| Interacting proteins: P42768 and Q06187 |
Pubmed |
SVM Score :0.88780599 |
| An in vivo reconstitution system demonstrated that WASP is physically associated with Btk and can serve as the substrate for Btk . 0.88780599^^^ |
|
| Interacting proteins: P42768 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Tyrosine phosphorylation of the Wiskott Aldrich syndrome protein by Lyn and Btk is regulated by CDC 42 . ^^^ |
|
| Interacting proteins: P42768 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Previous work using Btk derived fusion proteins has shown that the Btk SH 3 domain binds to c Cbl and Wiskott Aldrich syndrome protein ( WASP ) in vitro . ^^^ |
|
| Interacting proteins: P42768 and Q06187 |
Pubmed |
SVM Score :0.0 |
| In XLA platelets , collagen treatment increased tyrosine phosphorylation of Tec and several other signaling proteins , including Lyn , Fyb , Slp 76 , and the Wiskott Aldrich syndrome protein . ^^^ |
|
| Interacting proteins: P42768 and Q06187 |
Pubmed |
SVM Score :0.0 |
| The proteolytic products of the Wiskott Aldrich syndrome protein ( WASP ) , a calpain and Btk substrate , and the 27 kDa degradation product of Btk did not redistribute to the Triton insoluble cytoskeleton in thrombin aggregated platelets , in contrast to the uncleaved proteins . ^^^ |
|
| Interacting proteins: P42768 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Fibrinogen binding to alpha ( IIb ) beta 3 stimulated the association of PKCtheta with tyrosine kinases Btk and Syk , and tyrosine phosphorylation of PKCtheta , Btk and the actin regulator , Wiskott Aldrich syndrome protein ( WASP ) . ^^^ |
|
| Interacting proteins: P42768 and Q06187 |
Pubmed |
SVM Score :0.0 |
| In this work , we show binding of WASP to the Src homology 3 domains of Btk , Itk , Tec , Grb 2 , and phospholipase C gamma , which suggests a function for WASP in lymphoid cell signaling . . ^^^ |
|
| Interacting proteins: P42768 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Evidence for AT transversion bias in wasp ( Hymenoptera : Symphyta ) mitochondrial genes and its implications for the origin of parasitism . ^^^ |
|
| Interacting proteins: P42768 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Tyrosine phosphorylation of WASp was blocked by Src family kinase inhibitors and reduced by treatment with wortmannin and in patients with 10 linked agammaglobulinemia ( XLA ) , a condition caused by a lack of functional expression of Btk . ^^^ This indicates that Src kinases , phosphatidylinositol 3 kinase ( PI 3 kinase ) , and Btk all contribute to the regulation of tyrosine phosphorylation of WASp . ^^^ |
|
| Interacting proteins: P42768 and Q06187 |
Pubmed |
SVM Score :0.0 |
| The DlEPV is introduced into the tephritid fruit fly larval host along with the wasp egg at oviposition . ^^^ |
|
| Interacting proteins: P42768 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Here we show that loss of IMD 2 , but not IMD 1 , IMD 3 , or IMD 4 , conferred upon yeast the same drug sensitivity found in elongation mutants . ^^^ |
|
| Interacting proteins: P42768 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Extrachromosomal copies of IMD 1 , IMD 3 , or IMD 4 could not rescue the drug sensitive phenotype of IMD 2 deletants . ^^^ IMD 1 is transcriptionally silent and bears critical amino acid substitutions compared with IMD 2 that destroy its function , offering strong evidence that it is a pseudogene . ^^^ |
|
| Interacting proteins: P42768 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Plasma levels of heparin cofactor 2 ( HCII ) , thrombin HCII complex ( THC ) , antithrombin ( AT ) , and thrombin AT complex ( TAT ) were evaluated in patients with disseminated intravascular coagulation ( DIC ) associated with several underlying diseases . ^^^ |
|
| Interacting proteins: P42768 and Q06187 |
Pubmed |
SVM Score :0.0 |
