| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Because 72 kD tyrosine kinase was distinct from Syk , Tec , and Btk and coimmunoprecipitated with anti Stat antiserum , we termed it Stat associated 72 kD tyrosine kinase ( p72sak ) . p72sak may directly activate Stat family proteins or other signal transducing molecules for IL 3 , G CSF , and the IL 6 related cytokine subfamily . . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Association and activation of Btk and Tec tyrosine kinases by gp 130 , a signal transducer of the interleukin 6 family of cytokines . ^^^ In this study we show that in addition to Jak family tyrosine kinase , the stimulation of gp 130 by IL 6 plus soluble IL 6 receptor alpha induced the activation of Btk and Tec tyrosine kinases , whereas IL 3 and granulocyte colony stimulating factor activated Tec but not Btk in a pro B cell line . ^^^ Furthermore , both Btk and Tec kinases were associated with gp 130 without the ligand stimulation . ^^^ Because Btk is a critical tyrosine kinase for B lymphopoiesis and Tec is considered to be involved in hematopoiesis , the results suggest the involvement of gp 130 Btk Tec signal pathway in early lymphohematopoiesis . . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| We previously showed that gp 130 stimulation rapidly activates Jak , Btk , and Tec tyrosine kinases , all of which constitutively associate with gp 130 . ^^^ Furthermore , Fes associated with gp 130 independently of ligand stimulation like Jak , Btk , and Tec tyrosine kinases . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Sequence analysis indicates that txk contains SH 2 , SH 3 and kinase catalytic domains and belongs to the tec family of cytoplasmic protein tyrosine kinases which includes tec , itk and btk . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Btk and two related proteins , Itk and Tec , are members of a distinct family of tyrosine kinases . ^^^ Btk and its homologues share extensive sequence similarity , including a conserved region , the Tec homology ( TH ) domain , that has been proposed to mediate specific intermolecular or intramolecular interactions . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Among cytoplasmic protein tyrosine kinases ( PTKs ) Tec now forms a novel subfamily with recently identified Tec related PTKs ( Btk and Itk / Tsk ) . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| The sequence of rlk showed that it is most closely related to the subfamily of cytoplasmic tyrosine kinases that includes the Btk , Itk , and Tec proteins . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| The predicted human Tec protein is highly homologous to those of the members of the Tec family including mouse Tec type 4 ( 94 % homology ) , mouse Tsk / Itk ( 60 % ) , and human Btk ( 57 % ) . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| TXK , like BTK , is a member of the Tec sub family of Src type ( non receptor ) tyrosine kinases . ^^^ TXK shares 60 % amino acid homology with EMT and 57 % with BTK over the SH 3 , SH 2 ( Src homology ) and catalytic domains but unlike BTK , EMT and tec , it lacks Gap 1 homology and steroid hormone receptor homology in the N terminal region . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| BMX , a novel nonreceptor tyrosine kinase gene of the BTK / ITK / TEC / TXK family located in chromosome Xp22 . 2 . ^^^ Bmx cDNA comprises a long open reading frame of 675 amino acids , containing one SH 3 , one SH 2 and one tyrosine kinase domain , which are about 70 % identical with Btk , Itk and Tec and somewhat less with Txk tyrosine kinase sequences . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| This observation is consistent with the classification of Btk together with the recently characterized kinases , Tec and Itk , into a separate sub family of cytoplasmic PTKs . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| The pleckstrin homology ( PH ) domain is extended in the Btk kinase family by a region designated the TH ( Tec homology ) domain , which consists of about 80 residues preceding the SH 3 domain . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Genomic organization and structure of Bruton agammaglobulinemia tyrosine kinase : localization of mutations associated with varied clinical presentations and course in 10 chromosome linked agammaglobulinemia . 10 chromosome linked agammaglobulinemia is a life threatening disease that involves a failure in normal development of B lymphocytes and is associated with missense mutations in BTK , a gene encoding a cytoplasmic tyrosine kinase ( Bruton agammaglobulinemia tyrosine kinase , EC 2 . 7 . 1 . 112 ) , a member of the Tec family of protein tyrosine kinases . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| The Tec family is a recently emerging subfamily among nonreceptor type protein tyrosine kinases ( PTKs ) consisting of Tec , Txk , Btk , Bmx , and Itk / Tsk / Emt . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| The genomic organization of Txk consists of 15 exons with strong exon intron organizational homology to Btk , the only other Tec family kinase for which the genomic structure is fully known . ^^^ The human Tec gene also maps to 4p12 and , based on limited studies reported here , possesses organizational homology with Btk and Txk . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Bruton ' s tyrosine kinase ( BTK ) is a member of the SRC related TEC family of protein tyrosine kinases ( PTKs ) . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Itk is a T cell protein tyrosine kinase ( PTK ) that , along with Btk and Tec , belongs to a family of cytoplasmic PTKs with N terminal pleckstrin homology domains . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Btk and the other family members , Tec , ltk and Bmx , contain five regions , four of which are common structural and functional modules that are found in other signaling proteins . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| The Tec family of cytoplasmic tyrosine kinases , which include Btk ( the 10 linked agammaglobulinemia gene ) , Itk , and Tec , is thought to be involved in lymphoid cell signaling pathways . ^^^ In this work , we show binding of WASP to the Src homology 3 domains of Btk , Itk , Tec , Grb 2 , and phospholipase C gamma , which suggests a function for WASP in lymphoid cell signaling . . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| The molecules discussed include Src family kinases , Syk , Grb 2 adaptor protein , and Tec family kinases Bmx and Btk . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| We recently demonstrated that the PH domains of Tec family protein tyrosine kinases Btk and Emt ( equal to Itk and Tsk ) interact with protein kinase C ( PKC ) and that PKC down regulates Btk by phosphorylation . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Btk along with Tec , Itk and Bmx belong to a distinct family of protein kinases . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Tec / Btk tyrosine kinases are members of a subgroup of Src tyrosine kinase family . ^^^ Here we show the association between Jak1 / Jak2 and Tec or Jak 1 and Btk . ^^^ Furthermore , Jak 1 but not Jak 2 induces tyrosine phosphorylation of Btk , but not Tec . ^^^ These observations suggest that upon cytokine stimulation JAKs activate Tec / Btk or induce their dimerization resulting in endogenous tyrosine phosphorylation . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| In this paper , we describe the inositol phosphate binding specificity of the Btk PH domain and different inositol polyphosphate binding properties among the PH domains of Tec family kinases . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Btk is a member of the Tec family of cytosolic protein tyrosine kinases with distinct functional domains PH , TH , SH 3 , SH 2 , and kinase . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Mutations in Bruton ' s tyrosine kinase ( Btk ) belonging to the Tec family cause 10 linked agammaglobulinemia ( XLA ) due to developmental arrest of B cells . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Members of the hematopoietically expressed Tec tyrosine kinase family have an important role in hematopoietic signal transduction , as exemplified by the crucial role of Btk for B cell differentiation and activation . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Tec was also highly expressed in two EBV transformed lymphoblastoid lines derived from patients with 10 linked agammaglobulinemia ( XLA ) lacking Btk expression , as well as in tonsillar lymphoid cells . ^^^ The tyrosine kinase Tec belongs to a new group of structurally related nonreceptor tyrosine kinases that also includes Btk and Itk . ^^^ Like Btk , Tec protein was expressed in all B cell lines tested . ^^^ Likewise , cross linking of CD 19 with a monoclonal antibody in BCR negative pro B ( RS 4 ; 11 , 380 ) and pre B ( NALM 6 ) cells induced Tec tyrosine phosphorylation and increased Tec autophosphorylation , as well as Btk activation . ^^^ Tyrosine phosphorylation of Tec , but not of Btk , was detectable in RS 4 ; 11 cells after CD 38 ligation , suggesting that these kinases are regulated differently . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Btk belongs to the Tec family of tyrosine kinases . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Interestingly , the non src kinase syk was not activated in CD 72 stimulated cells whereas the tec family kinase btk was activated in both CD 72 and BCR stimulated B cells . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| PLC gamma 2 activation in EMF stimulated cells is mediated by stimulation of the Bruton ' s tyrosine kinase ( BTK ) , a member of the Src related TEC family of protein tyrosine kinases , which acts downstream of LYN kinase and upstream of PLC gamma 2 . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| For all three SH 3 domains maximum stability was observed in the pH region 4 . 5 < pH < 7 . 0 where these domains unfold at temperatures of 353K ( Btk ) , 342K ( Itk ) , and 344K ( Tec ) . ^^^ At these temperatures an enthalpy change of 196 kJ / mol , 178 kJ / mol , and 169 kJ / mol was measured for Btk , Itk , and Tec SH 3 domains , respectively . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| The role of Tec kinases in cellular function is poorly understood , although a Tec kinase specific to B cells , Btk , is essential for B cell development . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| The Tec protein tyrosine kinase family includes Btk , Itk / Tsk / Emt , Tec , Rlk / Txk , and Bmx which are involved in signals mediated by various cytokines or antigen receptors . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Bruton ' s tyrosine kinase ( BTK ) is a member of the Src related Tec family of protein tyrosine kinases . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Bruton tyrosine kinase ( Btk ) plays a crucial role in the differentiation of B lymphocytes and belongs to the group of Tec kinases , which are characterised by the presence of a pleckstrin homology domain . ^^^ Bruton tyrosine kinase ( Btk ) plays a crucial role in the differentiation of B lymphocytes and belongs to the group of Tec kinases , which are characterised by the presence of a pleckstrin homology domain . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Reconstitution of Btk signaling by the atypical tec family tyrosine kinases Bmx and Txk . ^^^ Btk is a member of the Tec family of nonreceptor protein tyrosine kinases that includes Bmx , Itk , Tec , and Txk . ^^^ Itk and Tec have recently been shown to reconstitute PLCgamma 2 dependent signaling in Btk deficient human cells , but it is not known whether the atypical Tec family members , Bmx and Txk , can reconstitute function . ^^^ Here we reconstitute Btk deficient DT 40 B cells with Bmx and Txk to compare their function with other Tec kinases . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Comparison of mouse and human Btk , human TXK , and mouse Tec genomic structures shows a high level of conservation of exon / intron boundaries . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| The Tec protein tyrosine kinase ( PTK ) family includes Btk , Itk / Tsk / Emt , Tec , Rlk / Txk and Bmx , which are involved in signals mediated by various surface receptors . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Furthermore , the lead dimethoxyquinazoline compound , WHI P 131 , which showed potent JAK 3 inhibitory activity ( IC 50 of 78 microM ) , did not inhibit JAK 1 and JAK 2 , the ZAP / SYK family tyrosine kinase SYK , the TEC family tyrosine kinase BTK , the SRC family tyrosine kinase LYN , or the receptor family tyrosine kinase insulin receptor kinase , even at concentrations as high as 350 microM . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Btk and other Tec family tyrosine kinases have a pleckstrin homology ( PH ) domain at their N termini . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Btk is a member of the Tec family of protein tyrosine kinases expressed in B cells . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Tec , Btk , Itk , Bmx , and Txk constitute the Tec family of protein tyrosine kinases ( PTKs ) , a family with the distinct feature of containing a pleckstrin homology ( PH ) domain . ^^^ In 293 cells expressing recombinant BRDG 1 and various PTKs , Tec and Pyk 2 , but not Btk , Bmx , Lyn , Syk , or c Abl , induced marked phosphorylation of BRDG 1 on tyrosine residues . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| The structures for the PH domains of Bmx , Itk , and Tec were modelled based on Btk structure . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| This process requires expression of SLP adaptors and involves phosphorylation of phospholipase C gamma isoforms by the Tec related protein tyrosine kinase Btk in B cells and Itk in T cells . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Bruton ' s tyrosine kinase ( Btk ) is a member of the Tec family of protein tyrosine kinases ( PTK ) characterized by an N terminal pleckstrin homology domain ( PH ) thought to directly interact with phosphoinositides . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| The Tec family has emerged recently as a subfamily among nonreceptor type protein tyrosine kinases , consisting of Tec , Btk , Itk / Tsk / Emt , Bmx , and Txk / Rlk . ^^^ Although that hypothesis was further strengthened by the knowledge that mutations in Btk cause agammaglobulinemia in humans , we have only limited information concerning the molecular interaction through which Tec kinases exert their effects . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| This family is composed of five members , namely Tec , Btk . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| In XLA platelets , collagen treatment increased tyrosine phosphorylation of Tec and several other signaling proteins , including Lyn , Fyb , Slp 76 , and the Wiskott Aldrich syndrome protein . ^^^ The results are consistent with the conclusion that activation of Tec may sustain XLA platelet function in vivo , while some in vitro assays of nonintegrin collagen receptor signaling through the Btk / Tec kinase family reflect the additive dosage of the transducers . ( Blood . 2000 ; 95 : 1663 1670 ) . ^^^ A key transducer of the lymphocyte signaling pathways is the Bruton ' s tyrosine kinase ( Btk ) / Tec kinase family , which connects receptors to the elevation of intracellular free calcium levels . ^^^ Since Btk deficiency does not induce an overt platelet based bleeding disorder in vivo , collagen receptor responses may include other Btk / Tec kinase family members in normal platelets . ^^^ Both Btk and Tec had increased tyrosine following stimulation of collagen receptors or CD 32 cross linking . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Bruton ' s tyrosine kinase ( BTK ) , a member of the Tec family of tyrosine kinases , is essential for the full repertoire of IgM signals to be transduced . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Several protein tyrosine kinases are activated rapidly following engagement of the BCR / preBCR complexes , including members of the Src family ( Lyn and Blk ) , the Syk / ZAP70 family ( Syk ) , and the Tec family ( Btk ) . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Interestingly , we note a striking correlation between the SH 2 residues that mediate this interaction and those residues that , when mutated in the Tec family member Btk , cause the hereditary immune disorder , 10 linked agamaglobulinemia . . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| In addition , Tec ( but not Btk ) kinase can also be activated by PTPD 1 . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Bruton ' s tyrosine kinase ( Btk ) , a nonreceptor cytoplasmic tyrosine kinase belonging to the Tec family of kinases , has been shown to be critical for B cell proliferation , differentiation , and signaling . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| The Tec protein kinase family includes Btk , Itk , Tec , Rlk and Bmx , which are critically involved in signals mediated by various cytokines and antigen receptors . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Bruton ' s tyrosine kinase ( Btk ) is a cytoplasmic protein tyrosine kinase consisting of N terminal pleckstrin homology ( PH ) domain followed by Tec homology ( TH ) domain , Src homology 3 and 2 ( SH 3 and SH 2 ) domains , and a C terminal kinase domain . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Btk along with Tec , Itk , Bmx and Txk belong to a distinct family of protein kinases . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| The ability of Tec to compensate for Btk may also explain phenotypic differences in 10 linked immunodeficiency ( xid ) mice compared with human 10 linked agammaglobulinemia ( XLA ) patients . . ^^^ Severe B cell deficiency in mice lacking the tec kinase family members Tec and Btk . ^^^ To reveal potential compensatory roles of other Tec kinases such as Bruton ' s tyrosine kinase ( Btk ) , Tec / Btk double deficient mice were generated . ^^^ Although Tec / Btk ( null ) mice were able to form germinal centers , the response to T cell dependent antigens was impaired . ^^^ Thus , Tec and Btk together have an important role both during B cell development and in the generation and / or function of the peripheral B cell pool . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| The Btk family kinases represent new members of non receptor tyrosine kinases , which include Btk / Atk , Itk / Emt / Tsk , Bmx / Etk , and Tec . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| The SH 3 domain of Bruton ' s tyrosine kinase ( Btk ) is preceded by the Tec homology ( TH ) region containing proline rich sequences . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| ATP activates the Btk tyrosine kinase , Tec , and induces its association with PLCgamma . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Three major classes of signalling molecule are regulated by binding of D 3 phosphoinositides to PH domains : guanine nucleotide exchange proteins for Rho family GTPases , the TEC family tyrosine kinases such as BTK and ITK in B and T lymphocytes , respectively , and the AGC superfamily of serine / threonine protein kinases . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| The importance of the Tec family of kinases was immediately recognized when , in 1993 , mutations in the gene encoding Bruton ' s tyrosine kinase ( Btk ) were reported to cause the human disease 10 linked agammaglobulinemia ( XLA ) . ^^^ The Tec family of cytoplasmic tyrosine kinases : mammalian Btk , Bmx , Itk , Tec , Txk and homologs in other species . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Bruton ' s tyrosine kinase ( Btk ) , a member of the Tec family of cytosolic kinases , is essential for B cell development and function . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| To understand the possible role of the unique pleckstrin homology and Tec homology ( PHTH ) module of Btk , we have compared the enzymatic properties of full length Btk and a Btk mutant lacking the PHTH module ( BtkDeltaPHTH ) . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| We identified a highly conserved PKCbeta serine phosphorylation site in a short linker within the Tec homology domain of Btk . ^^^ These findings provide a novel mechanism whereby reversible translocation of Btk / Tec kinases regulates the threshold for immunoreceptor signaling and thereby modulates lymphocyte activation . . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Tec is the prototypic member of a family of intracellular tyrosine kinases that includes Txk , Bmx , Itk , and Btk . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| The Tec homology ( TH ) region located N terminal to the Src homology 3 ( SH 3 ) domain of Bruton ' s tyrosine kinase ( Btk ) contains two proline rich SH 3 binding sequences ( PRRs ) . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Tec and Btk , another member of this family , together participate in the development of B cell immune system . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| A nuclear magnetic resonance ( NMR ) investigation of a fragment of the nonreceptor Tec family tyrosine kinase Btk has revealed an intricate set of coupled monomer dimer equilibria . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Bruton ' s tyrosine kinase ( Btk ) , a member of the Tec family of protein tyrosine kinases , has been shown to be crucial for B cell development , differentiation , and signaling . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Bruton tyrosine kinase ( Btk ) of the Tec family contains in the Tec homology ( TH ) domain a proline rich region ( PRR ) capable of interacting with several SH 3 domains . ^^^ Bruton tyrosine kinase ( Btk ) of the Tec family contains in the Tec homology ( TH ) domain a proline rich region ( PRR ) capable of interacting with several SH 3 domains . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| The results obtained indicate firstly that several members of the Tec family of tyrosine kinases are expressed in human neutrophils , including Tec , Btk , and Bmx . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Btk , another member of Tec family tyrosine kinase , has been shown to have a Src family tyrosine kinase dependent transphosphorylation site and an autophosphorylation site . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Tec family tyrosine kinases , Bruton ' s tyrosine kinase ( Btk ) , Itk , Bmx , Tec , and Txk , are multi domain proteins involved in hematopoietic signaling . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| The Tec kinase Bruton ' s tyrosine kinase ( Btk ) represents a key intermediary for B cell receptor ( BCR ) signaling . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Significant attenuation of CRP induced tyrosine phosphorylation in known PI3K effectors such as Btk , Tec , PKB / Akt , and phospholipase Cgamma 2 were observed with p85alpha / platelets , whereas no alteration was noted in upstream molecules of Syk , LAT , and SLP 76 . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| LFM A 13 also negatively affected the translocation of Rac 2 , RhoA , ADP ribosylation factor 1 , Tec , Bmx , and Btk induced by fMet Leu Phe . ^^^ The results of this study provide evidence for an involvement of Btk and possibly other Tec kinase family members in the regulation of the functional responsiveness of human neutrophils and link these events , in part at least , to the modulation of levels of phosphatidylinositol 3 , 4 , 5 trisphosphate . . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| This study provides the first clear evidence that tyrosine kinases of the Tec family , in particular Btk , are key elements of LPS induced TNF alpha production and consequently may provide valuable therapeutic targets for intervention in inflammatory conditions . . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Tec regulates platelet activation by GPVI in the absence of Btk . ^^^ The Tec family kinase Btk plays an important role in the regulation of phospholipase C gamma 2 ( PLC gamma 2 ) downstream of the collagen receptor glycoprotein 6 ( GPVI ) in human platelets . ^^^ To address the role of Tec , we analyzed Btk / , Tec / , and Btk / Tec double deficient ( Btk / / Tec / ) platelets . ^^^ However , Btk / / Tec / platelets exhibit a greater reduction in PLC gamma 2 phosphorylation than is seen in the absence of Btk , thus revealing an important role for Tec in this situation . ^^^ Furthermore , Btk / / Tec / platelets fail to undergo an increase in Ca2+ , aggregation , secretion , and spreading in response to collagen or CRP , whereas they aggregate normally to adenosine diphosphate ( ADP ) and spread on fibrinogen . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Like Src and Abl PTKs , Btk contains a conserved cassette formed by SH 3 , SH 2 and protein kinase domains , but differs from them by the presence of an N terminal PH domain and the Tec homology region . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| The leflunomide metabolite analog alpha cyano beta hydroxy beta methyl N ( 2 , 5 dibromophenyl ) propenamide ( LFM A 13 ) is a rationally designed specific inhibitor of the TEC family protein tyrosine kinase , Bruton ' s tyrosine kinase ( BTK ) which plays an important role in platelet physiology by regulating the glycoprotein GPVI FcRgamma coupled collagen receptor signaling pathway . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Bruton ' s tyrosine kinase ( BTK ) is a member of the Tec family of kinases , which is a subgroup of the nonreceptor cytoplasmic protein tyrosine kinases . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Here we show that BTK , a member of the Tec family of cytoplasmic protein tyrosine kinases , associates with phosphatidylinositol 4 phosphate 5 kinases ( PIP5Ks ) , the enzymes that synthesize PtdIns 4 , 5 P 2 . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| The Tec kinase Btk is an important regulator of antigen receptor activation of phospholipase C gamma ( PLC gamma ) . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| The Tec family member Bruton ' s tyrosine kinase ( Btk ) is a cytoplasmic protein tyrosine kinase that transduces signals from the pre B and B cell receptor ( BCR ) . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Expression and function of Tec , Itk , and Btk in lymphocytes : evidence for a unique role for Tec . ^^^ The Tec protein tyrosine kinase is the founding member of a family that includes Btk , Itk , Bmx , and Txk . ^^^ In this study , we show that Tec protein is expressed at substantially lower levels in primary T and B cells relative to Itk and Btk , respectively . ^^^ Tec induced NFAT activation requires PLC gamma , but not the adapters LAT , SLP 76 , and BLNK , which are required for Btk and Itk to couple to PLC gamma . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| The highest homology ( 38 % identity , 55 % overall similarity ) was found with human BTK and TEC PTKs . ^^^ Our finding implies that the BTK / TEC genes are of a very ancient origin . . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| We found that Btk ( Bruton ' s tyrosine kinase ) , a member of the Tec family of cytoplasmic protein tyrosine kinases , is constitutively associated with PIP5Ks ( phosphatidylinositol 4 phosphate 5 kinases ) , the enzymes that synthesize PtdIns ( 4 , 5 ) P 2 . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Molecular basis for this disease is more than 400 mutation in one of Tec kinases Bruton ' s tyrosine kinase ( Btk ) which affects B cell maturation through impaired B cell receptor signaling . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Bruton tyrosine kinase ( Btk ) , a non receptor associated tyrosine kinase of the Tec family , appears to participate in many myeloid cell functions . ^^^ Bruton tyrosine kinase ( Btk ) , a non receptor associated tyrosine kinase of the Tec family , appears to participate in many myeloid cell functions . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Members of the Tec kinase family ( Bmx , Btk , Itk , Rlk and Tec ) are primarily expressed in the hematopoietic system and form , after the Src kinase family , the second largest class of non receptor protein tyrosine kinases . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Mutations in Bruton ' s tyrosine kinase ( BTK ) , a member of Tec Family of protein tyrosine kinases , have been found to be mainly responsible for XLA disease . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| BTK ( Bruton ' s tyrosine kinase ) is a member of the TEC family of tyrosine kinases that plays a central but diverse modulatory role in various cellular processes . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Together , these data support a model whereby Btk / Tec kinases control sustained calcium signaling via site specific phosphorylation of key residues within the PLCgamma 2 SH2 SH 3 linker . . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| The Btk Y617E mutant could partially restore conventional B cell development and proliferation in Btk ( ) / Tec ( ) mice but failed to rescue CD 5 ( + ) B 1 cell development and the TI 2 immune response to 2 , 4 , 6 , trinitrophenyl Ficoll . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| The Tec family of protein tyrosine kinases ( PTKs ) , that includes Tec , Itk , Btk , Bmx , and Txk , plays an essential role in phospholipase Cgamma ( PLCgamma ) activation following antigen receptor stimulation . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Btk is a member of the Tec family of protein tyrosine kinases ( PTKs ) and plays a vital , but diverse , modulatory role in many cellular processes . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| We have compared acute and late phase allergic airway reactions in mice lacking either Btk or interleukin 2 inducible T cell kinase ( Itk ) , another Tec kinase expressed in mast cells . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| With this technique , we showed that , in live T cells , the Tec vesicles are located at the plasma membrane , the vesicles are unique to Tec ( and not the related kinase Itk ) , and their formation and maintenance require T cell receptor signaling through Src family kinases and PI 3 kinase . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Drosophila type 2 Btk29A reveals the highest homology to Btk among mammalian Tec kinases . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| To determine if the specific mutation in Btk might be one of the factors that influences the severity of disease or if polymorphic variants in Tec , a cytoplasmic tyrosine kinase that might substitute for Btk , could contribute to the clinical phenotype , we examined the age at diagnosis , the percentage of peripheral blood B cells and the plasma IgM in a large group of patients with XLA . ^^^ The results demonstrated that polymorphic variants in Tec were not correlated with phenotypic markers ; however , the specific mutation in Btk did influence disease severity . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| These results demonstrate that the Btk family kinase , Tec , can not provide the function ( s ) missing because of the absence of Btk and that Btk is essential for both bt / VWF mediated agglutination induced TxA 2 production and GPIb dependent stable arterial thrombus formation in vivo . . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Proteomics approaches permitted the identification of tyrosine kinases from three families : Src ( Lyn ) , Csk , and Tec ( Bmx , Btk ) . ^^^ |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42680 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|