| Interacting proteins: Q06455 and Q05516 |
Pubmed |
SVM Score :0.0 |
| We found that ETO is one of the corepressors recruited by PLZF . ^^^ The PLZF and ETO proteins associate in vivo and in vitro , and ETO can potentiate transcriptional repression by PLZF . ^^^ The N terminal portion of ETO forms complexes with PLZF , while the C terminal region , which was shown to bind to N CoR and SMRT , is required for the ability of ETO to augment transcriptional repression by PLZF . ^^^ The second repression domain ( RD 2 ) of PLZF , not the POZ / BTB domain , is necessary to bind to ETO . ^^^ The ETO protein disrupted in t ( 8 ; 21 ) associated acute myeloid leukemia is a corepressor for the promyelocytic leukemia zinc finger protein . ^^^ |
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| Interacting proteins: Q06455 and Q05516 |
Pubmed |
SVM Score :0.0 |
| ETO is a corepressor for PLZF and potentiates transcriptional repression by linking PLZF to a histone deacetylase containing complex . ^^^ In transiently transfected cells and in a cell line derived from a patient with t ( 8 ; 21 ) leukemia , PLZF and AML 1 / ETO formed a tight complex . ^^^ In transient assays , AML 1 / ETO blocked transcriptional repression by PLZF , even at substoichiometric levels relative to PLZF . ^^^ This effect was dependent on the presence of the ETO zinc finger domain , which recruits corepressors , and could not be rescued by overexpression of co repressors that normally enhance PLZF repression . ^^^ AML 1 / ETO also excluded PLZF from the nuclear matrix and reduced its ability to bind to its cognate DNA binding site . ^^^ |
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| Interacting proteins: Q06455 and Q05516 |
Pubmed |
SVM Score :0.0 |
| The ETO protein of t ( 8 ; 21 ) acute myeloid leukemia ( AML ) is an excellent candidate as a common factor because it is normally expressed in human hematopoietic cells , it binds to histone deacetylases ( HDACs ) , and it interacts with the PLZF protein of t ( 11 ; 17 ) acute promyelocytic leukemia . ^^^ |
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