| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.97039077 |
| In contrast , BTK associates with the death receptor Fas and impairs its interaction with Fas associated protein with death domain ( FADD ) , which is essential for the recruitment and activation of FLICE by Fas during the apoptotic signal , thereby preventing the assembly of a pro apoptotic death inducing signaling complex ( DISC ) after Fas ligation . 0.97039077^^^ |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.7461061 |
| BTK associates with Fas via its kinase and PH domains and prevents the FAS FADD interaction , which is essential for the recruitment and activation of FLICE by Fas during the apoptotic signal . 0.7461061^^^ |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Interestingly , in the presence of cycloheximide , the kinetics of cell killing was more rapid for TNF than anti Fas ( 50 % inhibition occurred at 3 versus 6h ) . ^^^ |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Current data suggest that the main function of Fas may be in regulation of the immune response and apparently less at the level of an effector mechanism in host defense . ^^^ |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| TCR triggered FasL / Fas cytotoxicity is detectable in CD8+ and Th 1 clones by 3 h and peaks at 6 h ; high levels of killing are maintained for at least 24 h . ^^^ Similarly , IL 2 induces FasL / Fas killing in CD8+ and Th 1 clones within 3 h of stimulation and maintains high levels for at least 24 h . ^^^ |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| The mechanisms involved in the nutritional regulation of genes encoding lipogenic ( lipoprotein lipase ( LPL ) and fatty acid synthase ( FAS ) ) and lipolytic ( hormone sensitive lipase ( HSL ) ) enzymes were investigated by comparing the levels of the corresponding mRNAs in the adipose tissue ( AT ) of underfed or underfed refed ewes and cows . ^^^ Northern blot analysis revealed three LPL transcripts and a single FAS transcript in cow and ewe AT . ^^^ |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Proximate mediators for Fas resistance include the known anti apoptotic gene products Bcl xL and FLIP ( but not Btk ) , and a novel anti apoptotic gene that encodes Fas apoptosis inhibitory molecule ( FAIM ) . ^^^ |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Several studies have shown that ionizing radiation induces transcription of the TNFRSF 6 ( Fas ) gene , leading to augmented TNFRSF 6 protein levels at the surface of irradiated cells . ^^^ |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Further , surface immunoglobulin signaling for inducible Fas resistance bypasses Btk , requires NF kappaB , and entails new macromolecular synthesis . ^^^ |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Refeeding increased ( 2 . 6 4 . 3 fold ) malic enzyme ( ME ) , fatty acid synthase ( FAS ) , glucose 6 phosphate dehydrogenase ( G6PDH ) and glycerol 3 phosphate dehydrogenase ( G3PDH ) activities in subcutaneous AT as well as lipoprotein lipase ( LPL ) activity in perirenal ( 3 . 5 fold ) and subcutaneous ( 10 fold ) AT and to a lesser extent ( 1 . 4 fold ) in the skeletal longissimus thoracis and cardiac muscles . ^^^ |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| The signaling mediator , Bruton ' s tyrosine kinase ( Btk ) , is required for certain sIg triggered responses , and Btk is reported to directly bind Fas and block Fas mediated apoptosis . ^^^ For these reasons , the role of Btk as a mediator of sIg induced Fas resistance was examined . ^^^ Dysfunction of Btk through mutation , and absence of Btk through deletion did not interfere with induction of Fas resistance by anti Ig . ^^^ However , the susceptibility to Fas mediated apoptosis of B cell targets stimulated by CD 40 ligand alone was increased in the absence of Btk . ^^^ These results indicate that Fas resistance produced by sIg triggering does not require Btk , but suggests that in certain situations Btk modulates B cell susceptibility to Fas killing . . ^^^ |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| These results suggest that ANG 2 induced apoptosis is mediated via both AT ( 1 ) and AT ( 2 ) receptors through the generation of TGF beta , followed by the transcription of cell death genes such as Fas , FasL , and Bax . ^^^ |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Previously , we demonstrated that mice that express LPL exclusively in muscle develop essentially normal fat mass despite the absence of LPL and the deprivation of nutritionally derived FAs in adipose tissue ( AT ) . ^^^ These results suggest that in the absence of LPL in AT , lipogenesis is activated through increased SREBP 1 expression and processing triggered by decreased availability of nutrition derived FAs , elevated insulin , and low leptin levels . . ^^^ |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| MCF 7 human breast cancer cells have low levels of Fas receptor ( FasR ) and are resistant to anti FasR antibody mediated apoptosis , however two naturally occurring substances , interferon and all trans retinoic acid ( AT ) , act synergistically to enhance antiproliferative processes in these cells , suggesting this combination may also be an effective means for enhancing FasR expression . ^^^ Expression of these proteins was not modulated by IFN / AT , however treatment of Fas induced cells with Bcl 2 specific small interfering RNA ( SiRNA ) downregulated Bcl 2 protein expression and rendered these cells sensitive to the cytotoxic effects of anti Fas antibody . ^^^ |
|
| Interacting proteins: P25445 and Q06187 |
Pubmed |
SVM Score :0.0 |
| In addition , both levels of Fas mRNA in liver tissues and Fas Ligand in spleen cells were up regulated at 6 h after the elicitation . ^^^ The Fas mRNA expression was maintained in a relatively high level at 18 h while Fas Ligand began to decrease after 12 h . ^^^ |
|