| Interacting proteins: Q08881 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q08881 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Sequence analysis indicates that txk contains SH 2 , SH 3 and kinase catalytic domains and belongs to the tec family of cytoplasmic protein tyrosine kinases which includes tec , itk and btk . ^^^ |
|
| Interacting proteins: Q08881 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Btk and two related proteins , Itk and Tec , are members of a distinct family of tyrosine kinases . ^^^ |
|
| Interacting proteins: Q08881 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Because mutations in Btk and the corresponding human gene are associated with 10 linked immunodeficiency syndromes , it was of interest to map Itk and its human counterpart . ^^^ |
|
| Interacting proteins: Q08881 and Q06187 |
Pubmed |
SVM Score :0.0 |
| The sequence of rlk showed that it is most closely related to the subfamily of cytoplasmic tyrosine kinases that includes the Btk , Itk , and Tec proteins . ^^^ |
|
| Interacting proteins: Q08881 and Q06187 |
Pubmed |
SVM Score :0.0 |
| BMX , a novel nonreceptor tyrosine kinase gene of the BTK / ITK / TEC / TXK family located in chromosome Xp22 . 2 . ^^^ Bmx cDNA comprises a long open reading frame of 675 amino acids , containing one SH 3 , one SH 2 and one tyrosine kinase domain , which are about 70 % identical with Btk , Itk and Tec and somewhat less with Txk tyrosine kinase sequences . ^^^ |
|
| Interacting proteins: Q08881 and Q06187 |
Pubmed |
SVM Score :0.0 |
| This observation is consistent with the classification of Btk together with the recently characterized kinases , Tec and Itk , into a separate sub family of cytoplasmic PTKs . ^^^ |
|
| Interacting proteins: Q08881 and Q06187 |
Pubmed |
SVM Score :0.0 |
| An analogous site with the same specificity is also present in Itk , the T cell specific homologue of Btk . ^^^ |
|
| Interacting proteins: Q08881 and Q06187 |
Pubmed |
SVM Score :0.0 |
| PH domains were then found at the N termini of the tecA homologues Btk and itk . ^^^ |
|
| Interacting proteins: Q08881 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Itk is a T cell protein tyrosine kinase ( PTK ) that , along with Btk and Tec , belongs to a family of cytoplasmic PTKs with N terminal pleckstrin homology domains . ^^^ |
|
| Interacting proteins: Q08881 and Q06187 |
Pubmed |
SVM Score :0.0 |
| The tyrosine kinase Itk / Tsk is a T cell specific analog of Btk , the tyrosine kinase defective in the human immunodeficiency 10 linked agammaglobulinemia and in xid mice . ^^^ |
|
| Interacting proteins: Q08881 and Q06187 |
Pubmed |
SVM Score :0.0 |
| The Tec family of cytoplasmic tyrosine kinases , which include Btk ( the 10 linked agammaglobulinemia gene ) , Itk , and Tec , is thought to be involved in lymphoid cell signaling pathways . ^^^ In this work , we show binding of WASP to the Src homology 3 domains of Btk , Itk , Tec , Grb 2 , and phospholipase C gamma , which suggests a function for WASP in lymphoid cell signaling . . ^^^ |
|
| Interacting proteins: Q08881 and Q06187 |
Pubmed |
SVM Score :0.0 |
| We recently demonstrated that the PH domains of Tec family protein tyrosine kinases Btk and Emt ( equal to Itk and Tsk ) interact with protein kinase C ( PKC ) and that PKC down regulates Btk by phosphorylation . ^^^ |
|
| Interacting proteins: Q08881 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Btk along with Tec , Itk and Bmx belong to a distinct family of protein kinases . ^^^ |
|
| Interacting proteins: Q08881 and Q06187 |
Pubmed |
SVM Score :0.0 |
| The tyrosine kinase Tec belongs to a new group of structurally related nonreceptor tyrosine kinases that also includes Btk and Itk . ^^^ |
|
| Interacting proteins: Q08881 and Q06187 |
Pubmed |
SVM Score :0.0 |
| For all three SH 3 domains maximum stability was observed in the pH region 4 . 5 < pH < 7 . 0 where these domains unfold at temperatures of 353K ( Btk ) , 342K ( Itk ) , and 344K ( Tec ) . ^^^ At these temperatures an enthalpy change of 196 kJ / mol , 178 kJ / mol , and 169 kJ / mol was measured for Btk , Itk , and Tec SH 3 domains , respectively . ^^^ |
|
| Interacting proteins: Q08881 and Q06187 |
Pubmed |
SVM Score :0.0 |
| The Tec protein tyrosine kinase family includes Btk , Itk / Tsk / Emt , Tec , Rlk / Txk , and Bmx which are involved in signals mediated by various cytokines or antigen receptors . ^^^ |
|
| Interacting proteins: Q08881 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Btk is a member of the Tec family of nonreceptor protein tyrosine kinases that includes Bmx , Itk , Tec , and Txk . ^^^ Itk and Tec have recently been shown to reconstitute PLCgamma 2 dependent signaling in Btk deficient human cells , but it is not known whether the atypical Tec family members , Bmx and Txk , can reconstitute function . ^^^ |