| WHILE METHADONE MAINTENANCE WAS CONTINUED IN THE ACCUSTOMED DOSAGE , POSTOPERATIVE ANALGESIA WAS ACCOMPLISHED SATISFACTORILY WITH 5O TO 100 MG DOSES OF MEPERIDINE AT 3 HOUR INTERVALS , AS REQUIRED . . ^^^ |
|
| Interacting proteins: P42768 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Specific activity of this enzyme was 58 . 8 mumol of L citrulline formed per min per mg of protein at 37 degrees . ^^^ The optimum pH of the purified enzyme was 6 . 0 and maximal activity was obtained at 50 degrees . ^^^ The spectrum of the pure enzyme showed absorption maximum at 280 nm and the value of E 1 % 1 CM AT 280 NM WAS 10 . 48 IN 0 . 05 M potassium phosphate buffer ( pH 7 . 0 ) . ^^^ |
|
| Interacting proteins: P42768 and Q06187 |
Pubmed |
SVM Score :0.0 |
| The amount of antibody produced to DNP KLH WAS MEASURED AT INTERVALS . ^^^ |
|
| Interacting proteins: P42768 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Although the 10 linked immunodeficiencies 10 linked agammaglobulinemia ( XLA ) , 10 linked severe combined immunodeficiency ( XSCID ) , Wiskott Aldrich syndrome ( WAS ) , 10 linked lymphoproliferative syndrome and 10 linked hyper IgM syndrome have been mapped to loci distributed throughout the 10 chromosome , they have several features in common that suggest that they might be members of a gene family : ( 1 ) all are maintained in the population at approximately the same gene frequency ; ( 2 ) expression of each defect is limited to the hematopoietic system ; ( 3 ) atypical forms of each disorder have been described ; and ( 4 ) obligate carriers of these disorders are normal by all immunologic criteria . ^^^ The failure of carriers of XLA , XSCID , and WAS to show signs of their gene defects can be explained by the preferential use of the normal , nonmutant 10 as the active 10 in the cell lineages affected by the gene defects . ^^^ These three disorders also share an additional feature ; in boys with XLA , XSCID , or WAS there is asynchronous expression of cell surface markers of differentiation or activation . ^^^ |
|
| Interacting proteins: P42768 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Epstein Barr virus transformed B lymphoblastoid cell lines ( EBV transformed LCL ) from three patients with 10 linked agammaglobulinaemia ( XLA ) , six patients with Wiskott Aldrich Syndrome ( WAS ) , and seven normal donors , were tested for growth and differentiation in response to human recombinant IL 4 , a commercially available , low molecular weight B cell growth factor ( BCGFlow ) , and B cell differentiation factor ( BCDF ) secreted by the T 24 cell line , now known to be IL 6 . ^^^ Proliferation ( 3H TdR uptake ) by EBV transformed LCL from both XLA and WAS patients in response to BCGFlow was similar to that obtained with the normal cell lines . ^^^ In addition , three normal and three WAS , but none of the XLA EBV transformed LCL , proliferated a little in response to IL 4 . ^^^ The lack of detectable IgG secretion by the XLA lines was probably due to an absence of precommitted IgG B cell precursors transformed by EBV rather than an intrinsic inability to respond to BCGF and BCDF . ^^^ These results suggest that the abnormal 10 linked genes responsible for XLA and WAS do not interfere with B cell responses to B cell growth and differentiation factors . . ^^^ |
|
| Interacting proteins: P42768 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Lymphomas occurred in 3 of 16 Japanese patients with ataxia telangiectasia ( AT ) and Wiskott Aldrich syndrome ( WAS ) . ^^^ |
|
| Interacting proteins: P42768 and Q06187 |
Pubmed |
SVM Score :0.0 |
| According to the clinical and laboratory features , the patients were classified as one case of severe combined immunodeficiency ( SCID ) , two of ataxia telangiectasia ( AT ) , one of Wiskott Aldrich syndrome ( WAS ) , one of DiGeorge syndrome ( DSG ) , and one of cellular immunodeficiency ( CID ) . ^^^ |
