| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| The four proteins were identified as lithostathine 1 alpha precursor , pancreatitis associated protein 1 precursor , liver fatty acid binding protein and testis expressed protein 12 . ^^^ |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| We examined the expression of peptide 23 / PAP and a structurally related protein , pancreatic stone protein ( PSP / reg ) , in the rat gastrointestinal tract . ^^^ |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| A group of 16 kDa proteins , synthesized and secreted by rat pancreatic acinar cells and composed of pancreatic stone protein ( PSP / reg ) and isoforms of pancreatitis associated protein ( PAP ) , show structural homologies , including conserved amino acid sequences , cysteine residues , and highly sensitive N terminal trypsin cleavage sites , as well as conserved functional responses in conditions of pancreatic stress . ^^^ |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| Secretory stress proteins ( SSP ) are a family of proteins including isoforms of pancreatitis associated protein ( PAP ) and pancreatic stone protein ( PSP / reg ) . ^^^ |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| Sequence analysis suggests that the bovine pancreatic thread protein encoding gene is , in fact , the bovine homologue of the HIP gene . ^^^ Furthermore , data base searches revealed a significant similarity of the HIP and pancreatic stone protein / pancreatic thread protein / reg sequences with the C type lectin superfamily . ^^^ The HIP sequence , like pancreatic stone protein / pancreatic thread protein / reg protein , consists of a single carbohydrate recognition domain linked to a signal peptide which would be involved in secretion of the protein . ^^^ |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| The first model proposes that number of times in love ( Love ) leads to coitus ( Sex ) and that coitus increases premarital sexual permissiveness ( PSP ) , which in turn leads to greater acceptance of abortion ( PAP ) . ^^^ The paths between Love and PAP and between Love and PSP are negligible , indicating that the effects of Love on PSP and PAP are mediated by Sex . ^^^ The revised model suggests that as number of times in love increases so does coital experience and that coitus has both a direct effect on PAP and an indirect effect through PSP . . ^^^ |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| PSP values were compared with serum levels of prostate specific antigen ( PSA ) and prostatic acid phosphatase ( PAP ) . ^^^ In the BPH group , PSP was elevated ( > 10 ng / ml ) in 41 % of patients , whereas PSA ( > 4 ng / ml ) and PAP ( > 3 . 3 ng / ml ) were elevated in 39 % and 23 % of the cases , respectively . ^^^ PSP levels were elevated in 48 % of the CaP pretreatment specimens , compared to 79 % for PSA and 40 % for PAP . ^^^ PSP levels in cancer patients who had intracapsular disease were about two to three times higher than those observed for PAP . ^^^ PSP was found to be the only marker elevated in eight ( 6 % ) pretreatment CaP patient serum specimens , while PAP was never found to be elevated when PSA was normal . ^^^ |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| Reg 1 ( pancreatic stone protein , PSP ) and reg 3 ( pancreatitis associated protein , PAP ) are induced after the onset of acute pancreatitis , and both have been proposed as potential markers of pancreatitis . ^^^ |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| Pancreatic stone protein ( PSP / reg ) , which shows strong sequence homology to PAP , is secreted into pancreatic juice under physiologic and pathologic conditions . ^^^ |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| The majority ( 79 % ) would not hesitate to see a RN PSP for a Pap smear . ^^^ |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| Unfortunately in the cervical cancer example , the PSP design is also infeasible because it is not technically possible to administer both the ThinPrep and Pap at the same time . ^^^ |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| Using an in gel PTP assay we demonstrate that dephosphorylation catalyzed by potato acid phosphatase ( PAP ) reduces the activity of the 115 kDa PTP present in ZF from ACTH treated animals and PKA mediated phosphorylation reverses this effect . . ^^^ |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| We provide evidence for the localization of HIP / PAP on chromosome 2 , suggesting previous duplication of HIP / PAP and the related reg 1 alpha and reg 1 beta genes from the same ancestral gene . ^^^ |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| The rat genes encoding the pancreatitis associated proteins 1 , 2 and 3 ( Pap 1 , Pap 2 , Pap 3 ) , and the lithostathin / pancreatic stone protein / regeneration protein ( Reg ) colocalize at 4q33 > q 34 . ^^^ Using fluorescence in situ hybridization , we determined that the three rat PAP genes , and the related REG gene map in the same chromosomes region , namely 4q33 > q 34 . ^^^ This rat chromosome region is thus homologous to the human 2p12 region , which also contains the PAP gene , the REG1A gene , and a REG related gene ( REGL ) . . ^^^ |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| In addition to the 74 novel transcripts , 4 genes , prostate specific antigen ( PSA ) , prostate secretory protein ( PSP ) , prostate acid phosphatase ( PAP ) , and human glandular kallekrein 2 ( HK 2 ) , have no homologous sequences in the databases that originate from sources other than prostate and thus may represent genes with prostate restricted expression . ^^^ Sequences matching PSA , PSP , and PAP each accounted for > 1 % of the total ESTs and represent highly abundant transcripts , correlating with the abundance of these proteins in the prostate gland . ^^^ |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| We found significant overrepresentation of the haplotypes H 1 , extended up to the promoter of the tau gene ( H1P ) , in PSP patients as compared with controls . ^^^ |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| CONCLUSIONS : In this review we discuss the debate on the localization and functional roles of PSP / reg and PAP / regIII . ^^^ |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| The significant homology of the PAP / HIP gene to the Reg gene family prompted us to study in the same pituitary adenomas the presence of the related Reg genes . ^^^ We then extended our work to normal adults and developing human tissues to compare the expression patterns of the PAP / Reg gene family . ^^^ In conclusion , our results show that all of the human fetal and adult tissues examined express at least one of the different transcripts of the PAP / Reg family , suggesting that the regulation of these homologous genes is coordinately controlled . . ^^^ |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| In this review , factors regulating islet development including differentiation factors ( Shh , activin , follistatin , and TGF alpha ) , transcriptional factors ( PDX 1 , Isl 1 , Pax 4 , Pax 6 , Nkx2 . 2 , Nkx6 . 1 , BETA 2 , and HNF ) , growth factors ( the EGF family , HGF , IGF 1 , IGF 2 , Reg , INGAP , PDGF , FGF , VEGF , and NGF ) , hormones ( insulin , the GH family , PTHrP , TRH , and gastrin ) , and cell adhesion molecules ( N CAM and cadherins ) are described after a short introduction and an outline of pancreatic development . . ^^^ |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| Three genes encoding related proteins , PAP , reg Ialpha and reg Ibeta , were over expressed in cancer . ^^^ Western blotting with specific antibodies to pap and reg Ialpha revealed in tumors a single band of the expected size ( 15 16 kDa ) , demonstrating synthesis of the proteins . ^^^ No significant relationship was found between concentrations of pap , reg Ialpha or reg Ibeta and clinical outcome . ^^^ We looked at potential effectors of pap / reg gene over expression by testing , in 2 adenocarcinoma cell lines , the efficacy of the pap promoter at driving a reporter gene ; strong induction was observed upon exposure to IFNgamma and IL 6 . ^^^ By analogy with observations in hepatocellular carcinoma , our results suggest that prevention of PAP / reg expression in normal colon cells by silencing their gene promoters is relieved during colon carcinogenesis , allowing their up regulation by mediators such as cytokines . . ^^^ |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| Some of the type 3 Reg ( Reg 3 ) have recently been suggested to play roles in the regeneration of cells other than pancreatic beta cells , such as neuronal cells and epithelial cells in the alimentary tract . . ^^^ |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| Transcripts for the REG gene were found in 53 % of colorectal cancers and for the PAP gene in 60 % of colorectal cancers , by RT PCR . ^^^ However , in patients with non metastatic disease who underwent ostensibly curative surgery , the expression of REG alone and co expression of REG with PAP had a highly significantly adverse effect on survival . ^^^ |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| The ARIP and ARIP / PDX 1 cells were treated with known growth and differentiation factors including hepatocyte growth factor , activin A , betacellulin , reg , INGAP , nicotinamide , and retinoic acid . ^^^ |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| PAP 1 is a secreted protein related to the Reg family of trophic factors and was initially characterized as a protein elevated in pancreatitis . ^^^ |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| The pancreatitis associated protein ( PAP ) / regenerating protein ( REG ) family represents a complex group of small secretory proteins , which can function as acute phase reactants , lectins , antiapoptotic factors or growth factors for pancreatic beta cells and neural cells . ^^^ |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| In the setting of tissue injury associated with IBD , Reg Ialpha Reg Ibeta , and Reg 3 mRNA were highly expressed in colonic mucosa . ^^^ |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| The comparison of Reg 4 expression with that of other REG genes , Regenerating Ialpha or ( Reg Ialpha ) , Regenerating Ibeta ( Reg Ibeta ) and Pancreatitis associated protein ( PAP ) , highlights its predominant expression in colorectal tumors . ^^^ |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| Regenerating gene 3 ( Reg 3 ) was strongly induced in gut epithelial cells following bacterial reconstitution , as well as in the colitis initiated by DSS . ^^^ The mRNA expression of hepatocarcinoma intestine pancreas / pancreatic associated protein ( HIP / PAP ) , a human counterpart of Reg 3 , was enhanced in colonic epithelial cells of patients with IBD . ^^^ Reg 3 mRNA expression was localized in the epithelial cells including goblet cells and columnar cells in mice ; on the other hand , HIP / PAP expressing cells were correlated with Paneth cell metaplasia in human colon . ^^^ Epithelial expression of Reg 3 or HIP / PAP was induced under mucosal inflammation initiated by exposure to commensal bacteria or DSS as well as inflamed IBD colon . . ^^^ |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| In semi quantitative RT PCR , the expression of two genes , Reg ( Regenerating gene ) and INGAP ( islet neogenesis associated protein ) , in the diabetic APA hamsters was significantly increased compared to the control groups in both diabetic phases . ^^^ These data suggest that PB treatment in SZ injected diabetic hamsters partially restored beta cell function through acting as an antioxidant and induced higher expression of Reg and INGAP genes in the pancreas of hamsters . . ^^^ |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| All SZ groups treated with NAC , AG or PM had the high expression levels of Reg and INGAP , which are known to be expressed in regenerating islets . ^^^ |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| Molecular cloning , expression and chromosomal localization of a novel human REG family gene , REG 3 . ^^^ In the present study , we found a novel human type 3 REG gene , REG 3 . ^^^ REG 3 was expressed predominantly in pancreas and testis , but not in small intestine , whereas HIP / PAP was expressed strongly in pancreas and small intestine . ^^^ IL 6 responsive elements existed in the 5 ' upstream region of the human REG 3 gene indicating that the human REG 3 gene might be induced during acute pancreatitis . ^^^ All the human REG family genes identified so far ( REG Ialpha , REG Ibeta , HIP / PAP , REG 3 and REG 4 ) have a common gene structure with 6 exons and 5 introns , and encode homologous 158 175 aa secretory proteins . ^^^ |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| PURPOSE : Pancreatitis associated protein ( PAP ) and regenerating protein 1 alpha ( Reg1A ) are up regulated during the pancreas regeneration . ^^^ EXPERIMENTAL DESIGN : PAP and REG1A mRNA levels were measured in 265 surgically removed unifocal primary HCCs using reverse transcription PCR . ^^^ RESULTS : PAP and REG1A mRNAs were detected in 97 ( 36 . 6 % ) and 55 ( 20 . 8 % ) HCCs , respectively , including 46 with coexpression but in none of the 219 nontumorous livers . ^^^ HCCs with PAP expression correlated with low stage tumors without evidence of vascular invasion ( P = 0 . 013 ) but the REG1A expression did not . ^^^ By a combination analysis , HCCs with PAP expression alone showed the lowest frequency of p 53 mutation ( P < 0 . 036 ) , the highest rates of grade 1 and low stage tumors ( P < 0 . 007 and P < 0 . 001 , respectively ) , less frequent early tumor recurrence ( P = 0 . 051 ) , and hence a better 5 year survival ( P = 0 . 044 ) than groups expressing PAP and REG1A , REG1A alone , and neither PAP or REG1A . ^^^ |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| PAP IB , a new member of the Reg gene family : cloning , expression , structural properties , and evolution by gene duplication . ^^^ We therefore focused on two proteins , REG Ialpha and PAP IB , belonging to the more closely related FI and FII families , respectively . ^^^ REG Ialpha and PAP IB share 50 % sequence identity . ^^^ After cloning PAP IB , however , we found that it was expressed almost only in pancreas , unlike REG Ialpha , whose expression is ubiquitous . ^^^ In addition , by building a model of the structure of PAP IB based on the 10 ray structure of REG Ialpha , we observed that the two proteins displayed distinctive surface charge distribution , which may lead to different ligands binding . ^^^ |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| Of these identified proteins , Reg 3 which might be functionally