|
| Interacting proteins: Q08881 and Q06187 |
Pubmed |
SVM Score :0.0 |
| The Tec protein tyrosine kinase ( PTK ) family includes Btk , Itk / Tsk / Emt , Tec , Rlk / Txk and Bmx , which are involved in signals mediated by various surface receptors . ^^^ |
|
| Interacting proteins: Q08881 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Tec , Btk , Itk , Bmx , and Txk constitute the Tec family of protein tyrosine kinases ( PTKs ) , a family with the distinct feature of containing a pleckstrin homology ( PH ) domain . ^^^ |
|
| Interacting proteins: Q08881 and Q06187 |
Pubmed |
SVM Score :0.0 |
| The structures for the PH domains of Bmx , Itk , and Tec were modelled based on Btk structure . ^^^ |
|
| Interacting proteins: Q08881 and Q06187 |
Pubmed |
SVM Score :0.0 |
| This process requires expression of SLP adaptors and involves phosphorylation of phospholipase C gamma isoforms by the Tec related protein tyrosine kinase Btk in B cells and Itk in T cells . ^^^ The SH 2 domain of Btk and Itk is essential for phospholipase C gamma phosphorylation and mutations in this domain lead to the 10 linked agammaglobulinemia immuno deficiency in humans . ^^^ Here we show that , in contrast to SH 2 domains from other signaling proteins , the Btk and Itk SH 2 domains exhibit a restricted binding specificity . ^^^ Our findings suggest that Btk / Itk and phospholipase C gamma both bind via their SH 2 domain to phosphorylated SLP adaptors , and that this association is required for the activation of phospholipase C gamma . . ^^^ |
|
| Interacting proteins: Q08881 and Q06187 |
Pubmed |
SVM Score :0.0 |
| The Tec protein kinase family includes Btk , Itk , Tec , Rlk and Bmx , which are critically involved in signals mediated by various cytokines and antigen receptors . ^^^ |
|
| Interacting proteins: Q08881 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Btk along with Tec , Itk , Bmx and Txk belong to a distinct family of protein kinases . ^^^ |
|
| Interacting proteins: Q08881 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Three major classes of signalling molecule are regulated by binding of D 3 phosphoinositides to PH domains : guanine nucleotide exchange proteins for Rho family GTPases , the TEC family tyrosine kinases such as BTK and ITK in B and T lymphocytes , respectively , and the AGC superfamily of serine / threonine protein kinases . ^^^ |
|
| Interacting proteins: Q08881 and Q06187 |
Pubmed |
SVM Score :0.0 |
| The Tec family of cytoplasmic tyrosine kinases : mammalian Btk , Bmx , Itk , Tec , Txk and homologs in other species . ^^^ |
|
| Interacting proteins: Q08881 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Tec is the prototypic member of a family of intracellular tyrosine kinases that includes Txk , Bmx , Itk , and Btk . ^^^ |
|
| Interacting proteins: Q08881 and Q06187 |
Pubmed |
SVM Score :0.0 |
| This observation provides an explanation to why the TH region of Btk makes intermolecular interactions , whereas the corresponding interaction in the related Itk kinase with only one PRR , is intramolecular . . ^^^ |
|
| Interacting proteins: Q08881 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Tec family tyrosine kinases , Bruton ' s tyrosine kinase ( Btk ) , Itk , Bmx , Tec , and Txk , are multi domain proteins involved in hematopoietic signaling . ^^^ |
|
| Interacting proteins: Q08881 and Q06187 |
Pubmed |
SVM Score :0.0 |
| The major phosphorylation sites were identified as conserved tyrosines , for Itk Y 180 and for Bmx Y 215 , both sites being homologous to the Y 223 site in Btk . ^^^ |
|
| Interacting proteins: Q08881 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Btk is essential for B cell receptor signaling , because mutations in Btk are responsible for 10 linked agammaglobulinemia ( XLA ) in humans and 10 linked immunodeficiency ( xid ) in mice , whereas Itk is involved in T cell receptor signaling . ^^^ Expression and function of Tec , Itk , and Btk in lymphocytes : evidence for a unique role for Tec . ^^^ The Tec protein tyrosine kinase is the founding member of a family that includes Btk , Itk , Bmx , and Txk . ^^^ Btk is essential for B cell receptor signaling , because mutations in Btk are responsible for 10 linked agammaglobulinemia ( XLA ) in humans and 10 linked immunodeficiency ( xid ) in mice , whereas Itk is involved in T cell receptor signaling . ^^^ In this study , we show that Tec protein is expressed at substantially lower levels in primary T and B cells relative to Itk and Btk , respectively . ^^^ |
|
| Interacting proteins: Q08881 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Lyn , Lck , Syk , ZAP 70 , Fyn , Btk , Itk ) is the earliest detectable signaling response upon antigen induced immunoreceptor activation in inflammatory cells . ^^^ |