|
| Interacting proteins: P42768 and Q06187 |
Pubmed |
SVM Score :0.0 |
| In patients with AT and WAS these mechanisms may include NK cell activity , which is not depressed in these syndromes , whereas in patients with CHS , they may involve T cell cytotoxicity . . ^^^ |
|
| Interacting proteins: P42768 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Carrier detection in 10 linked immunodeficiencies ( 10 SCID , WAS , XLA ) relies on the demonstration of non random 10 inactivation patterns in blood cell lineages . ^^^ |
|
| Interacting proteins: P42768 and Q06187 |
Pubmed |
SVM Score :0.0 |
| The genes underlying four 10 linked defects in humans ( 10 linked agammaglobulinemia XLA , 10 linked severe combined immunodeficiency XSCID , hyper IgM syndrome HIGM 1 , and Wiskott Aldrich syndrome WAS ) , have recently been identified . ^^^ |
|
| Interacting proteins: P42768 and Q06187 |
Pubmed |
SVM Score :0.0 |
| The congenital immunodeficiencies most commonly associated with LPD include Wiskott Aldrich syndrome ( WAS ) , common variable immunodeficiency ( CVID ) , ataxia telangiectasia ( AT ) , severe combined immunodeficiency ( SCID ) , 10 linked lymphoproliferative disorder ( XLP ) , and hyper IgM syndrome . ^^^ |
|
| Interacting proteins: P42768 and Q06187 |
Pubmed |
SVM Score :0.0 |
| The Wiskott Aldrich syndrome ( WAS ) , 10 linked severe combined immunodeficiency ( SCIDX 1 ) , and 10 linked agammaglobulinemia ( XLA ) are severe congenital immunodeficiencies with 10 linked inheritance . ^^^ For patients with WAS , SCIDX 1 or XLA , the demonstration of non random 10 Chromosome inactivation in their mothers can be used to confirm clinical diagnosis . ^^^ In our study , 50 females with a known family history of XLA [ 19 ] , WAS [ 18 ] , and SCIDX 1 [ 13 ] , were examined . ^^^ A carrier status was established in 19 females ( 7 XLA , 6 WAS , 6 SCIDX 1 ) and excluded in 29 ( 11 XLA , 11 WAS , 7 SCIDX 1 ) . ^^^ |
|
| Interacting proteins: P42768 and Q06187 |
Pubmed |
SVM Score :0.0 |
| At present , international mutation databases have information for > 1 , 000 immunodeficiency patients , including 10 linked chronic granulomatous disease ( XCGD ) , Wiskott Aldrich syndrome ( WAS ) , and 10 linked thrombocytopenia ( XLT ) , 10 linked hyper IgM syndrome ( XHIM ) , 10 linked agammaglobulinemia ( XLA ) , and 10 linked severe combined immunodeficiency ( XSCID ) . ^^^ |
|
| Interacting proteins: P42768 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Unrelated donor bone marrow transplantation ( URD BMT ) has been performed in 18 patients with various diagnoses : SCID ( 8 ) , Wiskott Aldrich syndrome ( WAS ) ( 2 ) , Chediak Higashi syndrome ( CHS ) ( 2 ) , combined immunodeficiencies ( 3 ) , Ataxia Telangiectasis ( AT ) ( 2 ) , and one patient with combined immunodeficiency and large granular lymphocytosis ( 1 ) . ^^^ |
|
| Interacting proteins: P42768 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Training was carried out on cycle ergometers with 5 training units weekly at 40 minutes each . ^^^ |
|
| Interacting proteins: P42768 and Q06187 |
Pubmed |
SVM Score :0.0 |
| RESULTS OF RADIATION THERAPY IN PATIENTS WITH INOPERABLE CARCINOMA OF THE LUNG WHOSE STATUS WAS ESTABLISHED AT EXPLORATORY THORACOTOMY . ^^^ |
|
| Interacting proteins: P42768 and Q06187 |
Pubmed |
SVM Score :0.0 |
| ON 2 CASES OF OVARIAN PREGNANCY , OF WHICH ONE WAS AT THE EIGHTH MONTH . ] . ^^^ |
|
| Interacting proteins: P42768 and Q06187 |
Pubmed |
SVM Score :0.0 |
| AT LAST JUSTICE WAS DONE . ^^^ |
|
| Interacting proteins: P42768 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Was also observed the effects of losartan and CGP42112A ( select ligands of the AT ( 1 ) and AT ( 2 ) ANG 2 receptors , respectively ) injected into LSA prior AVP on the same appetites . ^^^ |
|
| Interacting proteins: P42768 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|