| Interacting proteins: P08631 and Q06187 |
Pubmed |
SVM Score :0.0 |
| In contrast , a quite different proline rich sequence from the Btk protein kinase binds to the Fyn , Lyn , and Hck SH 3 domains , but not to the Src SH 3 . ^^^ |
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| Interacting proteins: P08631 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Here , we show that Btk interacts with Src homology 3 domains of Fyn , Lyn , and Hck , protein tyrosine kinases that get activated upon stimulation of B and T cell receptors . ^^^ |
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| Interacting proteins: P08631 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Our data demonstrate that the tyrosine kinases p 56 ( Hck ) , p 72 ( Syk ) , p 77 ( Btk ) , p 62 ( Yes ) , p 56 ( Lck ) , and p 59 ( Fyn ) were specifically activated in response to spores from A . candidus , whereas spores from either A . niger or E . amstelodami activated p 56 ( Hck ) , p 72 ( Syk ) , and p 77 ( Btk ) . ^^^ Kinetic analysis of specific tyrosine kinases demonstrated that p 56 ( Hck ) , p 72 ( Syk ) , and p 77 ( Btk ) were activated faster and to a greater extent by spores from A . candidus as compared with spores from E . amstelodami . ^^^ Incubation with NADPH oxidase inhibitors inhibited both superoxide anion production and the activation of p 56 ( Hck ) , p 72 ( Syk ) , and p 77 ( Btk ) in response to fungal spores . ^^^ These data indicate that endogenous reactive oxygen species are necessary for the activation of p 56 ( Hck ) , p 72 ( Syk ) , and p 77 ( Btk ) by spores ; they also indicate that some species of spores are capable of activating tyrosine kinases independent of superoxide anion . . ^^^ |
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| Interacting proteins: P08631 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Importantly , we have identified Lyn and Syk as requisite tyrosine kinases and Hck , Btk , and protein kinase C theta as contributory kinases in HC IgE induced adhesion and spreading , whereas protein kinase C epsilon plays a negative role . ^^^ |
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| Interacting proteins: P08631 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Although mutation of a well conserved tryptophan ( W260A ) in the linker region of the Src family kinase Hck has been shown to cause a hyperactive kinase , an analogous mutation in Btk ( W395A ) dramatically decreased Btk kinase activity . ^^^ |
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| Interacting proteins: P08631 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08631 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08631 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08631 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|