|
| Interacting proteins: Q08881 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Members of the Tec kinase family ( Bmx , Btk , Itk , Rlk and Tec ) are primarily expressed in the hematopoietic system and form , after the Src kinase family , the second largest class of non receptor protein tyrosine kinases . ^^^ |
|
| Interacting proteins: Q08881 and Q06187 |
Pubmed |
SVM Score :0.0 |
| The Tec family of protein tyrosine kinases ( PTKs ) , that includes Tec , Itk , Btk , Bmx , and Txk , plays an essential role in phospholipase Cgamma ( PLCgamma ) activation following antigen receptor stimulation . ^^^ |
|
| Interacting proteins: Q08881 and Q06187 |
Pubmed |
SVM Score :0.0 |
| We have compared acute and late phase allergic airway reactions in mice lacking either Btk or interleukin 2 inducible T cell kinase ( Itk ) , another Tec kinase expressed in mast cells . ^^^ |
|
| Interacting proteins: Q08881 and Q06187 |
Pubmed |
SVM Score :0.0 |
| With this technique , we showed that , in live T cells , the Tec vesicles are located at the plasma membrane , the vesicles are unique to Tec ( and not the related kinase Itk ) , and their formation and maintenance require T cell receptor signaling through Src family kinases and PI 3 kinase . ^^^ |
|
| Interacting proteins: Q08881 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Lyn , Lck , Syk , ZAP 70 , Btk , Itk and JAK ) is the earliest detectable signaling response upon activation of immune receptors ( T cell receptor , B cell receptor and FCepsilonR 1 ) , cytokine receptors and chemokine receptors in inflammatory cells . ^^^ |
|
| Interacting proteins: Q08881 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Since PI3K can affect activation of Btk , which in turn potentiates calcium fluxes , during B cell development , our results suggest that PI3K could play a role in the regulation of Itk kinases in T cells , and that both cell types share a common signaling network to modulate calcium responses downstream of their antigen receptor . . ^^^ |
|
| Interacting proteins: Q08881 and Q06187 |
Pubmed |
SVM Score :0.0 |
| The complete nucleotide sequence of the cDNA indicates that it is related most closely to EMT , a tyrosine kinase of T cells and to the B cell tyrosine kinase Btk , which is mutated in 10 linked agammaglobulinemia ( XLA ) in humans and 10 linked immunodeficiency disease ( XID ) in mouse . ^^^ TXK shares 60 % amino acid homology with EMT and 57 % with BTK over the SH 3 , SH 2 ( Src homology ) and catalytic domains but unlike BTK , EMT and tec , it lacks Gap 1 homology and steroid hormone receptor homology in the N terminal region . ^^^ |
|
| Interacting proteins: Q08881 and Q06187 |
Pubmed |
SVM Score :0.0 |
| EMT is related to the B cell progenitor kinase ( BPK ) , which has recently been implicated in 10 linked hypogammaglobulinemia , to the TECI mammalian kinase , which has been implicated in liver neoplasia , to the more widely expressed TECII mammalian kinase , and to the Drosophila melanogaster Dsrc 28 kinase . ^^^ Taken together , it seems that EMT is a member of a new family of intracellular kinases that includes BPK , TECI , and TECII . ^^^ |
|
| Interacting proteins: Q08881 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Stimulation of surface CD 28 molecules on mast cells with anti CD 28 mAbs induced tyrosine phosphorylation of cellular proteins , including several protein tyrosine kinases and their substrates , such as Itk / Emt ( Emt ) , Btk , Syk , c Cbl , Shc , and Vav . ^^^ |
|
| Interacting proteins: Q08881 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Two of them , Btk and Emt , are tyrosine phosphorylated and enzymatically activated upon cross linking of the high affinity IgE receptor ( Fc epsilonRI ) , suggesting their involvement in mast cell activation . ^^^ |
|
| Interacting proteins: Q08881 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Retroviral transfer of Emt ( = Itk / Tsk ) , Btk ' s closest relative , also partially improved the ability of btk mutant mast cells to secrete mediators . ^^^ |
|
| Interacting proteins: Q08881 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q08881 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q08881 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q08881 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q08881 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q08881 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q08881 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q08881 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q08881 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q08881 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q08881 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|