| Interacting proteins: Q06609 and P35568 |
Pubmed |
SVM Score :0.0 |
| Following T antigen mediated nuclear translocation , IRS 1 binds Rad 51 at the site of damaged DNA . ^^^ |
|
| Interacting proteins: Q06609 and P35568 |
Pubmed |
SVM Score :0.0 |
| We have established a functional link between XRCC 2 and RAD 51 by looking at damage dependent RAD 51 focus formation in the irs 1 cell line . ^^^ Little or no formation of RAD 51 foci occurred in irs 1 . ^^^ |
|
| Interacting proteins: Q06609 and P35568 |
Pubmed |
SVM Score :0.0 |
| Role of the insulin like growth factor I / insulin receptor substrate 1 axis in Rad 51 trafficking and DNA repair by homologous recombination . ^^^ This effect involves an interaction between Rad 51 and the major IGF IR signaling molecule , insulin receptor substrate 1 ( IRS 1 ) . ^^^ In the absence of IGF 1 stimulation , or if mutated IGF IR fails to phosphorylate IRS 1 , localization of Rad 51 to the sites of damaged DNA is diminished . ^^^ |
|
| Interacting proteins: Q06609 and P35568 |
Pubmed |
SVM Score :0.0 |
| We expressed the RAD 51 dominant negative SMRAD 51 in irs 1 and irs1SF cells , defective for XRCC 2 and XRCC 3 , respectively , and in their corresponding wild type cells ( V 79 and AA 8 , respectively ) . ^^^ |
|
| Interacting proteins: Q06609 and P35568 |
Pubmed |
SVM Score :0.0 |
| XRCC 2 mutant irs 1 cells exhibit hypersensitivity to hydroxyurea ( HU ) and are defective in the induction of RAD 51 foci after HU treatment . ^^^ In addition , the HU induced chromatin association of RAD 51 is deficient in irs 1 mutant . ^^^ Interestingly , irs 1 cells are only slightly sensitive to thymidine and able to form intact RAD 51 foci in S phase cells arrested with thymidine . ^^^ Irs 1 cells showed increased level of chromatin bound RAD 51 as well as the wild type cells after thymidine treatment . ^^^ |
|
| Interacting proteins: Q06609 and P35568 |
Pubmed |
SVM Score :0.0 |
| T antigen of the human polyomavirus JC attenuates faithful DNA repair by forcing nuclear interaction between IRS 1 and Rad 51 . ^^^ Following T antigen mediated nuclear translocation , IRS 1 binds Rad 51 at the site of damaged DNA . ^^^ |
|
| Interacting proteins: Q06609 and P35568 |
Pubmed |
SVM Score :0.0 |
| In the presence of JCV T antigen , insulin receptor substrate 1 ( IRS 1 ) translocated to the nucleus where it co localized with Rad 51 , possibly attenuating HRR . . ^^^ IRS 1 Rad 51 nuclear interaction sensitizes JCV T antigen positive medulloblastoma cells to genotoxic treatment . ^^^ |
|
| Interacting proteins: Q06609 and P35568 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06609 and P35568 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06609 and P35568 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06609 and P35568 |
Pubmed |
SVM Score :0.0 |
| NA |
|