associated with well known regenerating factor ( Reg 1 ) was found . ^^^ |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| Expression of Reg / PAP family members during motor nerve regeneration in rat . ^^^ In this study , we examined the expression of mRNAs for Regenerating gene ( Reg ) / pancreatitis associated protein ( PAP ) family members following hypoglossal nerve injury in rats . ^^^ In addition to four rat family members ( RegI , Reg 2 / PAP 1 , PAP 2 , and PAP 3 ) that had been identified , we newly cloned and sequenced a type 4 Reg gene in rats . ^^^ Among these five family members , the expression of Reg 2 / PAP 1 mRNA was predominantly enhanced in injured motor neurons after axotomy . ^^^ |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| They encode the Regenerating islet derived 3 alpha ( REG3A / HIP / PAP / REG 3 ) and 1 alpha ( REG1A ) proteins , both involved in liver and pancreatic regeneration and proliferation . ^^^ |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05451 and Q06141 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06141 and P05451 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06141 and P05451 |
Pubmed |
SVM Score :0.0 |
| The four proteins were identified as lithostathine 1 alpha precursor , pancreatitis associated protein 1 precursor , liver fatty acid binding protein and testis expressed protein 12 . ^^^ |
|
| Interacting proteins: Q06141 and P05451 |
Pubmed |
SVM Score :0.0 |
| In this review , factors regulating islet development including differentiation factors ( Shh , activin , follistatin , and TGF alpha ) , transcriptional factors ( PDX 1 , Isl 1 , Pax 4 , Pax 6 , Nkx2 . 2 , Nkx6 . 1 , BETA 2 , and HNF ) , growth factors ( the EGF family , HGF , IGF 1 , IGF 2 , Reg , INGAP , PDGF , FGF , VEGF , and NGF ) , hormones ( insulin , the GH family , PTHrP , TRH , and gastrin ) , and cell adhesion molecules ( N CAM and cadherins ) are described after a short introduction and an outline of pancreatic development . . ^^^ |
|
| Interacting proteins: Q06141 and P05451 |
Pubmed |
SVM Score :0.0 |
| The ARIP and ARIP / PDX 1 cells were treated with known growth and differentiation factors including hepatocyte growth factor , activin A , betacellulin , reg , INGAP , nicotinamide , and retinoic acid . ^^^ |
|
| Interacting proteins: Q06141 and P05451 |
Pubmed |
SVM Score :0.0 |
| In semi quantitative RT PCR , the expression of two genes , Reg ( Regenerating gene ) and INGAP ( islet neogenesis associated protein ) , in the diabetic APA hamsters was significantly increased compared to the control groups in both diabetic phases . ^^^ These data suggest that PB treatment in SZ injected diabetic hamsters partially restored beta cell function through acting as an antioxidant and induced higher expression of Reg and INGAP genes in the pancreas of hamsters . . ^^^ |
|
| Interacting proteins: Q06141 and P05451 |
Pubmed |
SVM Score :0.0 |
| All SZ groups treated with NAC , AG or PM had the high expression levels of Reg and INGAP , which are known to be expressed in regenerating islets . ^^^ |
|
| Interacting proteins: Q06141 and P05451 |
Pubmed |
SVM Score :0.0 |
| Sequence analysis suggests that the bovine pancreatic thread protein encoding gene is , in fact , the bovine homologue of the HIP gene . ^^^ Furthermore , data base searches revealed a significant similarity of the HIP and pancreatic stone protein / pancreatic thread protein / reg sequences with the C type lectin superfamily . ^^^ The HIP sequence , like pancreatic stone protein / pancreatic thread protein / reg protein , consists of a single carbohydrate recognition domain linked to a signal peptide which would be involved in secretion of the protein . ^^^ |
|
| Interacting proteins: Q06141 and P05451 |
Pubmed |
SVM Score :0.0 |
| We provide evidence for the localization of HIP / PAP on chromosome 2 , suggesting previous duplication of HIP / PAP and the related reg 1 alpha and reg 1 beta genes from the same ancestral gene . ^^^ |
|
| Interacting proteins: Q06141 and P05451 |
Pubmed |
SVM Score :0.0 |
| The significant homology of the PAP / HIP gene to the Reg gene family prompted us to study in the same pituitary adenomas the presence of the related Reg genes . ^^^ |
|
| Interacting proteins: Q06141 and P05451 |
Pubmed |
SVM Score :0.0 |
| We found significant overrepresentation of the haplotypes H 1 , extended up to the promoter of the tau gene ( H1P ) , in PSP patients as compared with controls . ^^^ |
|
| Interacting proteins: Q06141 and P05451 |
Pubmed |
SVM Score :0.0 |
| The first model proposes that number of times in love ( Love ) leads to coitus ( Sex ) and that coitus increases premarital sexual permissiveness ( PSP ) , which in turn leads to greater acceptance of abortion ( PAP ) . ^^^ The paths between Love and PAP and between Love and PSP are negligible , indicating that the effects of Love on PSP and PAP are mediated by Sex . ^^^ The revised model suggests that as number of times in love increases so does coital experience and that coitus has both a direct effect on PAP and an indirect effect through PSP . . ^^^ |
