRCA 1 gene in breast cancers in Japanese patients without any family history of this cancer was investigated by polymerase chain reaction based single strand conformation polymorphism analysis of the DNA sequences corresponding to the zinc finger domain ( exons 2 , 3 and 5 ) and the binding domain with Rad 51 ( exon 11 ) of the BRCA 1 protein . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| Wild type BRCA 1 protein binds to a number of cellular proteins , including DNA repair protein Rad 51 , tumor suppressor p 53 , RNA polymerase 2 holoenzyme , RNA helicase A , CtBP interacting protein , c myc , BRCA 1 associated RING domain protein ( BARD 1 ) , BRCA 2 protein , etc . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| Coordinate alterations in the expression of BRCA 1 , BRCA 2 , p 300 , and Rad 51 in response to genotoxic and other stresses in human prostate cancer cells . ^^^ The purpose of this study was to evaluate the effects of genotoxic and other cytotoxic agents on expression of DNA damage response genes ( BRCA 1 , BRCA 2 , p 300 , and Rad 51 ) in human prostate cancer cells . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| Association of breast tumor susceptibility gene products BRCA 1 and BRCA 2 with the RAD 51 recombination protein suggested that cancer could arise through defects in recombination . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| Association of a recombinational repair protein RAD 51 with tumor suppressors BRCA 1 and BRCA 2 suggests that defects in homologous recombination are responsible for tumor formation . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| Both BRCA 1 and BRCA 2 have been reported to bind Rad 51 , a protein essential for homologous recombination and the recombinational repair of DNA double strand breaks . ^^^ Here we demonstrate that IR induced Rad 51 foci formation is aberrant in BRCA 2 but not BRCA 1 deficient tumor cells . ^^^ In HCC 1937 cells , which harbor mutation of BRCA 1 , IR induced Rad 51 foci were readily detected . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| The physical interactions among the products of RAD 51 , BRCA 1 , and BRCA 2 have suggested that the BRCA 1 and BRCA 2 breast cancer susceptibility genes may function , at least in part , in this DNA damage repair pathway . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| Detection of loss of heterozygosity at RAD 51 , RAD 52 , RAD 54 and BRCA 1 and BRCA 2 loci in breast cancer : pathological correlations . ^^^ Loss of heterozygosity ( LOH ) in loci of the 15q15 . 1 , 12p13 , 1p32 , 17q21 and 13q12 13 regions may collaborate in the inactivation of RAD 51 , RAD 52 , RAD 54 , BRCA 1 , BRCA 2 and possibly other genes implicated in the repair of double stranded DNA and in DNA recombination . ^^^ We investigate allelic losses in microsatellites of the RAD 51 , RAD 52 , RAD 54 , BRCA 1 and BRCA 2 regions , and their correlations with nine pathologic parameters in 127 breast carcinomas . ^^^ LOH was found in the RAD 51 region in 32 % of tumours , in the RAD 52 region in 16 % , in RAD 54 in 20 % and in the BRCA 1 and BRCA 2 regions in 49 % and 44 % respectively . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| Whereas most mutations in BRCA 1 and BRCA 2 are known to affect the more carboxy terminal regions interacting with RAD 51 , and the transactivating BRCT domains of BRCA 1 , this is the first demonstration of a recurrent BRCA 2 mutation that specifically deletes the amino terminal transactivation domain . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| Evidence that BRCA 1 is involved in DNA repair stems from its association with RAD 51 , a homolog of the yeast protein involved in the repair of DNA double strand breaks ( DSBs ) by homologous recombination . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| In alpha particle irradiated cells and in those cells subsequently cultured in the presence of E , increased BRCA 1 , BRCA 2 and RAD 51 expression were detected by immunofluorescence staining and quantified by confocal microscopy . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| BRCA 1 and BRCA 2 proteins form a complex with Rad 51 , and these genes are thought to participate in a common DNA damage response pathway associated with the activation of homologous recombination and double strand break repair . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| The breast cancer susceptibility gene BRCA 1 is required for subnuclear assembly of Rad 51 and survival following treatment with the DNA cross linking agent cisplatin . ^^^ Immunoflourescence studies with normal and brca 1 ( / ) mutant mouse ES cell lines indicate that Brca 1 promotes assembly of subnuclear Rad 51 foci following both types of DNA damage . ^^^ Our studies suggest that Brca 1 contributes to damage repair and / or tolerance by promoting assembly of Rad 51 . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| BRCA 1 contains several functional domains that interact directly or indirectly with a variety of molecules , including tumor suppressors ( p 53 , RB , BRCA 2 and ATM ) , oncogenes ( c Myc , casein kinase 2 and E2F ) , DNA damage repair proteins ( RAD 50 and RAD 51 ) , cell cycle regulators ( cyclins and cyclin dependent kinases ) , transcriptional activators and repressors ( RNA polymerase 2 , RHA , histone deacetylase complex and CtIP ) and others . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| The product of the tumor suppressor gene BRCA 1 also colocalized with gamma H2AX and was recruited to these sites before Rad 50 or Rad 51 . ^^^ CONCLUSIONS : The pattern of gamma H2AX foci that is established within a few minutes of DNA damage accounts for the patterns of Rad 50 , Rad 51 , and Brca 1 foci seen much later during recovery from damage . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| BRCA 1 is part of a multiprotein complex , which also contains the recombination factor Rad 51 . ^^^ Here we describe that in contrast to BRCA 1 , histological grading of sporadic invasive ductal breast cancer significantly correlates with over expression of wild type Rad 51 . ^^^ These data suggest that in addition to the absence of the tumour suppressor protein BRCA 1 , over expression of wild type Rad 51 also contributes to the pathogenesis of a significant percentage of sporadic breast cancers and that other mechanisms than mutations must be responsible for this altered expression . . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| A single nucleotide polymorphism in the RAD 51 gene modifies cancer risk in BRCA 2 but not BRCA 1 carriers . ^^^ The BRCA 1 and BRCA 2 proteins function in DNA repair in conjunction with RAD 51 . ^^^ A preliminary report suggested that a single nucleotide polymorphism in the 5 ' untranslated region of RAD 51 ( 135C / G ) increases breast cancer risk in BRCA 1 and BRCA 2 carriers . ^^^ Among BRCA 1 carriers , RAD 51 135C frequency was similar in healthy and affected women [ 6 . 1 % ( 3 of 49 ) and 9 . 9 % ( 12 of 121 ) , respectively ] , and RAD 135C did not influence age of cancer diagnosis [ Hazard ratio ( HR ) = 1 . 18 for disease in RAD 51 135C heterozygotes , not significant ] . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| Brca 1 is hyperphosphorylated in response to DNA damage and co localizes with Rad 51 , a protein involved in homologous recombination , and Nbs1 . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| Our results demonstrate that full length murine Brca 1 is identical to human BRCA 1 with respect to its cell cycle regulation , DNA damage induced phosphorylation , nuclear localization , and association with Rad 51 . ^^^ However , we further show that DNA damage induced phosphorylation of Brca 1 Delta11 is significantly reduced compared to full length Brca 1 , and that gamma irradiation induced Rad 51 focus formation is impaired in cells in which only Brca 1 Delta11 is expressed . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| The protein products of the hereditary breast cancer susceptibility genes , BRCA 1 and BRCA 2 , interact with the Rad 51 protein , a central component of homologous repair pathways . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| We find that murine Brca 2 shares multiple properties with human BRCA 2 including its regulation during the cell cycle , localization to nuclear foci , and interaction with Brca 1 and Rad 51 . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| RAD 51 colocalizes with both BRCA 1 and BRCA 2 , and genetic variants in RAD 51 would be candidate BRCA1 / 2 modifiers . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| RESULTS : BRCA 1 and BRCA 2 are likely to act as tumor suppressor genes , and together with RAD 51 operate in a common DNA damage response pathway implicated in double strand repair . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| As RAD 51 is implicated in BRCA 1 and BRCA 2 mediated tumor suppression as well as cellular viability , we have begun a functional analysis of a defined RAD 51 mutation in mammalian cells . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| The role of the Fanconi anaemia genes in DNA repair was examined by a quantitative analysis of nuclear DNA repair foci in FA primary fibroblasts after ionising irradiation using antibodies directed against RAD 51 , MRE 11 and BRCA 1 for visualisation . ^^^ Correction of FA A , FA C and FA G cells by retroviral cDNA transfer specifically corrected the RAD 51 foci response but did not affect formation of foci containing BRCA 1 or MRE 11 . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| Here , we show that under identical cell free reaction conditions , the addition of antibodies specific for BRCA 1 and Rad 50 but not Rad 51 , inhibits end joining activity . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| S phase specific interaction of the Fanconi anemia protein , FANCD 2 , with BRCA 1 and RAD 51 . ^^^ Monoubiquitinated FANCD 2 colocalizes with BRCA 1 and RAD 51 in S phase specific nuclear foci . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| Moreover , we show that the formation of foci , including BRCA 1 and / or RAD 51 proteins , is significantly delayed in FA cells . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| The breast cancer associated BRCA 1 and BRCA 2 proteins are strongly implicated in HRR ; BRCA 2 associates with Rad 51 and appears to regulate its activity . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| Furthermore , human Snm 1 foci formed after ionizing radiation were largely coincident with foci formed by human Mre 11 and to a lesser extent with those formed by BRCA 1 , but not with those formed by human Rad 51 . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| To facilitate association based linkage studies we have studied the linkage disequilibrium ( LD ) and haplotype architecture around five genes of interest for cancer risk : ATM , BRCA 1 , BRCA 2 , RAD 51 , and TP 53 . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| Because the Fanconi anemia alleles of BRCA 2 fail to bind to Rad 51 in response to genotoxic stress and Rad 51 therefore fails to localize to nuclear damage foci , many investigators in the field suspect that the Fanconi anemia pathway supports the integrity of the Rad 51 and BRCA 1 and BRCA 2 pathways as they function in homologous recombination repair . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| BRCA 1 also acts as a scaffold for the assembly of ATPases such as Rad 51 , responsible for the somatic homologous recombination . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| The breast cancer suppressor proteins BRCA 1 and BRCA 2 interact with RAD 51 , a protein essential for maintaining genomic stability by playing a central role in homology dependent recombinational repair of the DNA double strand breaks . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| Breast cancer risk reduction associated with the RAD 51 polymorphism among carriers of the BRCA 1 5382insC mutation in Poland . ^^^ The product of the RAD 51 gene functions with BRCA 1 and BRCA 2 in the repair of double stranded DNA breaks . ^^^ To establish whether polymorphic variation of RAD 51 modifies risk for hereditary breast cancer , we conducted a matched case control study on 83 pairs of female carriers of the BRCA 1 5382insC mutation . ^^^ The RAD 51 135C allele was detected in 37 % of unaffected and in 17 % of affected BRCA 1 carriers . ^^^ This finding suggests that RAD 51 is a genetic modifier of breast cancer risk in BRCA 1 carriers in the Polish population . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| Association of the BRCA 1 protein with the DNA repair protein Rad 51 and changes in the phosphorylation and cellular localization of the protein after exposure to DNA damaging agents are consistent with a role for BRCA 1 in DNA repair . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| PAT Plat was found to result in an extra number of slowly repairable DNA double strand breaks , inhibition of DNA protein kinase activity , dramatic nuclear relocalization of RAD 51 , hyperphosphorylation of the BRCA 1 protein , and activation of proto oncogenic c Abl tyrosine kinase . . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| However , the localization of Rad 51 , Brca 1 , Fancd 2 and Mlh 1 appeared normal on Fanca ( tm1Hsc ) homozygous meiotic chromosomes . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| Here , we describe the recent progress in our understanding of how Rad 51 is involved in the signalling and repair of DNA damage and how tumour suppressors , such as p 53 , ATM , BRCA 1 , BRCA 2 , BLM and FANCD 2 are linked to Rad 51 dependent pathways . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| A single nucleotide polymorphism in the RAD 51 gene modifies breast cancer risk in BRCA 2 carriers , but not in BRCA 1 carriers or noncarriers . ^^^ The RAD 51 gene , which participates in homologous recombination double strand breaks ( DSB ) repair in the same pathway as the BRCA 1 and BRCA 2 gene products , is a candidate for such an effect . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| BRCA 1 , BRCA 2 , ER alpha , ER beta , p 53 , p 21 ( waf1 / cip1 ) , CBP / P300 , RAD 51 , pS 2 and Ki 67 mRNA were quantified using real time quantitative RT PCR with an ABI 7700 apparatus . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| For example , conventional deletion of ATR , Chk 1 , Mad 2 , NBS , Rad 50 , BRCA 1 , BRCA 2 , or Rad 51 leads to developmental arrest prior to gastrulation . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| In particular , BRCA 1 functions in concert with Rad 51 , BRCA 2 and other genes to control double strand break repair ( DSBR ) and homologous recombination . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| The density of one of the DNA EBCs predicted the radiosensitization caused by BRCA haploinsufficiency , and this band contains Ku 70 , ATM , DNA ligase 3 , Rpa 32 , Rpa 14 , DNA ligase 4 , XRCC 4 , WRN , BLM , RAD 51 and p 53 but not BRCA 1 or 2 . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| In response to DNA damaging agents , and during S phase of the cell cycle , the FA pathway is activated via the mono ubiquitination of FANCD 2 ( FANCD 2 Ub ) , signaling its translocation to discrete nuclear foci , where it co localizes with the central DNA repair proteins BRCA 1 and RAD 51 . ^^^ |
|
| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| FA gene products have been shown to functionally or physically interact with BRCA 1 , RAD 51 and the MRE11 / RAD50 / NBS1 complex , suggesting that the FA complex may be involved in the repair of DNA double strand breaks ( DSBs ) . ^^^ Cells lacking Fanca exhibit increased chromosomal aberrations and attenuated accumulation of Brca 1 and Rad 51 foci in response to DNA damage . ^^^ |
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| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| Up to 1 , 600 cases and 4 , 241 controls from 4 separate genetic association studies from 3 countries were genotyped for 13 single nucleotide polymorphisms ( SNP ) in 6 genes ( BRCA 1 , NBS 1 , RAD 51 , RAD 52 , XRCC 2 and XRCC 3 ) involved in homologous recombination of DNA double strand breaks . ^^^ No association was detected between EOC risk and BRCA 1 Q356R , BRCA 1 P871L , RAD 51 g135c , RAD 51 g172t , RAD 52 c2259t , NBS 1 L34L , NBS 1 E185Q , NBS 1 A399A , NBS 1 P672P , XRCC 2 g4324c , XRCC 2 c41657t and XRCC 3 T241M . ^^^ |
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| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| The carboxyl terminal of BRCA 1 is required for subnuclear assembly of RAD 51 after treatment with cisplatin but not ionizing radiation in human breast and ovarian cancer cells . ^^^ Although it is known that BRCA 1 and RAD 51 form distinct DNA repair subnuclear complexes , or foci , following environmental insults to the DNA , the role of BRCA 1 in this process remains to be characterized . ^^^ The purpose of the study was therefore to determine the role of BRCA 1 in the formation of RAD 51 foci following treatment with cisplatin and ionizing radiation . ^^^ We found that although a functional BRCA 1 is required for the subnuclear assembly of BRCA 1 foci following treatment with either ionizing radiation or cisplatin , a functional BRCA 1 is required for RAD 51 foci to form following treatment with cisplatin but not with ionizing radiation . ^^^ These results suggest that the carboxyl terminal of BRCA 1 is required for the cisplatin induced recruitment of RAD 51 to the DNA damage site , which may contribute to cisplatin resistance . . ^^^ |
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| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| MDC 1 forms a complex with Rad 51 through a direct interaction with the forkhead associated domain of MDC 1 , not the BRCA 1 C terminal domain . ^^^ |
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| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| The proteins involved in FA act coordinately in the cellular response to DNA cross links in a pathway that has been shown to interact physically or functionally with a variety of other proteins involved in DNA repair or cell cycle control , notably BRCA 1 , Rad 51 , ATM , ATR , and Nbs 1 . ^^^ |
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| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| BRCA 1 regulates RAD 51 function in response to DNA damage and suppresses spontaneous sister chromatid replication slippage : implications for sister chromatid cohesion , genome stability , and carcinogenesis . ^^^ Whereas BRCA 2 interacts directly with and regulates RAD 51 , the role of BRCA 1 in this process is unclear . ^^^ However , BRCA 1 may regulate RAD 51 in response to DNA damage or through its ability to interact with and regulate MRE11 / RAD50 / NBS1 ( MRN ) during the processing of DSBs into single strand DNA ( ssDNA ) ends , prerequisite substrates for RAD 51 , or both . ^^^ To test these hypotheses , we measured the effect of BRCA 1 on the competition between RAD 51 mediated homologous recombination ( gene conversion and crossover ) versus RAD 51 independent homologous recombination [ single strand annealing ( SSA ) ] for ssDNA at a site specific chromosomal DSB within a DNA repeat , a substrate for both homologous recombination pathways . ^^^ In addition , BRCA 1 also suppressed both spontaneous gene conversion and deletion events , which can arise from either crossover or sister chromatid replication slippage ( SCRS ) , a RAD 51 independent process . ^^^ |
