| Interacting proteins: P15391 and Q06187 |
Pubmed |
SVM Score :0.82286926 |
| To identify physical and functional interactions between CD 19 and Btk , a CD 19 negative variant of the A 20 B cell line was isolated , and CD 19 deficient ( CD 19 ( / ) ) and CD 19 overexpressing mice with the 10 linked immunodeficient ( Xid ; Btk ) mutation were generated . 0.82286926^^^ |
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| Interacting proteins: P15391 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Obligate carriers of XLA demonstrated > 95 % skewing of 10 inactivation in peripheral blood CD19+ cells but not in CD 19 cells . ^^^ |
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| Interacting proteins: P15391 and Q06187 |
Pubmed |
SVM Score :0.0 |
| While immunoglobulin germline 1 mu RAG 1 , mb 1 , CD 19 , and lambda 5 transcripts are dramatically reduced in fetal livers of E2A ( / ) mice , B 29 and mu degrees transcripts are present , but at lower levels . ^^^ |
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| Interacting proteins: P15391 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Decrease in neutrophil alkaline phosphatase score and positive rate , and eosinophilia in bone marrow or the blast cells with Auer rods expressing CD 19 , CD 56 antigens occur at a relatively high rate . ^^^ |
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| Interacting proteins: P15391 and Q06187 |
Pubmed |
SVM Score :0.0 |
| In the non XLA case , CD 19 expression was also highly impaired in the bone marrow , resulting in the absence of both B and preB compartments . ^^^ Semi quantitative RT PCR analysis performed on mononuclear bone marrow cells from the non XLA patient indicated that lambda like , VpreB , Rag 1 , Rag 2 and TdT transcripts expressed during proB cell stages were found at normal levels whereas E2A , CD 10 , Syk , Pax 5 , CD 19 , Ig alpha , Ig beta , VH C mu and 5 kappa C kappa transcripts characteristic of later stages were severely depressed . ^^^ |
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| Interacting proteins: P15391 and Q06187 |
Pubmed |
SVM Score :0.0 |
| CD 19 expression begins at the pro B cell stage of B cell development . ^^^ In vivo footprinting identified protected regions over the known high affinity B cell lineage specific activator protein ( BSAP ) site , the low affinity BSAP site , a SP1 / Egr 1 site termed the CD 19 GC box , and two novel sites named the AT box and PyG box . ^^^ Gel shift assays demonstrated SP 1 and Egr 1 binding to the CD 19 GC box , while unknown nuclear proteins bound the PyG and AT boxes . ^^^ Mutations in the AT box or in the BSAP sites did not affect CD 19 reporter construct activity , while a mutation of the GC box reduced it modestly , and a PyG box mutation reduced it dramatically . ^^^ |
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| Interacting proteins: P15391 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Likewise , cross linking of CD 19 with a monoclonal antibody in BCR negative pro B ( RS 4 ; 11 , 380 ) and pre B ( NALM 6 ) cells induced Tec tyrosine phosphorylation and increased Tec autophosphorylation , as well as Btk activation . ^^^ |
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| Interacting proteins: P15391 and Q06187 |
Pubmed |
SVM Score :0.0 |
| In view of previous findings that CD 19 is involved in BCR mediated phosphatidylinositol 3 kinase ( PI 3 K ) activation , we assessed its role in Btk activation . ^^^ Using a CD 19 reconstituted myeloma model and CD 19 gene ablated animals we found that BCR mediated Btk activation and phosphorylation are dependent on the expression of CD 19 , while BCR mediated activation of Lyn and Syk is not . ^^^ Btk activation was not rescued in the myeloma by expression of a CD 19 mutant in which tyrosine residues previously shown to mediate CD 19 interaction with PI 3 K , Y 484 and Y 515 , were changed to phenylalanine . ^^^ Taken together , the data presented indicate that BCR aggregation driven CD 19 phosphorylation functions to promote Btk activation via recruitment and activation of PI 3 K . ^^^ |
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| Interacting proteins: P15391 and Q06187 |
Pubmed |
SVM Score :0.0 |
| To study the effect of Btk activation in early B cell development in vivo , we have created transgenic mouse strains expressing Btk under the control of the human CD 19 promoter region . ^^^ |
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| Interacting proteins: P15391 and Q06187 |
Pubmed |
SVM Score :0.0 |
| To identify the cellular immune processes underlying intra ocular inflammation , aqueous humour was obtained at cataract surgery from 22 patients with clinically inactive uveitis and 24 patients with age related cataract . mRNA expression for the cytokines IL 1beta , IL 2 , IL 4 , IL 6 , IL 10 , IL 12 , interferon gamma ( IFN gamma ) , transforming growth factor beta ( TGF beta ) ; T cell subsets CD 3 , CD 4 , CD 8 ; monocytes and macrophages ( CD 14 ) ; and B cells ( CD 19 ) was measured using reverse transcriptase polymerase chain reaction ( RT PCR ) and radiometric analysis . ^^^ |
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| Interacting proteins: P15391 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Positive selection from newly formed to marginal zone B cells depends on the rate of clonal production , CD 19 , and btk . ^^^ |
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| Interacting proteins: P15391 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Loss of Lyn , PTEN ( phosphatase and tensin homolog ) , or SH 2 containing inositol phosphatase suppressed the Btk ( lo ) phenotype in vitro but not in vivo , whereas CD 19 and the p85alpha form of phosphoinositide 3 kinase behaved as Btk ( lo ) enhancers in vivo but not in vitro . ^^^ |
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| Interacting proteins: P15391 and Q06187 |
Pubmed |
SVM Score :0.0 |
| This study attempted to evaluate and compare the role of various B cell specific markers for anti viral immune responses in mouse strains lacking molecules belonging to the B cell receptor ( BCR ) complex ( IgM , Ig alpha and C ( kappa ) ) , the co stimulatory molecules ( CD 19 and CD 22 ) , the protein kinases [ Bruton ' s tyrosine kinase ( Btk ) ] or the transcription factors ( OBF 1 ) . ^^^ Absence of the co stimulatory molecules CD 19 and CD 22 or of the signaling molecule Btk had modulating effects , but did not increase susceptibility to VSV or LCMV . ^^^ |
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| Interacting proteins: P15391 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Several molecules such as Btk , Vav , and CD 19 known to be important for BCR signaling have been shown to be critical for the development of B 1 cells from undefined precursors . ^^^ |
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| Interacting proteins: P15391 and Q06187 |
Pubmed |
SVM Score :0.0 |
| We found that BCR mediated phosphorylation of CD 19 , Btk , Vav and phospholipase Cgamma 2 and association of CD 19 with phosphatidylinositol 3 kinase were impaired in CD 72 deficient cells . ^^^ |
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| Interacting proteins: P15391 and Q06187 |
Pubmed |
SVM Score :0.0 |
| In the Chinese , 2 beta globin defects at CD 41 / 42 and IVS 2 654 were responsible for 74 % of beta thalassemia . beta mutations at CD 19 , IVS 1 1 ( G T ) , IVS 1 5 , poly A , and hemoglobin E caused 76 % of the hemoglobin disorders in the Malays . ^^^ |
|
| Interacting proteins: P15391 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15391 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15391 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15391 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15391 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15391 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15391 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15391 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15391 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15391 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15391 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15391 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15391 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15391 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15391 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15391 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15391 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15391 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15391 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15391 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15391 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15391 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15391 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15391 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15391 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15391 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15391 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15391 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15391 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15391 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15391 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15391 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15391 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15391 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15391 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15391 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15391 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15391 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15391 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15391 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15391 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15391 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15391 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15391 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15391 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|