| Interacting proteins: P58753 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Furthermore , co immunoprecipitation experiments revealed that Btk can also interact with key proteins involved in TLR 4 signal transduction , namely , MyD 88 , Mal ( MyD 88 adapter like protein ) , and interleukin 1 receptor associated kinase 1 , but not TRAF 6 . ^^^ The ability of Btk to interact with TLR 4 and Mal suggests a role for Btk in lipopolysaccharide ( LPS ) signal transduction . ^^^ |
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| Interacting proteins: P58753 and Q06187 |
Pubmed |
SVM Score :0.0 |
| We demonstrate here that after TLR 2 and TLR 4 stimulation Mal becomes phosphorylated by Bruton ' s tyrosine kinase ( Btk ) and then interacts with SOCS 1 , which results in Mal polyubiquitination and subsequent degradation . ^^^ |
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| Interacting proteins: P58753 and Q06187 |
Pubmed |
SVM Score :0.0 |
| We found that the Bruton ' s tyrosine kinase ( Btk ) inhibitor LFM A 13 could block the endogenous phosphorylation of Mal on tyrosine in cells treated with macrophage activating lipopeptide 2 or LPS . ^^^ Furthermore , Btk immunoprecipitated from THP 1 cells activated by LPS could phosphorylate Mal . ^^^ Our study therefore provides the first demonstration of the key role of Mal phosphorylation on tyrosine during signaling by TLR 2 and TLR 4 and identifies a novel function for Btk as the kinase involved . . ^^^ |
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| Interacting proteins: P58753 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P58753 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P58753 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P58753 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|