|
| Interacting proteins: Q06141 and P05451 |
Pubmed |
SVM Score :0.0 |
| PSP values were compared with serum levels of prostate specific antigen ( PSA ) and prostatic acid phosphatase ( PAP ) . ^^^ In the BPH group , PSP was elevated ( > 10 ng / ml ) in 41 % of patients , whereas PSA ( > 4 ng / ml ) and PAP ( > 3 . 3 ng / ml ) were elevated in 39 % and 23 % of the cases , respectively . ^^^ PSP levels were elevated in 48 % of the CaP pretreatment specimens , compared to 79 % for PSA and 40 % for PAP . ^^^ PSP levels in cancer patients who had intracapsular disease were about two to three times higher than those observed for PAP . ^^^ PSP was found to be the only marker elevated in eight ( 6 % ) pretreatment CaP patient serum specimens , while PAP was never found to be elevated when PSA was normal . ^^^ |
|
| Interacting proteins: Q06141 and P05451 |
Pubmed |
SVM Score :0.0 |
| We examined the expression of peptide 23 / PAP and a structurally related protein , pancreatic stone protein ( PSP / reg ) , in the rat gastrointestinal tract . ^^^ |
|
| Interacting proteins: Q06141 and P05451 |
Pubmed |
SVM Score :0.0 |
| The rat genes encoding the pancreatitis associated proteins 1 , 2 and 3 ( Pap 1 , Pap 2 , Pap 3 ) , and the lithostathin / pancreatic stone protein / regeneration protein ( Reg ) colocalize at 4q33 > q 34 . ^^^ Using fluorescence in situ hybridization , we determined that the three rat PAP genes , and the related REG gene map in the same chromosomes region , namely 4q33 > q 34 . ^^^ This rat chromosome region is thus homologous to the human 2p12 region , which also contains the PAP gene , the REG1A gene , and a REG related gene ( REGL ) . . ^^^ |
|
| Interacting proteins: Q06141 and P05451 |
Pubmed |
SVM Score :0.0 |
| In addition to the 74 novel transcripts , 4 genes , prostate specific antigen ( PSA ) , prostate secretory protein ( PSP ) , prostate acid phosphatase ( PAP ) , and human glandular kallekrein 2 ( HK 2 ) , have no homologous sequences in the databases that originate from sources other than prostate and thus may represent genes with prostate restricted expression . ^^^ Sequences matching PSA , PSP , and PAP each accounted for > 1 % of the total ESTs and represent highly abundant transcripts , correlating with the abundance of these proteins in the prostate gland . ^^^ |
|
| Interacting proteins: Q06141 and P05451 |
Pubmed |
SVM Score :0.0 |
| Three genes encoding related proteins , PAP , reg Ialpha and reg Ibeta , were over expressed in cancer . ^^^ Western blotting with specific antibodies to pap and reg Ialpha revealed in tumors a single band of the expected size ( 15 16 kDa ) , demonstrating synthesis of the proteins . ^^^ No significant relationship was found between concentrations of pap , reg Ialpha or reg Ibeta and clinical outcome . ^^^ We looked at potential effectors of pap / reg gene over expression by testing , in 2 adenocarcinoma cell lines , the efficacy of the pap promoter at driving a reporter gene ; strong induction was observed upon exposure to IFNgamma and IL 6 . ^^^ By analogy with observations in hepatocellular carcinoma , our results suggest that prevention of PAP / reg expression in normal colon cells by silencing their gene promoters is relieved during colon carcinogenesis , allowing their up regulation by mediators such as cytokines . . ^^^ |
|
| Interacting proteins: Q06141 and P05451 |
Pubmed |
SVM Score :0.0 |
| Transcripts for the REG gene were found in 53 % of colorectal cancers and for the PAP gene in 60 % of colorectal cancers , by RT PCR . ^^^ However , in patients with non metastatic disease who underwent ostensibly curative surgery , the expression of REG alone and co expression of REG with PAP had a highly significantly adverse effect on survival . ^^^ |
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| Interacting proteins: Q06141 and P05451 |
Pubmed |
SVM Score :0.0 |
| Reg 1 ( pancreatic stone protein , PSP ) and reg 3 ( pancreatitis associated protein , PAP ) are induced after the onset of acute pancreatitis , and both have been proposed as potential markers of pancreatitis . ^^^ Levels of reg I / PSP and reg III / PAP were estimated by enzyme linked immunosorbent assay . ^^^ Postinjury reg III / PAP levels significantly correlated with severity of the pancreatic injury and animal survival ; reg I / PSP levels did not . ^^^ Reg 1 ( pancreatic stone protein , PSP ) and reg 3 ( pancreatitis associated protein , PAP ) are induced after the onset of acute pancreatitis , and both have been proposed as potential markers of pancreatitis . ^^^ RESULTS : Reg III / PAP levels increased significantly the first day after induction of both types of pancreatitis and rapidly returned to baseline in all survivors . ^^^ |
