| Interacting proteins: P51813 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Etk / Bmx is the newest member of Btk tyrosine kinase family that contains a pleckstrin homology domain , an src homology 3 domain , an src homology 2 domain , and a catalytic domain . ^^^ Unlike other members of the Btk family kinases , which are mostly hemopoietic cell specific , Etk / Bmx is preferentially expressed in epithelial and endothelial cells . ^^^ |
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| Interacting proteins: P51813 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Etk , a Btk family tyrosine kinase , mediates cellular transformation by linking Src to STAT 3 activation . ^^^ Etk ( also called Bmx ) is a member of the Btk tyrosine kinase family and is expressed in a variety of hematopoietic , epithelial , and endothelial cells . ^^^ |
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| Interacting proteins: P51813 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Etk / Bmx is a member of the Btk / Tec family of kinases , which are characterized by having a pleckstrin homology domain at the N terminus , in addition to the Src homology 3 ( SH 3 ) , SH 2 , and the catalytic domains , shared with the Src family kinases . ^^^ Etk , or Btk kinases in general , has been implicated in the regulation of apoptosis . ^^^ |
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| Interacting proteins: P51813 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Etk / BMX , a member of the Btk family of tyrosine kinases , is highly expressed in cells with great migratory potential , including endothelial cells and metastatic carcinoma cell lines . ^^^ |
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| Interacting proteins: P51813 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Etk / Bmx is a member of the Btk family tyrosine kinase , which contains an N terminal pleckstrin homology domain . ^^^ |
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| Interacting proteins: P51813 and Q06187 |
Pubmed |
SVM Score :0.0 |
| BMX , a novel nonreceptor tyrosine kinase gene of the BTK / ITK / TEC / TXK family located in chromosome Xp22 . 2 . ^^^ Bmx cDNA comprises a long open reading frame of 675 amino acids , containing one SH 3 , one SH 2 and one tyrosine kinase domain , which are about 70 % identical with Btk , Itk and Tec and somewhat less with Txk tyrosine kinase sequences . ^^^ Interestingly , chromosome 10 also contains the closest relative of BMX , the BTK gene , implicated in 10 linked agammaglobulinemia . ^^^ |
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| Interacting proteins: P51813 and Q06187 |
Pubmed |
SVM Score :0.0 |
| The Tec family is a recently emerging subfamily among nonreceptor type protein tyrosine kinases ( PTKs ) consisting of Tec , Txk , Btk , Bmx , and Itk / Tsk / Emt . ^^^ |
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| Interacting proteins: P51813 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Btk and the other family members , Tec , ltk and Bmx , contain five regions , four of which are common structural and functional modules that are found in other signaling proteins . ^^^ |
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| Interacting proteins: P51813 and Q06187 |
Pubmed |
SVM Score :0.0 |
| The molecules discussed include Src family kinases , Syk , Grb 2 adaptor protein , and Tec family kinases Bmx and Btk . ^^^ |
|
| Interacting proteins: P51813 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Btk along with Tec , Itk and Bmx belong to a distinct family of protein kinases . ^^^ |
|
| Interacting proteins: P51813 and Q06187 |
Pubmed |
SVM Score :0.0 |
| The Tec protein tyrosine kinase family includes Btk , Itk / Tsk / Emt , Tec , Rlk / Txk , and Bmx which are involved in signals mediated by various cytokines or antigen receptors . ^^^ |
|
| Interacting proteins: P51813 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Reconstitution of Btk signaling by the atypical tec family tyrosine kinases Bmx and Txk . ^^^ Btk is a member of the Tec family of nonreceptor protein tyrosine kinases that includes Bmx , Itk , Tec , and Txk . ^^^ Itk and Tec have recently been shown to reconstitute PLCgamma 2 dependent signaling in Btk deficient human cells , but it is not known whether the atypical Tec family members , Bmx and Txk , can reconstitute function . ^^^ Here we reconstitute Btk deficient DT 40 B cells with Bmx and Txk to compare their function with other Tec kinases . ^^^ |
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| Interacting proteins: P51813 and Q06187 |
Pubmed |
SVM Score :0.0 |
| The Tec protein tyrosine kinase ( PTK ) family includes Btk , Itk / Tsk / Emt , Tec , Rlk / Txk and Bmx , which are involved in signals mediated by various surface receptors . ^^^ |
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| Interacting proteins: P51813 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Tec , Btk , Itk , Bmx , and Txk constitute the Tec family of protein tyrosine kinases ( PTKs ) , a family with the distinct feature of containing a pleckstrin homology ( PH ) domain . ^^^ In 293 cells expressing recombinant BRDG 1 and various PTKs , Tec and Pyk 2 , but not Btk , Bmx , Lyn , Syk , or c Abl , induced marked phosphorylation of BRDG 1 on tyrosine residues . ^^^ |
