| Interacting proteins: P23458 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23458 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23458 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23458 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23458 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23458 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23458 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23458 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23458 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23458 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23458 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23458 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23458 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Of the 28 cDNA clones sequenced , 7 were JAK 1 TK , one was atk TK , one was tec TK . ^^^ |
|
| Interacting proteins: P23458 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Here we show the association between Jak1 / Jak2 and Tec or Jak 1 and Btk . ^^^ Furthermore , Jak 1 but not Jak 2 induces tyrosine phosphorylation of Btk , but not Tec . ^^^ |
|
| Interacting proteins: P23458 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Furthermore , the lead dimethoxyquinazoline compound , WHI P 131 , which showed potent JAK 3 inhibitory activity ( IC 50 of 78 microM ) , did not inhibit JAK 1 and JAK 2 , the ZAP / SYK family tyrosine kinase SYK , the TEC family tyrosine kinase BTK , the SRC family tyrosine kinase LYN , or the receptor family tyrosine kinase insulin receptor kinase , even at concentrations as high as 350 microM . ^^^ |
|
| Interacting proteins: P23458 and Q06187 |
Pubmed |
SVM Score :0.0 |
| JAK 1 , but not JAK 2 or Tyk 2 , was phosphorylated by IGF 1 as early as 2 minutes and peaked at 5 minutes . ^^^ Tyrosine phosphorylation of STAT 1 peaked at 15 minutes and correlated with that of JAK 1 , whereas that of STAT 3 was sustained up to 120 minutes and was dissociated from the activation of JAK 1 . ^^^ |
|
| Interacting proteins: P23458 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Of particular interest is WHI P 131 , which inhibits JAK 3 but not JAK 1 , JAK 2 , SYK , BTK , LYN , or IRK at concentrations as high as 350 microM . ^^^ |
|