| Interacting proteins: P42229 and Q06187 |
Pubmed |
SVM Score :0.0 |
| The latter mutation changes an amino acid sequence in the STAT5A protein a Val / Ala substitution at position 686 . ^^^ |
|
| Interacting proteins: P42229 and Q06187 |
Pubmed |
SVM Score :0.0 |
| IL 5 induces tyrosine phosphorylations of cellular proteins including ( beta ) c and STAT 5 and activates Btk . 10 linked immunodeficient mice have B cell specific defects due to missense mutation of the btk gene . ^^^ |
|
| Interacting proteins: P42229 and Q06187 |
Pubmed |
SVM Score :0.0 |
| In BTK competent chicken B cells , anti IgM stimulated tyrosine phosphorylation of STAT 5 protein was prevented by pretreatment with the BTK inhibitor LFM A 13 but not by pretreatment with the JAK 3 inhibitor HI P 131 . ^^^ B cell antigen receptor ligation resulted in enhanced tyrosine phosphorylation of STAT 5 in BTK deficient chicken B cells reconstituted with wild type human BTK but not in BTK deficient chicken B cells reconstituted with kinase inactive mutant BTK . ^^^ |
|
| Interacting proteins: P42229 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Deficiency of Btk results in reduced and delayed phosphorylation of the EpoR , Jak 2 , and downstream signaling molecules such as Stat 5 and PLCgamma 1 as well as in decreased responsiveness to Epo . ^^^ |
|
| Interacting proteins: P42229 and Q06187 |
Pubmed |
SVM Score :0.0 |
| The cytoplasmic tyrosine kinase Bruton ' s tyrosine kinase ( Btk ) was found to be phosphorylated by Jak 2 in response to Epo and appeared to be required for fast and efficient phosphorylation of Epo induced targets including the EpoR itself and downstream targets such as PLCgamma and Stat 5 . ^^^ |
|
| Interacting proteins: P42229 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Activation of Btk and Jak 2 kinases , rapid tyrosine phosphorylation of betac , adaptor proteins and transcription factors STAT 5 ; and inductions of transcription of several nuclear proto oncogenes are essential for the IL 5 signal transduction . ^^^ |
|
| Interacting proteins: P42229 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42229 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42229 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42229 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42229 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42229 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42229 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42229 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42229 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42229 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42229 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42229 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|