| Interacting proteins: O43439 and Q06455 |
Pubmed |
SVM Score :1.0838808 |
| Similarly , the chimeric oncoprotein AML 1 ETO interacted with both MTGR 1 and MTG 16 . 1.0838808^^^ |
|
| Interacting proteins: O43439 and Q06455 |
Pubmed |
SVM Score :0.0 |
| We previously showed that ectopically expressed AML 1 MTG8 fusion protein is associated with an MTG 8 like protein in the mouse myeloid precursor cell line L G , and this association seemed to be required for AML 1 MTG8 to stimulate proliferation . ^^^ As a candidate cDNA for this MTG 8 like protein , a 6 . 4 kb MTGR 1 cDNA encoding human MTGR1b protein of 604 amino acids was isolated . ^^^ |
|
| Interacting proteins: O43439 and Q06455 |
Pubmed |
SVM Score :0.0 |
| We characterize two human MTG 8 related genes , MTGR 1 and MTGR 2 ( HGMW approved symbols CBFA2T2 and CBFA2T3 ) . ^^^ |
|
| Interacting proteins: O43439 and Q06455 |
Pubmed |
SVM Score :0.0 |
| In contrast , there was a weak interaction of ZNF 652 with CBFA2T1 and CBFA2T2 , the other two members of this ETO family . ^^^ The transcriptional repression of growth factor independent 1 ( GFI 1 ) , a previously characterized ETO effector zinc finger protein , was shown to be enhanced by CBFA2T1 , but to a lesser extent by CBFA2T2 and CBFA2T3 . ^^^ |
|
| Interacting proteins: O43439 and Q06455 |
Pubmed |
SVM Score :0.0 |
| The AML 1 MTG8 leukemic fusion protein forms a complex with a novel member of the MTG 8 ( ETO / CDR ) family , MTGR 1 . ^^^ Molecular cloning of cDNA indicated that the AML 1 MTG8 binding protein ( MTGR 1 ) is highly related to MTG 8 and similar to Drosophila Nervy . ^^^ Comparison of amino acid sequences among MTGR 1 , MTG 8 , and Nervy revealed four evolutionarily conserved regions ( NHR 1 to NHR 4 ) . ^^^ |
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| Interacting proteins: O43439 and Q06455 |
Pubmed |
SVM Score :0.0 |
| The structural analysis of the cDNAs showed that AML 1 was fused to a novel gene named MTG 16 ( Myeloid Translocation Gene on chromosome 16 ) which shows high homology to MTG 8 ( ETO / CDR ) and MTGR 1 . ^^^ |
|
| Interacting proteins: O43439 and Q06455 |
Pubmed |
SVM Score :0.0 |
| The Eight twenty one ( ETO ) homologues are nuclear repressor proteins including ETO , myeloid transforming gene related protein 1 ( MTGR 1 ) , and myeloid transforming gene chromosome 16 ( MTG 16 ) . ^^^ Our results showed MTGR 1 and MTG 16 to be ubiquitously expressed in leukemic cell lines , whereas expression of ETO was observed only in an erythroleukemic cell line . ^^^ |
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| Interacting proteins: O43439 and Q06455 |
Pubmed |
SVM Score :0.0 |
| The Nervy homology 2 ( NHR 2 ) domain in ETO mediates oligomerization and AML1 / ETO ' s interactions with ETO , MTGR 1 , and MTG 16 , and with the corepressor molecules mSin3A and HDAC 1 and HDAC 3 . ^^^ Oligomerization is also required for AML1 / ETO ' s interactions with ETO , MTGR 1 , and MTG 16 , but not with other corepressor molecules . . ^^^ |
|
| Interacting proteins: O43439 and Q06455 |
Pubmed |
SVM Score :0.0 |
| NA |
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