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| Interacting proteins: P51813 and Q06187 |
Pubmed |
SVM Score :0.0 |
| The structures for the PH domains of Bmx , Itk , and Tec were modelled based on Btk structure . ^^^ |
|
| Interacting proteins: P51813 and Q06187 |
Pubmed |
SVM Score :0.0 |
| The Tec family has emerged recently as a subfamily among nonreceptor type protein tyrosine kinases , consisting of Tec , Btk , Itk / Tsk / Emt , Bmx , and Txk / Rlk . ^^^ |
|
| Interacting proteins: P51813 and Q06187 |
Pubmed |
SVM Score :0.0 |
| The Tec protein kinase family includes Btk , Itk , Tec , Rlk and Bmx , which are critically involved in signals mediated by various cytokines and antigen receptors . ^^^ |
|
| Interacting proteins: P51813 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Btk along with Tec , Itk , Bmx and Txk belong to a distinct family of protein kinases . ^^^ |
|
| Interacting proteins: P51813 and Q06187 |
Pubmed |
SVM Score :0.0 |
| The Tec family of cytoplasmic tyrosine kinases : mammalian Btk , Bmx , Itk , Tec , Txk and homologs in other species . ^^^ |
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| Interacting proteins: P51813 and Q06187 |
Pubmed |
SVM Score :0.0 |
| In endothelial cells overexpressing wild type platelet derived growth factor beta ( PDGFbeta ) receptors , which express Bmx and Src as their major Btk ( Bruton ' s tyrosine kinase ) family and Src family tyrosine kinases , respectively , PDGF can stimulate PI3K dependent tyrosine phosphorylation of DAPP 1 . ^^^ Finally , in vitro we find lipid modified Src to be the most effective DAPP 1 tyrosine kinase ( versus Syk , Lyn , Btk , and Bmx ) ; phosphorylation of DAPP 1 but not Src autophosphorylation is stimulated approximately 10 fold by PtdIns ( 3 , 4 , 5 ) P ( 3 ) ( IC ( 50 ) = 150 nm ) and phosphatidylinositol 3 , 4 bisphosphate but not by their nonbiological diastereoisomers and depends on PH domain mediated binding of DAPP 1 to PtdIns ( 3 , 4 , 5 ) P ( 3 ) containing membranes . ^^^ |
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| Interacting proteins: P51813 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Tec is the prototypic member of a family of intracellular tyrosine kinases that includes Txk , Bmx , Itk , and Btk . ^^^ |
|
| Interacting proteins: P51813 and Q06187 |
Pubmed |
SVM Score :0.0 |
| The results obtained indicate firstly that several members of the Tec family of tyrosine kinases are expressed in human neutrophils , including Tec , Btk , and Bmx . ^^^ |
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| Interacting proteins: P51813 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Tec family tyrosine kinases , Bruton ' s tyrosine kinase ( Btk ) , Itk , Bmx , Tec , and Txk , are multi domain proteins involved in hematopoietic signaling . ^^^ |
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| Interacting proteins: P51813 and Q06187 |
Pubmed |
SVM Score :0.0 |
| The major phosphorylation sites were identified as conserved tyrosines , for Itk Y 180 and for Bmx Y 215 , both sites being homologous to the Y 223 site in Btk . ^^^ |
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| Interacting proteins: P51813 and Q06187 |
Pubmed |
SVM Score :0.0 |
| LFM A 13 also negatively affected the translocation of Rac 2 , RhoA , ADP ribosylation factor 1 , Tec , Bmx , and Btk induced by fMet Leu Phe . ^^^ |
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| Interacting proteins: P51813 and Q06187 |
Pubmed |
SVM Score :0.0 |
| The Tec protein tyrosine kinase is the founding member of a family that includes Btk , Itk , Bmx , and Txk . ^^^ In contrast , overexpression of Btk , Itk , or Bmx does not induce NFAT activation . ^^^ |
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| Interacting proteins: P51813 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Members of the Tec kinase family ( Bmx , Btk , Itk , Rlk and Tec ) are primarily expressed in the hematopoietic system and form , after the Src kinase family , the second largest class of non receptor protein tyrosine kinases . ^^^ |
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| Interacting proteins: P51813 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Similarly , the hagfish Btk like molecule was not Btk itself , but qualified as a pre duplicated form of Btk and Bmx in jawed vertebrates . ^^^ |
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| Interacting proteins: P51813 and Q06187 |
Pubmed |
SVM Score :0.0 |
| The Tec family of protein tyrosine kinases ( PTKs ) , that includes Tec , Itk , Btk , Bmx , and Txk , plays an essential role in phospholipase Cgamma ( PLCgamma ) activation following antigen receptor stimulation . ^^^ |
|
| Interacting proteins: P51813 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Proteomics approaches permitted the identification of tyrosine kinases from three families : Src ( Lyn ) , Csk , and Tec ( Bmx , Btk ) . ^^^ |
|
| Interacting proteins: P51813 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51813 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51813 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51813 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51813 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
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