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| Interacting proteins: Q06141 and P05451 |
Pubmed |
SVM Score :0.0 |
| Using an in gel PTP assay we demonstrate that dephosphorylation catalyzed by potato acid phosphatase ( PAP ) reduces the activity of the 115 kDa PTP present in ZF from ACTH treated animals and PKA mediated phosphorylation reverses this effect . . ^^^ |
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| Interacting proteins: Q06141 and P05451 |
Pubmed |
SVM Score :0.0 |
| Pancreatic stone protein ( PSP / reg ) , which shows strong sequence homology to PAP , is secreted into pancreatic juice under physiologic and pathologic conditions . ^^^ |
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| Interacting proteins: Q06141 and P05451 |
Pubmed |
SVM Score :0.0 |
| A group of 16 kDa proteins , synthesized and secreted by rat pancreatic acinar cells and composed of pancreatic stone protein ( PSP / reg ) and isoforms of pancreatitis associated protein ( PAP ) , show structural homologies , including conserved amino acid sequences , cysteine residues , and highly sensitive N terminal trypsin cleavage sites , as well as conserved functional responses in conditions of pancreatic stress . ^^^ Trypsin activation of recombinant stress proteins or counterparts contained in rat pancreatic juice ( PSP / reg , PAP 1 and PAP 3 ) resulted in conversion of 16 kDa soluble proteins into 14 kDa soluble isoforms ( pancreatic thread protein and pancreatitis associated thread protein , respectively ) that rapidly polymerize into insoluble sedimenting structures . ^^^ |
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| Interacting proteins: Q06141 and P05451 |
Pubmed |
SVM Score :0.0 |
| The pancreatitis associated protein ( PAP ) / regenerating protein ( REG ) family represents a complex group of small secretory proteins , which can function as acute phase reactants , lectins , antiapoptotic factors or growth factors for pancreatic beta cells and neural cells . ^^^ |
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| Interacting proteins: Q06141 and P05451 |
Pubmed |
SVM Score :0.0 |
| The comparison of Reg 4 expression with that of other REG genes , Regenerating Ialpha or ( Reg Ialpha ) , Regenerating Ibeta ( Reg Ibeta ) and Pancreatitis associated protein ( PAP ) , highlights its predominant expression in colorectal tumors . ^^^ |
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| Interacting proteins: Q06141 and P05451 |
Pubmed |
SVM Score :0.0 |
| Secretory stress proteins ( SSP ) are a family of proteins including isoforms of pancreatitis associated protein ( PAP ) and pancreatic stone protein ( PSP / reg ) . ^^^ |
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| Interacting proteins: Q06141 and P05451 |
Pubmed |
SVM Score :0.0 |
| PAP IB , a new member of the Reg gene family : cloning , expression , structural properties , and evolution by gene duplication . ^^^ We therefore focused on two proteins , REG Ialpha and PAP IB , belonging to the more closely related FI and FII families , respectively . ^^^ REG Ialpha and PAP IB share 50 % sequence identity . ^^^ After cloning PAP IB , however , we found that it was expressed almost only in pancreas , unlike REG Ialpha , whose expression is ubiquitous . ^^^ In addition , by building a model of the structure of PAP IB based on the 10 ray structure of REG Ialpha , we observed that the two proteins displayed distinctive surface charge distribution , which may lead to different ligands binding . ^^^ |
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| Interacting proteins: Q06141 and P05451 |
Pubmed |
SVM Score :0.0 |
| PURPOSE : Pancreatitis associated protein ( PAP ) and regenerating protein 1 alpha ( Reg1A ) are up regulated during the pancreas regeneration . ^^^ EXPERIMENTAL DESIGN : PAP and REG1A mRNA levels were measured in 265 surgically removed unifocal primary HCCs using reverse transcription PCR . ^^^ RESULTS : PAP and REG1A mRNAs were detected in 97 ( 36 . 6 % ) and 55 ( 20 . 8 % ) HCCs , respectively , including 46 with coexpression but in none of the 219 nontumorous livers . ^^^ HCCs with PAP expression correlated with low stage tumors without evidence of vascular invasion ( P = 0 . 013 ) but the REG1A expression did not . ^^^ By a combination analysis , HCCs with PAP expression alone showed the lowest frequency of p 53 mutation ( P < 0 . 036 ) , the highest rates of grade 1 and low stage tumors ( P < 0 . 007 and P < 0 . 001 , respectively ) , less frequent early tumor recurrence ( P = 0 . 051 ) , and hence a better 5 year survival ( P = 0 . 044 ) than groups expressing PAP and REG1A , REG1A alone , and neither PAP or REG1A . ^^^ |
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| Interacting proteins: Q06141 and P05451 |
Pubmed |
SVM Score :0.0 |
