| Interacting proteins: Q99856 and Q06187 |
Pubmed |
SVM Score :0.61497076 |
| Bright was not appreciably phosphorylated by Btk ; however , a third tyrosine phosphorylated protein coprecipitated with Bright . 0.61497076^^^ |
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| Interacting proteins: Q99856 and Q06187 |
Pubmed |
SVM Score :0.0 |
| A correlation of the base composition of the satellite DNAs contained in the heterochromatin of the species studied with the relative fluorescence and decondensation patterns showed that : 1 ) the extremely fluorochrome bright areas and those decondensed are present only in species containing AT rich satellite DNA ; 2 ) the opposite is not true since some AT rich satellite DNAs are neither fluorochrome bright nor decondensed ; 3 ) there is no good correspondence between Hoechst bright areas and the decondensed ones . ^^^ AT richness therefore appears to be a necessary but not sufficient condition both for bright fluorescence and decondensation . ^^^ |
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| Interacting proteins: Q99856 and Q06187 |
Pubmed |
SVM Score :0.0 |
| We now report that Bright coprecipitates with Bruton ' s tyrosine kinase ( Btk ) , the defective enzyme in 10 linked immunodeficiency disease ( xid ) . ^^^ Furthermore , we observed Btk in the nucleus of activated murine B cells , and mobility shift assays suggest that it is a component of the Bright DNA binding complex . ^^^ While BRIGHT protein was synthesized in activated spleen cells from xid mice , it did not bind DNA or associate stably with Btk . ^^^ |
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| Interacting proteins: Q99856 and Q06187 |
Pubmed |
SVM Score :0.0 |
| In the mouse , Bright expression is tightly regulated and B cell restricted and the Bright protein associates with Bruton ' s tyrosine kinase ( Btk ) , the defective enzyme in 10 linked immunodeficiency . ^^^ Because so little is known about human Bright , we sought to determine where human Bright is expressed in normal B cell differentiation and whether it also forms complexes with Btk . ^^^ However , the human protein bound prototypic Bright DNA binding motifs and , like mouse Bright , was capable of associating with Btk . ^^^ |
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| Interacting proteins: Q99856 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Recent publications from our lab indicated that functional , but not kinase inactive , Bruton ' s tyrosine kinase ( Btk ) is critical for Bright activity in an in vitro model system , yet Bright itself is not appreciably tyrosine phosphorylated . ^^^ These data suggested that a third protein , and Btk substrate , must contribute to Bright enhanced immunoglobulin transcription . ^^^ These data suggest that Bright functions as a three component protein complex in the immunoglobulin locus and tie together previous data indicating important roles for Btk and TFII 1 in B lymphocytes . . ^^^ |
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| Interacting proteins: Q99856 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
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