| Interacting proteins: Q06455 and P41182 |
Pubmed |
SVM Score :0.0 |
| ETO protein of t ( 8 ; 21 ) AML is a corepressor for Bcl 6 B cell lymphoma oncoprotein . ^^^ To determine whether ETO functionally links a broader range of disease entities , we asked whether ETO forms a complex with the Bcl 6 oncoprotein of B cell lymphomas . ^^^ We found that ETO and Bcl 6 are coexpressed in normal and malignant lymphoid tissue , where they interact and colocalize in nuclear speckles . ^^^ ETO binds to the fourth zinc finger of Bcl 6 , enhances Bcl 6 repression of artificial and endogenous genes in an HDAC dependent manner , and forms a complex with Bcl 6 on the promoters of its endogenous target genes in B cell lymphoma cells . ^^^ |
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| Interacting proteins: Q06455 and P41182 |
Pubmed |
SVM Score :0.0 |
| ETO has also been found to act as a co repressor of the promyelocytic zinc finger and Bcl 6 oncoproteins , suggesting that it may play a common role as a transcriptional co repressor leading to human disease . ^^^ |
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