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| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| We predict that BRCA 1 regulates the BACH 1 helicase activity to coordinate the timely displacement of Rad 51 from nucleofilaments , promoting error free repair and ultimately maintaining chromosomal integrity . . ^^^ |
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| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| Through its interactions with the checkpoint kinase 2 ( Chk 2 ) kinase and Rad 51 , BRCA 1 promotes homologous recombination , which is typically an error free repair process . ^^^ |
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| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| The different genes involved in the BRCA 1 and BRCA 2 pathways ( GADD45A , BARD 1 , JUN , BAX , RB 1 , ERalpha , ERbeta , BAP 1 , TNFalpha , p 53 , p21Waf1 / Cip1 , p 300 , RAD 51 , pS 2 , Ki 67 ) were quantified by real time quantitative RT PCR , using the TaqMan method and an ABI Prism 7700 Sequence Detector ( Applied Biosystems ) . ^^^ |
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| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| Germline BRCA 1 mutations and G / C polymorphism in the 5 ' untranslated region of the RAD 51 gene in Polish women with breast cancer . ^^^ In the present work the distribution of genotypes and frequency of alleles of the RAD 51 G / C polymorphism and the frequency of BRCA 1 germ line mutations in patients with breast cancer were investigated . ^^^ |
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| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| Fluorescent immunolocalization of meiotic proteins showed normal SYCP 3 , scarcity of SYCP 1 , null MLH 1 foci , about 10 patches of gamma H2AX , abnormal presence of BRCA 1 among autosomal axes , absence of RAD 51 in early and advanced spermatocytes and permanence of gamma H2AX labelling up to the abnormal spermatocyte divisions that are the most advanced stage reached . ^^^ |
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| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| The results showed association of Rad 51 , Rad 54 , BRCA 1 and BRCA 2 , but not Rad51C , with the nuclear matrix fraction in response to double strand breaks induction . ^^^ |
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| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| We analyzed 49 SNPs in BRCA 1 , BRCA 2 , ESR 1 , XRCC 1 , XRCC 2 , XRCC 3 , NBN , RAD 51 , RAD 52 , LIG 4 , ATM , BCL 2 , TGFB 1 , MSH 6 , ERCC 2 , XPF , NR3C1 , CYP1A1 , CYP2C9 , CYP2C19 , CYP3A5 , CYP2D6 , CYP11B2 , and CYP17A1 genes using the Pyrosequencing technique . ^^^ |
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| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| FA proteins interact with various proteins involved in DNA damage response and cell cycle checkpoint regulation , such as : RAD 51 , BRCA 1 , BRCA 2 , ATM or NBS 1 . ^^^ |
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| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| RAD 51 interacts directly or indirectly with a number of proteins implicated in breast cancer , such as BRCA 1 and BRCA 2 . ^^^ Similar to BRCA 1 mice , RAD 51 / mice are embryonic lethal . ^^^ |
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| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| Monoubiquitinated FANCD 2 translocates to damage induced nuclear foci containing BRCA 1 , BRCA 2 , and Rad 51 , thereby protecting the genome . ^^^ |
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| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| Analysis of RAD 51 polymorphism and BRCA 1 mutations in Polish women with breast cancer . ^^^ The objectives of this study were to determine the frequency of BRCA 1 germ line mutations and the RAD 51 G / C polymorphism in patients with breast cancer . ^^^ |
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| Interacting proteins: Q06609 and P38398 |
Pubmed |
SVM Score :0.0 |
| BRCA 2 tumors present a phenotype opposite to BRCA 1 tumors but very similar to sporadic tumors , except that BRCA 2 overexpress some DNA repair markers such as CHEK 2 , show high cytoplasmic expression of RAD 51 , and are negative for HER 2 amplification and expression . ^^^ |
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