| Interacting proteins: P18074 and Q06609 |
Pubmed |
SVM Score :0.0 |
| However , a number of mammalian DNA repair proteins lack NLS clusters ; these proteins include ERCC 1 , ERCC 2 ( XPD ) , mouse RAD 51 , and the HHR23B / p58 and HHR23A subunits of XPC . ^^^ |
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| Interacting proteins: P18074 and Q06609 |
Pubmed |
SVM Score :0.0 |
| This lack of correlation may be due to the contribution of XPD to other functions including interactions with the Rad 51 repair pathway . . ^^^ |
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| Interacting proteins: P18074 and Q06609 |
Pubmed |
SVM Score :0.0 |
| In contrast , in SK MG 4 cells treated with cisplatin , XPD overexpression leads to increased Rad 51 related homologous recombinational repair , increased sister chromatid exchanges , and accelerated interstrand cross link removal . ^^^ Moreover , we present biochemical evidence of an XPD Rad 51 protein interaction , which is modulated by DNA damage . ^^^ To our knowledge , this is the first description of functional cross talk between XPD and Rad 51 , which leads to bifunctional alkylating agent drug resistance and accelerated removal of interstrand cross links . . ^^^ |
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| Interacting proteins: P18074 and Q06609 |
Pubmed |
SVM Score :0.0 |
| Polymorphisms have been identified in several DNA repair genes , such as XRCC 1 , XPD , XRCC 3 , and RAD 51 , but the influence of specific genetic variants on repair phenotype and cancer risk has not yet been clarified . ^^^ The PCR RFLP method was used to analyze the XRCC 1 Arg399Gln , XPD Lys751Gln , XRCC 3 Thr241Met , and RAD 51 G135C polymorphisms . ^^^ |
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| Interacting proteins: P18074 and Q06609 |
Pubmed |
SVM Score :0.0 |
| The same trends were observable under conditions of post irradiation incubation in EM 9 medium , more efficiently in recA strain than in the wild type strain . ( 2 ) The addition of these drugs gave an apparent enhancement of the frequency of UV induced mutation to arginine prototrophy , corresponding to a decrease in survival . ( 3 ) There were negligible effects of the drugs on survival and mutation in the excision repair defective strain , Hs 30 ( uvrB ) . ( 4 ) The removal of thymine dimers from DNA was actually reduced by the addition of procaine . ^^^ |
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| Interacting proteins: P18074 and Q06609 |
Pubmed |
SVM Score :0.0 |
| An SSB repair defective cell line , EM 9 with an XRCC 1 mutation , has an increased number of spontaneous gammaH2Ax and RAD 51 foci , suggesting that endogenous SSBs collapse replication forks , triggering recombination repair . ^^^ Furthermore , we show that gammaH2Ax , DSBs , and RAD 51 foci are synergistically induced in EM 9 cells with camptothecin , suggesting that lack of SSB repair in EM 9 causes more collapsed forks and more recombination repair . ^^^ |
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| Interacting proteins: P18074 and Q06609 |
Pubmed |
SVM Score :0.0 |
| We analyzed 49 SNPs in BRCA 1 , BRCA 2 , ESR 1 , XRCC 1 , XRCC 2 , XRCC 3 , NBN , RAD 51 , RAD 52 , LIG 4 , ATM , BCL 2 , TGFB 1 , MSH 6 , ERCC 2 , XPF , NR3C1 , CYP1A1 , CYP2C9 , CYP2C19 , CYP3A5 , CYP2D6 , CYP11B2 , and CYP17A1 genes using the Pyrosequencing technique . ^^^ |
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