| Interacting proteins: Q06609 and P16104 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06609 and P16104 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06609 and P16104 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06609 and P16104 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06609 and P16104 |
Pubmed |
SVM Score :0.0 |
| BRCA 1 , Rad 51 , and CHK 2 contribute to recombinational repair , in part independently of H2AX . ^^^ |
|
| Interacting proteins: Q06609 and P16104 |
Pubmed |
SVM Score :0.0 |
| Using two different methods to create DNA double strand breaks in human cells , we found that the repair factors Rad 50 and Rad 51 each colocalized with phosphorylated H2AX ( gamma H2AX ) foci after DNA damage . ^^^ The product of the tumor suppressor gene BRCA 1 also colocalized with gamma H2AX and was recruited to these sites before Rad 50 or Rad 51 . ^^^ CONCLUSIONS : The pattern of gamma H2AX foci that is established within a few minutes of DNA damage accounts for the patterns of Rad 50 , Rad 51 , and Brca 1 foci seen much later during recovery from damage . ^^^ |
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| Interacting proteins: Q06609 and P16104 |
Pubmed |
SVM Score :0.0 |
| These abnormalities are not associated with a failure of the BLM T99A / T122A protein to localize to replication foci or to colocalize either with ATR itself or with other proteins that are required for response to DNA damage , such as phosphorylated histone H2AX and RAD 51 . ^^^ |
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| Interacting proteins: Q06609 and P16104 |
Pubmed |
SVM Score :0.0 |
| To analyse this subject in grasshoppers , organisms that have been considered as models for meiotic studies for many years , we have studied the localization of phosphorylated histone H2AX ( gamma H2AX ) , which marks the sites of double strand breaks ( DSBs ) , in combination with localization of cohesin SMC 3 and recombinase Rad 51 . ^^^ |
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| Interacting proteins: Q06609 and P16104 |
Pubmed |
SVM Score :0.0 |
| We previously hypothesized that Mei 1 is likely required for the formation of genetically programmed double strand breaks ( DSBs ) , the initiating event of meiotic recombination because in mutant spermatocytes ( 1 ) RAD 51 foci are greatly reduced at zygonema ; ( 2 ) RAD 51 foci can be restored by cisplatin induced DNA damage ; and ( 3 ) phosphorylated H2AX is greatly reduced at leptonema . ^^^ |
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| Interacting proteins: Q06609 and P16104 |
Pubmed |
SVM Score :0.0 |
| We have studied by means of immunofluorescence the localisation of the phosphorylated histone H2AX ( gamma H2AX ) , which marks the sites of double strand breaks ; the SMC 3 cohesin subunit , which is thought to have a close relationship to the development of the axial element ( a synaptonemal complex component ) ; and the recombinase RAD 51 . ^^^ We observed a marked nuclear polarization of both the maturation of SMC 3 cohesin axis and the ulterior appearance of gamma H2AX and RAD 51 foci , these being exclusively restricted to those chromosomal regions that first form cohesin axis stretches . ^^^ |
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| Interacting proteins: Q06609 and P16104 |
Pubmed |
SVM Score :0.0 |
| Overexpression of oncogenes leads to the formation of phosphorylated H2AX foci , induction of Rad 51 protein levels and ATM / ATR dependent phosphorylation of p 53 . ^^^ |
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