| Expression of Reg / PAP family members during motor nerve regeneration in rat . ^^^ In this study , we examined the expression of mRNAs for Regenerating gene ( Reg ) / pancreatitis associated protein ( PAP ) family members following hypoglossal nerve injury in rats . ^^^ In addition to four rat family members ( RegI , Reg 2 / PAP 1 , PAP 2 , and PAP 3 ) that had been identified , we newly cloned and sequenced a type 4 Reg gene in rats . ^^^ Among these five family members , the expression of Reg 2 / PAP 1 mRNA was predominantly enhanced in injured motor neurons after axotomy . ^^^ |
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| Interacting proteins: Q06141 and P05451 |
Pubmed |
SVM Score :0.0 |
| CONCLUSIONS : In this review we discuss the debate on the localization and functional roles of PSP / reg and PAP / regIII . ^^^ Similarly , PAP ( pancreatitis associated protein ) / reg 3 has been attributed various functional roles . ^^^ |
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| Interacting proteins: Q06141 and P05451 |
Pubmed |
SVM Score :0.0 |
| The majority ( 79 % ) would not hesitate to see a RN PSP for a Pap smear . ^^^ BACKGROUND : Registered nurse Papanicolaou ( Pap ) smear providers ( RN PSPs ) were introduced to improve women ' s accessibility to Pap smear services through the National Cervical Screening Program . ^^^ The majority of participants considered RN PSPs would be responsive to their needs ( 92 % ) and well qualified to perform Pap smears ( 70 % ) . ^^^ |
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| Interacting proteins: Q06141 and P05451 |
Pubmed |
SVM Score :0.0 |
| Some of the type 3 Reg ( Reg 3 ) have recently been suggested to play roles in the regeneration of cells other than pancreatic beta cells , such as neuronal cells and epithelial cells in the alimentary tract . . ^^^ |
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| Interacting proteins: Q06141 and P05451 |
Pubmed |
SVM Score :0.0 |
| In the setting of tissue injury associated with IBD , Reg Ialpha Reg Ibeta , and Reg 3 mRNA were highly expressed in colonic mucosa . ^^^ |
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| Interacting proteins: Q06141 and P05451 |
Pubmed |
SVM Score :0.0 |
| Regenerating gene 3 ( Reg 3 ) was strongly induced in gut epithelial cells following bacterial reconstitution , as well as in the colitis initiated by DSS . ^^^ The mRNA expression of hepatocarcinoma intestine pancreas / pancreatic associated protein ( HIP / PAP ) , a human counterpart of Reg 3 , was enhanced in colonic epithelial cells of patients with IBD . ^^^ Reg 3 mRNA expression was localized in the epithelial cells including goblet cells and columnar cells in mice ; on the other hand , HIP / PAP expressing cells were correlated with Paneth cell metaplasia in human colon . ^^^ Epithelial expression of Reg 3 or HIP / PAP was induced under mucosal inflammation initiated by exposure to commensal bacteria or DSS as well as inflamed IBD colon . . ^^^ |
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| Interacting proteins: Q06141 and P05451 |
Pubmed |
SVM Score :0.0 |
| Molecular cloning , expression and chromosomal localization of a novel human REG family gene , REG 3 . ^^^ In the present study , we found a novel human type 3 REG gene , REG 3 . ^^^ REG 3 was expressed predominantly in pancreas and testis , but not in small intestine , whereas HIP / PAP was expressed strongly in pancreas and small intestine . ^^^ IL 6 responsive elements existed in the 5 ' upstream region of the human REG 3 gene indicating that the human REG 3 gene might be induced during acute pancreatitis . ^^^ All the human REG family genes identified so far ( REG Ialpha , REG Ibeta , HIP / PAP , REG 3 and REG 4 ) have a common gene structure with 6 exons and 5 introns , and encode homologous 158 175 aa secretory proteins . ^^^ |
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| Interacting proteins: Q06141 and P05451 |
Pubmed |
SVM Score :0.0 |
| Of these identified proteins , Reg 3 which might be functionally associated with well known regenerating factor ( Reg 1 ) was found . ^^^ |
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| Interacting proteins: Q06141 and P05451 |
Pubmed |
SVM Score :0.0 |
| Unfortunately in the cervical cancer example , the PSP design is also infeasible because it is not technically possible to administer both the ThinPrep and Pap at the same time . ^^^ |
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| Interacting proteins: Q06141 and P05451 |
Pubmed |
SVM Score :0.0 |
| PAP 1 is a secreted protein related to the Reg family of trophic factors and was initially characterized as a protein elevated in pancreatitis . ^^^ |
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| Interacting proteins: Q06141 and P05451 |
Pubmed |
SVM Score :0.0 |
| They encode the Regenerating islet derived 3 alpha ( REG3A / HIP / PAP / REG 3 ) and 1 alpha ( REG1A ) proteins , both involved in liver and pancreatic regeneration and proliferation . ^^^ The upregulation of REG3A and REG1A expression is significantly correlated to the beta catenin status in 42 HCC and 28 hepatoblastomas characterized for their beta catenin status . ^^^ |
