| Interacting proteins: O00206 and Q06187 |
Pubmed |
SVM Score :0.59701685 |
| The ability of Btk to interact with TLR 4 and Mal suggests a role for Btk in lipopolysaccharide ( LPS ) signal transduction . 0.59701685^^^ Furthermore , co immunoprecipitation experiments revealed that Btk can also interact with key proteins involved in TLR 4 signal transduction , namely , MyD 88 , Mal ( MyD 88 adapter like protein ) , and interleukin 1 receptor associated kinase 1 , but not TRAF 6 . 0.55632394^^^ |
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| Interacting proteins: O00206 and Q06187 |
Pubmed |
SVM Score :1.0603619 |
| In fact Btk is activated by LPS and has been shown to directly bind TLR 4 and the key proximal signalling proteins involved in LPS induced NFkappaB activation , MyD 88 , Mal and IRAK 1 . 1.0603619^^^ |
|
| Interacting proteins: O00206 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Bruton ' s tyrosine kinase ( Btk ) has recently been shown to participate in the induction of nuclear factor kappaB ( NFkappaB ) dependent gene expression by the lipopolysaccharide ( LPS ) receptor Toll like receptor 4 ( TLR 4 ) . ^^^ |
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| Interacting proteins: O00206 and Q06187 |
Pubmed |
SVM Score :0.0 |
| This occurs after LPS increases TLR 4 and angiotensinogen mRNA , but proximal to AT ( 1 ) receptor activation . ^^^ |
|
| Interacting proteins: O00206 and Q06187 |
Pubmed |
SVM Score :0.0 |
| By comparison , surface TLR 4 staining with the Sa 15 21 mAb showed little downregulation , and the anti TLR 4 MTS510 mAb showed decreased staining , suggesting that LPS was bound to TLR 4 at the time points examined . ^^^ |
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| Interacting proteins: O00206 and Q06187 |
Pubmed |
SVM Score :0.0 |
| We demonstrate here that after TLR 2 and TLR 4 stimulation Mal becomes phosphorylated by Bruton ' s tyrosine kinase ( Btk ) and then interacts with SOCS 1 , which results in Mal polyubiquitination and subsequent degradation . ^^^ |
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| Interacting proteins: O00206 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Our study therefore provides the first demonstration of the key role of Mal phosphorylation on tyrosine during signaling by TLR 2 and TLR 4 and identifies a novel function for Btk as the kinase involved . . ^^^ |
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| Interacting proteins: O00206 and Q06187 |
Pubmed |
SVM Score :0.0 |
| These data provide evidence for a common requirement for Btk in TLR 2 and TLR 4 mediated induction of two important proinflammatory cytokines , TNF and IL 1beta , and reveal important differences in the TLR mediated signals required for the production of IL 6 , IL 8 , and IL 10 . . ^^^ |
|
| Interacting proteins: O00206 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Here we outline known discrepancies in both innate and adaptive immunity , including : balance of leukocyte subsets , defensins , Toll receptors , inducible NO synthase , the NK inhibitory receptor families Ly 49 and KIR , FcR , Ig subsets , the B cell ( BLNK , Btk , and lambda 5 ) and T cell ( ZAP 70 and common gamma chain ) signaling pathway components , Thy 1 , gammadelta T cells , cytokines and cytokine receptors , Th1 / Th2 differentiation , costimulatory molecule expression and function , Ag presenting function of endothelial cells , and chemokine and chemokine receptor expression . ^^^ |
|
| Interacting proteins: O00206 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00206 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00206 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00206 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00206 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00206 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00206 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00206 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00206 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00206 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00206 and Q06187 |
Pubmed |
SVM Score :0.0 |
| NA |
|