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| Interacting proteins: Q06141 and P05451 |
Pubmed |
SVM Score :0.0 |
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Pubmed |
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| Interacting proteins: Q06141 and P05451 |
Pubmed |
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| Interacting proteins: Q06141 and P05451 |
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| NA |
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| Interacting proteins: Q06141 and P05451 |
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| NA |
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| Interacting proteins: Q06141 and P05451 |
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| Interacting proteins: Q06141 and P05451 |
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| Interacting proteins: Q06141 and P05451 |
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| Interacting proteins: Q06141 and P05451 |
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| Interacting proteins: Q06141 and P05451 |
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| Interacting proteins: Q06141 and P05451 |
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| Interacting proteins: Q06141 and P05451 |
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| Interacting proteins: Q06141 and P05451 |
Pubmed |
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| Interacting proteins: Q06141 and P05451 |
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| Interacting proteins: Q06141 and P05451 |
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| Interacting proteins: Q06141 and P05451 |
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| Interacting proteins: Q06141 and P05451 |
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| Interacting proteins: Q06141 and P05451 |
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| Interacting proteins: Q06141 and P05451 |
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| NA |
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| Interacting proteins: Q06141 and P05451 |
Pubmed |
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| Interacting proteins: Q06141 and P05451 |
Pubmed |
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| Interacting proteins: Q06141 and P05451 |
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| Interacting proteins: Q06141 and P05451 |
Pubmed |
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| NA |
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| Interacting proteins: Q06141 and P05451 |
Pubmed |
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| NA |
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| Interacting proteins: Q06141 and P05451 |
Pubmed |
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| NA |
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| Interacting proteins: Q06141 and P05451 |
Pubmed |
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| NA |
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| Interacting proteins: Q06141 and P05451 |
Pubmed |
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| NA |
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| Interacting proteins: Q06141 and P05451 |
Pubmed |
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| NA |
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| Interacting proteins: Q06141 and P05451 |
Pubmed |
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| NA |
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| Interacting proteins: Q06141 and P05451 |
Pubmed |
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| NA |
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| Interacting proteins: Q06141 and P05451 |
Pubmed |
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| NA |
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| Interacting proteins: Q06141 and P05451 |
Pubmed |
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| NA |
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| Interacting proteins: Q06141 and P05451 |
Pubmed |
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| Interacting proteins: Q06141 and P05451 |
Pubmed |
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| Interacting proteins: Q06141 and P05451 |
Pubmed |
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| Interacting proteins: Q06141 and P05451 |
Pubmed |
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| Interacting proteins: Q06141 and P05451 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q06141 and P05451 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q06141 and P05451 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q06141 and P05451 |
Pubmed |
SVM Score :0.0 |
| NA |
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